- Pinealoblastoma Wikipedia
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Opitz G/bbb Syndrome
Orphanet
Malformations include hypospadias (80%), imperforate or ectopic anus (20%), laryngeal cleft (50%), dysphagia, reflux and other esophageal problems (30%) and, less commonly, congenital heart malformations (20%) and agenesis of the corpus callosum or hypoplasia of the vermis. ... Female carriers mostly show only hypertelorism (>90%) and rarely other manifestations. ... Etiology Opitz GBBB is caused by mutations in the MID1 gene (Xp22) encoding the midline-1 protein which is an ubiquitin E3 ligase associated with microtubules.
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Sticky Platelet Syndrome
Wikipedia
In a lab test called aggregometry platelet stickiness is stimulated with epinephrine (EPI) and/or adenosine diphosphate (ADP). [10] This test is not possible for patients being treated with acetylsalicylic acid until that substance has sufficiently cleared from their system. [ citation needed ] Treatment [ edit ] Those diagnosed are usually treated with taking a low dose (80–100 mg) Aspirin a day. [11] Anticoagulants (e.g. ... Thrombelastography is more commonly being used to diagnose hypercoagulability and monitor anti-platelet therapy. [ citation needed ] See also [ edit ] Thrombophilia References [ edit ] ^ Mammen EF (1999). "Sticky platelet syndrome" . ... PMID 10548069 . ^ Frenkel EP, Mammen EF (February 2003). "Sticky platelet syndrome and thrombocythemia". ... PMID 18662911 . S2CID 42202617 . ^ Mammen EF, Barnhart MI, Selik NR, Gilroy J, Klepach GL (1988). " " Sticky platelet syndrome": a congenital platelet abnormality predisposing to thrombosis?". ... Thrombosis Research . 107 (6): 325–328. doi : 10.1016/S0049-3848(02)00351-1 . PMID 12565719 . ^ Mammen EF (1999). "Sticky platelet syndrome" .
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Hyperglycinemia, Lactic Acidosis, And Seizures
Omim
Studies of cells from the 2 probands showed decreased activity of the pyruvate dehydrogenase complex with absent or decreased lipoylated E2 subunits. Patient cells also showed absent activity of the glycine cleavage enzyme system. ... Immunohistochemical and immunoblot studies showed a decrease in the E2 (608770)- and E3 (238331)-binding proteins of the pyruvate dehydrogenase complex, the E2 subunit of alpha-ketoglutarate (126063), and lipoic acid.
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Arthrofibrosis
Wikipedia
References [ edit ] ^ Maloney MD, Sauser DD, Hanson EC, Wood VE, Thiel AE (April 1988). "Adhesive capsulitis of the wrist: arthrographic diagnosis". Radiology . 167 (1): 187–90. doi : 10.1148/radiology.167.1.3347720 . ... PMID 10496569 . ^ Paulos LE, Wnorowski DC, Greenwald AE (1994). "Infrapatellar contracture syndrome. ... "Arthroscopic treatment of the arthrofibrotic knee". Arthroscopy . 20 Suppl 2: 187–94. doi : 10.1016/j.arthro.2004.04.036 . ... The American Journal of Sports Medicine . 22 (2): 184–91. doi : 10.1177/036354659402200206 .
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Chvostek Sign
Wikipedia
Lancet . 352 (9125): 391–6. doi : 10.1016/S0140-6736(97)10535-9 . PMID 9717944 . ^ Flink, EB (1981). ... Supplementum . 647 : 125–37. PMID 7020347 . ^ Goljan, EF. Rapid Review Pathology. Mosby, Elsevier, 2007; pp. 504. ^ a b Méneret, A; Guey, S; Degos, B (Mar 12, 2013). "Chvostek sign, frequently found in healthy subjects, is not a useful clinical sign" . Neurology . 80 (11): 1067. doi : 10.1212/WNL.0b013e31828728bc . ... "The Chvostek sign; a clinical study". American Journal of Surgery . 96 (1): 33–7. doi : 10.1016/0002-9610(58)90868-7 .
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Type 2 Diabetes
Wikipedia
"Diabetes and obesity: the twin epidemics". Nature Medicine . 12 (1): 75–80. doi : 10.1038/nm0106-75 . PMID 16397575 . ... Bulletin of the World Health Organization . 91 (9): 671–682D. doi : 10.2471/BLT.12.113415 . ... Diabetes Research and Clinical Practice . 89 (3): 309–19. doi : 10.1016/j.diabres.2010.04.012 . ... Seminars in Cell and Developmental Biology . 103 : 76–82. doi : 10.1016/j.semcdb.2019.12.002 . ... The Journal of Clinical Endocrinology and Metabolism . 99 (10): 3551–60. doi : 10.1210/jc.2014-2136 .PPP1R3A, HNF4A, PAX4, AKT2, GCK, IRS1, KCNJ11, HNF1A, HNF1B, SLC2A4, NEUROD1, PDX1, SLC2A2, IRS2, WFS1, HMGA1, ABCC8, CDKAL1, INS, INSR, ENPP1, ADCY5, CAPN10, TCF7L2, PPARG, TGFB1, LIPC, BCL2, MAPK8IP1, HP, NOS3, PPARGC1A, HMOX1, LEPR, ICAM1, UCP2, LEP, SIRT1, ADIPOQ, EDNRA, EDN1, TNF, TNFRSF1A, NOS2, KL, CPT1A, SNAP25, ATP2A2, EDNRB, RETN, GCKR, SLC30A8, GLIS3, GCGR, FTO, GLP1R, PTPN1, JAZF1, KCNQ1, IGF2BP2, MTNR1B, THADA, HMG20A, NOTCH2, PROX1, KCNK16, GPD2, UBE2E2, AP3S2, MAEA, CMIP, PEPD, GRB14, CCND2, PLEKHA1, DGKD, ZFAND3, ITGA1, PSMD6, PAM, KSR2, NFATC2, CAT, SHBG, MIR375, SLC2A1, BRAF, SLC1A2, ST6GAL1, HHEX, JADE2, IL13RA1, MIR126, SOD2, VPS26A, GSTM1, MOK, GNB3, GCG, CNKSR2, AUTS2, IGF2, GP2, INPPL1, SREBF1, SOD1, FGF21, LPL, ZNF257, FBN1, USP48, PPARA, SCTR, EPC2, IAPP, FAM234A, KLF14, CYBA, RNF6, IDE, ETS1, GIPR, CASP3, TNFRSF1B, SFRP4, OGG1, ND1, ADAMTS9, GPX1, AR, NFKB1, MIR27A, EGFR, MIR192, PCSK2, COX2, PRKCB, MIR144, HBA1, TIMP1, C2CD4A, ATF3, SLC22A3, MIR221, TMEM18, C3, C2CD4B, MIR483, MIR222, MIR423, RELA, FAS, CISD2, CBS, HK1, ATP2A3, MIR130B, HLA-DRB5, MIR203A, MIR142, CCDC92, MIR140, MIR200A, MIR98, MIR204, PAX6, ECE1, MIR214, ITLN1, MIR10B, MIR30A, MIR377, MIR1260A, CDO1, RARRES2, CCR5, SMAD5, MAT1A, NUS1, MIR1249, MIR1296, MAPK8, MIR1226, MIR1306, MRAS, MIR1228, MIR744, MIR939, CD36, MIR885, MIR1307, MIR151A, GPT, RBP4, IGF1, ID1, MIR127, MIR215, HSD11B1, MIR205, HPX, MIR195, MTOR, MIR141, GIP, HIF1A, MIR181C, GH1, UCP3, SOCS3, MIR17HG, MIR125B1, MIR432, MIR92B, MIR628, MIR532, MIR487B, BCL2L11, CYP1A2, S100A6, IL6, MIR485, MIR409, MIRLET7D, CCL2, MIR339, MIR335, MIR1301, MIR33B, MIR1908, MIR3173, MIR4482, BCL2L1, MIR4516, MIR8061, MIR6741, PRKAA1, PCK1, PCSK1, NFE2L2, BHMT, MIR7704, PPARD, MIR1260B, NUCB2, NKX6-1, ADRA2A, SERPINF1, AKT1, ZC3HC1, AGER, SERPINE1, MIR6803, KCNU1, AVP, MIR2116, MAPK1, TMEM155, MMP9, CASP8, PTGS2, G6PC, NR3C1, GSK3B, IGF1R, CCN2, REG3A, PIK3R1, CALCA, MAPK3, MAFA, HMGCR, MMP3, NPPB, SERPINA12, CRTC2, PC, ABCG2, CD38, BECN1, BAX, MMP1, PRKCZ, PTGDS, PRKN, MADD, HTR2C, AGTR2, TRPC1, ARRB2, LNPEP, AOC3, TRPC6, DCX, DEFB1, SMAD4, MIF, DNMT1, SLC9A1, CARTPT, NOG, PLAT, PLN, MTNR1A, UGT1A1, NFE2L1, DNM1L, CYP2E1, PPP1R3C, FOXM1, UGT1A6, SRD5A1, NR1D1, NOS1, THBD, AGRP, GJA1, PRKCE, CYB5R4, MAPK9, TGFBR2, CCKAR, CDKN2B, MAPK14, ACOT2, CYTB, MKI67, CTF1, SCN1B, DAG1, F7, ANKRD23, COL3A1, OXCT1, FEM1B, SRC, CALM1, CYP11A1, HSD3B1, KLF11, MAP1LC3A, KCNMB1, ARX, NCOA6, HSD17B3, TSPAN8, PNPLA3, GPT2, CASP7, BAD, ABCC2, ASIP, CASP12, PHOX2A, EPAS1, ATP2A1, PPP2CA, AK1, GADD45GIP1, AANAT, ATP5F1B, SLC16A11, STAR, BEST1, MPST, MTR, ALDOB, PRKCI, CCHCR1, MC4R, LMNA, CRHR1, EIF3F, SDF2L1, HLA-DQB1, SLC12A3, ATF6, CDKN2B-AS1, CAMK1D, NEUROG3, CTNNB1, ALMS1, ARAP1, ATM, UMOD, CDC123, ANK1, GRK5, DUSP9, NOX4, ABO, CYP19A1, ARL15, ELN, SRR, TP53INP1, CASR, TM6SF2, PTPN22, KIF11, CUBN, MAP2K7, TMEM163, GPR55, SCGN, TFAP2B, AGMO, HMGA2, DNER, ALDH7A1, RBMS1, HECTD4, RFC2, LAMA1, AHR, PRPF31, SLC26A9, PROM1, CTBP1-DT, ARG1, UBE2Z, DGKB, POU5F1, AHI1, ZMIZ1, RP9, INS-IGF2, ZRANB3, COBLL1, FAF1, TCF19, PRC1, ACSL1, TH, ND5, PTPRD, RASGRP1, GLP2R, RBPJ, TUB, GATAD2A, BAZ1B, LINGO2, NRL, ALK, PBX4, SSR1, NDUFAF6, PRKAG2, CLIP2, WRN, POC5, DHDDS, OAS1, SNHG17, ABCA4, SGCD, SLC16A13, CAMTA1, CTRB1, ADGRL3, EHMT2, SPPL3, STUB1, CAMK2G, TRDN, MACF1, TSBP1, STX8, TTLL6, PTPRN2, CAMKK2, RREB1, TRPM1, BCL9, LIG4, ATXN1, CTBP1, SUGP1, ROM1, TPCN2, MPHOSPH9, MCM6, SH2B3, POMGNT1, MASP1, FBXW7, RBPJL, SGCG, LIMK1, PPP2R2C, PDE6B, CERKL, FAM161A, RBP3, HIVEP2, HLA-DRB9, HLA-DOB, PRIM2, GPR119, MAGEC3, ASCC2, HK2, PRPH2, PEX10, HLA-DRB1, HGSNAT, SSTR4, NPY, SUMO4, ARL6, MNX1, GUCA1B, LCN2, UNC5D, MOG, OSBPL7, PCSK9, TRNL1, NECTIN2, PRKAA2, RTN4RL1, TCF7, TTC8, MAK, PYY, CYB5D2, TTC39C, MAP6, DLEU7, MFAP1, CFAP77, RELN, MBNL1, RFLNA, EDARADD, RDH12, MCC, LINC02694, LINC01344, RPSAP52, PSMD9, PCARE, TNFRSF11B, NTRK2, PRKAB1, MMP2, PDE6G, NRG4, ST6GALNAC3, APOA5, LPA, CTTNBP2, NTRK3, LRMDA, PDE6A, ZSWIM3, LTA, HFE, PTH1R, PTH, PTGFRN, PCNT, REG1A, RHO, OSBPL1A, SLC5A2, ZNF513, SELE, CCDC149, C8orf37, CCNQ, PRRX1, PLCD1, IFNG, SLC5A1, IDH3B, IMPDH1, LINC01010, PLCB3, IL17A, IDH3A, IL18, SLC9B2, C17orf58, ND6, PPARGC1B, SELP, ZNF775, IL10, PLG, TRNQ, TRNS1, TRNS2, TRNK, SI, TRNH, TRNW, IL1RN, TRNF, IL4, IL1B, TRNE, IL1A, ST3GAL4, ST3GAL3, PPIL6, PDILT, CXCL8, ARL9, NEK2, ND4, REN, RP1, EYS, KCNQ3, PIK3CD, SPP1, HORMAD2, CHCHD6, RP2, PIK3CB, PIK3CA, NLRP3, MTHFR, SLCO4C1, SDHAF4, MSH3, RLBP1, KIF9-AS1, RGS13, RGS7, RGR, RFC1, NFKBIL1, RPGR, RPE65, MRPL12, CNDP1, CDHR1, COX3, REEP6, COX1, FFAR4, GPBAR1, SCD, ATXN7, ATXN2, SLC22A1, SAG, HNF1A-AS1, ZNF101, GOLGA6A, PON1, PIK3CG, TTLL8, CHMP4B, IL17REL, EHMT1, LINC01122, KCNQ1OT1, INTS8, RAB3GAP1, ENPP7P10, RALY, NLGN1, CPEB3, MGLL, MINDY1, SPATA7, CD59, CD81, UBAP2, ARHGAP15, CDK5, NUDT6, POLR3A, KIZ, CDKN2A, TRIOBP, SNRNP200, PALLD, ZHX3, LINC00844, ABCB9, ABCB10, CRB1, PRC1-AS1, BRS3, ARHGEF18, RPGRIP1L, ADAMTS9-AS2, LINC01426, CAD, UBE2E2-AS1, PROX1-AS1, CA4, OSER1-DT, SLC30A10, FBXL7, CEP68, ZZEF1, ANGPTL8, APOM, ARPIN-AP3S2, LMCD1-AS1, CNR1, ZBED3-AS1, ACKR3, MERTK, PDSS2, ATP8B2, DLEU1, LRFN2, RAMP2, CALCOCO2, CPA1, GPR158, TOPORS, STARD9, NAMPT, FRY, CRP, CRX, PITPNM2, CNGA1, CNGB1, GTF2I, NFAT5, PNPLA6, CETP, KLHL7, TEX14, ANKH, LINC00271, RAI1, HMGA2-AS1, CXCR6, PRPF8, SUMO2P17, CHUK, YKT6, ZGLP1, TXNIP, CLCNKB, C1GALT1, PRCD, ARL2BP, BLM, NR2E3, LOC102723407, AGT, AGTR1, LRP12, LINC02030, AHSG, PURG, LINC02484, ALB, LINC02841, PELO, AKR1B1, EXOC6, HPGDS, PALD1, FOXP1, CCND2-AS1, NSG1, LINC02576, SND1, LRP1B, FSCN3, ADRB3, ADIPOR1, ABCA1, ANKFY1, SNX7, PEX5L, GLRX5, HSD17B12, ASB3, ANGPTL4, ADA, ADRB2, ADARB1, SOST, IMPG2, GHRL, SCAPER, LINC01611, ADRA1A, ADRA2B, TBL2, ANPEP, RCBTB1, VPS33B, HNF4A-AS1, OSBPL3, SCAANT1, TXNL4B, PTPN23, MIR5094, ABI3BP, PINX1, SAMM50, FSCN2, BBS2, PRPF6, SRBD1, DIANPH, BDNF, DARS2, BGLAP, SBNO1, AMACR, LINC00824, ASCL2, LINC02010, APP, GIN1, APOA1, APOB, APOC3, HORMAD2-AS1, IFT172, APOE, CNTLN, APRT, POLDIP2, ETS1-AS1, PABPC4-AS1, LINC01339, TSBP1-AS1, C5orf67, ARL3, PKN2-AS1, GPSM1, TSPAN3, PCSK6, CST3, AGBL5, PABPC4, PEA15, EXT2, EYA2, OASL, FABP4, GDAP1L1, FABP2, OFD1, GCC1, ADIPOR2, NPRL3, IFT88, FGF23, FGF14, ZNF408, BEST3, MIR29A, ESR1, ALDH1A2, PRPF3, PIM3, NRXN1, NRXN3, PIEZO2, LRAT, LPAR2, XYLT1, PRPF4, APLN, KIF9, SEMA4A, SELENBP1, CLN8, MGAM, MTMR3, AKTIP, ZSCAN20, ZIC1, THSD4, TLR4, TULP1, TNKS2, ZNF34, GOT2, TP53, TNFAIP6, SLC2A10, FFAR1, UCP1, C16orf74, GPR42, TGFBR3, MLX, LINC02245, GSTP1, GSTT1, SPHKAP, MIR146A, FOXO1, GABPA, XRCC4, SCD5, CPED1, PCNX2, VWF, VSNL1, BICC1, GABRA4, USH2A, GABRG3, GAD1, GAD2, VEGFA, VDR, VCAM1, CLRN1, MED23, YTHDC2, DPP4, UBE3C, GTF2IRD1, DSPP, RHOBTB1, ACE, G6PC2, DECR1, MAGI2, DBP, SLC7A14, CLOCK, FCHSD2, ACE2, SINHCAF, USP3, CELSR1, RBM19, FGF19, MIR4435-2HG, RAPGEF5, GDF15, MTSS1, UVSSA, SFI1, CYP2C9, WSCD2, DEPDC5, TRIB3, DHX38, IFT140, SENP2, CYP21A2, KIAA1549, DOCK4, DARS1, MRPS35, BCHE, LIPE, AIMP2, RNF19A, LDLR, USF1, ARNTL, NOS1AP, AHSA1, GSTK1, PTEN, RBM45, RENBP, CTLA4, IGFBP1, CRK, GRAP2, DMD, GYS1, PON2, CCL5, POMC, IGFBP3, MME, STAT3, LGALS3, CYP2C19, SLCO6A1, LPIN1, F3, STAP2, APOA2, AQP7, FOXA2, SST, SLC17A5, MET, HMGB1, GPR151, NIDDM1, SELENOP, NIDDM2, GPRC6A, PCK2, GGT1, OR10A4, DIO2, HSPA5, GC, CYP3A4, LINC01672, MPO, GGTLC5P, SIRT6, TLR2, GLO1, ELMO1, BCL11A, MLXIPL, ARID4B, NRF1, P2RX7, MIR155, MSTN, CYP2B6, ACR, GGTLC3, MRGPRX1, ALDH2, PDR, GGT2, MRGPRX3, APOL1, HSPA1A, SIRT3, GPR166P, VN1R17P, OXER1, SLC2A11, FZD4, FNDC5, SNCA, MRGPRX4, MIR21, HSPA4, ABCG1, HSPA1B, LPAR3, CHI3L1, NR3C2, FGF2, CD14, ISL1, HAMP, LGR6, ARNT, ZBTB7C, CAV1, GGTLC4P, SGK1, PSEN1, NR1H4, CISD1, SELENOS, CD163, TMBIM4, VIP, CCN4, MFN2, ROCK1, IL22, GGTLC1, VIM, SLC22A2, SOD3, PLIN1, OGA, CNBP, PLA2G2A, SAT1, HAVCR1, FETUB, SFRP5, NAT2, EPO, IARS1, GLUL, LBP, MIR27B, STS, APOA4, ACACB, KNG1, MIR29B1, GAS6, IL15, CD44, HLA-DQA1, ATN1, FXN, CD68, ADM, MIR29B2, LOC102724197, MEFV, CRY2, HGF, FGF1, MTTP, DDIT3, ANGPTL3, BCL2A1, SIRT2, DKK1, INSRR, KCNJ4, IL33, FADS2, CASP1, IL6R, IL37, CCK, SORT1, TBC1D4, MT1A, HEBP1, PRL, MBL2, PARP1, GRK2, ARHGEF11, ROS1, TRPM5, PTX3, FADS1, PYCARD, IL2RA, KRT16, IL5, XPR1, IL2, BMP4, HIRA, LPAL2, FABP1, PADI4, CHDH, FANCD2, PTK2B, BRCA2, SOCS1, FN1, XBP1, SLC47A1, FOXC2, SLBP, PLA2G7, FGB, GHSR, DGAT1, LIPG, EPHB2, IGFBP2, MIR34A, ELANE, MT2A, HSPG2, SOAT1, DPPA3, SULT1E1, TPD52, SH2B1, HHIP, HDLBP, NR1I2, AZU1, MIR122, BTC, CPE, MAP4K4, PDHX, STAM2, NCAM1, ACP1, CMKLR1, NGF, NHS, PKD1, UTS2, MYH9, PGC, MTCO2P12, IFNL3, RAPGEF1, SORCS1, KIR3DL1, GPX3, KDR, P2RY12, TIMP3, SNAP23, FLVCR1, GRN, HDAC9, AMY2A, TNFSF14, COMT, RPL29, GPD1, PDE3B, RAPSN, DACT1, SPX, TRAF6, PVT1, CYP2D6, AKR1A1, KEAP1, MIR223, ALOX12, HDAC3, MARCHF1, ISG20, RNU1-1, ANGPT1, C1QTNF9, TNMD, GAS5, IL13, CXCL12, SPARC, ENO1, CCL16, GPR142, CXCL10, ENHO, STRA6, ST13, TFRC, NPC1, CACNA1E, STK11, STX1A, CCR2, PDK4, RUNX2, NRG1, ERBB2, S100A9, SQSTM1, C1QL3, BCAR1, CLPS, LRG1, TOMM40, GEM, ACACA, DDAH2, FKBP5, CISH, CDK4, LGR5, METRN, MUSK, CREB1, MIR17, FLAD1, TAS2R13, CD40LG, PSMA6, MIR143, SLC39A7, CLU, POU2F1, NR1H3, PTGES2, FOXP3, OLR1, PCNA, LRP5, GAPDH, SLC2A9, ABCB6, PRKCA, NR0B2, XRCC1, ENSA, CXCR4, F5, PLA2G10, NR4A1, PLA2G6, ABCG5, ACHE, FOXO3, FBRS, STAT5A, P2RX3, CACNA1D, FSD1, HPSE, NPPA, FGFR1, KLK3, ARSA, PRMT1, IGF2R, CHGA, KLF4, PPP1R3B, DHX40, ANXA1, PNPLA2, ELAVL2, ERP44, CIDEC, PRDM16, FBXO8, BMP7, VPS13C, STEAP4, NNMT, CCNL1, MCIDAS, HSPA2, APOD, KHDRBS1, APOH, DST, MIR30D, ADAM17, FCGR3B, FCGR3A, ISYNA1, POU2F3, OSM, MIR145, SMUG1, B2M, NR1H2, NTS, MIR152, TNFSF10, WNK1, UTS2R, TM7SF2, GGCT, WNT5B, TNFRSF12A, NUP62, DDAH1, COL18A1, CMA1, IMPACT, HEMGN, GFAP, TNFSF11, F2, SP6, F2R, OGN, FAAH, PDE5A, BTF3P11, IL18R1, PBX1, ERBB4, NBEAL2, SIRT4, TCF4, SIRT5, HCCS, ELOVL6, GTF2H1, TTR, CILP2, TEK, FSD1L, TERF1, TFAM, PHLPP1, BACE2, TRPV1, MIR182, G6PD, ESR2, VEGFC, TGFBI, GRB10, TGM2, BMP2, OPA1, PARL, LINC01194, SLC6A4, ENTPD1, PRKG1, CENPJ, DRD2, LOX, KCNJ1, DCTN4, MC3R, PPIG, TUBB4B, JAK2, JAK1, S100A8, CERS6, ITGAM, NOD1, SPRY2, RNR2, JPH3, ITGA2B, LAD1, TMEM154, LITAF, STK38, PTPN2, RPS6KB1, KLB, PLF, MBOAT4, UCN3, KCNMA1, ALOX5, KCNJ15, TIMM8A, SGSM3, BRD2, PLTP, CEACAM5, RRAD, PRTN3, KCNJ9, H6PD, RXRA, MUTYH, PSAT1, PROS1, IRAK1, ITGA2, ANGPTL2, PGR, AMD1P2, EBI3, LRP2, C1QTNF5, CREBRF, PPIA, ADCY3, PHOSPHO1, ABCB1, RAC1, LRP1, SFTPD, EGR1, CYP2J2, FOXD3, CAPN1, RN7SL263P, BMS1, COPA, RAD1, TFB1M, TMPRSS6, SERPINA1, C1QTNF1, AMD1, NTN1, C5AR2, CDK9, CD33, MMP8, CASQ1, METRNL, ALX4, CYP2C18, NPC1L1, TLR9, SCARB1, INTU, SELL, LARS2, CYBB, ARID1B, KLF7, MIR495, SLCO1B1, CX3CR1, DOK5, CYP2C8, CYP1A1, P2RY1, NCOA5, SLC27A4, MAGEE1, FST, GFPT2, DUSP12, LRPPRC, CDKN1B, CELA3A, RNLS, FAT1, FBN2, SLC52A2, FCGR2B, ATP6AP2, CDKN1C, PREX1, KMT2D, SEMA6A, KLHL42, CHRM3, MICA, CPT2, CDKN1A, CP, CRYZ, CDC42, COX4I1, NR1I3, FCN3, CTSD, FABP6, MIR486-1, COX8A, PDLIM5, PTPRU, CDK2, IVNS1ABP, ABCC5, POSTN, OGT, CSF2, HOTAIR, NISCH, AGXT2, BSG, P2RX2, DEFB103A, XYLT2, COL9A3, DYRK1A, MIR30C2, P2RX6, CIB1, EP300, RCAN1, FAM3A, MIR30C1, ABCG8, ATG7, MIR29C, SLC30A6, CAV3, EPHX2, ARID3A, CEBPB, GGA3, CEL, DNAJB3, MIR33A, MIR34C, MIR320A, CELA1, CAMP, CPB2, CALR, EGF, IL32, CAPN2, ADAM28, CES1, LILRB1, SLC25A20, CAPN3, SULF2, NOD2, HSPB3, EPOR, ARHGEF12, VASH1, ESRRA, TRIM72, SERPING1, ZNF410, COMP, MIR20B, PINK1, ICOSLG, CD5L, CHPT1, DAPK3, ABHD6, CYP17A1, CYP11B2, KLF5, MEG3, PDAP1, CYP3A5, SUCLA2, TXNRD2, CNDP2, ARHGAP22, TBC1D1, MEPE, KLRK1, SEMA3A, NPEPPS, AAA1, SPHK1, ATF7IP, PER2, DNASE1, FOXO6, SORBS1, TSC22D1, SARDH, NQO1, DHCR7, SOCS2, GDF11, P2RY2, NR4A3, SLAMF1, LDHA, LECT2, LGALS1, LIF, C1QTNF3, FAM3B, LMX1A, DUOX1, PVALB, ICOS, PTPRN, PTPN9, RMC1, CYP2R1, APLNR, AFP, AFM, KIF6, SMAD7, KCNIP1, ADORA1, MAPT, DUOX2, MBP, IL20, ADH1B, PLIN2, MDM2, MEF2A, NANS, FRMD3, TERF2IP, ALOX5AP, IL1R1, IL6ST, SLC39A1, IL12B, SDC2, SDC1, CXCL5, SRL, ALOX15, SPINK4, ITGAX, MSMO1, TSPAN31, S100B, COPD, SFXN1, GHS, RXRG, KCNJ6, DESI1, RRAS, PRRT2, DLL1, RORC, NPAS4, KISS1, KLK1, KRT18, PRSS55, PRKCD, LARP1BP2, HDAC7, PIK3C2G, TAAR1, NM, SLC25A3, PHB, ATP6V1H, PGF, PFKM, NOTCH1, NT5C3A, PEG3, NPHS1, BFAR, IL23A, ERFE, TRPM6, ACAT1, PDCD1, PWAR1, PCYT1A, OCA2, R3HDML, PCBD1, OPRM1, P2RX1, P2RX4, P2RX5, PAK1, ACLY, NFKBIA, PRKAR1A, POR, PRKAB2, MMP7, MMP12, MMP13, SRGN, PTPA, MMP14, MRC1, RNU6-392P, GPRC5B, GAL, MT1E, FITM2, MT1X, NF2, MTHFD1, METTL9, PLXNA2, SLC35G1, PLK1, GNPDA2, PLD1, PLCG1, PLAGL1, PLAG1, PLA2G1B, PKNOX1, PKLR, IKBKB, CHIT1, CRISPLD2, AZGP1, GSN, KLRC4-KLRK1, GSR, UGT2B15, TF, TERT, GATA6, SERPINA3, ANGPTL6, TERC, TXN2, VIPR1, UCHL1, TMEM132A, TAPBP, CFH, VLDLR, ERVK-18, C1QTNF12, HLA-DMA, ATP5PF, GAST, VTN, STX4, BID, GFER, STAT5B, TLR3, TRH, ACAD10, CRISP2, GLA, CEP55, CD2AP, CBLIF, P2RX5-TAX1BP3, MIR107, BCR, CIMT, GPR39, THBS1, TTN, GHR, FFAR2, TLE1, TKT, TXN, GCA, GPS2, KLF10, SESN2, GFPT1, ARID5B, GORASP2, MIR199A1, FGL1, SPINK1, AQP9, SOX4, SORD, SNRNP70, FKBP4, AOC2, ANXA6, SPZ1, HTN1, SLC30A1, APPL1, HTR2A, SLC16A1, TRPM7, ANGPT2, GPC5, SLC6A2, ST8SIA4, SLC2A5, ANKRD55, IGFALS, QRSL1, FHL1, MIR199A2, MIR20A, STAT4, LINC-ROR, PGR-AS1, SSTR5, WNT5A, MIR130A, ONECUT1, FLT1, SREBF2, NAT10, C4B_2, MYDGF, LOC107832851, DMAP1, LARP6, LY75-CD302, RASD1, RBM14-RBM4, LSR, NBAS, DEFB4B, MCS+9.7, HMGA1P8, LOC110806263, MMP26, RHOT1, CCL28, ALG1, METTL3, LIN7C, LINC00994, DIP, RPS10-NUDT3, GNG12-AS1, RAB14, WASHC1, CYRIB, VIM-AS1, NDUFA12, SLC50A1, NEIL3, LOC102723996, SIRT1-AS, THRIL, MIR1910, SLC38A2, ALL2, NLGN3, CASZ1, ENAH, ZFAND6, OPN1MW3, VPS35, EXOSC4, RNPC3, UGT1A10, UGT1A8, UGT1A7, ERRFI1, UGT1A5, UGT1A9, MIR3188, TEMPS, UGT1A4, BNC2, TRPM4, TET2, FBLIM1, SALRNA1, CBSL, LOC102723971, UGT1A3, TREM2, MIR3939, APPL2, MOCOS, ZC4H2, LGR4, DEFB103B, COMMD3-BMI1, MIR4756, USE1, ASAH2, ENOX1, BOP, CAMK2N1, SLC6A20, SLC52A1, CST12P, SAGE1, PLUT, WWOX, LRP1-AS, ADA2, MIR3666, IL17D, SHC3, CERNA3, HDL3, FXYD5, MIR4463, PERCC1, SOX6, UGGT2, ROBO4, DUSP26, SUCNR1, IGSF21, CISD3, TIMD4, TRIM47, KCTD1, MIF-AS1, TTC28-AS1, EXOC3L2, SLC9C1, UCN2, CYP4V2, WNT3A, GALP, SLC22A16, LY86-AS1, KRT90P, DSEL, HCCAT5, GORAB, BIRC8, AD7, RNU12, AQP11, H19, TXNRD3, SLC46A1, OPN4, PRDM6, CGB8, CGB5, MUC19, LINC00523, PGP, TRMT10A, ABCC11, BPIFA4P, HS6ST3, MMAB, PHF6, ZACN, SLC27A1, LINC-PINT, MALAT1, PPP1R1B, KAT8, CHKB-CPT1B, SLC41A2, HORMAD1, IMMP2L, LEKR1, SAMD12, MIXL1, GPR61, LINC01193, PWAR4, C7orf50, GLYR1, UBASH3B, ORAI1, PTPN5, GPIHBP1, MFSD9, HCAR2, ZNF469, ZBED3, ZGPAT, BRINP3, ZFP69, HSD17B13, ACTBL2, L3MBTL3, TIRAP, TAS2R12P, TAS1R3, NRK, CLDN19, SIK1, UPP2, PPM1K, SLC2A12, CBLL2, FAM3D, ACVR1C, DQX1, SGMS2, NLRP6, ARID2, PIFO, MLKL, TET3, PDIK1L, MTPN, LRGUK, ROMO1, OR2AG1, PIWIL4, SESN3, FGFBP3, GSC, MT1P3, HT, GPAT4, BEAN1, CD300LG, PTPRVP, SLC30A7, IL23R, FAM78B, CENPX, KLHDC7A, SGMS1, MED19, CADM2, ANGPTL5, DCD, THEM4, TADA1, AKNAD1, SLC41A1, OLIG1, SLC22A12, CASC2, ANKK1, OSBPL8, PTF1A, WDR72, NEGR1, HCG27, IL27, SPESP1, MARCHF8, FOLH1B, TPRG1L, LYPLAL1, UNC5B, TCHHL1, SKA1, MSI2, GGTA2P, JMJD1C, SLC39A12, TPPP2, SPIC, RFX6, SLC29A4, SETDB2, INHBE, MICC, MT1IP, CCAR2, MIR323B, MARK4, MIR146B, MIR202, SPTBN4, MIR496, MIR499A, MIER1, USP37, NPS, CHD8, POTEM, TSHZ3, ECSCR, HNP1, MIR424, MIR382, SLC25A19, EIF2AK4, IGAN1, NIF3L1, ELOVL5, BACH2, EXOC4, RNASEK, MIR378A, PLIN5, POTEKP, PGBP, UBL5, CXCL16, NEUROD4, POU5F1P3, CHCHD2P9, TNFSF12-TNFSF13, USP36, KMT5AP1, MUC5B, OPN1MW2, CPA6, HYMAI, CDK11A, SLC12A9, ARNTL2, CA10, SMARCAD1, OCTN3, CELF4, SPHK2, MIR708, C20orf181, MIR661, GOPC, PELI1, KIDINS220, POU5F1P4, CXADRP1, NCF1, CFAP97, WASH6P, XPO5, MIR590, MIR657, MIR593, PLEKHG5, MRS2, GJD2, ATP10A, SLC39A10, PROK2, MIR99A, TOMM5, MUL1, ASRGL1, MIR15A, MIR15B, MIR18A, MIR187, STN1, MIR200B, ADM2, PRR5L, BBS10, LIN28A, NLRX1, NEIL1, MIR206, TNFAIP8L2, MIR154, MOGAT2, MIR147A, MIR106B, MFRP, MED25, TLR10, NIPA2, MOB2, COLEC12, SETD7, ALPK1, TAS1R2, MIR125A, MIR128-1, TSEN2, MIR132, COASY, MIR210, IRX3, MIR95, MBOAT7, WDR13, MIR296, PDIA2, GORASP1, DCLRE1C, GMCL2, GMCL1, NFKBIZ, NSD1, MIR30E, FN3K, DMRTA1, MIR31, SLC17A9, UBE2O, FNDC4, GNPNAT1, RFX7, GRAMD2B, MIR217, LY6G6E, MIR219A1, KCTD15, MIR22, VKORC1, MIR23A, SLC30A5, MIR23B, BRD9, WNK4, MIR26B, FRTS1, ACD, SCLY, UTRN, LARS1, HACD3, IK, IGH, IGFBP5, IGFBP4, IFNA13, IFNA1, ICAM3, HTR4, HTR2B, HTC2, HSPD1, HSP90AA1, HSPB2, HSPB1, HSPA9, HSD11B2, HES1, HRC, HRAS, HOXA5, HNRNPK, HNRNPF, HNRNPA1, FOXA3, HMBS, IL3, IL4R, IL7, KCNJ10, L1CAM, KRT31, KRT19, KRT7, KPNA1, KIR3DL2, KIR2DS1, KEL, KCNN3, KCNN2, KCNK3, KCNJ3, CXCR1, KCND3, KCNC4, KCNB1, ITGB2, INSIG1, IMPA1, ILK, TNFRSF9, IL16, IL15RA, IL12A, HLF, HLA-DRA, HLA-DQB2, GDF1, GNAO1, GLRX, GLS, GCLC, GLB1, GK, GJA8, GJA4, GH2, GDNF, GDF2, OPN1MW, SFN, GCH1, GBP2, GATA4, GATA3, GAP43, GALNT2, GABRG2, GABPB1, FUT6, FUT2, NR5A1, GOLGB1, GPI, HLA-DQA2, HSD17B10, HLA-DPB1, HLA-DOA, HLA-DMB, HLA-A, CFHR2, HCRT, HBA2, HAS3, HARS1, HADH, HADHA, GZMB, GPM6A, GYG1, GTF3A, GSTA4, GSTA1, GRB2, FFAR3, GPR35, GPER1, GPR21, CXCR3, GPR1, LAMB3, LAMP1, LAMC2, CCN3, OAS3, NR4A2, NUCB1, NTRK1, YBX1, SLC11A2, NPY2R, NPR3, NPR2, NPR1, NPM1, NME1, P4HB, NGFR, NFYC, NFYB, NFYA, NFATC1, NEFL, NDUFS4, NAGLU, MYO5A, MYLK, MYL2, OMG, PAEP, MYF5, PDK2, PIN1, PIK3C3, PIK3C2A, SERPINE2, SERPINB6, PGM1, PFKFB3, PFKFB2, PFDN2, PER1, PECAM1, PDHB, PRDX1, PDGFRB, PDGFB, PDE4D, PDC, PDB1, PCOLCE, SERPINA5, PCDH8, PAWR, PAPPA, SERPINB2, MYH6, MYD88, LAMP2, SH2D1A, MAX, MAS1, MAOA, MAN2A1, MAN1A1, MAFD2, SMAD3, SMAD2, SMAD1, MXD1, LYZ, LY75, MC5R, LY9, LTF, LTBR, CYP4F3, LRP6, LPP, LOXL2, FADS3, LIPA, LCN1, STMN1, MB, SMCP, MUC1, MST1, MTRR, RNR1, ATP8, MT1L, MT1M, MT1JP, MT1H, MT1G, MT1F, MT1B, MSX2, MSH5, ADAM11, MSH2, MPI, ALDH6A1, KMT2A, MGST3, MGP, MGAT2, MFAP2, MAP3K5, MEF2C, ME1, FOS, FOLR2, FOLR1, CA5A, CCND3, CCKBR, CBR3, CBR1, RUNX3, RUNX1, CAV2, CAMK2A, CALCR, CACNB3, CACNA1C, CA2, CD4, VPS51, C5, CAPN5, C4B, C4A, TSPO, BRCA1, BPI, BNIP3, BMP6, BMI1, CD247, CD86, BLK, CGA, AP3S1, CKM, CKB, CIDEA, CHRNB4, CHRNA4, CHN2, CHM, CEACAM7, CEACAM3, CGB3, CFTR, CD34, CTSC, CENPA, CECR, CEBPA, CDX2, CDKN3, CDK6, CDH13, CDH2, CD48, ENTPD3, BLVRA, BGN, CLCN3, AIF1, AMY1C, AMY1B, AMY1A, BIN1, AMPD1, AMH, ALPP, ALPL, ALDH3B1, ALCAM, ALAS1, AIC, ANXA5, ADORA3, ADORA2B, ADH1C, ADD1, ADCYAP1, ACVR2B, ACTG2, ACTG1, ACTB, ACAA1, AAVS1, ANK2, APCS, CFB, ATIC, BCS1L, OPN1SW, HCN2, BCAT1, AVPR2, ATP5PO, ATP7A, ATP5MC1, ATP4A, ATP2B1, ATP12A, ATHS, BIRC2, SERPINC1, ARSL, ARR3, RND3, RHOA, AQP5, AQP2, FASLG, APOC4, APOC2, BIRC3, CLCN2, CLCN5, FOLH1, EFNB3, EPHA4, ENO2, MARK2, ELK3, ELAVL1, EIF4G1, EIF4EBP1, EIF4A2, EGR3, EGR2, CELSR2, EFNB2, EPHX1, LPAR1, TYMP, EBM, E2F1, DUSP6, DRD3, DPYS, DPYD, DPT, DNTT, DMP1, EPHB1, ERBB3, DLD, FASN, FMO3, FLNA, FLII, FHIT, FGFR4, FGF11, GPC4, FDXR, FCP1, FCGRT, FBP1, FAP, ERG, FABP5, FABP3, F2RL2, F2RL1, EXT1, EVC, ETV3, ETFA, ESRRG, ESRRB, FBL, DMBT1, SEPTIN1, CLK2, COL17A1, CS, CRMP1, CREM, CREBBP, CRABP2, CPT1B, COX10, COX7A1, COX5B, MAP3K8, CORT, COL9A2, CSHL1, COL9A1, COL8A1, COL6A3, COL4A5, COL4A2, COL2A1, COL1A1, CNTF, CNR2, CMM, CCR1, CSF3, CST2, DIAPH2, BRINP1, CFD, DES, DEFB4A, DEFA3, DEFA1, DDX3X, DDT, AKR1C2, DCN, DBI, DBH, CYP27B1, CTAA1, CYP27A1, CYP8B1, CYP7A1, CYP2A6, CYP1B1, CYB5A, CXADR, CUX1, CTSL, CTSH, CTRL, PKM, PLA2G4A, PLEK, RBM14, SPTLC1, AGPAT1, PROCR, HYOU1, CARM1, UNC13B, CAP1, TIMM44