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- Yao Syndrome Wikipedia
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Microvascular Complications Of Diabetes, Susceptibility To, 2
OMIM
Molecular Genetics Tong et al. (2008) genotyped 19 SNPs in 11 genes involved in angiogenesis in 374 patients with type 2 diabetes (125853) and both proliferative diabetic retinopathy (PDR) and end-stage renal disease (ESRD) and 239 age- and ethnicity-matched diabetic controls; the only significant association (corrected p = 0.036) was at rs1617640 in the promoter of the EPO gene (133170.0001). To investigate whether rs1617640 was specifically associated with diabetic microvascular complications rather than with complications of type 2 diabetes per se, the authors replicated the study in 365 patients with type 1 diabetes (222100) with both PDR and ESRD, 500 with nephropathy and retinopathy without progression to PDR and ESRD, and 574 type 1 diabetic control patients without nephropathy or retinopathy, and found that the T allele of rs1617640 was significantly associated (p = 2.66 x 10(-8)) with PDR and ESRD; the results were confirmed in a third cohort involving 379 type 1 diabetics with both PDR and nephropathy and 141 diabetic controls (p = 0.021).
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Leprosy, Susceptibility To, 4
OMIM
In a 2-stage genomewide scan of 71 multicase leprosy families (365 individuals) in Brazil, Miller et al. (2004) found suggestive evidence for linkage to chromosomes 6p21.32, 17q22, and 20p13. ... Alcais et al. (2007) stated that their results showed that LTA+80 did not have a substantial role in leprosy susceptibility in individuals over 25 years of age. The A allele of LTA+80 is associated with significantly lower levels of a downstream reporter than the C allele (Knight et al., 2004).CCDC88B, SLC11A1, TLR2, TLR1, IL23R, RAB32, BATF3, LTA, HLA-DRB1, LACC1, CCDC122, TNFSF15, C1orf141, HLA-B, PRKN, TNF, RIPK2, SIGLEC5, IL18R1, IL10, IL1RL1, LINC02571, DELEC1, FILIP1, BBS9, COX4I1, CDH18, SLC2A13, RMI2, SNX20, LINC01091, WASF5P, UBE2V1P15, LINC00690, IFNG, NOD2, VDR, LRRK2, SDHD, PACRG, IL6, MBL2, RBM45, TLR4, MICA, ERBB2, IL4, IL12B, BTNL2, HLA-A, HSPD1, HLA-DQA1, IL2, GEM, S100A6, DDX39A, SLC26A3, MRC1, NGF, CFP, CCL4, CFH, DDX39B, TOLLIP, TGFBR2, KIR3DL1, CTLA4, IL17F, SLC7A9, IL2RA, HSD11B2, APOE, IL1B, IL10RB, CXCL10, IL17A, IL12RB2, BCHE, CD209, ACTG2, IL22, CCR2, TOR1B, FOXP3, NT5C3A, POTEM, CD274, IL37, CYP2E1, PARL, CYP19A1, ACAD8, RNU1-1, NUPR1, H3C9P, SPAG8, PTPN22, NLRP1, ACOT7, ACTG1, POTEKP, EMC3, CR1, ADGB, PWAR1, CASP8, APOA1, STING1, CD14, TNFSF8, CD40, IRGM, TIRAP, CD40LG, DEFB1, ACTBL2, IL26, GAL3ST4, SLC52A2, PINK1, CCR5, ANXA2, ZNF410, HAMP, MAVS, AKR1B10, ANXA1, FMNL1, HLA-DQB1, SOCS1, MASP2, MFN2, PCK1, HIF1A, PAEP, NOS2, NFKBIL1, MPZ, MNAT1, MICB, CIITA, LTB, LGALS3, LDLR, KIR3DL2, KIR2DS1, KDR, ISG20, IL15, IL13RA1, IL13, IL10RA, HLA-C, CXCR2, IL5RA, IL1RN, IL1A, IGF1, HSPE1, POLG, PREP, RNU1-4, FLNA, BMS1, FHL5, IL32, MAP3K14, BCL10, NR1I2, F2R, FCN1, FCN2, HLA-DRB4, FCN3, VEGFA, TOP2A, S100A1, CXCR3, GSTM1, TGFBR1, TGFB1, TFAM, TAP1, STAT3, SOD2, SLAMF1, ACACA, CCL3, S100B, SERPINA3
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Ornithophobia
Wikipedia
The Psychiatric Quarterly . 26 (1): 365–371. doi : 10.1007/BF01568473 . PMID 14949213 . ^ Irena Milosevic; Randi E.
