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Infantile Liver Failure Syndrome 2 OMIM

A number sign (#) is used with this entry because of evidence that infantile liver failure syndrome-2 (ILFS2) is caused by homozygous or compound heterozygous mutation in the NBAS gene (608025) on chromosome 2p24. ... Clinical Features In 10 unrelated families, most apparently of European descent, Haack et al. (2015) identified 11 patients, aged 3 to 37 years, with onset of recurrent acute liver failure in infancy. ... Molecular Genetics In 5 unrelated German patients with ILFS2, Haack et al. (2015) identified homozygous or compound heterozygous mutations in the NBAS gene (see, e.g., 608025.0002-608025.0006). The mutations, which were found by whole-exome sequencing, segregated with the disorder in the families with available data. Screening of the NBAS gene in 15 additional unrelated patients with acute liver failure identified biallelic NBAS mutations in 6 patients from 5 families. ... Patient fibroblasts showed a reduction of NBAS levels to 18 to 36% of control values, indicating a substantial impairment of protein translation and/or stability.

NBAS, MARS1
- Fever-Associated Acute Infantile Liver Failure Syndrome Orphanet
  
  A rare genetic parenchymatous liver disease characterized by infantile or early childhood onset of recurrent episodes of acute liver failure precipitated by a febrile illness. During the life-threatening episodes, patients present with vomiting, lethargy, jaundice, as well as elevated levels of liver enzymes and coagulopathy. There is usually complete recovery between the episodes with conservative treatment.
Short Stature, Optic Nerve Atrophy, And Pelger-Huet Anomaly OMIM

A number sign (#) is used with this entry because of evidence that short stature, optic nerve atrophy, and Pelger-Huet anomaly (SOPH syndrome) is caused by homozygous mutation in the NBAS gene (608025) on chromosome 2p24. ... Molecular Genetics In 33 Yakut patients from 30 families with short stature, optic nerve atrophy, and Pelger-Huet anomaly (SOPH syndrome) mapping to chromosome 2p24.3, Maksimova et al. (2010) analyzed 2 candidate genes and identified homozygosity for a missense mutation in the NBAS gene (R1914H; 608025.0001) that segregated with disease. ... INHERITANCE - Autosomal recessive GROWTH Height - Postnatal growth failure HEAD & NECK Head - Brachycephaly Face - Long face - Senile-appearing face - Narrow forehead - Prominent glabella - Hypoplastic cheekbones - Small facial features - Facial asymmetry - Long philtrum Eyes - Thick eyebrows - Bushy eyebrows - Small orbits - Exophthalmos, bilateral - Epicanthus - Optic nerve atrophy, bilateral - Decreased visual acuity, nonprogressive - Achromatopsia, complete or incomplete - Myopia (in some patients) - Strabismus (in some patients) - Hypertelorism (in some patients) - Hypermetropia (rare) - Pigmented nevus (rare) Nose - Straight nose Mouth - Thin lips Neck - Short neck GENITOURINARY Internal Genitalia (Female) - Uterine hypoplasia (in some patients) SKELETAL - Delayed bone age (in some patients) Skull - Brachycephaly - Hypoplasia of frontal tubers - Hypoplasia of parietal tubers Limbs - Micromelia Hands - Brachydactyly - Hypermobility of small joints - Simian crease (in some patients) - Syndactyly (rare) Feet - Brachydactyly - Hypermobility of small joints - Wide feet - High arch - Sandal gap - Wide hallux SKIN, NAILS, & HAIR Skin - Loose skin - Decreased turgor of skin Hair - Fine hair MUSCLE, SOFT TISSUES - Muscular hypotonia NEUROLOGIC Central Nervous System - Normal intellectual function VOICE - High voice with harsh timber HEMATOLOGY - Hypolobulation of granulocyte nuclei (Pelger-Huet anomaly) MOLECULAR BASIS - Caused by mutation in the neuroblastoma-amplified sequence gene (NBAS, 608025.0001 ) ▲ Close

NBAS
- Short Stature-Optic Atrophy-Pelger-Huët Anomaly Syndrome Orphanet
  
  Radiographs may evidence delayed bone age, late ossification and/or osteoporosis.
Acrofrontofacionasal Dysostosis Wikipedia

An association with mutations in the neuroblastoma amplified sequence gene ( NBAS ) has been reported. [2] This gene is located on the short arm of chromosome 2.

NBAS
- Acrofrontofacionasal Dysostosis Orphanet
  
  A rare congenital malformation syndrome characterized by the association of facial and skeletal anomalies with severe intellectual deficit and occasional genitourinary anomalies. Epidemiology Only 12 patients have been reported since the first description in 1985, 7 originate from Brazil. Clinical description The cranio-facial malformations are numerous and variable. They include brachycephaly or microbrachycephaly, prominent forehead with low frontal and occipital hairline, wide anterior fontanel, hypertelorism, large philtrum, broad notched nasal tip, cleft lip, highly-arched palate, small ears with prominent helix, hypoplasia of mid-face, and prognathism. Other skeletal malformations are also present, with syndactyly of fingers 3 and 4, hypoplastic 3rd, 4th and 5th toes, anomalies of feet structure and fibular hypoplasia.
- Acrofrontofacionasal Dysostosis 1 OMIM
  
  Richieri-Costa et al. (1992) reported another Brazilian family in which a woman had characteristic features; her similarly affected brother died at age 1 year. Guion-Almeida and Richieri-Costa (2003) reported a third Brazilian family with acrofrontofacionasal dysostosis in a brother and sister born of second-cousin parents. ... X-rays revealed hypomineralization of the calvaria, large anterior fontanel, dislocation of hips, short long bones, brachymetacarpia, hypoplastic distal phalanges, polysyndactyly (an extra digit between digits 3 and 4), and hypoplastic fibulae. Examination at 11 years of age showed global microsomia, with height, weight, and head circumference all below the third percentile.
Delayed Milestone Wikipedia

Delayed milestone Other names Developmental delays Specialty Pediatrics Delayed milestone , also called developmental delays , is used to describe the condition where a child does not reach one of these stages at the expected age. However, in most cases, a wide variety of ages can be considered normal, and not a cause for medical concern.

NBAS, PIGQ, SLC2A1, SZT2, COL4A1, IGF1R, RAC1, GNB1, TCF20, GLRA1, KDM5C, GABRA5, GABRA2, KDM1A, TRIT1, TRAPPC12, STT3B, ZNF335, VPS53, STT3A, TAOK1, TKFC, DDC, DIAPH1, PNPT1, ALKBH8, TBC1D20, ABAT, AP4S1, ACTL6A, SLC5A6, CACNA2D2, UBTF, PIBF1, DEGS1, SPTBN2, SPART, CDKL5, MECP2, PTEN, DPH1, PUF60, UBE3A, EMC1, PTPN11, GRIN2B, FMR1, AP4M1, SCN3A, SHOC2, NUP214, HTC2, TSHR, COX3, WDR37, MTFMT, NCOR1, CEP128, SNHG14, EMC1-AS1, ASXL1, BBS4, BRAF, NRXN1, KCNJ11, FOXG1, NAA10, YWHAE, TRNT1, PAFAH1B1, SOX5, PLP1, STXBP1, WDR45, ARSD, NSD1, CACNA1A, SLC13A5, SH2B1, AUTS2, NALCN, ANKRD11, TWIST1, PAX6, MEF2C, NSD2, ARX, CHD8, DYRK1A, DMD, GABRB3, SIM1, KAT6A, MBD5, ACTB, KIF1B, IQSEC2, STAG2, MAPT, PMP22, TENM3, KIF1A, FGFR3, LRP5, LIG4, FRAXE, USP9X, KCNQ2, SMC1A, TCF4, RUNX1, ARID1B, PNP, BDNF, MAGEL2, WWOX, PDP1, PNKP, UROD, GABARAP, FOXP2, QRICH1, FBN2, NGF, EBF3, PIGH, SIRT6, NDN, BRCA2, TARDBP, TASP1, TUBB2A, DRD3, PPM1D, CDC42, FRAXA, AGO1, HNRNPU, CDKN2A, CHRNA7, SATB2, ASXL3, EXOC6B, CMIP, ZBTB20, SHANK3, SETBP1, MED13L, DOCK3, HRAS, FOXP1, SCN8A, IL6, PCDH19, KAT6B, GNAO1, CTNNB1, CNTN6, SOX3, SLC16A2, ZNF462, SLC4A4, HAX1, IFNG, TUBB3, RSS, MLYCD, DICER1, RHOQ, RNF13, CAMTA1, RTL1, PPP1R13B, ERCC6L2, POGZ, FBXO28, UBE3B, IRGM, KANK1, GADL1, KDM6B, UNC80, ELOF1, MARS2, BHLHA9, CDK2AP2, GPHN, BCAP31, TWIST2, FRY, EDIL3, DNM1L, ABCB6, SH2B3, PPP1R21, SCO2, AMMECR1, KIF14, MTCO2P12, MFN2, H3P8, SV2A, KEAP1, NLRP5, HDAC4, KMT2B, HDAC9, GREB1, BAIAP2, SYNCRIP, SUPT16H, STK25, CADPS2, ADAMTS6, CCDC103, KPTN, CAPN10, RPP14, PAXBP1, CKAP4, SUB1, PAPOLA, TUBGCP2, HBS1L, KDM5B, RAI1, RAI2, IYD, NRG3, EBP, POMT1, MIR484, AZIN2, ARFGEF2, TUBGCP5, C12orf57, VCX, HEY2, AS3MT, VPS13B, LRRC4C, CAPS2, KIF17, PIGO, HECW2, NLN, SLC12A5, PARP10, TBC1D24, ZMIZ1, KISS1R, SALL4, RARS2, RETN, DNAJC12, SMG9, ZC4H2, KMT2E, ASH1L, VPS11, NGLY1, NKAIN2, CIAO3, NLRP2, ALG9, TRAF7, DSG4, ZRANB3, LRMDA, TRAPPC9, SNX27, OPA3, NAA15, PGAP1, NRSN2, GPBAR1, CNTN4, SLC25A22, TBL1XR1, DERL1, FTO, PRRG4, ALG8, PCDH15, UPF3B, NBEAL1, CSMD1, PACS1, AGO3, MACF1, SGMS1, NTM, SMARCAL1, SETD2, MRPS28, LAMTOR2, DLL1, PGAP2, HPGDS, AHDC1, DISC1, ZBED3, UBL7, SACS, FBXL4, PHGDH, FBXL3, ASPM, NIPBL, RAB3GAP2, GSPT2, LEMD3, MMD, TANGO2, RALGAPA1, SLC35C1, UGT1A1, CWF19L1, ARID2, ATAD3A, THG1L, ADPRS, RAB36, AHI1, APOBEC3F, PPP1R12C, RBFOX1, NANS, CRBN, CACUL1, BCL11A, KDM3B, ATP8A2, WDR73, UPB1, SF3B6, ACTL6B, PHF21A, CEND1, BCOR, USP7, MAD2L1BP, GNB2, ITGB2, ISG20, INSR, CXCL8, IL2RA, IL1B, IGF1, IFN1@, NDST1, HSPA4, HOXB@, HOXA13, HNRNPH2, HIVEP2, NRG1, HDAC2, GRM7, GRIN2D, GRIN2A, GRIN1, GRIK4, GRIK3, GRIK2, GRID2, GPD2, GP1BB, GOLGA4, KCNB1, KCNC1, KCNH1, MID1, NHS, NFIA, NF1, NDUFA1, NBN, MUC1, MTHFR, COX2, MN1, ALDH6A1, MLLT3, KMT2A, MEIS2, KCNJ3, MC4R, MC1R, MBP, MAOB, MAOA, MAG, TACSTD2, KRT10, KIF11, KCNQ3, KCNQ1, KCNJ6, GOLGA2, GMDS, NTF3, GLS, CUX1, CTSL, CTBP1, CSNK2B, CRY2, CRX, CP, COL4A6, CNTF, CLTC, CLCN7, CLCN3, CENPE, CDKN1B, CD44, CD38, CD28, CA2, BTD, ADGRB3, AVP, ATRX, APOE, ALDH1A3, ABCD1, AKT1, ADSL, CYP21A2, CYP27A1, DHCR7, FANCD2, GLRB, GLI3, GHRH, GH1, LRRC32, FUT4, NR5A1, FOLH1, AFF2, FOXC1, BPTF, ACSL4, FABP3, CYB5R3, EYA1, EXTL3, EXT2, ESRRG, EPRS1, EPHA7, EFNB1, TOR1A, ATN1, ARID3A, DPYD, DNM1, CNOT2, NTRK2, MAGED1, SON, TUBA1A, MOGS, ZNF148, ZIC1, XIST, WNT1, WARS1, VWF, TRPV1, VEGFA, UVRAG, SLC35A2, UBE2A, TRPS1, TP53, NKX2-1, TGFBR2, NR2F1, TCOF1, TCF12, TBX1, ABCC8, SPOCK1, SPARC, SOX12, SOX9, SOX4, ALDH5A1, SEM1, TUSC3, SGCE, ATG5, EIF2AK3, NRXN2, EFTUD2, COPS2, DLGAP2, SLC6A5, CBFA2T2, DNAJA3, PAPSS1, MBD2, HERC2, EIF2B2, PDHX, ARHGEF7, CDK5R1, BANF1, TNFSF13, RIPK1, ABCB11, TP63, KLF7, CASK, CUL4B, PNPLA4, KMT2D, SOX2, SMS, OCRL, SMARCD1, MAP2K2, PPP3CA, PPP2CA, POU3F2, POMC, POLR2A, SEPTIN5, PMM2, PITX2, PIK3R2, PIK3R1, PIK3CG, PIK3CD, PIK3CB, PIK3CA, PIGA, PEPD, PDE1C, PAX2, PARN, PAK1, SERPINE1, OTX2, OTC, OPHN1, OPCML, ODC1, PRL, PRPS1, PSEN1, SCN1A, SMARCC2, SNAI2, SLC6A7, SLC1A4, SKP1, SHOX, SETMAR, SDHD, CXCL6, CCL11, CCL2, SCN7A, ATXN2, PTCH1, MSMO1, S100A9, RYR2, RPE65, BRD2, RALA, RAF1, RAD9A, QARS1, PVALB, PTGS2, PTH, H3P10
Infantile Liver Failure Syndrome 1 OMIM

Genetic Heterogeneity of Infantile Liver Failure Syndrome See also ILFS2 (616483), caused by mutation in the NBAS gene (608025) on chromosome 2p24. ... The patients showed signs of intermittent improvement and developed acute symptoms only when their bodies were under physiologic stress due to illness. Earliest age at presentation was 2 months; the oldest affected family member was 33 years old at the time of the report.

LARS1
- Acute Infantile Liver Failure-Multisystemic Involvement Syndrome Orphanet
  
  A rare, genetic, parenchymal hepatic disease characterized by acute liver failure, that occurs in the first year of life, which manifests with failure to thrive, hypotonia, moderate global developmental delay, seizures, abnormal liver function tests, microcytic anemia and elevated serum lactate. Other associated features include hepatosteatosis and fibrosis, abnormal brain morphology, and renal tubulopathy. Minor illness exacerbates deterioration of liver failure.
Hereditary Diffuse Gastric Cancer Orphanet

Hereditary diffuse gastric cancer is a rare epithelial tumor of the stomach, characterized by the development of diffuse (signet ring cell) gastric cancer at a young age, associated with germline heterozygous mutations of CDH1 , MAP3K6 and CTNNA1 genes.

CDH1, IL1RN, KRAS, TP53, CTNNA1, MUTYH, APC, MAP3K6, MYC, EGFR, CHEK2, TFAP2C, TWIST1, UMPS, TYMS, STAT3, TBX3, TGFA, TPM3, XRCC3, TNF, TIMP3, THBD, XRCC1, ACTC1, ZNF177, PLPP1, SELENBP1, FCGBP, SUCLG1, TNFSF9, IRS2, AKR1C3, CST7, SREBF2, ITGA8, BAP1, ARID1A, MIA, SYMPK, TAF15, PSCA, SOD2, SPRR2A, RARB, PTPRG, PTPRF, PTGS2, KLK10, PRNP, MAPK8, MAPK3, MAPK1, PRKCB, PRKAB1, PRKAA1, PREP, PTPA, PPP2R1A, PPIC, RAD23A, RARRES1, RRP9, RBP1, SNRPB, SNAI1, SLC1A2, RXRB, RPS26, RPS21, RPS19, RPS15, RPS6, RPL18, RPL15, RPL13, RORA, RGS2, RBP4, SLC16A3, WDR46, AURKB, PUS1, FAT4, FSD1, MRPS11, HRH4, KMT2C, RANBP10, EXOSC5, GKN1, CHFR, NAXD, RNF43, XAF1, KRT20, PTOV1, WWOX, EPHX3, ULBP2, NBAS, URM1, ZNF667-AS1, HOTAIR, PRR5-ARHGAP8, ATP6V0D2, DCBLD2, MBD3L2, LRRC3B, ZNF160, MIR22HG, TUBA1C, SPZ1, KISS1R, ZNF559, ARFGAP2, REG4, POLR3K, HIKESHI, IL32, PRDX5, FAM168A, WIF1, CCT7, ARL6IP5, NOP56, FST, DLC1, CNPY2, MSLN, EBI3, TRAP1, SCRN1, MTSS1, TMEM63A, PLIN2, BOP1, SERBP1, GMPR2, ZBTB20, PLCE1, ZNF593, UBXN1, COPS7A, ZNRD1, CPSF1, ABT1, PYCARD, MRPL13, MRPS18B, PRPF19, FILIP1, SNX5, ACAD8, GREM1, PPIA, PPARG, PLAU, FGG, DDB1, ACE, CYP2A6, CTSL, CTNNA2, CST1, CLDN3, KLF6, CLN3, CLCN3, CKB, CTSC, CDKN2D, CDKN2A, CDKN1B, GADD45A, DES, DNMT1, EEF1A2, FBP1, F2R, ERCC2, PLAGL1, ERBB2, ENO1, EEF1A1, DNMT3B, ECM1, ECHS1, TYMP, HBEGF, DPYD, DPAGT1, CDKN1A, CDK4, CDH2, ALDOB, APOA1, BIRC5, BIRC2, APEX1, ANXA5, ALOX5, ALDH1A3, RHOA, ALB, AHR, AGTR2, AFP, ADRB2, ADRB1, AREG, ATM, CD44, BNIP3, RUNX3, CAV1, CASP10, CASP8, CA2, CA1, BMP7, ALDH7A1, BMP2, BLVRB, BID, BDNF, BCL2L1, CCND1, FGFR2, ERCC1, FHIT, KISS1, MUC1, MTHFR, MT2A, MSX1, MMP10, MMP7, KMT2A, MLF1, MET, MARK1, SMAD4, M6PR, FADS1, FKBP2, LGALS3, MUC6, MX1, NDUFA2, SERPINB2, PIK3CA, SERPINA1, PHB, PGAM1, PDHA1, PAX6, SERPINE1, NDUFS1, PA2G4, NT5E, NPM1, NOTCH2, NOS3, NDUFV1, KRT8, CCAT1, HOXA2, HNRNPL, ICAM2, HSPD1, ID4, IDH3B, IGFBP3, HSPB1, HSPA8, IGFBP7, IL1B, IL6, HRAS, IL6R, HTR1A, CXCL8, HMOX1, GSTP1, TNFRSF9, ING1, IRF1, GLI3, ITGA5, FYN, JUN, GAST, REG1A, MLH1, MRC1, DSG2, FZR1, PALB2, CTNNB1, DSG1, DNAJB4, ST8, MRE11, BRCA1, BRCA2, CTNND1, MIR21, TGFBR2, TFF2, JUP, CDX2
- Hereditary Diffuse Gastric Cancer Wikipedia
  
