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Pashayan Syndrome
Wikipedia
.; Verloes, A.; Fourneau, C.; Gillerot, Y. (28 June 2008). "Mental retardation with blepharo-naso-facial abnormalities and hand malformations: a new syndrome?". ... PMID 1633641 . ^ Zampino, Giuseppe; Colosimo, Cesare; Balducci, Francesca; Mariotti, Paolo; Serra, Fabrizio; Scarano, Gioacchino; Mastroiacovo, Pierpaolo (28 June 2008). "Cerebro-facio-articular syndrome of Van Maldergem: confirmation of a new MR/MCA syndrome".
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Parapharyngeal Abscess
Wikipedia
"Radiology Reference Article: Parapharyngeal abscess" . Radiopaedia.org . Retrieved 28 February 2017 . ^ a b c Sasaki, Clarence T. ... Merck Sharp & Dohme Corp . Retrieved 28 February 2017 . ^ Dhingra, PL (2014).
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Lymphoma In Animals
Wikipedia
Archived from the original (PDF) on 2007-09-29 . Retrieved 2007-01-28 . ^ a b c Hoskins, Johnny D. (May 2006). ... The Merck Veterinary Manual . 2006 . Retrieved 2007-01-28 . ^ Bhang D, Choi U, Kim M, Choi E, Kang M, Hwang C, Kim D, Youn H, Lee C (2006). ... The Merck Veterinary Manual . 2006 . Retrieved 2007-01-28 . ^ Ettinger, Stephen J.; Feldman, Edward C. (1995). ... The Merck Veterinary Manual . 2006 . Retrieved 2007-01-28 . ^ Richter, Keith P. (2006). "Feline gastrointestinal lymphoma" (PDF) . ... Archived from the original (PDF) on 2007-09-29 . Retrieved 2007-01-28 . ^ a b Matz, Michael E. (January 2007).
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Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
Omim
His fingernails showed proximal leukonychia, whereas his toenails showed mild onycholysis, with slight elevation of the nail plates by a small amount of yellowish subungual debris. The proband's 28-year-old brother was similarly affected. ... Lin et al. (2015) reported 2 unrelated women with peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads; the authors proposed the acronym PLACK for the syndrome. The first patient was a 28-year-old Chinese woman who had infantile onset of trauma-induced blistering of the extremities, which worsened in the summer; she also had asymptomatic skin peeling with underlying erythema in the winter. ... Other features included leukonychia, leukokeratosis, angular cheilitis, papules on the extensor surfaces of fingers and toes, and punctate palmar keratoses with plantar keratoderma. Molecular Genetics In a 28-year-old Chinese woman with PLACK, who was negative for mutation in the CDSN (602593), TGM5 (603805), CHST8 (610190), and CSTA (184600) genes, Lin et al. (2015) performed exome sequencing and identified homozygosity for a 1-bp duplication in the CAST gene (114090.0001).
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Ankylosis
Wikipedia
June 2016. Archived from the original on 28 September 2016 . Retrieved 28 September 2016 . ^ Berenbaum F (2013). ... "Noma: report of a case resulting in bony ankylosis of the maxilla and mandible". Dentomaxillofacial Radiology . 28 (6): 378–382. doi : 10.1038/sj.dmfr.4600475 .
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Carotid-Cavernous Fistula
Wikipedia
Indirect CCF may be treated by occlusion of the affected cavernous sinus with coils, liquid agents or a combination of both. [2] [3] [4] References [ edit ] ^ a b Thinda, S; Melson, MR; Kuchtey, RW (Jul 28, 2012). "Worsening angle closure glaucoma and choroidal detachments subsequent to closure of a carotid cavernous fistula" . BMC Ophthalmology . 12 : 28. doi : 10.1186/1471-2415-12-28 . PMC 3412712 .