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Chymosin Pseudogene
OMIM
In the process of secretion, preprochymosin, comprising 381 amino acids, is processed by the signal peptidase into an inactive 365-amino acid prochymosin. At low pH, prochymosin undergoes autocatalytic cleavage of 42 N-terminal amino acids, yielding active chymosin.
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Microspherophakia
Wikipedia
"A homozygous mutation in LTBP2 causes isolated microspherophakia". Human Genetics . 128 (4): 365–371. doi : 10.1007/s00439-010-0858-8 .
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Zahn Infarct
Wikipedia
. ^ Matsumoto T, Kuwabara N, Abe H, Fukuda Y, Suyama M, Fujii D, Kojima K, Futagawa S (1992), "Zahn infarct of the liver resulting from occlusive phlebitis in portal vein radicles", American Journal of Gastroenterology , 87 (3): 365–368, PMID 1539574 Reichelt HG (1985), "Partial Budd-Chiari syndrome with Zahn infarct of the liver in venous transmitted tumor thrombosis of a uterine cancer", Röntgen-Blätter (in German), 38 (11): 345–347, PMID 4081553 v t e Ischaemia and infarction Ischemia Location Brain ischemia Heart Large intestine Small intestine Infarction Types Anemic Hemorrhagic Location Heart Brain Spleen Limb Gangrene This article related to pathology is a stub .
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Tempi Syndrome
Wikipedia
Contents 1 Signs and symptoms 2 Cause 3 Diagnosis 4 Treatment 5 History 6 References 7 External links Signs and symptoms [ edit ] TEMPI Symptom T Telangiectasias E Elevated Erythropoietin and Erythrocytosis M Monoclonal gammopathy P Perinephric fluid collections I Intrapulmonary shunting The patients were all diagnosed at middle age. The symptoms were slowly and steadily progressive. ... "TEMPI Syndrome – A Novel Multisystem Disease" . N Engl J Med . 365 (5): 475–477. doi : 10.1056/NEJMc1106670 .
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Idiopathic Scrotal Calcinosis
Wikipedia
Treatment [ edit ] Treatment may involve surgery, [6] which is currently the only recommended intervention. [4] Surgery should include the removal of even small nodules, to prevent the recurrence of the scrotal calcinosis. [4] Prognosis [ edit ] Benign condition Slow progression throughout life Lesions remain discrete and do not become confluent Epidemiology [ edit ] Incidence: uncommon Age: children and young adults History [ edit ] Scrotal calcinosis was first described in 1883 by Lewinski. [4] See also [ edit ] Calcinosis cutis Skin lesion List of cutaneous conditions References [ edit ] ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). ... "Scrotal Calcinosis". New England Journal of Medicine . 365 (7): 647. doi : 10.1056/NEJMicm1013803 .
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Knuckle Pads
Wikipedia
Disease of the skin of human fingers Knuckle pads Specialty Rheumatology Classification D ICD - 10 : M72.1 ICD - 9-CM : 728.79 OMIM : 149100 DiseasesDB : 30724 External resources eMedicine : article/1074379 Knuckle pads (also known as " Heloderma ", meaning similar to the skin of the Gila monster lizard for which it is named) are circumscribed, keratotic, fibrous growths over the dorsa of the interphalangeal joints. [1] They are described as well-defined, round, plaque-like, fibrous thickening that may develop at any age, and grow to be 10 to 15mm in diameter in the course of a few weeks or months, then go away over time. [2] Knuckle pads are sometimes associated with Dupuytren's contracture [3] and camptodactyly , [2] : 595 and histologically, the lesions are fibromas . [2] : 595 [4] Knuckle pads are generally non-responsive to treatment, including corticosteroids , and tend to recur after surgery; however, there has been some effectiveness with intralesional fluorouracil . [5] Contents 1 See also 2 References 3 Further reading 4 External links See also [ edit ] Skin lesion List of cutaneous conditions Garrod's pad References [ edit ] ^ Mackey, SL; Cobb, MW (1994). ... "Pathology of "knuckle pads " " . Virchows Archiv . 365 : 185–191. doi : 10.1007/BF00434037 .
