Human Papillomavirus Type 18 Integration Site 1

In 2 cervical carcinoma cell lines, HeLa and C4-I, Durst et al. (1987) found that HPV18 DNA was integrated into chromosome 8, 5-prime to the MYC gene (190080). See also Couturier et al. (1991). Thus, cis-activation of cellular oncogenes seems to be responsible for malignant transformation of cervical epithelial cells in some cervical cancers.