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Precancerous Condition
Wikipedia
National Cancer Institute . 2011-02-02 . Retrieved 2018-03-28 . ^ "Precancerous conditions of the colon or rectum" . ... Archived from the original on 2017-07-10 . Retrieved 2018-03-28 . ^ a b Roberts JR, Siekas LL, Kaz AM (February 2017). ... PMID 28255426 . ^ "Actinic keratosis - Symptoms and causes" . Mayo Clinic . Retrieved 2018-03-28 . ^ a b Willimsky G, Czéh M, Loddenkemper C, Gellermann J, Schmidt K, Wust P, Stein H, Blankenstein T (July 2008). ... . www.cancer.org . Retrieved 2018-03-28 . ^ a b Arya M, Kalsi J, Kelly J, Muneer A (March 2013). ... S2CID 33771829 . ^ "Bladder Cancer Staging | Bladder Cancer Stages" . www.cancer.org . Retrieved 2018-03-28 . External links [ edit ] Classification D MeSH : D011230 Look up premalignant or precancerous in Wiktionary, the free dictionary. v t e Overview of tumors , cancer and oncology Conditions Benign tumors Hyperplasia Cyst Pseudocyst Hamartoma Malignant progression Dysplasia Carcinoma in situ Cancer Metastasis Primary tumor Sentinel lymph node Topography Head and neck ( oral , nasopharyngeal ) Digestive system Respiratory system Bone Skin Blood Urogenital Nervous system Endocrine system Histology Carcinoma Sarcoma Blastoma Papilloma Adenoma Other Precancerous condition Paraneoplastic syndrome Staging / grading TNM Ann Arbor Prostate cancer staging Gleason grading system Dukes classification Carcinogenesis Cancer cell Carcinogen Tumor suppressor genes / oncogenes Clonally transmissible cancer Oncovirus Carcinogenic bacteria Misc.PTGS2, CDKN2A, HRAS, VEGFA, CCND1, AKT1, MUC1, MGMT, STAT3, CDH1, IL6, CAT, PRKAA1, PSCA, MPO, ARG1, ABL1, MDM2, IGF2, EGF, MIR196B, FOXM1, ALDH4A1, GSTO1, IFT88, NR1I3, TSC2, TNK2, TRIO, YIF1A, TPM4, TP53, STAT5A, PRKG1, SOD2, KRT8, GJB1, GSTA4, GSTP1, HADH, IGFBP1, IRS1, PEBP1, SIX3, PRDX1, PHB, PIM1, MAPK8, MAPK9, SERPINB3, UQCR11, COG4, SULF1, WSCD1, MIR125A, MIR145, MIR200B, MIR211, MIR212, MIR26B, MIR30A, MIR30D, MIR98, MIR99B, MIR324, MIR331, MIR338, MIR340, MIR409, MIR483, MIR92B, MIR652, MAGED4, MIRLET7D, MIRLET7B, ZBTB8OS, CCDC134, EXOSC2, ZBTB20, NOP16, ERGIC3, TRIT1, DPP10, PBLD, DDX54, PSD2, HIGD2A, AOPEP, COL23A1, SLC52A3, TMEM132D, SOCS4, SIRPA, TTLL9, PRICKLE2, FTH1, MAP2K7, CHN2, CPS1, EFNB2, CISH, ACTC1, ACY1, ALDH2, ANXA4, CFL1, ATP5F1B, BCAT2, CEBPA, CDX2, EIF4EBP1, MIR371A, ERBB2, H3P10, KRAS, CTNNB1, BCL2, TERT, APC, COX2, PIK3CA, MTCO2P12, ESR1, RARB, PIK3CB, NFE2L2, MYC, PIK3CD, PIK3CG, CDKN1A, PTEN, GABPA, BRCA1, GSTT1, RUNX3, SOX9, CALCA, TFF1, EGFR, TLR4, CD44, TNF, CD274, NOTCH1, RASSF1, SFRP1, CST6, SCGB3A1, PCNA, PAK1, CTNND1, MSH2, MMP3, MLH1, NRAS, SPP1, S100A8, SDC1, ST3GAL4, TGFB1, THBS1, CD24, SMAD4, ARID1A, PDLIM7, CEACAM5, PIAS3, BMI1, CDH13, OTUD4, TET2, DCN, ERCC2, IL1B, IGF1, FASN, HGF, EZH2, IL10, EDNRB, HOXA9, HTC2, GATA4, IL1RN, H2AX, GSTM1, STMN1, FHIT, TLR9, GATA1, IL23A, CDC25B, NOL7, ERVW-1, TMOD4, LEF1, FOXP3, DGCR8, G0S2, ASAP1, LEP, UGT1A9, GAS6, SCPEP1, CREBZF, CTDSP1, CD34, AS3MT, SLURP1, AKR1B10, SLC12A9, LAPTM4B, IMP3, MTPAP, PIWIL2, ESRP1, UHRF1, GALR1, CD38, MCAT, MCTS1, RIPK3, MYT1L, RAB3GAP1, MGLL, TUSC2, PDAP1, CXCL1, SDS, FUT1, CDX1, CKAP4, PAPOLA, MRPS30, YAP1, WFDC2, EPOR, CDK2, SYNE1, CDH17, DICER1, CD2AP, LDOC1, SMPX, GATA6, CDC25C, INTS6, AGO1, PELP1, AGO2, PDCD4, HPGDS, RBMX, TSKS, CAV1, NOD2, MIR29B1, ANXA5, FGFR1, MIR34C, MIR31, FAS, FASLG, MIR27B, ALOX15B, RHOA, MIR222, ATF3, ATM, FGFR3, MIR186, FGF2, AKT2, ATR, ETV6, LOC110806263, ESR2, COMMD3-BMI1, MICA, ETS1, ACP3, MECOM, NR0B1, MIR421, ZG16, POU5F1P4, POU5F1P3, PARP1, AGTR1, MIR183, KIF1A, SOX17, CA9, KLF9, VASN, KLF5, SFXN1, HTRA3, FOSL2, GAST, CKS1BP7, RSPO3, ACSS1, CASP3, FBXO11, RABEP2, RUNX1, BRAF, FOS, MIR10A, GKN2, BARD1, STING1, FHL2, TAS2R64P, ENDOV, MAPK15, ERBB3, PRIMA1, ASXL1, DDX53, BMP5, DST, ASPRV1, IL23R, EIF4E, AKAP12, PDZK1IP1, EPHA2, VCAN, PTPA, CTSA, POU5F1, POLR2G, PMP22, PLAU, PKM, IGFBP5, RBPJ, CST3, IL2, ABCB1, PGC, PDCD1, PRKAA2, PRKDC, CSK, PSMD10, RB1, IGF2R, PVT1, CLDN4, PTGS1, PTGDS, PSG2, CSHL1, PSG1, PSEN2, KLK6, PRL, ACAT1, IGFBP2, DNMT3B, REG3A, CXCL8, MMP2, MPZ, CYP1B1, MMP12, MMP11, MMP7, KRT14, MMP1, SARDH, RPSA, DAB2, MET, MAT1A, LCN2, SMAD3, MRC1, MST1R, IL11, DNMT1, OGG1, IL18, NOTCH3, EIF3E, NME1, NFKBIA, MYCN, COX1, ITGB1, MYBL2, MUC5AC, MUC2, CTSL, KIT, RBL2, RET, RPE65, HIC1, WNT2, WNT1, CHI3L1, UVRAG, UBE2I, TXN, CKB, CHEK1, TRAF3, RBMXP1, TP53BP1, CKS1B, TNFAIP3, TLX1, SEM1, CEACAM7, HPGD, CLDN1, G3BP2, KLK4, LOXL2, HDAC1, HDC, NOLC1, BTRC, PPM1D, CCNA1, ASAP2, HYAL2, CEACAM3, TP63, IFITM1, TLR2, THBD, RRBP1, CCL18, SLC16A1, COL11A2, IDH1, ST6GAL1, IDH2, SDHB, CP, SNAI1, SAI1, S100A9, IGF1R, S100A7, S100A6, S100A4, SLC22A3, COL2A1, TGFB3, TARBP2, HPR, TGFA, EYA4, HSPA1A, HSPA1B, TCF4, SYCP1, SORD, AURKA, CMA1, CCR7, HSPA2, SPINK1, SOX2, TFF2
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Hypersexual Disorder
Wikipedia
. ^ "American Psychiatric Association DSM-5 Development Page for Hypersexual Disorder" . Dsm5.com . Retrieved 28 August 2017 . ^ "DSM-5 Development Page for Sexual Dysfunctions" . Dsm5.org . Retrieved 28 August 2017 . ^ Kafka, M. P. (2010). ... Archives of Sexual Behavior, 39, 377–400. ^ "Psychiatry's bible: Autism, binge-eating updates proposed for 'DSM' - USATODAY.com" . Usatoday.com . Retrieved 28 August 2017 . ^ "Archived copy" . ... Health.usnews.com . Retrieved 2017-08-28 . ^ Reid, Rory C.; Carpenter, Bruce N.; Hook, Joshua N.; Garos, Sheila; Manning, Jill C.; Gilliland, Randy; Cooper, Erin B.; McKittrick, Heather; Davtian, Margarit; Fong, Timothy (1 November 2012).
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Vaccine Shedding
Wikipedia
The route of infection was through contact with faeces , and some vaccines, like the viruses they prevent, are shed in stool for up to 28 days. [8] Normal hygiene is sufficient to prevent infection [9] but immunocompromised individuals need to be especially diligent. [10] Other attenuated vaccines show no significant shedding, inadvertent infection is rare [11] (for example, there are 11 cases of chickenpox which may have been transmitted by vaccinated individuals out of approximately 50 million doses), [12] and only a single case of transmission of influenza virus has been documented, and that person remained asymptomatic . [13] The attenuated virus from vaccines is much weaker and less likely to infect than the wild virus. [14] Regulatory authorities in the USA and EU recommend that shedding data should be collected both during the development phase of a new product and during clinical trials . A full report on shedding must subsequently be included in the Biologics license application . [15] [16] A study of 345 participants aged 5–49 years who received the live influenza virus vaccine LAIV3, and for whom shedding was assessed by viral culture of nasal swabs (daily for days 1–7 post vaccination, every other day for days 9 through 25, and on day 28) indicated that 30% had detectable virus in nasal secretions obtained by nasal swabbing. ... Retrieved 2018-04-29 . ^ "Who Should not Get Vaccinated" . www.cdc.gov . 2018-03-28 . Retrieved 2018-04-29 . ^ "Ask the Experts about Rotavirus Vaccines – CDC experts answer Q&As" . www.immunize.org . ... The Journal of Infectious Diseases . 181 (2): 725–28. doi : 10.1086/315246 . ISSN 0022-1899 .
