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  • Hiv/aids In Indonesia Wikipedia
    Historically the highest concentration areas have been Papua , Jakarta , East Java , West Java , Bali and Riau . [7] The island of Java, which includes the capital Jakarta, is now home to the highest concentration of HIV cases in Indonesia. Of the 34 provinces spread across the vast territories of Indonesia, two provinces represent more than a quarter (28%) of the national total of people living with HIV – DKI Jakarta and Papua ( [8] A generalised epidemic was already under way in the provinces of Papua and West Papua , where a population-based survey found an adult-prevalence rate of 2.4% in 2006. ... According to the Indonesian Ministry of Health, surveys reported that more than 40% of injecting drug users in Jakarta tested positive for HIV, and about 13% tested positive in West Java . ... Retrieved 17 April 2018 . ^ "Hapless Trade Minister Rahmat Scorned After Saying Used Clothes Transmit HIV - Jakarta Globe" . Jakartaglobe.beritasatu.com . 4 February 2015 . Retrieved 17 April 2018 . ^ "Sex education must be taught in schools: Child protection commission" . The Jakarta Post . Retrieved 17 April 2018 . ^ Schonhardt, Sara (17 April 2018).
  • Passive–aggressive Personality Disorder Wikipedia
    Murphy and Loriann Oberlin . [4] Alternatively individuals may simply have difficulty being as directly aggressive or assertive as others. Martin Kantor suggests three areas that contribute to passive–aggressive anger in individuals: conflicts about dependency, control, and competition, and that a person may be termed passive–aggressive if they behave so to few people on most occasions. [5] Murphy and Oberlin also see passive aggression as part of a larger umbrella of hidden anger stemming from ten traits of the angry child or adult. ... (no longer a valid diagnosis in DSM) Treatment [ edit ] Psychiatrist Kantor suggests a treatment approach using psychodynamic , supportive , cognitive , behavioral and interpersonal therapeutic methods. ... Psychiatry , 56 (7): 600–06, doi : 10.1001/archpsyc.56.7.600 , PMID 10401504 ^ Tim, Murphy; Hoff Oberlin, Loriann (2005), Overcoming passive aggression: how to stop hidden anger from spoiling your relationships, career and happiness , New York: Marlowe & Company, p. 48, ISBN 978-1-56924-361-9 , retrieved April 27, 2010 ^ Kantor 2002 , pp. xvi–xvii, 5. ^ Tim, Murphy; Hoff Oberlin, Loriann (2005). [ page needed ] ^ a b "Disorders of adult personality and behaviour (F60–F69). ... CS1 maint: multiple names: authors list ( link ) ^ Kantor 2002 , p. 115. ^ Lane, C (1 February 2009), "The Surprising History of Passive–aggressive Personality Disorder" (PDF) , Theory & Psychology , 19 (1): 55–70, CiteSeerX 10.1.1.532.5027 , doi : 10.1177/0959354308101419 , S2CID 147019317 , archived (PDF) from the original on 2017-09-23 , retrieved 2017-12-06 Bibliography [ edit ] Kantor, Martin (2002), Passive-aggression: a guide for the therapist, the patient and the victim , Westport, CT: Praeger Publishers , ISBN 978-0-275-97422-0 , retrieved December 6, 2017 .
  • Cerebral Creatine Deficiency Wikipedia
    Amino Acids . 40 (5): 1315–1324. doi : 10.1007/s00726-011-0852-z . PMID 21390529 . ^ a b c Schulze, Andreas (2009).
    ABHD5, PNPLA2, ANO10, TTR, LEXM, CD40LG, AADAC, LPIN2, PLIN1, S100A7, SHOX, SLC22A5, DGAT1, CIC, KDM4A, PEMT, PDGFRB, AGK, PNPLA1, MICOS10-NBL1, SERPINA1, PARN, PLIN2, CPT2, AGT, APOA1, CCND1, CD80, CD86, CDK4, CDKN2A, DCX, NBL1, ESR1, ETFA, ETFB, ETFDH, IFNG, ITGA2B, MDM2, H3P10
    • Chanarin-Dorfman Syndrome MedlinePlus
      Chanarin-Dorfman syndrome is a condition in which fats (lipids) are stored abnormally in the body. Affected individuals cannot break down certain fats called triglycerides, and these fats accumulate in organs and tissues, including skin, liver, muscles, intestine, eyes, and ears. People with this condition also have dry, scaly skin (ichthyosis), which is usually present at birth. Additional features of this condition include an enlarged liver (hepatomegaly), clouding of the lens of the eyes (cataracts ), difficulty with coordinating movements (ataxia), hearing loss, short stature, muscle weakness (myopathy), involuntary movement of the eyes (nystagmus), and mild intellectual disability. The signs and symptoms vary greatly among individuals with Chanarin-Dorfman syndrome.
    • Neutral Lipid Storage Disease Orphanet
      Neutral lipid storage disease (NLSD) refers to a group of diseases characterized by a deficit in the degradation of cytoplasmic triglycerides and their accumulation in cytoplasmic lipid vacuoles in most tissues of the body. The group is heterogeneous: currently cases of NLSD with icthyosis (NLSDI/Dorfman-Chanarin disease; see this term) and NLSD with myopathy (NLSDM/neutral lipid storage myopathy; see this term) can be distinguished. Epidemiology The group of diseases is very rare and the prevalence is unknown (around 50 cases have been reported in medical literature, of which 3 had NLSDM) because of the vagueness of the descriptions. Clinical description In NLSDI, generalized ichthyosis occurs in 95% of cases, moderate myopathic syndrome (or abnormal serum muscle enzyme levels), intellectual deficit and moderate hepatomegaly (or functional impairment of the liver) occur in 60% of cases, ocular (cataract, retinopathy) and hearing abnormalities (deafness) occur in 40% of cases, and neuropathy and short stature occur in 20% of cases. Etiology NLSDI/Dorfman-Chanarin disease is caused by mutations in the ABHD5 gene (3p21), NLSDM by mutations in the PNPLA2/ATGL gene (localized to 11p15.5).
