Contents 1 Symptoms 2 Pathophysiology 3 Diagnosis 4 Treatment 5 Prognosis 6 Epidemiology 7 References Symptoms [ edit ] Amyloid cardiomyopathy is associated with a number of symptoms: diastolic dysfunction [4] congestive heart failure [5] arrythmia [5] cardiac nervous conduction block [5] fatigue [6] dyspnea [6] Pathophysiology [ edit ] Amyloid proteins are deposited in the myocardium . [5] This limits ventricular filling during diastole , which increases end-diastolic volume . [5] This can lead to a variety of cardiac issues, such as congestive heart failure, atrial arrythmia, ventricular arrythmia, and blocks to cardiac nervous conduction. [5] Diagnosis [ edit ] Diagnosis is often delayed, because its symptoms are non-specific. [7] Electrocardiography can be used to identify low voltage and patterns similar to those of a heart attack . [6] Cardiac MRI can be used to distinguish it from hypertensive heart disease . [4] [6] This shows a thicker interventricular septum . [6] Treatment [ edit ] Chemotherapy can treat amyloidosis if it is related to immunoglobulins . [7] Liver transplant can treat amyloidosis if it is related to familial transthyretin . [7] Prognosis [ edit ] Outcomes for amyloid cardiomyopathy are generally very poor, with fewer than 10% of patients surviving more than 5 years . [5] Without treatment, few patients survive more than 6 months. [5] Epidemiology [ edit ] In developed countries, amyloid cardiomyopathy is estimated to be involved in 0.1% of deaths. [5] References [ edit ] ^ "Cardiac amyloidosis: MedlinePlus Medical Encyclopedia" . medlineplus.gov . ... PMID 20109604 . ^ a b Steingart, Richard M.; Chen, Carol; Liu, Jennifer (2016-01-01), Herrmann, Joerg (ed.), "Chapter 7 - Subtypes of Cancer Involving the Heart" , Clinical Cardio-Oncology , Elsevier, pp. 121–131, doi : 10.1016/b978-0-323-44227-5.00007-7 , ISBN 978-0-323-44227-5 , retrieved 2020-11-27 ^ a b c d e f g h i Gillespie, Hamilton S.; Benjamin, Ivor J. (2012-01-01), Hill, Joseph A.; Olson, Eric N. (eds.), "Chapter 43 - Infiltrative and Protein Misfolding Myocardial Diseases" , Muscle , Boston/Waltham: Academic Press, pp. 625–637, doi : 10.1016/b978-0-12-381510-1.00043-0 , ISBN 978-0-12-381510-1 , retrieved 2020-11-27 ^ a b c d e Benson, Merrill D. (2013-01-01), Rimoin, David; Pyeritz, Reed; Korf, Bruce (eds.), "Chapter 79 - Amyloidosis and Other Protein Deposition Diseases" , Emery and Rimoin's Principles and Practice of Medical Genetics , Oxford: Academic Press, pp. 1–18, doi : 10.1016/b978-0-12-383834-6.00083-5 , ISBN 978-0-12-383834-6 , retrieved 2020-11-27 ^ a b c Sher, T.; Gertz, M. ... (eds.), "Amyloid Cardiomyopathy" , Encyclopedia of Cardiovascular Research and Medicine , Oxford: Elsevier, pp. 66–79, doi : 10.1016/b978-0-12-809657-4.11051-8 , ISBN 978-0-12-805154-2 , retrieved 2020-11-27 v t e Medicine Specialties and subspecialties Surgery Cardiac surgery Cardiothoracic surgery Colorectal surgery Eye surgery General surgery Neurosurgery Oral and maxillofacial surgery Orthopedic surgery Hand surgery Otolaryngology ENT Pediatric surgery Plastic surgery Reproductive surgery Surgical oncology Transplant surgery Trauma surgery Urology Andrology Vascular surgery Internal medicine Allergy / Immunology Angiology Cardiology Endocrinology Gastroenterology Hepatology Geriatrics Hematology Hospital medicine Infectious disease Nephrology Oncology Pulmonology Rheumatology Obstetrics and gynaecology Gynaecology Gynecologic oncology Maternal–fetal medicine Obstetrics Reproductive endocrinology and infertility Urogynecology Diagnostic Radiology Interventional radiology Nuclear medicine Pathology Anatomical Clinical pathology Clinical chemistry Cytopathology Medical microbiology Transfusion medicine Other Addiction medicine Adolescent medicine Anesthesiology Dermatology Disaster medicine Diving medicine Emergency medicine Mass gathering medicine Family medicine General practice Hospital medicine Intensive care medicine Medical genetics Narcology Neurology Clinical neurophysiology Occupational medicine Ophthalmology Oral medicine Pain management Palliative care Pediatrics Neonatology Physical medicine and rehabilitation PM&R Preventive medicine Psychiatry Addiction psychiatry Radiation oncology Reproductive medicine Sexual medicine Sleep medicine Sports medicine Transplantation medicine Tropical medicine Travel medicine Venereology Medical education Medical school Bachelor of Medicine, Bachelor of Surgery Bachelor of Medical Sciences Master of Medicine Master of Surgery Doctor of Medicine Doctor of Osteopathic Medicine MD–PhD Related topics Alternative medicine Allied health Dentistry Podiatry Pharmacy Physiotherapy Molecular oncology Nanomedicine Personalized medicine Public health Rural health Therapy Traditional medicine Veterinary medicine Physician Chief physician History of medicine Book Category Commons Wikiproject Portal Outline This article about a medical condition affecting the circulatory system is a stub .
TTR,
GSN,
DPYD,
NPPB,
APOA1,
PART1,
SULT1E1,
TNNT1,
VEGFA,
LSR,
RBP4,
DCLRE1B,
MANEA,
C16orf82,
C4orf3,
MIR155,
MIR29A,
SNCA,
SERPINA1,
PPP1R1A,
APOE,
NEFL,
IAPP,
HTT,
FXN,
GPC5,
FBN1,
FAP,
CTSE,
CRP,
CLU,
CACNA1A,
MIR339
