Common types [ edit ] Ichthyosis [ edit ] Ichthyosis refers mainly to ichthyosis vulgaris , a common genodermatosis, people with this disease have a fishy, dry skin, which usually appears in early childhood and may disappear in adulthood.  The prevalence of ichthyosis vulgaris is high, affecting almost 1 per 250 people.  There are also rare types of ichthyosis, such as epidermolytic hyperkeratosis, harlequin ichthyosis and so on.  Rare types [ edit ] Michelin tyre baby syndrome [ edit ] Michelin tyre baby syndrome is a rare genodermatosis that occurs at birth, the skin of the patients is stacked symmetrically in layers like the image of the Michelin tyre’s mascot, which is also how this disease got its name.  Epidermolysis bullosa [ edit ] Epidermolysis bullosa is a rare type of genodermatosis, people with this disease have blisters on their skin and this disease is never completely cured for a lifetime.  Epidermolysis bullosa is mainly subdivided into four types: dystrophic epidermolysis bullosa , epidermolysis bullosa simplex, junctional epidermolysis bullosa and kindler syndrome .  Almost 1 in 50,000 people has epidermolysis bullosa.  Pachyonychia congenita [ edit ] Dystrophic epidermolysis bullosa Epidermolytic hyperkeratosis Hidrotic ectodermal dysplasia Pachyonychia congenita is a rare type of genodermatosis, its clinical manifestations are abnormal enlargement of fingernails or toenails, excessive or poor palmoplantar keratinization, excessive sweating in the palmar or the plantar.  Between 5000 and 10000 people in the world suffer from pachyonychia congenita.  Epidermolytic palmoplantar keratoderma [ edit ] Epidermolytic palmoplantar keratoderma often appears at birth and it is almost impossible to be cured completely.  The clinical manifestations of this disease include excessive palmoplantar keratinization, the palmar or plantar become yellow divergently with around the edges or abnormally excessive sweating and clinical manifestation appear in a symmetrical form on the body.  Hereditary benign intraepithelial dyskeratosis [ edit ] Hereditary benign intraepithelial dyskeratosis is a rare type of genodermatosis that may occur in infancy and early childhood, its symptoms often appear in the patients’ eyes and mouths.  The patients’ eyes appear red due to the dilatation of superficial vessels and appearance of conjunctival plaques in their eyes, patients may have variable-size, thick, soft and white plaques in their mouth.  Spring is an acute episode of symptoms, such as itching, erythema, photophobia and so on.  Epidermolytic hyperkeratosis [ edit ] Epidermolytic hyperkeratosis is a rare genodermatosis which is also referred to as disorder of cornification type 3 and bullous congenital ichthyosiform erthroderma, affecting almost 1 per 200,000 - 300,000 people.  They also stated that its clinical manifestations often begin at birth with large rashes all over the body, and the patients’ skin will be so sensitive that even mild wounds can cause blisters and peeling. ... Ichthyosis [ edit ] There is no radical therapeutic method for ichthyosis, but some care can ease the symptoms.  To prevent skin thickening and hydrate skin, patients can apply a cream containing alpha hydroxy acids and patients can also be treated with antibiotics for subsequent infections.  Epidermolysis bullosa [ edit ] For epidermolysis bullosa, daily care is important. ... Avery's Diseases of the Newborn . pp. 1475–1494.e1. doi : 10.1016/B978-0-323-40139-5.00104-2 . ISBN 978-0-323-40139-5 . ^ a b Tantcheva-Poór, Iliana; Oji, Vinzenz; Has, Cristina (October 2016). ... Journal der Deutschen Dermatologischen Gesellschaft . 14 (10): 969–986. doi : 10.1111/ddg.13140 . ... Cold Spring Harbor Perspectives in Medicine . 4 (10): a015172. doi : 10.1101/cshperspect.a015172 .