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Cerebral Amyloid Angiopathy, App-Related
OMIM
A number sign (#) is used with this entry because cerebral amyloid angiopathy (CAA) can be caused by mutation in the gene encoding the amyloid precursor protein (APP; 104760). Mutations in the APP gene can also cause autosomal dominant Alzheimer disease-1 (AD1; 104300), which shows overlapping clinical and neuropathologic features. ... Revesz et al. (2003) reviewed the pathology and genetics of APP-related CAA and discussed the different neuropathologic consequences of different APP mutations. ... In 4 affected members of an Italian family with cerebral amyloid angiopathy, Obici et al. (2005) identified a mutation in the APP gene (104760.0019). In 2 brothers from an extensive Iowa kindred with progressive dementia and cerebroarterial amyloidosis, Grabowski et al. (2001) identified a heterozygous mutation in the APP gene (N694D; 104760.0016). ... Human APP mRNA was detected in neurons and neuronal processes, but not in vessel walls. ... Herzig et al. (2006) extended their earlier studies by developing several murine models of APP-related CAA and APP-related parenchymal amyloid deposition.
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Familial Amyloid Cardiomyopathy
Wikipedia
Marked axis deviation, bundle branch block , and AV block are common, as is atrial fibrillation . ... Med. 363, 1464-1470. v t e Amyloidosis Common amyloid forming proteins AA ATTR Aβ2M AL Aβ / APP AIAPP ACal APro AANF ACys ABri Systemic amyloidosis AL amyloidosis AA amyloidosis Aβ2M/Haemodialysis-associated AGel/Finnish type AA/Familial Mediterranean fever ATTR/Transthyretin-related hereditary Organ-limited amyloidosis Heart AANF/Isolated atrial Brain Familial amyloid neuropathy ACys+ABri/Cerebral amyloid angiopathy Aβ/Alzheimer's disease Kidney AApoA1+AFib+ALys/Familial renal Skin Primary cutaneous amyloidosis Amyloid purpura Endocrine Thyroid ACal/Medullary thyroid cancer Pituitary APro/Prolactinoma Pancreas AIAPP/Insulinoma AIAPP/Diabetes mellitus type 2
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Inclusion Body Myositis
OMIM
The authors discussed the abnormalities of APP processing, the role of abnormal intracellular protein folding, oxidative stress, and the potential role of cholesterol in the pathogenic cascade of IBM. ... Accumulation of the amyloid-beta peptide, which is derived from proteolysis of the larger beta-APP, seems to be an early pathologic event in both Alzheimer disease and IBM; in the latter, it occurs predominantly intracellularly within affected myofibers. To elucidate the possible role of beta-APP mismetabolism in the pathogenesis of IBM, Sugarman et al. (2002) selectively targeted beta-APP overexpression to skeletal muscle in transgenic mice, using the muscle creatine kinase promoter. They reported that older (more than 10 months) transgenic mice exhibited intracellular immunoreactivity to beta-APP and its proteolytic derivatives in skeletal muscle. In this transgenic model, selective overexpression of beta-APP led to the development of a subset of other histopathologic and clinical features characteristic of IBM, including centric nuclei, inflammation, and deficiencies in motor performance.GNE, NT5C1A, APP, TARDBP, HLA-DRB1, SQSTM1, APOE, KHDRBS1, NUP62, DCTN4, GTF2H1, SDC1, CDR3, GSN, MAPT, TRBV20OR9-2, HLA-C, PLAAT4, FYCO1, MSTN, TNFRSF12A, NFAT5, CCR2, UBB, MALAT1, VCP, RBM45, AOC3, DCD, UCN2, DNAJB6, OPTN, KLRG1, MAP1LC3A, LILRB1, KDELR1, ICOSLG, SYNM, ROBO3, DDX58, CHMP1B, PABPC1, TIMP1, RRM2B, TWNK, FOXP3, KRT20, TTR, ACTB, THBS1, CST3, HLA-DQA1, HK1, H1-0, NR3C1, EPHB2, EMD, DES, CD47, TGFB1, CD38, CD36, CD34, MS4A1, CAPN3, BCL2, AOC2, HLA-DRB3, HMGB1, IFN1@, IFNG, TRIM21, AGER, MOK, PTPRC, PSME1, PSMB10, MAPK1, POLG, PMP22, MMP9, MMP1, MLF1, LMNA, IL6, IL1B, LOC102723996
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Angioedema Induced By Ace Inhibitors, Susceptibility To
OMIM
Clinical Features Blais et al. (1999) and Adam et al. (2002) reported significantly lower plasma aminopeptidase P (APP) activities in patients with a history of AEACEI. ... Measured genotype analysis strongly suggested that the linkage signal for APP activity at this locus was accounted for predominantly by the SNP association. ... There was a significant association between the -2399A allele and decreased serum APP activity in both men and women, but the APP activity was lower in men regardless of genotype. ... This haplotype was associated with decreased plasma APP activity and decreased luciferase gene expression compared to other haplotypes of these SNPs. Cilia La Corte et al. (2011) concluded that the ATG haplotype of XPNPEP2 is functional and contributes to the development of ACEi-angioedema through a reduction in APP activity.
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Alzheimer Disease 18
OMIM
Q170H and R181G mutant mice showed significant attenuation of APP processing compared to wildtype, with a decrease in APP-CTF-alpha levels and an increase in sAPP-beta levels, indicating that the mutations attenuated Adam10 alpha-secretase activity on APP. Crossing these Adam10 mutant mice with the Tg2576 AD mouse model showed that the Adam10 mutations increased amyloidogenic APP processing, as manifest by a shift from the alpha-secretase to the amyloidogenic beta-secretase pathway. ... Collectively, these findings suggested that diminished alpha-secretase activity of ADAM10 on APP resulting from mutations in the ADAM10 prodomain can cause AD-related pathology.