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Central Nervous System Tumor
Wikipedia
Retrieved 2019-06-28 . ^ "Signs and Symptoms of Adult Brain and Spinal Cord Tumors" . www.cancer.org . Retrieved 2019-06-28 . ^ "Brain tumor - Diagnosis and treatment - Mayo Clinic" . www.mayoclinic.org . Retrieved 2019-06-28 . ^ "Übersicht- Deutsches Kinderkrebsregister" . www.kinderkrebsregister.de . ... Retrieved 2019-06-28 . ^ "Risk Factors for Brain and Spinal Cord Tumors" . www.cancer.org . Retrieved 2019-06-28 . ^ "Signs and Symptoms of Adult Brain and Spinal Cord Tumors" . www.cancer.org .TP53, APC, BAP1, MLH1, SMARCB1, EGFR, EWSR1, EPHB2, SMARCA4, RTEL1, STN1, LRIG1, ACOT11, ETFA, MAML2, SLC25A24, GOLGA3, LRRC31, POLR3B, KIF26B, SLC16A8, LMF1, SMYD3, IDH1, RHBDF1, RAVER2, HEATR3, MDM4, CCDC26, C2orf80, RNU6-1318P, MIR4300HG, RTEL1-TNFRSF6B, TRAF5, WT1, ZBTB16, CDKN2B-AS1, BRAF, SLC35A3, AKT3, AKAP6, POLR2A, PHLDB1, VTI1A, DBT, IDH2, NF2, GFAP, MYCN, NES, BCOR, VEGFA, MAP2K7, MRC1, MYC, NKX2-1, LAMC2, MIR34A, EPO, CSF2, BCL2, MIR200A, MVP, TCL1B, MIR21, F2RL3, KAT2B, PROM1, ULK1, TYR, GSTK1, XRCC6P5, MIR367, MIA, TCL1A, C20orf181, CD24, H3C9P, VHL, COMMD3-BMI1, OLIG2, PWAR4, YAP1, GOPC, KIAA1549, NT5C3A, LIN28A, GAL, PPP1R2C, CD274, SETD2, CD276, MINDY4, PYGO2, SGSM3, AZIN2, SLCO6A1, PRAME, FOXR2, ZHX2, RASSF1, GADL1, AGR2, PARP1, SDHB, TTF1, CTNNB1, DLG3, DRD4, EPHA2, ERCC1, FAP, FGFR1, KAT2A, GLS, H3-3A, H3-3B, HGF, HRG, HSPA4, IGFBP2, IL4, DES, CDKN2A, IL10, CDKN1A, ALK, AMBP, ANXA2, APOD, APOE, AQP1, ATRX, BMI1, BRCA2, DDR1, CALCR, CALR, CAPG, CDH1, CDK4, CXCL8, MAK, TPI1, PLG, MAPK1, PTGS2, PTPRC, RAF1, ROS1, S100A4, SAI1, CCL2, ALB, SLAMF1, SLC6A8, SMO, SOX10, AURKA, TF, PML, PLAU, CD46, PIK3CG, MEN1, MGMT, CD99, MNAT1, MSH2, MT1E, COX2, MTHFR, NRAS, PAWR, PDGFRA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, MTCO2P12
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Paragangliomas 4
Omim
Vanharanta et al. (2004) reported a family in which the proband was diagnosed with metastatic renal clear cell carcinoma (RCC; 144700) at age 28 years. The patient's mother had a malignant PGL within the heart. ... Mean +/- SD tumor size was 7.8 +/- 3.7 cm. In this referral-based study, 28% presented with metastatic disease and all but one eventually developed metastases after 2.7 +/- 4.1 years. ... Examination of relatives yielded a total of 32 and 34 manifesting carriers of SDHB and SDHD mutations, respectively. Multiple tumors occurred in 28% of SDHB carriers and 74% of SDHD carriers; adrenal pheochromocytomas occurred in 28% of SDHB carriers and 53% of SDHD carriers, whereas extraadrenal pheochromocytomas were identified in 48% of SDHB carriers and 21% of SDHD carriers; head and neck paragangliomas occurred in 31% of SDHB carriers and 79% of SDHD carriers; and malignancy occurred in 34% of SDHB carriers but no SDHD carriers. ... For the index cases, there was no difference between 43 SDHB and 19 SDHD mutation carriers in the time to first diagnosis (34 vs 28 years, respectively; p = 0.3). However, when all 112 mutation carriers were included, the estimated age-related penetrance was different for SDHB versus SDHD mutation carriers (p = 