, FAM3C, IFI30, LYPLA1, SPON1, SLC19A2, SPON2, NSA2, PEMT, ATP8A1, DLC1, CITED2, KLF2, WARS2, TCIRG1, SIGMAR1, FSTL3, SLC35A1, OLFM4, OLIG2, CCL27, BTN2A1, ADAMTS13, ESM1, LIAS, METAP2, EHD1, MALT1, FGL2, NMU, CD300C, CYP46A1, PPP1R13L, NPC2, CPLX1, WASF3, STARD10, SLC17A3, CAPN9, EBP, CD226, CTCF, IGF2BP3, IGF2BP1, USP16, ZMPSTE24, FLOT1, TREH, AIM2, GDF3, CXCL14, STXBP5L, GAL3ST1, ADAMTS2, ATG5, AKAP6, CHST3, FHL5, HOMER1, EIF2AK3, ITM2B, KIF20B, NCR1, TJP2, PEX16, TMPRSS11D, TGFBRAP1, ADGRG1, PIWIL1, ITGB1BP1, MSC, LARGE1, HACD1, SOX13, WTAP, TRIM13, MAFB, NUTF2, MPHOSPH10, TSHZ1, RBM6, HIPK3, PREB, AKT3, SCO2, KCNE2, THRAP3, EXOG, RNF10, NCOR1, SGSM2, HEPH, IP6K1, TOX, HDAC4, SART3, ECE2, AQR, EIF5B, LPIN2, NCOR2, PTPRT, MAP4K5, SLC16A7, DHDH, MCTS1, RGCC, SLC27A6, REM1, TRBV7-8, IGHD1-14, SLCO1B3, PCLO, MCAT, EIF3K, PDLIM3, SESN1, KLF15, SIT1, SERP1, IL17B, DISC1, DKK4, SIGLEC7, ACAD8, GREM1, BSCL2, PCOLCE2, CNNM1, DBNL, TBK1, HSPB8, MBL3P, CSAD, WAC, BPIFA1, TLR7, DNAJC27, IGF2-AS, GP6, IPO11, HSPA14, IRAK4, SLC35B3, G0S2, MYLIP, SLC40A1, TBX21, ERO1A, SLC2A8, SLC39A3, RHOD, PADI1, GPR132, HOOK2, CD274, CTNNA3, NUPR1, MYCBP, CHEK2, FAIM2, PSD3, SYNE1, TTC28, COBL, ARC, SIK2, FBXO28, SYT11, TBC1D9, CAND2, KDM1A, NT5C2, DICER1, RAB18, SACM1L, SBNO2, CARD8, MLXIP, COG2, ACOT7, MGAT4A, SLCO2B1, PTGDR2, AKAP13, CRTC1, NCS1, KLHL3, PANX1, PITPNC1, KIFBP, ATRNL1, TENM4, TKFC, PART1, MGAT4C, ARIH1, KLK5, TAFA5, SLC39A6, LY96, ZFPM2, BACE1, ZMYND8, DAPK2, FAM215A, SEC14L2, PES1, BRD4, TRAM1, NPTXR, TRS-AGA2-3, MLYCD, SLC33A1, ZBED1, SERPINF2, XCL1, SLC2A3, SLC1A7, SLC1A5, SKP2, SKIL, SIX3, SHC1, SRSF5, SELPLG, SDHA, CX3CL1, CCL22, SLC6A8, CCL20, CCL11, CCL8, CCL7, CCL4, CCL3, SCO1, SCN8A, SCN7A, SCN2A, SAA2, SLC5A5, SLC8A1, S100A12, SRI, TADA2A, TACR3, TAC3, TAC1, SYT4, SYT1, STXBP3, STX5, STIM1, STC1, SSTR2, SRD5A2, SLC9A3, SPRR2A, SPG7, SOX5, SOX2, SORL1, SIGLEC1, SMPD1, SLPI, SLCO1A2, SLC18A2, SLC10A2, SAA1, S100A4, TAL1, DNAJC3, PTMAP4, PTMA, PTGER3, PTBP1, PTAFR, PSMD3, PSMD2, PSMB6, PSMA7, PSG2, TMPRSS15, EIF2AK2, PTPN6, MAPK7, PRKD1, PPP1R2, POU3F1, POU2F2, PODXL, SEPTIN5, PNLIP, PMM2, PML, PMAIP1, PTPN4, PTPN11, RYR2, REG1B, RTN1, CLIP1, RPS19, RPS6KA3, RPS6KA2, RPN2, RPE, RORB, RNH1, RIT2, REV3L, REL, PTPRB, RCN2, RARB, RANGAP1, RAG1, RAB27A, RAB5B, RAB4A, PYGB, PTPRS, PTPRF, PTPRC, TAF1, TCP1, HTR3B, API5, ADAM19, MBTPS1, TNFRSF25, PAGE1, VAMP4, VAMP8, HSD17B6, JRK, KHSRP, DENR, PIAS1, CST7, TNFRSF14, DGKZ, IRS4, DOC2B, DYRK3, LOH19CR1, BRAP, PICALM, ZNF239, SLC14A2, AAAS, FOSL1, TNFSF12, RAB11A, MAFK, NOL3, PCSK7, HGS, MTMR7, USP2, USP14, PAPSS2, RPL14, CCRL2, TAF1C, F2RL3, KALRN, TRPA1, RIPK2, EIF2B5, ZPR1, FUBP1, PER3, TMEM11, BANF1, GALR2, TNFRSF11A, DLK1, TNFRSF18, SIGLEC5, ECB2, HBFQTL2, PRDX2, TLL1, HSP90B1, NR2C2, TPO, TPM4, TPM1, TOP2A, TOP1, TNFAIP3, NR2E1, TLR5, TLR1, TLE3, TRPM2, TJP1, TIMP2, TIAM1, THBS4, THBS2, TGFB2, TGFA, TFPI, TFAP2A, TERF2, TEP1, TRAF3, TST, TFEB, NSD2, LAP, PRRC2A, MANF, SLMAP, ZNF236, ZFP36, SF1, YWHAG, YY1, XDH, XBP1P1, WARS1, TNFRSF4, VPREB1, VEGFB, VDAC1, UPK2, UGT1A, UGCG, SCGB1A1, UBE2B, TYROBP, TYK2, TXNRD1, LINC02605
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Diabetes Mellitus, Insulin-Dependent
Omim
Rotter and Rimoin (1978) hypothesized that there are at least 2 forms of IDDM: a B8 (DR3)-associated form characterized by pancreatic autoimmunity, and a B15-associated form characterized by antibody response to exogenous insulin. Interestingly, the DR3 and DR4 alleles seem to have a synergistic effect on the predisposition to IDDM based on the greatly increased risk observed in persons having both the B8 and B15 antigens (Svejgaard and Ryder, 1977). ... He considered autosomal recessive inheritance to be most likely, with a gene frequency of about 0.30 and a lifetime penetrance of about 70% for males and 90% for females. A gene frequency of about 0.05 and a penetrance of 25 to 30% would be required to account for the findings on a dominant hypothesis. ... Screening for 2 antibodies at once and testing for the remaining antibodies among those who were positive for 1 resulted in a sensitivity of 99% for GAA and ICA, 97% for GAA and MIAA or GAA and ICA512AA, 93% for ICA512AA and ICA, 92% for MIAA and ICA, and 73% for ICA512AA and MIAA. ... Nerup et al. (1974) found that IDDM (but not NIDDM) is associated with 2 particular HLA-A types (142800)--HLA-A8 and W15. Woodrow and Cudworth (1975) interpreted the association of HLA-A8 and W15 with IDDM as resulting from linkage disequilibrium between genes for these antigens and a gene determining susceptibility of diabetes.PTPN22, HNF1A, INS, HP, IFNG, IL2RA, CASP12, IL10, FOXP3, HLA-DRB1, HLA-DQA1, HLA-DQB1, CLEC16A, SH2B3, GLIS3, TYK2, BACH2, CTSH, C1QTNF6, CD69, CAT, NOS3, TNF, CRP, IGF1, IL6, PRKCQ, KCNJ11, PAX4, SLC29A3, STAT3, SLC11A1, FGF21, IL27, ITPR3, CP, ABCC8, NOS1, PRSS1, HSD11B2, IL20, CCR5, NEUROD1, DDIT3, ICA1, G6PC2, IGF2, PTPRN, STAT4, PTPRN2, AIFM1, CCL20, IL4, CXCL10, IL19, CHRM2, GAD2, GH1, CASP3, APOC3, PDX1, GIMAP5, NOS2, CBLB, IL1R1, LGALS3, AIF1, CD40LG, GSTT1, CD38, VWF, FASLG, CDK4, SELL, EGFR, GAL, TNFSF4, SLC18A2, DOCK8, PRF1, CCL11, AGER, IFNGR2, VAV1, HLA-DPB1, CBL, HLA-DQB2, ADRB1, UGT1A1, IFIH1, TAP2, TAP1, ERBB3, E2F1, HLA-DQA2, PTPN2, IRAK3, YY1, MICA, CD226, HLA-B, HLA-A, CFB, DUSP1, SENP1, LTA, AIRE, INS-IGF2, UBASH3A, MMP2, COX2, RPS26, HLA-DPA1, HLA-DRA, STAT1, ABO, TCF19, IL23R, APOM, PSMB9, TH, HLA-DMB, PSMB8, EIF2AK3, GSDMB, PRRC2A, NAA25, FUT2, MPIG6B, SIRPG, GATA3, BTNL2, MMP14, RNLS, DDX39B, HCG18, SUOX, LST1, AFF3, TNFSF15, MAPK14, HLA-DOB, SPINK1, HLA-DMA, RASGRP1, ND1, SBDS, HSPA1L, CTRC, CUX2, KIAA1109, MSH5, IKZF4, GLRA3, ERAP2, IKZF1, BCL2L15, PGM1, CFTR, TNXB, MEG3, MICB, NEUROG3, ADCY7, SNHG32, RAB5B, STK19, ACOXL, IGF2-AS, KIR3DL1, GPANK1, ABHD16A, SLC30A10, SMAD3, LEP, GATD3A, BTN2A3P, BNC2, H2BC15, H3C12, MAPT, SKAP2, LMO7, USO1, EDA, ATG16L1, BAG6, AGTR1, PSTPIP1, EFR3B, STUB1, HCG9, ATXN2L, IFNA1, IFNA13, EHMT2-AS1, CNOT1, TAX1BP3, FNBP1, FLOT1, NUP210, ADGRL2, CAMSAP2, IL1A, TRIM31, EHMT2, ICAM1, HCP5, HLA-C, ABCF1, PTGFR, IAPP, TRDN, HLA-DRB9, NXF1, HLA-L, AGPAT1, CORIN, HNF4A, SORBS1, TSBP1, SIRT1, GPR35, CRB1, GAD1, ZNRD1, ADIPOQ, PPT2, FLNB, FLT1, CD274, ISG20, CLEC2D, INSR, IL18, IL17A, IL13, GABBR1, GABPA, IL12B, SEC14L2, LINC02357, IL7R, ATN1, LINC02829, GCK, GEM, LINC02571, ACP1, IL2, PRKD2, GLP1R, GLUL, GNAO1, IL1B, GCG, DAG1, MBL2, TRNW, ATP6V1G2-DDX39B, PPP1R18, STOX1, MAGI3, MSH5-SAPCD1, HLA-S, OR10A4, TCF4, HECTD4, KCTD1, LURAP1L, NOTCH4, C2, REN, SUMO4, PSORS1C1, PPT2-EGFL8, SLC30A8, UNC5D, RBM45, P2RX5-TAX1BP3, TGM2, DNAJC21, TRIM40, MUCL3, TGFB1, HORMAD2, NFE2L2, TRBV20OR9-2, CD28, DNAH2, TCF7L2, AQP4-AS1, ZFP36L1, BRAF, SFTA2, JAZF1-AS1, SKIV2L, POU5F1, CXCL12, HLA-DPA2, ZGLP1, ATXN2, DNAJC3, APOE, USP8P1, AP4B1-AS1, AKR1B1, ALB, AGT, RNF5, IRF1-AS1, HCG17, SRP54, C1orf141, COL11A2P1, ACAN, MUC21, LINC02649, LINC02694, BCL2, LINC00243, SLC5A1, TRIM26BP, PAX5, PDCD1, SLC16A2, SLC12A3, SLC5A2, LRRK2, GAB3, RMI2, VWA7, CYP21A2, GPSM3, TPO, CARD9, SIRPG-AS1, LY6G6E, CTLA4, EFL1, CSNK2B, COX1, ANKRD55, EHMT1, RNF39, COX3, LINC01250, HPSE2, CYP27B1, PSMB8-AS1, TTC7A, DPP4, MECP2, VEGFA, VDR, VARS2, ZMIZ1, C6orf47, TSBP1-AS1, LY6G5B, LY6G6D, IL21, EDA2R, ACE, LINC00993, SLC44A4, MST1, TRNE, INSM2, TRNS2, TRNS1, TRNQ, TRNL1, SGF29, TRNH, ANKRD30A, TRNF, CLCNKB, CLN3, ND6, NKD1, ND5, FKRP, PRRT1, ND4, OR5V1, OR12D3, LY6G5C, COL1A2, LY6G6C, ITCH, LINC01193, HLA-DOA, WFS1, SH2D1A, DPT, PON1, ST3GAL4, HT, SLC2A1, TLR4, SOD2, BGLAP, ICOS, PIK3CD, TNFRSF11B, CXCR3, IL4R, ERVK-18, TP53, TNFSF10, PTEN, ADA, PIK3CA, LPA, PIK3CG, PIK3CB, CD40, TIMP1, SOD1, CCL2, HSPA4, IDDM8, TLR2, IL7, SLC2A4, IL1RN, TXNIP, PTGS2, CD14, CCR2, ESR1, IL22, HIF1A, CTNNB1, GFAP, KIR2DS1, POMC, RENBP, FOXO1, TCF7, IDDM4, REG1A, DCN, OAS1, PPARG, CYBA, NLRP3, GC, KIR3DL2, TG, TNFSF11, CYP2R1, SERPINA1, LINC02605, ITGAM, C4B, GCGR, DEXI, KRT20, RCBTB1, SLC2A2, TLR3, AVP, CXCL8, SOX13, GOLGA6A, IL15, GDF5, IDDM13, HSP90AA1, MOK, SOST, MS4A1, IL23A, HSPD1, IDDM7, LCN2, CYP24A1, NUDT10, NLRP1, DMD, BEST1, SOCS1, MIR155, SLC14A1, MIR146A, TADA1, TNFRSF9, SNCA, CD80, MTHFR, NFKB1, RAPGEF5, SPP1, IRS1, FN1, LCK, CHRM3, PDLIM7, MBL3P, NPY, GZMB, LAD1, PTPRU, ACTB, SELE, HLA-DRB5, MIR21, HOTAIR, MAFD2, HSPA5, GSTM1, HLA-DRB4, TNFRSF1A, TNFRSF1B, HBA1, ADAMTS5, HLA-DRB3, TRPC6, IDDM6, IDDM3, WG, EGF, TXN, HLA-G, SLC25A3, IL12A, MIR222, MIR34A, THY1, FAS, FOXD3, HAVCR1, IL2RB, APCS, CSN2, HMGB1, GCLC, PTPRC, ACE2, GLO1, VTCN1, DBP, CREM, TJP1, TRAF6, TNFAIP3, FCRL3, CTSC, CHGA, CST3, CISH, COL9A3, CPE, MPO, SERPINE1, CAPSL, CD36, PLXNA2, PML, APC, ANXA1, ANPEP, AMD1P2, MAPK1, AMD1, S100B, ALOX15, C4B_2, RPL17, AHSG, RPL17-C18orf32, ADM, LOC102723407, PERCC1, MTCO2P12, PTH, SHBG, APP, MIR15A, STAT5B, CD34, CD86, TRB, CD19, NHS, HNF1B, CALD1, TBP, STAT5A, MIR126, C4A, TSPO, BTF3P11, BMP2, CXCR5, UCP2, BDNF, MIR125A, CIITA, HRAS, UMOD, HSPA14, SPATA2, IDO1, GDF15, MTOR, FOS, IRF1, IRF7, FOXM1, KL, CD163, TBX21, FCGR3B, NR1I2, HDAC3, KIR2DL2, IL18RAP, TNFRSF11A, ACAD8, IL9, PRPF31, IFNA2, HMOX1, HSPA1A, HPSE, PRSS16, HGF, IDDM11, IDDM15, DKK1, CBLIF, TAB2, GPX4, IGFBP1, IGFBP3, GPT, IGHG3, TPGS2, DLK1, IRF5, TRPV1, RETN, LRP5, IL17D, DPYD, MYDGF, EDNRA, ARNTL2, CELA1, LPL, MIR494, SIRT3, MIR375, USE1, NAMPT, FTO, XYLT1, IL18BP, SELP, GDE1, TNFAIP6, CD2AP, CCL5, ZAP70, MIR326, WDR11, DGCR2, NR1D2, ATP2C1, MIR210, SLC2A3, TSPAN7, TAF5L, CELA3A, CCL3, CCL4, MEPE, TNFSF13B, TRIB3, CXCR6, DEAF1, UPK3B, NFAT5, YAP1, TUBB4B, EBNA1BP2, PLAAT4, RBP4, LANCL1, TNFRSF4, MIR204, RGS1, CLIP2, LINC01672, SLC7A9, CLIP1, S100A12, RABEPK, DDX39A, YES1, SRL, NOD2, COBL, CHDH, HPGDS, MIR20A, NR4A3, ARMH1, SOCS3, PCSK9, SELENBP1, IL33, HFM1, TREM1, TAS2R13, CDK5R1, PROM1, TLR1, NRP1, IL18R1, TSPAN33, RASSF7, CDCA5, ADIPOR1, IDDM17, TGFBI, TP63, SLCO6A1, THBS1, CDR3, TLR8, ISYNA1, SIRT6, NOX4, CNDP1, TNFRSF13C, SOD3, TRBV20-1, TRBV16, MIR132, SLC22A3, SLC22A2, SLC22A4, TRBV7-9, MIR127, SOAT1, TRBC1, ZC3H12A, NCR1, SOX9, ZFP57, SLC19A3, CD101, TUG1, SPRR2A, UCP1, GSTK1, CCHCR1, SIAE, PLA2G7, MSC, IL32, ARHGEF2, ACKR3, H3P28, PTPN1, KLRD1, RUNX2, RUNX1, LBR, CD1D, RPSA, CD3E, CD4, CD27, ENTPD1, LRP1, CD59, KIR3DS1, FCGRT, KIR2DL3, KIR2DL1, KIF5A, KDR, JAK2, LPP, LRP6, CETP, MMP3, APOA1, NFKBIA, MYO9B, ATP4A, B2M, MNAT1, MMP13, MMP9, MMP1, MAP6, BCL2A1, BMP6, MIF, BTC, MEFV, CALCA, MCL1, CALCR, CDKN2A, ITGB7, P2RX7, GCHFR, HBA2, SARDH, DNTT, GPR183, EIF5A, ENG, ENPEP, GLA, ERN1, DHCR7, ESR2, EZH2, G6PC, FYN, GAST, FAT1, FBN1, FCGR3A, HCCS, DEFB1, CCR6, IFN1@, INPP5D, COL1A1, IL6R, IL3, IGH, IGFBP5, IGF1R, CSF2, IDE, HHEX, HSPG2, HSPA2, HSPA1B, HSD11B1, CYBB, CYP2E1, DDOST, DECR1, OXA1L, FCN2, PFKFB3, ADAM10, ACR, PROC, ALOX5, AMY2A, ACTN4, ALOX12, ADRB2, PPARA, ADORA1, PSMD7, AGTR2, AKT1, PCSK1, REG3A, PRKCSH, PRKCB, CUX1, SMOC1, UGDH-AS1, NQO1, CYP2D6, XYLT2, ADORA2A, DHPS, CYP7A1, CTSV, ROBO3, NSD1, CTSL, GORASP1, WDR13, DIAPH2, ERVK-6, GAS5, ADD1, KIR2DL5A, DES, GBA3, STIM2, ZNF410, CFAP97, DEFB4A, SEMA6A, ADD2, DEFA1, ADH5, ADCY3, AICDA, LGR6, LINC-ROR, DAXX, LOC102723971, CYP27A1, PLEKHA1, PLF, IPPK, CRK, CRYZ, FHOD3, AGA, PNPLA3, CRYGD, PDCD1LG2, CD276, CRYAB, AKT2, LINC00958, IL25, CREBBP, CR1, COL11A2, COL4A2, SPX, SETD7, COL2A1, TXNDC5, CNR1, KLRC4-KLRK1, POF1B, PIP4K2C, CSF3, PINK1, DLAT, ERVK-15, UBE2Z, PARP1, GGCT, CTSG, CTSB, ADRA1A, CTRL, OR5H5P, MUL1, ADIPOR2, CCN2, NLRX1, VCAN, ADRA2B, CSK, SUV39H2, WNK1, U2AF1L5, PELI1, PCBP4, F2R, F2, ARID4B, ADA2, RN7SL263P, ETS1, DUOX1, TLR9, ERRFI1, TREM2, ETFA, ESRRA, ABL1, APBB1IP, ESD, DDIT4, CST12P, ERG, LOC105379528, TET2, ERCC1, ABCA1, DINOL, F2RL1, PTK2B, TNDM1, FCGR1B, FCGR1A, FCER2, AAVS1, NDUFA13, ERVK-32, FASN, RMDN1, TUBE1, LARS1, ACSL1, CRBN, FABP2, TLR7, FABP1, KLRF1, CSAD, FABP4, NELFCD, TRPM7, ASPN, ELP6, TOR1A, CNDP2, CSGALNACT1, IL26, ADCY10, PAG1, SELENOS, S1PR1, LMO3, ANGPTL8, DSPP, SYBU, SLC26A3, SLC2A9, PANX2, DPYS, NMUR2, LOC102724971, DNAH8, PRDM10, IDDM18, EDN1, STAP2, CASZ1, QRSL1, SARS2, EPO, BANK1, EPHB4, SLC52A1, MTPAP, RMDN3, ACTG1, KIRREL1, ENO2, MIOX, GIMAP4, ACTG2, ELF3, ELAVL2, EIF4E, EFNA1, EEF2, IL17RB, PLXNA3, ABCC2, CCR8, FAM167A, LTB4R, LOC390714, BLK, BCR, TNFRSF17, MIR487A, MIR486-1, ANXA11, BCAT1, MIR432, BAK1, BAD, MIR202, MIR409, SCGB1D4, CIMT, MIRLET7G, BAAT, ATP7A, MIR130B, ATP6V1E1, MIR136, C1QTNF8, MAFA, POTEM, CA5A, MIR449B, STPG4, SLC9C1, RNF180, SLC25A20, CELIAC2, MMAB, C1QTNF9, DDR1, VWA2, RTL1, CA2, ACTBL2, VPS51, H3P44, C3, NCF1, BRS3, ANXA5, THEMIS, MIR141, MIR142, MIR143, AQP7, MIR27A, MIR29A, MIR30D, MIR31, AQP9, MIR34C, MIR93, MIR96, MIR17HG, AQP3, MIR221, PSG8, APRT, POTEKP, APOA4, OR14J1, ANXA13, MIR328, AOC2, MIR338, AR, MIR216A, MIR145, MIR15B, KIR2DL5B, MIR148A, MIR149, MIR424, MIR150, MIR152, MIR154, ATIC, ATF3, MIR17, ARG2, MIR192, MIR377, MIR193A, MIR195, MIR197, ATD, SERPINC1, MIR206, ARNTL, LYPD5, MIR573, GSDMA, CDK2, CEACAM5, CDX2, CD52, CDKN2B, DEFB4B, KIR3DL3, CDKN1B, APOA5, LEAP2, TAGAP, MIR3150A, CDH13, CDC25C, LRBA, ADAD1, CD74, MIR1225, TRAP, KIR2DS2, SOD2-OT1, ALDH3A2, IL17F, ALOX15B, RBM17, CDCA7, TARP, ASCC2, ZCCHC7, ALDH2, GPT2, CCR4, HAVCR2, ORAI1, ABCC11, PRRT2, CCR3, TSLP, CEACAM21, MCU, CCR1, CHAT, UBXN11, MFSD4B, PRDM6, FAM83H-AS1, CD48, MIR589, DEFA1B, ARID2, KRT8P3, CCNY, PI16, RNASEH1, POTEF, CAV2, NPB, CAV1, ANGPT2, CBR1, MIR640, COPD, SEC14L3, CASP8, CASP1, MIR625, LINC00641, NPW, PGP, SERPINA6, CCK, CD44, EFHB, TNFSF8, DOCK11, MIR885, TNFRSF8, CACUL1, MIR665, AMPD1, CD247, RMDN2, BTLA, CD1A, SLC2A12, CBLL2, SLC35G1, SLC5A8, CD3D, LINC00917, GIMAP7, ANGPT1, OIP5-AS1, CD63, IGHV3OR16-7, IL21R, TM7SF2, MNDA, MMP12, MMP10, TP53BP1, TRP-TGG3-1, TRPC3, MME, TSHR, TTC3, TTC4, TTR, KMT2A, MLH1, CXCL9, U2AF1, UBC, UBE2G1, UBE2I, SUMO1, MGAT5, MGAT1, UCP3, MFGE8, MPP1, MYO1B, KIR2DS4, CYTB, NGFR, NGF, NFKBIL1, TRA, NFKB2, TRG, TRGC1, TFRC, NFATC2, NF2, NEFL, NCAM1, MYD88, THBS2, MYC, MUC1, TIMP2, TIMP3, TRNT, TKT, MTRR, MTTP, NUDT1, MFAP4, VCAM1, MFAP1, MET, MADCAM1, LDHC, F8A1, AXIN2, LAIR1, PLA2G6, DOC2B, CUL4B, CUL4A, CILP, PIK3R3, LAG3, KRT18, KRT8, RNASET2, AOC3, KNG1, PDE5A, TNFRSF25, KLRC3, RIPK2, FADD, TNFRSF18, LEPR, KMT2D, PDHX, MAS1, VEGFC, VIL1, VIM, MAP3K1, MEF2A, WARS1, MDM4, XBP1, XDH, MC4R, NPHS2, LGALS1, ALMS1, SMAD7, MXD1, LIPC, LIF, AIMP2, LHCGR, LGALS3BP, CUBN, PROA, NM, NOTCH2, NOTCH3, SCG5, RXRB, S100A1, S100A8, MAPK8, MAPK7, SARS1, SAT1, MAPK3, SCD, SCO1, PRKCA, CCL3L1, PRKAB1, PRKAA2, CCL8, PRKAA1, PREP, CCL21, SDC2, PPBP, SEL1L, PPARD, POLE, PRL, RPS6KB1, HTRA1, OPN1LW, PSMD12, PSMD8, PVT1, RAC2, RAD51, PSMC6, RAG2, RARB, PSMB5, PSMA6, PSMA3, ROS1, REG1B, RELA, RELB, PSG7, PSG2, PSG1, RGS2, RIT2, RMRP, PRTN3, SRSF5, PLIN1, NOVA1, PLEK, PAEP, P4HB, SST, SSTR4, ORM1, OAS3, NTS, NTRK2, NRAS, STAT6, SULT1E1, STIM1, NPY2R, NPPC, SUV39H1, SYT1, TAC1, TAC3, ADAM17, NPPA, NPHS1, TAPBP, TAT, SPARC, SP3, SOX2, PF4V1, PMEL, PLG, PLAU, PKD1, PI3, PHB, ABCB1, SLC6A6, SERPINA3, CFP, PF4, PRKN, PER1, SERPINF1, PDR, ENPP1, SLC22A5, SUMO2, PDCD2, FSCN1, PCMT1, PAX6, KISS1, KAT2B, FGB, CXCL1, GRN, GRB10, GPX3, ANKS1A, ICOSLG, GPX1, ZDHHC17, SIRT5, FFAR2, GPR42, XCR1, CELA3B, GPI, DDAH2, PADI4, DDAH1, DDX58, GNB3, CA14, SNHG1, PPIL2, IL17RA, PANX1, NR3C1, MLC1, KCNQ1, PMPCA, BTN3A2, FAF1, HCRT, NUDT3, SLC2A6, POLG2, USP18, HARS1, ACOT7, IKZF3, H2AX, CARD8, KLRK1, MMRN1, SIRT2, GYS1, TPX2, GSTM2, GSR, GSN, MCF2L2, GSK3B, NCDN, QPCT, LMOD1, PART1, GLB1, DESI1, PTGER4, IGHV3-69-1, FYB1, TRBV2, TRAV29DV5, TRAJ60, TRAC, FPR3, FLVCR1, FPR2, FMR1, FOXO3, FOXF1, NENF, FGR, SLC2A8, FGF14, FGF3, CD209, FGF2, DUOX2, FGF1, PCSK1N, SLC37A4, PDCD4, GCKR, RNF19A, SOSTDC1, GORASP2, APPL1, POLDIP2, B4GALT1, NOC2L, GFER, MSTN, OR7E66P, GATA4, IL17B, GALNT3, UTP25, SND1, FOXP1, B3GAT1, B4GALNT1, DKK4, NAAA, IL37, IL17C, CIT, HFE, CFHR2, IL5, GRAP2, NTN1, ABCG2, INSRR, INPPL1, FHL5, CHST3, ATG5, STX8, ADAMTS4, ADAMTS3, ADAMTS1, GAL3ST1, IL15RA, SOCS5, CEP135, SART3, IL13RA1, IL12RB2, ELMO1, PUM3, ARHGAP25, MVP, IRAK1, NRXN1, ITGA2B, IVL, KCNJ3, KCNE1, APLN, SPHK1, HERC2, KCNC4, HSPB3, JUN, MAP3K14, JAK1, HGS, ITGA4, SCAF11, LPAR2, IL1RL1, XPR1, ITGB3, ITGB2, ITGB1, STK17B, ITGAX, ITGAL, IL12RB1, ABCB6, SDS, DNM1L, SLC19A2, AHSA1, SLCO1B1, HES1, IGF2BP2, HPRT1, HOXD8, HNRNPK, HNRNPF, HMGCS2, OGA, HLA-E, YME1L1, PHTF1, MASP2, NES, CCL27, HK2, LILRB1, HK1, PPARGC1A, NRG1, KCNQ1OT1, SLC35A1, HSD17B4, PRDX4, RAMP2, IGHM, TSPAN5, IGF2R, EBI3, ALYREF, IFNW1, IFNB1, OLIG2, KLRG1, IFNA17, ID3, BATF, SIGMAR1, ID2, IRF8, AKR1A1, TLR6, HTR1A, CEPT1, NOD1, HSPE1, UNC13B, NAT2
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Near-Sightedness
Wikipedia
So, if diameter is smaller or thickness is greater, resulting myopia correction will be greater. [80] Alternative medicine [ edit ] A number of alternative therapies have been claimed to improve myopia, including vision therapy , "behavioural optometry", various eye exercises and relaxation techniques, and the Bates method . [81] Scientific reviews have concluded that there was "no clear scientific evidence" that eye exercises are effective in treating near-sightedness [82] and as such they "cannot be advocated". [83] Epidemiology [ edit ] Global refractive errors have been estimated to affect 800 million to 2.3 billion. [84] The incidence of myopia within sampled population often varies with age, country, sex, race , ethnicity , occupation, environment, and other factors. [85] [86] Variability in testing and data collection methods makes comparisons of prevalence and progression difficult. [87] The prevalence of myopia has been reported as high as 70–90% in some Asian countries, 30–40% in Europe and the United States, and 10–20% in Africa. [86] Myopia is about twice as common in Jewish people than in people of non-Jewish ethnicity. [88] Myopia is less common in African people and associated diaspora. [85] In Americans between the ages of 12 and 54, myopia has been found to affect African Americans less than Caucasians. [89] Asia [ edit ] Estimated myopia rate in 20-year-olds in Asia. [90] In some parts of Asia , myopia is very common. Singapore is believed to have the highest prevalence of myopia in the world; up to 80% of people there have myopia, but the accurate figure is unknown. [91] China 's myopia rate is 31%: 400 million of its 1.3 billion people are myopic. The prevalence of myopia in high school in China is 77%, and in college is more than 80%. [92] In some areas, such as China and Malaysia , up to 41% of the adult population is myopic to 1.00 dpt, [93] and up to 80% to 0.5 dpt. [94] A study of Jordanian adults aged 17 to 40 found over half (54%) were myopic. [95] Some research suggests the prevalence of myopia in India children is less than 15%. [96] Europe [ edit ] Myopia rate in Europe by birth decade (1910 to 1970). [97] In first-year undergraduate students in the United Kingdom 50% of British whites and 53% of British Asians were myopic. [98] A recent review found 27% of Western Europeans aged 40 or over have at least −1.00 diopters of myopia and 5% have at least −5.00 diopters. [99] North America [ edit ] Myopia is common in the United States , with research suggesting this condition has increased dramatically in recent decades. ... Clinical & Experimental Optometry (Review). 98 (6): 497–506. doi : 10.1111/cxo.12346 . ... The British Journal of Ophthalmology . 86 (11): 1306–11. doi : 10.1136/bjo.86.11.1306 .PRSS56, RASGRF1, COL2A1, SCO2, LAMA2, RDH5, KCNQ5, GRIA4, COL9A1, GJD2, BMP2, LRPAP1, P3H2, SIX6, IRX5, ADORA2A, IGF1, RPGR, FBN1, NYX, CACNA1F, BMP3, COL1A1, COL18A1, IFT43, ADAMTS2, BFSP2, CTNNB1, GRM6, CRYAA, COL11A1, RBFOX1, RP2, LAMA1, TYR, BMP4, SHISA6, STRN4, PUF60, IQSEC2, MBTPS2, EMC1, ZNF292, NT5C2, POLR3A, CPSF2, NDUFB11, PRDM5, KDM5B, MAGEL2, RAI1, GTPBP2, YME1L1, WAC, PACS2, POGZ, EXOC6B, POMT2, ANKRD11, CLDN16, SMARCAL1, SH2B1, NTM, PDE11A, TRNT1, IFT52, WHRN, NIPBL, KCNE5, ATP6V0A2, EXOSC2, GMPPB, TBL2, ACOX1, POMT1, TTN, RBM10, USP9X, RNF113A, CLIP2, VARS1, USH2A, UBE3A, TULP1, TUB, THRB, DEAF1, TGFBR1, TFAP2B, TFAP2A, TEAD1, TCF20, TCF7L2, TCF4, TAF1, STIM1, KDM5C, SMC1A, CDC45, ELP1, SEC23B, OPTN, HUWE1, SLC12A6, AMMECR1, KIAA0586, P4HTM, GTF2IRD1, TJP2, RECQL4, LARGE1, SMC3, BAZ1B, PLOD3, GPAA1, EED, CDK13, SLC25A12, CASK, TMEM94, POMGNT1, TRIT1, UBE3B, DNAJC21, B3GALT6, CANT1, TWIST2, C12orf57, CHST14, ADAMTSL1, PXYLP1, CCNQ, PTPN5, FRMPD2, LOXL3, ZNF469, GNPTG, TRAF7, POMK, ANTXR1, ADGRV1, TSPAN10, APH1B, MPLKIP, B3GLCT, TRIM8, SLC39A5, TTN-AS1, LINC00989, KLLN, LINC00862, GPR179, GTF2H5, BLOC1S3, LRIT3, FLG-AS1, ZBTB38, LRFN5, NT5DC1, PRIMPOL, ASXL1, ADAMTS17, KCNV2, VPS13B, C8orf37, CLDN19, B3GALNT2, CDCA3, SLC2A10, NDE1, POLR3B, ARID1B, TBC1D24, DSCAML1, GJC2, KLHL7, HDAC8, MBD5, IFT122, AGK, PACS1, WDR35, NPLOC4, CHD7, SON, FANCI, ATAD3A, SETD5, FKBP14, PHIP, NSUN2, HACE1, ZSWIM6, BICC1, CCDC28B, PDZD7, CSPP1, EHMT1, ZNF408, ZMAT4, EFL1, OR7E94P, THOC6, FKRP, RSRC2, LRRC4C, BCL11B, NSD1, IRF2BPL, IFIH1, XYLT2, XYLT1, TRAPPC11, AGBL5, WDR19, SOX5, UCHL1, NFIA, MC1R, COL5A1, COL5A2, TRPM1, COL6A1, KMT2A, MECP2, COL9A2, MAF, CHMP1A, COL9A3, LTBP2, LRP2, COL10A1, LIMK1, LIG4, LAMB2, COL4A5, COL4A4, COL4A3, MYH11, PAX2, CBS, CHM, OCA2, OAT, GPR143, NTRK2, NRAS, NOTCH2, NONO, COL4A1, MYOC, MYO7A, MYO5B, MYO5A, COL11A2, KRAS, KIF11, GNB3, GLE1, GJA8, GJA1, OPN1MW, EIF2S3, MTOR, EPHA2, FLII, FLG, ELN, ERCC2, ERCC3, FKTN, FBN2, BPTF, GLRB, GPD2, CRYBA4, GTF2E2, CRYBB1, KCNMA1, KCNH1, CRYBB2, CRYGC, CRYGD, VCAN, HSPG2, DAG1, HTT, TIMM8A, HADHA, DLG2, GTF2I, DPYD, PAX6, ACSL4, PCYT1A, SDHC, PPP2R5D, ARCN1, ABCC6, MAP2K1, MAP2K2, SLC25A4, PSMD12, RPL10, PTEN, PTPN11, RP1, ALDH18A1, CAMK2G, PZP, RAD21, RAD51, RMRP, ALDH3A2, OPN1LW, RFC2, RGR, SDHB, AKT1, PMM2, PIK3R1, ATRX, JAG1, FXYD2, PIK3CA, BRAF, SKI, SDHD, BTD, ENPP1, PLOD1, BBS1, SIM1, MYP2, PLXNA2, MMP2, MYP3, TGFB1, TMTC3, CREBZF, VDR, FGF10, LUM, MYP10, TIMP2, ALOX5AP, CTNND2, TGFB2, HGF, EGR1, CFH, MYP12, ZC3H11B, FGF2, SNTB1, AMD1, MMP1, MYP1, COL8A1, AMD1P2, VIP, APLP2, MIR328, MMP9, WNT7B, VIPR2, MYP15, BIRC6-AS1, MYP16, CCDC102B, ADRA1D, H3P24, MYP14, TTC21B, DRD1, MYP7, MIR582, DCN, OVAAL, BBS4, CHRM2, CHRM3, ADAMTS18, SIRPA, ERG, PLK3, ARNTL, LYPLAL1, IL27, RHOA, AREG, AQP1, HS6ST2, MIR184, UMODL1, MIR29A, SLITRK6, MINDY4, ZNF644, ARL6, CTSH, SOX2, JUND, PDIA2, PIK3CG, PRS, PRKAR2B, HERC2, P4HA2, CDKL2, PPARA, GSTO1, ROCK2, GOSR1, PSMC1, LPIN2, SERPINI2, SERPINF1, ZEB2, ZC3H11A, THOC1, BCAP31, P4HB, HTRA1, PSMD10, NT5E, TIMP3, SP1, SRC, STAR, STAT3, DYNLT3, RPE, TGIF1, RLF, PHLDA2, PTGFR, RARB, RARA, RAD51B, VEGFA, WNT2B, DNALI1, FZD5, RAD1, OTC, KERA, GMCL2, HAS2, IFIT1, CFI, CCDC91, SLC30A10, BMP2K, HPV18I2, HOXA9, HIF1A, GYPA, IL10, CABP4, GLUL, GCLC, GC, GAD1, FOSB, FOS, GMCL1, IGF1R, JUN, WDHD1, CHMP4A, MAPRE3, DKK1, MMP11, MMP8, GCA, MMP3, PTPN23, SENP6, MET, JUNB, PADI1, RDH8, TMED5, LRP1, LOX, LAMA5, KIT, PPP1R12C, H3P45
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Septic Arthritis
Wikipedia
Synovial fluid cultures will be positive in 80% of the cases. However, acid fast smears are not useful. ... PMID 21961455 . ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap aq ar as at au av aw ax ay az ba bb bc bd be bf bg bh bi bj bk bl bm bn bo bp bq br bs bt bu bv bw bx Horowitz, DL; Katzap, E; Horowitz, S; Barilla-LaBarca, ML (15 September 2011). ... Academic Emergency Medicine . 18 (8): 781–96. doi : 10.1111/j.1553-2712.2011.01121.x . ... PMID 17405973 . ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap Goldberg, D.L.; Sexton, D.J. (2017). ... Implications for treatment". J. Bone Joint Surg. Br . 80 (3): 471–3. doi : 10.1302/0301-620X.80B3.8296 .