    • Neutral Lipid Storage Disease Wikipedia
      Neutral lipid storage disease Other names Chanarin–Dorfman syndrome Presence of lipid vacuoles in granulocytes in Chanarin-Dorfman syndrome (also known as Jordans' anomaly ) Neutral lipid storage disease (also known as Chanarin–Dorfman syndrome ) is a congenital autosomal recessive disorder characterized by accumulation of triglycerides in the cytoplasm of leukocytes[1], (Jordan’s Anomaly) muscle, liver, fibroblasts , and other tissues. It commonly occurs as one of two subtypes, cardiomyopathic neutral lipid storage disease (NLSD-M), or ichthyotic neutral lipid storage disease (NLSD-I) which is also known as Chanarin–Dorfman syndrome), which are characterized primarily by myopathy and ichthyosis , respectively. Normally, the ichthyosis that is present is typically non-bullous congenital ichthyosiform erythroderma which appears as white scaling. It has been associated genetically with mutations in the CGI58 gene, (for NLSD-I), or the ATGL gene (for NLSD-M.) [1] [2] [3] Contents 1 Cause 1.1 Genetics 2 Pathophysiology 3 Diagnosis 4 Treatment 5 Epidemiology 6 History 7 See also 8 References 9 External links Cause [ edit ] Neutral lipid storage disease is caused by the abnormal and excessive accumulation of lipids in certain bodily tissues, including the liver, the heart, and muscle. [4] Normally, these lipids are stored as lipid droplets and are normally used for metabolism, cell signaling and trafficking of vesicles. [5] Neutral lipid storage disease is a disease that is diagnosed with the simultaneous occurrence of myopathy and/or ichthyosis. Myopathy is defined as a disease of the muscle tissue. Ichthyosis is a skin related disease in which the skin becomes very scaly, thick, and dry.
    • Neutral Lipid Storage Disease With Ichthyosis Orphanet
      A form of neutral lipid storage disease characterized by the accumulation of lipid vacuoles in leukocytes (so-called Jordan's anomaly seen in peripheral blood smears) and a variety of other cell types. The clinical picture consists of congenital ichthyosis of the congenital ichthyosiform erythroderma type together with variable multisystem involvement. Manifestations include hepatosplenomegaly, myopathy, intestinal disease, growth retardation, cataracts, sensorineural hearing loss, and intellectual disability, among others.
    • Chanarin-Dorfman Syndrome OMIM
      A number sign (#) is used with this entry because Chanarin-Dorfman syndrome, a rare form of nonbullous congenital ichthyosiform erythroderma (NCIE; see 242300), can be caused by homozygous mutation in the CGI58 gene (ABHD5; 604780). Another form of neutral lipid storage disease without ichthyosis but with myopathy (NLSDM; 610717) is caused by mutation in the PNPLA2 gene (609059). Clinical Features In a 5-year-old girl, Angelini et al. (1980) identified a syndrome, presumably inherited as an autosomal recessive, characterized by congenital ichthyosis, hepatosplenomegaly, vacuolated granulocytes (Jordans anomaly), and myopathy. Pathologic, ultrastructural and biochemical studies showed nonlysosomal, multisystem triglyceride storage. Cultured fibroblasts showed an increased uptake but decreased oxidation of labeled oleate.
    • Chanarin-Dorfman Syndrome GARD
      Chanarin-Dorfman syndrome is an inherited condition in which fats are stored abnormally in the body. Affected individuals cannot break down certain fats called triglycerides . These fats accumulate in organs and tissues, including skin, liver, muscles, intestine, eyes, and ears. At birth, affected individuals usually present with dry, scaly skin. Additional features include an enlarged liver, cataracts, difficulty with coordinating movements (ataxia), hearing loss, short stature, muscle weakness, nystagmus, and mild intellectual disability. The signs and symptoms vary greatly among individuals with this condition.
  • Doping At The Asian Games Wikipedia
    Contents 1 Asian Games 1.1 1974 Tehran 1.2 1994 Hiroshima 1.3 1998 Bangkok 1.4 2002 Busan 1.5 2006 Doha 1.6 2010 Guangzhou 1.7 2014 Incheon 1.8 2018 Jakarta–Palembang 2 See also 3 References Asian Games [ edit ] 1974 Tehran [ edit ] Main article: 1974 Asian Games Name NOC Sport Banned substance Medals Ref Oh Han-nam South Korea Volleyball (Men) [1] Masushi Ouchi Japan Weightlifting Stimulant (Men's 90 kg) (Men's snatch 90 kg) (Men's clean & jerk 90 kg) [2] Kim Joong-iI North Korea Weightlifting Stimulant (Men's 110 kg) (Men's snatch 110 kg) (Men's clean & jerk 110 kg) [3] 1994 Hiroshima [ edit ] Main article: 1994 Asian Games Name NOC Sport Banned substance Medals Ref Han Qing China Athletics Dihydrotestosterone (Women's 400 m hurdles) [4] Zhang Lei China Canoeing Dihydrotestosterone (Men's C-1 500 m) (Men's C-1 1000 m) (Men's C-2 500 m) [4] Qiu Suoren China Canoeing Dihydrotestosterone (Men's C-2 1000 m) [4] Wang Yan China Cycling Dihydrotestosterone (Women's sprint) [4] Sirisak Kadalee Thailand Football Stimulant [5] Fu Yong China Swimming Dihydrotestosterone (Men's 400 m individual medley) [6] Hu Bin China Swimming Dihydrotestosterone (Men's 50 m freestyle) [6] Lü Bin China Swimming Dihydrotestosterone (Women's 50 m freestyle) (Women's 200 m freestyle) (Women's 200 m individual medley) (Women's 4 × 100 m freestyle relay) (Women's 100 m freestyle) (Women's 100 m backstroke) [6] Xiong Guoming China Swimming Dihydrotestosterone (Men's 200 m freestyle) (Men's 200 m individual medley) (Men's 400 m individual medley) (Men's 4 × 200 m freestyle relay) (Men's 4 × 100 m freestyle relay) [6] Yang Aihua China Swimming Dihydrotestosterone (Women's 400 