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Al Amyloidosis
Wikipedia
External links [ edit ] Classification D ICD - 10 : E85 ICD - 9-CM : 277.3 OMIM : 254500 MeSH : C531616 DiseasesDB : 315 External resources MedlinePlus : 000533 eMedicine : med/3363 v t e Amyloidosis Common amyloid forming proteins AA ATTR Aβ2M AL Aβ / APP AIAPP ACal APro AANF ACys ABri Systemic amyloidosis AL amyloidosis AA amyloidosis Aβ2M/Haemodialysis-associated AGel/Finnish type AA/Familial Mediterranean fever ATTR/Transthyretin-related hereditary Organ-limited amyloidosis Heart AANF/Isolated atrial Brain Familial amyloid neuropathy ACys+ABri/Cerebral amyloid angiopathy Aβ/Alzheimer's disease Kidney AApoA1+AFib+ALys/Familial renal Skin Primary cutaneous amyloidosis Amyloid purpura Endocrine Thyroid ACal/Medullary thyroid cancer Pituitary APro/Prolactinoma Pancreas AIAPP/Insulinoma AIAPP/Diabetes mellitus type 2 v t e Immunoproliferative immunoglobulin disorders PCDs / PP Plasmacytoma Multiple myeloma ( Plasma cell leukemia ) MGUS IgM ( Macroglobulinemia / Waldenström's macroglobulinemia ) heavy chain ( Heavy chain disease ) light chain ( Primary amyloidosis ) Other hypergammaglobulinemia CryoglobulinemiaCCND1, LINC02343, CBX7, LINC00457, SMARCD3, TTR, DNAH11, CD38, SCT, GDF15, NPPB, SPP1, IGKV2-29, MIR34A, SMN1, SMN2, ST2, TNF, BMS1P20, KRT20, IGKV1-8, BABAM2, GLIPR1, WDHD1, MAGEC2, SLC1A4, PLXNB2, IGKV3D-15, IGKV1D-8, IGKV3-20, PRAME, ALB, SDC1, FGA, BCR, PRDM1, CAT, MS4A1, CDA, CDH1, CRP, CSF3, CYP1B1, DDT, ETFA, GSN, FAS, IGKV@, LGALS3, LGALS4, MDK, MMP1, MMP2, MUC1, MYD88, NCAM1, PFDN5, RPS27A, SAA1
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Cognitive Deficit
Wikipedia
"Cognitive impairment" redirects here. For other forms of cognitive impairment, see Dementia . Cognitive deficit Other names Cognitive impairment Specialty Psychiatry Cognitive deficit is an inclusive term to describe any characteristic that acts as a barrier to the cognition process . [1] The term may describe deficits in overall intelligence (as with intellectual disabilities ), specific and restricted deficits in cognitive abilities (such as in learning disorders like dyslexia ), neuropsychological deficits (such as in attention , working memory or executive function ), or it may describe drug-induced impairment in cognition and memory (such as that seen with alcohol , glucocorticoids , [2] and the benzodiazepines . [3] ) Contents 1 Cause 2 Screening 3 Treatment 4 Other findings 5 See also 6 References 7 Further reading 8 External links Cause [ edit ] It usually refers to a durable characteristic, as opposed to altered level of consciousness , which may be acute and reversible. Cognitive deficits may be inborn or caused by environmental factors such as brain injuries , neurological disorders , or mental illness . [4] [5] Screening [ edit ] Screening for cognitive impairment in those over the age of 65 without symptoms is of unclear benefit versus harm as of 2020. [6] Treatment [ edit ] Older people with cognitive impairment appear to improve somewhat with light therapy . [7] Other findings [ edit ] Although one would expect cognitive decline to have major effects on job performance , it seems that there is little to no correlation of health with job performance. With the exception of cognitive-dependent jobs such as air-traffic controller, professional athlete, or other elite jobs, age does not seem to impact one’s job performance. This obviously conflicts with cognitive tests given, so the matter has been researched further.PSEN1, MAPT, APP, APOE, COMT, FMR1, GSK3B, BCHE, PTGS2, DRD2, EPO, CDK5R1, VIP, FGF14, MAOA, EIF2S1, SLC1A1, SLC10A2, MET, DRD3, SMAD4, LAMB2, TSC1, AGT, ZNF41, RAB40AL, SLC51A, NR0B2, IGF2, OTC, SLC51B, CRH, ABCC4, FOSB, OXTR, SLC4A10, AFF4, SLC6A4, CYP2D6, ACHE, DYRK1A, BDNF, PVALB, DISC1, NFE2L2, CHRNA4, BACE1, PIK3CB, PIK3CA, PIK3CD, PIK3CG, SIRT1, GABPA, SNCA, TNF, MTOR, HTT, RELN, DTNBP1, CFP, CDK9, KL, AKT1, NUFIP2, VEGFA, GBA, GRN, GRM5, ACTB, CNR1, CSF2, DLG4, MME, IL6, SYP, LAMC2, DMD, IL4, IL1B, NGF, PREP, PERCC1, MIR34A, PDE4A, PDE2A, EPHB2, FOXP1, MAPK1, TARDBP, SNAP25, ADIPOQ, FUS, HTR2A, NRG1, TCF4, TGFB1, HDAC6, GRM2, GRM3, SUCLA2, ABCA1, CREB1, CDK5, CASP6, CACNA1C, ADAM10, CRP, H3P40, NUBP1, NFKB1, RUNX1T1, NGFR, DCTN4, ASCC1, NOTCH3, MECP2, NTS, UBQLN2, AGTR1, POLDIP2, CD36, CD40, CASP1, AKR1C4, HMGB1, LRRK2, CHRNA7, NLRP3, IGF1, CHRNA5, COASY, SHROOM4, IL10, EHMT1, INSR, CIP2A, CDR1, LEP, RNF19A, PLA2G1B, NUP62, HDAC2, SPP1, SPTBN1, GRAP2, LGI1, TM7SF2, SQSTM1, ARHGEF7, SYNJ1, APLN, UBE3A, BECN1, VCAM1, TP63, VSNL1, YWHAZ, GTF2IRD1, SLC6A8, ANGPT1, PTPN11, PTPA, CALB1, MAPK8, SYNM, PTEN, HRH3, REST, SLC1A2, S100B, NRG3, SCN1A, KHDRBS1, AHSA1, SIGMAR1, TAAR1, TREM2, AIMP2, GAD1, GTF2H1, DAB1, GRIA1, CRK, GH1, MIR132, GFAP, FGFR3, ADCYAP1, CREBBP, CUX1, DBH, CX3CR1, CYBB, ERBB4, DBN1, NR3C1, PLB1, MAPK14, CHL1, MIR361, NPS, SNORD116@, CXCR6, SPAG11A, SFTPA1, PDE10A, TXNRD2, BAIAP2, SPAG11B, TUBA1B, RTN3, MIR574, GJB6, ADAMTS13, PPARGC1A, MIR342, ALDH2, SIRT3, ADNP, MED13L, CRTC1, MIR21, AGTPBP1, ASTN2, MDD1, ARC, PHF8, NMNAT2, VN1R17P, GPR166P, FAM107A, PSIP1, IL1RAPL1, OLIG2, SDS, EHMT2, GADD45G, AMPH, SETD1A, OPN1MW2, PSME3, OCLN, FPGT-TNNI3K, OPN1MW3, CBSL, ANXA1, HDAC3, SYNGAP1, ADA, APOA1, UPK3B, MTCO2P12, PDE5A, NCOA1, H3P45, PSMG1, KHSRP, NCK2, APOB, FZD4, ANP32A, AP3B2, EIF2S2, NOL3, CDKL2, NTN1, KEAP1, NCS1, HDAC9, ABCG1, CCR2, PTGES, HOMER2, AD10, GS1-600G8.3, C20orf181, SEMA5A, NRXN1, ANK3, ANPEP, TGM5, SRSF11, NOG, ECT, LPAR2, USP2, MIR188, OR2AG1, MIR181C, ALB, CALHM1, SPG11, PCSK9, TNFAIP8L2, PLEKHF1, LYNX1, DCLRE1C, LGR6, ACE2, NGB, PCDH10, SEMA6A, MRGPRX1, ADRA2B, PCDH19, KIDINS220, COPD, ADRB1, PCBP4, ACKR3, NPAS4, GPRC6A, DIPK2A, SRCIN1, ADCYAP1R1, GPR151, VPS13B, HSPB6, ADRA1A, DEGS2, OXER1, MRGPRX4, MRGPRX3, OMA1, KLHDC8B, TRAPPC9, CDCA5, FOXP2, CHRDL1, SLC39A13, CHRFAM7A, PTPN5, C9orf72, ADRA2A, KLF16, PAG1, NSUN5, CCDC141, AUTS2, IRF2BP2, RTL1, IGHD4-11, TMEM97, SRPX2, AGER, AHR, SIGLEC7, HES5, NECTIN3, DNAAF3, MIR137, TPSG1, SLC24A2, BRD1, FRRS1L, PDIK1L, AIF1, LPAR3, MAPK8IP2, HDGFL3, TNNI3K, CHD7, FAM3B, SMPD3, CCDC91, RCBTB1, CC2D1A, PGPEP1, AHI1, TMEM106B, EPM2A, NANS, SETD4, GEN1, GOLGA6A, CINP, HOOK1, ZDHHC3, MCIDAS, NRN1, CD320, CRBN, TUBB2B, MIR181A2, DCX, LRP8, IFIT1, IL18, IL13, IL12A, CHAT, IL2RB, CHI3L1, IKBKB, IGFALS, IFNG, IFNA13, IFNA1, IAPP, IRS1, HTR4, HTR2C, HTR1A, HSPA4, PRMT2, AGFG1, HPRT1, HOXA1, HMOX1, HIF1A, CLCN3, IDO1, ITGAM, CLU, MDM2, RNR2, COX2, COX1, MS, MPO, CD200, MNAT1, MMP9, MMP2, CBS, MAP3K5, MAOB, ITPR1, CDH1, CAPRIN1, LIMK1, LGALS9, LGALS3, LCN2, CEACAM4, KCNQ2, KCNJ6, JAK2, ITPR3, HDAC1, HCRT, FAS, CYP1A2, FGFR1, CXADR, FES, FDPS, FCN2, FAT1, PTK2B, FABP5, FABP3, ETS2, ESR1, EPHA4, FOXO3, ENO2, EIF4E, EIF2S3, EGR1, EDNRA, EDN1, TOR1A, DAO, DUSP2, DUSP1, DRD4, FOXO1, AFF2, HCLS1, GLUL, HCFC1, HARS1, GZMH, GTF2I, KLF6, GRPR, GRP, CORT, GRIN2B, GRIA2, GPR42, GLI3, FOLR1, GJB2, GIP, MSTN, GDF2, OPN1MW, GCHFR, GCG, FYN, FUT1, CST3, CTRL, MTRR, CEACAM6, NEUROD1, BRCA1, BMI1, STAT3, SSTR4, SST, SREBF1, SOX4, SOD1, SOAT1, BMP1, BMP2, SMARCA4, BRAF, ATP5F1A, SLC2A3, BRS3, SFRP1, SETMAR, SET, SELP, CX3CL1, CCL11, CCL2, SCN8A, SCN2A, TAT, TCF3, NF1, UBC, XPNPEP1, CLIP2, WAS, TRPV1, VLDLR, AQP4, AR, VDR, VCP, UFD1, SUMO1, TXN, TCN2, ARSD, TPT1, TPM2, TNFRSF1B, ASL, TLR4, TLR2, TJP1, THY1, DRD1, TDO2, ATXN1, TSPAN31, S100A1, PAFAH1B1, CALB2, CAMK4, CAPN1, CAST, PEPD, PDE9A, PDE4D, CASP2, CASP3, PAK3, SERPINE1, CAT, RXRA, ORM1, OPRL1, OPHN1, NTRK1, NRGN, NOVA2, NOTCH1, NOS2, NOS1, NMB, CBR1, PITX2, PLAT, PLD2, PNOC, RPS27A, RPS6KB1, OPN1LW, RBM3, RARB, MOK, RAC1, BUB1B, PTPRG, ACAT1, PTGS1, PTGER3, PTGER2, PSMC1, PSEN2, C5AR1, PRNP, MAPK10, MAPK3, CAD, PRKCA, PRCP, PPARA, ATP1A3
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Down Syndrome
Omim
The triplication of the amyloid precursor protein gene (APP; 104760) may be the cause of this phenomenon. Several mutations in the APP gene have been described in families with early-onset Alzheimer disease without trisomy 21 (e.g., Goate et al., 1991). ... Busciglio et al. (2002) found that astrocyte and neuronal cell cultures derived from Down syndrome fetal brains had increased intracellular levels of insoluble beta-amyloid-42 and decreased levels of secreted beta-amyloid. These abnormal patterns of APP (104760) processing were recapitulated in normal astrocytes by inhibition of mitochondrial metabolism. ... In Ts65Dn and Ts1Cje mouse models of Down syndrome, Salehi et al. (2006) found that increased dosage of the App gene markedly decreased retrograde transport of nerve growth factor (NGF; 162030), thus resulting in degeneration of cholinergic neurons in the basal forebrain. NGF-containing early endosomes were enlarged in cholinergic axons of the Ts65Dn mice and their App content was increased. The findings demonstrated a pathogenic mechanism for Down syndrome whereby disrupted axonal transport in certain neurons results in neuronal degeneration.S100B, SLC19A1, MTHFR, GATA1, RCAN1, SOD1, MIR155, DCR, MIR802, PRDX2, MIR125B2, MIR99A, VIP, PRDX6, CXCL8, CALCA, MIRLET7C, NTF3, GSTM2, DYRK1A, RPLP0, CBS, ETS2, ERG, JAK2, DSCAM, MAPT, CRLF2, MTR, MTRR, RUNX1, TP53, PAPPA, ACTB, APP, CBSL, APOE, AFP, SIM2, RFC1, PSEN1, COL6A1, TTC3, HTC2, CGB3, TNF, S100A1, CGA, POTEF, BACE1, BDNF, SOAT1, KCNJ6, CCL4L1, CCL4, CCL4L2, PLAC4, CGB5, CGB8, COL6A2, IL1B, IL6, CRELD1, DNMT3B, MECP2, SOD2, OLIG2, BACE2, ETV6, PGF, CASP3, RET, HLCS, GET1, EDNRB, PCNT, HMGN1, NEFL, IFNA1, SERPINA1, IFNG, IL1A, DOP1B, SYNJ1, IFNA13, MCIDAS, CAT, AIRE, ABL1, XPNPEP1, SH3BGR, CD6, SQSTM1, CHDH, ITSN1, ENO2, PRNP, SLC25A1, ADAM12, BHMT, IL10, CD19, POLB, CD34, MIR1246, DICER1, ITGB2, EZH2, FABP7, PTCH1, VEGFA, PIGP, GFAP, DNMT3L, CBR1, GART, GAPDH, RAB5A, ALB, HLA-A, PABPC4, TNFRSF10C, CHAF1B, AKT1, SUCLA2, CCL2, SET, FANCB, JAK3, REST, PCP4, BACH1, BCL2, CSF2, MTHFD1, BCHE, LEP, NOS3, CDKN2A, COL18A1, UBB, LAMC2, SNX27, HT, KIT, NFATC1, NGF, USP25, OXA1L, RENBP, NFIC, ABCG1, USP16, PRDX1, NFIB, CCND1, PTGS2, HMOX1, HMGB1, MX1, CALB2, NOP53, NCAM2, NFIA, MMP9, TRIB1, IKZF1, DSCR4, MPL, PIK3CD, KMT2A, APOA1, OPN1SW, BCR, ABCB1, ITGAM, ITGA2B, TARDBP, PKNOX1, INHA, ADIPOQ, RASSF1, PML, PFKL, IL10RB, IL2RA, IL2, IL1RN, IMMT, IGFBP7, STIP1, PRDX3, IFNAR2, RELN, TP73, IFIT3, CFAP410, NAE1, BCAR1, GRIK1, NFIX, GJB2, DHFR, U2AF1, CTNNB1, CTNND1, SYP, DBN1, DCK, DLX4, XRCC1, CD63, DPYSL2, SORL1, CD59, TMX2-CTNND1, MYL7, CSTB, TCN2, CSF3, CSE1L, TYMS, H3P7, TWIST1, ERVH48-1, TTN, P2RY8, COMT, TSHR, TGFB1, TGM2, ESCO1, TNFRSF1A, TPO, SLC12A5, CDA, FLT3, RHD, FAM3B, GATA4, FN1, TREM2, MTOR, PICALM, ARHGEF5, TRRAP, MATR3, USP9X, TXN, VAMP8, PSG10P, POU5F1P4, TNFSF10, TP63, TYRP1, GATD3A, APOBEC3B, MIR590, CCR2, GDF15, TTR, MIR3197, AKR7A2, RCAN2, LOH19CR1, DENR, H3P9, TPTE, HSP90B1, TRH, TRPM2, TSC2, MIR486-1, FXR2, ACTR2, PDXK, DNM1L, POU5F1P3, MAGI2, TMEM72, ZEB2, SCRN1, PHYHIP, ADAMTS1, YWHAG, DSCAM-AS1, GATD3B, EIF2B4, ZMYM2, IL1RL1, EIF2B2, RNF103-CHMP3, AVSD1, LPAR2, UBA3, FAS-AS1, MAP3K14, WT1, XIST, ZFY, HAP1, BCL10, EIF2S2, MTRNR2L12, COX5A, RECQL4, ZNF587B, NTN1, EIF2AK3, MIR3196, NRIP1, ABCG2, UBE3A, USP5, SOD2-OT1, UTRN, UVRAG, USP7, LINC02605, VIPR1, BEST1, MIR1973, MCM3AP, PAX8, VPREB1, TET3, SDS, DCAF7, ACKR3, ENOSF1, KIF21A, SEPTIN11, PARD3, NPDC1, SLC12A9, PLSCR4, STRBP, ACTR3B, AICDA, LRRC47, NUFIP2, MRTFA, RNF213, MIA3, RTL1, DCTN4, RBM11, NT5C3A, PRRX2, TDP2, CHMP3, RIPPLY3, BRWD1, SETD4, PACC1, RIPK4, C21orf91, RBFOX1, TET2, PGPEP1, STX17, LSM2, PRM3, HPSE2, TAF8, AP5B1, UBXN11, SLC13A5, MYL12B, PRRT2, DSCR9, AHSA2P, PRDM16, VENTXP1, LYPD4, STRC, TMPRSS6, ARX, HEPACAM, BAGE2, TMEM241, GLIS2, COL25A1, FGFBP2, ARHGAP24, MED25, LPAL2, TET1, DERL1, TAS2R62P, NANOS3, WNK1, GORASP1, CPEB1, NOD2, SAMSN1, HSPA14, COPS4, EFS, CKAP4, NES, ARPP19, PPARGC1A, PSG8, SUB1, PRSS21, DHFR2, CXCR6, STMN2, MMRN1, MCF2L, ICOSLG, SYNM, ANGPTL2, CHL1, KHDRBS1, APH1A, SLC9A6, TUBB3, RACK1, PEMT, OLFM1, MCRS1, MAD2L2, PLF, MYL12A, CIB1, DPYSL4, MRPL28, GNLY, AHSA1, SPAG5, HEY2, TMEM131, MORC3, REM1, CRCP, APEX2, HPGDS, MIR145, SGSM3, IGHV1-12, NXT1, FAM215A, LGALS13, CNOT7, GMPPA, ZBTB21, IL22, GMNN, GPR162, B3GAT1, CKAP2, PLA2G2D, APPL1, MIR146A, CHD5, MIR17, MTHFD1L, MIR183, MIR191, POC1A, MIR199B, MIR30C1, NUP62, MIR30C2, DAPK2, A1BG, PTH, TNNT2, EDNRA, EEF1A2, EGFR, EGR2, EGR3, EIF2B1, ELANE, ELK1, ENG, ENSA, EPAS1, ERBB2, ERCC2, ERCC3, ERF, ESR1, EEF1A1, E2F1, HP, DSG1, NKX2-5, CYP2B6, CYP17A1, CYP19A1, DBH, DBP, DGCR, DMD, DNAH8, DNASE1, DNMT1, DNMT3A, DPYSL3, DRD4, ATN1, ESR2, FABP3, FABP5, FBN2, GPT, GPX1, GPX3, GSN, GTF2H1, GYPA, GYPB, GYPE, HSD17B10, HAS2, CFH, HINT1, HLA-B, HLA-DQA1, HNMT, GPR42, GPI, GJA1, FLT1, FCGR3A, FCGR3B, FEB1, FGFR1, FGFR3, FLNA, FMR1, GHR, FYN, GABPA, GAD1, GAP43, GDI2, GH1, CST3, CRP, CRMP1, BTG1, ARNT, ARSA, STS, ARSD, ASPA, SERPINC1, AZGP1, BAX, BCL2L1, BCL6, BDKRB1, BGN, BLVRA, BMI1, BRS3, AQP4, APOC2, APOA2, ADRA1A, SERPINA3, ACO1, ACVR1, ADAR, PARP1, PARP4, ADRA2B, APEX1, ADRB2, AGA, AGTR1, AHSG, AMPH, ANK1, BST2, C9, CREB1, CA2, CHRNA7, CHRNB2, CLU, CCR5, CNR1, COL4A3, COL6A3, COL7A1, COX8A, CP, CPE, CPOX, CPS1, CPT1B, CR2, CHRNA4, CHRNA3, CHAT, CDK1, CAMP, CASP1, RUNX1T1, CD247, CD14, CD38, CDK6, CENPB, CDKN1A, CDKN1B, CDKN1C, CDKN2B, CEBPE, CECR, HNRNPA2B1, PRMT2, TLR4, PSMA5, PTPN4, PTPN11, PTPRF, PWP2, RAB4A, RARA, RBM4, RBP4, RCN1, RELA, BRD2, RPE65, RPL17, RPS19, RYR2, A2M, PSG5, HSPA4, PSEN2, PDYN, PGD, PIP4K2A, PLG, PLEK, PLTP, PRRX1, POLD1, PON1, POU5F1, PPP2CA, MAPK10, PRL, TMPRSS15, PSD, SETMAR, SFPQ, SRSF6, SH3BGRL, CDKL5, SYT1, TBX1, TCP1, TRBV20OR9-2, TEAD4, TERC, TFAM, TFCP2, TFF1, TG, THBS1, TIAM1, TIMP3, TLR2, HSPA13, STATH, STAT3, SLC6A4, SHBG, SHMT1, SHMT2, SHOX, SIM1, SLC5A3, SNAP25, STAT1, SNCA, FSCN1, SNRNP70, SOX11, SRY, SSTR4, PDGFB, PDE9A, PDE4C, MDM4, KCNE1, KCNJ15, KISS1, KNG1, KRT8, STMN1, LBP, LBR, LHCGR, LRP2, LTA4H, MAOA, MARK1, MBP, CD46, KCNA3, ITGAL, ISL1, IL7, HSPD1, ICAM1, IDE, IFNAR1, IGH, IL4, IL15, ISG20, IL16, IL17A, IDO1, INPP5D, INSL4, IRF1, MDM2, MME, PDE4B, MOS, NFKB1, NHS, NME1, NME2, NOS2, NPM1, NT5E, NTRK1, NR4A2, OCA2, PAH, PAK1, PAK3, PAX5, PCYT1A, NFE2L2, NFATC2, NEFH, RNR2, MPO, MRC1, MT2A, ATP6, ND3, MTNR1B, MYD88, NDUFV3, MYO9B, NACA, NAIP, NCAM1, NDUFA2, NDUFS3, H3P10
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Stroke, Ischemic
Omim
The genes that have been identified include APP (104760), BRI (603904), and CST3 (604312), causing autosomal dominant amyloid angiopathies; NOTCH3 (600276), causing cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL; 125310); and KRIT1 (604214), causing cavernous angioma (116860).GLA, APP, COL3A1, ITM2B, F2, NOTCH3, F5, ADAMTS13, HDAC9, CDKN2B-AS1, LDLR, ALDH2, ABO, ZFHX3, ACTA2, PDE3A, PROCR, ABCC1, TGFBR2, LOX, PRKG1, SMAD3, COL4A1, SLCO1B1, PIK3CD, COX7A2L, MYLK, SLC2A10, TGFB3, PIK3CG, PON1, NTN4, PLAT, PLG, TGFB2, MYH11, PIK3CA, PPARG, CYP2C19, MTHFR, PIK3CB, PDE4D, TGFBR1, PLAA, FGB, NOS3, TNF, FBN1, FUNDC2, CHD3, CRP, TLR4, CDKN2C, KCNK1, MIR146A, CDKN1A, CDK6, NINJ2, PCSK9, SERPINE1, CDC5L, PCDH7, VEGFA, PCYT1A, TSPAN15, BDNF, FOXE3, ILF3, RUNX1, VWF, PTGS2, PMF1, PROC, AGBL1, MMP9, ATXN2, ADIPOQ, ENG, KIF26B, ELN, AGTR1, AGT, LPA, CASZ1, PATJ, EDN1, LPL, MFAP5, F11-AS1, SON, SLC26A11, ACVRL1, MAT2A, CERNA3, LRCH1, DINOL, SMARCA4, NAALADL2, ALOX5, ALOX5AP, ACE, IL1B, SLC44A2, AVP, QRICH2, HPS4, ALDH1A2, PTPRD, PTPRG, IL10, FAF1, C20orf181, NLRP3, IL6, KCNK3, APOE, C10orf143, APOA5, APOB, DAB1, SH2B3, IL1RN, STAT3, PRPF8, TSPAN33, PMF1-BGLAP, MMP3, EPO, CYP4F2, HMGB1, PLA2G7, SELP, MIR499A, CXCL8, NFE2L2, IGF1, AQP4, IL17A, LTA, P2RY12, MIR126, CCL2, CXCL12, EPHX2, FGFR1, MIR145, SELE, ESR1, IL1A, GABPA, MMRN1, OLR1, HIF1A, CDKN2A, TNFRSF11B, ICAM1, TREM2, AGER, PPIG, CETP, MIR223, CASP3, CYP11B2, SIRT1, PTGS1, IL18, TGFB1, JAK2, ITGA2, IL4, GPX3, LGALS3, MTOR, APLN, KALRN, NGF, GP6, SIGMAR1, THBD, BRCA1, PRKCH, TP53, RETN, ABCB1, CPB2, KL, MMP2, MMP1, ABCA1, MAPK3, CD40, IL33, CAV1, GDF15, PON2, ITGA2B, PPARA, MIR122, MAPK1, UCP2, SERPINC1, REN, HDAC6, MALAT1, APOC3, SIRT3, CHDH, ANGPT1, ALOX15, IFNB1, PARP1, HSPA4, SPP1, MTCO2P12, NRG1, ITGB3, CBS, HMOX1, CSF3, MPO, COX2, LEP, TRAF6, LCN2, CYP4A11, F3, ENO2, NEFL, VKORC1, CST3, MIR149, MMP12, KNG1, COX8A, FABP4, CDKN2B, COL4A2, NOS2, NPY, KLK1, MIR143, CCL11, SELPLG, TNFRSF12A, MMP10, MIF, LGALS2, SLC1A2, LIF, SLC25A1, HLA-DRB1, HFE, RNLS, MMP8, SERPINA3, P2RY1, ACSM3, PTX3, MAP3K5, SNHG12, NOS1, IL13, XBP1, XRCC1, ANGPTL4, COX1, IL6R, SELENOS, KCNK17, MEG3, S100B, LGALS1, POLDIP2, LTC4S, BSG, ADAMTS7, TP63, SOCS1, DNM1L, APOA1, F13A1, EDNRB, MIR19A, CD40LG, ROCK2, CCR2, PTGES, MIR210, BCL2, MIR130A, MIR155, CAD, F2R, ARHGEF10, F11, MIR137, FGA, CELSR1, MIR21, CDK5, DPP4, NTN1, GRIN2A, GSK3B, CYP2C9, MIR30A, SIRT2, CYP2J2, CX3CR1, KLF2, CYBA, TRIB1, MAPK14, MIR494, NGFR, SLC17A3, GRAP2, HPSE2, CTLA4, PIN1, CRK, PLA2G1B, PLA2G2A, CACNA1A, NUBP1, PLAU, CARTPT, GAS5, SERPINF1, CD14, MIR335, IL37, RTN4R, ABCG2, NPR3, NPPA, GSTO1, TNFSF12-TNFSF13, NOTCH1, CHI3L1, ANGPTL3, CPOX, NTF3, AIM2, CDC42, TLR2, MIR17HG, TIMP2, EIF2AK3, CD69, PDE4A, RUVBL2, HPSE, SERPINF2, HABP2, ACE2, ABCG1, CKLF, APOH, AHSA1, OCLN, ALOX12, MIR499B, PPIF, ALB, CLEC1B, AHSG, APLNR, MARCHF1, TUG1, AGTR2, ADRB2, SST, NAMPT, SGK1, ADRA2B, PGR-AS1, ADM, ADD1, SLC5A2, SLC9A1, SLC12A2, CBSL, SIRT6, DUOX1, ACHE, STC1, AQP9, SULT1E1, PSMA6, TSPO, CXCL16, NGB, CYP2B6, PPARD, TGFA, PPID, DUOX2, SEMA3E, BCL2A1, MAPK8, PROS1, HNF1A, PTEN, AR, TBXAS1, ACKR3, PTGIS, ATM, MAFB, ARSA, ARG1, RAC1, MOK, SYK, MIR874, RBP4, RELA, CYP1A1, COX5A, MIR29B2, GRIA2, MIR134, KCNJ13, KCNQ1, RBM45, TSLP, TRPV1, FCGR2A, F12, AIMP2, HSPB2, VCAM1, MIR150, HSPB1, EZH2, MIR15A, ESR2, EPHB2, TNFSF12, GRIN1, HSPA1B, MIR181C, JUN, FGFR4, SNHG1, FGG, GFAP, GJA4, GLP1R, HSPA12B, RIPK1, IL15, BECN1, GCG, MIR106B, MIR107, MIR125A, IMPA2, GPER1, TIMD4, IRF4, HSPB3, MIR132, CXCR4, IFNG, NEIL1, MCU, HSPA1A, EPHA4, FADS1, DKK1, ECE1, MIP, MMP7, HGF, NQO1, CXCL2, CYP3A5, CYP3A4, TNFSF4, CFH, MIR27B, HDAC2, POU2F3, RNF19A, MIR29B1, MLKL, CYP2C8, MTR, MTRR, PDGFD, TXN, ULK1, COL18A1, LLGL2, SLC33A1, NR4A3, EGR1, RCOR1, LTA4H, EDNRA, NR3C1, IL9, COASY, PLA2G6, CRTC1, MGLL, MS4A4A, GNLY, STK26, IRAK4, MRAS, SORBS1, TLR8, CLEC16A, NTNG1, TLR7, MCF2L2, MLC1, ZC3HC1, CARD8, ARC, TBC1D9, VASH1, FAIM2, SPTBN5, MZB1, ATF6, NOX4, ACOT7, CAMKK2, UBQLN1, LILRB1, PLA2G15, DUSP14, SETD2, REM1, RIPK3, COPS5, HTRA2, STIP1, STK39, IL17B, BCL2L13, PANX1, PDIA5, NAAA, HAVCR1, FASTK, PRDX5, RNPS1, HECTD1, FAM98A, SLC17A5, DAPK2, SMUG1, ALDH1L1, TRAF3IP2, CXCR6, RMDN1, MLXIPL, VSIG4, PARK7, TREX1, GAL, NCS1, MASP2, FOXP3, PDE11A, PADI4, AK3, IL20, NOP53, TRS-AGA2-3, NES, CAPN10, SPIDR, MMD, MAPK8IP2, PLK2, RTEL1, A2M, ASIC5, MIR152, MIRLET7B, MIRLET7E, MIRLET7I, MIR106A, MIR125B2, MIR129-2, MIR130B, MIR140, MIR144, MIR17, LINC01194, MIR185, MIR192, MIR195, MIR199B, MIR200C, MIR206, MIR212, MIR216A, MIR219A1, CIMT, TSPYL6, NANS, NPAS4, CILP2, HJV, ARL6IP6, RMDN2, C5orf38, RMST, HSPA12A, IS1, COPD, H19, C11orf96, SNHG15, XKR6, MMAB, SERPINA9, FFAR4, C1QTNF9, ACTBL2, MAGEB5, PEAR1, MIR22, MIR221, MIR30D, MIR1203, MIR608, MIR618, MIR638, ZGLP1, MIR298, MIR922, KIR2DS2, DEFB4B, MIR1306, MIR664A, MIR31, HOTTIP, MIR4437, MIR4669, MIR4656, PTCSC3, EMSLR, LOC101929707, ERICD, LOC110673971, MIR605, MIR532, SCARNA6, MIR487B, MIR34A, MIR93, MIAT, POTEKP, ZFAS1, MIR326, PLF, MIR422A, MIR424, DEFB104B, MIR449A, MIR363, MIR451A, MIR410, MIR497, MIR503, POTEM, SNHG6, MIR544A, TTC7B, SRXN1, TRPM6, NLRC4, MRS2, NDRG3, NDRG2, NLN, TAOK1, SEMA6