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Early-Onset Alzheimer's Disease
Wikipedia
This loss of brain volume affects ones ability to live and function properly, ultimately being fatal. [5] Beta-amyloid is a small piece of a larger protein called the amyloid precursor protein (APP). Once APP is activated, it is cut into smaller sections of other proteins. ... Alpha-secretase cleavage of APP, which precludes the production of Aβ, is the most common processing event for APP. 21 allelic mutations have been discovered in the APP gene. These guarantee onset of early-onset familial Alzheimer disease and all occur in the region of the APP gene that encodes the Aβ domain. ... "A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid". ... PMID 16817891 . ^ Chow VW, Mattson MP, Wong PC, Gleichmann M (March 2010). "An overview of APP processing enzymes and products" .
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Alzheimer Disease
OMIM
See also APP-related cerebral amyloid angiopathy (CAA; 605714), which shows overlapping clinical and neuropathologic features. ... Genetic analysis identified a mutation in the APP gene (V717I; 104760.0002). Farlow et al. (1994) reviewed the clinical characteristics of the disorder in the AD family reported by Murrell et al. (1991) in which affected members had a mutation in the APP gene (V717F; 104760.0003). ... Rovelet-Lecrux et al. (2006) estimated that in their whole cohort of 65 ADEOAD families, the frequency of the APP locus duplication was roughly 8% (5 of 65), which corresponds to half of the contribution of APP missense mutations to ADEOAD. ... Revesz et al. (2003) reviewed the pathology and genetics of APP-related CAA and discussed the different neuropathologic consequences of different APP mutations. ... Further studies indicated that suppression of PPARGC1A in hyperglycemia resulted in activation of the FOXO3A (602681) transcription factor, which inhibits nonamyloidogenic secretase processing of APP and promotes amyloidogenic processing of APP.TOMM40, TREM2, ABCA7, APP, APOE, PSEN2, PSEN1, MAPT, SORL1, PRNP, CASP3, BACE1, GSK3B, NCSTN, IDE, IL1B, HFE, A2M, ACE, DHCR24, BIN1, ESR1, ADAM10, ADAMTS1, PGRMC1, VEGFA, ARC, CYP46A1, SLC30A4, VSNL1, PICALM, HMOX1, HLA-DRB5, IGF1R, IGF1, INPP5D, IGF2, MPO, NPY, NOS3, PLAU, PLCG2, PPARG, RELN, MTHFR, PYY, NECTIN2, SLC2A4, IGF2R, SOD2, MAOB, TF, LEP, TFAM, INSR, INS, TNF, TPI1, EPHA1, F2, ENO1, CR1, CASS4, ATP5F1A, CLU, CHRNB2, CHRNA7, MIR766, CD33, IQCK, EIF2S1, MIR505, APOC1, CALM1, MIR100, MIR146A, BDNF, BCL2, MIR375, MIR296, BCHE, MIR708, TPP1, SLC30A6, SNAR-I, DPYSL2, ACHE, CD2AP, GAPDHS, PCDH11X, CYP2D6, MIR4467, CRH, MIR3622B, BAX, AMFR, ABI3, CST3, MS4A4A, WWOX, BRCA2, FANCD2, TFF1, TAS2R64P, CTNNB1, SUCLA2, SNCA, CTSD, RNR2, NEFL, TAS2R62P, SOD1, ITPR3, ITPR2, ITPR1, FLAD1, PSENEN, TP53, CDK5R1, EIF2AK3, UBQLN1, ALG3, PIK3CG, PIK3CA, PIK3CD, SERPINA3, PIK3CB, DOCK3, APLP1, OGDH, CREB1, NOTCH1, CASP6, NGF, CCND1, FOS, DLX4, DLG4, DDIT3, RABGEF1, PEBP1, PYCARD, DAPK2, KCNIP3, CTSB, CSF2, CRMP1, CTSG, EHMT2, ENO2, ERBB4, TMED10, TERF2IP, PTK2B, FCN2, PTGES3, FGF2, ACKR1, DNM1L, SDC3, G6PD, GCHFR, ITM2B, CREBBP, MAP3K8, TRPM7, ADI1, MTCO2P12, UPK3B, ACTB, AKT1, AKT2, ANXA1, APBB1, DNLZ, STS, MIR34A, BRCA1, MIR137, C5AR1, DDR1, CAMK4, TMED10P1, MPEG1, C9orf72, ESCO1, CDCA5, PRRT2, MAP1LC3B, CAT, EHMT1, CNR2, SPPL2B, RAB9A, NRXN3, GFAP, SYNJ1, SERPINB5, CD99, MME, MNAT1, CCL2, RRAS, RPS27, RPS21, RAP1A, PYCR1, COX2, PTS, PTGS2, MTHFD1, MMUT, NCAM1, NFIA, NFIB, MAPK8, MAPK3, PRKCB, PRKCA, PPBP, MED1, NFIC, PPARA, NFIX, PKD1, NOTCH3, NRGN, MEOX2, MEF2A, SPRR2A, TTC3, GRIN2A, DENR, GRIN2B, RAB7A, LRP8, HPRT1, HSP90AA1, VIM, IDUA, UTRN, SUMO1, UBE2I, TTK, TPT1, SULT1E1, IL1A, IL6, IL12A, TSPAN6, TIE1, TGFB1, TG, KNG1, LAMC2, LGALS3, TERT, TERC, STIM1, H3P17
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Atrioventricular Block
Wikipedia
The signal travels from the SA node to the ventricles through the atrioventricular node (AV node). In an AV block, this electrical signal is either delayed or completely blocked. ... The electrical signal then travels to the AV node located on the lower portion of the interatrial septum . ... An ECG is used to differentiate between the different types of AV block. However, one important consideration when diagnosing AV blocks from ECGs is the possibility of pseudo- AV blocks which are due to concealed junctional extrasystoles. ... In a second-degree AV block, the impairment results in a failure to conduct an impulse, which causes a skipped beat. [9] Mobitz I [ edit ] Mobitz I is characterized by a progressive, yet, reversible block of the AV node. ... On ECG, there is no relationship between P waves and QRS complexes, meaning the P waves and QRS complexes are not in a 1:1 ratio. Third-degree AV block is the most severe of the AV blocks.LMNA, GNAI2, SCN5A, KCNH2, DES, KCNQ1, PRKAG2, TRPM4, TTN, ACADVL, MTM1, KCNJ5, MMP2, AGXT, SCN4B, MYBPC3, TTR, BVES, SYNE2, SYNE1, TMEM43, KCNJ2, MMP14, CACNA2D1, GLA, GPX4, FHL1, EMD, SLC25A20, NKX2-5, CALR, TDP2, ARSD, TBX5, TRIM21, ARFGEF1, GJC1, TOPORS, ITGAM, SDS, PKD2L1, CACNA1C, SMUG1, RHOA, APRT, ARID2, HCN4, TBX6, CALCR, TBX3, SSB, SLC6A8, SCN10A, CAV1, PKD2, PITX2, CUX1, FLT4, MFAP1, GATA4, KRT5, GNB2, MIR19B1