0.008). ... INHERITANCE - Autosomal dominant HEAD & NECK Ears - Pulsatile tinnitus (tympanic paraganglioma) CARDIOVASCULAR Heart - Palpitations (with pheochromocytoma) - Tachycardia (with pheochromocytoma) Vascular - Hypertension (with pheochromocytoma) SKIN, NAILS, & HAIR Skin - Diaphoresis (with pheochromocytoma) NEUROLOGIC Central Nervous System - Headache (with pheochromocytoma) - Cranial nerve palsies can arise with head and neck paragangliomas Behavioral Psychiatric Manifestations - Anxiety (with pheochromocytoma) NEOPLASIA - Paragangliomas - Multiple tumors in 28% of patients - Paragangliomas, head and neck (31%) - Chemodectomas - Carotid body tumors - Glomus jugular tumors - Pheochromocytomas, adrenal (28%) - Pheochromocytomas, extraadrenal (48%) - Malignancy (34%) - Gastrointestinal stromal tumors (less common) - Renal cell carcinoma (less common) - Neuroblastoma (less common) LABORATORY ABNORMALITIES - Increased urinary catecholamines (with pheochromocytoma) MISCELLANEOUS - Adult onset (mean 30 years, range 10-65 years) - Incomplete penetrance (range 13% to 77% by 50 years of age) - Signs and symptoms depend on tumor location and activity - Patients may have head and neck paragangliomas only, adrenal or extraadrenal pheochromocytomas only, or both - See also PGL1 ( 168000 ) MOLECULAR BASIS - Caused by mutation in the succinate dehydrogenase complex subunit B gene (SDHB, 185470.0001 ) ▲ Close
- Wet-Tail Wikipedia
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Villonodular Synovitis
Wikipedia
"Pigmented villonodular synovitis and giant cell tumor of the tendon sheath: scintigraphic findings in 10 cases". Clinical Nuclear Medicine . 28 (11): 881–5. doi : 10.1097/01.rlu.0000093083.77866.5c . ... "Pigmented villonodular synovitis: radiologic-pathologic correlation". Radiographics . 28 (5): 1493–518. doi : 10.1148/rg.285085134 .
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Coeliac Disease
Wikipedia
Almost all people (95%) with coeliac disease have either the variant HLA-DQ2 allele or (less commonly) the HLA-DQ8 allele . [28] [60] However, about 20–30% of people without coeliac disease have also inherited either of these alleles. [61] This suggests additional factors are needed for coeliac disease to develop; that is, the predisposing HLA risk allele is necessary but not sufficient to develop coeliac disease. ... Therefore, these forms of the receptor are more likely to activate T lymphocytes and initiate the autoimmune process. [28] HLA region of chromosome 6 Most people with coeliac bear a two-gene HLA-DQ2 haplotype referred to as DQ2.5 haplotype . ... These are storage proteins rich in proline ( prol- ) and glutamine ( -amin ) that dissolve in alcohols and are resistant to proteases and peptidases of the gut. [28] [72] Prolamins are found in cereal grains with different grains having different but related prolamins: wheat (gliadin), barley ( hordein ), rye ( secalin ) and oats ( avenin ). [49] One region of α-gliadin stimulates membrane cells, enterocytes , of the intestine to allow larger molecules around the sealant between cells. ... This innate response to gliadin results in immune-system signalling that attracts inflammatory