A, RNF213, PRX, HAMP, IL21, MARCHF7, TRPV4, PROK2, SRR, NEUROG2, CRLF2, MOAP1, ABCG8, GORASP1, SMURF2, RTN4, PDXP, ANKS1B, SPHK2, TOMM7, DLL4, EGLN1, UGT1A1, ROPN1, TRPM7, RASIP1, TMEM132A, ANO1, RMDN3, IMPACT, KIF16B, SYBU, VPS35, RNF130, ACSS2, APOM, LRRC8A, MMP26, NMNAT1, AGXT2, DEFB104A, METTL18, MINDY4, NTNG2, KDM2B, ACCS, PSRC1, IL17RC, ORAI1, DOCK7, OTULIN, SPECC1, PINK1, DNER, MUC16, TRIM9, LRG1, CYP2R1, ACOT4, FOPNL, TAF8, UBR3, TSPAN10, BCO2, PLVAP, QTRT1, ACD, NBEAL1, MARCKSL1, WNK1, WNK3, CYP4F12, MUL1, ADIPOR2, TNFAIP8L2, DHX40, EHMT1, MAP9, ERMP1, WLS, NAA25, ZC3H12A, FLAD1, KCNIP4, RNF146, AGR2, SLCO1A2, ATG7, VEGFD, GPT, GPX1, GRN, GRIK2, GRIN2B, GRIN2C, GRINA, GRM1, GRM2, CXCL1, GSTM1, GSTT1, HADHA, HCRT, HDLBP, HK2, HLA-B, HLA-C, HLA-DQB1, HLA-G, NR4A1, GPR42, GPR37, GPI, GATA3, FOXO3, FLG, FMO3, FOLH1, FOS, G6PD, GALNT2, GAP43, GATA1, GCH1, GOT2, GCKR, GEM, GGCX, GHRH, GJA1, GCLC, GLI2, GNAS, GNB3, HP, HES1, HSPG2, LIG4, KRT18, LAD1, LAMA5, LAMC2, LAMP2, RPSA, LCP1, LEPR, LGALS9, LIMK1, KIR3DL1, LOXL1, LRP1, LRP6, MAPT, MBL2, MDK, MDM2, CIITA, NR3C2, KIR3DL2, KIR2DS1, HTR1A, IL7R, HTR2A, ID2, IFIT3, IGF1R, IGFBP3, IKBKB, IL2, IL4R, IL5, IL10RA, KDR, IL10RB, IL16, TNFRSF9, INSRR, IRAK1, IRS1, ITGB2, JAK3, JUNB, FOXF2, FGF13, MRC1, FGF2, ARRB2, ATF3, ATF4, B2M, BARD1, CEACAM1, BHMT, BNIP3L, BRCA2, BRS3, BTF3P11, SERPING1, C5, VPS51, CACNA1C, CALM1, CALR, CALU, CASP1, CASP7, CASP8, AREG, ABCC6, AQP1, ADRA2A, ABCA4, ACACA, ACP5, ACTB, ACTG1, ACTG2, ACYP2, ADCYAP1, ADRA1A, ADRA2C, APOD, ADRB1, ABCD1, ABCD2, ANGPT2, ANK1, ANPEP, ANXA1, AOC2, BIRC5, CAT, CD28, CD34, ERCC4, EDN2, EDN3, EEF1A1, EFNB2, CELSR2, EGR2, EGR4, ELK1, EPAS1, ETS1, DLG2, ETV3, F7, F8, F9, FBLN1, FCGR3A, FCGR3B, FCN1, FGF1, DVL1, DLD, CD36, CRMP1, CD74, CDH13, CDKN3, CHIT1, CHRNA4, CIRBP, CCR5, COMT, CRHR1, CRYZ, DEFB4A, CSF2, NKX2-5, CTNNB1, CYP2B7P, CYP2D6, CYP2E1, CYP24A1, DECR1, DEFB1, MOG, MSD, IRF9, STAT5A, TRH, TRPC6, TRPM2, TRPS1, TTR, UBE2L3, UCHL1, UGCG, UGT2B4, UMOD, USF1, UTRN, VASP, VDR, VEGFB, VIP, VSNL1, VTN, WRN, ZNF208, MANF, TRAF3, TRC-GCA24-1, TNNI3, TERT, STIM1, ABCC8, SYT1, TAC1, ADAM17, ZEB1, TCN2, TEK, TERC, TFDP1, TNFRSF1A, TFPI, TGM2, THBS1, TIMP1, TLR3, TLR5, TM7SF2, CLDN5, TNFAIP3, REEP5, TFPI2, ARHGEF5, ADAMTS3, MSC, ASIC3, CD163, ZFYVE9, FADS2, HOMER2, HOMER1, FHL5, ADAMTS4, GTPBP1, XPR1, SNCAIP, PDE4DIP, HDAC4, XYLB, SLC23A2, CCS, NR1H3, EDIL3, EBI3, NOG, IL1RL1, AKAP1, PDE5A, BRAP, KLF11, GPR65, APOL1, PIAS1, DENR, MADD, TNFSF11, PLPP3, TNKS, LPAR2, ABCC3, TNFSF14, TNFSF10, TNFRSF11A, IL18RAP, IL18R1, NR1I2, SQSTM1, USP14, STAT5B, STAT4, MSR1, STAR, PCSK1, PDGFRB, PECAM1, SERPINE2, SERPINI1, PIK3R1, PITX2, PKM, PLIN1, PLP1, PNN, POR, POU2F1, PPBP, PPIA, PRH1, PRH2, PRKAR1A, PRKCA, PRKCD, PRKD1, SERPINA5, PC, PAPPA, NPC1, MTAP, CYTB, MUSK, MMUT, MVK, NDUFC2, NFKB1, NM, NNMT, NPPB, SERPINB2, NTF4, OATP1, OGG1, OPRK1, OPRM1, P2RX4, P2RX7, P2RY2, PAEP, MASP1, PSMB9, PTGDR, SLC20A2, ITSN1, SHC1, SHH, SHMT1, SLC6A4, SLC6A11, SLC6A13, SLC12A3, SLC19A1, SMN1, SELL, SMN2, SNCA, SNRNP70, SOD2, SOD3, SOX2, SREBF2, SRF, SSTR4, MAP2K4, SDC1, PTGER2, RPS20, PTGIR, PTHLH, PTMA, PTMAP4, RAPSN, RARRES2, RENBP, RGS7, RNASE3, RTN1, CX3CL1, SORT1, S100A9, S100A11, SAA1, SAA2, TSPAN31, CCL5, CCL19, CCL23, H3P7
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Gerstmann-Straussler Disease
Omim
The amyloid core of plaques was immunolabeled with antibodies raised to PrP, but not with antibodies raised to beta-amyloid (APP; 104760). Spongiform changes were mild. ... INHERITANCE - Autosomal dominant GROWTH Weight - Rapid weight loss late in the disease HEAD & NECK Eyes - Impaired smooth pursuit NEUROLOGIC Central Nervous System - Cerebellar ataxia - Gait ataxia - Truncal ataxia - Limb ataxia - Lower limb weakness - Dysarthria - Memory loss - Dementia (later onset) - Extrapyramidal signs (less common) - Parkinsonism - Rigidity - Bradykinesia - Tremor - Apraxia - Spasticity - Hyperreflexia - Myoclonus - Perseveration - Amyloid-like plaques, immunoreactive to PrP, predominantly in the cerebellum - Amyloid-like plaques are not immunoreactive to APP ( 104760 ) - PRNP-immunoreactive cerebral amyloid angiopathy (in some patients) - Neurofibrillary tangles may be present - Spongiform changes are mild or may not be present - Some patients have periodic wave complexes on EEG - Cerebellar atrophy Peripheral Nervous System - Dysesthesias of the lower limbs - Loss of deep tendon reflexes Behavioral Psychiatric Manifestations - Personality changes - Aggressive behavior - Emotional lability - Depression - Psychosis MISCELLANEOUS - Adult onset, usually 30's to 40's, but up to early 60's - Rapidly progressive, but slower than Creutzfeldt-Jakob disease ( 123400 ) - Average disease duration of 7 years - Longer disease duration than Creutzfeldt-Jakob disease - Variable phenotype MOLECULAR BASIS - Caused by mutation in the prion protein gene (PRNP, 176640.0002 ) ▲ ClosePRNP, G6PC, C4BPA, PRDX2, ABCB6, CARD14, SLC37A4, PHKA2, APOE, SI, MGAM, APOB, TSHZ1, GCA, BTD, ABCG8, PYGM, CDHR5, NT5C3A, MED18, LINC01193, NCOA6, ECD, ABCG5, H3P36, TRAF3, H3C9P, HNF1A, POLDIP3, ROS1, SYNE1, ACHE, PYGL, PLCL1, ANXA2, APP, APRT, CCKAR, CSF3, CTLA4, CYP7A1, FABP2, GBE1, GH1, GNAS, GYG1, GYS2, IL6ST, LRPAP1, MAPT, MB, MDH1, MFAP1, MNAT1, ADRA2A, FAS-AS1
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Oligodendroglioma
Wikipedia
. ^ NEJM 867-5309, ed 6, p112–116, Kevin Smith etal ^ http://www.reseau-pola.org/app/download/24869531/La+Lettre_RENOP_5.pdf ^ Louis D, Ohgaki H, Wiestler O, et al. (2007). ... External links [ edit ] Classification D ICD - 10 : C71 ICD - 9-CM : 191.9 ICD-O : M9450/3 -9451/3 MeSH : D009837 DiseasesDB : 29450 SNOMED CT : 443936004 External resources eMedicine : neuro/281 Orphanet : 251627 Brain and Spinal Tumors: Hope Through Research (National Institute of Neurological Disorders and Stroke) CT and MR Scans Classic Radiology Imaging of Oligodendroglioma http://www.reseau-pola.org/app/download/24869531/La+Lettre_RENOP_5.pdf v t e Tumours of the nervous system Endocrine Sellar : Craniopharyngioma Pituicytoma Other: Pinealoma CNS Neuroepithelial ( brain tumors , spinal tumors ) Glioma Astrocyte Astrocytoma Pilocytic astrocytoma Pleomorphic xanthoastrocytoma Subependymal giant cell astrocytoma Fibrillary astrocytoma Anaplastic astrocytoma Glioblastoma multiforme Oligodendrocyte Oligodendroglioma Anaplastic oligodendroglioma Ependyma Ependymoma Subependymoma Choroid plexus Choroid plexus tumor Choroid plexus papilloma