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Heart Block
Wikipedia
Blockages are therefore classified based on where the blockage occurs - namely the SA node (" Sinoatrial block "), AV node (" AV block " or AVB ), and at or below the bundle of His ("Intra-Hisian" or "Infra-Hisian block" respectively). ... Therefore, most of the important heart blocks are AV nodal blocks and infra-Hisian blocks. ... Sinus rhythm (rate = 100/min) with 3:2 and 2:1 Type II AV block; right bundle branch block Sinus tachycardia with complete AV block and resulting junctional escape Following the path of the electrical signals, the places where conduction can be blocked give rise to different kinds of heart blocks: Location Name Within the sinoatrial node (SA node or Sinus node), where the heart's signals originate Sinoatrial nodal blocks (often abbreviated "SA nodal block" or "SA block", sometimes written "Sinuatrial block") Within the atrioventricular node (AV node) Atrioventricular block (often abbreviated "AV nodal block", "AV block" or AVB). ... In an SA block, the electrical impulse is delayed or blocked on the way to the atria, thus delaying atrial depolarization. By contrast, an AV block occurs in the AV node and delays ventricular depolarization. ... In SA node suppression, on the other hand, the SA node doesn't generate an electrical impulse because it is reset by the electrical impulse that enters the SA node. AV nodal blocks [ edit ] There are three basic types of AV nodal block : First-degree AV block Second-degree AV block Type I second-degree AV block (Mobitz I), also known as a Wenckebach block [5] Type 2 second-degree AV block (Mobitz II) - due to a block in or below the bundle of His [5] Third-degree AV block (complete heart block) Infra-Hisian block [ edit ] Infra-Hisian block is that of the distal conduction system.
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Ataxia With Vitamin E Deficiency
GARD
Ataxia with vitamin E deficiency (AVED) is a progressive disease affecting motor control and movement. Symptoms of AVED include slurred speech (dysarthria), difficulty coordinating movements ( ataxia ), numbness in the hands and feet (peripheral neuropathy), and progressive leg weakness. ... Symptoms typically begin during childhood or adolescence and worsen with age, resulting in the need for a wheelchair by early adulthood. AVED is caused by a mutation to the TTPA gene. ... Vitamin E is important because it protects the cells of the neurological system (neurons) from dangerous molecules called free radicals. AVED is inherited in an autosomal recessive manner. Treatment for AVED includes vitamin E supplements, which will prevent AVED from developing if given before symptoms begin and may reverse some neurological symptoms if begun after AVED develops.
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First-Degree Atrioventricular Block
Wikipedia
First-degree AV block Other names First degree heart block, PR prolongation An ECG showing a first degree AV block of greater than 300 ms Specialty Cardiology Symptoms Asymptomatic Complications Progression to second or third degree AV block Causes Fibrosis in AV node, medication, vagal tone , electrolyte disturbances Diagnostic method Electrocardiogram Treatment Avoidance of AV-nodal-blocking medication First-degree atrioventricular block (AV block) is a disease of the electrical conduction system of the heart in which electrical impulses conduct from the cardiac atria to the ventricles through the atrioventricular node (AV node) more slowly than normal. First degree AV block does not generally cause any symptoms, but may progress to more severe forms of heart block such as second - and third-degree atrioventricular block . ... The medications that most commonly cause first-degree heart block are those that increase the refractory time of the AV node, thereby slowing AV conduction. ... Diagnosis [ edit ] In normal individuals, the AV node slows the conduction of electrical impulse through the heart. ... In first-degree heart block, the diseased AV node conducts the electrical activity more slowly.