cells and increases the release of inflammatory chemicals. [28] The strongest and most common adaptive response to gliadin is directed toward an α2-gliadin fragment of 33 amino acids in length. [28] The response to the 33mer occurs in most coeliacs who have a DQ2 isoform . ... This would trigger killing of enterocytes by lymphocytes in the epithelium . [28] The villous atrophy seen on biopsy may also be due to unrelated causes, such as tropical sprue , giardiasis and radiation enteritis .MYO9B, HLA-DQB1, HLA-DQA1, BACH2, THEMIS, IL15, ZMIZ1, IFNG, CTLA4, HLA-DPB1, TGM2, ICOSLG, IL21, ETS1, MMP3, CXCL10, FCGR3A, MAGI2, UBD, CXCL11, MMP12, CD80, TFF1, APOB, TNFRSF9, ASAH2, CD36, CXCL9, LRAT, LPL, LCN2, CAPN8, TNFRSF14, CCR4, UGT1A4, IFI27, UPB1, SLC6A14, ACE, PIWIL2, VNN1, SOAT2, PCK1, RUNX3, GBP5, APOC3, S100A9, IL2, CD28, IL12A, SH2B3, ICOS, TAGAP, LPP, HLA-DQA2, IL23R, KIAA1109, CCR3, IL2RA, CIITA, ATG16L1, IL18R1, SMAD3, FUT2, PPP1R12B, FRMD4B, CD247, PUS10, MMEL1, ZNF335, PLEK, YDJC, NFIA, NCF2, POU2AF1, NKAIN2, IRF1-AS1, MST1, HECTD4, LURAP1L, SLC9A4, LINC02649, C1orf141, LINC01185, PTEN, CRB1, MROH3P, PTPRK, LINC01934, LINC00993, IL12A-AS1, IL6, IL10, LINC00824, IL12RB1, LINC01250, IL17A, INS-IGF2, MICA, IRF4, IRF5, AFF3, NONOP2, UQCRC2P1, C6orf99, ADCY7, ATXN2, RBM45, TNPO3, ELMO1, MYNN, SMG7, TNFSF15, INAVA, DLEU1, UBASH3A, SRCAP, IGF2-AS, ATXN2L, FNBP1, FOXP3, CNTNAP2, PHLDB1, ADGRL2, NRXN1, ARHGAP31, ERAP2, RMI2, LRRK2, SPIB, STAT3, STAT4, SUOX, TCF4, TNF, CARD9, WNT3, ANKRD30A, GATD3A, TMEM187, NKD1, ANKRD55, ACACA, PTPN2, DAG1, ABCC6, RUNX1, ZFP36L1, HLA-DRB1, GPR35, ACAD8, HP, PTPN22, IL18, LINC01193, IL18RAP, CFTR, PREP, CELIAC2, CXCL8, TLR4, AGA, HLA-A, IL1B, HT, HFE, IL4, IL22, NXF1, USO1, TLR2, TOR1A, FLNB, SEC14L2, FCGR2A, KIR3DL1, CD14, NOS2, INS, IL1A, TRBV20OR9-2, NLRP3, STAT1, HLA-C, ICAM1, MMP1, TGM6, IBD5, MBL2, PON1, VDR, GOT2, CXCR3, TPO, DMD, HSPA1A, EGFR, KLRK1, TAP2, DEFB1, GEM, KLRC4-KLRK1, NTS, CCR9, SLC11A2, HSPA1B, BEST1, TGFB1, IRF1, HMGB1, HLA-G, MYD88, ISYNA1, HLA-DRB4, NFKB1, RGS1, CRP, CCK, SCHIP1, TNFRSF8, VEGFA, TSLP, CD19, TXN, TNFAIP3, REG1A, CD38, TJP1, CD59, CX3CL1, SDC1, PARD3, TG, TFRC, TLR9, CDR3, HIF1A, CNR2, DLG5, HLA-DRB3, FAS, ISG20, PAEP, ATP12A, CTNNB1, ATP4A, HLA-DPA1, IL15RA, KLRC2, MLH1, MIF, DEFA5, IFNA13, IFNA1, IL12B, MTHFR, IL5, CLDN2, GHRL, TOLLIP, NELFCD, IL23A, ISCU, TBC1D9, COX8A, GINS2, ACSL5, CLDN3, CTSB, CX3CR1, CLEC16A, CCN2, TRDC, CADM1, B3GAT1, TRDD3, TRAV26-1, TRDJ1, DLL1, CD209, PGPEP1, IGHV5-51, HPGDS, SPINK4, LAMP3, CLDN15, GBGT1, CSN2, IBD6, ULK3, CR2, CPOX, TBC1D7, CHMP2B, QPCT, TLR7, IGF1, ODR4, BCL2, ATD, BAK1, BAX, GSTK1, IRGM, BCKDHB, STPG4, OR10A4, TICAM1, NAPEPLD, SLC30A8, OLIG3, TMPRSS6, CST13P, NKX2-3, BDNF, MIR155, DEFB103A, HCG14, KIR2DL5B, PARP1, ADRA1A, AHR, ALB, ALK, OCLN, LINC01672, AMELX, AD12, AMH, ANPEP, ZGLP1, CCR2, ANXA11, APC, CFB, TRIM69, CCR5, KIR2DL5A, CD34, IFIH1, CD44, CD48, C6orf47, ZFAT, CDKN2A, CDKN2D, SLCO6A1, PNPLA2, DEFB103B, CHI3L1, CLC, IFT122, SLC30A10, CCR1, FTO, VTCN1, CD86, EHMT1, ADAD1, IL17RE, CD1D, CD3E, CD3G, CD4, MTG1, CD8A, IL33, ATAD1, NCALD, PNPLA3, TRABD, NLRP1, BTNL8, CCDC33, FCGRT, DMRT1, NHS, SERPINF1, PDGFB, GRINA, PBX3, TNFRSF11B, NT5E, NOS1, NFKBIB, DUSP10, GTF2A1, NDUFA2, GZMB, NCAM1, MUC1, MSH5, MSH2, ABCB1, SERPINA1, PI3, SERPINE2, GNAO1, PTH, PSMB6, PRL, PRKCQ, PRKCD, PPP6C, PON3, PON2, PML, PLA2G4A, PIK3CG, PIK3CD, PIK3CB, PIK3CA, HLA-B, MME, MLN, KIR3DL2, KCNJ11, IRF2, IRAK1, INSR, HNRNPD, IL13, IL12RB2, HSPA2, HSPD1, IL9, IL6R, IDDM3, IL5RA, IL2RB, IGHA1, KIR2DS1, L1CAM, HLA-DMB, LCT, MICB, HLA-DOA, MGMT, MEFV, MCL1, SMAD7, SMAD2, LYZ, LTBR, LTA, LSAMP, HLA-DQB2, LMO2, LMO1, LGALS1, PTPRC, GLS, RAC2, NCR1, COX5A, F2, HSPB3, F9, FAAH, TNFSF13, MADD, IGFALS, MTOR, SCG2, ZFP36, YY1, FUT4, VIP, UBE2L3, ETFA, ERBB2, TPMT, ELN, LILRA3, BTNL3, DNAH8, TNFSF13B, GNA13, CD226, DPP4, KAT5, CLEC10A, SEMA3A, PRSS16, OPTN, ABCB6, EGF, ELAVL2, TSHR, TNFRSF1A, RAG1, GH1, GLB1, SOX9, SOD1, SLC22A4, SLC6A4, SGK1, SELL, SELE, GLI1, CCL5, CCL2, GLI2, S100B, GLP1R, SNORA73A, SPINK1, STAT6, GABBR1, GCG, CLDN5, TLR3, TIMP1, TIA1, GAD1, TGM1, TGFB3, TGFA, TFF3, GAD2, TRD, TCN2, GATA3, TBX1, TAP1, H3P13
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Pulmonary Bullae Causing Pneumothorax
Omim
Gibson (1977) described 3 sisters with repeated pneumothoraces beginning at ages 28, 32 and 37 years. Bullae were present in otherwise normal lungs.
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Hypertryptophanemia
Omim
Cleary et al. (1998) concluded that there is no ill effect from elevated plasma tryptophan and no indication for dietary treatment, and that hypertryptophanemia should be regarded as a benign condition. Ferreira et al. (2017) studied a 28-year-old woman who had been found to have hypertryptophanemia on newborn screening in Canada (McCoy and Ferreira, 1987). ... Reevaluation at age 26 years, after the proband had completed a university education, showed elevated tryptophan and serotonin levels, a 24-hour urinary 5-HIAA in the high normal range, and a normal melatonin level. At age 28 years, because she was considering pregnancy, normalization of tryptophan and serotonin by dietary means was attempted, using various combinations of natural and medical protein ratios. ... The proband's parents were unrelated and had completely normal tryptophan levels; her brother declined testing. Molecular Genetics In a 28-year-old woman with congenital hypertryptophanemia, Ferreira et al. (2017) sequenced the TDO2 gene and identified compound heterozygosity for a 1-bp duplication (191070.0001) and a missense mutation (M108I; 191070.0002).
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Abortion In Moldova
Wikipedia
Abortion in Moldova is legal on request within the first 12 weeks of pregnancy, and generally permitted until 28 weeks for a broad variety of reasons determined by the Ministry of Health . The Ministry of Health orders permit abortions until 22 weeks in the event of a threat to health, a pregnancy that results from a crime, a fetus with genetic defects or for social reasons, and abortions are permitted until 28 weeks if the fetus has severe malformations or congenital syphilis . ... She was freed in 2012 after international pressure. [6] References [ edit ] ^ "Law No. 411 of 28 March 1995 on health; Criminal Code, 18 April 2002, as amended through 2008" . 2008 .