m freestyle) [6] Zhang Bin China Swimming Dihydrotestosterone (Men's 200 m butterfly) [6] Zhou Guanbin China Swimming Dihydrotestosterone (Women's 400 m freestyle) (Women's 800 m freestyle) [6] 1998 Bangkok [ edit ] Main article: 1998 Asian Games Name NOC Sport Banned substance Medals Ref Abdullah Sabt Ghulam United Arab Emirates Athletics Ephedrine [7] Fakhruddin Abdulmajid United Arab Emirates Karate Ephedrine (Men's kumite 75 kg) [7] Ayed Khawaldeh Jordan Weightlifting Triamterene [8] Jaber Al-Ajmi Kuwait Weightlifting Nandrolone [8] 2002 Busan [ edit ] Main article: 2002 Asian Games Name NOC Sport Banned substance Medals Ref Youssef El-Zein Lebanon Bodybuilding Missed the test ( Men's +90 kg ) [9] 2006 Doha [ edit ] Main article: 2006 Asian Games Name NOC Sport Banned substance Medals Ref Santhi Soundarajan India Athletics Male hormone ( Women's 800 m ) [10] Sayed Faisal Husain Bahrain Bodybuilding ( Men's 70 kg ) [11] Faez Abdul-Hassan Iraq Bodybuilding Nandrolone [12] Kim Myong-hun South Korea Bodybuilding ( Men's 90 kg ) [13] Salem Ghanem Al-Shamsi United Arab Emirates Bodybuilding [14] Kyi Kyi Than Myanmar Weightlifting Diuretic [12] Mya Sanda Oo Myanmar Weightlifting Metabolite ( Women's 75 kg ) [12] Elmira Ramileva Uzbekistan Weightlifting Stanozolol [12] Aleksandr Urinov Uzbekistan Weightlifting Cannabis [12] 2010 Guangzhou [ edit ] Main article: 2010 Asian Games Name NOC Sport Banned substance Medals Ref Suresh Sathya India Athletics Nandrolone [15] Ahmed Dheeb Qatar Athletics Testosterone ( Men's discus throw ) [16] Abdelnasser Awajna Palestine Athletics Norandrosterone [16] Masoud Rigi Iran Boxing Nandrolone [17] Shokir Muminov Uzbekistan Judo Methylhexanamine ( Men's 81 kg ) [18] Jakhongir Muminov Uzbekistan Wrestling Methylhexanamine [19] 2014 Incheon [ edit ] Main article: 2014 Asian Games Name NOC Sport Banned substance Medals Ref Betlhem Desalegn United Arab Emirates Athletics Biological passport abnormalities [20] Khurshed Beknazarov Tajikistan Football Methylhexanamine [21] Nouraddin Al-Kurdi Syria Karate Clenbuterol [22] Yi Sophany Cambodia Soft tennis Sibutramine [23] Park Tae-hwan South Korea Swimming Nebido ( Men's 100 m freestyle ) ( Men's 200 m freestyle ) ( Men's 400 m freestyle ) ( Men's 4 × 100 m freestyle relay ) ( Men's 4 × 200 m freestyle relay ) ( Men's 4 × 100 m medley relay ) [24] Mohammed Jassim Iraq Weightlifting Etiocholanolone [22] Tai Cheau Xuen Malaysia Wushu Sibutramine ( Women's nanquan ) [25] 2018 Jakarta–Palembang [ edit ] Main article: 2018 Asian Games Name NOC Sport Banned substance Medals Ref Kemi Adekoya Bahrain Athletics Stanozolol ( Women's 400 m hurdles ) ( Mixed 4 × 400 m relay ) [26] Sanjivani Jadhav India Athletics Probenecid [26] Nirmala Sheoran India Athletics Drostanolone and Metenolone [27] Kumush Yuldashova Uzbekistan Kurash Stanozolol ( Women's 78 kg ) [28] Pürevdorjiin Orkhon Mongolia Wrestling Stanozolol ( Women's freestyle 62 kg ) [29] Rüstem Nazarow Turkmenistan Wrestling Furosemide [30] See also [ edit ] Asia portal Sports portal Doping at the Commonwealth Games Doping at the Olympics References [ edit ] ^ "South Korea's volleyball silver in the balance" . ... Retrieved 12 April 2013 . ^ "Bodybuilder Syafrizaldy gets Asiad silver" . The Jakarta Post . 16 May 2007. Archived from the original on 7 June 2011 .
  • Cyanide Poisoning Wikipedia
    On 5 December 2009, a fire in the night club Lame Horse (Khromaya Loshad) in the Russian city of Perm took the lives of 156 people. ... One of the main causes of death was poisoning from cyanide and other toxic gases released by the burning of plastic and polyurethane foam used in the construction of club interiors. Taking into account the number of deaths, this was the largest fire in post-Soviet Russia. [ citation needed ] On 27 January 2013, a fire at the Kiss nightclub in the city of Santa Maria , in the south of Brazil , caused the poisoning of hundreds of young people by cyanide released by the combustion of soundproofing foam made with polyurethane . ... They also offered courses to the SS in the safe handling and use of the material for fumigation purposes. [50] In April 1941, the German agriculture and interior ministries designated the SS as an authorized applier of the chemical, and thus they were able to use it without any further training or governmental oversight. [51] Hydrogen cyanide gas has been used for judicial execution in some states of the United States, where cyanide was generated by reaction between potassium cyanide (or sodium cyanide [52] [53] ) dropped into a compartment containing sulfuric acid , directly below the chair in the gas chamber . [54] Suicide [ edit ] Cyanide salts are sometimes used as fast-acting suicide devices. ... Robert Ferrante is appealing his conviction. [65] Mirna Salihin died in hospital on 6 January 2016, after drinking a Vietnamese iced coffee at a cafe in a shopping mall in Jakarta . Police reports claim that cyanide poisoning was the most likely cause of her death. ... Terrorism [ edit ] In 1995, a device was discovered in a restroom in the Kayabacho Tokyo subway station, consisting of bags of sodium cyanide and sulfuric acid with a remote controlled motor to rupture them in what was believed to be an attempt by the Aum Shinrikyo cult to produce toxic amounts of hydrogen cyanide gas. [68] In 2003, Al Qaeda reportedly planned to release cyanide gas into the New York City Subway system. The attack was supposedly aborted because there would not be enough casualties. [69] Research [ edit ] Cobinamide is the final compound in the biosynthesis of cobalamin.