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The Great Imitator
Wikipedia
American Journal of Clinical Dermatology . 7 (6): 375–82. doi : 10.2165/00128071-200607060-00006 . ... The American Journal of Medicine . 123 (7): e5. doi : 10.1016/j.amjmed.2009.12.027 .
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Concussion
Wikipedia
However, the definition has evolved over time to include a change in consciousness, such as amnesia, [80] although controversy continues about whether the definition should include only those injuries in which loss of consciousness occurs. [41] This debate resurfaces in some of the best-known concussion grading scales, in which those episodes involving loss of consciousness are graded as being more severe than those without. [81] Definitions of mild traumatic brain injury (mTBI) were inconsistent until the World Health Organization 's International Statistical Classification of Diseases and Related Health Problems (ICD-10) provided a consistent, authoritative definition across specialties in 1992. [82] Since then, various organizations such as the American Congress of Rehabilitation Medicine [21] and the American Psychiatric Association in its Diagnostic and Statistical Manual of Mental Disorders [82] have defined mTBI using some combination of loss of consciousness (LOC), post-traumatic amnesia (PTA), and the Glasgow Coma Scale (GCS). Concussion falls under the classification of mild TBI, [83] but it is not clear whether concussion is implied in mild brain injury or mild head injury. [84] [ needs update ] "mTBI" and "concussion" are often treated as synonyms in medical literature [21] but other injuries such as intracranial hemorrhages (e.g. intra-axial hematoma , epidural hematoma , and subdural hematoma ) are not necessarily precluded in mTBI [38] or mild head injury, [85] [86] as they are in concussion. [87] mTBI associated with abnormal neuroimaging may be considered "complicated mTBI". [47] "Concussion" can be considered to imply a state in which brain function is temporarily impaired and "mTBI" to imply a pathophysiological state, but in practice, few researchers and clinicians distinguish between the terms. [38] Descriptions of the condition, including the severity and the area of the brain affected, are now used more often than "concussion" in clinical neurology. [88] Prevention Main article: Prevention of concussions Prevention of mTBI involves general measures such as wearing seat belts , using airbags in cars, and protective equipment such as helmets for high-risk sports. [21] [89] Older people are encouraged to reduce fall risk by keeping floors free of clutter and wearing thin, flat, shoes with hard soles that do not interfere with balance. [31] Protective equipment such as helmets and other headgear and policy changes such as the banning of body checking in youth hockey leagues have been found to reduce the number and severity of concussions in athletes. [90] Secondary prevention such as a Return to Play Protocol for an athlete may reduce the risk of repeat concussions. [91] New "Head Impact Telemetry System" technology is being placed in helmets to study injury mechanisms and may generate knowledge that will potentially help reduce the risk of concussions among American Football players. [ citation needed ] Educational interventions, such as handouts, videos, workshops, and lectures, can improve concussion knowledge of diverse groups, particularly youth athletes and coaches. [92] Strong concussion knowledge may be associated with greater recognition of concussion symptoms, higher rates of concussion reporting behaviors, and reduced body checking-related penalties and injuries, thereby lowering risk of mTBI. [92] Due to the incidence of concussion in sport, younger athletes often do not disclose concussions and their symptoms. ... If repeated vomiting, worsening headache, dizziness, seizure activity, excessive drowsiness, double vision, slurred speech, unsteady walk, or weakness or numbness in arms or legs, or signs of basilar skull fracture develop, immediate assessment in an emergency department is needed. [93] [11] Observation to monitor for worsening condition is an important part of treatment. [12] People may be released after assessment from their primary care medical clinic, hospital, or emergency room to the care of a trusted person with instructions to return if they display worsening symptoms or those that might indicate an emergent condition ("red flag symptoms") such as change in consciousness, convulsions, severe headache, extremity weakness, vomiting, new bleeding or deafness in either or both ears. [94] [57] [12] Education about symptoms, their management, and their normal time course, may lead to an improved outcome. [77] [ needs update ] Rest and return to physical and cognitive activity Physical and cognitive rest is recommended for the first 24–48 hours following a concussion after which injured persons should gradually start gentle low-risk physical and cognitive activities that do not make current symptoms worse or bring on new symptoms. [10] [95] Any activity for which there is a risk of contact, falling, or bumping the head should be avoided. [10] Low-risk activities can be started even while a person has symptoms, as long as the activity does not worsen existing symptoms or bring on new concussion symptoms. [57] [13] Resting for longer than 24-48 hours follow concussion has been shown to be associated with longer recovery. [96] Return-to-school The resumption of low-risk school activities should begin as soon as the student feels ready and has completed an initial period of cognitive rest of no more than 24–48 hours following the acute injury. [96] [97] Long absences from school are not suggested, however, the return to school should be gradual and step-wise. [97] Prolonged complete mental or physical rest (beyond 24–48 hours after the accident that lead to the concussion) may worsen outcomes, [97] however, rushing back to school before the person is ready, has also been associated with longer-lasting symptoms and an extended recovery time. [98] Student's with a suspected concussion are required to see a doctor for an initial medical assessment and for suggestions on recovery, however, medical clearance is not required for a student to return to school. [57] Since students may appear 'normal', continuing education of relevant school personnel may be needed to ensure appropriate accommodations are made such as part-days and extended deadlines. [96] Accommodations should be based on the monitoring of symptoms that are present during the return-to-school transition including headaches, dizziness, vision problems, memory loss, difficulty concentrating, and abnormal behavior. [96] [98] Students must have completely resumed their school activities (without requiring concussion-related academic supports) before returning to full-contact sports. [57] Return-to-sport For persons participating in athletics, it is suggested that participants progress through a series of graded steps. [10] These steps include: Immediately after injury: 24-48 hours (maximum) of relative physical and cognitive rest. [10] Stage 1: Gentle daily activities such as walking in the house, gentle housework, and light school work that do not make symptoms worse. ... A World Health Organization (WHO) study estimated that between 70 and 90% of head injuries that receive treatment are mild. [3] However, due to under reporting and to the widely varying definitions of concussion and mTBI, it is difficult to estimate how common the condition is. [82] Estimates of the incidence of concussion may be artificially low, for example, due to under reporting. ... People without brain injury will be able to track the moving object with smooth pursuit eye movements and correct trajectory while it is hypothesized that those with mild traumatic brain injury cannot. [136] Grading systems Main article: Concussion grading systems At least 41 systems measure the severity, or grade, of a mild head injury, [38] and there is little agreement about which is best. [23] In an effort to simplify, the 2nd International Conference on Concussion in Sport, meeting in Prague in 2004, decided that these systems should be abandoned in favor of a 'simple' or 'complex' classification. [137] However, the 2008 meeting in Zurich abandoned the simple versus complex terminology, although the participants did agree to keep the concept that most (80–90%) concussions resolve in a short period (7–10 days) and although the recovery time frame may be longer in children and adolescents. [93] [ needs update ] In the past, the decision to allow athletes to return to participation was frequently based on the grade of concussion. [ citation needed ] However, current research and recommendations by professional organizations including the National Athletic Trainers' Association recommend against such use of these grading systems. [ citation needed ] Currently, injured athletes are prohibited from returning to play before they are symptom-free during both rest and exertion and until results of the neuropsychological tests have returned to pre-injury levels. [ citation needed ] Three grading systems have been most widely followed: by Robert Cantu, the Colorado Medical Society , and the American Academy of Neurology . [81] Each employs three grades, as summarized in the following table: [23] Comparison of historic concussion grading scales – not currently recommended for use by medical professionals Guidelines Grade I Grade II Grade III Cantu Post-traumatic amnesia <30 minutes, no loss of consciousness Loss of consciousness <5 minutes or amnesia lasting 30 minutes–24 hours Loss of consciousness >5 minutes or amnesia >24 hours Colorado Medical Society Confusion, no loss of consciousness Confusion, post-traumatic amnesia, no loss of consciousness Any loss of consciousness American Academy of Neurology Confusion, symptoms last <15 minutes, no loss of consciousness Symptoms last >15 minutes, no loss of consciousness Loss of consciousness (IIIa, coma lasts seconds, IIIb for minutes) See also Concussions in American football Concussion in Rugby Union Head injury criterion Helmet removal (sports) References ^ a b c "What are common TBI symptoms?"
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Syphilis
Wikipedia
Now studies require informed consent , [98] communication of diagnosis , and accurate reporting of test results. [99] Preparation and Use of Guayaco for Treating Syphilis , after Stradanus , 1590 Similar experiments were carried out in Guatemala from 1946 to 1948. ... Archives of Internal Medicine . 160 (5): 585–98. doi : 10.1001/archinte.160.5.585 . ... Bulletin of the World Health Organization . 82 (6): 402–9. PMC 2622861 . PMID 15356931 . ^ U.S. ... The Lancet Infectious Diseases . 11 (9): 684–91. doi : 10.1016/S1473-3099(11)70104-9 . ... Expert Opinion on Pharmacotherapy . 6 (13): 2271–80. doi : 10.1517/14656566.6.13.2271 .
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Dementia With Lewy Bodies
Wikipedia
Tousi (2017), Diagnosis and Management of Cognitive and Behavioral Changes in Dementia With Lewy Bodies . [32] REM sleep behavior disorder (RBD) is a parasomnia in which individuals lose the paralysis of muscles (atonia) that is normal during rapid eye movement (REM) sleep , and consequently act out their dreams or make other abnormal movements or vocalizations. [33] About 80% of those with DLB have RBD. [34] Abnormal sleep behaviors may begin before cognitive decline is observed, [24] and may appear decades before any other symptoms, often as the first clinical indication of DLB and an early sign of a synucleinopathy. [35] On autopsy, 94 to 98% of individuals with polysomnography -confirmed RBD have a synucleinopathy—most commonly DLB or Parkinson's disease [36] [37] in about equal proportions. [38] More than three out of four people with RBD are diagnosed with a neurodegenerative condition within ten years, [39] but additional neurodegenerative diagnoses may emerge up to 50 years after RBD diagnosis. [37] RBD may subside over time. [24] Individuals with RBD may not be aware that they act out their dreams. [40] RBD behaviors may include yelling, screaming, laughing, crying, unintelligible talking, nonviolent flailing, or more violent punching, kicking, choking, or scratching. [41] [42] The reported dream enactment behaviors are frequently violent, [43] and involve a theme of being chased or attacked. [36] People with RBD may fall out of bed or injure themselves or their bed partners, [24] [36] [42] which may cause bruises, fractures, or subdural hematomae . [44] Because people are more likely to remember or report violent dreams and behaviors—and to be referred to a specialist when injury occurs— recall or selection bias may explain the prevalence of violence reported in RBD. [45] Parkinsonism [ edit ] Parkinsonism is a clinical syndrome characterized by slowness of movement, rigidity, postural instability , and tremor ; [46] [47] it is found in DLB and many other conditions like Parkinson's disease, Parkinson's disease dementia, and others. [47] Parkinsonism occurs in more than 85% of people with DLB, who may have one or more of these cardinal features, [24] although tremor at rest is less common. [48] Motor symptoms may include shuffling gait , problems with balance, falls , blank expression, reduced range of facial expression, and low speech volume or a weak voice . [2] Presentation of motor symptoms is variable, but they are usually symmetric, presenting on both sides of the body. [49] Only one of the cardinal symptoms of parkinsonism may be present, [1] and the symptoms may be less severe than in persons with Parkinson's disease. [50] Visual hallucinations [ edit ] Up to 80% of people with DLB have visual hallucinations, typically early in the course of the disease. [24] [51] They are recurrent and frequent; may be scenic, elaborate and detailed; [52] and usually involve animated perceptions of animals or people, including children and family members. [5] Examples of visual hallucinations "vary from 'little people' who casually walk around the house, 'ghosts' of dead parents who sit quietly at the bedside, to 'bicycles' that hang off of trees in the back yard". [53] These hallucinations can sometimes provoke fear, although their content is more typically neutral. [5] In some cases, the person with DLB may have insight that the hallucinations are not real. [54] Among those with more disrupted cognition, the hallucinations can become more complex, and they may be less aware that their hallucinations are not real. [55] Visual misperceptions or illusions are also common in DLB but differ from visual hallucinations. ... Variants of this protein influence the risk of developing DLB. [78] Like other synucleinopathies, [79] the exact cause of DLB is unknown. [80] Synucleinopathies are typically caused by interactions of genetic and environmental influences. [79] Most people with DLB do not have affected family members, although occasionally DLB runs in a family. [4] The heritability of DLB is thought to be around 30% (that is, about 70% of traits associated with DLB are not inherited). [81] There is overlap in the genetic risk factors for DLB, Alzheimer's disease (AD), Parkinson's disease, and Parkinson's disease dementia. [78] [82] The APOE gene has three common variants. ... DLB is characterized by the development of abnormal collections of alpha-synuclein protein within diseased brain neurons, known as Lewy bodies and Lewy neurites. [78] When these clumps of protein form, neurons function less optimally and eventually die. [18] Neuronal loss in DLB leads to profound dopamine dysfunction [86] and marked cholinergic pathology; [87] other neurotransmitters might be affected, but less is known about them. [88] Damage in the brain is widespread, and affects many domains of functioning. [18] [a] Loss of acetylcholine -producing neurons is thought to account for degeneration in memory and learning, while the death of dopamine-producing neurons appears to be responsible for degeneration of behavior, cognition, mood, movement, motivation, and sleep. [2] The extent of Lewy body neuronal damage is a key determinant of dementia in the Lewy body disorders. [90] [91] The precise mechanisms contributing to DLB are not well understood and are a matter of some controversy. [92] The role of alpha-synuclein deposits is unclear, because individuals with no signs of DLB have been found on autopsy to have advanced alpha-synuclein pathology. [78] The relationship between Lewy pathology and widespread cell death is contentious. [92] It is not known if the pathology spreads between cells or follows another pattern. [93] The mechanisms that contribute to cell death, how the disease advances through the brain, and the timing of cognitive decline are all poorly understood. [92] There is no model to account for the specific neurons and brain regions that are affected. [92] Autopsy studies and amyloid imaging studies using Pittsburgh compound B (PiB) [94] indicate that tau protein pathology and amyloid plaques , [95] which are hallmarks of AD, [96] are also common in DLB [97] and more common than in Parkinson's disease dementia. [98] Amyloid-beta (Aβ) deposits are found in the tauopathies —neurodegenerative diseases characterized by neurofibrillary tangles of hyperphosphorylated tau protein [96] [99] [100] —but the mechanism underlying dementia is often mixed, and Aβ is also a factor in DLB. [101] A proposed pathophysiology for RBD implicates neurons in the reticular formation that regulate REM sleep. ... Supportive clinical features are marked sensitivity to antipsychotics; marked autonomic dysfunction; nonvisual hallucinations; hypersomnia; reduced ability to smell; false beliefs and delusions organized around a common theme; postural instability, loss of consciousness and frequent falls; and apathy, anxiety, or depression. [1] [28] Positron emission tomography , for example, using PiB is helpful in the diagnosis of DLB. [24] [94] Direct laboratory-measurable biomarkers for DLB diagnosis are not known, but several indirect methods can lend further evidence for diagnosis. [24] The indicative diagnostic biomarkers are: reduced dopamine transporter uptake in the basal ganglia shown on PET or SPECT imaging; low uptake of 123 iodine - metaiodobenzylguanidine ( 123 I-MIBG) shown on myocardial scintigraphy ; and loss of atonia during REM sleep evidenced on polysomnography.SNCA, SNCB, GBA, TH, NGF, GFAP, SOD2, ENO2, EDN1, IGF2, IGF2R, INS, PPARGC1A, NTRK1, NTRK2, INSR, MAG, BECN1, MAP2, IGF1R, AIF1, AGER, APOE, ASH1L, TARDBP, CSF2, LRRK2, LAMC2, PSEN1, MAPT, BCL7C, MIR762HG, MIR4519, BCHE, SLC6A3, CIT, CYP2D6, APP, SMUG1, SNCG, GBAP1, MCIDAS, IMPA1, BRAP, GRN, SNCAIP, PRNP, LRP10, NOS3, TPO, ACHE, BDNF, CHI3L1, CTSD, IGF1, SYNM, HSPA4, C9orf72, ACE, CYP2D7, PSMB8, SERPINA3, KLK6, PLA2G6, TSHZ1, TOMM40, SCARB2, NEFL, PRKN, NOS2, ZFPM1, GRM5, CALB1, PINK1, EIF4G1, REM1, NUB1, FYN, SPP1, MIR34B, ATG7, RIDA, DLEU1, VCAM1, UCHL3, UCHL1, KHDRBS1, OGA, UBC, PLK2, UBB, ALDH1L1, PHYHD1, NANOS3, ECE2, MIR451A, AKR7A2, MIR21, MIR133B, SUCLA2, VSNL1, SQSTM1, AD12, TFEB, PPIG, MTCO2P12, VGF, GDF15, LOC107987479, VEGFA, MYO5C, CHP1, PTCRA, BHLHE22, NBEAL1, TPSG1, CHMP2B, MOAP1, NEUROD6, TIGAR, CHORDC1, GPR78, HTRA2, TSC2, TMEM230, RMC1, GAL, CHCHD2, DCTN4, ABI3, SLC17A7, VPS13C, NUP62, MUL1, SUGT1, BPIFA2, TPPP, CBLL2, LAPTM4B, PARK7, ECD, SESN3, SYNPO, LMTK2, RPH3A, MINDY4, SMG1, KCNH8, DNAJC13, ZFPM2, RAB39B, TRIM9, KCNH4, CHRFAM7A, BACE1, A2M, TNF, DBH, DLD, DLG4, DNMT1, DRD1, DRD2, DYRK1A, ECE1, EEF1A1, EEF1B2P2, ELF3, ELK1, EPHX2, F11, FABP3, FANCD2, FGFR3, FKBP1A, FKBP1AP1, FKBP1AP2, FKBP1AP3, FKBP1AP4, DCX, CYP2B6, FUS, CTSB, GRK2, AFM, ANK1, BIRC5, AQP1, AQP4, ASAH1, BCL2, BCL2L1, BMI1, BRCA2, TSPO, CAMK2A, CAPN1, CASP2, CASP3, CHRNA4, CLU, COMT, CSF1R, CST3, FOXO1, SFN, TGFB2, SERPINB6, PLCG2, PRD, PSPN, PRSS2, MASP1, PSEN2, PSPH, PTGS2, REG1A, REST, RPS27A, S100B, SGTA, SLC1A2, SLC6A2, SLC6A4, SOD1, SP1, STXBP3, TF, TFAM, PIK3R2, SERPINA1, GRK5, PECAM1, GSN, GTF2H1, HSP90AA1, IGFALS, IL6, INSRR, ITGB2, LAD1, LAMP2, LGALS3, MAOB, MAP1A, AFF1, MMP9, MSMB, COX2, NOS1, NOTCH3, NRGN, NR4A2, PDHA1, EEF1AKMT4-ECE2
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Medical Abortion
Wikipedia
"Medical abortion in the late first trimester: a systematic review" . Contraception . 99 (2): 77–86. doi : 10.1016/j.contraception.2018.11.002 . ... "Comparing office and telephone follow-up after medical abortion" . Contraception . 94 (2): 122–126. doi : 10.1016/j.contraception.2016.04.007 . ... "First-trimester abortion in women with medical conditions" . Contraception . 86 (6): 622–630. doi : 10.1016/j.contraception.2012.09.001 . ... "Medical abortion reporting of efficacy: the MARE guidelines" . Contraception . 94 (2): 97–103. doi : 10.1016/j.contraception.2016.04.013 . ... American Journal of Obstetrics and Gynecology . 218 (3): 315.e1–315.e6. doi : 10.1016/j.ajog.2017.11.555 .
