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Bubonic Plague
Wikipedia
The American journal of pathology vol. 166,5 (2005) ^ a b c d e f g h i j k l m McCormick M. "Rats, Communications, and Plague: Toward an Ecological History". ... "Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague" . Nature Communications . 9 (1): 2234. Bibcode : 2018NatCo...9.2234S . doi : 10.1038/s41467-018-04550-9 .
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Gulf War Syndrome
Wikipedia
High-powered microwaves were used to disrupt Iraqi communications, and though it is unknown whether this might have contributed to the syndrome, research has suggested that safety limits for electromagnetic radiation are too lenient. [20] The Research Advisory Committee on Gulf War Veterans' Illnesses (RAC), a VA federal advisory committee mandated by Congress in legislation enacted in 1998, [21] [22] found that pre-2005 studies suggested the veterans' illnesses are neurological and apparently are linked to exposure to neurotoxins , such as the nerve gas sarin, the anti-nerve gas drug pyridostigmine bromide , and pesticides that affect the nervous system. ... After the air war started on January 16, 1991, coalition forces were chronically exposed to low but nonlethal levels of chemical and biological agents released primarily by direct Iraqi attack via missiles , rockets , artillery , or aircraft munitions and by fallout from allied bombings of Iraqi chemical warfare munitions facilities. [37] In 1997, the US Government released an unclassified report that stated: "The US Intelligence Community (IC) has assessed that Iraq did not use chemical weapons during the Gulf war.
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Huntington Disease
Omim
Folstein et al. (1984, 1985) contrasted HD in 2 very large Maryland pedigrees: an African American family residing in a bayshore tobacco farming community and a white Lutheran family living in a farming community in the western Maryland foothills and descended from an immigrant from Germany.
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Chiari Malformation
Wikipedia
CMs can cause headaches, difficulty swallowing, vomiting, dizziness, neck pain, unsteady gait, poor hand coordination, numbness and tingling of the hands and feet, and speech problems. [3] Less often, people may experience ringing or buzzing in the ears , weakness, slow heart rhythm, or fast heart rhythm, curvature of the spine ( scoliosis ) related to spinal cord impairment, abnormal breathing, such as central sleep apnea , characterized by periods of breathing cessation during sleep, and, in severe cases, paralysis. [3] This can sometimes lead to non-communicating hydrocephalus [4] as a result of obstruction of cerebrospinal fluid (CSF) outflow. [5] The cerebrospinal fluid outflow is caused by phase difference in outflow and influx of blood in the vasculature of the brain. ... Syringomyelia, tethered cord , and hydrocephalus may also be seen. [1] [36] Abundant neurological deficits [1] 3.5 In 1894, Giuseppe Muscatello described what is believed to be the only case of an occipitocervical encephalocele with a communication to the stomach. This is an interesting historic finding; however, has not been seen nor described since then. [25] Not compatible with life.ERF, FUZ, FGFR3, SKI, POLR3A, CHD4, SON, CLIP2, ZIC1, HMGA2, BAZ1B, GTF2IRD1, TMEM94, SIK3, SALL1, LEMD3, TBL1XR1, TBL2, SETD2, DACT1, MKS1, RFWD3, FANCI, SC5D, RFC2, PORCN, PTEN, VANGL1, DNMT3A, ELN, FBN1, FGFR1, FGFR2, GNAQ, GTF2I, KMT2C, LIMK1, MECP2, NOTCH2, NOTCH3, PIK3CA, POR, PTCH1, LRP5, UCN2, PPP1R2C, AQP1, UNC50, ZRSR2, LAMC2, CSF2, CREBBP, UTS2B
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Multiple System Atrophy
Wikipedia
Speech changes mean that alternative communication may be needed, for example communication aids or word charts. [ citation needed ] Early intervention of swallowing difficulties is particularly useful to allow for discussion around tube feeding further in the disease progression. [ citation needed ] At some point in the progression of the disease, fluid and food modification may be implemented. [ citation needed ] Avoidance of postural hypotension [ edit ] One particularly serious problem, the drop in blood pressure upon standing up (with risk of fainting and thus injury from falling), often responds to fludrocortisone , a synthetic mineralocorticoid . [38] Another common drug treatment is the alpha-agonist midodrine . [39] Non-drug treatments include "head-up tilt" (elevating the head of the whole bed by about 10 degrees), salt tablets or increasing salt in the diet, generous intake of fluids, and pressure (elastic) stockings.ABCB1, OPRM1, OPRD1, CYB561, SNCA, DBH, IL12A, HEXB, COQ2, IL12RB1, IRF5, TNFSF15, TNPO3, MMEL1, POU2AF1, ELP1, AAAS, CHCHD2, SPIB, ATP7A, CYP11B2, CAV1, JAG1, SELENBP1, SHBG, CCHCR1, ACE, TTR, AGT, REN, NEDD4L, ADRB2, ARHGEF5, PWAR1, IS1, YWHAE, TP63, ASXL1, ACE2, NR1I2, TIMELESS, TET2, DOCK11, DKK1, SF3B1, LRRK2, HAVCR1, PRRT2, PPP1R14A, SLC52A2, ADRB1, PRKCA, TPO, SOD2, AGTR1, ALB, AR, CASP8, CRP, CYP17A1, EBF1, MARK2, F2R, FAP, GNAS, GNB3, CXCL1, IL1B, MMP7, NOS1, NPPA, NPPB, NPR3, OLR1, PAFAH1B1, PRKN, PGF, PRKCB, PRL, CCL2, SLC6A3, MCIDAS
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Nonketotic Hyperglycinemia
Gene_reviews
Biallelic pathogenic variants in GCSH (encoding the GCS H-protein component) have been proposed as a cause of NKH in two individuals [C Acquaviva, P Rodríguez-Pomb, personal communications]; however, this remains unconfirmed. ... Individuals in this category learn to walk and communicate with some speech but mostly sign language.