  • Abortion In Mexico Wikipedia
    "The Decriminalisation of Abortion in Mexico City: How Did Abortion Rights Become a Political Priority?". ... Christian Science Monitor . Mexico City . Retrieved 2009-10-17 . ^ a b "State Legislation" . ... "Judges uphold abortion rights in Mexico City" . The Guardian . Retrieved 2009-10-17 . ^ "Population of Mexico City as a percentage of the national population of Mexico" . ... El Financiero en línea (in Spanish). Mexico City. 2009-10-13. Archived from the original on 2018-10-02 . ... PMID 21972670 . ^ a b ELISABETH MALKIN; NACHA CATTAN (24 August 2008). "Mexico City Struggles With Law on Abortion" .
  • Alcohol Myopia Wikipedia
    PMID 14647967 . S2CID 25817991 . ^ Schmitt, WA; CA Brinkley; JP Newman (1999). "Testin Demasio's somatic marker hypothesis with psychopathic individuals: risk takers or risk averse?". ... Brain Research . 508 (1): 65–69. doi : 10.1016/0006-8993(90)91118-z . PMID 2337793 . ^ Sevincer, A. Timur; Oettingen, Gabriele; Lerner, Tobias (2012). ... CiteSeerX 10.1.1.380.3494 . doi : 10.1037/a0025931 . PMID 22004115 . ^ Sevincer, A. Timur; Oettingen, Gabriele (2009). "Alcohol breeds empty goal commitments".
  • Klippel-Trenaunay-Weber Syndrome OMIM
    Subsequent progression to right leg hypertrophy was noted in the first 5 years of life. Timur et al. (2004) identified a de novo supernumerary ring chromosome in a patient with mild mental retardation, long tapering fingers, elongated and thin feet, and KTS. ... The de novo translocation t(8;14)(q22.3;q13), reported by Timur et al. (2000) and Wang et al. (2001), points to a pair of chromosomes different from those focused on by Whelan et al. (1995) as the possible site of the Klippel-Trenaunay gene.
    AGGF1, SMOC1, PIK3CA, RASA1, ROGDI, AKT1, IGF2, LMX1B, IKBKG, KCNQ1OT1, DKK1, SOST, H19, KTWS
    • Capillary Malformation-Arteriovenous Malformation 1 OMIM
      A number sign (#) is used with this entry because of evidence that capillary malformation-arteriovenous malformation-1 (CMAVM1) is caused by heterozygous mutation in the RASA1 gene (139150) on chromosome 5q14. Description Capillary malformation-arteriovenous malformation-1 is an autosomal dominant disorder characterized by atypical capillary malformations (CMs), often in association with fast-flow vascular malformations, including arteriovenous malformations (AVMs) and arteriovenous fistulas (AVFs), and Parkes Weber syndrome (PKWS). The CMs are usually multifocal and are surrounded by a pale halo with a central red dot; they increase in number with age. The AVMs generally occur in the brain or on the face or extremities. Intracranial AVMs include vein of Galen aneurysmal malformations (VGAMs). Parkes Weber syndrome is a specific type of CMAVM that presents with limb overgrowth, more commonly affecting one of the lower extremities (Eerola et al., 2003; Revencu et al., 2013; Johnson and Navarro, 2017).
    • Klippel-Trenaunay Syndrome GARD
      Klippel-Trenaunay syndrome (KTS) is a syndrome that affects the development of blood vessels, soft tissues, and bones. This syndrome has three characteristic features: a red birthmark called a port-wine stain , overgrowth of soft tissues and bones, and vein malformations such as varicose veins or malformations of deep veins in the limbs. The overgrowth of bones and soft tissues usually begins in infancy and is most often only affects one leg. However, it can also affect the arms or sometimes the upper body area (torso). The overgrowth can cause pain, a feeling of heaviness, and make the affected leg (or arm) hard to move.
    • Angioosteohypertrophic Syndrome Orphanet
      A congenital vascular bone syndrome (CVBS) characterized by the presence of a vascular malformation in a limb, mainly of the arteriovenous type, which results in overgrowth of the affected limb. Epidemiology Prevalence is unknown but around 1,000 cases have been reported in the literature so far. Clinical description The affected limb may show overgrowth in comparison with the contralateral limb and the extent of this limb length discrepancy (LLD) may vary from a slight difference to 10 cm or more. The growth effect may be manifested in only one bone (mainly the femur or tibia) or, in some cases, affect the whole limb. The LLD may become apparent during infancy, childhood or adolescence and is clearly visible by comparison of the level of the gluteal and posterior knee folds.
    • Klippel–trénaunay Syndrome Wikipedia
      . ^ Klippel–Trenaunay syndrome: Spectrum and management ^ Tian XL, Kadaba R, You SA, Liu M, Timur AA, Yang L, Chen Q, Szafranski P, Rao S, Wu L, Housman DE, DiCorleto PE, Driscoll DJ, Borrow J, Wang Q (2004). ... Archived from the original (PDF) on December 9, 2006. ^ Wang, Q.; Timur, A.A.; Szafranski, P.; Sadgephour, A.; Jurecic, V.; Cowell, J.; Baldini, A.; Driscoll, D.J. (2001).