  An estimated 70% of males and 56% of females who inherit an inactivating CDH1 mutation will develop this form of cancer by age 80. Female patients are also estimated to have a 42% lifetime risk of developing lobular breast cancer. [3] The median age of gastric cancer diagnosis in individuals with a CDH1 inactivating mutation is 38 years of age, but cases have been reported as young as 14 years of age. [4] Contents 1 Genetics 1.1 Non-CDH1 Forms 2 Treatment 3 Epidemiology 4 References Genetics [ edit ] HDGC is inherited in an autosomal dominant fashion. ... Any individual diagnosed with diffuse gastric cancer before 35 years of age from a low incidence population. ... No other gene has been proven to cause HDGC, but possible associated genes include CTNNA1 , BRCA2 , STK11 , SDHB , PRSS1 , ATM , MSR1 , and PALB2 . [5] Treatment [ edit ] Surgical removal of the stomach (gastrectomy) is typically recommended for people after 20 years of age, and before 40 years of age in order to prevent development of diffuse gastric adenocarcinoma. However, individuals discovering CDH1 mutations after the age of 40 may still be considered for gastrectomy. ... Due to the mild risk that may be associated, individuals often receive screening colonoscopies at age 40, five years prior to the recommendation in the general population. [3] Epidemiology [ edit ] The median age at diagnosis is 38 years.
- Gastric Cancer, Hereditary Diffuse OMIM
  
  In 1 family, 25 members ranging in age from 14 years upwards had died over 30 years. ... However, 7 remaining cases did not meet the HDGC criteria: 3 women had sporadic bilateral lobular breast cancer before age 50; 3 came from families with 2 cases of DGC after age 50; and 1 had sporadic diffuse gastric cancer after age 40. ... The workshop recommended that CDH1 testing criteria should take into account first and second-degree relatives: (1) families with 2 or more patients with gastric cancer at any age, 1 confirmed diffuse gastric cancer; (2) individuals with DGC before the age of 40 and (3) families with diagnoses of both DGC and lobular breast cancer (LBC), 1 diagnosis before the age of 50. ... Annual mammography and breast MRI from the age of 35 years was recommended for women. ... Breast cancer surveillance with annual breast MRI starting at age 30 for women with a CDH1 mutation was recommended.
- Hereditary Diffuse Gastric Cancer GARD
  
  Cancers associated with HDGC generally occur at earlier ages than those seen in people who do not have a hereditary predisposition to cancer.
- Hereditary Diffuse Gastric Cancer MedlinePlus
  
  Frequently, HDGC-related cancers develop in individuals before the age of 50. Frequency Gastric cancer is the fourth most common form of cancer worldwide, affecting 900,000 people per year.
Stomach Cancer GARD

Stomach cancer , also called gastric cancer, is a form of cancer that occurs due to abnormal and uncontrolled cell growth in the stomach. Most people with early stomach cancer have no signs or symptoms of the condition. In advanced stages, symptoms may include indigestion; nausea and vomiting; difficulty swallowing; feeling full after eating small amounts of food; loss of appetite; vomiting blood; fatigue; and/or weight loss. Most cases of stomach cancer occur sporadically in people with little to no family history of the condition; however, approximately 10% of stomach cancers are considered "familial." Although the underlying cause of some familial cases is unknown, genetic changes (mutations) are identified in a subset of people affected by stomach cancer.