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Transmissible Spongiform Encephalopathy
Wikipedia
It may also be involved in protecting brain cells and helping them communicate. 24 [ citation needed ] Point- Mutations in this gene cause cells to produce an abnormal form of the prion protein, known as PrP Sc . ... Biochemical and Biophysical Research Communications . 308 (3): 660–7. doi : 10.1016/S0006-291X(03)01459-1 .PRNP, CX3CL1, CX3CR1, SNCA, CLU, MARK4, LINC02210-CRHR1, TOMM40, CARD14, MS4A4A, CHN2, ABCB6, ABCA7, RPS4XP2, PRDX2, PPP1R12B, CCDC62, CD2AP, SLC2A13, C4BPA, BST1, LINC02210, MS4A4E, BLOC1S3, C9orf72, ANK3, EPHA1-AS1, GH1, MAPT, CSF2, LAMC2, PRKN, APP, APOE, SOD1, HECTD2, CBLL2, MUL1, PDIK1L, NEFL, LINC01672, IGFALS, HSPA4, TNF, SPRN, MGRN1, GSS, AHSP, IL6, IL1B, IAPP, SERPINA3, GPI, ADAM10, FXN, SMUG1, MMRN1, SARM1, CHN1, SIRT3, CABIN1, CFH, CHI3L1, PRND, SEC61A1, CFL1, CD44, GDE1, TPPP, STMN2, XAF1, YWHAQ, STIP1, HPSE, CHRM1, PLK3, RABEPK, EDIL3, DNM1L, CR1, CST7, BAG6, CR2, EGLN1, FKBP10, CD40LG, CXCR5, ACHE, SNORD3A, ACTB, MIR342, MIR21, AKT1, PLCXD3, APCS, NEGR1, CALHM1, AQP1, AQP4, BRCA2, THY1, LRFN5, CPNE8, C5AR1, SIRPA, NLRP3, CASP1, CD9, CD14, AKT1S1, MINDY4, CD28, CD40, TLR2, TGFB2, TGFB3, HIF1A, P4HB, OGG1, NGF, NFKB1, NFE2L2, EGFR, ERBB2, MTR, MKLN1, MFGE8, MBP, FANCD2, LGALS1, LAMA3, LAG3, KARS1, IRF3, CXCL8, GFAP, GLS, IL1A, IFNAR1, IFN1@, PDIA3, HSPD1, HSPA5, GSN, DECR1, PDCD1, PDK1, RARB, CRYAB, ADAM17, HSPA13, SP1, SOD2, CSF1R, SNCG, CTSD, SNCB, SLC1A3, CYBB, RYR2, PVALB, PIK3CA, PTGS2, PSEN1, RELN, DAB1, PRKAB1, PRKAA2, PRKAA1, PPIA, PIN1, PIK3CG, PIK3CD, ABCA1, PIK3CB
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Guillain–barré Syndrome
Wikipedia
Occupational therapy aims to improve everyday function with domestic and community tasks as well as driving and work. Home modifications, gait aids, orthotics and splints may be provided. [37] Speech-language pathology input may be required in those with speech and swallowing problems, as well as to support communication in those who require ongoing breathing support (often through a tracheostomy ).PMP22, CD86, AIRE, TNF, IL17A, CSF2, LAMC2, CD1E, ALB, CD1A, HLA-DQB1, IL1B, CD1C, TLR4, IL10, CD1B, ICAM1, IL23A, ISG20, FCGR2A, CRP, IL4, IL2RA, IL17D, HLA-DRB1, IL6, MAPK1, NFASC, GFAP, ITGAM, COX2, MYDGF, PTGS2, FCGR3A, APOE, IL27, FAS, MTCO2P12, CNTNAP1, YY1, YWHAZ, CXCR4, AIMP2, RETN, SELENBP1, TNFRSF1B, MIR155, GRAP2, GLDN, NOD1, VIM, MIR642B, SIGLEC14, AHSA1, OCLN, TLR2, TH, TGFB1, STAT3, SPP1, SMPD2, CXCL6, CCL2, PTPN11, MIF-AS1, IVNS1ABP, CSGALNACT1, POLDIP2, SMPD3, NS2, IL21, ISYNA1, FOXP3, IL22, ICOS, DLL1, ERVK-6, SIGLEC9, ST6GALNAC4, PTGS1, RNF19A, TUBGCP2, NOD2, SUMF2, FTSJ1, IL33, CADM1, FCRL3, FTSJ3, RBM45, HT, CABIN1, PLB1, YWHAQ, SIGLEC7, NOS2, PSMB6, F2R, HMGB1, HLA-DQB2, HLA-DQA1, HLA-DOA, CXCL2, CXCL1, NR3C1, GOLGA4, GNAO1, GLO1, GJB1, GALE, FOLH1, FCGR3B, ESR1, HPRT1, EPHB2, ENO2, CST3, MAPK14, CRK, COX8A, CNTN1, CDC42, CD59, CD80, CD14, CACNA1A, SERPING1, FASLG, HP, HSPA4, MAP2K7, MMP2, MAPK8, PRKD1, POMC, PLA2G1B, PKD1, PGF, PDCD1, NPPB, NPY, NOS3, NEFL, COX1, MRC1, MMP9, NR3C2, HSPD1, MIF, MBL2, LEP, ITGB2, ITGAL, IRF6, INSRR, CXCL10, IL18, IL12B, IL12A, IL2, IGHG3, IFNG, ERVK-32
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Spinocerebellar Ataxia Type 1
Gene_reviews
Treatment of manifestations: Canes and walkers to help prevent falls; modification of the home with grab bars, raised toilet seats, and ramps for motorized chairs; speech therapy and communication devices for dysarthria; weighted eating utensils and dressing hooks to help maintain independence. ... Modification of the home with such conveniences as grab bars, raised toilet seats, and ramps to accommodate motorized chairs may be necessary. Speech therapy and communication devices such as writing pads and computer-based devices may benefit those with dysarthria.ATXN1, ATXN2, CACNA1A, ATXN1L, GRM1, RBM17, ATXN7, SPTBN2, CIC, PRKCG, TRPC3, CACNA1G, RUBCN, STUB1, NOP56, AFG3L2, WWOX, TDP2, MME, ANO10, CWF19L1, SNX14, SCYL1, ELOVL5, UBA5, TTBK2, VWA3B, SYT14, TGM6, PPP2R2B, CCDC88C, GFI1, FOXC1, GRID2, LY6E, ATXN3, CAT, ANP32A, AR, PDYN, S100B, GLO1, VEGFA, PQBP1, FXN, ATN1, HLA-A, DCTN4, PMPCA, MTOR, NUP62, NLK, ESRRB, FRAXA, SYNE1, ETV6, EPHA3, PAG1, C21orf62, PCBP4, FRAXE, EIF4E, EDN1, DNMT1, PCP2, CSF1R, CREBBP, TCTE1, CASP3, BDNF, MIR144, KHDRBS1, HSF1, KAT5, ATOX1, IVL, HMGB1, PAK1, PML, HLA-DPB1, PTPA, OPN1LW, RPA1, HTT, GTF2H1, SLC1A3, SNRNP70, TGM2, FUS, TNF, TTR, TXNRD1, UBE2E1, UBE3A, COIL, HSD17B6, HDAC3, SQSTM1, HSP90AA1, PUM1, GAPDH, RPS6KA5
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Pseudomembranous Colitis
Mayo_clinic
More and more often, C. difficile is being reported in people with no known risk factors, including people with no recent health care contact or use of antibiotics. This is called community-acquired C. difficile . Emergence of a new strain An aggressive strain of C. difficile has emerged that produces far more toxins than other strains do.