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Barton's Fracture
Wikipedia
Medical Examiner, Philadelphia, 1838, 1: 365–368. External links [ edit ] 01217 at CHORUS Classification D ICD - 10 : S52.5 External resources AO Foundation : – 21-C3 21-C1 – 21-C3 v t e Fractures and cartilage damage General Avulsion fracture Chalkstick fracture Greenstick fracture Open fracture Pathologic fracture Spiral fracture Head Basilar skull fracture Blowout fracture Mandibular fracture Nasal fracture Le Fort fracture of skull Zygomaticomaxillary complex fracture Zygoma fracture Spinal fracture Cervical fracture Jefferson fracture Hangman's fracture Flexion teardrop fracture Clay-shoveler fracture Burst fracture Compression fracture Chance fracture Holdsworth fracture Ribs Rib fracture Sternal fracture Shoulder fracture Clavicle Scapular Arm fracture Humerus fracture : Proximal Supracondylar Holstein–Lewis fracture Forearm fracture : Ulna fracture Monteggia fracture Hume fracture Radius fracture / Distal radius Galeazzi Colles' Smith's Barton's Essex-Lopresti fracture Hand fracture Scaphoid Rolando Bennett's Boxer's Busch's Pelvic fracture Duverney fracture Pipkin fracture Leg Tibia fracture : Bumper fracture Segond fracture Gosselin fracture Toddler's fracture Pilon fracture Plafond fracture Tillaux fracture Fibular fracture : Maisonneuve fracture Le Fort fracture of ankle Bosworth fracture Combined tibia and fibula fracture : Trimalleolar fracture Bimalleolar fracture Pott's fracture Crus fracture : Patella fracture Femoral fracture : Hip fracture Foot fracture Lisfranc Jones March Calcaneal This article about an injury is a stub .
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Al Amyloidosis
Wikipedia
Two thirds of patients with AL amyloidosis are male and less than 5% of patients are under 40 years of age. [4] [13] See also [ edit ] Light chain deposition disease References [ edit ] ^ Gertz MA (June 2004). ... British Journal of Haematology . 140 (4): 365–377. doi : 10.1111/j.1365-2141.2007.06936.x . ... External links [ edit ] Classification D ICD - 10 : E85 ICD - 9-CM : 277.3 OMIM : 254500 MeSH : C531616 DiseasesDB : 315 External resources MedlinePlus : 000533 eMedicine : med/3363 v t e Amyloidosis Common amyloid forming proteins AA ATTR Aβ2M AL Aβ / APP AIAPP ACal APro AANF ACys ABri Systemic amyloidosis AL amyloidosis AA amyloidosis Aβ2M/Haemodialysis-associated AGel/Finnish type AA/Familial Mediterranean fever ATTR/Transthyretin-related hereditary Organ-limited amyloidosis Heart AANF/Isolated atrial Brain Familial amyloid neuropathy ACys+ABri/Cerebral amyloid angiopathy Aβ/Alzheimer's disease Kidney AApoA1+AFib+ALys/Familial renal Skin Primary cutaneous amyloidosis Amyloid purpura Endocrine Thyroid ACal/Medullary thyroid cancer Pituitary APro/Prolactinoma Pancreas AIAPP/Insulinoma AIAPP/Diabetes mellitus type 2 v t e Immunoproliferative immunoglobulin disorders PCDs / PP Plasmacytoma Multiple myeloma ( Plasma cell leukemia ) MGUS IgM ( Macroglobulinemia / Waldenström's macroglobulinemia ) heavy chain ( Heavy chain disease ) light chain ( Primary amyloidosis ) Other hypergammaglobulinemia CryoglobulinemiaCCND1, LINC02343, CBX7, LINC00457, SMARCD3, TTR, DNAH11, CD38, SCT, GDF15, NPPB, SPP1, IGKV2-29, MIR34A, SMN1, SMN2, ST2, TNF, BMS1P20, KRT20, IGKV1-8, BABAM2, GLIPR1, WDHD1, MAGEC2, SLC1A4, PLXNB2, IGKV3D-15, IGKV1D-8, IGKV3-20, PRAME, ALB, SDC1, FGA, BCR, PRDM1, CAT, MS4A1, CDA, CDH1, CRP, CSF3, CYP1B1, DDT, ETFA, GSN, FAS, IGKV@, LGALS3, LGALS4, MDK, MMP1, MMP2, MUC1, MYD88, NCAM1, PFDN5, RPS27A, SAA1