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Celibacy Syndrome
Wikipedia
"No, Japanese People Haven't Given Up on Sex" . Slate . Retrieved 28 December 2014 . ^ Scott, Carl (13 October 2013). " " Yuko and Hiro" Do Not Despise Sex" . First Things . Retrieved 28 December 2014 . ^ a b Matthews, Dylan (23 October 2013). ... Archived from the original on 4 July 2015 . Retrieved 28 December 2014 . v t e Human sexuality and sexology Sexual relationship phenomena Asexuality Gray asexuality Bisexuality Casual relationship Casual sex Celibacy Celibacy syndrome Herbivore men Committed relationship Conventional sex Free love Foreplay Heterosexuality Homosexuality Hypersexuality Marriage One-night stand Polyamory Promiscuity Female Romantic love Romantic orientation Flirting Sex life Sexual abstinence Sexual orientation Sexual partner Single person Swinging Sexual dynamics Hypergamy Intersex Physical attractiveness Sexual attraction Sexual capital Sexual ethics Sexual frustration Sociosexuality See also Sexual addiction Sex Addicts Anonymous Sex-positive movement Sexual surrogate v t e Outline of human sexuality Physiology and biology Erection Insemination Intersex Libido Nocturnal emission Orgasm Female and male ejaculation Pelvic thrust Pre-ejaculate Pregnancy Sexual arousal Sexual stimulation Health and education Birth control Condom Masters and Johnson Reproductive medicine Andrology Gynaecology Urology Safe sex Sex education Sex therapy ( PLISSIT model ) Sexology Sexual dysfunction Erectile dysfunction Hypersexuality Hyposexuality Sexual medicine Sexual surrogate Sexually transmitted infection Identity and diversity Gender binary Gender identity Men who have sex with men Sexual identity Sexual orientation Women who have sex with women Law Age of consent Criminal transmission of HIV Child sexual abuse Incest Indecent exposure Obscenity Sexual abuse Cybersex trafficking Rape Sex trafficking Sexual assault Sexual harassment Sexual misconduct Sexual slavery Sexual violence History Blue Movie Counterculture of the 1960s Feminist sex wars Golden Age of Porn History of erotic depictions Sexual revolution Relationships and society Anarchism and love/sex Extramarital sex Family planning Flirting Free love Marriage Modesty Polyamory Premarital sex Promiscuity Romance Sex-positive movement Sexual abstinence Sexual addiction Sexual attraction Sexual capital Sexual ethics Sexual objectification Sexual slang By country Ancient Rome China India Japan Philippines South Korea United States Sexual activities Conventional sex Anal sex Bareback BDSM Child sex Creampie Edging Erotic sexual denial Fetishism Fingering Fisting Gang bang Group sex Masturbation Mechanics of sex Nipple stimulation Non-penetrative sex Facial Foot fetishism Footjob Forced orgasm Frot Handjob Mammary intercourse Sumata Oral sex 69 Anilingus Cunnilingus Fellatio Irrumatio Paraphilia Pompoir Quickie Sex in space Sex positions Sexual fantasy Sexual fetishism Sexual intercourse Foreplay Sexual penetration Swinging Tribadism Urethral intercourse Urolagnia Virtual sex Cybersex Erotic talk Wet T-shirt contest Sex industry Red-light district Adult video games Erotica Pornography Film actor Prostitution Survival sex Sex museum Sex shop Sex tourism Child Female Sex worker Sex toy doll Strip club Webcam model Religion and sexuality Buddhism Christian demonology Daoism Islam Mormonism Sex magic Human sexuality portal
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Aortic Aneurysm, Familial Thoracic 4
Omim
A daughter of the proband, who had a PDA repaired at age 6, died at age 28 of an extensive dissection of the descending thoracic and abdominal aorta. One son was found to have a small PDA and an aneurysm extending from the aortic sinuses to the diaphragm at age 28, and underwent repair of both but died of left ventricular failure in the early postoperative period. ... In the American kindred described by Glancy et al. (2001), they detected a 72-nucleotide deletion within exon 28 of the MYH11 gene (160745.0002). Pannu et al. (2007) sequenced the MYH11 gene in 3 probands from 3 families with nonsyndromic thoracic aortic aneurysm and dissection (TAAD) in which 1 or more members had patent ductus arteriosus (PDA) and in 93 probands from unrelated TAAD families without PDA, and identified 2 closely linked missense mutations in 1 of the 3 TAAD/PDA families (160745.0003 and 160745.0004) and a different missense mutation in another of the 3 TAAD/PDA families (160745.0005).
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Social-Emotional Agnosia
Wikipedia
Unlike the previously mentioned studies regarding amygdala lesions, these monkeys demonstrated problems with visual perception. [5] References [ edit ] ^ "Medical Education for Undergraduate MD Students ." Agnosia. N.p., 14 Apr 2011. Web. 28 Nov 2011. ^ Schmitz, Bettina, and Michael Trimble. ... Brain-Mind. Academic Press, 2000. Web. 28 Nov 2011. ^ a b "The amygdala theory of autism." ... Brain-Mind. Academic Press, 2000. Web. 28 Nov 2011 ^ a b Corbett, Blythe, and David Amaral. ... "Cognitive & Emotional Neural Networks the Hippocampus, Amygdala, & Memory ." Brain-Mind. N.p., 1996. Web. 28 Nov 2011. ^ a b Joseph, Rhawn. "Environmental Influences on Neural Plasticity, the Limbic System, Emotional Development and Attachment: A Review."