CDH1, PIK3CA, MET, FGFR2, ERBB2, APC, IRF1, KLF6, MUTYH, CASP10, ATM, IL1RN, KRAS, PRKAA1, IL1B, CHEK2, ZBTB20, GKN1, CDKN2A, PPARG, CHFR, CDKN1A, AFP, DNMT3B, DPYD, PTGS2, TYMS, CXCL8, TNF, IL6, XRCC1, MSH2, STAT3, DNMT1, SMAD4, EGFR, HOTAIR, ALB, SNAI1, ERBB3, MYC, MUC1, MTHFR, MAPK3, GAST, SERPINE1, MAPK1, TP53, PSCA, CAV1, RUNX3, TWIST1, FHIT, MMP7, XRCC3, PLCE1, ERCC1, ERCC2, GSTP1, ARID1A, CCND1, CD44, MLH1, REG4, RHOA, APEX1, KRT20, BRAF, PLAU, TIMP3, CASP8, IGFBP3, LGALS3, KLK10, PRKAB1, PRNP, ENO1, CCAT1, ACE, FAT4, CDKN1B, CDK4, HMOX1, ZNRD1, IL32, AHR, SOD2, KMT2C, NOTCH2, AREG, MT2A, NPM1, XAF1, AURKB, BMP2, ARL6IP5, JUN, MAPK8, TGFA, HRAS, ADRB2, DLC1, MUC6, PTPA, ITGA5, MTSS1, F2R, HSPB1, PHB, FSD1, IGFBP7, TYMP, FBP1, PYCARD, SERPINB2, KISS1, WWOX, PRKCB, KMT2A, PAX6, BDNF, BCL2L1, RNF43, UMPS, BIRC5, MSLN, RORA, UBR5, WIF1, SCRN1, MIA, PDHA1, NOS3, ECM1, ATR, ING1, CLCN3, RARRES1, SLC1A2, LRRC3B, CST1, DCBLD2, POLE, EEF1A2, SPZ1, MIR22HG, PLAGL1, TNFRSF9, ECHS1, KISS1R, NBAS, HBEGF, HSPA8, AXIN2, CLDN3, BAP1, NT5E, ICAM2, HSPD1, PRDX5, PPIA, RGS2, SLC16A3, RARB, AKR1C3, GLI3, TBX3, FGG, RPS6, SERPINA1, CKB, KRT8, ANXA5, THBD, ALOX5, COPS7A, PTPRG, HIKESHI, MMP10, EBI3, BNIP3, MSX1, MLF1, FADS1, BID, FAM168A, RBP1, IL6R, NOP56, RPS15, ZNF667-AS1, M6PR, SNX5, ADRB1, MRPS18B, MRPL13, CLN3, SREBF2, HRH4, FST, RPL15, ATP6V0D2, SUCLG1, ZNF177, ALDH7A1, RBP4, NAXD, RXRB, EPHX3, CTSC, ZNF593, FILIP1, UBXN1, CDKN2D, RPL13, SPRR2A, AGTR2, RRP9, CCT7, EXOSC5, HNRNPL, IRS2, MARK1, CTNNA2, CST7, CTSL, RPS21, DES, ACAD8, RAD23A, CYP2A6, RANBP10, GADD45A, HOXA2, DDB1, PLPP1, ABT1, DPAGT1, ITGA8, BOP1, ID4, MRPS11, TRAP1, TNFSF9, PGAM1, RPS26, EEF1A1, IDH3B, ALDH1A3, RPS19, HTR1A, NDUFA2, APOA1, NDUFS1, ALDOB, BIRC2, NDUFV1, CDH2, CPSF1, RPL18, SNRPB, PPP2R1A, WDR46, TFAP2C, PA2G4, PREP, SYMPK, FKBP2, TUBA1C, POLR3K, ARFGAP2, PTPRT, PTOV1, CA2, FCGBP, TMEM63A, BLVRB, ACTC1, PUS1, MBD3L2, CNPY2, TAF15, GMPR2, BMP7, PTPRF, PRR5-ARHGAP8, ZNF559, PLIN2, ULBP2, GREM1, PPIC, SELENBP1, SERBP1, FYN, PRPF19, MX1, URM1, ZNF160, CA1, TFF1, TPM3, IL6ST, ANXA1, REG1A, TXNIP, STK11, MSH3, BUB1B, BUB1, BUB3, PRKAR1A, BMPR1A, RPS20, MIR17, MIR141, KLF4, SIRT1, HMGA2, TIMM8A, MIR149, H3P10, LGR5, MIR148A, MIR146A, MIR155, ALDH2, MIR125A, E2F1, CYTOR, ABO, MIR145, MIR126, MTCO2P12, ABCB1, PVT1, MTOR, DNMT3A, CD274, MIR143, SEMA4A, IL17F, MTDH, PTP4A3, NME1, MIR107, HPSE, EPHB2, SMR3B, PTPN11, MGMT, REM1, OGG1, MMP1, ERCC4, HPGDS, ERCC5, GLI1, ESR1, GSTM1, CXCR4, SPP1, TLR4, EZH2, NEAT1, TLR2, SPARC, MMP14, PCNA, ZEB2, SOX9, MACC1, NFKB1, MMP2, HMGB1, MIR106A, PGC, TRIP13, TIMP1, MDM2, FOXO1, EGF, AKT1, FOXM1, SLCO6A1, HIF1A, HGF, NOTCH1, ELAVL2, MMP9, JAG1, HDAC1, SOX2, MALAT1, GSTK1, TBC1D9, PDCD4, GSTT1, RASSF1, MIR34A, CDH17, TGFB1, YAP1, MIR375, MEG3, PTEN, MIR223, FBXW7, TFF3, IGF1R, PSG2, HSP90AA1, THBS1, NAT2, MIR214, TFF2, CXCL12, MIR25, S100A4, MIR27A, IFNG, CEACAM3, MIR335, MIR338, FOXP3, SFRP1, IGF1, CEACAM5, CDX2, MIR29A, IL10, IL11, SMAD2, MIR27B, IL17A, IL1A, MUC5AC, CEACAM7, S100A8, BRCA1, AURKA, PKM, ZEB1, VEGFC, VEGFA, MIR195, CYP2E1, CEP57, PIK3CG, PIK3CD, UCA1, COX2, PIK3CB, MIR421, VIM, KDR, SGCB, CASP3, WNT5A, BCL2, CLDN18, TERT, MIR21, ABCC1, CCK, OLFM4, PROM1, MIR204, BMI1, JAK2, MIR203A, CTNNB1, MIR200C, LILRB1, ERBB4, PARP1, FZD7, ADH1B, FGFR1, CD14, LEP, PEBP1, CD34, CYP1A1, MIR200B, FAS, MIR10B, MIR22, MIR144, MIR206, CREB1, AICDA, PLK1, MIR221, ACKR3, MIR29C, MIR222, MRC1, DCC, HNF4A, PPP1R1B, AFAP1-AS1, EPCAM, CD24, POU5F1P4, TP73, MCL1, ADAM17, CEACAM6, FGF2, TOB1, POSTN, MYCL, GKN2, MIR122, BRCA2, POU5F1, ANXA2, MIR152, HSPA5, HOXA10, IL4, COMMD3-BMI1, POU5F1P3, MECP2, GDF15, GSTM2, HLA-A, ZFAS1, MIR140, MIR19A, MBD2, MIR20A, PRKAA2, TMED7-TICAM2, MIR494, CCKBR, MUC2, TICAM2, MIR495, FOXO3, CD163, RUNX1, LDHA, MIR497, LGALS1, H3P23, STMN1, FSCN1, CIP2A, MUC16, GAS5, MIR183, MIR451A, CCL2, HSPA4, MIR23B, MIR93, SOCS3, MIR31, ZNRD2, PSMD9, EGR1, LTA, SLC12A9, TMED7, IFI27, LRPPRC, LOX, GSK3B, DAPK1, ABCG2, FGFR4, SP1, DCTN6, AR, MIR130A, CXCL1, TNFAIP8L2, SETD2, ANGPTL2, EIF5A2, IGF2, NFE2L2, SMAD7, IL22, MSH6, NOD2, KDM1A, GATA6, NM, MAP1LC3B, SOCS1, NCL, ITGB1, NRP1, TET1, HSPB3, BECN1, MDK, SATB1, MMP11, CDK6, MIR34B, TIMP2, NDRG1, NOD1, ZEB1-AS1, CCNB1, MIR217, MIR212, CTLA4, TGFBR2, MIR196A2, ARHGDIB, MIR508, PAK4, MIR185, MIR182, CDKN2B-AS1, MIR675, BAX, EIF4E, EPHA2, RAF1, MIR137, BSG, MIR30C2, MIR106B, MIR340, MIR370, VAV3, CDKN2B, MIR17HG, MIR302B, MIR361, CD82, SPHK1, CXCR1, HPGD, MIR192, MIR196B, HOXA13, SQSTM1, DLL4, IQGAP1, CDX1, XPO1, CCR7, MIR181A2, PRDX2, SKP2, CDK2, KLF5, TEAD4, MAP2K7, PRMT5, GDE1, IL2, S100B, CXCR2, CXCR6, DDIT3, PRKDC, MIR18A, PCDH10, CASR, MIR320A, MIR378A, CRKL, CRK, CLDN4, CD40, MIR423, CCN1, PRPF31, ICAM1, CHPT1, CD68, COL1A1, MIR30C1, METTL3, MIR32, MIR425, SALL4, KLF2, MIR135B, MIR148B, NEDD9, DANCR, CCN2, MIR205, MIR210, WNT1, CRP, MIR133B, RACK1, INHBA, RPSA, TP73-AS1, MIR23A, CCND2, CLIC1, PROX1, KLRC4-KLRK1, FLT1, DLEC1, MDM4, MIF, PDK1, IL23R, KLF8, PTPN1, ANXA7, FOXK1, NR1H2, MICA, RNF180, NOX4, FGF9, ARHGAP24, RELA, MAD2L1, DHDDS, UBE2C, S100A1, LMX1A, CT83, FRZB, MGR1, GHET1, GABPA, KLRK1, IL33, HOTTIP, FOXQ1, MIRLET7B, HAVCR2, SLC2A1, AGT, SULF1, NOS2, C17orf97, TLR5, RASAL1, MIR381, CCL5, MIR383, RAC1, MXI1, TES, CD36, ALDH1A1, AKT2, ADRA1A, MAP3K1, TPI1, H3P9, IL18, CDC42, MMP13, TSPAN8, CCAT2, ADH1C, PCAT1, NXT1, SPRY4-IT1, TRAF2, MCC, ADRA2B, LAPTM4B, DKK3, SNHG16, CD80, LAMC2, PTK2, MAP2K1, MIR506, ZFHX3, TGFB2, NET1, ATP4A, ATP4B, MT1JP, S100A6, VDR, TFAP4, BGN, UHRF1, MIR630, TERF2, CDK5, BRS3, KLK6, KRT19, L1CAM, LGMN, COX1, MIR532, TLR9, MIR708, MIR503, SMOX, SCO2, MIR363, CCNE1, MIR551B, THY1, HDAC6, MIR146B, THBS4, THBS2, PTCH1, FASLG, CHAF1A, LATS1, UGT1A1, CASC11, WEE1, MIR499A, MIR501, TACSTD2, TGFBR1, MSI1, ANGPT2, FSTL1, IL16, KLF12, USP22, MIRLET7C, COL18A1, ROBO1, SSTR4, DICER1, EDNRA, SIRT4, TKTL1, HMGB3, E2F3, WNK1, NR4A2, FOXA1, MIR132, SERPINB5, MIR139, NQO1, BRD4, GSPT1, FGF4, SUZ12, CXCR3, MYH9, STC2, VTCN1, YBX1, SUB1, GADD45G, ERCC6, KDM4B, BCL6B, FAP, MSC, FASN, MTA2, EPAS1, SST, SOX2-OT, ADIPOQ, SNHG5, IRX1, GPX3, SRPK1, GPR42, ZFX, COX5A, HFE, ROCK1, KHDRBS1, CPOX, FLT4, ROS1, TBPL1, SOAT1, FEZF1-AS1, COX8A, PLG, PDCD5, MIR29B1, MRPL28, SLC7A5, MIR224, FN1, MIR34C, ERCC8, SELE, CIB1, TNFRSF6B, CDKN3, GATA4, GAPDH, SOX4, TINCR, MAPK14, PAX3, LPAR2, DAB2IP, PITX1, HOXD10, HP, MIR198, MIR219A1, SEMA6A, FSD1L, HES1, PLA2G2A, MIR200A, HSPB2, VCAN, MIR215, MRE11, CLDN11, RAD51, ODC1, PIWIL1, PAEP, RBX1, PRKN, RNASE3, HDAC4, NID2, RDX, SOCS6, FERMT2, PTPN14, AKT3, PBX3, TDGF1P6, SIRT2, OPCML, PAK1, RAB1A, RPL23, MPO, PAX5, WASF2, STARD3, NBN, PIN1, AKR1A1, DAPK2, NUP62, NEK2, MTRR, SNHG1, MUC4, KDM4A, CADM1, AHSA1, PIM1, SLC34A2, POLDIP2, PMS2, CXCL13, PTENP1, RNF19A, LRIG1, PPARD, SPON2, POT1, MTR, CBX7, ABCB6, MST1R, RBP2, PSMD10, HDAC9, PDGFRB, AGO2, ACTR2, RBM4, KIF20A, MSMB, MST1, MSX2, ATG5, PFKFB3, CACYBP, TNK2, HSPH1, HTRA1, MTA1, GRAP2, SIRT3, PGK1, NTN1, GRB7, EIF4A3, SNHG12, YWHAZ, ESR2, ZKSCAN1, EREG, SRI, EPHB4, EPHB3, DLX6-AS1, TRIM59, SRF, CTTN, ZIC1, FEZF1, MIR454, BAK1, MIR187, STAT1, S1PR1, MIR128-2, DUSP4, STAT4, MIR129-2, YES1, MIR134, MIR136, MIR142, MIR150, XRCC5, MIR181C, ETS1, SNHG8, F2RL1, PCGF2, NKD2, MIR543, LMLN, XRCC6, SNCG, TP53INP1, NR5A2, FOSL1, FPR1, FOS, CTHRC1, ANIB1, CMTM3, TFPI2, AIMP2, MIR940, VEGFD, CBLL2, FGF7, SOX11, FGA, NLRP6, ATOH1, ATP12A, HOXA11-AS, MIR744, CASC2, MIR186, MIR188, MIR874, MIR20B, CDH13, MIR613, MIR372, CDC20, XIST, TERF1, CD151, MIR584, CD47, MIR4435-2HG, BST2, MIR449A, MIR362, WNT2, CYP19A1, TCF4, MIR490, MIR193B, MIR33B, CASP9, MIR181D, MIR505, CALR, MIR483, MIR455, EZR, RASSF10, CA9, TAC1, SYT1, MIR337, MIR331, TFAP2A, MIR193A, MIR196A1, CYP1A2, MIR197, MIR92B, MIR19B1, STC1, MIR216A, CRMP1, MAP3K8, MIR647, COL12A1, MIR638, SULT1E1, MIR29B2, COL6A3, MIR301A, MIR30A, MIR30B, COL1A2, STIM1, AURKC, CHRNA4, CHEK1, SULT2A1, XPC, SNHG20, VPS51, FNDC1, ITGB3, CASC9, TUG1, ADAM10, ISL1, IRF6, ANO1, ADAR, PDX1, INSR, ZNF654, INPPL1, TLR1, ILK, TRIM24, ENAH, ADM, HSP90B1, PBK, IKBKB, RPRM, TMPRSS4, ADAM9, TNFSF10, SRSF1, TNFSF13, ID1, TGFBI, PINX1, ITGB4, HTN3, LINC01410, GPRC5A, GIT1, ABL1, MBL2, MAL, RMC1, RPS27, SEMA5A, DELEC1, RRM2, TOP2A, GAL, S100A2, ANGPTL4, ING4, DCTN4, LGALS9, GOLM1, DACT1, ISYNA1, GACAT3, S100A11, RAB14, IL23A, KIF2A, TRPM7, ASPN, SMURF1, TRPC6, HTC2, FTO, HSP90AB1, HDAC2, RECK, MUL1, MIR1236, LIN28A, GTF2H1, ANGPT1, WLS, SLC16A1, FBXO11, CDK5RAP3, MIR1284, APRT, AQP3, GPER1, GPI, SNAI2, NCOA3, MLRL, SMARCA4, GLI2, GLDC, SESN2, TMPRSS13, NRG1, CUL4B, HNRNPA1, NDRG2, TP63, ANKRD36B, HOXB7, IL21, PRMT1, BHLHE40, GOLPH3, FRTS1, PIK3R3, GAPLINC, AGER, HMGB2, HSF1, HHIP, GORASP1, HLA-E, CEMIP, HLA-DQB1, GEMIN2, HLA-DQA1, LINC00673, TIAM1, HOXC10, UVRAG, KMT2B, TTK, UCHL1, STARD8, TXN, UTRN, TTR, USF1, TP53BP2, DIRAS3, SLC9A3R2, SEMA3E, ATG12, SPOP, ULK1, NR0B2, CUL4A, DCLK1, OGT, PPM1D, DENR, DYNLL1, SCAF11, FADD, PCLAF, TNFRSF10B, CCN6, CCN5, CCN4, HDAC3, NR1I2, FUBP1, MTMR3, F2RL3, DOK2, FZD1, AXIN1, VIP, ADAMTS1, VGLL4, WNT6, WNT7A, WNT10B, XDH, KLK4, XPA, CLOCK, XRCC2, XRCC4, YY1, PDLIM7, ZFP36, MZF1, CLDN1, PRDM2, BTG2, FZD5, KMT2D, YEATS4, CDR3, KDM5D, NAT1, PCDHB9, BMS1, MIRLET7E, LINC01194, CASC15, LIN28B, SNHG17, NANOGP8, VSIG1, TFAP2E, SNHG15, HOXA-AS2, ZFP82, LYPD5, HNF1A-AS1, H19, CTAG1A, MPEG1, MIRLET7D, MIRLET7I, TIGIT, MIR100, MIR324, MIR302C, MIAT, MIR99B, MIR95, MIR33A, MIR296, MIR28, MIR211, MIR199A2, MIR199A1, MIR154, MIR130B, MIR129-1, MIR127, NAIF1, MLKL, GSDMD, MFSD2A, HOPX, LOXL4, CCDC8, CDCA3, TCF7L1, NECTIN4, SETD7, ZFP91, CMIP, SRCIN1, SLC19A3, CD276, WNT10A, CXXC4, MUS81, GLIS2, SNHG7, RASSF6, SCIN, MAGEB6, BTLA, PDIK1L, MDP1, GSC, MUC17, CLDN23, LINC00628, ANTXR2, RAB3IP, FBXO32, SLC52A3, SAT2, ZFAND4, WNT3A, MIR326, MIR328, MIR367, MIR761, MIR1179, MIR1271, MIR1297, MIR1207, MIR1258, MIR1256, MIR1296, MIR1915, LINC00941, FAM83H-AS1, EGOT, MIR365B, MIR760, MIR885, MIR938, ZEB2-AS1, CBR3-AS1, MIR376C, LINC01234, H3P47, LOC110283621, CDR1-AS, TP53COR1, PRNCR1, BLACAT1, LSINCT5, PANDAR, LINC01939, TRERNA1, MIR5590, NNT-AS1, MIR4795, MIR4455, LINC00665, MIR873, MIR876, GGTLC4P, NBAT1, MIR486-1, MIR519D, MIR524, MIR202, MIR491, MIR409, MIR18B, MIR448, MIR429, MIR424, MIR379, MIR377, CISD2, MIR374A, MIR371A, SNHG6, PGA3, CRNDE, MIR598, HULC, GGT2, GGTLC3, LINC00460, MIR663A, MIR646, MIR593, MNX1-AS1, MIR585, MIR574, MIR542, MIR545, GGTLC5P, NORAD, GRHL2, FBXO31, MELK, TRIM29, SMUG1, NNT, SIRT5, SASH1, WWC1, EPB41L3, KDM6B, SPART, KDM2A, DKK1, RUFY3, ECD, RASSF8, GALNT5, ANXA10, CORO1C, TMEFF2, WDR5, TFIP11, MCTS1, DLL1, MCAT, RABGEF1, IL17B, PELP1, NOX1, EHF, FBXL5, RAI14, WWTR1, OLFML2B, LETMD1, BRMS1, TNFAIP8, CORO1A, ESM1, CLIP4, PDLIM5, NDC80, PIAS3, TUBB3, CLEC4M, STUB1, ABCC4, SPRY2, TRIM28, DNM1L, HDAC5, KCNE2, PTBP3, REC8, USP3, MFN2, MERTK, PDPN, TRIM31, IGF2BP3, CNMD, WWP1, STIP1, ERP29, BTG3, RALBP1, MMP24, TSPAN9, PPP1R13L, WASF3, IQGAP2, KDM5B, USP39, CD226, SPINT2, RACGAP1, DNMT3L, ERO1A, RPRD1B, CCAR2, SYT13, SCYL1, S100A14, ERGIC1, VANGL2, PAK5, CD248, TIGAR, CIAPIN1, AKR1B10, ADAMTS9, TM9SF3, SULF2, GSDMB, HAMP, PRDM16, TBX21, PCGEM1, TBL1XR1, PAGR1, FA2H, MMP28, GGCT, MARCKSL1, NDRG4, CENPH, SMYD3, COP1, SOX17, NOC3L, POPDC3, VSIR, PBLD, IL26, PRR11, URGCP, ITLN1, SIRT7, DTL, FZR1, TNFRSF12A, LEF1, EGFL7, LINC00328, TRIM17, ADIPOR1, NDUFA13, APIP, TRAT1, IL21R, STOML2, ADGRE2, SIRT6, LARP7, MED15, AGGF1, VEZT, SAGE1, TRPV6, ZNF331, PHF10, IMP3, ATG16L1, RAB23, GID8, TENT5C, SYTL2, UGT1A7, DDIT4, PRR13, TNFRSF1A, CCNB2, PCDH7, CTAG1B, CSF2, CRYZ, CRYAB, CREBBP, CRAT, PLXNA1, PODXL, POLB, POMC, PON1, COL4A1, CCR6, CCR4, CMA1, POU5F1B, CLU, CKS2, PPBP, PPP1R1A, PRKCI, CETN1, CST4, CTBP1, SIAH1, CTSK, DPYSL3, DPT, DOK1, REG3A, TRDMT1, PCBP1, DYNC1I1, GSDME, DECR1, DDX6, DDX5, PCDH8, DCN, BRINP1, DAP, PDCD1, PDGFRA, CYP2C19, CYLD, CYBB, CUX1, CDO1, CDKN1C, PSD, PSEN1, RET, RNASE1, RNF2, BMX, RPL6, BDKRB2, BCL9, RPS15A, BCL6, RTKN, S100A10, BAG1, SAT1, BAAT, AXL, CCL22, CXCL5, ASCL2, SFRP2, ARHGAP5, SHBG, BTG1, KDM5A, RB1, CCKAR, CDK7, CDH11, PSMB8, CDK1, ADGRE5, CD74, PTGS1, CCNA2, PTPN6, CBR1, C5AR1, SERPINH1, RUNX2, CASP6, RAP1B, RAP1GAP, CALD1, CALCR, DDR1, CA11, ATN1, DSC2, PRDX1, FLNC, IRF3, ITGA2, ITGAV, GJA1, GGT1, ANOS1, GAS6, GAS1, KCNH2, GALNS, KIT, KIFC1, KRT17, KRT18, FUT1, FUS, FRA7G, LCN2, LIF, FOLR1, LIMK1, IRF2, GLO1, IRAK1, HINT1, HOXC6, FOXA2, HMMR, HMGCR, HLA-G, HLA-F, HLA-DOA, HLA-B, HK2, HIC1, GLS, HDGF, MRPL58, IDUA, IGFBP1, IL4R, GPX1, GNAS, ING2, CXCL10, FLOT2, LOXL2, P4HB, LUM, MYO6, PPP1R12A, FBLN1, PTK2B, NELL1, NEO1, NEU1, F3, NEUROD1, NGF, EPHB1, EPHA1, NOVA1, NPC1, NRAS, DDR2, NTSR1, OMP, E2F5, DUSP6, DUSP5, EFEMP1, MYD88, MYCN, FOXF1, LYN, TM4SF1, FLI1, MXD1, FOXS1, FOXJ1, MAPT, MAP3K5, MFAP1, MITF, FKTN, MKI67, MME, MMP3, MMP12, MOS, FHL1, MTAP, NUDT1, TRIM37, SHMT2, HOXA5, XIAP, SLPI, TM7SF2, ST6GAL1, TCF3, STAT5B, STAT5A, TGM2, ASIC1, SPINT1, ADCY3, SMARCA1, SPOCK1, ADH5, TCF21, SSTR3, TEK, HLTF, TDG, SRC, ADH1A, TEAD1, SLC5A5, TAZ, SLC1A5, AMD1, SIX1, SRY, ALCAM, SLC7A1, ADH7, ACTB, ACACA, APOE, SLC9A1, ANXA4, SULT1A1, SLC6A8, TCF7L2, AGTR1, ALOX15, SOD1, AP2A1, TGFB3, SLC22A3, ANXA3, SIAH2, HSPA13, H4-16, MSI2, LINC01254, PIP5KL1, FOXI1, VPS37A, ANKRD9, SOCS4, FLNB, UBXN2B, TMEM52B, PAQR4, TRPM2-AS, NXPE2, NEDD1, NALT1, FOXC2, IQGAP3, SGPP2, CD200R1, LINC01524, RBM45, CMPK2, SCLT1, VSTM2L, LINC01303, KRT40, PDCL2, TSACC, GJB4, TNFAIP8L1, IL31RA, FLNA, OSR1, TMEM45B, LOXL1-AS1, CPXM2, ACTN4, CMTM7, MIR6807, MIR6884, PRRT2, CAVIN3, EGLN3, EGLN2, FUT2, FUT3, FUT4, CGB5, MRFAP1, FUT5, MEF2C-AS1, LEMD1, CSAG2, PGAP3, DNER, DTD1, SPECC1, SCGB3A1, FUT6, GGTLC1, CHRDL1, WDR20, ISX, MIR6856, CDCA5, TMEM106A, FPR2, GSTO2, MMP21, PIK3AP1, ETS1-AS1, TWIST2, RASSF1-AS1, MIR6506, DCD, FLT3, DIRC1, MIR6852, BATF2, CCDC151, FOLR2, ATG4A, FOSB, OSBPL8, ESCO1, TUBGCP5, LMTK3, CARD16, TIRAP, NLRP3, B3GALT5-AS1, LINC00313, S100A16, ZNF664, CTCFL, CTXND1, FAU, DOK6, SKA1, VWCE, FBLN2, CCNY, MED19, SFTA1P, HIPK1, APOBEC3A_B, FCGR2A, PRSS55, CCDC125, BRI3BP, LINC01436, RAB12, CENPX, FBXO45, FDXR, FOXP4-AS1, APOBEC3A, FEB2, ARID2, PRXL2C, FEN1, GPC4, PTCSC3, MARCHF8, KDM1B, LINC-ROR, SBF2-AS1, IFNL2, ADGRF1, IS1, HSPA12A, LINC00565, FABP1, RB1-DT, EPGN, MACC1-AS1, FABP5, MSRB3, CERS6, EBF3, RICTOR, HCG27, NEIL2, IL27, ACSL4, FALEC, MAPK15, FAM83B, HOXC-AS3, JAZF1, FAT1, DNAJB1P1, ABHD11-AS1, ADAMTS18, PTENP1-AS, LDC1P, MFSD4A, LINC00662, LYPD4, ZNF418, ADARB1, ARHGAP27P1, TMED6, LINC00052, NRG4, PWAR1, ADAM8, PTGR2, FOXF2, LINC00477, GUSBP11, LAYN, PIWIL4, CACUL1, ZNF280B, ACYP2, ISM1, LINC00261, LINC01793, ROMO1, FKBP5, FKBP4, ADAMTS15, GPBAR1, BHLHA15, DDX53, FGB, SLFN5, MDGA2, SLC5A8, DEUP1, FGF13, FGFR3, LINGO2, LRATD2, ESCO2, PEBP4, ADH4, FGL1, AMOT, CREBRF, FH, PAQR3, IGSF11, SGO1, ADD1, GPR155, NPTN-IT1, LBX2-AS1, RNF185, HS6ST2, FZD2, GUSB, VASH2, SHCBP1, GSTM3, GSTZ1, ELMO3, GTF2A1, PALB2, GTF2H4, SUV39H2, GUCY2C, IPO4, ZDHHC14, NEIL1, EHMT1, GZMA, HAS1, HMBOX1, ACSS3, TCTN1, HCK, CORO7, SLC52A2, HCRT, BIRC7, LOC107987479, HMGN5, LINC02163, CAMKMT, HDC, GRINA, ADAM33, ULBP1, LINC01852, RAPGEF1, GRN, GRIK2, CPEB4, GRIK3, FLAD1, GRIN2B, RUFY1, RUNX1-IT1, NR3C1, ZMYM1, FRAS1, LINC02465, ZNF703, TRIM46, TUBA4B, DGLUCY, GRP, PDIA3, DENND2D, GSTA1, CCDC134, GSTA3, HCRTR1, CENPO, SPOCD1, HNRNPA2B1, DCLRE1C, RGS18, ASIC2, GREM2, MMP25, H3P42, HMGA1, RHBDF1, ARHGEF28, ROBO3, STRA6, H3P11, ABL2, CPEB1, IRF2BPL, NCAPG, HNRNPC, HNRNPD, HNRNPK, TLX1, HOXA@, HOXA1, TP53AIP1, CLSPN, PKNOX2, FKBP10, CSMD1, ANAPC1, DHRS11, ZBTB10, DINOL, KRT7-AS, HELLS, MBOAT7, RNF26, CARD14, DCTPP1, ACHE, NUP37, LOC111589215, LRFN4, DDRGK1, STK33, TMPRSS3, HK1, LNCRNA-ATB, DUS4L-BCAP29, CDK15, HLA-C, MRPL41, HLA-DQA2, MICAL1, FNDC3B, HLA-DRB1, CCDC136, NUCKS1, COASY, PDCD1LG2, GPR37, GDF2, GATA2, ACP1, ORAI1, GATA3, RIOX2, ARHGAP5-AS1, FOXD2-AS1, GBAP1, KAT2A, KDM2B, GDF1, CCDC62, GEM, ATAD1, AFAP1L2, GFPT1, MAP1LC3A, GACAT1, GHRH, ZMAT1, DOT1L, GHSR, COG8, BRMS1L, GINS4, WDR83, SPPL2A, ARHGEF39, GPR35, HAGLROS, LINC00473, AOC4P, TMEM41A, MED30, LOC102724197, DCAF15, GAB1, SYT8, KLHL6, GAGE7, GALE, TSLP, LBX2, SLC35B4, DIXDC1, TSPYL5, SLC22A16, GALNT1, DNAJC14, GALNT2, ACP5, LINC01419, TNS4, MAEL, MASTL, FIBCD1, POLDIP3, TCHP, IRAIN, SLC38A1, NETO2, TLR10, NUAK2, VCAN-AS1, MDC1-AS1, GNAQ, CAB39L, FAM83D, ACLY, GNAT1, PDRG1, TXNDC5, SGPP1, NLRC5, HM13, ILKAP, EGFL8, ZNRD1ASP, GNB3, KDM7A, TAS1R1, GNL1, GOLGA2, SFN, ITIH5, PRLHR, VANGL1, KRTAP1-1, GLUL, TCONS_00068220, RNASEH2C, GJA4, ZNRF3, USP44, ACO2, HORMAD1, GJA8, GJB1, BRIP1, GPC3, GLB1, KLF16, ANGPTL6, ITCH, TLCD3B, CALN1, LNCOG, TRAPPC9, GCLC, FAM107B, BCL2L12, SOX7, THRA1/BTR, MYOSLID, VPS13B-DT, F2RL2, ADH6, F2, MIR487A, MIR1266, GAGE12G, SMIM10L2B, CACNA2D1, CAD, PURPL, FLVCR1-DT, CERNA2, MIR664A, ANPEP, SLC7A11-AS1, CALM1, CALM2, ANXA11, MIR484, CALM3, SNORA21, CANX, CAPG, CAPN1, MIR1281, MIR1304, MIR504, CAPN2, MIR502, CAPZA1, C4BPA, GAS6-AS1, SCFV, C3, MIR1269A, MIR1294, MIR577, MIR575, BOK, MIR573, MIR570, MIR567, MIR564, MIR558, FOXL2, ZFP36L2, BTC, MIR411, KLF9, BTF3, MIR544A, MIR539, BTK, FAM72B, C1QBP, MIR1306, LGALS7B, PRB2, CXADRP1, MIR500A, CAST, CASP1, CD8A, MIR31HG, CD9, CD19, DUXAP10, DUXAP9, DUXAP8, CD28, CD33, CD40LG, MIR422A, MIR384, CD59, MIR382, CD63, MIR711, CD81, ALPP, MIR376A1, MIR449C, LRBA, CDC6, SUMO1P3, CDC27, CDH4, MIR373, CD8B, MIR718, ANG, CD247, MIR518C, MIR498, CASP7, CAT, MIR1290, CBFB, MIR1303, CBS, MIR511, NCRUPAR, KRIT1, MIR488, MIR485, MIR376B, ALPG, MIR410, SLC25A5-AS1, MIR452, CCNG1, MIR433, CCNG2, CCNH, CCT, CD1D, H4C15, MIR582, BMP8B, LINC02532, MIR877, MIR509-3, ARSF, MIR1265, ASNS, ASS1, ATF4, MIR935, MIR922, MIR301B, MIR374B, ATP6V1A, MIR665, ATP7A, MIR588, MIR1286, ATRX, VTRNA2-1, MIR300, AVP, MIR1275, SNORD105B, APOC1, AZGP1, B2M, GAGE12F, PWRN1, MIR937, MIR944, STS, MIR190B, ADPGK-AS1, APP, TONSL-AS1, H3P36, GACAT2, DEFB4B, AQP4, MANCR, MIR1225, MIR1224, TRIM23, GAGE12D, FOXO6, INSYN2B, RAB6C-AS1, AGAP2-AS1, MIPEPP2, MSTO2P, VPS9D1-AS1, ARF1, ARF6, RHOB, MIR939, MIR933, ARR3, HPP1, MIR802, MIR1182, CEACAM1, MIR633, MIR632, CXCR5, MIR628, MIR625, MIR623, MIR622, MIR618, MIR616, APAF1, MIR615, BMP1, MIR608, MIR605, MIR604, MIR603, MIR601, MIR600, MIR599, BMP3, MIR596, BMP4, MIR592, MIR590, MIR589, MIR637, MIR645, MIR758, BCYRN1, TDRG1, MIR1246, MIR1247, FAM72A, GAGE12E, GAGE12B, GAGE12C, CCR2, STXBP5-AS1, ADGRB1, OIP5-AS1, NKX3-2, BCAT1, LINC01433, BCHE, BCL2A1, LINC00165, MIR1298, APBA2, MIR660, MIR658, MIR654, MIR1229, MIR652, MIR650, CDH5, MIR369, P4HA3, EFNA1, DUSP9, E2F2, MIR124-1, ADORA2A, ECE1, MIR10A, ECT2, LPAR1, EDN1, EDNRB, EEF2, MIRLET7G, EFNA2, DDC, EFNB1, ADORA1, EFNB2, MIRLET7A2, MIRLET7A1, MEGF8, LDLRAD2, HPPD, EGR2, C3orf85, HAGLR, LINC00668, DNM3OS, DUSP1, MIR2392, DTX1, MIR16-1, MIR15B, MIR15A, RBM14-RBM4, DHX15, DEFB4A, GRK2, DHPS, MIR147A, MIIP, DLD, ADRA1B, MIR4668, MIR4728, DOCK1, ADRA1D, MIR4513, DPP4, MIR4665, DRD2, MIR3064, DSG2, MIR4429, DSP, SLC26A2, TOB1-AS1, EIF4A1, FENDRR, RSPO2, MAP3K20-AS1, EPHA4, BRINP3, MT1DP, EPHA8, TUSC1, MIR5003, EPHX1, ERCC3, ESRRG, CCDC66, TUSC7, TMEM238L, LINC00319, ETS2, WDR62, ETV4, CXCL17, GSDMA, NEK8, PICART1, LINC00324, LINC00346, EYA1, HECTD4, ARSI, EPHA3, BCAR4, NCCRP1, MIR100HG, SMIM10L2A, CSAG3, EIF4EBP1, ELAVL3, VGLL3, ELF3, LINC01138, TMEM220, ELK1, KMT5A, ELK4, MARK2, AQP12A, LINC01116, ASPG, NCR3LG1, EMP1, IRF2BP2, EMP3, ARPIN, PWAR4, EMX2, IRGM, HSD17B13, LINC01606, EGFR-AS1, MIR4317, ALOX12, MIR4284, MIR4268, MIR99A, MIR96, CLK2, MIR4308, CLTB, MIR92A2, MIR7-3, MIR7-2, MIR7-1, MIR4269, ABCC2, DDB2, CNC2, PLK3, CNN2, CNN3, CNTN1, MIR3664, COL4A2, MIR302A, AKR1B1, COL5A1, COL5A2, COL10A1, BLID, PIM3, PRDM16-DT, PIWIL3, MIR3174, CDK9, MIR4270, MIR345, MIR342, MIR3129, MIR339, CEBPB, CENPF, MIR4295, CFTR, MIR330, CGA, MIR3189, CHD1, CHGA, MIR302D, CHI3L1, CHRM2, CHRM3, CHRNA3, CHRNA5, KRT19P3, CHRNB2, CISH, COL11A1, LINC01133, MAGI2-AS3, CTBP2, CTNND1, CTSD, CTSE, LINC00629, MIR19B2, CTSZ, GIHCG, CX3CR1, CXADR, TTN-AS1, AHSG, CYP2B6, CYP2D6, CYP3A4, DAB2, MIR191, DACH1, CD55, ADAMTS9-AS2, LINC00707, DAPK3, MIR184, DAXX, AGA, AEBP1, CTNNA1, PCAT6, MIR299, OCLN, COL11A2, COMT, LUCAT1, COPA, CLDN7, CPT1A, MIR26B, HMGA1P4, MIR24-2, LINC00958, HOTAIRM1, LINC01006, CSE1L, CSF1, CSF1R, MIR219A2, CSF3, CSF3R, CSK, CSNK2A1, CSRP2, AIF1, CST6, CSTB, CTAA1, TNFAIP2, CD177, TGIF2, MDC1, TNFSF15, SLC23A2, PTPN3, PTPN4, KIF14, ARNT2, NUAK1, TLK1, PTPN9, PTPRC, TRIM14, KEAP1, PTPRCAP, PTPRH, PTX3, DLGAP5, PIEZO1, PVR, RASSF2, NECTIN1, TOX, PXN, RAB13, RAB27A, KNTC1, RAD51B, RANGAP1, RAP1A, RAPSN, NR1I3, NR1H4, PTN, DNAJB6, PSMC3, ARL4C, PSMD1, ARPC2, TSPAN1, PSMD2, ACTR3, ARPC1B, PTPRU, NR1H3, PSMD4, PSME2, UBA2, RANBP9, PTK7, PSPH, TROAP, FRAT1, BCL2L11, BCL2L10, PDCD6, TAS2R38, PTGDS, ABI1, PTGER3, PTGER4, PTK6, HNRNPDL, IPO13, CTR9, NAMPT, MICAL2, SLIT2, OPN1LW, REN, TAOK2, UPF1, REV3L, RFC1, RFC3, COPB2, RGS3, RMRP, AIMP1, PTTG1, BRD2, RNF6, RNH1, HACD1, SLC16A7, DEDD, DDX21, ROBO2, RASSF9, ARHGEF2, OSMR, IL1RL1, RORC, RPA3, EBAG9, PCSK7, ITGBL1, RBM3, RBBP8, BAG4, IKBKE, RGS6, RARA, CYTIP, APOBEC3B, RARRES2, NR1D1, MACROH2A1, MRPL33, CXCL14, NRG2, TP53I3, BAG3, PLAAT4, RECQL4, RASA1, GAL3ST1, RASGRF1, KIF23, MAPK8IP1, ROCK2, RASAL2, MAP4K4, ITM2B, RBBP4, HAND1, FADS2, RBBP6, BCAP31, PSMA7, RPE65, TRIM3, PDYN, PECAM1, PENK, PFKFB4, PFN1, GJB6, CDK14, PLK2, PGR, GIPC1, PLK4, SLC25A3, DLL3, TNFSF13B, PHF2, SERPINB6, SERPINE2, CELF2, CELF1, SERPINI1, KHDRBS3, PIK3R1, CAMKK2, IGF2BP2, PKD1, PLAT, PLCD1, PLD1, TRIM16, PDPK1, HCST, PDK3, KIF2C, DNAJB4, PAWR, PCCA, WWP2, ADRM1, UPK1A, PIM2, RAB31, RAB35, ATF7, KLK11, IL24, LILRB4, RAB32, PPARGC1A, COPS6, CKAP4, RAB40B, PCDH9, SERPINA5, LMAN2, PCSK2, CDK16, PDCD2, EHMT2, MAGED2, PDE4D, SUGT1, SPAG5, PLOD2, G3BP1, PAIP1, PPAT, PPIB, PPP1CA, PPP2CA, PPP2R5E, IRF9, CITED2, PRKACB, PRKACG, PRKCA, PRKCH, SMYD5, CRISP3, CCNO, DLEU1, MARCHF6, DNAJA2, EFS, PRKCZ, MAPK7, MAPK9, PRSS3, HNRNPR, RELN, RCAN2, TRIM13, PSME3, PSAP, PSMA1, IFITM3, RAPGEF3, MED1, ENOX2, PLS3, SMC2, IFITM2, SORBS1, PML, PMP22, PNMT, PROCR, ANP32B, UBD, POLR2A, KAT5, SEMA3C, CRTAP, PPARA, CAP1, CAP2, NXF1, HOXB13, PON2, PIBF1, POU2F1, TACC3, GPNMB, POU2F2, FAM3C, MCRS1, RBM14, EXO1, RPL10, AFAP1, WT1, SOX1, NTT, DEK, REEP5, SEMA3B, SOX5, SOX10, PAX8, SOX12, DAP3, SPG7, ZNF217, ZNF208, TRIM25, ZNF143, ZNF70, SPTAN1, CNBP, ZNF3, SSRP1, SSTR1, ST13, STAT6, STAU1, STX1A, SUV39H1, TACC1, TACR1, MAP3K7, FZD3, SEM1, SNX1, GDF5, FZD9, FZD8, FZD6, SLC11A1, SLC19A1, SLCO2A1, SLC22A1, H4C9, SLIT3, KDM5C, USP9X, TAM, SMARCA2, SMARCB1, NR4A3, AKAP1, SMARCC1, SMARCC2, SMARCE1, SMN1, SMN2, SMO, USP5, SNRPA, CSRP3, RASSF7, ADAM12, CUBN, XBP1, WRN, H4C4, WNT9A, SUMO1, UBE2N, UBB, UBA52, TH, TNFRSF4, THRA, THRB, TIA1, TSG101, TRPM2, NKX2-1, TRPC1, HSP90B2P, TRAF6, TRAF5, TRAF3, TK1, TKT, CRISP2, TPR, TLE1, SEC62, TPD52L2, TMPO, TMSB4X, TMSB4XP8, TNNI2, TNFRSF1B, TGM1, UGCG, UGT1A, TCF7, WNT2B, TAPBP, WNT8B, WNT7B, TBL1X, TBX2, WNT3, TCEA1, HNF1A, NSD2, VWF, VLDLR, VIPR1, TCF12, UGT2B15, VHL, TCN1, VCL, VCAM1, VAV2, VAV1, VASP, KDM6A, TEP1, UQCRFS1, UQCRC1, UPP1, TFRC, H4C1, H4C6, RABEP1, SRSF6, PER2, APLN, ATXN1, AKAP4, ALKBH1, SCN7A, SCN9A, SCNN1B, CCL4, CCL18, CFLAR, GGH, CCL20, FGF18, BANF1, CDKL1, IL18R1, SDC1, TNFRSF10A, SDHB, TNFRSF11A, FBP2, DLK1, SDHC, SDHD, RIPK2, TNFRSF14, SET, ADAM23, TSPAN31, SAI1, VPS52, PRC1, RPL11, RPL34, SLC16A4, RPN2, RPS6KB2, NMI, USP14, PKMYT1, RPS7, RPS12, CLDN2, CLDN6, SYT7, RPS13, MTMR2, RRAS, BAZ1B, RRM1, MAP3K14, CDKL2, NOL3, LIMD1, S100A3, S100A7, BTRC, S100A9, MBD4, SGCE, SFRP5, TNFSF14, H4C12, HRK, PPFIA3, BARX2, CBX4, YBX3, ST3GAL3, IFITM1, ELP1, STIL, LIPF, SIPA1, SLC2A4, SMARCA5, KLF11, SLC3A2, SLC4A1, SLC6A6, STK24, SNHG3, TAGLN2, SLC8A1, SPARCL1, MAD1L1, H4C14, H4C13, H4C5, H4C2, H4C8, H4C3, H4C11, LMO4, PIAS1, CDC14A, TNKS, RIPK1, GPAA1, ADAM19, CTSF, MBTPS1, ABCC3, PEA15, SRSF7, EIF4G3, EIF3H, EIF3D, EIF3B, SGK1, SGTA, TCAP, SH3BGRL, LAMTOR3, NCOA1, JRK, SHC1, USO1, SHH, KLF7, TNFSF11, STK16, MADD, PDXK, CDK10, ADAM29, PAK2, ADAMTS8, UGT1A10, PARPBP, ITGA3, C1orf56, ODAM, IMPAD1, CMTM6, CYP2W1, SLC66A1, ITGAX, ALKBH5, EIF6, ANKRD49, ITGB5, ITGB6, ITK, GIPC2, TRIT1, TET2, BTG4, TRIM44, ITPR3, MPHOSPH8, JAK1, UGT1A4, HES2, CCNJ, LZTFL1, UGT1A6, JUNB, MARCHF1, ANKRD40CL, USP47, CHDH, ILF2, ILF3, ENOSF1, IL17RB, MAML3, TRIM36, INCENP, TNFRSF19, IDO1, LGR4, IMPACT, STYK1, INS, INSIG1, FKBP14, INSL3, TMEM100, KIRREL1, RIF1, PRMT6, CEP55, SDAD1, IRF4, KIF26B, RNF31, ITGA1, EPN3, NOL8, UGT1A8, JUND, OTUB1, ING3, KNG1, AZIN1, KIF11, CYRIB, UFM1, HDAC7, KPNA2, RAB6B, KRT6A, KRT7, KRT15, VTA1, CXXC5, GTSE1, UFC1, NOP16, HSD17B7, LAG3, PRRX2, RNF138, VGLL1, SNX9, PPME1, LAMA4, PLA1A, ZMYND10, WT1-AS, LAMB3, ZBTB7A, KLK1, LSR, PPIL1, DUOX1, RBM47, KCND2, KCND3, FBXW5, KCNH1, ANLN, SSH1, TERF2IP, TREM2, NANS, MRPL39, POLE3, LINC00111, KCNMA1, MPC1, IL17D, MYOZ2, MAP3K20, STK26, INPP5K, CDK12, TMEM8B, KCNQ1, WBP11, KIR3DL1, CMPK1, CAB39, SUFU, VPS50, NLRP2, ADAMTS5, KNL1, DOCK6, IFT80, STAMBPL1, HRH2, KIAA1324, MIB1, HACE1, MTUS1, AHRR, GRAMD1B, HSD3B1, NDRG3, HSD11B2, RAB22A, HSD17B1, HSD17B2, HSPA1A, HSPA1B, ARFGEF3, HSPA2, HSPA9, DNAJB1, ZNFX1, TNC, PELI2, IDH1, CLEC3B, IDH2, PLAAT1, ZNF471, AGFG1, HPN, RAB40C, LGR6, TRPV4, HOXA9, HOXA11, ABRACL, SINHCAF, DLGAP3, HOXB5, PRUNE1, HOXB9, CREBZF, CXCL16, HOXC9, TRIB3, HPD, GBA3, HOXD3, METTL14, PRX, SFMBT2, DENND1A, CHD8, EPB41L5, ZBTB4, HOXD9, USP28, LRRN1, ZBTB2, PDSS2, PCBP4, DDX27, TWSG1, MYDGF, KLHL7, DMAP1, ACSS2, LMO3, IL7, IL9, HDAC8, WWC3, SELENOS, DCAF6, PAG1, KDM3A, ST6GALNAC1, DCP1A, IL12A, CACNA2D3, IL12RB1, NGLY1, CCAR1, CNDP2, IL12RB2, IL13, IL15, VPS35, TENM3, IARS2, LIMS2, FOXK2, PCDHGA9, PCDHA@, IHH, IFRD1, IFIT2, IFNA1, IFNA13, IFNAR1, IFNB1, IFNGR2, CEACAM19, SMYD2, PMEPA1, LXN, IFNW1, UBQLN4, TCIM, TCEAL7, GSDMC, SLC2A4RG, RETN, AKIP1, MUC13, LINC00470, IGF2R, DNAJC12, IGFBP5, IGFBP6, PARD3, RBPJ, CTNNBL1, SUSD2, LASP1, LBP, RSRC1, GSE1, KAT6B, NF1, NFIA, PES1, SEC11A, NFIB, ETHE1, CBX5, NFIC, OTP, NFIX, NFKB2, NFKBIA, NFKBIB, FRAT2, UBR4, NID1, NEDD4L, NME2, SATB2, ICOSLG, UBR2, NQO2, ADGRL2, NODAL, VPS13A, RHOBTB2, NONO, RRS1, PRAME, SEC14L2, GTPBP4, SPDEF, SYF2, MYH11, CLIC4, SOSTDC1, MYLK, MYO5B, TRIM58, MYOD1, FBXL2, NAB1, TAFA5, NAGLU, BAMBI, RAB3GAP2, ARL2BP, NASP, IL17RA, GABARAPL1, GSPT2, NCAM1, PRKD3, NCF2, NDUFB6, NEK3, FAM215A, DDX58, NEU2, DDAH1, CCN3, FBXL7, SLC25A37, KANK1, IKZF3, COG2, NTS, OIP5, NUCB2, NUP98, ATXN2L, PTGDR2, ZHX1, OAZ2, GALNT6, FZD10, TNFRSF11B, OPRD1, OSM, OTX1, P2RX7, MAP4K1, WDHD1, PSIP1, P2RY2, P2RY6, HHLA2, KAT7, FAF1, BTN3A2, EMILIN1, KRR1, PRSS23, MRAS, PHLDA1, DLGAP4, NTRK1, NPR1, PHF8, PLXND1, NPTX1, SARM1, KIF1B, ARHGAP26, ZC3H13, PEG10, ZNF609, MYT1L, USP33, NTHL1, TPX2, RAB11FIP2, TRIM32, NTRK2, NTRK3, RAB18, MAPRE1, MMRN1, ROR1, ROR2, ZHX2, MORC2, CILK1, VASH1, PPM1E, KANK2, NUDT13, SH2B1, KRT23, LY6E, LYZ, KLK12, CAPRIN1, PIK3R4, MARCKS, CXXC1, VSX1, SMAD1, MAGEA3, NOP53, RHOD, DONSON, UBQLN1, IL19, MAGEA4, MAGEA6, MAGEA12, ICOS, YPEL1, CARD10, TMOD4, MAT2A, MBS1, MCAM, PRSS50, TBK1, MEF2D, LINC00339, DHH, LTBP2, CYP4F3, SERPINA10, ARMCX1, KCNK9, TIMMDC1, THEG, LEPR, CLEC1B, MZB1, LGALS2, NUSAP1, LGALS3BP, PLEKHO1, LGALS7, LIFR, LIG3, BHD, SDF4, A4GNT, LLGL2, LMO1, SH3GLB1, LNPEP, LOXL1, LPA, LRP6, LRP5, DESI2, LRPAP1, DERL2, UBE2T, ATAD2, KLF15, FBXO24, GAGE12I, CKAP2, ND3, IL36RN, LATS2, TIMM9, SEZ6L2, GNL3, HSPB8, MTX1, MYCBP, TINF2, FBXO8, PTTG3P, DNAJC2, MUC3A, FBXO2, DGCR5, PITPNC1, SENP3, MUSK, MMUT, MYB, GPSM1, KLK13, MYBL2, SETBP1, CHD5, HAVCR1, FOXD3, MFAP2, TOX3, HIPK2, NOB1, MELTF, SCGB2A1, MGAT5, CD99, TRAC, MICB, SGSM3, DESI1, TMEM97, FOXO4, TNRC6A, RBMS3, CYTB, SRPX2, PCDH17, MMP8, IL37, GLS2, MMP16, CD200, DKK4, BBC3, MT1F, MTBP, SND1, LAT, H3P29
- Gastric Cancer OMIM
  
