A rare, acute myeloid leukemia characterized by evidence of granulocytic maturation and more than 20% of blast cells in the bone marrow and/or peripheral blood. The maturing non-blast granulocytic cells account for greater than or equal to 10% and monocytic cells less than or equal to 20% of the bone marrow cells. Various degrees of anemia, thrombocytopenia, or pancytopenia are present. Frequent clinical manifestations include fatigue, fever, bleeding disorders, and organomegaly, especially hepatosplenomegaly.
., eds. (2003). Complex Trauma in Children and Adolescents: White Paper from the National Child Traumatic Stress Network, Complex Trauma Task Force (PDF). ... In Corless, Inge B.; Germino, Barbara B.; Pittman, Mary (eds.). Dying, death, and bereavement: theoretical perspectives and other ways of knowing.
A number sign (#) is used with this entry because of evidence that aggressive periodontitis-1 is caused by homozygous mutation in the CTSC gene (602365) on chromosome 11q14. Description Aggressive periodontitis, which may be generalized or localized, is characterized by severe and protracted gingival infections, leading to tooth loss. Amounts of microbial deposits are generally inconsistent with the severity of periodontal tissue destruction and the progression of attachment and bone loss may be self arresting (American Academy of Periodontology, 2000). The term 'aggressive periodontitis' replaced the terms 'early-onset,' 'prepubertal,' or 'juvenile periodontitis' at a 1999 International workshop for a classification of periodontal disease and conditions, where it was decided that the classification terminology should not be age dependent or require knowledge of rates of progression (Armitage, 1999). Genetic Heterogeneity of Aggressive Periodontitis Aggressive periodontitis-2 (608526) has been mapped to chromosome 1q25.
Description Adenomyosis is characterized by the presence of endometrial glands and stroma within the myometrium. Abnormal uterine bleeding and dysmenorrhea are the most characteristic symptoms, occurring in approximately 65% of cases (Arnold et al., 1995). Inheritance Emge (1962) noted a possible hereditary factor in the occurrence of adenomyosis because of his finding of 7 mother-daughter pairs who had undergone surgery for adenomyosis over a 15-year period. Arnold et al. (1995) reported a family with adenomyosis in 3 successive generations; 2 sisters, their mother, and their maternal grandmother were affected. Either autosomal or X-linked dominant inheritance is possible. GU - Adenomyosis Lab - Endometrial glands and stroma within the myometrium - Abnormal uterine bleeding - Dysmenorrhea Inheritance - Autosomal vs.
The 7q11.23 duplication syndrome should be added to the list of syndromes that are associated with aortic dilation: Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndromes (see Ehlers-Danlos Syndrome, Classic Type, Ehlers-Danlos Syndrome, Hypermobility Type, Ehlers-Danlos Syndrome, Kyphoscoliotic Form, and EDS vascular type), and familial thoracic aneurysm.