Choroid plexus carcinoma Multiple/unknown Oligoastrocytoma Gliomatosis cerebri Gliosarcoma Mature neuron Ganglioneuroma : Ganglioglioma Retinoblastoma Neurocytoma Dysembryoplastic neuroepithelial tumour Lhermitte–Duclos disease PNET Neuroblastoma Esthesioneuroblastoma Ganglioneuroblastoma Medulloblastoma Atypical teratoid rhabdoid tumor Primitive Medulloepithelioma Meninges Meningioma Hemangiopericytoma Hematopoietic Primary central nervous system lymphoma PNS : Nerve sheath tumor Cranial and paraspinal nerves Neurofibroma Neurofibromatosis Neurilemmoma / Schwannoma Acoustic neuroma Malignant peripheral nerve sheath tumor Other WHO classification of the tumors of the central nervous system Note: Not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain (see brain metastasis ).IDH2, IDH1, POT1, HEY1, TP73-AS1, HES1, GDNF, DTX1, OLIG2, TP53, EGFR, MGMT, CDKN2A, CIC, GFAP, FUBP1, ATRX, PTEN, TERT, ARHGAP24, BRAF, LOC110806263, TP73, MKI67, MIB1, SYP, CDKN2C, PDGFRA, INA, H3P10, CAV1, BCL2, FGFR1, CDKN2B, IGFBP2, MBP, NOS1, MIR409, PIK3CA, CDK2, AJAP1, STAR, SST, BICRA, CIB1, CD44, HTC2, NOTCH2, IL2, PTPRZ1, BCAN, NOS2, MDM2, MET, CACNA1F, PTGS2, MIR137, KIAA1549, GSTT1, CNTN2, CTNNB1, DCX, DSC3, VEGFA, OLIG1, CDKN1B, DES, BEX2, COX8A, KLF6, CSPG4, AP5Z1, H3C3, LRIG2, H3C4, H3C1, EDIL3, ADAM12, RIMS2, ZNF197, MIR379, CCNO, TUBB3, NDC80, LHX3, MRPL28, MELK, PRDX6, RGS6, MIR656, H3C2, DUX4, H3C10, RAD54L, H3C12, CUL3, CNTNAP1, H3C8, PSMG1, PTCH2, MXD4, TSC22D1, HNRNPA1P10, H3C7, DIRAS3, H3C11, H3P12, MIR487B, GDF15, EEF1E1, RAB3D, H3P9, H3C6, ZNF296, MIR134, IGF2BP3, GEMIN7, ATAD3A, HES6, ZAR1, TBATA, RTN4, GPR158, PRSS55, PARVG, SOX17, DERL1, MINDY3, ATAD2B, PPP1R2C, CITED4, ATAD3B, NKX6-2, SPZ1, MTDH, NAPRT, MAL2, CSMD2, TPPP2, LAMTOR1, ATRAID, NES, CNTNAP2, ARPP21, HPSE, SUB1, MYT1L, KIF1B, XRCC6P5, PLCB1, RYBP, SLC5A8, LRIG1, LATS2, WT1-AS, ANKRD1, GLS2, ARHGEF16, GPR162, BTG2, TSPAN33, NXT1, NOP53, NT5C, FOXP3, MAFK, ACLY, PRDM2, DNASE1, DUSP2, DYRK1A, EDNRB, EMP3, ENO2, EPAS1, EPHB2, ERCC2, ETV4, EZH2, FGF2, FLT1, AFF2, FXN, GLUL, ARHGAP35, GSTM1, GSTP1, MSH6, H3-3A, H3-3B, HMGB1, HNRNPA1, HSPG2, TNC, ATN1, DMBT1, IL13, DFFB, ADCYAP1R1, ADM, AKT1, ANXA1, APC, BIRC5, ARHGDIA, ASCL1, CCND1, BCL2L1, CA8, CA9, CD34, CD63, CDH1, CDK4, CFL1, CHI3L1, CNP, MAP3K8, CPE, CREB1, CSE1L, DAP, DAPK1, IL2RB, ITGA2B, ZAP70, RB1, S100A4, SDHB, SLC1A1, SLC2A1, SLC9A1, SMARCA2, SMARCA4, SMARCB1, SNCB, ACTB, SOX10, SULT1E1, AURKA, SULT2A1, SYN1, THBS1, TIMP4, TNF, TNR, CRISP2, TYK2, TYROBP, UBE2I, UGT8, VIM, REST, RASA1, KCNA5, RAC1, STMN1, LGALS1, LGALS3, MCM6, CD99, COX2, MMUT, NF2, NKX2-2, NOTCH1, NPY, PAX6, PCNA, PDE3B, PDGFA, PEG3, PIK3CB, PIK3CD, PIK3CG, PLG, POU3F1, MAPK1, PSMA5, PTAFR, PTPN6, SOX2
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Aa Amyloidosis
Wikipedia
External links [ edit ] Classification D ICD - 10 : E85 ICD - 9-CM : 277.3 DiseasesDB : 16 External resources eMedicine : med/3388 UK NHS National Amyloidosis Centre Patient Information Site: information on AA amyloidosis v t e Amyloidosis Common amyloid forming proteins AA ATTR Aβ2M AL Aβ / APP AIAPP ACal APro AANF ACys ABri Systemic amyloidosis AL amyloidosis AA amyloidosis Aβ2M/Haemodialysis-associated AGel/Finnish type AA/Familial Mediterranean fever ATTR/Transthyretin-related hereditary Organ-limited amyloidosis Heart AANF/Isolated atrial Brain Familial amyloid neuropathy ACys+ABri/Cerebral amyloid angiopathy Aβ/Alzheimer's disease Kidney AApoA1+AFib+ALys/Familial renal Skin Primary cutaneous amyloidosis Amyloid purpura Endocrine Thyroid ACal/Medullary thyroid cancer Pituitary APro/Prolactinoma Pancreas AIAPP/Insulinoma AIAPP/Diabetes mellitus type 2 (www.AmyloidAware.com ) Booklet and explanatory video explaining the difference between the types of amyloidosis.
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Endogenous Depression
Wikipedia
Endogenous depression (melancholia) is an atypical sub-class of the mood disorder , major depressive disorder (clinical depression). It could be caused by genetic and biological factors. [1] Endogenous depression occurs due to the presence of an internal (cognitive, biological) stressor instead of an external (social, environmental) stressor. [2] Endogenous depression includes patients with treatment-resistant, non-psychotic, major depressive disorder, characterized by abnormal behavior of the endogenous opioid system but not the monoaminergic system . [3] [4] [5] [6] Symptoms vary in severity, type, and frequency and can be attributed to cognitive, social, biological, or environmental factors that result in persistent feelings of sadness and distress. Since symptoms are due to a biological phenomenon, prevalence rates tend to be higher in older adults. [7] Due to this fact, biological-focused treatment plans are often used in therapy to ensure the best prognosis. [2] Contents 1 Signs and symptoms 2 Risk factors 3 Treatment 4 Prevalence 5 History 6 See also 7 References 8 External links Signs and symptoms [ edit ] The forefront indication that a depressive episode is manifesting is the sudden loss of energy or motivation in daily routines. [8] [9] When this occurs, it is not uncommon for individuals to seek medical attention with excessive worrying or anxiety that a more severe, physiological disease may be the underlying issue. [8] However, without an actual disease present, this neurotic thinking often results in severe anxiety, sleep disturbance, and mood swings which may hinder social relationships. Individuals with endogenous depression may experience inconsistencies in symptom severity [10] which is often the reason for delayed treatment. [8] If left untreated, symptoms may progress to a major depressive episode. Risk factors [ edit ] Endogenous depression occurs as the results of an internal stressor—commonly cognitive or biological—and not an external factor.TPH2, DISC1, CRH, POMC, ADORA2A, PTGS2, MIF, MTHFR, NOS1, NPY, NPY1R, PDCD2, PON1, RELN, SELP, S100A10, ALB, SLC6A4, SNAP25, SOD1, TG, PDCD6, CADM1, GHRL, DIXDC1, KCNK2, IL6, IFNA2, FTH1, APP, BDNF, CNR2, CREBBP, CSF3, DRD5, ACSL4, HTR7, FGFR1, FGF2, FTL, GLO1, GNAS, GNB1, NR3C1, GSK3A, GSK3B, HAP1, MORC1, DBH, COMT, HLA-B, HLA-C, ECT
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Parkinson Disease 4, Autosomal Dominant
Omim
They noted that the disease process may resemble the etiology of Alzheimer disease (AD; 104300) in Down syndrome (190685) with overexpression of the APP gene (104760) due to chromosome 21 trisomy.