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Acephalgic Migraine
Wikipedia
It is a relatively uncommon variant of migraine in which the patient may experience aura , nausea , photophobia , hemiparesis , and other migraine symptoms , but does not experience headache . [1] It is generally classified as an event fulfilling the conditions of migraine with aura with no (or minimal) headache . [2] [3] It is sometimes distinguished from visual-only migraine aura without headache, also called ocular migraine . [4] Contents 1 Symptoms and misdiagnosis 2 Treatment 3 See also 4 References Symptoms and misdiagnosis [ edit ] Acephalgic migraines can occur in individuals of any age. [5] Some individuals, more commonly male, only experience acephalgic migraine, but frequently patients also experience migraine with headache. [6] Generally, the condition is more than twice as likely to occur in females than males. [7] Pediatric acephalgic migraines are listed along with other childhood periodic syndromes by W.A. ... "Pediatric migraine equivalents: occurrence and clinical features in practice". Pediatric Neurology . 26 (5): 365–8. doi : 10.1016/S0887-8994(01)00416-7 .
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Actinobacillosis
Wikipedia
Actinobacillus suis is an important disease of pigs of all ages and can lead to severe morbidity and sudden death. [3] Contents 1 Causes 2 Differential diagnosis 3 See also 4 References 5 External links Causes [ edit ] The infection is most commonly caused by abrasions on different soft tissues through which the bacteria, Actinobacillus lignieresii, enters. ... Journal of Veterinary Diagnostic Investigation . 26 (3): 365–375. doi : 10.1177/1040638714531766 .
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Erythema Marginatum
Wikipedia
Archives of Disease in Childhood . 30 (152): 359–365. doi : 10.1136/adc.30.152.359 . ISSN 0003-9888 .
- Rolando Fracture Wikipedia
- Papuloerythroderma Of Ofuji Wikipedia
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Alzheimer Disease 2
OMIM
Reiman et al. (2001) found that 10 cognitively normal apoE4 heterozygotes aged 50 to 63 years also had abnormally low measurements of the cerebral metabolic rate for glucose in the same regions as AD patients. ... In a study of 48 kindreds with multiple cases of Alzheimer disease in 2 or more generations and with family age-at-onset means ranging from 41 to 83 years, Schellenberg et al. (1991) found negative lod scores for those families with onset after age 60, those families with onset before age 60, and for Volga German families with mean age of onset of 56. ... Sillen et al. (2006) conducted a genomewide linkage study on 188 individuals with AD from 71 Swedish families, using 365 markers (average intermarker distance 8.97 cM). ... Onset was early