  Clinical Features Scott et al. (1990) described a family in which 2 of 4 sibs under the age of 40 years presented with gastric cancer. A third sib had antrectomy for gastric dysplasia, and a fourth, aged 36, had extensive chronic atrophic gastritis and intestinal metaplasia.
- Stomach Cancer Mayo Clinic
  
  Overview Stomach cancer, which is also called gastric cancer, is a growth of cells that starts in the stomach. The stomach is in the upper middle part of the belly, just below the ribs. The stomach helps to break down and digest food. Stomach cancer can happen in any part of the stomach. In most of the world, stomach cancers happen in the main part of the stomach. This part is called the stomach body. In the United States, stomach cancer is more likely to start by the gastroesophageal junction.
Monorchism Wikipedia

April 13, 2011 . Retrieved 2012-02-19 . ^ "NBA Playoffs 2001 - Starks has twisted testicle removed" . www.espn.com . ^ "Warrington Wolves: Paul Wood has testicle removed" .

TCTN3
Unibrow Wikipedia

A study found the prevalence of synophrys to be at 11.87% in the Omani population. [5] Tajikistan [ edit ] In Tajikistan , [6] a unibrow is viewed as an attractive quality in both men and women. [ citation needed ] For women, it is associated with virginity and purity and, in men, virility. [ citation needed ] If there is no unibrow present, or if it is weak, it is commonplace for women to use a kohl liner or a modern kajal pen to simulate a unibrow. [ citation needed ] Elsewhere [ edit ] The unibrow has largely been seen as undesirable in the Americas and Europe, with the hairs often plucked , shaved , or waxed away. [7] [8] [9] Frida Kahlo The artist Frida Kahlo was famous for her unibrow, which she often depicted in self-portraits. [10] [11] Model Sophia Hadjipanteli is also known for her unibrow. [12] It is also the trademark of NBA player Anthony Davis , [13] football player Marouane Fellaini and YouTuber ElectroBOOM . ... Retrieved 2018-08-27 . ^ "An Open Letter to the AGO About Frida Kahlo's Unibrow – Shameless Magazine" . shamelessmag.com . ^ "Why Frida Kahlo's unibrow is important" . NET-A-PORTER . ^ "Meet the model 'owning' her unibrow" .