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Amblyopia
Wikipedia
Also, the chance of achieving 20/20 vision is greater if treatment is initiated early. [39] One of the German public health insurance providers, Barmer, has changed its policy to cover, as of 1 April 2014, the costs for an application for amblyopic children whose condition has so far not improved through patching. The app offers dedicated eye exercises that the patient performs while wearing an eyepatch. [40] Evidence for vision therapy is unclear as of 2011. [41] Older age [ edit ] Tentative evidence shows that perceptual training may be beneficial in adults. [42] [43] Epidemiology [ edit ] Amblyopia occurs in between 2 and 5% of the population in Western countries [ which? ... BMJ . 324 (7353): 1549. doi : 10.1136/bmj.324.7353.1549 . PMC 116606 . PMID 12089090 . ^ "App auf Rezept: Barmer bezahlt internetbasierte Behandlung" [Prescription app: Barmer pays for internet-based treatment]. www.aerztezeitung.de (in German). 28 March 2014.PPARGC1A, FGFR3, ACVRL1, AP4E1, SMCHD1, PUF60, AP4S1, YME1L1, AP4B1, TUBB3, WARS2, MAFB, CHST3, ARHGEF2, AP4M1, OGT, TWIST1, TRIO, TFAP2A, ADNP, PIGN, PHOX2A, B3GAT3, NPHP3-ACAD11, LAMA1, TSEN54, NPHP4, IRAK1BP1, MTFMT, LOXL3, COL25A1, TRIM8, WDR26, UBA5, XYLT2, PHIP, P4HTM, NDUFB11, ADAMTSL4, GMPPB, TBX1, SMARCB1, PTPN11, COL9A1, DPP6, CRYGC, CRYAA, COX7B, COL11A1, COL9A3, COL9A2, COL4A1, ERF, LYST, CHN1, CBS, CACNA1F, CACNA1E, CACNA1A, C1QBP, ENG, EPRS1, FBN1, LIM2, PITX2, PAX6, OCRL, GPR143, KMT2A, SMAD4, KIF11, HCCS, H1-4, GNAS, GDF2, GALC, FGFR2, VIP, MBD5, IRF1, PLXNA2, RBM19, CRYBB1, BCHE, COMETT
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Familial Amyloid Polyneuropathy
Wikipedia
External links [ edit ] Classification D OMIM : 105210 External resources eMedicine : article/335301 GeneReviews/NIH/NCBI/UW entry on Familial Transthyretin Amyloidosis v t e Amyloidosis Common amyloid forming proteins AA ATTR Aβ2M AL Aβ / APP AIAPP ACal APro AANF ACys ABri Systemic amyloidosis AL amyloidosis AA amyloidosis Aβ2M/Haemodialysis-associated AGel/Finnish type AA/Familial Mediterranean fever ATTR/Transthyretin-related hereditary Organ-limited amyloidosis Heart AANF/Isolated atrial Brain Familial amyloid neuropathy ACys+ABri/Cerebral amyloid angiopathy Aβ/Alzheimer's disease Kidney AApoA1+AFib+ALys/Familial renal Skin Primary cutaneous amyloidosis Amyloid purpura Endocrine Thyroid ACal/Medullary thyroid cancer Pituitary APro/Prolactinoma Pancreas AIAPP/Insulinoma AIAPP/Diabetes mellitus type 2
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Phantom Vibration Syndrome
Wikipedia
Retrieved September 4, 2011 . v t e Mobile phones mobile networks , protocols Channel capacity Frequencies Multi-band Network operator list Roaming Signal SIM card dual SIM SIM lock Standards comparison Tethering VoIP WAP XHTML-MP generations analogue : 0G 1G digital : 2G 3G adoption 3.5G 4G 4.5G 5G 6G general operation Features GSM services History Operating system Security phone cloning Telephony airplane mode Text messaging SMS MMS RCS Spam Tracking Web browsing mobile devices Manufacturers 3D phone Camera phone Car phone Feature phone Projector phone Satellite phone Smartphone form factors Bar Flip Phablet Slider Smartwatch smartphones Android devices rooting BlackBerry 10 iPhone iOS jailbreaking Open-source mobile phones Symbian devices Windows Phone devices mobile specific software apps Development Distribution Management Cloud computing commerce Banking Marketing advertising campaigns Payments contactless donating Ticketing content Blogging Email Gambling Gaming Health Instant messaging Learning Music News Search local Social address book Television culture Box breaking Charms Comics Dating Japanese culture Novels Ringtones silent mode Selfie Txt-spk Wallpaper environment and health BlackBerry thumb Driving safety Electronic waste External power supply Mental health from overuse Phantom vibration syndrome Radiation and health Recycling law Carrier IQ Legality of recording by civilians Mobile phones in prison Photography and the law Telephone tapping Texting while driving USA use restrictions while driving Category Portal
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Paralysis
Wikipedia
"Paralysed" redirects here. For other uses, see Paralysed (disambiguation) and Paralysis (disambiguation) . "Paralytic" redirects here. For the gene, see Paralytic (gene) . Not to be confused with Spasticity , Sensory loss , Numbness , Hemiparesis , or Spastic hemiplegia . This article needs additional citations for verification . Please help improve this article by adding citations to reliable sources . Unsourced material may be challenged and removed. Find sources: "Paralysis" – news · newspapers · books · scholar · JSTOR ( January 2010 ) ( Learn how and when to remove this template message ) Paralysis Specialty Neurology , neurosurgery , psychiatry Paralysis (also known as plegia ) is a loss of motor function in one or more muscles . Paralysis can be accompanied by a loss of feeling (sensory loss) in the affected area if there is sensory damage as well as motor.TRPM7, BCHE, SIRT1, UNC45B, MOG, CHRND, INS, ATP7A, APP, PYGM, SLC12A3, SOD1, OPTN, TAF15, CNTNAP1, SQSTM1, VAPB, MATR3, SLC2A1, FIG4, VCP, ALOX12B, PPARGC1A, PDCD10, UNC13A, TARDBP, CHMP2B, HSPB8, TBK1, UBQLN2, TREM2, GLT8D1, ALOXE3, SLC25A19, C9orf72, ATXN2, PPOX, PRPH, ANG, ANXA11, CFAP410, CCNF, CD59, CLCNKB, DAO, DCTN1, EPHA4, ERBB4, FGFR1, FUS, GLE1, GM2A, HFE, HK1, HNRNPA1, HSPB1, KRAS, NEFH, NEK1, PFN1, POLG, PON1, PON2, PON3, CHCHD10, ROBO3, ALS2, PMP22
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Chmp2b Frontotemporal Dementia
Gene_reviews
Genes of Interest in the Differential Diagnosis of CHMP2B Frontotemporal Dementia ( CHMP2B -FTD) View in own window Gene(s) Disorder MOI Clinical Features of Differential Diagnosis Disorder Overlapping w/ CHMP2B -FTD Distinguishing from CHMP2B -FTD APP PSEN1 PSEN2 1 Early-onset familial Alzheimer disease (EOFAD) AD Mild behavioral changes Prominent memory disturbance Loss of initiative Word-finding problems Absence of focal frontotemporal atrophy on neuroimaging C9orf72 C9orf72 -ALS/FTD AD Adult-onset rapidly progressive features of FTD, ALS, or a combination of both May not be clinically distinguishable Psychotic symptoms more common in C9orf72 -ALS/FTD FUS ALS 6 w/or w/o FTD AD MND w/FTD Familial ALS w/o FTD Onset before 5th decade Incomplete penetrance GBA SNCA SNCB Lewy body dementia (OMIM 127750) AD Dementia Extrapyramidal signs (rigidity, bradykinesia) REM sleep disorders Visual hallucinations DaT scans abnormal GRN GRN -FTD AD Adult-onset behavioral-variant FTD Generally affects frontal & temporal cortex, → behavioral changes, executive dysfunction, & language disturbances Parietal cortex & basal ganglia may be affected as well, resulting in parkinsonism, cortical basal syndrome, & memory impairment Age of onset: 48-83 yrs Clinically indistinguishable Metabolic changes (on FDG-PET) preceding structural changes of frontal atrophy (on MRI) HTT Huntington disease AD Changes in personality (apathy or depression) Cognitive decline Dementia Dystonia Chorea Delusions Visual hallucinations MAPT FTD w/parkinsonism-17 (OMIM 600274) AD Adult-onset behavioral variant FTD Extrapyramidal signs (rigidity, bradykinesia, supranuclear palsy, & saccadic eye movement disorders) Symptoms usually start at ages 40-60 yrs but may occur earlier or later. ... It is likely that pathogenic variants in other genes causative of EOFAD will be identified because families with autosomal dominant FAD with no known pathogenic variants in PSEN1 , PSEN2 , or APP have been described [Pasanen et al 2018]. 2.