in 4 other families tested; 2 had chromosome 21 APP (104760) mutations and 2 showed linkage to chromosome 14, thus representing AD1 (104300) and AD3 (607822), respectively. ... Homozygosity for APOE*E4 was virtually sufficient alone to cause AD by age 80. Bray et al. (2004) applied highly quantitative measures of allele discrimination to cortical RNA from individuals heterozygous for the APOE E2, E3, and E4 alleles.TOMM40, TREM2, ABCA7, APP, APOE, PSEN2, PSEN1, MAPT, SORL1, PRNP, CASP3, BACE1, GSK3B, NCSTN, IDE, IL1B, HFE, A2M, ACE, DHCR24, BIN1, ESR1, ADAM10, ADAMTS1, PGRMC1, VEGFA, ARC, CYP46A1, SLC30A4, VSNL1, PICALM, HMOX1, HLA-DRB5, IGF1R, IGF1, INPP5D, IGF2, MPO, NPY, NOS3, PLAU, PLCG2, PPARG, RELN, MTHFR, PYY, NECTIN2, SLC2A4, IGF2R, SOD2, MAOB, TF, LEP, TFAM, INSR, INS, TNF, TPI1, EPHA1, F2, ENO1, CR1, CASS4, ATP5F1A, CLU, CHRNB2, CHRNA7, MIR766, CD33, IQCK, EIF2S1, MIR505, APOC1, CALM1, MIR100, MIR146A, BDNF, BCL2, MIR375, MIR296, BCHE, MIR708, TPP1, SLC30A6, SNAR-I, DPYSL2, ACHE, CD2AP, GAPDHS, PCDH11X, CYP2D6, MIR4467, CRH, MIR3622B, BAX, AMFR, ABI3, CST3, MS4A4A, WWOX, BRCA2, FANCD2, TFF1, TAS2R64P, CTNNB1, SUCLA2, SNCA, CTSD, RNR2, NEFL, TAS2R62P, SOD1, ITPR3, ITPR2, ITPR1, FLAD1, PSENEN, TP53, CDK5R1, EIF2AK3, UBQLN1, ALG3, PIK3CG, PIK3CA, PIK3CD, SERPINA3, PIK3CB, DOCK3, APLP1, OGDH, CREB1, NOTCH1, CASP6, NGF, CCND1, FOS, DLX4, DLG4, DDIT3, RABGEF1, PEBP1, PYCARD, DAPK2, KCNIP3, CTSB, CSF2, CRMP1, CTSG, EHMT2, ENO2, ERBB4, TMED10, TERF2IP, PTK2B, FCN2, PTGES3, FGF2, ACKR1, DNM1L, SDC3, G6PD, GCHFR, ITM2B, CREBBP, MAP3K8, TRPM7, ADI1, MTCO2P12, UPK3B, ACTB, AKT1, AKT2, ANXA1, APBB1, DNLZ, STS, MIR34A, BRCA1, MIR137, C5AR1, DDR1, CAMK4, TMED10P1, MPEG1, C9orf72, ESCO1, CDCA5, PRRT2, MAP1LC3B, CAT, EHMT1, CNR2, SPPL2B, RAB9A, NRXN3, GFAP, SYNJ1, SERPINB5, CD99, MME, MNAT1, CCL2, RRAS, RPS27, RPS21, RAP1A, PYCR1, COX2, PTS, PTGS2, MTHFD1, MMUT, NCAM1, NFIA, NFIB, MAPK8, MAPK3, PRKCB, PRKCA, PPBP, MED1, NFIC, PPARA, NFIX, PKD1, NOTCH3, NRGN, MEOX2, MEF2A, SPRR2A, TTC3, GRIN2A, DENR, GRIN2B, RAB7A, LRP8, HPRT1, HSP90AA1, VIM, IDUA, UTRN, SUMO1, UBE2I, TTK, TPT1, SULT1E1, IL1A, IL6, IL12A, TSPAN6, TIE1, TGFB1, TG, KNG1, LAMC2, LGALS3, TERT, TERC, STIM1, H3P17
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Androgen Deficiency
Wikipedia
Alternatively, it may be the result of conditions such as androgen insensitivity syndrome or hyperestrogenism . More simply, old age may also be a factor in the development of hypoandrogenism, as androgen levels decline with age. [ citation needed ] Diagnosis [ edit ] Diagnosis of androgenic deficiency in males should be based on symptoms together with at least two measurements of testosterone done first thing in the morning after a period of not eating. [1] In those without symptoms testing is not generally recommended. [1] Androgen deficiency is not usually a checked for diagnosis in healthy women. [5] Treatment [ edit ] See also: Testosterone (medication) Treatment may consist of hormone replacement therapy with androgens in those with symptoms. [1] Treatment mostly just improves sexual function in males. [1] Alternatively, gonadotropin-releasing hormone (GnRH)/ GnRH agonists or gonadotropins