    • Klippel-Trenaunay Syndrome Mayo Clinic
      Overview Klippel-Trenaunay (klih-PEL tray-no-NAY) syndrome ― also called KTS ― is a rare disorder found at birth (congenital) involving problems in the development of certain blood vessels, soft tissues (such as skin and muscles), bones and sometimes the lymphatic system. The main features include a red birthmark (port-wine stain), ranging in color from pink to reddish-purple, atypical vein or lymphatic development (malformations), and overgrowth of tissues and bones. These findings most often affect one leg but may occur in an arm or elsewhere. Although there is no cure for KTS , treatment goals are to improve symptoms and prevent complications. Symptoms People who have KTS may have the following features, which can range from mild to more extensive: Port-wine stain.
    • Klippel-Trenaunay Syndrome MedlinePlus
      Klippel-Trenaunay syndrome is a condition that affects the development of blood vessels, soft tissues (such as skin and muscles), and bones. The disorder has three characteristic features: a red birthmark called a port-wine stain, abnormal overgrowth of soft tissues and bones, and vein malformations. Most people with Klippel-Trenaunay syndrome are born with a port-wine stain. This type of birthmark is caused by swelling of small blood vessels near the surface of the skin. Port-wine stains are typically flat and can vary from pale pink to deep maroon in color.
  • Alopecia, Androgenetic, 1 OMIM
    TDT results showed a marginally significant association between androgenetic alopecia and variants 3379-29G/T (P = 0.024) and 2611-68C/T (P = 0.047). These results, however, did not remain significant after applying the conservative Bonferroni correction for multiple testing.
    SRD5A2, AR, ABCC2, SUPV3L1, VDR, ZFP36, MTHFR, TNFRSF10A, BRD4, ZDHHC13, HR, PRKAR1A, CRH, PARP1, RHOA, WNT10A, C1orf127, FAF1, MKLN1-AS, TBX15, HOXD-AS2, ARL17B, LINC01432, SSPN, SLC14A2, FAM53B, EMC2, HDAC9, EDAR, MAPT-AS1, DRAIC, DKK2, KLF15, MEMO1, RSPO2, KANSL1, MRPS22, LINC00670, LRMDA, OFCC1, DPY30, GORAB, SPPL2C, THADA, GORAB-AS1, EBF1, RUNX1, MAPT, MKLN1, EIF3E, OPHN1, IRF4, FGF5, AGA, EDA2R, KLK3, TGFB1, GGCT, CD200, DKK1, CTNNB1, IGF1, CD34, DPP4, CYP27B1, COX8A, CRP, COL17A1, CARD14, PRNP, NLRP3, FGF2, CDKN2A, MS4A1, CASP3, C4BPA, MIR223, MIR451A, MIR146B, BDNF, XIAP, AGXT, AGT, AKR1C4, IL1B, KRT20, VEGFA, PTPN1, SHBG, SRD5A1, PPARA, ABCB1, OTC, PRDX2, TGFB1I1, TLR4, TNF, TP53, WNT10B, GHR, NFE2L2, NCOA4, LEP, KRT5, ABCB6, DHRS9, IL17A, MMRN1, TBC1D9, PTGDS, HPGDS, TGFBR1
    • Pattern Hair Loss Wikipedia
      Pattern hair loss Other names Male pattern baldness; Female pattern baldness; Androgenic alopecia; Androgenetic alopecia Male-pattern hair loss shown on the vertex of the scalp Specialty Dermatology , plastic surgery Pattern hair loss is hair loss that primarily affects the top and front of the scalp. [1] In male-pattern hair loss ( MPHL ), the hair loss often presents itself as either a receding hairline, loss of hair on the crown ( vertex ) of the scalp or a combination of both, while in female-pattern hair loss ( FPHL ), it typically presents as a thinning of the hair. [1] Male pattern hair loss seems to be due to a combination of genetics and circulating androgens . [1] The cause in female pattern hair loss remains unclear. [1] Management may include simply accepting the condition. [1] Otherwise, common medical treatments include minoxidil , finasteride , dutasteride , or hair transplant surgery . [1] Use of finasteride and dutasteride in women is not well-studied, and it may result in birth defects if taken during pregnancy . [1] Pattern hair loss by the age of 50 affects about half of males and a quarter of females. [1] It is the most common cause of hair loss . Contents 1 Signs and symptoms 2 Causes 2.1 Hormones and genes 3 Diagnosis 4 Treatment 4.1 Androgen-dependent 4.2 Androgen-independent 4.3 Female pattern 4.4 Procedures 4.5 Alternative therapies 5 Prognosis 5.1 Psychological 6 Epidemiology 7 Society and culture 7.1 Myths 7.1.1 Weight training and other types of physical activity cause baldness 7.1.2 Baldness can be caused by emotional stress, sleep deprivation, etc. 7.1.3 Bald men are more 'virile' or sexually active than others 7.1.4 Frequent ejaculation causes baldness 7.2 Names 8 Other animals 9 References 10 External links Signs and symptoms [ edit ] Classic male-pattern hair loss begins above the temples and at the vertex ( calvaria ) of the scalp . As it progresses, a rim of hair at the sides and rear of the head remains. This has been referred to as a 'Hippocratic wreath', and rarely progresses to complete baldness. [2] Pattern hair loss is classified as a form of non-scarring hair loss. Female-pattern hair loss more often causes diffuse thinning without hairline recession; similar to its male counterpart, female androgenic alopecia rarely leads to total hair loss . [3] The Ludwig scale grades severity of female-pattern hair loss.
    • Androgenetic Alopecia MedlinePlus
      Androgenetic alopecia is a common form of hair loss in both men and women. In men, this condition is also known as male-pattern baldness. Hair is lost in a well-defined pattern, beginning above both temples. Over time, the hairline recedes to form a characteristic "M" shape. Hair also thins at the crown (near the top of the head), often progressing to partial or complete baldness. The pattern of hair loss in women differs from male-pattern baldness. In women, the hair becomes thinner all over the head, and the hairline does not recede.