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Major Affective Disorder 5
Omim
For a phenotypic description and a discussion of genetic heterogeneity of bipolar disorder, see 125480. Mapping Jamra et al. (2007) performed a genomewide interaction and locus heterogeneity linkage scan in bipolar affective disorder (BPAD), using a large linkage dataset (52 families of European descent; 448 participants and 259 affected individuals). The results provided the strongest evidence of interaction between BPAD genes on chromosome 2q22-q24 (MAFD5) and 6q23-q24 (MAFD6; 611536), which was observed symmetrically in both directions; nonparametric lod (NPL) scores of 7.55 on 2q and 7.63 on 6q; P less than 0.0001 and P = 0.0001, respectively, after a genomewide permutation procedure. The second-best BPAD interaction evidence was observed between 2q22-q24 and 15q26. Here, Jamra et al. (2007) also observed a symmetric interaction. Whereas chromosome 6q23-q24 showed evidence within the 1-dimensional linkage scan, the chromosome 2q22-q24 locus was detectable only in the 2-dimensional linkage scan.HTR2A, S100B, ANK3, CACNA1C, COMT, NCAN, SP4, ADCY2, POLG, FADS2, LMAN2L, GAD1, GSK3B, SLC6A4, DRD1, BDNF, ITIH1, CLOCK, NR3C1, MTHFR, NDUFV2, GRIN2A, RELN, ACE, GRK3, PDE4B, DRD5, SNAP25, ATP1A3, CAMK2A, TACR1, NTRK2, POU3F2, POMC, INS, AKR1C4, BHLHE40, GRIK2, SERPINA1, NTNG2, NRG1, ZNF804A, DGKH, CHRNA7, TENM4, SYNE1, TCF4, ATP2A2, SLC25A4, PBRM1, CACNB2, TRANK1, PDE10A, CSMD1, NFIX, TSPAN8, LINC02694, TCF7L2, NLGN1, PALB2, ITIH3, SEC24C, FEZ1, ZCCHC2, P2RX7, RPS6KA2, TH, XBP1, TNF, RIMS1, PACS1, SLC6A3, MAOA, CD47, DRD3, DRD2, SCN2A, DAOA, TPH2, STARD9, IL6, SHANK2, DISC1, NEK4, ADD3, PC, SSBP2, HDAC5, THSD7A, IMPA2, AKT1, GRIN2B, PDLIM5, DRD4, FKBP5, DTNBP1, HTR2C, ARNTL, TRPM2, ERDA1, KCNN3, SLC1A2, BRD1, IL1B, WFS1, CSNK1E, DAO, TPH1, HTR1A, PPP1R1B, GRIK4, BCL2, PER3, ST8SIA2, DAOA-AS1, IGFBP2, PLA2G1B, PVALB, GRM3, MIR137, TIMELESS, RGS4, GRN, APOE, DUSP6, PON1, DDC, ALDH2, RORA, GRIN1, NCAM1, GPR50, IGF1, NR4A2, MMP9, TSNAX, GPRC5D, SLC6A2, HTR3B, SYNGR1, PIP4K2A, GDNF, TSPO, CXCL8, IMPA1, ESR1, NR1D1, INPP1, ADCYAP1, HPGDS, MAPK1, HSP90B1, GABRA5, GABRA3, G6PD, ERBB4, DPYSL2, HTR3A, CRHR1, SYN2, CALB1, TLR2, SIRT1, NOTCH4, DBH, AVPR1B, GRM7, YWHAZ, CHRFAM7A, DLG3, CREB1, SOD1, TLR4, GRM5, GRIK1, DNAJB1, PRKCI, PTPA, ITPR1, MC2R, PSEN2, HTR1B, HSPA5, HSPA4, PFKL, NOS3, GRIA3, FYN, GNAL, PROKR2, HLA-G, SORCS2, NPAS2, GSTM1, GRIA2, HTR5A, IL1RN, PCNT, NRGN, PLA2G2A, GFAP, NTF3, PLA2G4A, GCH1, GSTT1, GRIA1, SLC12A6, MIR212, SLC18A2, SST, PGP, CTLA4, WHRN, CRY1, CRH, NCS1, CNR2, CNR1, CHRNB3, CUX2, VIP, YWHAE, CALCA, CACNA1D, BCR, PLA2G6, BAG1, NAPG, TSNAX-DISC1, ASMT, PER2, NRG3, NDST3, NRXN1, ADRB2, ADCY8, ADARB1, RASGRP1, SOD2, KCNQ2, SAT1, SLC1A3, KCNQ3, RFX4, ANKK1, MDGA1, EGR2, S100A10, EGR3, F9, FABP7, DCLK1, NPAS3, MMP10, VAPA, MAGI1, HIP1R, MTHFD1, REN, ABCB1, ND1, PSPN, MMP3, MTR, RTN4, CNTN6, PREP, IFT27, KLK8, AKAP10, ATF5, NTNG1, VAMP3, NR3C2, PCLO, GPRIN2, HMGXB4, MPPE1, MAGI2, USP46, TOM1, RAPGEF5, ERVW-1, RNF41, MAOB, ZDHHC8, MC5R, CLEC10A, TSHZ1, DBNL, NCOR2, CARTPT, RARA, LHX5, MFGE8, HCG9, RASGRF1, NOD2, TRPC7, FZD4, SLC17A6, TAC1, NR2E1, LARS2, ST3GAL1, TLL2, TGM2, AHI1, SEZ6L, TDO2, SLC1A4, PAH, PAWR, NDUFV1, SRRT, VAMP2, CNTNAP2, SSTR5, PIK3C3, SPR, PDE4A, SLC18A1, PDYN, SMS, DOCK9, PI4K2B, OTX2, IMPACT, GPR78, PGAM1, SYN3, STAB1, NEDD4, SLC17A7, MLC1, DOK5, NNMT, MBD5, YWHAH, SCN8A, PLCG1, VGF, VEGFA, VDR, PTGDS, UCP2, CCL2, TRPC3, TPO, SLC39A3, TGFB1, MBL2, FKBP1A, BCL9, ABCA13, ALOX12, BID, PPIEL, HLA-DRB1, BRCA2, ERBB3, C9orf72, AGT, SLC22A16, GRK2, S1PR1, AFG1L, DSCAM, MCHR2, DCTN5, FGFR1, BCHE, DNAH8, AVP, CBLIF, GLO1, ATF4, GRIN3A, APOD, MCHR1, GABRB3, GRIA4, GRIK3, GABRB2, GABRB1, GABRA1, FMR1, FOXO3, ATP1A2, GSTZ1, MIR2682, DNMT1, SP8, CSNK1D, CASP8, MIR206, IFNG, TAAR6, ACTB, CCKAR, CRHBP, CSRP1, CALM2, ADRA2C, CRY2, CBS, ISL1, ITGA9, CRHR2, IFNA1, ITGAM, DIO2, CHRM2, DLX1, DLG4, CHRM3, GABRR2, ARRB2, PRODH, PMCH, GAP43, CHRNA2, HCAR3, FOXP3, CDH17, PPP2R2C, FGF17, TSHB, GAD2, PRKCZ, PLCXD3, GABRG1, GAL, GABRR1, CDH7, PPID, PLEKHO1, PPP3CC, CACNA1B, ATP1A1, SRSF3, CACNA1A, SLC6A13, DLG2, FGF20, SLC5A3, SLC1A6, FBXL3, EHHADH, SLC1A1, SRPK2, DAZAP1, CPLX2, SFRP1, PHETA1, CACNG5, DKK4, CALR, PLCB1, DBN1, ASTN2, BDKRB2, DGKB, VIPR2, CNTN4, STK4, FGFR2, CPLX1, PPARD, BHLHE41, ME2, HLA-DRB4, ULK4, LBX1, NDUFV3, ITIH4, RACK1, GLYAT, NEFM, MAP2, NEFL, IL2RB, HLA-E, MLLT3, ZNF592, ROR1, ADM, NTRK1, ARHGEF10, HIF1A, HINT1, SEPTIN11, DIXDC1, GSK3A, GRM4, TUBA8, KCTD12, ADRA1A, CHRNA6, MRPS33, ADCY3, FSTL5, PFKFB3, ACADS, HTR4, LDHA, PDE9A, GNB3, AKT2, CHMP1B, TMSB10, GNB1L, GRID1, ARNTL2, GRIK5, C14orf28, PIP4K2C, APP, MAD1L1, CAMKMT, FXR1, MKLN1, ABCG1, PRR5-ARHGAP8, HLA-A, EGFR, SESTD1, MECP2, CACNB3, ASCC2, MYO5B, CNNM2, SOX2-OT, FADS1, LAMP3, LINC00461, MMADHC-DT, LHFPL3-AS1, TSBP1-AS1, SDCCAG8, ADCY1, LINC00243, DMTF1, LINC01748, LINC02033, CDC25B, MIR137HG, LINC01643, LINC01121, LINC02822, TRAF3IP2-AS1, JADE2, HDAC9, HIRA, RPRD2, UFD1, LINC02109, DOCK4, SMIM4, LINC01470, LAMA4-AS1, ATP2B2, POLG2, NUMB, TAF9BP2, AMPD3, CTSF, BORCS7-ASMT, TLCD4-RWDD3, EBNA1BP2, RERE, ACTL7A, LINC02384, ALOX12-AS1, TSBP1, USP8, IQCH-AS1, PROM1, MAU2, ASAP2, ARVCF, MGAT4A, ALOX12P2, BABAM2, CUL4A, TRIM26, MRPL33, DDN, KCNMB2, AKAP6, RASAL2, CUBN, LINC01592, FER1L6, KMT2D, SLC25A17, IPO8, IGSF9B, NT5C2, LINC01358, ARHGEF15, SLC8A1-AS1, CMAHP, SPTLC1, SFTA2, FA2H, CEP85L, PDE3B, GLT8D1, HLF, WDR12, HLA-DMB, HLA-DMA, ATP6V1E2, GULOP, RNLS, CABLES1, GSS, ARHGEF10L, RASIP1, TMEM132C, PGAP3, PCDH12, CSMD2, KDM3B, MPP6, SLC25A26, GP1BB, PIK3C2A, GFRA2, MTERF4, PLCB4, MUCL3, PHF7, NEK7, MACROD2, TWNK, NFYC, ANKS1B, KIF15, BCL11B, LMO7, STT3A, IQCH, DEPTOR, GIGYF1, C11orf80, MCTP1, GRTP1, CARF, RBKS, CDH23, CCDC102B, CCDC170, GRAMD1B, AS3MT, UXS1, SPG11, TMPRSS5, SLC4A10, SMIM8, ZNF93, ZCCHC7, ZNF577, PARP10, NFIA, CGNL1, COMMD10, FAM178B, LHFPL3, DNMT3A, SMPD1, GSDME, ZBTB20, ZNF740, MYO1H, TRPC4AP, MYRF-AS1, LTN1, KSR2, SNED1, FAM177A1, INTS7, TTLL6, ARHGAP8, CRP, TBX1, ZNF615, TCF3, DCBLD1, TRIM42, SEC11A, GRIP1, RFESD, ZFPM2, SLC35F4, TLE4, CLCN4, SLIT1, CADM2, KLHL23, SPCS1, RRM2B, ZNRD1, CPNE8, FLI1, PTPRG, PTS, C11orf21, MACROD1, CDAN1, TLCD4, RARRES2, CFAP57, RASGRF2, GNL3, PCDH15, FBLN1, RBMS3, RPN2, FER1L6-AS2, RPS6KA3, OTUD7A, RREB1, RXRG, PRSS35, ADAMTS16, ERBB2, STX2, JMJD1C, ASCC1, H3P40, NFKB1, ARHGEF7, CD40, EIF4EBP1, NOS1, DLX4, IL1A, LEP, NOS2, SHANK3, LOC110806262, CTNNB1, MIR34A, TMTC1, MAFD2, GPRC5C, MDD1, MZB1, ADIPOQ, CACNG2, PLB1, FAAH, BPI, STIN2-VNTR, FGF9, PRPF6, GRB2, HRAS, NGF, ACACA, BDNF-AS, CCK, THOP1, TLR1, COX2, PTPN5, HLA-C, CAT, IL4, EXOSC6, NLRP3, CYP2D6, FAT1, ETV5, HDGFL3, EPHB2, PTGS2, PGC, MINDY2, IL10, P2RY2, DISC2, CD36, P2RY1, P2RX5, P2RX4, P2RX3, P2RX1, RASSF7, CXCR3, NRAS, SHC4, NR4A3, ACSL4, KMO, PDLIM7, SYNJ1, FASTK, FTO, HOMER1, PPARGC1A, ENDOU, MAFD6, HTR1F, KL, IL18R1, P2RX5-TAX1BP3, P2RX6, NPL, APOB, MAFD4, MAFD1, MIR708, MTCO2P12, PLA2G10, EBI3, CAMKK2, HSPD1, BMS1, P2RX2, MSMB, LINC00273, SLITRK2, GDF10, IDH3A, GPR151, IDH2, FLAD1, GATA3, GC, PWAR1, BPIFA2, SVEP1, PPM1K, EHMT1, IGHG3, IFNA13, CKAP2L, FKBP1AP1, FKBP1AP2, GALC, FKBP1AP3, BICC1, IDH3B, PNPLA3, FKBP1AP4, FUT3, PPP1R2C, MRGPRX4, RBM45, GLP1R, HPT, HSPE1, HPN, HMGB1, LMLN, HSPG2, HCRT, HTC2, HTR1E, HBA2, TMPRSS13, MIXL1, HBA1, GTF2A1, PARP9, GRM1, HTR6, NDEL1, HTR7, GPX3, IDH1, FBXO32, GPER1, UTS2R, MRGPRX3, HSPA1L, TWIST2, GOT2, GNAZ, HLA-DRA, DGCR2, KCTD7, CAV2, FAS-AS1, LINC00271, ATP1B3, C20orf181, OPN1SW, PSS, OIP5-AS1, CA5A, CALM1, CALM3, CAMP, SCZD12, MIR504, MIR497, MIR346, GPR166P, VN1R17P, CAV1, NPIPB7, TNFSF12-TNFSF13, MIR29C, ASTN1, SCZD13, BACE1-AS, ADCYAP1R1, ASIC2, ACO1, ACO2, THRA1/BTR, TEMPS, TPTEP2-CSNK1E, ACP1, ACTA2, ADCY9, ADORA1, FAS, AGRP, ALAS1, CCAT2, AMD1, AMPH, ANG, SLC25A6, APOA1, LINC01672, MIR223, MIR195, F2R, MIR184, CSF2, HCCAT5, CUX1, DDIT3, OR10A4, DNMT3B, DNTT, MRGPRX1, LRRC57, DPYS, DRP2, DUSP2, GPRC6A, EGR1, OPN5, ZUP1, EPO, ESR2, OXER1, KANK4, EVC, ENDOV, CRMP1, ZNF493, CEACAM5, MIR149, MIR146A, MIR144, KRIT1, MIR132, PHOBS, CD14, CDH13, CDSN, CHI3L1, CPOX, CISH, CCR5, NANOS3, GOLGA6A, COL2A1, GADL1, COL9A3, KLF6, COX8A, DEFB1, SCZD10, IL18, TGFB2, PART1, TPSG1, QPCT, TBC1D22A, ADAM17, TAGLN, TERT, SMUG1, LPAR3, TG, THRA, RPL29, TLR5, TNR, TP53, TPI1, TSHR, RPGRIP1L, TYR, ADGRL3, ANKRD12, UBC, SYP, VAMP7, SOSTDC1, SH2B1, RPS23, IL17C, S100A11, CYTH4, SCD, SDHC, SGCG, SND1, HAVCR1, ST3GAL3, PMEL, SORL1, SOS1, SREBF2, ST13, STAR, STAT1, STAT5A, SS18L1, STAT5B, STXBP3, VRK2, VTN, CXCR4, UTS2, NR1I2, CHL1, WASF1, ZMYM3, ARID3B, MTA2, KAT5, CAP2, COX5A, PPIE, MICU1, TLR6, SIGMAR1, LITAF, GDF15, RIDA, BAG3, SOCS5, NOS1AP, CEBPZ, SART3, HPSE, RAB40B, ARHGEF5, RIPK2, MAPK8IP3, TBC1D9, VWA8, TAF15, SLC14A2, TPX2, BRAP, FZD7, ZNF365, FNDC3A, PKP4, PDLIM4, COPE, PARK7, SCN11A, PSMG1, SOCS1, TNFSF12, NISCH, CIT, TNFSF10, PCDH17, RORB, INSRR, NDUFS1, SEMA6A, LRRC7, NUFIP2, MST1, COX1, ND4, MTNR1B, MTRR, MUSK, NDUFA6, NFATC3, RIT2, NFE2L2, DTWD1, NFKB2, NGFR, PCDHA1, SNU13, NHS, NOTCH3, ATF7IP, NPTX1, DPP10, LRRC4C, MAGEE1, HAMP, ITGB4, MCPH1, SLC52A2, ITGB5, ITPR3, POGLUT2, KIF22, LAMC2, LMX1A, ETNPPL, MARCKS, MXD1, HHIP, MEN1, MMP2, MMP16, MRC1, MS, NR1H4, PROK2, LGR6, PPP1R9A, KLK15, TRPV6, BFAR, HSPA14, PPP3CB, PRKAR1A, MAPK3, PRNP, PDE11A, DHH, ITSN2, PRS, PSD, PSPH, OBP2A, PTGS1, RAC1, RAP1A, RAPSN, RBM3, REM1, IGKV2D-28, REG1A, RABGEF1, PPARG, POU3F1, OAS3, NRN1, CHDH, OPRM1, OXTR, PACC1, RCBTB1, TUG1, CASZ1, BIVM, REG3A, PDE2A, TERF2IP, CNTN5, PTOV1, SERPINF1, PENK, CFP, PIK3CA, CINP, PLXNA2, POR, SNX7, ABO
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Todd's Paresis
Wikipedia
Todd's paresis Other names Todd's paralysis , or Todd's palsy Specialty Neurology Todd's paresis (or postictal paresis/paralysis , "after seizure") is focal weakness in a part or all of the body after a seizure . This weakness typically affects appendages and is localized to either the left or right side of the body. It usually subsides completely within 48 hours. Todd's paresis may also affect speech , eye position (gaze), or vision . The condition is named after Robert Bentley Todd (1809–1860), an Irish-born London physiologist who first described the phenomenon in 1849. [1] [2] It may occur in up to 13% of seizure cases. [3] It is most common after a focal motor seizure affecting one limb or one side of the body. [4] The generally postulated cause is the exhaustion of the primary motor cortex , although no conclusive evidence is available to support this. Contents 1 Presentation 2 Causes 3 Diagnosis 4 Treatment 5 Prognosis 6 References 7 External links Presentation [ edit ] Robert Bentley Todd The classic presentation of Todd's paresis is a transient weakness of a hand, arm, or leg after focal seizure activity within that limb.
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Penile Fracture
Wikipedia
Non-surgical approaches result in 10–50% complication rates including erectile dysfunction , permanent penile curvature , damage to the urethra and pain during sexual intercourse , while operatively treated patients experience an 11% complication rate. [4] [12] In some cases, retrograde urethrogram may be performed to rule out concurrent urethral injury. [12] Legal issues [ edit ] In the United States , the case of Doe v. Moe , 63 Mass. App. Ct. 516, 827 N.E.2d 240 (2005), tested liability for a penile fracture injury caused during sexual intercourse.
- Leucism Wikipedia
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Myelopathy
Wikipedia
Myelopathy Specialty Neurology Myelopathy describes any neurologic deficit related to the spinal cord . [1] When due to trauma , it is known as (acute) spinal cord injury . When inflammatory, it is known as myelitis . Disease that is vascular in nature is known as vascular myelopathy . The most common form of myelopathy in humans, cervical spondylotic myelopathy (CSM) , [2] [3] is caused by arthritic changes ( spondylosis ) of the cervical spine , which result in narrowing of the spinal canal ( spinal stenosis ) ultimately causing compression of the spinal cord. [4] In Asian populations, spinal cord compression often occurs due to a different, inflammatory process affecting the posterior longitudinal ligament . Contents 1 Presentation 2 Diagnosis 2.1 Diagnosis of myelopathy 2.2 Diagnosis of etiology 3 Treatment 4 See also 5 References 6 External links Presentation [ edit ] Clinical signs and symptoms depend on which spinal cord level (cervical, [5] thoracic, or lumbar) is affected and the extent (anterior, posterior, or lateral) of the pathology, and may include: Upper motor neuron signs —weakness, spasticity, clumsiness, altered tonus, hyperreflexia and pathological reflexes, including Hoffmann's sign and inverted plantar reflex (positive Babinski sign) Lower motor neuron signs—weakness, clumsiness in the muscle group innervated at the level of spinal cord compromise, muscle atrophy, hyporeflexia, muscle hypotonicity or flaccidity, fasciculations Sensory deficits Bowel/bladder symptoms and sexual dysfunction Diagnosis [ edit ] Diagnosis of myelopathy [ edit ] Myelopathy is primarily diagnosed by clinical exam findings. Because the term myelopathy describes a clinical syndrome that can be caused by many pathologies the differential diagnosis of myelopathy is extensive. [6] In some cases the onset of myelopathy is rapid, in others, such as CSM, the course may be insidious with symptoms developing slowly over a period of months.MTHFR, ADA, APP, NAXE, GNPTAB, DKK1, THBS1, ATF7IP, TNF, LAMC2, CSF2, IL15, IL6, MBP, IL2, VDR, HLA-DRB1, GC, HLA-C, PTPN13, AMN, SERPINH1, APOE, H3P13, RAB4A, REG1A, PWAR1, RNPEP, SPP1, NRSN1, TAC1, TACR1, CNTN2, TMTC1, SMUG1, FOXP3, TP53, TTR, DPYSL5, IL18RAP, NR1I2, TMED2, CHDH, PTGS2, TPPP, CHP1, IL23A, SLC52A2, LTA, TNFRSF11B, BTD, F2R, CDKN2D, CDKN2A, CD38, CD9, CD6, BMP4, GHRH, BDNF, BCR, SLC25A6, SLC25A4, ABCD1, AHSG, F9, HIF1A, NGF, IL17A, MS, MMP9, ADM, LEP, KIR3DL2, KIR2DS1, IL10, HLA-G, CXCL8, IL2RB, IFNG, IFNB1, HRES1, HPRT1, H3P19