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Alzheimer's Disease
Wikipedia
The hypothesis holds that an amyloid-related mechanism that prunes neuronal connections in the brain in the fast-growth phase of early life may be triggered by ageing-related processes in later life to cause the neuronal withering of Alzheimer's disease. [64] N-APP, a fragment of APP from the peptide's N-terminus , is adjacent to beta-amyloid and is cleaved from APP by one of the same enzymes. N-APP triggers the self-destruct pathway by binding to a neuronal receptor called death receptor 6 (DR6, also known as TNFRSF21 ). [64] DR6 is highly expressed in the human brain regions most affected by Alzheimer's, so it is possible that the N-APP/DR6 pathway might be hijacked in the ageing brain to cause damage. ... Osaka mutation A Japanese pedigree of familial Alzheimer's disease was found to be associated with a deletion mutation of codon 693 of APP. [65] This mutation and its association with Alzheimer's disease was first reported in 2008. [66] This mutation is known as the Osaka mutation. ... A β is a fragment from the larger amyloid precursor protein (APP). APP is a transmembrane protein that penetrates through the neuron's membrane. APP is critical to neuron growth, survival, and post-injury repair. [103] [104] In Alzheimer's disease, gamma secretase and beta secretase act together in a proteolytic process which causes APP to be divided into smaller fragments. [105] One of these fragments gives rise to fibrils of amyloid beta, which then form clumps that deposit outside neurons in dense formations known as senile plaques . [98] [106] AD is also considered a tauopathy due to abnormal aggregation of the tau protein .APP, ACE, TREM2, ADAM10, APOE, PSEN1, GSK3B, HFE, MAPT, PLAU, NPY, BCL2, CASP3, BDNF, IDE, INSR, IL1B, LEP, BACE1, IGF2, IGF1R, ATP5F1A, INS, BAX, CR1, A2M, ABCA7, TOMM40, CD2AP, BIN1, EPHA1, CLU, PICALM, NOS3, PSEN2, APOC1, MPO, SORL1, VSNL1, INPP5D, NECTIN2, MS4A4A, PCDH11X, CASS4, BCHE, MIR146A, CYP46A1, DHCR24, CHRNA7, NCSTN, VEGFA, DPYSL2, PRNP, ESR1, PPARG, RELN, HMOX1, ACHE, CST3, MAOB, TNF, MTHFR, IGF1, CD33, TFAM, IL6, CYP2D6, CRH, SOD2, UNC5C, PLCG2, TF, ABI3, WWOX, SLC30A6, CHRNB2, ARC, PGRMC1, F2, CALM1, EIF2S1, HLA-DRB5, ENO1, TPI1, IGF2R, SLC30A4, MIR296, SLC2A4, MIR100, IQCK, MIR375, AMFR, SNAR-I, ADAMTS1, MAPK14, PIN1, PYY, PTGS2, S100B, PPARGC1A, NOS2, NGFR, NGF, NFE2L2, SOD1, SYP, CDK5, NGB, MIR505, GAPDHS, MME, MAP2, CTNNB1, TPP1, LRP1, IRS1, CHAT, GAPDH, MIR4467, MIR3622B, AGER, MIR766, MIR708, CAV1, NTRK2, PTGS1, APLP2, ADAM17, MFN2, DNM1, HSF1, GSR, IL33, CCR5, HSPD1, HSPB1, CIB1, CASP8, IKBKB, SERPINF1, ATP7A, MT2A, ADAM9, INS-IGF2, BCL2L2, CASP9, GAB2, PTK2B, PLCB1, ABCA1, GRN, CASP12, SQSTM1, FERMT2, HLA-DRB1, NFIC, CSF1R, APOB, MARK4, HSPG2, MS4A6A, CELF1, VCP, SYNJ1, ZCWPW1, MS4A4E, APH1B, APOC2, F13A1, EXOC3L2, PLXNA4, ADAMTS4, AKAP9, MADD, DST, PILRA, FRMD4A, LAMP1, SLC24A4, GLIS3, SPON1, CADPS2, IL34, COL18A1, TRIP4, SPI1, TGFB2, BCL3, MTHFD1L, AICDA, IL6R, DCHS2, MEGF10