ASXL3, ATP6V1B2, LEMD3, WNT4, NANS, WAC, CDON, KCNK4, SLC25A24, ANKRD11, ZBTB20, KIFBP, SETBP1, NIPBL, PIGN, NSUN2, ABCA5, PACS2, PHF8, IQSEC2, DHX30, CHSY1, ERLIN2, IL1RAPL1, POLR3A, RAI1, DEAF1, TMCO1, PHIP, ABCC9, SETD5, ASXL1, ARX, FREM1, KCTD7, HGSNAT, UQCC2, UTP23, TRAPPC9, GPR101, TTI2, EHMT1, ROGDI, THOC6, VPS33A, XYLT1, KNL1, CCDC47, KLHL7, HDAC8, MBD5, PACS1, TRMT1, CWF19L1, CERT1, GNE, BMP2, GJB2, KMT2A, MITF, MEFV, MAB21L1, KIT, KCNH1, IGF1R, HSPA9, HNRNPU, GRIN2B, GNS, FLII, NFIX, FHL1, FGFR2, FGFR1, FGF3, BPTF, EDNRB, EDN3, CSNK2A1, CREBBP, CDH11, CDC42, NAGLU, NOTCH2, RUSC2, TRIO, TMEM94, SMC3, AIP, EED, CDK10, CUL4B, SMC1A, HMGA2, ZNF711, ZIC2, UBE2A, TALDO1, PAX3, TAF6, TAF1, SOX10, SMS, SNAI2, SGSH, RAD21, NECTIN1, PSMD12, PPP2R1A, PMM2, EBF3
Hallux Rigidus Wikipedia

Difficulty with certain activities (running, squatting) Swelling and inflammation around the joint Although the condition is degenerative, it can occur in patients who are relatively young, particularly active sports people who have at some time suffered trauma to the joint (turf toe). A notable example is NBA star Shaquille O'Neal [2] who returned to basketball after surgery.

SLC40A1
Tumor Of The Stomach Wikipedia

Tumor of the stomach Other names Stomach tumor A stomach ulcer that was diagnosed as cancer on biopsy and surgically removed Specialty Gastroenterology Oncology Symptoms Early : Heartburn , bloating , upper abdominal pain , nausea , belching , loss of appetite . [1] Later : Weight loss , yellowing of the skin and whites of the eyes , vomiting blood , difficulty swallowing , blood in the stool [1] Complications Stomach cancer Causes Helicobacter pylori , genetics This page will be copied to Wiktionary using the transwiki process. The information in this article appears to be suited for inclusion in a dictionary, and this article's topic meets Wiktionary's criteria for inclusion , has not been transwikied , and is not already represented . It will be copied into Wiktionary's transwiki space from which it can be formatted appropriately. If this page does not meet the criteria, please remove this notice. Otherwise, the notice will be automatically removed after transwiki completes. If this template is placed on a glossary article , it should be removed immediately after the transwiki is completed, and not replaced with {{ TWCleanup }}, as there is no consensus for the deletion of glossary articles .

ERBB2, APC, PIK3CA, FGFR2, MUTYH, KLF6, CDH1, CASP10, IRF1, MET, CDKN1A, ATM, TP53, KRAS, CDKN2A, ERBB3, AXIN2, DLC1, CDK4, BAP1, PTGS2, STAT3, RUNX3, IL1B, MTHFR, EGFR, BIRC5, IL1RN, TYMS, TNF, ZNRD1, GKN1, CCND1, GAST, FHIT, MUC1, TYMP, IL6, PRNP, MAPK1, MMP7, BRAF, CD44, PSCA, ACE, DPYD, XRCC1, UMPS, TWIST1, HMOX1, IGFBP3, JUN, MAPK3, PPARG, MYC, CHFR, SERPINE1, HOTAIR, REG4, RHOA, MIA, MMP10, PLAU, SOD2, CLDN3, ERCC2, HRAS, DCBLD2, LRRC3B, PTPRG, PYCARD, SMAD4, CDH2, CKB, FAT4, CDKN1B, KLK10, TIMP3, CAV1, WWOX, HBEGF, KISS1, PHB, DNMT3B, GSTP1, RPL15, DNMT1, BIRC2, XAF1, KRT20, ARL6IP5, LGALS3, AHR, NPM1, ING1, SPRR2A, TNFRSF9, SNAI1, ALDH1A3, SLC1A2, ALB, SNRPB, IL6R, CXCL8, ALDOB, IGFBP7, HTR1A, SREBF2, ALOX5, TAF15, APEX1, FYN, SPZ1, ZNF177, XRCC3, TUBA1C, GLI3, BDNF, ANXA5, MIR22HG, ZNF160, TPM3, MBD3L2, THBD, HNRNPL, HOXA2, TGFA, TFAP2C, HSPA8, HSPB1, HSPD1, ITGA5, ICAM2, TBX3, ID4, IDH3B, RXRB, EXOSC5, RPS26, PLIN2, PTPA, PPP2R1A, PPIC, PPIA, ADRB1, POLE, MSX1, MT2A, PRR5-ARHGAP8, PLAGL1, ZNF667-AS1, MUC6, MX1, RPS21, CCAT1, NDUFA2, NDUFS1, NDUFV1, SERPINA1, PGAM1, NOS3, NOTCH2, PDHA1, NT5E, PAX6, PA2G4, ADRB2, PREP, KMT2A, MLF1, RPS19, RPS15, RPS6, RPL18, AGTR2, KRT8, SYMPK, RORA, RGS2, RBP4, FADS1, RBP1, RARRES1, RARB, RAD23A, M6PR, PTPRF, ACTC1, MARK1, MAPK8, ATP6V0D2, AFP, PRKCB, PRKAB1, PRKAA1, RPL13, TNFSF9, ARID1A, ALDH7A1, EPHX3, CDKN2D, MRPS18B, CTSC, PRPF19, FILIP1, CLCN3, CLN3, SNX5, ACAD8, GREM1, PUS1, ZBTB20, SERBP1, CST1, PRDX5, CTNNA2, CTSL, BOP1, APOA1, FAM168A, CHEK2, WIF1, ULBP2, DDB1, GADD45A, DES, FSD1, MRPL13, DPAGT1, ABT1, RANBP10, BCL2L1, BID, BLVRB, BMP2, BMP7, BNIP3, NAXD, KMT2C, RNF43, CA1, CA2, PTOV1, CASP8, HRH4, POLR3K, MRPS11, NBAS, HIKESHI, UBR5, GMPR2, PLCE1, ZNF593, UBXN1, COPS7A, CPSF1, ATR, CCT7, CYP2A6, URM1, SELENBP1, SCRN1, MTSS1, TMEM63A, ENO1, WDR46, IL32, NOP56, ERCC1, AURKB, RRP9, SLC16A3, F2R, FCGBP, TRAP1, SUCLG1, SERPINB2, FBP1, IRS2, ZNF559, FGG, KISS1R, AKR1C3, PLPP1, FKBP2, CST7, ITGA8, AREG, ARFGAP2, EEF1A2, EEF1A1, EBI3, CNPY2, ECM1, MSLN, ECHS1, FST, TFF1, REG1A, IL6ST, ANXA1, TXNIP, MLH1, CTNNB1, TERT, AKT1, PDGFRA, MSH2, FLCN, KIT, DCC, SRC, VEGFA, HIF1A, MSH6, TERF2IP, FGFR3, BUB1B, ACD, BUB1, MC1R, POT1, SDHB, MITF, MGMT, CDKN2B, SDHC, EP300, SDHA, NRAS, PTEN, NFKB1, CDX2, MMP9, VEGFC, GSTM1, GSTT1, CASP3, ABCB1, PGC, SPP1, NOS2, MMP2, PTP4A3, HPSE, CLDN4, SOX2, TGFB1, SERPINB5, PLAUR, POSTN, WNT2, TFF2, MIR21, PPP1R1B, CXCR4, RELA, AURKA, SHH, SSTR3, H3P10, IL1A, CYP2E1, MUC4, CCKBR, FASLG, FLT1, MUC5AC, GLI1, E2F1, MUC2, ANGPT2, MAD2L1, ZFHX3, NR4A1, OGG1, CXCL12, SELE, CD34, FOLR1, ASCL2, ADAMTS1, FAS, CEACAM5, SEM1, TIMP2, TP53INP1, KRT19, TNFRSF6B, LEP, CFLAR, LEPR, IL18, SP1, CD9, TEK, HGF, HDAC1, TGFBR1, CASP6, BRCA1, PDIA3, GHRL, CIAPIN1, HLTF, WNT5A, WNT8B, BCL2, BAX, IGF1R, IL10, PRDM2, EZH2, HLA-DQB1, SMAD3, EPHB2, CYP2C19, MMP14, MMP1, POU5F1, MIR222, RASSF1, MDM2, MIR196B, PLA2G2A, ADIPOQ, MBL2, MIR27A, NGFR, KLF4, MAGEA1, PTCH1, KLRK1, IQGAP2, ARID3B, UGT1A9, DACT1, CCND2, DACH1, MZB1, CLDN18, TRAK1, RUNX1, CCNG2, DNMT3A, MPHOSPH8, ADIPOR1, HTATIP2, CA9, CCNA2, DEFB4A, UGT1A10, CXCR6, DDR1, DAPK1, CASP2, KIF2C, MAGED2, LILRB1, CBFB, FXYD5, DCN, ZFR, RAB23, DDIT3, CASP7, IGF2BP3, CD80, CD247, CACYBP, DAPK2, NOX1, TMEFF2, CCR7, FOXD3, CADM1, COL1A2, GNL3, CCN2, PRKD2, TINF2, MAPK14, CSNK1D, KLK13, SETBP1, SOSTDC1, CSNK1E, B3GAT1, DKK3, SULF1, CMA1, NELFB, IGK, KLK12, RHOBTB2, CXADR, CLCF1, CD40LG, CD81, CDC20, NNT, CDC25C, COMMD5, LPAR3, TRAC, CHEK1, DHDH, FOXN3, FOXP1, CTNNBIP1, TRPM7, PGPEP1, MIR146A, MIR145, NCR3LG1, ANKRD33, TRIM59, MRGPRX1, AGT, GPRC6A, AGTR1, DNAJB1P1, ABHD11-AS1, DDX53, OXER1, IGSF11, GATA5, CLDN23, GPR151, ALDH3A1, ANGPT1, B4GALNT2, MRGPRX4, MRGPRX3, CAVIN3, MIR15A, MIR16-1, MIR196A2, PGA3, PERCC1, ZFPM2-AS1, NNT-AS1, ADAM10, MIR1226, ADH7, ADRA1A, MIR589, MIR567, LGALS7B, MIR487A, MIR200B, ADRA2B, MIR337, MIR135B, GPR166P, VN1R17P, MIR301A, MIR25, MIR223, AP2A1, MIR200C, PGAP3, ANXA2, TSPYL5, BGN, LGR6, HIVEP3, BDKRB1, PCDH10, AICDA, ACKR3, ADAMTS9, BDKRB2, KCMF1, RPRM, CNDP2, SOX17, CEACAM1, LIMS2, URGCP, LAPTM4B, FBXW7, IMP3, CDCA8, PINX1, IMPAD1, BRS3, BACH2, BAK1, ANXA4, ABHD11, TNS4, ZNF382, SPPL2A, ANXA7, APAF1, APOE, MIEN1, AR, RHOC, DYNLRB1, RND3, BAD, COL18A1, ARHGDIB, TET1, MYCT1, ASPH, VASH2, NEIL1, ADIPOR2, ATOH1, FA2H, DUSP1, OPCML, E2F4, SAT1, SDHD, INPPL1, INSIG1, PDX1, SDC1, CXCL5, CCL22, CCL17, CCL5, CCL2, S100A11, SFRP1, S100A8, S100A6, IRAK1, RPS27, ITGB1, ITPR3, KCNA5, KCNH1, RPS13, KCNH2, SELL, SIAH1, TDGF1, SSAV1, ID1, TAZ, TACC1, TAC1, STK11, ID3, HSPA13, CFI, SSTR4, IFNGR2, SRF, IL12B, CCN1, RBPJ, SPINK1, IL2, IL11, IL12A, SMO, SLPI, SLC5A5, SLC4A2, KDR, KRT18, RPL6, PITX1, MMP11, MOS, MPO, MRE11, POU2F1, ABCC1, PLK1, PLCG2, RNR1, PKD1, PIK3CG, RPSA, CEACAM6, NEDD4, NM, NME1, NNMT, PFKFB4, PFKFB3, PFKFB2, PFKFB1, NPR1, MKI67, MIF, PRKCA, MGAT5, RNASE1, UPF1, LGALS3BP, LGALS7, LOX, RB1, LOXL2, LTA, EPCAM, PTPRZ1, PTPRA, PTK2, PTGS1, MAGEA3, PSMD10, MAL, HTRA1, KLK6, MCL1, MCM7, PRKDC, TCF7L2, TERF1, PRMT5, PROM1, PTTG1, EREG, LPAR2, PDCD5, ESR1, MTA1, SOCS3, F3, BTRC, F8, FAP, PIWIL1, FADD, ADAM23, FBLN1, HRK, BECN1, FGF7, FHL1, VEGFD, TNFSF11, IFITM1, EPHB6, RPL23, TERF2, PDCD6, YAP1, ST3GAL6, EDNRA, EFNA1, EFNB1, TNK2, EFNB2, EGF, LRPPRC, ARPC1B, REC8, PAGE4, RBX1, EPHA2, ELAVL1, EIF4A3, RASSF2, ENDOG, AKAP12, TP53I11, GDF15, PCNA, FLT4, PPM1D, RECK, THY1, GSK3B, TUBB2A, TRPC6, TPR, GSPT1, TP53BP2, TOP2A, TLR2, TIMP1, TIA1, THBS1, NR0B2, TH, TGFBR2, HOXA10, HPGD, TFF3, HSD17B2, HSPA1B, HSPA5, TFAP2A, ICAM1, GRIN2B, UPP1, VCAM1, GPR42, FZD4, FN1, FOS, TKTL1, MTOR, FRZB, NR5A2, HMGA2, XRCC6, FZD5, GATA3, GATA4, ZIC1, YES1, XRCC4, GATA6, GJB2, XDH, WNT2B, WNT1, GPI, NAT2
- Stomach Cancer Wikipedia
  
  The CDH1 gene, which codes for E-cadherin, lies on the 16th chromosome. [43] When the gene experiences a particular mutation, gastric cancer develops through a mechanism that is not fully understood. [43] This mutation is considered autosomal dominant meaning that half of a carrier's children will likely experience the same mutation. [43] Diagnosis of hereditary diffuse gastric cancer usually takes place when at least two cases involving a family member, such as a parent or grandparent, are diagnosed, with at least one diagnosed before the age of 50. [43] The diagnosis can also be made if there are at least three cases in the family, in which case age is not considered. [43] The International Cancer Genome Consortium is leading efforts to identify genomic changes involved in stomach cancer. [44] [45] A very small percentage of diffuse-type gastric cancers (see Histopathology below) arise from an inherited abnormal CDH1 gene . ... Hence, this heterogeneous expression should be taken into account for HER2 testing, particularly in small samples such as biopsies, requiring the evaluation of more than one bioptic sample. [80] Radiation [ edit ] Radiation therapy (also called radiotherapy) may be used to treat stomach cancer, often as an adjuvant to chemotherapy and/or surgery. [6] Lymphoma [ edit ] Lymphoma of the MALT type can often be fully treated by treating an underlying H. pylori infection. [15] This results in remission in about 80% of cases. [15] Prognosis [ edit ] The prognosis of stomach cancer is generally poor, due to the fact the tumour has often metastasised by the time of discovery and the fact that most people with the condition are elderly (median age is between 70 and 75 years) at presentation. [81] The average life expectancy after being diagnosed is around 24 months, and the five-year survival rate for stomach cancer is less than 10 percent. [6] Almost 300 genes are related to outcomes in stomach cancer with both unfavorable genes where high expression related to poor survival and favorable genes where high expression associated with longer survival times. [82] [83] Examples of poor prognosis genes include ITGAV , DUSP1 and P2RX7 . [84] Epidemiology [ edit ] Stomach cancer deaths per million persons in 2012 0–11 12–16 17–24 25–33 34–51 52–76 77–102 103–128 129–175 176–400 Worldwide, stomach cancer is the fifth most-common cancer with 952,000 cases diagnosed in 2012. [16] It is more common both in men and in developing countries. [85] [86] In 2012, it represented 8.5% of cancer cases in men, making it the fourth most-common cancer in men. [87] Also in 2012, the number of deaths was 700,000 having decreased slightly from 774,000 in 1990, making it the third-leading cause of cancer-related death (after lung cancer and liver cancer ). [88] [89] Less than 5% of stomach cancers occur in people under 40 years of age with 81.1% of that 5% in the age-group of 30 to 39 and 18.9% in the age-group of 20 to 29. [90] In 2014, stomach cancer resulted in 0.61% of deaths (13,303 cases) in the U.S. [91] In China, stomach cancer accounted for 3.56% of all deaths (324,439 cases). [92] The highest rate of stomach cancer was in Mongolia , at 28 cases per 100,000 people. [93] In the United Kingdom, stomach cancer is the fifteenth most-common cancer (around 7,100 people were diagnosed with stomach cancer in 2011), and it is the tenth most-common cause of cancer-related deaths (around 4,800 people died in 2012). [94] Incidence and mortality rates of gastric cancer vary greatly in Africa. ... "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010" .
Concussions In Sport Wikipedia