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Body Dysmorphic Disorder
Mayo_clinic
Contact a minister, spiritual leader or someone else in your faith community. Causes It's not known specifically what causes body dysmorphic disorder.
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Frem1 Autosomal Recessive Disorders
Gene_reviews
Based on the number of individuals identified to date in the aboriginal Oji-Cree community of the Island Lake region of northern Manitoba, Canada, which had a population of 4,685 in 1996 and 2,020 in 2001 [First Nation Profiles 2004], the incidence of MOTA syndrome in that population is estimated at 2:1,000-6:1,000 births; however, this may be an underestimate in this population, as a few presumably affected individuals have also been identified through family histories of affected individuals, and some milder cases may not have come to medical attention.
- Post-Polio Syndrome Mayo_clinic
- Pallister-Killian Syndrome Omim
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- Fucosidosis Omim
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Atrioventricular Block
Wikipedia
On ECG, the PR interval is unchanged from beat to beat, but there is a sudden failure to conduct the signal to the ventricles, and a resulting random skipped beat. [4] The risks and possible effects of Mobitz II are much more severe than Mobitz I in that it can lead to severe heart attack. [9] [10] Third-degree Atrioventricular Block [ edit ] Third-degree AV block occurs when the signal between the atria and ventricles is completely blocked, and there is no communication between the two. None of the signals from the upper chambers make it to the lower chambers.LMNA, GNAI2, SCN5A, KCNH2, DES, KCNQ1, PRKAG2, TRPM4, TTN, ACADVL, MTM1, KCNJ5, MMP2, AGXT, SCN4B, MYBPC3, TTR, BVES, SYNE2, SYNE1, TMEM43, KCNJ2, MMP14, CACNA2D1, GLA, GPX4, FHL1, EMD, SLC25A20, NKX2-5, CALR, TDP2, ARSD, TBX5, TRIM21, ARFGEF1, GJC1, TOPORS, ITGAM, SDS, PKD2L1, CACNA1C, SMUG1, RHOA, APRT, ARID2, HCN4, TBX6, CALCR, TBX3, SSB, SLC6A8, SCN10A, CAV1, PKD2, PITX2, CUX1, FLT4, MFAP1, GATA4, KRT5, GNB2, MIR19B1
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Allergies In Children
Wikipedia
PMID 11427385 . v t e Diseases of the respiratory system Upper RT (including URTIs , common cold ) Head sinuses Sinusitis nose Rhinitis Vasomotor rhinitis Atrophic rhinitis Hay fever Nasal polyp Rhinorrhea nasal septum Nasal septum deviation Nasal septum perforation Nasal septal hematoma tonsil Tonsillitis Adenoid hypertrophy Peritonsillar abscess Neck pharynx Pharyngitis Strep throat Laryngopharyngeal reflux (LPR) Retropharyngeal abscess larynx Croup Laryngomalacia Laryngeal cyst Laryngitis Laryngopharyngeal reflux (LPR) Laryngospasm vocal cords Laryngopharyngeal reflux (LPR) Vocal fold nodule Vocal fold paresis Vocal cord dysfunction epiglottis Epiglottitis trachea Tracheitis Laryngotracheal stenosis Lower RT / lung disease (including LRTIs ) Bronchial / obstructive acute Acute bronchitis chronic COPD Chronic bronchitis Acute exacerbation of COPD ) Asthma ( Status asthmaticus Aspirin-induced Exercise-induced Bronchiectasis Cystic fibrosis unspecified Bronchitis Bronchiolitis Bronchiolitis obliterans Diffuse panbronchiolitis Interstitial / restrictive ( fibrosis ) External agents/ occupational lung disease Pneumoconiosis Aluminosis Asbestosis Baritosis Bauxite fibrosis Berylliosis Caplan's syndrome Chalicosis Coalworker's pneumoconiosis Siderosis Silicosis Talcosis Byssinosis Hypersensitivity pneumonitis Bagassosis Bird fancier's lung Farmer's lung Lycoperdonosis Other ARDS Combined pulmonary fibrosis and emphysema Pulmonary edema Löffler's syndrome / Eosinophilic pneumonia Respiratory hypersensitivity Allergic bronchopulmonary aspergillosis Hamman-Rich syndrome Idiopathic pulmonary fibrosis Sarcoidosis Vaping-associated pulmonary injury Obstructive / Restrictive Pneumonia / pneumonitis By pathogen Viral Bacterial Pneumococcal Klebsiella Atypical bacterial Mycoplasma Legionnaires' disease Chlamydiae Fungal Pneumocystis Parasitic noninfectious Chemical / Mendelson's syndrome