, SLC16A7, EPHX2, NDUFAF6, DSG2, OSBPL6, CELF2, UBE2L3, SPPL2A, MAPK7, CDH13, LAMA1, SGK1, SUCLG2, LUZP2, PTPRG, ST6GAL1, AP2A2, RBFOX1, SORCS3, TSPOAP1-AS1, TLN2, ZAP70, ALDH1A2, TCF7L2, FMN2, OTOF, EXOC4, HSD17B10, DNM1L, ALOX5, GULOP, HTR2A, AHCYL1, SDR42E2, HTR6, GTF2H1, GRM5, IAPP, AHSA1, STAG3, ALB, FARP1, TSHZ1, HRES1, AGFG2, DCAF7, SIGMAR1, BCKDK, RTN3, TPPP, HSPA4, HCLS1, HSP90AA1, G3BP1, PGAM5P1, BACE1-AS, KHDRBS1, ALDH2, CFH, HCRT, GPC6, ABCA8, GLP1R, NR3C1, TNRC6A, IL19, PARVB, DDX25, BZW2, FCN2, FGF10, GOLIM4, LINC00476, HPGDS, FANCD2, PDE7B, SIGLEC7, TSPAN16, TRPC4AP, POLDIP2, CNTNAP2, RNF19A, BACE2, UBQLN1, ITSN2, GRIN2B, ZGLP1, BCAS3, EPDR1, TMED9, ENO2, CYCS, ANXA1, EPHB2, EPO, RAPGEF6, APH1A, LARS1, EYA4, SNX9, ESR2, WAC, SLC8A1-AS1, DCTN4, RMDN1, QPCT, MTOR, SGK3, FBXL7, SZT2, GIP, ACSL6, WWC1, CLEC16A, KAZN, LINC01672, PRRC2C, COLGALT2, PLD3, HECW1, ZNF292, MYO16, DKK1, SIRT2, ACOT7, PSIP1, CLASRP, LINC00271, SIRT3, SIRT1, GFAP, NUP62, FYN, CBLC, INHCAP, TRIM51CP, GABPA, GABRA2, GABRG3, DAPK2, SMUG1, GAP43, GATA1, GCG, GCHFR, TARDBP, NCS1, GDNF, HDAC6, RAB3D, MVP, OGG1, LINC02268, LINC02325, SOAT1, ACTG2, ACTG1, SNCG, SNCA, SNCB, SNAP25, NOS1, ACTB, MEF2C-AS1, SLC6A4, NPC1, SLC6A3, GEMIN7-AS1, SLC1A2, LINC01508, LINC01725, NEFL, COX2, TNFRSF1B, STAG3L5P, TLR4, TLR2, MSH2, THY1, MT3, TH, SST, STAG3L5P-PVRIG2P-PILRB, TGFB1, TFF1, RNR2, LINC02653, LINC01712, TCF3, NRGN, CX3CL1, ELMO1, CCL2, PIK3CG, ABCA2, PLA2G1B, EIF2AK2, SERPINA3, PLG, MAPK8, MAPK1, PRKCB, PRKCA, PRKAB1, PRKAA2, PRKAA1, PMS2P1, POLD1, PTPA, PON1, PIK3CD, PIK3CB, PIK3CA, MOK, UPK3B, SORT1, ROS1, SERPINE1, REST, REN, RELB, RAC1, LINC01965, PVR, PVALB, PTPRA, LINC00972, ABCB1, LINC02008, MTCO2P12, TP53, OVCH1-AS1, MOBP, MNAT1, SLC4A8, AGT, INSIG1, AZIN1-AS1, EIF3E, FHL5, IRF2, GSTO1, ITM2B, GRAP2, LIPG, ADIPOQ, KL, MSC, LRAT, AP4M1, CCRL2, IL18, IL17A, IL12A, ST18, IFNG, ARL17B, AKT1, AIF1, KRBOX1, IGFALS, HDAC9, PHF14, IL10, IL1A, ALOX12-AS1, MICAL2, IL2RB, IL4, CLOCK, CXCL8, KCNN2, MPZL1, HERC2, VDR, TFEB, MAOA, COX10-AS1, ZNF232, YWHAZ, VLDLR, PARP1, UTRN, BCAM, UCHL1, UBB, TYROBP, AFF1, TTR, TRPM1, MMP9, AIMP2, LTBP2, KNG1, CRADD, CACNA1G, LAMC2, RPSA, CDK5R1, SUCLA2, LCN2, LDLR, BECN1, LPL, PDE5A, ABCB11, APOC4-APOC2, KHSRP, DENR, AGPS, LPA, CDKAL1, PPARA, MEIKIN, COL4A4, CRK, CEACAM22P, SCIMP, CREB1, CR1L, ZNF862, SH2D4B, CP, PNPLA7, SIMC1, GGACT, COMT, COL12A1, FAM181A, BRCA2, PPP1R37, GPR141, TENM3-AS1, CNR2, L3MBTL4, UBXN11, ACKR2, TMEM132C, CASTOR3, CLPTM1, STRADA, FNIP1, CDCA5, NLRP3, APOA1, CRMP1, KAT8, CSMD1, CLMN, PINK1, CYP8B1, AHNAK, MIR132, MIR107, CUX1, POTEM, PPP1R3B, FAS, SAP30L, ANKRD55, CTSD, CTSB, GEMIN7, EHMT1, LINC01184, CTNNA2, LINC01185, TMC5, THSD4, CCDC134, SP6, LINC01567, PDCD1LG2, SETD7, APOD, BHMG1, CSF2, HYI, BLOC1S3, TSPO, CHRNA4, CHRNA2, TAS2R62P, C3orf67, C9orf72, CCDC83, CCDC89, KDM1B, CD14, TGM6, ATXN7L1, RSPO4, ADGRF2, STH, TAS2R64P, CALHM1, RUNX1T1, PPP1R42, ALPK2, PCSK9, CAT, ANKRD31, CASP6, NKAIN3, TRIQK, CALB1, STEAP1B, CASP1, EPHA1-AS1, CAPN1, APOC4, FAM181A-AS1, NKPD1, SPRED2, CD36, SCARB1, PLPP4, MED12L, ARAP2, CHN2, CHI3L1, ACTBL2, C10orf71, MCIDAS, LRRK2, AKR1C4, ANO4, AGBL1, CEACAM20, ZNF813, RMDN3, CETP, CDR1, LINC00343, TCAM1P, APOC1P1, IGSF23, RMDN2, CDK1, SLC25A48, NKAIN2, FSIP1, CD68, BMPER, C3, CD40, CYP19A1, CRP, NIT2, ANO3, DLG4, ARHGAP20, RCAN1, WDR41, NDUFA12, STK32B, EDEM2, DSCAML1, RNF165, SH3RF1, DYRK1A, MIR29A, SYBU, AQP4, APBB1, DLX5, DBN1, PALM2AKAP2, CEACAM19, DPP4, IL6-AS1, ARVCF, CDC42SE2, DMXL1, TULP4, DAPK1, PMS2CL, POTEKP, MIR34A, VAT1L, OLR1, HDAC2, LRP8, GSN, CCL11, S100A9, COL25A1, POTEF, KLK6, BLMH, HSD17B7, P2RX7, COX8A, ABCB6, PRRT2, IL2, SORCS1, NR1I2, MAPK3, ITGAM, CASR, ATP7B, VDAC1, EGR1, PDE4A, RAB5A, SUMO1, NRG1, OXER1, NTRK1, TFCP2, ANK1, CSNK1D, DLST, APLP1, BLVRA, NFIB, IL1RN, HTT, ACAT1, PLA2G4A, NFIX, NLRP1, GPRC6A, HMGCR, PPID, LPAR3, FZD4, REG1A, MRGPRX1, LRP2, DBH, PSENEN, VPS35, ESCO1, HSD11B1, VN1R17P, SOX2, AGTR1, XBP1, MIR155, MRGPRX4, MRGPRX3, GAL, GPR151, IL13, PAEP, OGDH, GPR166P, STAT3, SET, NFIA, PLB1, AR, LGR6, DHRS11, ABCG2, C4A, KCNIP3, HSD17B13, ABCG1, TTBK1, NOTCH1, EIF2AK3, SLCO6A1, CHMP2B, RBM45, CD44, RIPK1, APBA1, GSTK1, ADNP, ICAM1, BRCA1, APCS, TNFRSF1A, NFKB1, CNTF, MMP3, KLC1, LBP, CTNNA3, SGSM3, FGF2, C4B, HIF1A, CREBBP, SERPINA1, TMEM106B, GRIA1, GRIA2, ECE1, C4B_2, GSAP, OGA, TFRC, PLA2G6, ST3GAL4, PAWR, MFAP1, KAT5, GSTM1, APRT, COX1, HP, NTF3, MIR206, FPR2, CDC42, FUS, MARK1, FGF1, PREP, C5AR1, PON2, MIR29C, CALB2, PDIK1L, SYK, S100A1, CH25H, SREBF2, COX5A, GRIN2A, VCAM1, TMED10, GSTP1, KLK8, PHF1, CXCL10, MEFV, SP1, GJA1, IGFBP3, SLC17A7, CYP3A4, FOXO3, HMGA1, SLC11A2, XPR1, MARK2, PPIF, CRHR1, SHANK3, MYC, CD40LG, CPOX, FKBP5, ANPEP, CAST, C1D, FKBP4, HSPA1A, FLT1, MIF, PLA2G2A, CX3CR1, CSF3, IFNB1, KALRN, PLTP, STXBP3, DDR1, PWAR1, PRDX2, TP63, VIM, IL23A, F2RL3, MMP14, MEF2C, TREM1, TMED10P1, NAT2, MIR342, SAMD9, RAB7A, PGR-AS1, TRPM2, EGFR, ADRB2, CLDN5, ETS2, SYT1, TIMP1, NME8, ELANE, F2R, CD59, EPHA4, CBS, MSMB, APLN, MMP2, MYCL, CALML5, SYN1, XRCC1, TGM2, EEF2, PLA2G7, ELAVL2, EDN1, TMEM97, HMGB1, MIR455, HTRA1, BPIFA2, SLC52A2, NQO1, TUBA1B, FOS, CRYAB, SLC2A1, GPR3, LGMN, SLC2A3, RIDA, FN1, ABCA4, HSPA1B, PECAM1, PTEN, HSPA8, HLA-A, PTPN1, HAMP, TXNIP, GRM2, P4HB, LIN28A, PSPH, GSTT1, CCN2, DECR1, CPLX1, BCYRN1, NES, POU5F1P4, MIR21, GRK5, POU5F1, NTSR1, MIR212, PRKN, LINC02210-CRHR1, HSPA5, DLD, DAB1, HTRA2, POU5F1P3, MIR137, DNAH8, MAPK10, GH1, SERPING1, ADAMTS2, EEF2K, GSTO2, ROCK2, NEDD9, SPTBN1, NTN1, CEBPD, GDF2, CEBPB, PWAR4, SYNM, IGFBP2, GLUL, ABCC9, ATM, PSPN, PTPRC, MIR29B1, RANBP9, NDRG2, CNR1, RTN4R, PTBP1, AQP1, PDK1, MIR106B, PDE4D, ARNTL, PRDX1, ADM, RENBP, POMC, PTPN4, MS, PDGFRB, P2RY2, MIR142, PDE9A, SSTR4, KLK3, BCL2A1, C2, SRPK2, NFATC2, ADCYAP1, LRRTM3, PLD1, NUBP1, MIR424, ATF4, BSG, MIR29B2, PPY, BMP4, TBP, SLC18A3, POLB, NOTCH3, SLC18A2, NPTX2, MTR, SI, MIR222, SH3GL2, ND2, NR4A2, SELENOP, CXCL12, CCL5, ATXN1, CALM3, ITGAX, IFNA13, DISC1, OPTN, HTR1F, HTR4, WNT3A, COL11A2, C20orf181, IFNA1, KEAP1, HDAC4, KLK4, SEMA6A, LRRC4, CRTC1, IL9, DAO