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Intermittent Explosive Disorder
Wikipedia
PMID 7544158 . ^ Best M, Williams JM, Coccaro EF (June 2002). "Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder" . Proc. Natl. Acad. Sci. U.S.A . 99 (12): 8448–53. doi : 10.1073/pnas.112604099 . ... PMID 12034876 . ^ a b c d Kessler RC, Coccaro EF, Fava M, Jaeger S, Jin R, Walters E (June 2006). ... "American Journal of Psychiatry," 169. 577-588. ^ Coccaro, EF (2000). Intermittent explosive disorder. ... Soc Psychiatry Psychiatr Epidemiol 40:681–690, 2005. ^ Coccaro EF, Posternak MA, Zimmerman M (October 2005).
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Cervical Cancer
Wikipedia
When cisplatin is present, it is thought to be the most active single agent in periodic diseases. [89] Such addition of platinum-based chemotherapy to chemoradiation seems not only to improve survival but also reduces risk of recurrence in women with early stage cervical cancer (IA2-IIA). [90] A Cochrane review found a lack of evidence on the benefits and harms of primary hysterectomy compared to primary chemoradiotherapy for cervical cancer in stage IB2. [91] Advanced-stage tumors (IIB-IVA) are treated with radiation therapy and cisplatin-based chemotherapy. ... These statistics may be improved when applied to women newly diagnosed, bearing in mind that these outcomes may be partly based on the state of treatment five years ago when the women studied were first diagnosed. [98] With treatment, 80–90% of women with stage I cancer and 60–75% of those with stage II cancer are alive 5 years after diagnosis. ... PMC 4086375 . PMID 25045355 . ^ Dunne EF, Park IU (December 2013). "HPV and HPV-associated diseases". ... American Journal of Public Health . 91 (6): 947–52. doi : 10.2105/AJPH.91.6.947 . ... European Journal of Obstetrics, Gynecology, and Reproductive Biology . 121 (1): 99–103. doi : 10.1016/j.ejogrb.2004.11.024 .FGFR3, STK11, HLA-DPB1, VEGFA, CTNNB1, EGFR, MTHFR, TERT, CCND1, HOTAIR, STAT3, HLA-DPB2, NOTCH1, MYC, CASP8, TP63, ERCC1, RARB, MTOR, JAK2, POU4F1, YY1, APOBEC3B, MIR543, ZNF667-AS1, WNT5A, CLPTM1L, MIR501, WNT2, PIAS3, BIRC5, NOTCH2, HES1, CYLD, CXCR4, HLA-DQA1, CDKN1B, EXOC1, ERBB2, H3P10, PIK3CB, XRCC1, SMUG1, HLA-DRB1, BMI1, SRY, PIK3CA, MMP9, MMP2, FHIT, VEGFC, CDKN2A, ESR1, HLA-DQB1, MALAT1, CADM1, COL11A2P1, TGFB1, EZH2, CASP3, MDM2, TLR4, TNF, FOXM1, TP53, PIK3CD, C2orf83, MIR34A, MIR21, PTEN, IFNG, IL1B, CD274, IL6, BCL2, IL10, GSTM1, TLR9, RBM45, GSTT1, CTLA4, CYP1A1, PIK3CG, PTGS2, PDXP, AKT1, HIF1A, MIR126, KRT19, IL1RN, VIM, MTDH, TP73, PAX1, FAS, MEG3, RASSF1, HPGDS, HLA-A, FOXP3, CXCL8, MIR143, MIR145, HLA-B, MIR155, MAPK1, MIR214, CCNA1, SOCS1, PCNA, CXCL12, EGF, PARP1, SP1, CDKN1A, DNMT1, NEAT1, MACC1, MIR195, MAL, MTCO2P12, MIR375, IL17A, COX2, COMMD3-BMI1, GAS5, UBE3A, PVT1, MIR146A, CCK, FGF2, EPHB2, WNK1, IGF1, RELA, MIR424, MIR205, TNFSF10, ARHGAP24, ATM, SYT1, GORASP1, SIX1, CA9, EZR, GSTK1, NFE2L2, TAFA4, IGF1R, IGF2, IL1A, LGALS1, CCR2, MAPK3, IRF1, MIR497, TACSTD2, MIR182, MIR203A, MIR20A, E2F1, HMGB1, SLCO6A1, ZEB1, SPP1, COL11A2, CDKN3, SOX9, TAP2, RAD51, SIRT1, MIR200B, LGALS3, FOXO1, TP53BP1, CIP2A, LTA, KLF5, SMAD4, CALR, XRCC3, MIR144, CD28, TIMP2, KDR, F2RL1, MIR142, MIR140, CD44, CRNDE, VTCN1, MMP1, TERC, MMP7, KRAS, TUG1, MIR206, MPO, H3P23, MIR326, MIR93, HPSE, HRAS, HGF, HSPA4, MIR31, IFI27, GSTP1, MIR361, DCTN6, SPAG5, ZNRD2, TMED7, MIR29A, HDAC6, IL2, MIR27B, ZEB2, IL17D, MIR23B, MIR22, GATA3, FASLG, GABPA, SOCS3, MMP14, IL27, TICAM2, CDH1, MIR107, CDKN2B-AS1, SERPINB4, SOX2, CCL2, ABCB1, TMED7-TICAM2, NT5E, ST6GAL1, BRIP1, DAPK1, SERPINE1, SLC2A1, SKP2, CHEK1, IL17F, NFKB1, PGR, TWIST2, MTR, PSMD9, PRL, MUC1, EIF4E, IDO1, KL, PIN1, IL4, TPX2, RAC1, MIR337, ST3GAL4, TBC1D9, MIR27A, PMEL, SLC9A3R1, MIR221, PLAU, IL12B, KLF4, STIL, PKM, RBBP4, NDUFA13, RRM2, HLA-G, MIR34B, SETD2, RPE65, MUC16, UBE2C, PYCARD, TMC6, KLRK1, KHDRBS1, PPARG, POU5F1, NOP53, STOML2, YAP1, CKAP4, HMGA1, RUBCNL, MIR211, MYBL2, MIR15A, MBL2, NCL, TMC8, MIR149, MIR148A, MIR10A, CD276, MRPL36, THBS2, MET, PDCD1, MTRR, MIR139, MGMT, MIR132, STIM1, TAP1, MIR124-2, MIR125A, TCF3, MRC1, HSP90B1, UVRAG, SMAD3, SOX1, JUN, CD82, MIR130A, SLC52A1, SLC5A5, NR1I2, LAPTM4B, LGR5, SLC9A1, KRT17, DIABLO, SLC12A9, HMGA2, PEBP1, FOSL1, MIR183, SEMA6A, SLN, MIR18A, MIR17, NSD2, TLR2, SEC14L2, AR, AMHR2, G6PD, JAG1, CDC42, UCA1, CDK1, STS, GJB1, MIR433, LINC00958, CCR5, BIRC2, GLI3, BLACAT1, MIR940, EGR1, MIR378A, CAT, ERBB3, POU5F1P4, CDK4, F3, FGFR2, FGFR4, EFEMP1, FOXC1, CISH, CHI3L1, POU5F1P3, NCK1-DT, MIR494, ESR2, FN1, FOLR1, FOS, ALB, FPR1, CDK5, AMH, ELK1, DNMT3B, CALCR, ANGPT2, BDNF, DNMT3A, KLRC4-KLRK1, ACTN4, MICA, MIR506, NOL7, CD24, ROS1, SNHG14, ROCK1, RFC4, XIAP, ANXA5, RACK1, ZEB1-AS1, SLC52A3, DLX6-AS1, RECQL4, CTHRC1, NDRG1, CYP2E1, PRLR, CYP2D6, GRAP2, ANXA1, TP53INP1, PSG2, CD55, SNHG4, TACC3, HULC, SNHG12, TSLP, SERPINB3, ATXN1, S100A9, WT1-AS, CD83, COMT, APRT, OIP5-AS1, RRAS, TDRG1, DCUN1D1, FOXQ1, MIR758, MIR454, HS3ST2, CRP, HOXA11-AS, RAB5A, GOLM1, MSLN, PSMA1, MAPK14, MIR944, WWOX, CTDSPL, MDC1, MAPK8, TRIM28, IL23A, KEAP1, MIR374B, MELK, APEX1, BAG3, CASC2, ABCG2, CRKL, QKI, RB1, KIF20A, PPP2R1B, AIM2, PTPA, ROCK2, PRKAA1, CRK, MSI2, GDF15, PSG5, PRKAA2, RALA, RAF1, TNFAIP8L1, IFNL3, BCAP31, NAT2, PTTG1, NR2C2, AXL, UBE2B, PPM1D, MYDGF, TWIST1, API5, TSG101, SOX17, TRAF6, SNHG16, AKTIP, AKIP1, CCAT1, GSDMB, TNFRSF1B, TTN-AS1, STC2, USO1, CCNB1, TLR3, SEC62, TIMP3, CA12, VPS51, CXCL5, XRCC5, TFPI2, AIMP2, DEK, IL1R2, PAX8, PRDM2, MZF1, ZIC2, PCDH10, ARID1A, XRCC2, C1QBP, XIST, WNT11, WNT10B, SLC46A2, TMPOP2, BRCA1, ZNF350, SOX21-AS1, BSG, VHL, CD34, CD36, KDM3A, TIMELESS, MIR466, SOX4, RIF1, MIR2861, TSC22D1, MIR338, IER3, PIWIL2, CEBPD, CFTR, SLC6A8, BECN1, MBD2, PEG3, HCFC1R1, SHBG, MTA1, LATS1, SFRP1, HAVCR2, SYTL2, SDC1, GGH, CDK6, NRP1, AKNA, ATF1, TGFBR2, TGFBR1, CD40, CD47, TBL1XR1, CCAT2, TCF7L2, LUCAT1, TCF4, MCM10, TNFRSF11A, TNFRSF10C, FBXW7, TET1, AURKA, STC1, PPP1R2C, CDH13, CDK2, STAT1, PGD, IER5, SERPINF1, MFAP1, MIR196A1, FLNB, COPS6, MIR199B, LCN2, STMN1, MIR200A, FLT4, DKK3, FOSB, KNG1, MIR204, MIR193B, KCNH1, IL24, JUND, JUNB, FUS, MIR146B, GREM1, AGER, WIF1, MIR491, LGALS9, BTG3, MIR187, MCM2, BLCAP, MIR205HG, MIR486-1, FANCD2, PTK2B, MDK, CD46, MIR150, MIR152, MCM4, MCL1, LMX1A, MIR484, FEN1, SMAD7, SMAD2, EPCAM, MIR505, MIR503, FOXC2, MIR499A, IL37, MIR485, ITGA6, MIR224, DICER1, HSP90AA1, POU2F3, SERPIND1, HSPA5, TNFAIP8, HIC1, HK2, TRIM29, USP22, SASH1, SIRT3, MIR30A, ACTB, HOXA11, HOXA9, MIR135B, HOXA1, ACP3, SUZ12, MIR331, MIR335, HLA-DOA, HTC2, ICAM3, CXCL10, MIR425, IL18, FBXL5, MIR25, GLI1, IL12A, DGCR5, MIR26B, MIR429, SFN, GPER1, POLDIP2, IFNA1, MIR383, MIR381, CCN1, IGFBP3, RNF19A, GSK3B, ADCYAP1, MIR29B1, MIR29B2, IFNA13, ETS1, PBXIP1, SPINT2, MIR127, ALPP, AGR2, MIR106B, MIR574, NOTCH3, DHCR24, MSI1, PRKN, MIR411, TUSC8, ALDH1A1, NQO1, ANGPT1, EIF4G2, CCEPR, MIR605, NME1, MUC4, PA2G4, OGG1, NCK1, KLF1, MIR590, KMT5A, MIR10B, MIR100, ATN1, EPHA3, MMP11, TRIM3, LINC01193, LINC00511, PGRMC1, MIR137, HAGLR, MLH1, PPP1R13L, PDPN, EPO, TIMM8A, NXF1, NTRK1, HTRA2, CYCSP38, AHSA1, UHRF1, MMP13, LETMD1, PRPF31, MBD5, SZRD1, NPTN-IT1, LNCRNA-ATB, HDAC8, RXFP3, PART1, CHTOP, CCDC106, CBX8, PANDAR, NUSAP1, DCAF6, TIPARP, IRAIN, MARCHF2, DEFB103B, DNMT3L, TLR8, PNO1, KMT2E, KCNIP1, ACKR3, ADGRE2, ASAP1, AKR1B10, SH3BP1, FAM215A, GEMIN4, PCAT1, CASP14, ATXN7L3, PLAAT1, NUP107, PAK5, SALL4, TP73-AS1, SYCP3, LINC00702, LPAR3, FALEC, NUP62, DCTN4, KIF4A, BRMS1, ING4, PRMT8, ANGPTL4, EIF5A2, MLXIPL, SLC39A6, PTCSC3, H3P9, MEPE, GHET1, ERO1A, SNHG1, EFEMP2, CSAG2, LDOC1, SMYD2, ASCC1, CCAR1, MIR6857, ZBTB7A, PCBP2-OT1, DHDH, DPP8, AHDC1, ERAP1, ST7L, CASZ1, PINX1, ATAD2, MARCHF1, ATP8A2, SALL3, RRM2B, PID1, NXT1, FKBP14, C5orf66-AS1, DDN-AS1, GPC3-AS1, ESRP1, MCTS1, CHFR, KRT20, MIR6852, RBMS3, LINP1, MIR8075, SPA17, UBE2S, WNT4, MCAT, DLL4, APTX, INO80, GALNT7, RAB39A, REM1, RGCC, TRIM44, AHI1, TRPM7, LINC01535, ARHGAP17, FANCL, RIPK4, MIR6893, SFMBT1, LARP6, RHCG, CASC9, CNNM3, PTTG3P, ZNF331, YOD1, CMPK1, BRD7, OTUD5, PRSS50, NLRP2, LOC112543491, ZNF692, URGCP, NBPF1, VPS53, TRIAP1, DTL, LAMP3, GINS2, CDCA8, RTRAF, MTPAP, AGO2, CEP55, RBMX2, MYLIP, KLF13, GOLPH3L, RAB14, BBC3, SIRT7, NCKIPSD, ATAD3A, TRIM62, FOXP1, ANKRD40CL, MIR340, NNT-AS1, BCAR4, DNLZ, MAFIP, MAPK8IP2, MIR655, MIR641, MIR638, LHFPL4, CA13, MIR630, FEZF1, CSAG3, MIR625, ST20, MIR620, C17orf97, STING1, TOB1-AS1, CASC15, RASA4CP, MIR618, MIR613, MIRLET7B, MIRLET7D, MIR106A, MIR600, MIR122, MIR573, MIR449B, MIR421, MIR124-1, STXBP5-AS1, SYS1-DBNDD2, NDRG2, SNORD111B, IDO2, ADAMTS18, PRSS55, HIPK1, MTLN, MED19, LTO1, MARCHF8, SKA3, LINC00518, MIR744, CTAG1A, VTRNA2-1, MSRB3, MIR802, MYPOP, MIR9-3HG, IS1, SBF2-AS1, H19, GATC, HNF1A-AS1, ZSCAN1, LYPD5, LINC01305, PNPLA1, FAM83H, TMSB15B, TRIM59, ZAR1, SNHG20, PAX8-AS1, LGALS7B, MIR370, BDNF-AS, MIR296, MIR299, MIR379, MIR377, MIR196B, MIR301A, MIR302A, MIR30D, MIR30E, MIR373, MIR32, MIR372, MIR320A, MIR7-3, PSG10P, MIR376C, MIR96, MIR99A, MIR99B, DEFB103A, LHX8, PSG8, ZFAS1, MIR148B, MIR324, MIR367, MIR328, MIR330, MIR346, DEFB104B, MIR449A, MIR26A1, MIR362, MIR130B, LINC00273, NORAD, MIR134, MNX1-AS1, LINC02604, MIR141, LINC01128, CERNA2, MIR502, MIR181A2, MIR186, MIR192, MIR522, MIR519D, MIR197, MIR498, MIR200C, MIR432, MIR492, MIR210, MIR202, MIR212, MIR215, MIR217, MIR218-2, MIR223, MIR409, MIR20B, MIR877, DDX53, FEZF1-AS1, LRRC8E, CENPM, FTO, OCLN, BRCC3, FSD1, DSCAM-AS1, HMBOX1, NDNF, RHBDF2, RABEP2, ZNF671, GAS5-AS1, NANOG, GRHL2, ASRGL1, ALL2, LINC01133, MIR3666, RNF34, MIR3941, ITPKC, MIR374C, ZKSCAN3, COASY, ITIH5, LINC00673, YIPF5, MIR4262, SPRY4, ST6GALNAC5, RHPN1-AS1, PCAT6, USP46, CASP12, REXO1, GATAD2B, HECW2, MIB1, SPRY4-IT1, MIR4429, ARRDC3, MIR4778, MRTFA, MIR4784, MIR4636, NCOA5, NS2, JAM2, AFAP1, APOBEC3G, HPSE2, CELF6, PRDM14, PCGEM1, LHPP, SEMA4A, ROBO3, RHBDF1, ZMAT3, DLG1-AS1, ARAP3, GIHCG, MARCHF7, SHARPIN, CCDC3, MIR665, ZG16B, TPT1-AS1, TRAP, PRRT2, CYTOR, CMTM7, CALML3-AS1, NACC1, TNRC6C-AS1, TMEM54, ANIB1, LRG1, TMPO-AS1, MIR889, TMEM132D, CYB5D2, SESN2, OSCP1, CMPK2, MIR874, ZFP42, PIP5KL1, FUNDC1, DEFB104A, PIWIL4, OR2AG1, LINC00052, ILF3-DT, ZNF582, MIR216B, AMOTL1, FOXP2, WDR20, CCDC34, IL33, CALN1, JAM3, LONP2, FSD1L, MAGT1, MIR1202, MINDY4, MIR664A, MIR1266, RPAIN, MIR1297, ELOF1, MIR1246, MAK16, MIR1284, DEFB4B, SPZ1, CCDC54, AFAP1-AS1, LINC00467, FOXD2-AS1, ADO, TMEM238L, ATAD1, RITA1, AJUBA, SNHG7, CASC11, KLC4, EMC6, GEMIN2, ZNF281, IRF6, INPP5A, IL16, IL13, CXCR2, IL7R, IL6R, IL4R, IL1RAP, IL1R1, IGF2R, IFNB1, IFNA17, ID4, ID1, ICAM1, IAPP, HSPB2, IRF3, ITGA2B, LIF, ITGA4, LEP, LDHA, LAMB3, L1CAM, KRT14, KRT13, KPNB1, KLK1, KISS1, KCNK3, KCNA1, JAK3, ITPR3, STT3A, ITGAV, ITGAE, ITGA5, HSPB1, HSF1, AGFG1, HPGD, HLA-E, HLA-DQB2, MNX1, HLA-C, HGFAC, HDAC2, HCFC1, GTF2H1, GSTM3, GSTM2, GSN, PDIA3, CXCL3, NR3C1, GRB7, GPX3, GPX2, HMGB2, HMGB3, HMMR, HOXB7, HP, HOXD9, HOXD@, HOXC10, HOXC8, HOXC6, HOXB8, HOXB2, HMOX1, HOXA13, HOXA5, HNRNPA2B1, HNRNPA1, FOXA2, FOXA1, NR4A1, LGALS7, LIG1, MAPK6, PECAM1, PC, PBX3, PAX3, PAX2, REG3A, P2RX7, OCA2, YBX1, NPTX1, NPM1, NPAT, CCN3, NOS3, NOS1, NNMT, NKX6-1, NFX1, PDK1, PLA2G4A, LIPA, PLG, PRKCB, PRKCA, PRKAB1, PPP3CA, PPP1R1A, PPIA, PPBP, PPARA, POU5F1B, POU3F3, POU2F1, POLR2E, PML, PLXNB1, PLSCR1, PLOD2, PLK1, TONSL, NFKBIA, NFATC1, NEUROD1, MEST, MEN1, MAP3K5, MAP3K3, MEF2D, MECP2, MDM4, MCM7, MCM5, MBNL1, MAP2, LYN, LTBP3, CYP4F3, LOXL2, LOX, LNPEP, MELTF, SCGB2A2, KITLG, MSX2, NELL1, NDUFS6, NDUFB8, NBN, MYOD1, MYL5, MMUT, MSX1, MICB, MST1, MSH2, MYO1B, MPG, MMP15, MAP3K11, MKI67, GPC1, GOT1, GNAO1, CDK9, CDC25C, CDC25A, CDC20, CDC6, ADGRE5, CD68, CD53, ENTPD1, CD38, CD80, CCND3, CCNA2, CBR1, RUNX2, CAV1, CASP7, CA11, CDK7, CDKN2B, GNA12, CDX1, CREM, CPOX, CPE, COX8A, SLC31A1, KLF6, CCR6, CMA1, CLU, CKS2, CKB, CHRNA4, RCC1, CEACAM7, CEACAM3, CEBPA, CEACAM5, BRCA2, FOXL2, BNIP3, BMP7, APOB, BIRC3, APEH, APC, ANXA6, ANXA2, ANG, ALPI, ALK, AKT2, AIF1, NR0B1, ADM, ADAR, ADAM10, ACVR1, ABL1, AQP8, AQP1, ARF1, BAX, PRDM1, BHMT, BDKRB2, BCYRN1, BCL2L2, BCL2A1, BCHE, BAG1, RHOB, BAAT, ATR, ATP7A, ATIC, ASTN1, PHOX2A, ARHGAP1, CRH, CRIP1, CRYZ, EPAS1, FHL2, FBP1, FANCF, FANCC, FANCA, FABP5, FABP4, ESRRA, ERCC5, ERCC4, ERCC2, ERBB4, NR2F6, EPS8, EPHX1, EPHB6, EPHB4, FOXG1, FOXF2, FOXD1, XRCC6, GLI2, GLB1, GPC3, GFI1, GCNT2, KAT2A, GAPDH, FTH1P3, FOXO3, FSHR, FRZB, FRK, FRA11A, FLT3LG, FLT1, FLG, STOM, ENG, CSF1, ELF1, BRINP1, DAP, CYP19A1, CYP1B1, CYBB, CYBA, CTSS, CTSL, CTSG, CTSB, CCN2, CTAG1B, CSRP1, CSNK2A1, CSN2, CSF2, CSF1R, DCK, DCN, ACE, DUSP3, EIF4A1, EGR2, EFNA2, ECM1, TYMP, E2F3, DVL1, HBEGF, AKR1C1, DPH1, DLX1, DEFB4A, DHX9, DDX5, DDT, GADD45A, PRKCD, MAPK10, SRRM2, CD163, SOCS6, STK17A, PDLIM7, UBE2L6, MTA2, AURKB, LPAR2, SCAF11, EXO1, ATG12, AIFM1, USP8, CLDN1, SPAG9, SEMA5A, LIMD1, HSPB3, TRIP4, SLC9A3R2, FRAT1, SLIT2, ZBTB33, SCO2, SLC12A6, MFN2, RBM19, RASSF2, KMT2B, DCAF1, NUP93, KDM4A, PPIP5K1, ISG15, GOSR1, TBPL1, MAP4K4, COX5A, PLAA, RPS6KA4, P4HA2, MBD4, BCL10, RIPK1, URI1, NOL4, ABCC3, B4GALT3, SRSF9, EIF3F, NUMB, AKR1C3, EIF4EBP3, RUVBL1, PDLIM4, IFITM1, PIK3R3, ABCA4, RECK, UTF1, TNFSF14, TNFSF9, ADAM9, CFLAR, SQSTM1, SPHK1, ARHGEF7, ASAP2, AKAP4, PROM1, CCN4, NRP2, RAB11A, INPP4B, BANF1, IL18R1, TRIM24, TNFRSF10D, SNAP23, TNFRSF6B, BCL2L11, PARP2, MAP2K3, MGLL, PDAP1, ZHX1, RASSF8, KLK8, FGFR1OP, PRDM5, TENT4A, TMSB15A, METAP2, CCNI, PRSS21, PRDX3, SUB1, PAPOLA, LYVE1, MRPS30, HCP5, TUSC2, DNAJC8, ABCF2, CPEB3, CBX7, BRD4, ICMT, SF3B1, PUM2, FBXW11, RRS1, ARL6IP1, SMC5, WAPL, CEP131, KDM2A, NT5C2, KIN, SIRT2, CARD8, MLXIP, SEPTIN9, ZNF268, SRSF10, PLK2, GPNMB, CFDP1, PRMT5, BASP1, NDC80, SYCP2, TUBA1B, B3GNT3, DLEU1, PAK4, LILRB2, ABCC4, SPRY2, SPRY1, RBM5, WASF2, EBI3, CLEC10A, HOXB13, ENOX2, POSTN, NES, PLAC1, GIPC1, MASP2, POLD3, CTCF, IGF2BP1, TXNIP, SEMA4D, MRPL28, LAMTOR5, RNASEH2A, ATG7, NEBL, KAT5, SEMA3C, NR0B2, TAGLN2, SPARCL1, CCL22, CCL16, SCN8A, SCN1A, SATB1, S100B, S100A11, S100A7, S100A4, S100A1, RPS19, RPS12, RPS6KB1, RNASEL, RNASE4, RNASE3, REV3L, REN, CCL19, CXCL6, SOX14, SDHA, SMN2, SMN1, SMARCA4, HLTF, SNAI2, SLC16A1, SLC10A2, SLC6A6, SLC1A5, SIM1, ST3GAL3, SGK1, SRSF1, SFRP4, SFRP2, MAP2K4, SEL1L, REL, RECQL, RBP1, RBL1, PTK2, PTGS1, PTGER3, PTCH1, PTBP1, PSMD4, PSMD2, PSMB10, PSMB9, PSMB8, PSMB4, PSMA7, PSEN1, KLK10, MASP1, LGMN, MAP2K7, PTK6, PTK7, PTN, MOK, RBBP6, RASGRF1, RASA1, PLAAT4, RAP2B, RAP1A, RAD52, RAD51B, PTPN6, RAD21, PXN, PTX3, PTPN14, PTPN13, PTPN11, PTPN9, SMS, SNAI1, SNCB, TTR, YWHAZ, XRCC4, XPO1, XPNPEP2, WNT2B, WNT7A, WNT6, WEE1, VDR, VDAC1, VCP, NR1H2, UGCG, UCP2, UBE2E2, UBB, TYMS, ZNF84, MALL, SCLC1, NRIP1, FZD7, FZD4, CDC7, BAP1, AXIN1, TKTL1, SMC1A, NCOA3, USP7, MIA, TCL1A, KMT2D, MFAP5, PSCA, SEM1, SLC39A7, TUFT1, TRIO, SNCG, TRAF3, HNF1A, TBP, TAT, TAPBP, MAP3K7, SYK, SUV39H1, STAT6, STAT5B, STAT5A, STAT2, SSRP1, SRF, SPARC, SOX11, SOAT1, FSCN1, TCF7, TRBV20OR9-2, TDO2, KLF10, CRISP2, TOP1, TNFAIP2, TM7SF2, TKT, TIMP1, TIAM1, THOP1, TEK, THBS4, THBS1, THBD, TGFA, TFRC, TFF3, TERF2, H3P40
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Brachydactyly, Type E1
Omim
Hertzog (1968) suggested that there are at least 3 subtypes of BDE: E1, in which shortening is limited to fourth metacarpals and/or metatarsals (Hortling et al., 1960); E2, in which variable combinations of metacarpals are involved, with shortening also of the first and third distal and the second and fifth middle phalanges (McKusick and Milch, 1964); and E3, a dubious category which may have a variable combination of short metacarpals without phalangeal involvement.
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Tuberculosis
Wikipedia
Tuberculosis may infect any part of the body, but most commonly occurs in the lungs (known as pulmonary tuberculosis). [9] Extrapulmonary TB occurs when tuberculosis develops outside of the lungs, although extrapulmonary TB may coexist with pulmonary TB. [9] General signs and symptoms include fever, chills , night sweats, loss of appetite , weight loss, and fatigue . [9] Significant nail clubbing may also occur. [17] Pulmonary If a tuberculosis infection does become active, it most commonly involves the lungs (in about 90% of cases). [15] [18] Symptoms may include chest pain and a prolonged cough producing sputum. ... However, the difficult culture process for this slow-growing organism can take two to six weeks for blood or sputum culture. [73] Thus, treatment is often begun before cultures are confirmed. [74] Nucleic acid amplification tests and adenosine deaminase testing may allow rapid diagnosis of TB. [68] These tests, however, are not routinely recommended, as they rarely alter how a person is treated. [74] Blood tests to detect antibodies are not specific or sensitive , so they are not recommended. [75] Latent tuberculosis Main article: Latent tuberculosis Mantoux tuberculin skin test The Mantoux tuberculin skin test is often used to screen people at high risk for TB. [69] Those who have been previously immunized with the Bacille Calmette-Guerin vaccine may have a false-positive test result. [76] The test may be falsely negative in those with sarcoidosis , Hodgkin's lymphoma , malnutrition , and most notably, active tuberculosis. [14] Interferon gamma release assays, on a blood sample, are recommended in those who are positive to the Mantoux test. [74] These are not affected by immunization or most environmental mycobacteria , so they generate fewer false-positive results. [77] However, they are affected by M. szulgai , M. marinum , and M. kansasii . [78] IGRAs may increase sensitivity when used in addition to the skin test, but may be less sensitive than the skin test when used alone. [79] The US Preventive Services Task Force (USPSTF) has recommended screening people who are at high risk for latent tuberculosis with either tuberculin skin tests or interferon-gamma release assays. [80] While some have recommend testing health care workers, evidence of benefit for this is poor as of 2019 [update] . [81] The Centers for Disease Control and Prevention (CDC) stopped recommending yearly testing of health care workers without known exposure in 2019. [82] Prevention Tuberculosis prevention poster from the United States, c. 1940 Tuberculosis prevention and control efforts rely primarily on the vaccination of infants and the detection and appropriate treatment of active cases. [15] The World Health Organization (WHO) has achieved some success with improved treatment regimens, and a small decrease in case numbers. [15] Vaccines Main articles: Tuberculosis vaccines and BCG vaccine The only available vaccine as of 2011 [update] is Bacillus Calmette-Guérin (BCG). [83] In children it decreases the risk of getting the infection by 20% and the risk of infection turning into active disease by nearly 60%. [84] It is the most widely used vaccine worldwide, with more than 90% of all children being vaccinated. [15] The immunity it induces decreases after about ten years. [15] As tuberculosis is uncommon in most of Canada, Western Europe, and the United States, BCG is administered to only those people at high risk. [85] [86] [87] Part of the reasoning against the use of the vaccine is that it makes the tuberculin skin test falsely positive, reducing the test's usefulness as a screening tool. [87] Several vaccines are being developed. [15] Intradermal MVA85A Vaccine in addition to BCG injection is not effective in preventing tuberculosis. [88] Public health The World Health Organization (WHO) declared TB a "global health emergency" in 1993, [15] and in 2006, the Stop TB Partnership developed a Global Plan to Stop Tuberculosis that aimed to save 14 million lives between its launch and 2015. [89] A number of targets they set were not achieved by 2015, mostly due to the increase in HIV-associated tuberculosis and the emergence of multiple drug-resistant tuberculosis. [15] A tuberculosis classification system developed by the American Thoracic Society is used primarily in public health programs. [90] The benefits and risks of giving anti-tubercular drugs in those exposed to MDR-TB is unclear. [91] Treatment Main article: Tuberculosis management Treatment of TB uses antibiotics to kill the bacteria. Effective TB treatment is difficult, due to the unusual structure and chemical composition of the mycobacterial cell wall, which hinders the entry of drugs and makes many antibiotics ineffective. [92] Active TB is best treated with combinations of several antibiotics to reduce the risk of the bacteria developing antibiotic resistance . [15] The routine use of rifabutin instead of rifampicin in HIV-positive people with tuberculosis is of unclear benefit as of 2007 [update] . [93] Latent Latent TB is treated with either isoniazid or rifampin alone, or a combination of isoniazid with either rifampicin or rifapentine. [94] [95] [96] The treatment takes three to nine months depending on the medications used. [44] [94] [97] [96] People with latent infections are treated to prevent them from progressing to active TB disease later in life. [98] Education or counselling may improve the latent tuberculosis treatment completion rates. [99] New onset The recommended treatment of new-onset pulmonary tuberculosis, as of 2010 [update] , is six months of a combination of antibiotics containing rifampicin, isoniazid, pyrazinamide , and ethambutol for the first two months, and only rifampicin and isoniazid for the last four months. [15] Where resistance to isoniazid is high, ethambutol may be added for the last four months as an alternative. [15] Treatment with anti-TB drugs for at least 6 months results in higher success rates when compared with treatment less than 6 months; even though the difference is small. ... Inadequate healthcare also means that people with active disease who facilitate spread are not diagnosed and treated promptly; sick people thus remain in the infectious state and (continue to) spread the infection. [46] Geographical epidemiology The distribution of tuberculosis is not uniform across the globe; about 80% of the population in many African, Caribbean, south Asian, and eastern European countries test positive in tuberculin tests, while only 5–10% of the U.S. population test positive. [14] Tuberculosis is more common in developing countries; about 80% of the population in many Asian and African countries test positive in tuberculin tests, while only 5–10% of the US population test positive. [14] Hopes of totally controlling the disease have been dramatically dampened because of a number of factors, including the difficulty of developing an effective