  • Fumarase Deficiency Wikipedia
    You can help by adding to it . ( July 2017 ) Treatment [ edit ] There is a deficiency of malate in patients because fumarase enzyme can't convert fumarate into it therefore treatment is with oral malic acid which will allow the Krebs cycle to continue, and eventually make ATP. [ citation needed ] Epidemiology [ edit ] Fumarase deficiency is extremely rare - until around 1990 there had only been 13 diagnosed and identified cases worldwide. [ citation needed ] A cluster of 20 cases has since been documented in the twin towns of Colorado City, Arizona and Hildale, Utah among an inbred community of 10,000 members of the Fundamentalist Church of Jesus Christ of Latter Day Saints . [11] [12] [13] [14] Nicknamed "Polygamist's Down's", the syndrome has been blamed on cousin marriage , but in a larger sense is related to the reproductive isolation of a community among whom 85% are blood relatives of John Y. ... "Fumarate Hydratase Deficiency" . GeneReviews . Seattle WA: University of Washington . PMID 20301679 . ^ Online Mendelian Inheritance in Man (OMIM): Fumarase Deficiency - 606812 ^ Devlin, Thomas M. (2006). ... "Hereditary Leiomyomatosis and Renal Cell Cancer" . GeneReviews . Seattle WA: University of Washington . PMID 20301430 .
    FH, CD59
  • Disseminated Superficial Actinic Porokeratosis Wikipedia
    The thread-like ring is very thin, much like fabric thread for sewing, and raised such that it is both palpable and visible. The interior of the ring may be rough like sandpaper, or smooth. The interior is often discolored, though colors vary from patient to patient.
    SART3, MVD, FDPS, MVK, PMVK, SLC17A9, TP53, XRS, GGPS1, ARPC3, SSH1
    • Porokeratosis Wikipedia
      Porokeratosis A porokeratosis lesion in a patient with disseminated superficial actinic porokeratosis . Specialty Pediatrics , dermatology Porokeratosis is a specific disorder of keratinization that is characterized histologically by the presence of a cornoid lamella, a thin column of closely stacked, parakeratotic cells extending through the stratum corneum with a thin or absent granular layer. [1] : 532 Contents 1 Types 2 Genetics 3 Diagnosis 3.1 Pathology 4 Treatment 5 See also 6 References 7 External links Types [ edit ] Porokeratosis may be divided into the following clinical types: [1] : 532 Plaque-type porokeratosis (also known as "Classic porokeratosis" and "Porokeratosis of Mibelli" [2] ) is characterized by skin lesions that start as small, brownish papules that slowly enlarge to form irregular, annular, hyperkeratotic or verrucous plaques. [1] : 533 [3] : 566 Sometimes they may show gross overgrowth and even horn-like structures may develop. [4] Skin malignancy, although rare, is reported from all types of porokeratosis. Squamous cell carcinomas have been reported to develop in Mibelli's type porokeratosis over partianal areas involving anal mucosa. This was the first report mentioning mucosal malignancy in any form of porokeratosis. [4] Disseminated superficial porokeratosis is a more generalized processes and involves mainly the extremities in a bilateral, symmetric fashion. [1] : 533 In about 50% of cases, skin lesions only develop in sun-exposed areas, and this is referred to as disseminated superficial actinic porokeratosis [1] : 533 Porokeratosis palmaris et plantaris disseminata is characterized by skin lesions that are superficial, small, relatively uniform, and demarcated by a distinct peripheral ridge of no more than 1mm in height. [1] : 534 [2] : 1668 [3] : 567 Linear porokeratosis is characterized clinically skin lesions are identical to those of classic porokeratosis, including lichenoid papules, annular lesions, hyperkeratotic plaques with central atrophy, and the characteristic peripheral ridge. [1] [2] : 1668 [3] : 567 Punctate porokeratosis is a skin condition associated with either classic porokeratosis or linear porokeratosis types of porokeratosis, and is characterized by multiple, minute, and discrete punctate, hyperkeratotic, seed-like skin lesions surrounded by a thin, raised margin on the palms and soles. [1] : 535 [2] : 1668 Porokeratosis plantaris discreta is a skin condition that occurs in adults, with a 4:1 female preponderance, characterized by a sharply marginated, rubbery, wide-based papules. [3] : 213 It is also known as "Steinberg's lesion". [5] It was characterized in 1970. [6] Genetics [ edit ] Linear porokeratosis has been associated with mutations in the PMVK and MVD genes. [7] The PMVK gene encodes the enzyme phosphomevalonate kinase and the MVD gene encodes the enzyme diphosphomevalonate decarboxylase . Diagnosis [ edit ] Pathology [ edit ] Micrograph of a case of porokeratosis showing a characteristic cornoid lamella (dark pink/red structure in the right/upper portion of the image).
  • 2016 Munich Shooting Wikipedia
    Police reportedly used a robot to examine it, [28] and a total of 300 rounds of ammunition were found inside. [29] Police officials warned of "an acute terror situation" and initially thought that there were up to three attackers, but later confirmed that there was only one gunman. [10] [30] The Munich U-Bahn , tram service, bus service, and services on the central portion of the S-Bahn in Munich were stopped. [31] [32] Munich main station was evacuated and all trains were cancelled in and out of Munich. Regional and inter-city trains ceased their service to and from the region of the shooting. [33] Deutsche Bahn provided accommodation trains for stranded commuters and tourists where they could seek refuge. ... He said that he had spent more than four hours in the operations centre on 22 July, and thanked the forces for acting with professionalism and calm. The Interior Minister of Bavaria, Joachim Herrmann , announced an investigation into why there had been numerous false alarms. [86] The German Depression-Help Trust ( Stiftung Deutsche Depressionshilfe ) warned of stigmatizing mentally ill people in reaction to the shooting. [87] After the shooter was revealed to have been born in Germany, the right-wing politician André Poggenburg was condemned and mocked in German media for having previously blamed Merkel's open refugee policy for the shooting. [88] International [ edit ] The U.S. Department of State warned Americans in Munich to "shelter in place". [89] President Barack Obama said in a statement that he pledged support for those affected by the shooting. [28] [90] [91] Czech Interior Minister Milan Chovanec said his country would reinforce its borders to prevent the perpetrator(s) from fleeing into that country, according to German television station n-tv . [27] The Czech Foreign Ministry set up an emergency hotline and urged Czechs to avoid public places. [92] The Iranian Ministry of Foreign Affairs condemned the attack. ... "Munich shooting: 'Shots fired' at OEZ shopping centre in German city" . The Independent . Retrieved 22 July 2016 . ^ "Shooter who killed 9 in Munich was 18-year-old with dual Iranian German nationality" . ... Written inquiry of Katharina Schulze from Mai 2, 2018 with answers of the Bavarian Ministry of the Interior with understanding of the Bavarian Ministry of Justice from 24 July 2018. ^ Joshua Kellogg (17 April 2018).