He gets back in the game and back to his teammates.” [30] According to Johns Hopkins University , a study took place which “researchers recruited nine former NFL players who retired decades ago and who ranged in age from 57 to 74. The men had played a variety of positions and self-reported a wide range of concussions, varying from none for a running back to 40 for a defensive tackle." [31] Ice Hockey [ edit ] Ice hockey has also been known to have concussions inflict numerous players. ... The difference is found mainly in competition activity compared to practice. [53] National Basketball Association's concussion policy [ edit ] On December 12, 2011, the National Basketball Association (NBA) announced that the establishment of a concussions policy for league. [54] The players and staff are required annual education on topics surrounding concussion during play, including mechanisms of injury, signs, symptoms and interventions. [55] The policies surrounding concussion management in NBA are as follows: If concussion is suspected, the injured player is removed from the game immediately and monitored to ensure safety. [55] At this time, a neurological exam is conducted by the team's physician or athletic trainer. [55] For the following 24 hours after the primary evaluation, the player is monitored closely by the team's medical staff, so long as they are not diagnosed with a concussion. [55] The player must complete at least one other evaluation before the following game or practice (whichever comes first). [55] If the player is diagnosed with a concussion, they are prohibited from participating (on the same day or the next day) and must undergo the requried return-to-participation protocol. [55] The player, under direction of the team's medical staff, must avoid physical exertion and exposure to electronic devices, so as not to aggravate symptoms. [55] Physical activity must be reintroduced gradually according to the medical staff's discretion. [55] A physician must provide an impression regarding the presence or absence of concussion within 24 hours of the incident. [55] In addition, the Director of the NBA Concussion Program must be informed about the concussion evaluation. [55] Combat sports [ edit ] Boxing [ edit ] Despite boxing 's violent nature, a National Safety Council report in 1996 ranked amateur boxing as the safest contact sport in America. [ citation needed ] However, concussions are one of the most serious injuries that can occur from boxing, and in an 80-year span from 1918 to 1998, there were 659 boxers who died from brain injury. [56] Incidence rates for concussion in boxing may frequently be miscalculated due to the fact that concussions do not always result from a knockout blow. [57] Olympic boxers deliver punches with high impact velocity but lower HIC and translational acceleration than in football impacts because of a lower effective punch mass. ... It was first launched in 2007, with aims to improve concussion identification and management. [89] The online tool is available on CDC's website and has been used by 2 million individuals to date. [90] The online resource was updated in 2016 and an interventional study conducted an assessment of the efficacy of the updated version. [89] A systematic review investigated the effects of policies on preventing sports injuries of children at school (ages 4–18) including 26 policies, 14 of which were from the US, and 10 of which were concussion-specific . ... Further research into the effectiveness of guidance for schools on concussion prevention is needed. [91] A systematic review conducted by the Social Science Research Unit in London in 2007 concluded that athletic injuries for young people (ages 12–24) are reduced under supervision by a coach, however strong evidence for interventions to reduce sports-related injuries remains lacking. [92] As such, the authors endorse the establishment of a national sports injury database in order to strengthen the base of evidence for interventions. ... The American documentary series Frontline covered the topic in two episodes, one based on the book and also called " League of Denial ", [98] and the other called "Football High" [99] Political sports journalist Dave Zirin has also covered the topic in detail. [100] Policies summary [ edit ] Policies by major professional sports league [ edit ] League Year policy first introduced Year baseline testing occurred Year current policy became effective First step after injury Person who approves/denies player to return Person who decides player return NFL 2007 2008 2009 Evaluation by medical team Medical staff Medical staff/Consultant MLB 2007 2011 2007 Evaluation by an athletic trainer using National Association Guidelines Medical staff Head physician/Medical director NBA Never Never Never Depends on team Depends on team Depends on team NHL 1997 1997 2011 Neuropsychological evaluation by team doctor off rink Team doctor Team doctor MLS 2011 2003 2011 Evaluation by medical team Team physician Team physician/Neuropsychologist NASCAR 2003 2003 2003 Ambulance to infield care center NASCAR NASCAR See also [ edit ] Sports portal Philosophy portal Concussions in Australian sport Concussion grading systems Head injury criterion Shock data logger Impact sensor Sports-related traumatic brain injury Concussions in high school sports References [ edit ] ^ McCrory, P.; Feddermann-Demont, P.; Dvořák, J.; al, et (2017).
Global Developmental Delay Wikipedia

Umbrella term used when children are significantly delayed in their cognitive and physical development Global developmental delay is an umbrella term used when children are significantly delayed in their cognitive and physical development. It can be diagnosed when a child is delayed in one or more milestones, categorised into motor skills , speech , cognitive skills, and social and emotional development. [1] There is usually a specific condition which causes this delay, such as Fragile X syndrome or other chromosomal abnormalities . However, it is sometimes difficult to identify this underlying condition. [2] Other terms associated with this condition are failure to thrive (which focuses on lack of weight gain and physical development), intellectual disability (which focuses on intellectual deficits and the changes they cause to development) and developmental disability (which can refer to both intellectual and physical disability altering development). Contents 1 Causes 2 Investigation 3 Management 4 References Causes [ edit ] Developmental delay can be caused by learning disabilities , in which case the delay can usually be overcome with time and support - such as with physiotherapists, occupational therapists, and speech and language therapists. [3] Other causes which may cause a permanent delay in development include genetic disorders such as Down syndrome and Fragile X , childhood infections such as meningitis or encephalitis, and metabolic disorders such as hypothyroidism . Metabolic disorders are more likely to cause delayed development in older children as many congenital metabolic problems which are easily managed are screened for in the neonatal period.

SPTBN2, SLC2A1, IGF1R, COL4A1, SZT2, STAG2, GNB1, TRAF7, RAC1, TCF20, SOX4, APC2, KDM5C, KDM1A, KMT2E, ZMIZ1, SMARCC2, PPP2CA, ATN1, ACTL6B, CACNA1B, PIGP, BMP4, AP4S1, PNPO, GPAA1, TSEN15, DEGS1, DIAPH1, SLC25A12, KARS1, PHACTR1, ZBTB18, TRIT1, PIGQ, CHD3, P4HTM, GTPBP2, TAF1, TBC1D20, PIBF1, DHPS, PACS2, FCSK, STT3A, DDC, STT3B, ABAT, CACNA2D2, RARS1, SUZ12, PCGF2, UBTF, TMEM94, TRIM8, FRMPD4, RHOBTB2, LNPK, MAPK8IP3, PUS3, SPART, ZNF142, ALKBH8, CNOT1, TRPM3, TRMT1, BRSK2, VPS53, TRRAP, ZNF462, NBAS, NTNG2, AGO1, RNF13, SMARCD1, POLR2A, GLRA1, SUPT16H, PCYT2, ODC1, SNX27, RALA, KDM3B, OXR1, GABRA5, MN1, GABRA2, DLL1, VAMP2, TRAPPC12, ZNF335, NKAP, SLC5A6, WDR37, PIGU, NSF, GOT2, TMX2, KAT8, FBXW11, RAB11A, PNPT1, HK1, DDX6, CSDE1, UGP2, NFIB, CTNNA2, NBEA, FAM160B1, CDK8, PIGB, CACNA1E, POU3F3, LSS, PRR12, SCAMP5, INTS1, MAB21L1, NUDT2, CDH2, IQSEC1, TET3, PUM1, AP1B1, TKFC, LGI4, HNRNPR, AP2M1, CCDC47, GTF3C3, TAOK1, ACTL6A, FMR1, MECP2, CDKL5, PTEN, KCNJ11, WDR45, TRNT1, ARX, STXBP1, FOXG1, NAA10, YWHAE, DPH1, SLC13A5, SOX5, DYRK1A, DMD, UBE3A, PAFAH1B1, NSD1, PLP1, NGLY1, ASXL3, NALCN, GABRB3, SH2B1, TWIST1, PUF60, WWOX, KCNB1, AUTS2, CACNA1A, ANKRD11, PAX6, KAT6A, NSD2, KCNQ2, BCAP31, DICER1, GNAO1, ACTB, HNRNPU, PCDH19, SOX3, NDN, MED13L, ADSL, IQSEC2, TUBB2A, SMC1A, SATB2, USP9X, SHANK3, SCN8A, KMT2A, ARID1B, TENM3, FGFR3, MID1, TASP1, HRAS, KIF1A, EXOC6B, NR2F1, CTNNB1, CDC42, LIG4, SLC1A4, SLC9A6, MAGEL2, TCF4, TUBB3, LRP5, PDP1, DOCK3, BRCA2, EBF3, HERC2, CHRNA7, PNKP, SIM1, PPM1D, PIK3CA, KAT6B, ATAD3A, VARS1, SLC17A5, MTHFR, TBC1D24, ASH1L, GRIN1, SLC12A5, RARS2, OPHN1, KCNH1, GRIN2B, KCNQ1, MTO1, SMG9, FBXL4, KIF11, GRID2, NDUFA1, SDHD, NIPBL, DNAJC12, ABCC8, AHDC1, CAMTA1, ALDH6A1, VRK1, KCNQ3, GP1BB, PACS1, ZC4H2, FBXL3, NDST1, GRIN2D, HIVEP2, LEMD3, FTO, HECW2, VPS11, ALG9, MAG, SLC25A22, MDH2, HNRNPH2, MACF1, TBL1XR1, NKX2-1, MLYCD, TP53, TRPS1, INSR, SOX2, OCRL, TCF12, NAA15, RAB3GAP2, TBX1, SETD2, SON, SOS1, PGAP2, SLC35A2, NEDD4L, NTRK2, NF1, MEIS2, UPF3B, NFIA, PCDH15, PGAP1, GRIK2, GLS, PIK3CD, SPATA5, ARFGEF2, VPS13B, PMM2, POMT1, CLTC, AHI1, EBP, RPE65, AP1S2, PIK3R2, RAI1, KDM5B, TANGO2, CRX, CASK, CSNK2A1, BCOR, CTBP1, CUX1, CYP27A1, GLI3, DHCR7, MSMO1, CYB5R3, TWIST2, PEPD, DNM1, KPTN, DPYD, POLG, ARID2, CAD, CRBN, HDAC4, PTPN11, PHF21A, ACY1, PTCH1, LARP7, ADK, AKT1, KIF14, QARS1, AMMECR1, IYD, PRPS1, SCO2, DNM1L, MAP2K2, UPB1, ATG5, EIF2AK3, RAF1, PPP3CA, BCL11A, ATRX, UNC80, EFTUD2, GPHN, ASPM, BTD, CA2, C12orf57, PIGA, ECHS1, PAK1, UBE3B, FANCD2, ACSL4, BPTF, CWF19L1, SLC35C1, WDR73, DHX30, FOXRED1, KMT2D, PDHX, PARN, PIGO, TUSC3, EYA1, ALDH5A1, TUBA1A, MOGS, ZNF148, LRRC32, GATA4, EMC1, OTX2, ZIC1, OTC, POGZ, TRAPPC9, KDM6B, SLC25A46, FGFR2, EXTL3, CUL4B, TBCK, EFNB1, EEF1A2, SCN1A, B4GALT7, SCN2A, MARS2, COLQ, EXT2, EPRS1, SEPSECS, TBC1D7, TMEM216, PCLO, GEMIN4, SLC45A1, DUOX2, PCDH12, POLR1D, OSTM1, GMPPA, TIMMDC1, NDUFA13, GMPPB, DCPS, PAM16, NPHP3, GMNN, KCNK9, PSAT1, POMT2, RSRC1, ALG6, CCDC174, EXOSC3, PYCR2, CCDC22, DIMT1, KMT5B, SBDS, MMADHC, TPRKB, UBE2T, ASCC1, NFU1, CDON, IER3IP1, CYFIP2, NDUFAF4, INVS, ABHD5, RLIM, RDH11, AFF4, NIN, NDUFAF1, ZBTB11, TACO1, UQCRQ, B9D1, MECR, MRPS2, NSDHL, TUBGCP4, AARS1, RPS6KC1, MAD2L2, ZMYND11, KIF1C, PLK4, YME1L1, AP4B1, TBR1, GNB5, FARS2, CTCF, MTHFS, NPC2, SLC35A1, RNASEH2A, DEAF1, CIB2, WDR4, SDCCAG8, CPLX1, B4GAT1, PLPBP, CORO1A, IL1RAPL1, POLR3A, CIT, MID2, VAX1, PDE10A, TLK2, SPINK5, MAPRE2, CLP1, MAGED2, SRCAP, SEC23B, TUBB4A, MAN1B1, MICU1, GNE, AKT3, SLC12A6, MED12, MAFB, ARNT2, AP5Z1, WASHC5, FIG4, TECPR2, TELO2, SEC24D, RUSC2, KIAA0753, ZBTB24, HUWE1, USH1C, PQBP1, COQ7, WARS2, RXYLT1, KATNB1, TRAIP, STAG1, STUB1, CD96, CERT1, ALG3, SLC25A15, SLC25A13, LRPPRC, MKRN3-AS1, TSFM, MRPL3, TREX1, TINF2, CRB1, CIZ1, FTSJ1, AIPL1, NPAP1, FRRS1L, ORC6, PIGN, CDK20, ATP6V0A2, SLC39A14, HAAO, TGDS, ETHE1, SLC35A3, GPR161, TXN2, COG4, NDUFAF3, CNTNAP2, VPS33B, HIBCH, TRAF3IP1, KIFBP, TCTN3, WIPI2, C2CD3, PTPN23, AAR2, NECAP1, MMACHC, PARS2, SIN3A, SAMHD1, AP4E1, ADNP, EXOSC8, SIK3, ZNF292, CEP152, MAST1, NT5C2, RPIA, RAB18, RAB3GAP1, TRAK1, CEP164, MORC2, FASTKD2, CNKSR2, CHSY1, MRAS, COG2, MYT1L, TNIK, CLUAP1, SPG21, SPECC1L, CLASP1, WASHC4, RPGRIP1L, CUX2, NCAPD3, AGTPBP1, ZNF423, DDHD2, KIAA0556, PMPCA, CIC, ANKLE2, NFASC, WAC, LMBRD1, MBTPS2, TP53RK, CEP41, PIGS, ST7-AS2, PGAP3, TIMM50, GORAB, STRADA, MTSS2, NDUFAF2, RFT1, ATPAF2, C12orf65, TMEM67, LYRM7, ERI1, HS6ST2, LHX4, DOCK7, TUBGCP6, TUBA3E, NACC1, ATCAY, CHST14, WDR81, USH1G, METTL23, EARS2, MTFMT, TTC8, ISCA2, TRAPPC6B, ARL14EP, BORCS5, RAB39B, COX20, NUS1, FOXP4, SLC25A26, NLRP3, TOE1, CYP2U1, SLC46A1, ALG2, USP45, HIKESHI, TMEM107, PHF6, UTP23, POMK, FAR1, KIAA1109, RNASEH2C, MAGT1, BRIP1, CDCA7, ITCH, JAM3, C19orf12, TMEM47, LAS1L, MED25, ISCA1, CDT1, CLPB, LMAN2L, UQCC2, CCDC115, PIGY, COA8, COX14, SERAC1, TMEM87B, ATAD1, LINGO1, POMGNT2, MFSD2A, LMNB2, GPT2, GTPBP3, COX4I2, SLC9A7, KDM2B, FAM126A, COL25A1, NKX6-2, SLX4, COG8, GFM2, MICOS13, NDUFA11, B3GALT6, NHLRC2, HCN1, TUBB2B, ZNF81, ZFP57, KCNT2, RD3, FREM2, HEPHL1, NEXMIF, SLC6A19, NAT8L, TMEM240, FLG-AS1, SNORD115-1, MMAB, FAM149B1, SUMF1, WDR62, PIGW, NDUFS7, KIF7, DMBX1, SLC6A17, SNHG14, SCN1A-AS1, NPHP3-ACAD11, OCLN, RNU4ATAC, KLLN, PET100, SNORD116-1, PWRN1, UQCC3, CRPPA, D2HGDH, SNORD118, ALG11, DUOXA2, GTF2H5, GDF6, USP27X, BOLA3, KANSL1, TSEN54, CHAMP1, H19, CEP120, CKAP2L, SIK1, B3GALNT2, PWAR1, RDH12, B3GLCT, PTCHD1, AMER1, HGSNAT, NDUFAF6, VPS37A, MPLKIP, CD109, DNAJC21, NADK2, GLYCTK, DIS3L2, PROKR2, ESCO2, TMTC3, NAGS, ARL13B, NPHP4, MFSD8, SYT14, BRAT1, JMJD1C, HYLS1, TUBB, FLCN, ACSF3, TMEM92, POLR3H, ASXL1, GLIS3, BMPER, LCA5, MMAA, RNF168, SASS6, SLC2A10, SLC19A3, COASY, TMEM126B, CENPJ, SPATA7, KIAA0586, MCTP2, ERMARD, TBC1D23, CDK5RAP2, NUP133, WDR11, CCDC88A, POLR3B, IARS2, VAC14, FRMD4A, PEX26, NHP2, PIGV, OSGEP, FLVCR2, TMEM165, HDAC8, SCYL1, NDUFA12, SNX14, MCOLN1, SELENON, GJC2, NUP107, C12orf4, RPGRIP1, KNL1, HYMAI, COQ9, FAM20C, MFF, MCCC1, FMN2, TWNK, INPP5E, KCNQ5, ALG1, KLHL7, CHD7, POMGNT1, DHTKD1, NOP10, LZTFL1, NDUFB11, PUS7, TMCO1, PRMT7, GPR88, FGFRL1, TUBA8, INPP5K, RTEL1, SUFU, ZFR, MPC1, PTRH2, OTUD6B, PIGT, LIPT1, TMEM138, LARS1, CNNM2, DYM, SAMD9, FANCL, MAP11, ASXL2, ELP2, FANCI, SETD5, LINS1, RFWD3, WRAP53, SOBP, NDE1, PHIP, RMND1, TMEM70, MKS1, NCAPG2, NSUN2, PIGG, CC2D1A, KAT14, GATAD2B, KLHL15, NARS2, COLGALT1, USB1, MCPH1, SRD5A3, ROGDI, FAT4, EFL1, RNASEH2B, TCTN1, CEP97, CARS2, TMEM231, THOC6, GNPTAB, FKRP, MBOAT7, CCDC28B, NDUFAF5, ALG12, PALB2, SNIP1, SHROOM4, FBXO31, CEP63, WDR26, NUBPL, TARS2, ARMC9, FBXO11, TTI2, CEP290, CTC1, EDC3, PANK2, DHDDS, ZC3H14, UBA5, ALG13, TCTN2, CSPP1, CAMKMT, EHMT1, COLEC11, MRPS34, CPLANE1, RSRC2, BCORL1, TRAPPC11, ALX4, ELAC2, MPP4, KMT2C, NLRC4, SPTBN4, WDR19, EPG5, FANCM, ZSWIM6, DOCK6, TRMT5, CC2D2A, HACE1, ARHGAP31, COG6, KIDINS220, VIPAS39, PIEZO2, FAM111A, NXN, VPS33A, TMEM237, ACD, BCL11B, PLEKHG2, NMNAT1, ARV1, SIL1, IRF2BPL, MRPS14, P3H1, IFIH1, XYLT1, SLC39A8, MCCC2, CDH23, PRDM16, CXorf56, PTDSS1, RAB11B, PIEZO1, KIF5C, LHX1, LETM1, LBR, LAMP2, LAMB2, AFF3, KRAS, KIF22, KIF5B, TRNS1, KIF2A, KCNMA1, KCNJ13, KCNJ10, KCNJ1, KCNC3, KCNA2, KCNA1, LIPA, LMNA, LMNB1, LRP2, MTRR, MTR, ND3, ND2, ND1, ATP6, MPV17, MLLT1, MIPEP, MGP, MGAT2, MEFV, MCM4, MARS1, MAN2B1, SMAD4, LTC4S, IVD, ITPR1, ITPA, HLCS, HELLS, HTT, HCFC1, HCCS, HADHB, HADHA, HSD17B10, H3-3A, H1-4, GUCY2D, GYS2, BRF1, GTF2E2, GRM7, GRM1, GRIA4, GRIA3, MNX1, HMGB3, ITGB3, HNF4A, ITGA2B, ITGA2, IREB2, IPW, PDX1, INS, IMPDH1, IGF2, IDUA, IDH2, IARS1, HTC2, HSPD1, HSD17B4, HPRT1, HNRNPK, HNMT, TRNN, MMUT, GNAI3, PDHA1, PGK1, PEX14, PEX13, PEX12, PEX10, PEX6, PEX1, SLC26A4, PDE6D, MVK, PDE4D, PCYT1A, CHMP1A, PCNT, PCNA, PCK1, PCCB, PCCA, PGM3, PIGC, PIK3C2A, PLAGL1, MAP2K1, MAPK1, PRKD1, PRKAR1A, PRF1, PPT1, PPP2R5D, PPP2R1A, PPP1CB, PPM1B, POU3F4, POU1F1, POLA1, EXOSC9, PLG, PLEC, PLCB4, PC, PAX1, PAK3, NDUFS6, NDUFV1, NDUFS3, NDUFS2, NDUFS1, NDUFB10, NDUFB9, NDUFB8, NDUFB3, NDUFA10, NDUFA9, NDUFA6, NDUFA4, NDUFA2, NAGA, MYO7A, MYO5B, MYO5A, NDUFS4, NDUFS8, PAH, NDUFV2, PRDX1, P4HB, ORC4, ORC1, SIX6, OPA1, OGDH, DDR2, ROR2, NTRK1, NPHP1, NPC1, NOTCH3, NFKB2, NFE2L2, NEUROD2, NEK1, GP1BA, GM2A, PRODH, CAMK2A, CDH11, CDC6, CCND2, CBS, CBL, CAPN3, CAMK2G, CAMK2B, SLC25A20, CRKL, CACNA1D, CACNA1C, CA8, BUB1B, BUB1, BRAF, BRCA1, BMP2, CDK5, CDK6, CHD1, CHD2, CPS1, COX15, COX10, COX8A, COX7B, COX6B1, COMT, COL6A3, COL6A1, COL4A2, COL3A1, TPP1, CLIC2, CLCN4, AP1S1, LYST, CHN1, BCS1L, BCR, BBS2, ARG1, AQP2, APP, ANK1, AMPD2, AHCY, AGTR2, ADD3, ADAR, ACTG1, ACTA1, ACOX1, ACO2, ACAT2, ACADSB, ACADS, ACADM, ABCB7, ABCC6, ARL3, BBS1, STS, AVPR2, AUH, ATP7A, ATP6V1E1, ATP6V1A, ATP5F1D, ALDH7A1, ATP2B3, ATP1A3, ATP1A1, RERE, ASS1, ASPA, ASL, ASAH1, ARVCF, ARSL, CREBBP, CSTB, GLUD1, FLNA, GABRB1, GABRA1, FZD2, FUT8, FUCA1, MTOR, FRA16E, FLNB, FLII, NKX2-5, FLI1, FLG, FOXE1, FOXE3, FH, FGFR1, FGF12, GPC4, GABRB2, GABRD, GABRG2, GAD1, GLI2, GCLC, GPC3, GK, GJB2, B4GALT1, GFER, GDI1, GCK, GCH1, GCDH, GBA, GATM, GATA6, GAMT, GALE, GALC, FKTN, FBN1, FANCG, DVL3, DPAGT1, DNMT3B, DYNC1I2, DYNC1H1, DNA2, SARDH, DLG3, DLD, DLAT, DKC1, DHFR, DHCR24, DDX11, DDX3X, DDOST, DCC, DAG1, DVL1, EDN1, FANCF, EDNRB, FANCB, FANCE, FANCC, FANCA, EZH2, ERCC5, ERCC4, ERCC3, ERCC2, ERCC1, EP300, EML1, EIF2S3, MEGF8, CELSR2, EGF, PHC1, PROC, NFIX, PROP1, UCP2, TAF13, TALDO1, TBCD, TBCE, TBX2, HNF1B, CTDP1, TCOF1, AIFM1, SMC3, TERC, TERT, ASH2L, TFAP2B, TG, TGFB1, TSPAN7, TPI1, TPO, PLOD3, TRHR, TRIO, TSC1, TSC2, KYNU, TSHR, TTPA, TUBG1, TULP1, TAF6, TAF2, SYT1, SNRPN, TRIP12, TRIP13, SMARCA4, SMARCB1, SMARCE1, SMO, SMPD1, ADGRG1, COPB2, AIMP1, LRAT, LARGE1, SNAP25, SOX10, SYP, SOX11, SLC33A1, SPR, BUB3, SRP54, SSR4, STAT3, ELOVL4, STIM1, STX3, SUOX, SURF1, FIBP, HIRA, UFD1, SMARCA2, HERC1, PEX11B, LHX3, TNFRSF11A, AAAS, HMGA2, AP3B2, MKKS, CHAF1B, LZTR1, SYN3, MATN4, RBM10, LAGE3, ARID1A, ACOX2, CDC45, PLA2G6, LTBP4, OGT, CRADD, OFD1, PRSS12, PEX3, KCNAB2, IKBKG, CDK10, CDK13, EED, DCHS1, NUP214, ST7, SUCLG1, HESX1, CACNA1G, UMPS, KDM6A, SGPL1, ST3GAL5, EZR, VLDLR, SYNJ1, WFS1, WHCR, NELFA, SYNGAP1, WNT5A, XRCC2, SUCLA2, XRCC4, YY1, YWHAG, ZIC2, ZNF711, ZNF41, MKRN3, RNF113A, DPM2, ALMS1, PAX8, BRPF1, CCNK, TRIP4, AP4M1, ATXN7, MPDU1, RORB, SET, RORA, ARHGEF6, MED17, ROBO1, RET, SGSH, SHH, DPF2, ST3GAL3, STIL, RBBP8, TTC37, SIX1, SIX3, MED23, RAD51C, RAD51, SEC24C, SDHC, RPL10, SC5D, SCO1, SCN9A, TECR, PREPL, SCN3A, SDHA, PMPCB, SCN1B, SARS1, PIGL, NCOR1, RYR1, CLIP1, RREB1, RPS28, RPS6KA3, RPL35A, SDHB, IQCB1, PEX16, SKI, PSMD12, SLC6A8, SLC6A9, PURA, PLAA, PTS, IFT140, EIF4A3, PSPH, LONP1, SEMA3E, PSAP, SLC12A1, RELN, SLC16A1, SNAP29, SLC18A2, SLC25A1, ZNHIT3, SKIV2L, CEP104, ADAMTSL2, PYCR1, COG1, RAD21, SLC1A2, SLC2A2, QDPR, CEP135, SLC6A3, ALDH18A1, PEX5, PEX2, SLC3A1, CEP57, PEX19, RUBCN, SLC5A5, SLC6A1, POLR1C, NRXN1, FOXP1, ARSD, FOXP2, CHD8, BDNF, MEF2C, CMIP, FBN2, IGF1, MAPT, GRIN2A, POU3F2, MBD5, UROD, SETBP1, IFNG, PHGDH, HAX1, ZBTB20, PCDH8, PMP22, GLRB, CNTN6, CDKN2A, GABARAP, CSNK2B, FRAXA, TARDBP, RUNX1, KIF1B, ATP8A2, SLC4A4, FRAXE, PIGH, SIRT6, DRD3, PNP, QRICH1, ABCD1, MIR484, TUBGCP2, BAIAP2, BHLHA9, TNFRSF10C, CAT, PAPOLA, AVP, GREB1, MFN2, APOBEC3F, SUB1, CKAP4, CLCN7, SV2A, TUBGCP5, PAXBP1, H3P8, SGMS1, TOR1A, RPP14, RIPK1, ARID3A, MTCO2P12, BTG1, COPS2, RALGAPA1, AZIN2, KMT2B, ADGRB3, HDAC9, DLGAP2, DBX2, SLC9C2, TNFSF13, BANF1, CD28, ALDH1A3, NKAIN2, EIF2B2, MAGED1, NRG3, SGCE, RAB36, CCDC103, RTL1, MBD2, COL4A6, ERCC6L2, DNAJA3, MAD2L1BP, RSS, NRXN2, SH2B3, IRGM, CLCN3, CACUL1, PRICKLE1, CNTN4, GPBAR1, ABCB6, CNTF, HEXIM1, PAPSS1, DSG4, EDIL3, ARHGEF7, CP, PPP1R21, CAPN10, PIANP, FRY, AGO3, TAF1A, GADL1, CD38, APOE, DCR, CD44, DGKB, SLC6A5, SYNCRIP, CYP21A2, CTSL, NLRP5, CDH12, STK25, HBS1L, CDK5R1, CDKN1B, CRY2, CENPE, CBFA2T2, RAI2, CDK2AP2, UVRAG, CADPS2, NUFIP1, SNAI2, AS3MT, SLC16A2, VARS2, SALL4, MUC1, DISC1, NBN, HPGDS, RETN, SKP1, LAMTOR2, MEPCE, MRPS28, SHOX, SETMAR, NELL2, COX2, VCX, NGF, NLN, SPTBN1, KRT10, SPOCK1, SPAST, SPARC, SOX12, SOX9, TACSTD2, SMS, MAOA, LRRC4C, MAOB, KIF17, MBP, MC1R, MC4R, SACS, KEAP1, NHS, ABCB11, CEND1, RAC3, PIK3CB, PIK3CG, PIK3R1, PITX2, PPP1R12C, RBFOX1, SEPTIN5, UGT1A1, PVALB, POMC, DDX41, NANS, PTGS2, PTH, PSEN1, SF3B6, TTC19, ADPRS, CNOT2, THG1L, SMARCAL1, CXCL6, NTF3, CCL11, CCL2, NTM, OPCML, SCN7A, NLRP2, ATXN2, SERPINE1, S100A9, PAX2, RYR2, PDE1C, BRD2, RB1, KCNJ6, KCNJ3, KCNC1, FUT4, ELOF1, ZBED3, XIST, ZIC4, ZRANB3, WNT1, LRMDA, WDR87, FBXO28, GH1, GHRH, WARS1, VWF, TRPV1, GLUD2, VEGFA, GMDS, USP7, SEM1, CIAO3, NR5A1, TP63, KLF7, ADAMTS6, EPHA7, ERBB4, ESRRG, F5, FABP3, UBL7, PNPLA4, FOXC1, PARP10, CUBN, AFF2, FOLH1, CAPS2, KISS1R, PRL, GNB2, GOLGA2, GOLGA4, MMD, IDS, IFN1@, IL1B, IL2RA, IL6, DERL1, IL6R, CXCL8, PRRG4, ALG8, GSPT2, TBX5, ISG20, NBEAL1, ITGB2, CSMD1, HSPA4, TGFBR2, POFUT1, L2HGDH, GPD2, GRIK3, GRIK4, OPA3, UBE2A, PPP1R13B, NRSN2, RHOQ, HOXC@, HDAC2, NRG1, TOP2B, HEY2, THRA, HOXA13, HOXB@, H3P10
Sports-Related Traumatic Brain Injury Wikipedia