vaccine, the expensive and time-consuming diagnostic process, the necessity of many months of treatment, the increase in HIV-associated tuberculosis, and the emergence of drug-resistant cases in the 1980s. [15] In developed countries, tuberculosis is less common and is found mainly in urban areas. ... The Latin root "con" meaning "completely" is linked to "sumere" meaning "to take up from under." [178] In The Life and Death of Mr Badman by John Bunyan , the author calls consumption "the captain of all these men of death." [179] "Great white plague" has also been used. [176] Art and literature Painting The Sick Child by Edvard Munch , 1885–86, depicts the illness of his sister Sophie, who died of tuberculosis when Edvard was 14; his mother too died of the disease.SLC11A1, TIRAP, HP, CORO1A, ASAP1, RGS12, MFN2, SLC14A2, HLA-DRB3, CD14, CCL5, CCL2, NAT2, CFP, P4HB, STAT3, NOS2, MT1JP, P2RX7, TLR2, TGFB1, TLR1, MMP1, TLR4, CAT, TNF, ELF3, TSC1, TSC2, VDR, CAMP, CCN6, MMP9, LSAMP, MBL2, ARTN, CYP2E1, CYP2B6, HLA-DQB1, HLA-DRB1, HLA-DRB5, HPD, HSPD1, SP110, CRP, IFNA1, IFNA13, IFNG, IFNGR1, IL1A, IL1B, IL2, IL2RB, IL4, IL6, CXCL8, IL10, IL12B, IL12RB1, IL17A, IL18, INHA, CXCL10, SOCS3, TOP2A, ESAT, RHOF, LINC02618, TGM6, CD209, IL22, MBL3P, FOXP3, ADA, TLR9, NCAPG2, LAMP3, ZNF630, IRGM, NOD2, DYNC2H1, RNF34, ESX1, RBM45, AGRP, AGO2, VSX1, BCAR1, SLC14A2-AS1, LINC02211, NEBL, C2CD2, SMUG1, MAPK1, IL23A, INTS4, CSF2, NR1I2, GNLY, FCGR1A, WNT3, TRBV20OR9-2, CDR3, GC, TST, CISH, CTNND1, NTM, HSPA4, IL1RN, CD274, NLRP3, CSE1L, TMX2-CTNND1, IL15, FCGR3A, PTBP2, MAPK14, IL27, CD1B, CHP1, CD27, MAS1, MIF, GSTM1, SPP1, CLEC4E, TPPP, MIR29A, PTBP1, HPGDS, HLA-A, GEM, GSTK1, HIF1A, THEMIS, HSPE1, IL32, CACNA1G-AS1, POLDIP2, GRAP2, MARCO, EBI3, AIMP2, TLR6, AHSA1, MASP2, TMED2, RNF19A, IL37, NRSN1, PDCD1, MT1E, IL17D, KIR3DL1, CD163, IL13, HAMP, IL17F, SLCO6A1, IRF1, H3P19, CRK, CD9, CCR5, ALB, AKT1, BRCA1, SIRT1, CPAT1, GZMB, BMS1, ISG15, ABCG2, IFNB1, PTGS2, SFTPA2, CXCR3, FCGR3B, ABCB1, ARG1, SAT1, SFTPA1, IL2RA, SOCS1, CYP3A4, MYDGF, SFTPD, ACTB, IL18R1, HSPA14, MIR155, HMOX1, HLA-C, NDUFAB1, MYD88, MRC1, ACACA, HLA-DQA1, IL9, SDHD, NFKB1, ITGAX, IL5, SLCO1B1, ISG20, AHR, IL21, TYMS, DHFR, CDX2, BATF2, IL7, DEFB4A, MC3R, DEFB1, GAPDH, CGAS, MTOR, PPARG, TLR8, RPSA, CMPK1, CD44, MCL1, PIK3CG, HSPG2, TOLLIP, BCL2, HLA-B, PTPN22, TAP1, LAMP1, CCR6, CCR4, MIR144, HLCS, TNFRSF1A, IFNAR1, CCL4L1, TICAM2, TAP2, CORD1, KRIT1, STING1, ICAM3, CR1, TXN, SMS, TNFRSF1B, BTNL2, CD36, IL23R, LTA4H, PIK3CD, LTB, PIK3CB, PIK3CA, SH2D1A, LYZ, PC, SMARCAD1, MFAP1, NTRK1, CXCL9, CD48, CD40, CMPK2, COX2, CD40LG, LPA, TLR10, POMC, LCN2, IL7R, CXCR2, CCL4, CCL3, SRL, S100A6, INSRR, ALOX5, TXNRD1, COPD, CLEC7A, KIR2DS1, MAPK8, CAMKMT, LAG3, PDCD1LG2, LAMC2, HLA-E, MT1A, LARS1, CALM2, GPT, KLRC4-KLRK1, SIT1, FASN, KLRG1, ACAD8, MIR20B, CYP2C9, EGFR, GATA3, ABCB6, PRDX5, SQSTM1, TST1, LINC01672, FPR1, SEC14L2, ARHGEF2, EPHB2, CARD8, FOXO3, KLRK1, CCL4L2, CTSZ, DEFB4B, POTEF, CCR2, F3, TBC1D9, CALM1, ST11, MTCO2P12, CYBB, DEFB103A, IRAK4, LINC02605, SARDH, GSTT1, VIM, DECR1, VEGFA, DHX9, APRT, CALM3, TLR7, TYS, SETX, MUC1, PARP9, PLG, INO80B, HCST, SPATA2, DBA2, PRKCD, IL27RA, NCR1, CEP290, ATP6AP1, AIM2, CXCL13, PPID, LILRB1, PLA2G2A, IL33, PHB2, PGM1, SLC9A6, HAVCR2, KLF2, EBPL, LANCL1, RABEPK, NXF1, PDE6B, PDR, SLC27A5, NPPA, SDS, HDAC6, NOTCH4, EBNA1BP2, WASF2, SERPINA1, ZNRD2, OPTN, PPIF, MUC16, ATP2A2, NCAM1, PKP3, PRL, LARS2, PSMB8, SLC34A1, SMPD1, DEFB103B, FASLG, SNCA, SPN, STAT1, EPX, MAFK, TAT, ATG16L1, SARS2, TRIT1, UGT1A1, TGFBR2, THBD, TIMP1, HSD17B8, SCG2, ZYX, SOST, CASR, TMED7, RTEL1, CD244, TRC-GCA24-1, CASP8, CASP3, ANXA5, UGT2B7, TBX21, USO1, PSMD7, TP63, PSMD9, CD86, DST, PMPCA, TBC1D1, SIGIRR, RAB33A, RORC, RPL17, MLYCD, ZNF410, ALOX15, BRCA2, SARS1, CCL1, CD28, FCGR2C, CCL3L1, ATD, KIDINS220, CCL20, CCL22, WASF1, SELL, SFRP1, ASL, SOCS2, ART1, SLC17A5, PLA2G10, DCTN6, MIRLET7B, FCGR2A, CEBPA, IDO1, GAST, FTH1, IRF7, FN1, ADRA1D, FLNB, FOXO1, MIR582, FCN2, CYP3A5, CYP7A1, TNFRSF9, PTK2B, KIR2DL1, AFA1, CDA, KIR3DL2, CYP27B1, ERF, EREG, TMED7-TICAM2, MICA, KLRC2, LBP, CEBPB, CEL, CLYBL, IFNA2, MIR223, GZMA, MIR146A, CYP2C19, MIR140, CTLA4, NR3C1, MALAT1, IRF8, PLF, ASPG, IFI27, CREB1, IL12RB2, GLUL, IFNGR2, GLI3, ARMH1, ANO9, CLEC4D, MT1DP, LIN9, CXCR1, ARAFP2, CHIT1, CHGB, LBR, HIP1, MMP2, DTYMK, ACR, RPL17-C18orf32, LRRK2, TST2, AGER, ELANE, EMB, CD68, AGTR2, GBP5, MEN1, MMP7, H3P23, MDP1, MBP, CYP51A1, BTLA, LEP, LGALS3, NQO1, ABCA4, MIP, MPO, LGALS9, DSPP, MMP3, ACE, ELK3, H3P28, SMR3B, TBK1, SETD2, IGHV3-75, SGSM3, TOR1B, MIR381, ARNT, FASTK, MIR423, C5AR2, GSTT1-AS1, IL17B, ARSA, MIR424, DEFB104B, ERVK-19, B3GAT1, FOXP1, ARSB, H4C15, ATP2C1, RNU6-6P, ARAF, LY75-CD302, ICOS, ATP4A, MIR30B, MIR30C1, DCTN4, MIR30C2, MIR31, NRG3, MIR32, APC, APCS, MIR33A, TRAT1, APEH, MIR93, MIR96, HPSE, HILPDA, POTEKP, GEMIN4, FAS, IL21R, IL20, MIR337, NOX4, MIR376C, DUOX2, KLK12, MIR196B, HAVCR1, SLC40A1, ERVK-32, AQP4, ILVBL, HNP1, PCED1B-AS1, BRD4, ERVK-11, ATP12A, MIR579, DICER1, KIF3A, ERVK-9, SYNM, ATM, MORN2, METAP1, SIGLEC14, KIR2DS2, PTP4A3, TIMM23, SNORD104, SMG1, SPEN, H3C9P, NT5C2, SIRT2, FSTL1, WDHD1, MIR1178, IRAK3, CILK1, ACOT7, KLHL2, ATF3, DCTN3, CABIN1, DUSP14, VPS33B, NOCT, STS, PHGDH, MIR486-1, PRPF31, POTEM, LOC102724971, AKAP13, TMEM72, MOXD1, CHMP2B, SMIM10L2B, SERPINC1, PART1, MT1XP1, LOC102723407, NT5C3A, IL17RA, ACP1, MYMX, SCAT1, LY96, IL24, TMSB15A, NUP62, SPAG11A, AMACR, KLHDC2, DDX58, RIPK3, PADI4, RBFOX2, AHCY, MIR27A, CCNY, NLRP11, VKORC1, FTO, ZXDC, PAGR1, SLC52A2, AKR1B1, CRYGEP, VTCN1, SUGCT, NLRC3, AGBL2, HDAC11, STN1, ASRGL1, ALDH2, MLKL, COLEC11, MARCKSL1, MIR23A, TBATA, UBL5, RICTOR, ERVK-6, RBKS, LRRC4, SLC39A8, ALOX12, CARD9, SEMA4A, ROBO3, SIL1, ATG3, ADRB2, MARCHF7, CDK15, RNASEH1, VPS33A, ACSBG2, CLEC4C, PYHIN1, SESN2, SCAR3, TRIM4, NLRP12, ALAD, MTG1, NAF1, CLEC6A, FOXP2, DRAM2, SFXN1, OPN4, TGS1, H4-16, PRRT2, CYP2R1, MRGPRF, SLC2A13, ATG4C, ATAD1, CBR4, AGA, C1orf52, LYPD4, PWAR1, ATG10, FGFBP2, HSPE1P1, TNFSF13B, DEFB104A, TRIM63, MAGT1, CHCHD6, CARD11, UPRT, ZNF469, PACRG, RNASE7, H2BC1, NLRC4, CTDSP1, HCN1, SMIM10L2A, ANXA1, RTL1, MOV10L1, KMT5A, ACTG1, AMBP, IL31, MARCHF5, TMED9, AHI1, ALPP, RHBDL2, OXSM, ACTG2, DARS2, VPS13D, MIR155HG, MIR125A, DUOX1, MIR150, KLRF1, MAGEC2, NCKIPSD, MIR21, MIR199B, MIR18A, MIR17, SIRT6, ADAM22, MIR148A, CYRIB, MIR142, GDE1, MIR141, MIR132, ANXA2, TENT5A, RAB20, SCASI, PRPF40A, MCCC1, PLAAT1, TMSB15B, SMURF1, ALPI, NLN, MIF-AS1, CHAMP1, ARID1B, SEMA6A, TRMT5, CLEC9A, OR10A4, SPG16, IFNL3, BMP6P1, SEC14L3, MAP3K7CL, RETN, IRGC, GABRQ, INTS13, IFT122, CCL15-CCL14, IL26, EMC3, PBK, ACTBL2, ADH4, CTNNBL1, COL6A4P1, ADK, CMAS, NKRF, CFC1, ZBTB8OS, HSR, ADGRV1, CD55, KHDRBS1, CNR2, KLRB1, LAMB3, LCN1, LDHC, LIPE, LNPEP, LRP1, CD79A, LTA, CYP4F3, CD180, LY75, MARS1, CD69, MATN3, ADAM11, MEFV, MICB, CD53, MMP8, CD47, MMP10, MMP13, KLK1, KIR2DL3, KIR2DL2, CES1, CCR7, IL3RA, IL4R, IL5RA, CCR1, IL6R, TPP1, CHRM3, IL10RA, IL12A, IMPDH2, KCNMA1, CDKN1B, IRAK1, CDK9, IRF3, IRF5, IRF6, ITGA1, ITPA, JAK2, CD82, MMP14, MNAT1, MOG, PLAUR, PCNA, CDK16, PDE8A, PENK, TNFSF8, PFKM, SLC25A3, SERPINB6, SERPINB9, PIP, PMP22, PRKN, PNN, PPBP, PPIA, PPM1A, PPP1R1A, PPP2CA, PRF1, PRKAA1, PRKAA2, PRKAB1, PAWR, SERPINE1, MPG, NEDD4, ABCC1, MS, MSR1, MSX2, MUC2, MUC5AC, MMUT, NCF2, NDUFS3, NDUFS4, NFE2L2, CD38, NFKBIA, NFKBIL1, NHS, PNP, SLC11A2, NT5E, OAS1, OAS3, OPRM1, ENTPD1, IL1R1, IGHG3, PRKCA, IGHE, ESR1, EXTL3, F2, F2R, FANCC, FANCD2, FAT1, FBN2, FCGR2B, FDXR, FGFR3, FHIT, FMO2, FPGS, FUT2, GAB1, GALE, GALNS, GCNT2, MSTN, GFAP, CBLIF, GK, ESD, DMTN, ENPEP, DPAGT1, DARS1, DBP, DES, CFD, SEPTIN1, DLD, DMD, DMRT1, DYNC1H1, DNMT3B, DPP4, ENO2, DUSP3, DUSP5, DUT, EDN1, EDNRB, EEF1A1, EHHADH, MARK2, EMP2, ENO1, GLA, GLI2, GLO1, CRYZ, CTSG, CTNNB1, HPRT1, HPX, HRC, HRES1, HSPA1L, HSPA5, HSP90AA1, CTAA1, TNC, MR1, IAPP, IARS1, ICAM1, ICAM4, IFI16, CRYGC, IFNA17, IFNAR2, CPOX, IGHA1, HNRNPA1, CTSK, GLS, GTF2H1, GNA12, GOT1, UTS2R, GRB2, GRIK1, GRIK3, CXCL2, GSR, GSTP1, GSTZ1, GUSB, CTSW, HDAC1, CFH, HGF, NRG1, CYP1A1, HLA-DPA1, HLA-DPB1, CYBA, HLA-DQB2, HLA-DRA, PRKACG, PRKCB, TRIM16, ARHGEF5, BECN1, C5AR1, MBTPS1, URI1, RIPK1, TNFSF13, ADAM9, RIPK2, TNFRSF18, SUCLA2, NRP2, NRP1, GMPS, CFLAR, C3, KAT2B, CDK5R1, ALDH1A2, TSPO, TIMELESS, MBD2, SELENBP1, MAP3K14, ABCB11, OASL, HSD17B6, H4C8, CSRP3, SLC7A5, KDM5D, H4C9, H4C1, H4C4, H4C6, H4C12, H4C11, H4C3, H4C2, TNFSF11, H4C5, H4C13, H4C14, DAP, SRPX, ULK1, CAVIN2, NSMAF, FCN3, SCARF1, KLF5, BST1, USP6, SPAG11B, BCL2L10, BCL2L11, CHAF1A, IL18BP, TSPAN32, BCL2A1, LILRB2, CTPP, CLEC4M, TRIM22, IFITM3, MVP, CAP1, MYBBP1A, CIB1, BACH1, BATF, ANP32B, PROCR, BAAT, SORBS1, RBCK1, FGFBP1, MAFB, NMI, TMPRSS11D, LPAR2, HACD1, XPR1, NOG, S1PR2, CD83, KLF4, PPIG, SLC9A3R1, ADIPOQ, TJP2, BCS1L, FHL5, ADAMTS4, ADAMTS3, CXCR5, RGS6, ZNF592, SOCS5, GAB2, TLK1, SMG7, NR4A3, LAP, TNFRSF8, BAG6, RPE65, RPS4X, RPS7, RPS12, SALL1, CD19, CCL8, CCL15, CCL19, CXCL11, XCL1, SDC1, SEC14L1, SETMAR, SRSF1, SRSF3, SLAMF1, SLC2A1, SLC2A3, SLC6A3, SLC10A1, SLC22A4, SLC22A5, RPGR, RORA, BRD2, PTPRB, PROC, MASP1, HTRA1, PRTN3, PSEN1, PSMB9, PSME1, PTGER2, PTPN6, PTPRA, PTPRC, CD80, RAB27A, MOK, RAF1, PLAAT4, RASA1, RBP4, PRPH2, REL, RELA, RENBP, SLN, SMPD2, SIGLEC1, UMOD, TPI1, NR2C2, HSP90B1, TRAF6, CASP4, TUB, TWIST1, TYK2, UBE3A, UGT1A, UMPS, CASP9, UPP1, VDAC1, CASP1, CALR, WNT5A, RNF112, ZNF208, IL1R2, CXCR4, ALDH5A1, TP53, TNNI3, SNRNP70, PRDX2, CD8A, SPTAN1, CD3E, STAT4, SYK, MAP3K7, TBCA, HNF1B, TCOF1, CD1C, SERPINA3, RUNX1, TERC, TERT, TF, TFPI, TGFA, CD1A, TGFBR1, THBS4, TIMP2, CCNT1, TEK
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Chordoma
Wikipedia
Genes Chromosomes Cancer . 41 (1): 80–5. doi : 10.1002/gcc.20052 . PMID 15236319 . ^ a b Han S, Polizzano C, Nielsen GP, Hornicek FJ, Rosenberg AE, Ramesh V (March 2009). ... PMID 16757128 . ^ Delaney TF, Liebsch NJ, Pedlow FX, Adams J, Dean S, Yeap BY, McManus P, Rosenberg AE, Nielsen GP, Harmon DC, Spiro IJ, Raskin KA, Suit HD, Yoon SS, Hornicek FJ (2009). ... "Imatinib mesylate in chordoma" (PDF) . Cancer . 101 (9): 2086–97. doi : 10.1002/cncr.20618 . hdl : 2434/642716 . ... The Journal of Bone and Joint Surgery. American Volume . 87 (10): 2211–6. doi : 10.2106/JBJS.D.02693 . ... "Familial Chordoma Study of the T Gene" . Hum Genet . 133 (10): 1289–97. doi : 10.1007/s00439-014-1463-z .TBXT, TSC2, TSC1, IFNG, TBX1, MN1, EGFR, SMARCB1, MET, CDKN2A, PIK3CG, CD274, PTEN, PIK3CD, PIK3CA, PIK3CB, AKT1, PDGFRB, MTOR, BRAF, MIR140, PARP1, FSD1, MIR155, FSD1L, MIR222, KDR, TNFRSF1B, TNF, TGFB1, TP53, TGFA, TCF3, STATH, PLAU, PTPA, STAT3, SRY, SOX9, KHSRP, MAPK1, SNAI2, CXCL12, RDX, SOX2, ADA, DLK1, CD276, CD24, MIR608, MIR574, MIR455, MIR34A, MIR31, MIR193A, MIR148A, MIR125A, MIR10A, RNF144B, HAVCR2, TRIM11, MEG3, TNFRSF10B, ARID4B, GDE1, SALL3, SIGLEC7, TBC1D9, CHEK2, PSIP1, PTP4A3, SMR3B, FRS2, PDPN, TRIP13, FUBP1, KHDRBS1, PDGFRA, ABCB1, DVL1, GFAP, FLT1, FHIT, FGFR1, FGF2, FCGR3B, FCGR3A, EZH2, ETS2, ETFA, ESR1, EPHB2, EIF4E, CUX1, PGR, CTSK, CSPG4, COL11A2, LYST, CDK4, CD38, CBR1, CASP9, BRCA2, BCL6, AR, ALCAM, ACAN, GLI1, GSK3B, HCLS1, HIF1A, NTRK1, YBX1, NGF, NBN, MYC, MUC1, MTNR1B, MSH3, ABCC1, MMP1, MKI67, MGMT, MDM4, SMAD3, LIF, LGALS9, KRT19, KRT8, KRAS, KIT, INSM1, IL2RB, IGF1, IDH1, HPGD, HOXA10, SLC29A2, MIR1237