  • Echopraxia Wikipedia
    . ^ Tanner CM, Chamberland J (May 2001). "Latah in Jakarta, Indonesia". Mov. Disord . 16 (3): 526–9. doi : 10.1002/mds.1088 .
  • Chandler's Syndrome GARD
    Chandler's syndrome is a rare eye disorder in which the single layer of cells lining the interior of the cornea proliferates, causing changes within the iris, corneal swelling, and unusually high pressure in the eye (glaucoma).
    SLC4A11, ZEB1, COL4A3, COL8A2, CDK13, OVOL2
    • Chandler Syndrome Orphanet
      A clinical variant of iridocorneal endothelial (ICE) syndrome, characterized by very few iris abnormalities but more severe corneal edema and less severe secondary glaucoma than seen in the other two ICE syndrome variants: Cogan-Reese syndrome and essential iris atrophy.
  • Hiv/aids In Bolivia Wikipedia
    The most recent example is the joint signing in February 2007 of an agreement to implement the Adoption of Attitudes and Practices to Prevent HIV-AIDS at the Interior of the Armed Forces project by the Ministry of National Defense, the Ministry of Health and Sports, the Commander-In-Chief of the Armed Forces, and UNAIDS. [1] Bolivia has been able to mobilise support from the international community, and a large proportion of its funding comes from external sources. ... This article incorporates text from this source, which is in the public domain . v t e HIV/AIDS in South America Sovereign states Argentina Bolivia Brazil Chile Colombia Ecuador Guyana Paraguay Peru Suriname Uruguay Venezuela Dependencies and other territories Falkland Islands French Guiana South Georgia and the South Sandwich Islands v t e HIV / AIDS topics HIV/AIDS HIV HIV Lentivirus structure and genome subtypes CDC classification disease progression rates HIV/AIDS diagnosis management pathophysiology prevention research vaccination PrEP WHO disease staging system for HIV infection and disease Children Teens / Adults Countries by AIDS prevalence rate Conditions Signs and symptoms AIDS-defining clinical condition Diffuse infiltrative lymphocytosis syndrome Lipodystrophy Nephropathy Neurocognitive disorders Pruritus Superinfection Tuberculosis co-infection HIV Drug Resistance Database Innate resistance to HIV Serostatus HIV-positive people Nutrition Pregnancy History History Epidemiology Multiple sex partners Timeline AIDS Museum Timothy Ray Brown Women and HIV/AIDS Social AIDS orphan Catholic Church and HIV/AIDS Circumcision and HIV Criminal transmission Discrimination against people Economic impact Cost of treatment HIV-affected community HIV/AIDS activism HIV/AIDS denialism Red ribbon Safe sex Sex education List of HIV-positive people People With AIDS Self-Empowerment Movement HIV/AIDS in the porn industry Culture Discredited HIV/AIDS origins theories International AIDS Conference International AIDS Society Joint United Nations Programme on HIV/AIDS (UNAIDS) Media portrayal of HIV/AIDS Misconceptions about HIV/AIDS President's Emergency Plan for AIDS Relief (PEPFAR) The SING Campaign Solidays Treatment Action Campaign World AIDS Day YAA/Youthforce "Free Me" Larry Kramer Gay Men's Health Crisis ACT UP Silence=Death Project HIV/AIDS pandemic by region / country Africa Angola Benin Botswana Democratic Republic of the Congo Egypt Eswatini Ethiopia Ghana Guinea Côte d'Ivoire (Ivory Coast) Kenya Lesotho Madagascar Malawi Mali Mozambique Namibia Niger Nigeria Rwanda Senegal Tanzania South Africa Uganda Zambia Zimbabwe North America Canada Mexico El Salvador Guatemala Honduras Nicaragua United States New York City Caribbean Haiti Jamaica Dominican Republic South America Bolivia Brazil Colombia Guyana Peru Asia Afghanistan Armenia Azerbaijan Bahrain Bangladesh Bhutan Cambodia China (PRC) ( Yunnan ) East Timor India Indonesia Iran Iraq Japan Jordan North Korea Laos Malaysia Myanmar (Burma) Nepal Pakistan Philippines Saudi Arabia Sri Lanka Taiwan (ROC) Thailand United Arab Emirates Turkey Vietnam Europe United Kingdom Russia Ukraine Oceania Australia New Zealand Papua New Guinea List of countries by HIV/AIDS adult prevalence rate List of HIV/AIDS cases and deaths registered by region
  • Upington Disease OMIM
    INHERITANCE - Autosomal dominant SKELETAL - Enchondromata (cartilaginous tumor growing from interior of bone) - Ecchondromata (cartilaginous tumor projecting under periosteum) - Arthralgias (hips, knees) Pelvis - Premature closure of the capital femoral epiphyses - Widened femoral necks - Flattened femoral heads MISCELLANEOUS - Onset at age 5 years - Majority of cases have bilateral involvement ▲ Close
    • Upington Disease Orphanet
      A rare primary bone dysplasia characterized by Perthes-like pelvic anomalies (premature closure of the capital femoral epiphyses and widened femoral necks with flattened femoral heads), arthralgias of hips and knees, and occurrence of enchondromata and ecchondromata. There have been no further descriptions in the literature since 1971.