may be given (in the case of hypogonadotropic hypoandrogenism). The Food and Drug Administration (FDA) stated in 2015 that neither the benefits nor the safety of testosterone have been established for low testosterone levels due to aging . [6] The FDA has required that testosterone pharmaceutical labels include warning information about the possibility of an increased risk of heart attacks and stroke. [6] v t e Androgen replacement therapy formulations and dosages used in men Route Medication Major brand names Form Dosage Oral Testosterone a – Tablet 400–800 mg/day (in divided doses) Testosterone undecanoate Andriol, Jatenzo Capsule 40–80 mg/2–4x day (with meals) Methyltestosterone b Android, Metandren, Testred Tablet 10–50 mg/day Fluoxymesterone b Halotestin, Ora-Testryl, Ultandren Tablet 5–20 mg/day Metandienone b Dianabol Tablet 5–15 mg/day Mesterolone b Proviron Tablet 25–150 mg/day Buccal Testosterone Striant Tablet 30 mg 2x/day Methyltestosterone b Metandren, Oreton Methyl Tablet 5–25 mg/day Sublingual Testosterone b Testoral Tablet 5–10 mg 1–4x/day Methyltestosterone b Metandren, Oreton Methyl Tablet 10–30 mg/day Intranasal Testosterone Natesto Nasal spray 11 mg 3x/day Transdermal Testosterone AndroGel, Testim, TestoGel Gel 25–125 mg/day Androderm, AndroPatch, TestoPatch Non-scrotal patch 2.5–15 mg/day Testoderm Scrotal patch 4–6 mg/day Axiron Axillary solution 30–120 mg/day Androstanolone ( DHT ) Andractim Gel 100–250 mg/day Rectal Testosterone Rektandron, Testosteron b Suppository 40 mg 2–3x/day Injection ( IM or SC ) Testosterone Andronaq, Sterotate, Virosterone Aqueous suspension 10–50 mg 2–3x/week Testosterone propionate b Testoviron Oil solution 10–50 mg 2–3x/week Testosterone enanthate Delatestryl Oil solution 50–250 mg 1x/1–4 weeks Xyosted Auto-injector 50–100 mg 1x/week Testosterone cypionate Depo-Testosterone Oil solution 50–250 mg 1x/1–4 weeks Testosterone isobutyrate Agovirin Depot Aqueous suspension 50–100 mg 1x/1–2 weeks Testosterone phenylacetate b Perandren, Androject Oil solution 50–200 mg 1x/3–5 weeks Mixed testosterone esters Sustanon 100, Sustanon 250 Oil solution 50–250 mg 1x/2–4 weeks Testosterone undecanoate Aveed, Nebido Oil solution 750–1,000 mg 1x/10–14 weeks Testosterone buciclate a – Aqueous suspension 600–1,000 mg 1x/12–20 weeks Implant Testosterone Testopel Pellet 150–1,200 mg/3–6 months Notes: Men produce about 3 to 11 mg testosterone per day (mean 7 mg/day in young men). ... Androgens in Health and Disease . Humana Press. pp. 365–379. ISBN 978-1-58829-029-8 . Retrieved 11 June 2012 . ^ Wierman ME, Arlt W, Basson R, Davis SR, Miller KK, Murad MH, Rosner W, Santoro N (October 2014). ... "Testosterone Products: Drug Safety Communication - FDA Cautions About Using Testosterone Products for Low Testosterone Due to Aging; Requires Labeling Change to Inform of Possible Increased Risk of Heart Attack And Stroke" .
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Marker Chromosome
Wikipedia
PMID 18252220 . https://web.archive.org/web/20060926021351/http://www.chromodisorder.org/sytrix/card_list.php3?dbid=63&id=365 An International System for Human Cytogenetic Nomenclature, Shaffer, L.G., Tommerup N.