Aspiration / Lipid By vector/route Community-acquired Healthcare-associated Hospital-acquired By distribution Broncho- Lobar IIP UIP DIP BOOP-COP NSIP RB Other Atelectasis circulatory Pulmonary hypertension Pulmonary embolism Lung abscess Pleural cavity / mediastinum Pleural disease Pleuritis/pleurisy Pneumothorax / Hemopneumothorax Pleural effusion Hemothorax Hydrothorax Chylothorax Empyema/pyothorax Malignant Fibrothorax Mediastinal disease Mediastinitis Mediastinal emphysema Other/general Respiratory failure Influenza Common cold SARS Coronavirus disease 2019 Idiopathic pulmonary haemosiderosis Pulmonary alveolar proteinosis v t e Respiratory physiology Respiration breath inhalation exhalation obligate nasal breathing respiratory rate respirometer pulmonary surfactant compliance elastic recoil hysteresivity airway resistance bronchial hyperresponsiveness constriction dilatation mechanical ventilation Control pons pneumotaxic center apneustic center medulla dorsal respiratory group ventral respiratory group chemoreceptors central peripheral pulmonary stretch receptors Hering–Breuer reflex Lung volumes VC FRC Vt dead space CC PEF calculations respiratory minute volume FEV1/FVC ratio Lung function tests spirometry body plethysmography peak flow meter nitrogen washout Circulation pulmonary circulation hypoxic pulmonary vasoconstriction pulmonary shunt Interactions ventilation (V) Perfusion (Q) Ventilation/perfusion ratio V/Q scan zones of the lung gas exchange pulmonary gas pressures alveolar gas equation alveolar–arterial gradient hemoglobin oxygen–hemoglobin dissociation curve ( Oxygen saturation 2,3-BPG Bohr effect Haldane effect ) carbonic anhydrase ( chloride shift ) oxyhemoglobin respiratory quotient arterial blood gas diffusion capacity ( DLCO ) Insufficiency high altitude death zone oxygen toxicity hypoxia v t e Allergic conditions Respiratory system Allergic rhinitis (hay fever) Asthma Hypersensitivity pneumonitis Eosinophilic pneumonia Eosinophilic granulomatosis with polyangiitis Allergic bronchopulmonary aspergillosis Farmer's lung Laboratory animal allergy Skin Angioedema Urticaria Atopic dermatitis Allergic contact dermatitis Hypersensitivity vasculitis Blood and immune system Serum sickness Circulatory system Anaphylaxis Digestive system Coeliac disease Eosinophilic gastroenteritis Eosinophilic esophagitis Food allergy Egg allergy Milk intolerance Nervous system Eosinophilic meningitis Genitourinary system Acute interstitial nephritis Other conditions Drug allergy Allergic conjunctivitis Latex allergy v t e Hypersensitivity and autoimmune diseases Type I / allergy / atopy ( IgE ) Foreign Atopic eczema Allergic urticaria Allergic rhinitis (Hay fever) Allergic asthma Anaphylaxis Food allergy common allergies include: Milk Egg Peanut Tree nut Seafood Soy Wheat Penicillin allergy Autoimmune Eosinophilic esophagitis Type II / ADCC IgM IgG Foreign Hemolytic disease of the newborn Autoimmune Cytotoxic Autoimmune hemolytic anemia Immune thrombocytopenic purpura Bullous pemphigoid Pemphigus vulgaris Rheumatic fever Goodpasture syndrome Guillain–Barré syndrome " Type V "/ receptor Graves' disease Myasthenia gravis Pernicious anemia Type III ( Immune complex ) Foreign Henoch–Schönlein purpura Hypersensitivity vasculitis Reactive arthritis Farmer's lung Post-streptococcal glomerulonephritis Serum sickness Arthus reaction Autoimmune Systemic lupus erythematosus Subacute bacterial endocarditis Rheumatoid arthritis Type IV / cell-mediated ( T cells ) Foreign Allergic contact dermatitis Mantoux test Autoimmune Diabetes mellitus type 1 Hashimoto's thyroiditis Multiple sclerosis Coeliac disease Giant-cell arteritis Postorgasmic illness syndrome Reactive arthritis GVHD Transfusion-associated graft versus host disease Unknown/ multiple Foreign Hypersensitivity pneumonitis Allergic bronchopulmonary aspergillosis Transplant rejection Latex allergy (I+IV) Autoimmune Sjögren syndrome Autoimmune hepatitis Autoimmune polyendocrine syndrome APS1 APS2 Autoimmune adrenalitis Systemic autoimmune disease
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