    • Upington Disease Wikipedia
      You can help by adding to it . ( August 2017 ) Eponym [ edit ] The name Upington refers to the city in the Northern Cape Province , South Africa from where the family originates. [1] References [ edit ] ^ a b Online Mendelian Inheritance in Man (OMIM): 191520 ^ "Upington disease | Disease | Living With | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program" . rarediseases.info.nih.gov .
  • Desmosis Wikipedia
    . : “Pathology of Chronic Constipation in Pediatric and Adult Coloproctology“, Karger 2005 ^ Meier-Ruge WA. (1998). "Desmosis of the colon: a working hypothesis of primary chronic constipation". Eur J Pediatr Surg.8; 299-303 ^ Meier-Ruge WA, Bruder E. (2007). "The morphological characteristics of aplastic and atrophic desmosis of the intestine". Pathologe 28: 149-54 ^ Meier-Ruge WA, Bruder E. (2005). "Atrophic desmosis as secondary connective tissue atrophy in muscularis propria".
  • Prepapillary Vascular Loops OMIM
    Lambert et al. (1983) reported a family in which a 62-year-old black man had prepapillary vascular loop on the right; his 31-year-old asymptomatic daughter had 'a superior temporal artery distribution that spiraled around the superior temporal vein in several places;' her 28-year-old brother had a right temporal artery that spiraled around its attendant vein twice before bifurcating; and her 6-year-old daughter had 2 small vascular loops at the interior nasal margin of the left optic disc.
  • Trichoodontoonychial Dysplasia With Bone Deficiency OMIM
    Although not known to be related, the parents were both born in an 'endogamous community of the interior of Brazil.' Inheritance The inheritance of ectodermal dysplasia in the family described by Pinheiro et al. (1983) appeared to be autosomal recessive.
    • Trichoodontoonychial Dysplasia Orphanet
      Trichoodontoonychial dysplasia is a rare ectodermal dysplasia syndrome characterized by severe generalized hypotrichosis, parietal alopecia, secondary anodontia resulting from enamel hypoplasia, onychodystrophy, bone deficiency in the frontoparietal region and skin manifestations (incl. nevus pigmentosus, papules, ephelides, palmoplantar keratosis, supernumerary nipples, abnormal dermatoglyphics). There have been no further descriptions in the literature since 1983.
  • Hereditary Mucoepithelial Dysplasia Wikipedia
    Hereditary mucoepithelial dysplasia Other names Urban-Schosser-Spohn syndrome, HMD Structure and location of desmosomes Gap junctions, connecting the interior of two cells Malformation of desmosomes and gap junctions are caused in this condition Specialty Dermatology Hereditary mucoepithelial dysplasia ( HMD ), or simply mucoepithelial dysplasia , [1] [2] is a rare autosomal dominant multiepithelial disorder causing systemic maldevelopment of the epithelia and mucous membranes that line the surface of tissues and structures throughout the body, particularly affecting systems affiliated with mucosa, which includes the respiratory , digestive , urinary , reproductive and immune systems . [2] [3] [4] [5] [6] The disorder is attributed to improper formation of desmosomes and gap junctions , which prevents proper cornification of the epithelial layer of the skin. [5] [7] Contents 1 Pathophysiology 2 Diagnosis 3 Treatment 4 References 5 External links Pathophysiology [ edit ] Desmosomes are extracellular protein structures responsible for cellular adhesion , whereby cells of the same type are held closely together. [8] Gap junctions are specialized channels located within the cell membrane of many animal cell types, which serve as gateways that connect the cytoplasmic interior of two adjacent cells, allowing the passage of small molecules such as ions , nucleotides , second messengers and others. [9] [10] The movement and exchange of small molecules between cells is an important part of intracellular communication processes like cell signaling . [11] Diagnosis [ edit ] This section is empty.
    DNMT1, EMD, GCY, CXCL8, IL10, ATF6
    • Mucoepithelial Dysplasia, Hereditary OMIM
      Description Hereditary mucoepithelial dysplasia (HMD) is a rare autosomal dominant genodermatosis characterized by onset in infancy of a panepithelial defect involving the oral, nasal, conjunctival, vaginal, cervical, perineal, urethral, and bladder mucosa. Patients develop cataracts, blindness, nonscarring alopecia, perineal psoriasiform lesions, and follicular keratoses (Witkop et al., 1982). Although 1 family was reported to have progressive severe interstitial lung disease (Witkop et al., 1979), this feature has not been reported in other families and is not considered a criterion for diagnosis (review by Boralevi et al., 2005). Clinical Features Witkop et al. (1979) described a 4-generation kindred with a disorder termed hereditary mucoepithelial dysplasia, characterized by flat red lesions affecting the periorificial mucosa and by follicular keratosis of the skin. Affected individuals had severe photophobia and nystagmus in infancy followed by keratitis, pannus, and cataracts in childhood.
    • Hereditary Mucoepithelial Dysplasia Orphanet
      A rare, genetic, immune deficiency with skin involvement characterized by clinical triad of non-scarring alopecia affecting mainly the scalp, well-demarcated mucosal erythema and psoriasiform erythematous intertriginous plaques. Follicular keratosis, keratoconjuctivitis, cataracts, angular cheilitis, fissured tongue, and recurrent infections are additional clinical features. Histopathology of mucosal lesions show characteristic findings of dyskeratotic keratinocytes, vacuolated basal cells, lack of epithelial maturation and decreased number of desmosomes.
    • Hereditary Mucoepithelial Dysplasia GARD
      Hereditary mucoepithelial dysplasia (HMD) is a very rare condition that affects the skin, hair, mucosa (areas of the body that are lined with mucus), gums (gingiva), eyes, nose and lungs. Symptoms begin in infancy and vary in severity from person to person. The most common symptoms of this condition include hair loss ( alopecia ), patchy red skin around the perineum (the area between the anus and external genitalia); and red gums. Small, skin-colored bumps ( keratosis pilaris ) and early development of cloudy lens (cataracts) are also common. Other symptoms may include eye disease that gets worse over time, lung disease and a rough, red tongue.
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