The SAC and SCAT-2 evaluations also contain symptoms checklists which can determine immediate cognitive and motor deficits, although many symptoms may present hours after the initial injury. 85% of certified athletic trainers use symptom checklists as part of a concussion assessment according to a recent survey. [9] Limited research of the test since its release from the Zurich Concussion statement has not allowed it to be verified as a successful testing method. [6] The SAC however, does have sufficient evidence regarding its reliability, with researchers finding the test having a test-retest reliability of 53%. [9] Many major professional sports organizations like the NFL, NHL, MLB and NBA have taken stronger looks at in game concussions through extensive studies to develop safer equipment and playing conditions for the players. ... Lastly, the leagues medical director must clear all players who have suffered a concussion before they can return to play. [13] Of the four major professional sports in the U.S., the NBA is the only league to have not adopted a sideline concussion policy. ... The highest rates of contusions occur in men between the ages of 15 to 24, somewhat due to their aggressive nature. [21] If a person sustains a contusion one time, they are more likely to sustain a repeated one. [22] (see cerebral contusion for more information) Signs and symptoms in sports [ edit ] In the heat of a game, it may be hard to see or feel symptoms relating to cerebral contusions. ... Factors such as elevated intracranial pressure, increased patients age, and abnormal GCS results lead to a poor prognosis.
Situs Inversus Wikipedia

He supposedly had his appendicitis originally misdiagnosed due to his reversed organs. [12] However, he told Penn Jillette that he does not have this condition, and that the story originated from an out of place appendix. [ citation needed ] Randy Foye , an American basketball player in the NBA . He has suffered no discernible complications, and the condition is not expected to affect his career as a professional athlete, as all his organs are in reverse. [13] Ginggaew Lorsoongnern , a Thai convict executed by firing squad.

CFAP53, NODAL, PKD1L1, DNAH9, CITED2, ACVR2B, NME7, MMP21, ANKS3, CFAP52, ANKS6, ZIC3, NPHP3, CFC1, ACTG2, LETM1, NSD2, NPHP3-ACAD11, NELFA, DNAH7, TNF, CCR5, ITIH4, HLA-C, IFNA1, PTPN11, IFNA13, IVNS1ABP, INVS, DNAH11, IL7, IL15, CXCR6, MNS1, CXCL10, TBX1, IFNB1, CCDC151, WAS, TRBV20OR9-2, IL10, CXCR4, HLA-B, IFITM3, DNM1L, CCL4L2, TNFSF13B, CH25H, PDLIM7, SIRT1, LRRC6, SH3BP4, ARTN, SDS, ACTB, DNAI1, IL37, CD24, CALHM6, EIF2AK4, MIR212, MIR206, MIR150, MIR130A, CCL4L1, DNAAF3, RSPH9, ENKUR, PIFO, MUC16, TRIM5, HAVCR2, MAVS, ACSS2, ARMC4, LZTFL1, CDON, IL21R, CD274, SESN1, RIPK1, SPP1, KMO, MADCAM1, IFN1@, HNF4A, GZMB, GDF1, GCK, FOXJ1, FCGR3B, FCGR3A, F3, DPP4, CDO1, CD58, CD80, CD28, CD4, CD247, CASP1, CXCR5, BCL6, BCL2, ATF4, APP, ANXA5, NR0B1, AGRP, IFNAR2, IL1B, IL2, PKD2, ZFP36, TLR4, SP1, SIGLEC1, SHH, CCL5, CCL4, CCL3, PRKCSH, PPARA, PMP22, OPRM1, IL6, NPR2, MRC1, MPZ, MPL, LTB, KLRC2, KLRC1, KIR2DL4, IRAK1, IL18, IL17A, LINC02605
- Situs Inversus GARD
  
  Situs inversus is a condition in which the arrangement of the internal organs is a mirror image of normal anatomy. It can occur alone (isolated, with no other abnormalities or conditions) or it can occur as part of a syndrome with various other defects. Congenital heart defects are present in about 5-10% of affected people. The underlying cause and genetics of situs inversus are complex. Familial cases have been reported.
- Situs Inversus Totalis Orphanet
  
  A rare, genetic, developmental defect during embryogenesis characterized by total mirror-image transposition of both thoracic and abdominal viscera across the left-right axis of the body. Congenital abnormalities, such as primary ciliary dyskinesia, Kartagener type, polysplenia syndrome, biliary atresia, congenital heart disease, and midgut malrotation, as well as vascular anomalies (e.g. absence of retrohepatic inferior vena cava, preduodenal portal vein, aberrant hepatic arterial anatomy) and malignancy, are frequently associated.
Primary Immunodeficiency Wikipedia

Most primary immunodeficiencies are genetic disorders ; the majority are diagnosed in children under the age of one, although milder forms may not be recognized until adulthood. ... Other problems become apparent due to aging of bodily and cellular maintenance processes.

DNMT3B, ATM, CD3E, EPG5, FCN3, CD36, ZAP70, C4A, C9, C8B, C8A, C5, C3, CHD7, MAGT1, MYSM1, C1QB, CFH, BLM, CACNA1C, NBAS, CFD, RASGRP1, LEPR, RAG1, RAG2, CD19, CD40LG, TERT, PIK3CD, GATA2, MYC, MAPK1, CTLA4, STAT1, BTK, LRBA, CD28, WAS, TGFB1, CAV1, CYBB, XIAP, MS4A1, ORAI1, SH2D1A, IL21, ACTB, NFKB2, IRF7, IKBKG, LAMTOR2, PGM3, CD40, IL2RA, AICDA, BCL10, PPARG, MALT1, NHEJ1, SP110, IRF8, RAB27A, RAC2, CARD11, CD247, CTPS1, STIM1, DCTN4, TFRC, IL12RB1, POMP, TNFRSF13B, IRAK4, LYST, MYD88, TNFRSF4, XRCC4, ICOS, TYK2, BCR, IKBKB, CORO1A, IL2RB, PIK3R1, RNF168, HBB, FOXN1, CXCR4, MMUT, CUL4B, MYH7, FCGR3A, NSD2, TTC37, TNFSF12, DOCK2, AGPAT2, HYOU1, IKZF1, LETM1, DKC1, MEIS2, ATN1, AP3D1, ZBTB24, WIPF1, ISG15, LCK, USP8, UNC119, WHCR, IFNGR2, MYOC, IGLL1, STX1A, STK4, CYBA, IL10, PKP1, IL2RG, IL2, SKIV2L, VEGFA, S100B, RREB1, POLE, IGHM, PRPS1, PRKCD, IFNG, TBX1, IL12B, GP1BB, TCF3, UROS, UNG, UFD1, ITIH4, FOS, NCF2, HIRA, TP53, TNFRSF1B, NFE2L2, IFNGR1, NFKB1, TNF, GATA1, PARN, H3P19, SEC24C, CD34, CD79A, JMJD1C, CAVIN1, IRF2BP2, CD3G, CD9, IL21R, ERVW-1, CD79B, BSCL2, CD81, CDC42, CFTR, CHD1, BLNK, NCF1, CCR5, CD3D, MBTPS2, RTEL1, ADA2, ARVCF, ATRX, SHANK3, ACD, CARD9, CDH23, ERVK-6, COG6, LRRC8A, SLC46A1, TNFRSF13C, ANTXR2, NRSN1, FGFRL1, C11orf65, LAT, LMNB2, ADA, COMT, CPLX1, CRKL, CLCA4, SIK3, MYOCOS, TINF2, SIN3A, CTBP1, TMED2, AGL, CR2, CHP1, TPPP, ERVK-20, TAT, CD38, ERVK-32, DMD, IL4, AGRP, PROM1, ARTN, CD274, BCL2, NOG, FOXP3, ERVK-18, ERBB2, STAT3, DOCK8, TRIM5, CD44, SAMHD1, ALB, IL1B, HLA-C, CCL2, PLAU, ABL1, CXCL12, HGF, IL6, IL13, PDCD1, PIK3CA, SOAT1, CSF2, APOBEC3G, PTGS2, APRT, CD68, CCL5, IL22, EPHB2, IFNA1, IFNA13, MFAP1, SOX2, CRP, SPN, DPP4, PIK3CB, PIK3CG, CCR2, PTPRC, NOTCH1, HAVCR2, AKT1, CD24, ITGB2, CXADRP1, MET, LGALS1, CXCL10, MIR34A, IL1A, IL7, IL15, JAK3, MUC1, AIRE, APOBEC3H, KRAS, CXCL8, PRKAR1A, CXADR, ARR3, SPG7, CD47, FN1, MKKS, PGLYRP1, TLR4, PDLIM7, EGFR, GH1, GLB1, NR1I3, CASR, SPP1, CD70, KRT20, SOD1, BST2, COL18A1, CCND1, TRIM13, HLA-A, CTNNB1, CSF3, SOCS3, POU5F1P4, TNFSF13B, KMT2D, CDR3, IGHV3-75, TNFSF10, ABCG2, LIG1, MBL2, MMP13, KMT2A, CIITA, EPCAM, OBP2A, RBM8A, ARL4C, MLYCD, PRKN, POU5F1P3, PNP, POU5F1, PTBP1, RMRP, ACKR3, PLEK, GJB6, TLR9, PIN1, GDE1, IL23A, TRBV20OR9-2, TLR7, TGFBR2, TGM1, THPO, TLR3, MIR15A, DEF6, TP53BP1, TNFSF4, PRKDC, NT5E, NPM1, LDLR, ABCA1, ALK, HLA-B, FGF2, CD69, IL16, AR, GATA3, NR0B1, ICAM1, HLA-DRB1, ANOS1, JAK1, TNFRSF17, IL17A, ITK, HMOX1, IGHG3, BCL6, FLT3, FLT3LG, ITGAL, BCL2L1, ENPEP, HP, ERBB3, CYP2B6, FCN2, IL3, CLU, IGF1, IL4R, HIF1A, LAG3, CCR3, KIF22, F3, BRCA1, EGF, GJA1, LAMC2, KDR, APCS, FASN, DUSP5, KRT19, CEACAM5, TNFRSF8, APOBEC3C, LAMP3, CD14, PDCD4, CD58, CD33, DLL1, CHEK1, SETD2, CD207, CHUK, ERO1A, CD8A, CDH4, TMED7, STMN1, EGFL7, CD4, ROBO4, DLL4, ERCC6L, ESRP1, ALKBH5, CASZ1, MKS1, ZNF654, LARP6, AP1AR, HES6, GPRC5D, C3AR1, NLRP2, POLR3E, CALR, CASP6, CASP8, VTA1, LEF1, CD1C, CCNT1, CCND2, DCDC2, HSD17B7, CBS, IL17D, CBFB, RUNX3, WWOX, RUNX1, RUNX2, BCL11A, CCR6, RASGRP3, ACAD8, HSPH1, DCTN6, NFAT5, GIPC1, NES, KDM5B, CCR9, CX3CR1, CUX1, AHSA1, FRS2, HPSE, RUVBL2, LILRB1, FGL2, PPARGC1A, CTSB, KHDRBS1, TXNRD2, CCR7, CPQ, RABEPK, EFS, LANCL1, DCC, TLR6, KLF2, NDRG1, IFITM3, CXCL13, MERTK, DAP, IPO7, ZNRD2, GLRX3, HTATIP2, CYP21A1P, APOBEC2, CCN2, EBNA1BP2, PDSS1, SMCHD1, CRABP2, SIRT1, COX8A, CRB1, COMP, DDX58, NUP62, IL24, TDP1, BACE2, RNF19A, COL11A2, LTB4R, POLDIP2, CMKLR1, MAN2B2, CLEC16A, MCF2L, ACSBG1, CSF1R, CD160, MAPK14, FSTL1, PSIP1, AKAP13, RNF139, CRYGC, VPS45, CRK, NLRP1, KLRK1, NT5C2, ACIN1, TNIK, HHAT, SALL4, GPRC5C, MIR10A, MIR142, MIR143, MIR150, MIR152, MIR155, ALOX5, MIR182, MIR197, MIR206, MIR21, MIR210, MIR29B1, MIR29B2, MIR302A, LHX8, MIR141, MIRLET7I, MUC20, LINC01194, CT83, ANGPT1, IL27, IFNL3, CLEC9A, AMD1P2, CXCL17, ARMH1, CPP, IRGM, PWAR4, TICAM2, AMD1, CCL4L1, LIN28B, EIF2AK4, MIAT, CALHM6, MIR526B, PARP1, ERVK-22, ADORA2A, ERVK-11, CCR5AS, UPK3B, OLA1P2, RN7SL263P, MTCO2P12, ACVR2B, LOC110806263, ACVR1B, LINC02605, H3P23, H3P28, ERVK-12, ERVK-2, COMMD3-BMI1, POTEF, ALDH1A1, AK2, APLNR, H3P37, MIR657, MIR660, AGT, KLRC4-KLRK1, HOTAIR, GRK2, AD12, TMED7-TICAM2, MICA, RPL17-C18orf32, PRSS55, CRYGEP, MESP1, BMP7, HAMP, PTBP2, BMP2, BMI1, IGAN1, CFB, BDNF, NOD2, ABCG4, ROBO3, BCL11B, RAPH1, MUL1, VTCN1, NANOG, ANKRD36B, MRTFA, APOBEC3F, BMPR1B, CMAS, NSFL1C, MYDGF, PDGFC, BSG, METTL3, CTPS2, RETN, BRAF, AKR1B10, PDXP, DLD, TTC7A, MAVS, MTUS1, SCD5, FBXO11, PDGFD, ADGRB1, NLRP3, APOA1, BIRC3, RBM45, DCBLD2, APOBEC3D, APC, SIRPA, CARMIL2, PRUNE2, CBLL2, APBB1, ANXA6, ANXA1, DEFT1P, APOE, CDCA5, ORAI3, SPZ1, ATF4, ADAMTS12, SLC4A9, FERMT3, ART1, ARSA, RHOH, G6PC3, AQP3, UBASH3B, FAS, KLK3, TSLP, ESAM, MSLN, EDA, EBI3, HSPA4, IGFALS, IFNB1, MAPK8, IFI27, PSMB6, PSMD7, PSMD9, IDH1, PTEN, PTH, PTGS1, ICAM3, PTPN1, PTX3, RAD1, PRKCB, IGFBP2, PRF1, PLG, PIP, PITX1, PITX2, IL3RA, PLD1, PLEC, IL1RN, PPT1, PLK1, PML, RBPJ, PPARA, IGFBP7, PPP2R1A, RAB6A, RAC1, CXCR1, HOXD13, SDC1, HLA-DQB1, SELE, SFTPB, SGCB, ST6GAL1, ST8SIA1, SLC1A2, SLC1A3, SLC3A2, SLC11A1, SLC22A3, SNCA, FSCN1, HBG2, XCL1, HLA-DQB2, CCL4, RBP4, HOXB4, RARA, PLAAT4, RASGRF1, KDM5A, RBP2, HOXA13, CLEC11A, HOXA9, BRD2, RPL17, RPS19, HMGA1, SALL2, IL5, IL9, GZMM, KCNH2, MLLT1, MMP1, MMP2, MMP7, MMP9, KCNMA1, MNAT1, MOV10, MPO, MRC1, CITED1, MSI1, MST1, MST1R, COX2, CD99, KIR2DL2, KIR3DL1, LOX, RPSA, LAMP1, LGALS3, LAMB3, LMNA, LMO2, LRP2, KLRD1, LY6E, MXD1, SMAD7, KRT5, MCL1, MECP2, MTHFD1, MYCL, CXCR2, IVL, OSM, PCSK6, PAEP, SERPINE1, PAK2, TNFRSF9, PAWR, PAX5, PAX6, PDGFB, PECAM1, IL12A, ABCB1, SERPINA1, IL10RA, OPRM1, ROR1, IL18, NFE2, ITPR1, NAP1L1, NBN, ITGB7, DRG1, NF2, ITGAM, NRAS, ISG20, NGFR, IRF3, CCN3, ING1, IDO1, HBG1, SPINK1, ARFRP1, EIF4EBP1, IQGAP1, NRP1, CFLAR, CDK5R1, CDC123, SQSTM1, MCM3AP, EPO, MBD2, EPHB6, F2RL3, EMP1, PKD2L1, ELN, ANGPTL1, IL18R1, TNFRSF10D, FADD, EIF3D, EWSR1, HAT1, APOL1, ETV4, LGR5, TP63, VAMP8, ADAM23, BECN1, MBTPS1, RIPK1, TNFSF13, ETS1, EREG, PIGQ, EIF4A2, EZH2, INA, EDN1, LEP, HDAC9, DAZAP2, SPATA2, E2F3, GAB2, DUT, BCL2L11, NR1H3, TSPAN32, ACTR1A, DSG3, DNMT3A, OPTN, TCL1B, ABCG1, NCOR2, GRAP2, ARHGEF2, EIF4A1, EGR1, CYTH1, CD83, CD163, SNRNP40, APOBEC3B, EGI, HAND2, ATG5, CXCL14, CCL4L2, SPAG6, PPM1D, F2R, GUCY2C, TNFRSF1A, ZEB1, GNAO1, GPC3, NR2F2, GJB2, CBLIF, GEM, THBS1, GCHFR, THRB, THY1, TIMP1, TIMP2, TLR2, GCG, GOT2, GPI, GRM1, GRP, GTF2H1, SRY, GSTT1, GSTM1, STAT5B, GSS, CXCL1, TARBP2, SULT1A1, SYN1, TAC1, ADAM17, TAP2, TAPBP, LRRC32, GAA, MAD1L1, TNXB, FAT1, YY1, ZFP36, CNBP, FABP1, AIMP2, MLLT10, F9, IV, TCL1A, SLC7A5, F8, SYMPK, MIA, USP9X, XK, FHIT, FHL2, TSC2, G6PD, FSHR, TP53BP2, TPMT, CRISP2, TSC1, MTOR, BEST1, FRA18B, FOLR1, TXN, FLT4, FLT1, FOXO1, REG1A
Diffuse Intrinsic Pontine Glioma Wikipedia

In studies resulting from the DIPG/DMG Registry and in connection with the DIPG/DMG Collaborative, statistics reveal that approximately 150–300 patients are diagnosed with DIPG in the USA per year, the median age of patients with DIPG is approximately 6–7 years old and the male/female ratio of DIPG patients is 1:1. [4] Treatment [ edit ] The standard treatment for DIPG is 6 weeks of radiation therapy , which often dramatically improves symptoms. ... Mount St. Joseph women's basketball game ). NBA star LeBron James posted words of encouragement on Instagram , and Pat Summitt and the Indiana Pacers gave $5,000 to Hill's charity. [18] Doctors said she could become the "face" of DIPG, much in the same way that Lou Gehrig was the public face of Amyotrophic lateral sclerosis . ... She died of pneumonia, related to her weakened health, on January 28, 1962, aged two. [32] Wikimedia Commons has media related to Diffuse intrinsic pontine glioma .

ACVR1, CHEK2, BRCA2, BRIP1, H3C1, H3C4, H3C3, H3C6, H3C11, H3C8, H3C12, H3C10, H3C2, H3-3B, H3-3A, H3C7, PDGFRA, TP53, EZH2, CDK4, PIK3CG, AKT1, CD276, PIK3CA, PIK3CB, PIK3CD, DNER, VEGFA, KDM6B, GFAP, BCRP1, WT1, WEE1, TP53BP1, H3-4, OLIG2, MIR26B, MELK, NLGN3, VRK3, PPM1D, EED, MBD2, TFAP2C, NOG, SMUG1, ABCG2, HDAC9, TLN1, PTCH1, STAT3, IL4, HTR2A, H2AX, GRM1, MTOR, FKBP1AP4, FKBP1AP3, FKBP1AP2, FKBP1AP1, FKBP1A, EEF2, DRD2, CLU, CDK7, CDK6, BMI1, TNC, IL4R, XCL1, IL13, REST, KDM5A, PTPRC, PTEN, PARP1, PLK1, ABCB1, PAX3, NTRK1, NPC1, MYCN, MOS, MEN1, IL13RA2, IL13RA1, COMMD3-BMI1
- Diffuse Intrinsic Pontine Glioma Orphanet
  
  A rare glial tumor characterized by a highly aggressive, diffusely infiltrative pontine lesion generally occurring in children, affecting local nerve fiber tracts and spreading contiguously to involve adjacent structures, but also metastasizing within the central nervous system. Patients mostly present with a short history of symptoms, typically including the classic triad of multiple cranial neuropathies, long tract signs, and ataxia. Signs and symptoms of increased intracranial pressure may present due to obstructive hydrocephalus. Prognosis is poor and not related to histological grade.
Lewy Body Dementias Wikipedia

Parkinson's disease dementia is the diagnosis when Parkinson's disease is already well established before the dementia occurs. [10] Epidemiology [ edit ] Between 5% and 25% of diagnosed dementias in older adults are due to Lewy body dementias. [11] [a] As of 2014, the Lewy body dementias affect about 1.3 million people in the US and 140,000 in the UK. [6] LBD usually develops after the age of 50. [7] Men are more likely to be diagnosed than women. [7] Society and culture [ edit ] Advocacy and awareness [ edit ] As of 2014, the Lewy body dementias were more often misdiagnosed than any other common dementia. [6] Most people with DLB had not heard of the condition prior to diagnosis; general awareness about LBD lags well behind that of Parkinson's and Alzheimer's diseases, even though LBD is the second most common dementia, after Alzheimer's. [6] It is not only frustrating for families and caregivers to find that few people, including many healthcare professionals, are knowledgeable about LBD; lack of knowledge can have significant health consequences because people with LBD have severe sensitivity to antipsychotics often used to treat the symptoms. [6] The Lewy Body Dementia Association (LBDA) and the UK Lewy Body Society promote awareness and provide support that helps society, by reducing costly use of healthcare, and families with LBD, by reducing stress. [6] These organizations, and others in Argentina, Australia and Japan, help raise knowledge and help families with LBD become advocates to raise awareness about the disease. [6] Notable individuals [ edit ] Further information: List of people diagnosed with Parkinson's disease Robin Williams (shown in 2011): his widow said he was diagnosed on autopsy with Lewy bodies. [18] [19] Robin Williams , the American actor and comedian, died on August 11, 2014. ... "Pharmacological management of dementia with Lewy dodies" . Drugs Aging (Review). 36 (4): 309–19. doi : 10.1007/s40266-018-00636-7 . ... National Basketball Association (Press release). NBA Media Ventures, LLC. May 22, 2020 .

SNCA, APOE, CYP2D7, CYP2D6
Thoracic Outlet Syndrome Wikipedia

Specialty Vascular surgery , thoracic surgery Symptoms Pain, weakness, loss of muscle at the base of the thumb , swelling, paleness, bluish coloration [1] [2] Usual onset 20 to 50 years of age [1] Types Neurogenic , venous , arterial [1] Causes Compression of the nerves, arteries, or veins in the passageway from the lower neck to the armpit [1] Risk factors Trauma , repetitive arm movements , tumors , pregnancy , cervical rib [1] Diagnostic method Nerve conduction studies , medical imaging [1] Differential diagnosis Rotator cuff tear , cervical disc disorders, fibromyalgia , multiple sclerosis , complex regional pain syndrome [1] Treatment Pain medication, surgery [1] [2] Frequency ~1% [3] Thoracic outlet syndrome ( TOS ) is a condition in which there is compression of the nerves, arteries, or veins in the passageway from the lower neck to the armpit . [1] There are three main types: neurogenic , venous , and arterial . [1] The neurogenic type is the most common and presents with pain, weakness, and occasionally loss of muscle at the base of the thumb . [1] [2] The venous type results in swelling , pain, and possibly a bluish coloration of the arm. [2] The arterial type results in pain, coldness, and paleness of the arm. [2] TOS may result from trauma , repetitive arm movements , tumors , pregnancy , or anatomical variations such as a cervical rib . [1] The diagnosis may be supported by nerve conduction studies and medical imaging . [1] Other conditions that can produce similar symptoms include rotator cuff tear , cervical disc disorders, fibromyalgia , multiple sclerosis , and complex regional pain syndrome . [1] Initial treatment for the neurogenic type is with exercises to strengthen the chest muscles and improve posture. [1] NSAIDs such as naproxen may be used for pain. [1] Surgery is typically done for the arterial and venous types and for the neurogenic type if it does not improve with other treatments. [1] [2] Blood thinners may be used to treat or prevent blood clots . [1] The condition affects about 1% of the population. [3] It is more common in women than men and it occurs most commonly between 20 and 50 years of age. [1] The condition was first described in 1818 and the current term "thoracic outlet syndrome" first used in 1956. [2] [4] Contents 1 Signs and symptoms 2 Causes 3 Diagnosis 3.1 Classification 3.1.1 By structures affected and symptomatology 3.1.2 By event 3.1.3 By structure causing constriction 4 Treatment 4.1 Physical measures 4.2 Medications 4.3 Surgery 5 Notable cases 6 See also 7 References 8 External links Signs and symptoms [ edit ] TOS affects mainly the upper limbs, with signs and symptoms manifesting in the shoulders, neck, arms and hands. ... Potential complications include pneumothorax , infection, loss of sensation, motor problems, subclavian vessel damage, and, as in all surgeries, a very small risk of permanent serious injury or death. [ citation needed ] Notable cases [ edit ] Sports Several Major League Baseball players, especially pitchers, have been diagnosed with thoracic outlet syndrome, including Chris Archer , Matt Harvey , [19] Chris Carpenter , [20] Jaime Garcia , [21] Shaun Marcum , [22] Matt Harrison , [23] Clayton Richard , [24] Nate Karns , [25] and Noah Lowry . [26] Starting pitcher Chris Young , who previously struggled with shoulder problems, underwent surgery for TOS in 2013 and felt "completely different" post-recovery. [27] Young exceeded expectations on his return to the major leagues at age 35, becoming a valuable member of the 2014 Seattle Mariners ' starting rotation. [28] NHL defenseman Adam McQuaid was diagnosed with TOS in September 2012, and as a result was nominated for the Bill Masterton Memorial Trophy . [29] Forward Chris Kreider was diagnosed with a malformed rib in 2017. ... Kreider underwent successful surgery to resect a rib in January 2018 (the same surgery as TOS) and has performed well since returning to the Rangers. [30] NBA guard Markelle Fultz was diagnosed with TOS in December 2018. [31] [32] UFC fighter Matt Serra had a rib removed to alleviate TOS. [33] Music Musician Isaac Hanson had a pulmonary embolism as a consequence of thoracic outlet syndrome. [34] The Japanese band Maria disbanded in 2010 due to drummer Tattsu's TOS which made it impossible for her to continue playing. [35] In 2015, singer Tamar Braxton had to leave Dancing With The Stars due to TOS. [36] See also [ edit ] May–Thurner syndrome – a similar compressive pathology involving the left common iliac vein Backpack palsy – a similar compressive pathology involving the long thoracic nerve, or adjacent brachial plexis nerves References [ edit ] ^ a b c d e f g h i j k l m n o p q r s "NINDS Thoracic Outlet Syndrome Information Page" .

FOXO3, RPTOR
- Thoracic Outlet Syndrome Mayo Clinic
  
  Females are greater than three times more likely to be diagnosed with thoracic outlet syndrome than are males. Age. Thoracic outlet syndrome may occur at any age but is most commonly diagnosed in adults between the ages of 20 and 50.
- Thoracic Outlet Syndrome Orphanet
  
  Thoracic outlet syndrome (TOS) is a group of disorders characterized by paresthesias, pain and weakness of the upper extremities due to compression, tension or inflammation of the neurovascular bundle as it passes through the thoracic outlet. There are 3 forms of TOS with different clinical pictures and etiologies: neurogenic TOS (NTOS) that can be divided into true or disputed forms, arterial TOS (ATOS) and venous TOS (VTOS) (see these terms). Epidemiology The diagnosis of TOS remains controversial so the true incidence is unknown. Neurogenic TOS is the most frequently observed form accounting for 95% of all cases with 99% of these being disputed NTOS. Clinical description Compression typically occurs at the interscalene triangle, the costoclavicular space between the first thoracic rib and clavicle, or the subcoracoid space beneath the pectoralis minor tendon causing pain, paresthesias and weakness in the upper extremities.
Dihydrolipoamide Dehydrogenase Deficiency GeneReviews

Evaluation of relatives at risk: Testing of all at-risk sibs of any age is warranted to allow for early diagnosis and treatment of DLD deficiency and to avoid risk factors that may precipitate an acute event. ... Recurrent liver injury/failure frequently preceded by nausea and emesis Age of onset ranges from the neonatal period to the third decade. ... Ketonuria, irritability, & poor feeding Age 4-5 days. Deepening encephalopathy manifesting as lethargy, intermittent apnea, opisthotonus, & stereotyped movements (e.g., "fencing" & "bicycling") Age 7-10 days. ... Nutritional support Dextrose-containing IV fluids (6-8 mg/kg/min) w/age-appropriate electrolytes &/or frequent feedings Metabolic acidosis Consider correction using sodium bicarbonate (see Table 10). ... The frequency of acute episodes decreases with age in most patients with all forms of DLD deficiency.

DLD, PDP1