, ALOX15, AGTR2, IDO1, SLC25A27, ABCG4, CD55, APOA4, MCOLN1, REM1, ATCAY, EBPL, HSPB2, HSPA9, PLK2, GAD1, NANOG, DCX, COASY, UBE2K, DDIT3, TREML2, APBB2, MAP1LC3B, SRRM2, GZMB, FXN, HNRNPA1, HPSE, RAB10, CIP2A, FOLH1, STIM2, DIO2, MMP24, CEBPZ, GBA, CDR2, ITPR3, CDKN2A, MELTF, SLC30A3, ADRA2B, FTO, FNDC5, GGA3, XPNPEP1, VGF, NR1H2, UGCG, MFGE8, MGAT3, CXCR4, TLR9, APOC3, GPT, ELK3, NEAT1, ADORA2A, MMEL1, TRPC6, EIF4E, CAMK2A, MS4A6E, SRR, HSPA14, IRS2, MGAM, C1orf52, HDAC3, PABPC4, ACKR3, LGALS3, FAM20C, WNK1, DRD4, CYP2C9, MBTPS1, DRD1, LRP6, GRK2, CYP2B6, OGT, LIPA, AD11, GORASP1, PTGDS, SPEN, MIR200B, NPTXR, DNMBP, MIR200A, NCOA6, MIR181C, RBP4, RELA, OPN1LW, EFHD2, MIR188, TPH1, HNRNPA1P10, CTNNBL1, SLC40A1, PNO1, CHCHD2, SDF4, RETN, GOLM1, PPP3R1, PYCARD, PAG1, CCR2, DDIT4, RCBTB1, SBNO1, PPARD, CD274, PCBP4, ACE2, PROS1, PRND, PPP1R15A, CIZ1, MIR26B, TPSG1, GGA1, CFAP97, MAP2K1, AATF, SHANK2, PRL, RBMS3, LOC107987479, MAP2K2, PAXIP1, CHCHD10, SBNO2, PTGES, SPHK1, LPAR2, PPIG, NRXN3, MED23, SPP1, MAPK8IP1, BAG3, APBA3, TAP2, PRDX6, CARTPT, SNAP91, SV2A, MALAT1, MAK16, SYVN1, GDF11, TAC1, TAT, SLC6A2, TRPV1, CISD3, TPT1, TSC2, TM7SF2, TXN, UBE2I, TLE1, TIMP2, XK, CNTN2, TGFBR2, YY1, GOLGA6A, ANP32A, TAM, TERT, DCP1B, TNFSF10, PPP1R1B, GPHN, RGS2, ADAM30, SAA1, METAP2, IMMT, SDS, ADAP1, RYR3, ECHDC3, RYR2, RXRA, SCD, RPS6KB1, CIT, RPS6, CTXN3, LMTK2, NLGN1, ROCK1, RGS4, ATXN2, SRL, STUB1, SHBG, LILRB2, AKR1A1, OLFM1, SKIL, SLC9A6, CREB3, PITRM1, SCGN, CXCR6, OCM, RIN3, SGCA, SFPQ, NCKAP1, CPLX2, TP73, EDAR, CCL3, NPS, BEST1, HPS1, CXCL1, GLO1, LIF, CDH1, LHCGR, CDK4, PCNA, PCK1, L1CAM, GPR42, GPX1, GRB2, ANGPT1, ANGPT2, CETN1, MYD88, GLB1, AKT2, LMNA, DNMT3B, TSC22D3, CD38, PER1, CD69, DRD3, LOX, CD74, LMNB1, DNM2, GAS6, AVP, GC, DMRT1, SARDH, GRIN1, ANXA5, BACH1, P2RY1, INPPL1, CSF1, CS, NEFM, NTS, APEX1, STS, HTC2, NEUROD1, NPTX1, NPPA, ATF2, HTR2C, ARRB2, IGFBP7, HMGCS2, CLK1, CKB, APBA2, CYP17A1, GSTM3, CHGA, CYBB, JUN, CTSS, ORM1, ITPR1, CHRM1, CHRM2, OPRK1, OPRD1, CTRL, HK1, ADRB1, LAMP2, CASP2, EDNRA, PLD2, CAPN2, F2RL1, ACO1, ERBB4, FAT1, FGFR3, CALM2, BRS3, CALCA, CAD, EGF, CASP4, FCGR3B, FDPS, LYZ, FCGR3A, FLNA, MECP2, FABP3, ADRA1A, PLXNA2, MBP, FAAH, ENPEP, F12, BAG1, MEOX2, HOMER1, ITGB2, DBA2, ITGAL, ITGB1, AIM2, AZIN2, CD80, ITIH4, CD46, VIP, CHRNA3, ATG5, TREML1, MCL1, GPRASP2, VWF, APOA5, TMEM119, KLF4, SOCS6, WNT1, XBP1P1, FOXQ1, C3AR1, OPN4, USF1, C1QA, CXCR2, VPS26A, MOGAT3, CCR3, IL6ST, IL5, IL1RAP, LMF2, IL1R1, CREB3L1, UNG, MCU, CLSTN3, SNPH, IL9R, NPEPPS, NAPSA, USF2, MEF2A, ING1, CGB8, FTMT, CHM, VAV1, IMPA1, C1R, ILK, ADAMTS3, IL16, MAP3K5, IL15, GDF15, CGB5, CA2, KCNB1, TSPOAP1, SMAD2, DPPA2, SGO1, LIG3, IFNL3, TNK1, CP20, APCDD1, HSD17B6, CDKN1A, TTBK2, CDKN1B, SLC2A14, CFLAR, STMN1, LIPC, TAB3, CHIT1, BRAP, SPARCL1, MLKL, PTCRA, CD47, LGR5, CD8A, CCT, NR4A3, USP9X, MSRB3, CDR3, CCK, LNPEP, CASP7, CHRFAM7A, CAMP, PER3, YES1, CGA, MARK3, CGB3, SYNGR1, CALCR, IL1RL1, ARHGEF2, PER2, SLC33A1, TPH2, CHEK1, RAB7B, NOG, MBL2, CFL2, HSPB6, AHSA2P, SLC30A1, CD200R1, SOCS3, KDR, KIF5A, HAP1, CALR, CES1, TRPA1, HSPB3, WASF1, SLC32A1, ARHGEF7, CAMK4, COL3A1, H3P40, SCRN1, PTCD1, SPHK2, ATN1, PPIL2, POU2F1, FOSB, GCA, FLT4, SH2B1, APPL1, DNMT1, FLG, FOXO1, DUSP1, DUSP6, HHAT, HSPB8, E2F1, PLXNA3, DOCK2, PNPLA2, ADI1, GMFB, GPI, GPC1, KIF21B, NMNAT2, TRIB3, ALS2, DLG2, DLG3, GLS, PDSS2, ASTN2, MCF2L, GLI2, KIDINS220, CBLIF, SYNE1, DMD, GGT1, FKBP1A, SIT1, SV2C, GDE1, FOXP3, ASCC1, TMED7, FIS1, PRLH, CRYL1, ADIPOR1, LSR, F11, MBL3P, SIRT6, TRMO, NRN1, LCMT1, PRRX2, ERN1, BIN2, UBR5, HEBP1, GEMIN4, PDCD4, TBK1, SLC25A38, FGF14, PCSK1N, TRPM7, DLL1, FLVCR1, AHI1, SETD2, ELK1, IL22, NCAPH2, ELN, PADI1, BPTF, NRBF2, FABP5, EP300, PLA2G3, GRHL3, CXCR3, NAV3, SIRPB1, FLOT1, MET, KCNMB2, CRISPLD2, ARHGAP24, HNMT, SNX27, NPL, BHLHB9, TRIM13, HMOX2, KLF2, CSNK1E, LPAL2, CPQ, PPP1R2C, RAPGEF3, TET1, CRYZ, SORBS3, CTBP1, BCL2L11, COL17A1, NCAPD2, COX10, UBASH3B, NR1I3, ACOT8, PTPN5, PPP1R9B, TOM1, MINDY4, CPE, HTR7, NR1H3, HTR1B, HTR1A, LRPPRC, PDIA6, RHBDD1, NAA25, HLA-C, TPX2, BCAN, ADAMTS13, MOAP1, TNMD, GRIA3, NEUROD6, CHEK2, PADI2, HRH3, PHB2, SIL1, MGLL, FFAR1, GADD45A, MMRN1, DEFA1, IL21, NLRC4, GPR17, AZI2, HHIP, CTF1, HCRTR2, HLA-B, CTNND2, HHEX, HGF, CTSG, HDAC1, CTCF, DHX40, PTGES3, STIP1, CTSZ, CXADR, CARD14, CYP1A2, PDE10A, LILRB1, EHMT2, PDIA2, UMOD, ANGPT4, MIR339, SYN2, MSD, ACP3, APEH, ST8SIA1, AZU1, PI4KA, NCAM1, MIR144, SMIM10L2B, MSI1, NAP1L1, PRSS3, PEBP1, MASP1, SIM2, TIA1, MIR15B, ATD, RPL29, ABCC1, NCAM2, MIR125A, TLR5, SERPINF2, TNFAIP1, CXADRP1, MAPK9, ZFHX3, GGTLC4P, AD10, SGCG, MIR451A, CDR1-AS, TPTEP2-CSNK1E, MIR384, ITSN1, CBSL, MPZ, NFATC4, PKM, NCL, NTF4, LOC643387, SLC1A3, APOA2, THAS, PSMB6, SERPINB6, PSMB9, RHOA, ARMCX5-GPRASP2, SMPD1, REG3A, ATP4A, MIR193B, RFC1, NOTCH4, SLPI, PGF, AEBP1, MIR214, MIR219A1, SLC19A1, MIR22, PCSK1, ALPP, AMD1, MTNR1A, TGFBR1, COX3, ATP12A, NM, ADD3, PSD, TGM1, ARR3, NPM1, PAK1, TMED7-TICAM2, PNP, MIR195, MTHFD1, ADH1B, AMPH, ND4, AMD1P2, ARG1, SULT2A1, RRAS, PDE7A, TTPA, TYK2, TXNRD1, PPP1R1A, PPP1R10, SPG7, SPAST, RAB4A, PPP2CA, OTC, PPP2R2B, MMP1, ARMS2, RAB3A, GGTLC3, RTL1, P2RX4, ST13, SPARC, ALAS1, PPP3CA, NEFH, SEL1L, TYR, RAB6A, MICB, PPIA, CCL4, BST1, TICAM2, BNIP3, MIR326, OPRL1, PON3, BMP6, OPRM1, AHSG, H3P17, SDC2, AGRN, TYRP1, PPP1CA, BMI1, TYRO3, PNMT, DEFA1B, GGT2, ORI6, SMIM10L2A, CISD2, ARSA, EIF2AK4, PRKAR1A, LRP1-AS, SRSF2, MIR98, MIRLET7B, CD200, PDCD1, RAP1A, GGTLC5P, CCND1, ANXA6, FXYD1, S100A6, NFATC3, PLK1, ABO, PTGER3, APC, S100A12, ASL, HSP90B2P, SETMAR, PRRX1, PZP, STAT1, ODC1, CFB, CDNF, ZBTB4, PARK16, SUGP1, DIO1, SORCS2, MAGEE1, ALDH1A1, MIR1306, DES, DIAPH1, LSM2, MIR1229, XPO5, HCN3, CFD, MIR664A, KIF17, WDR48, MTRNR2L12, PRX, DHFR, EPG5, SEPTIN1, FAS-AS1, RNF213, MIR320E, MIR1908, HECW2, LINC00672, NUFIP2, ABCD1, DLG1, QRFP, ZNF410, AOC2, NBEAL1, CYP11A1, OPN1MW2, AD6, P2RY12, NMNAT1, DEPTOR, TNS3, CYP2D7, FAM72A, NUCKS1, CLEC7A, CYP26A1, ARAP3, GREM2, CDKN2B-AS1, CYP2J2, UBE2Z, MIR1246, TSPY3, MIR632, CTSK, GTDC1, CTSL, MIR650, MIR660, SNORD118, TNFAIP8L2, LYNX1, MUL1, PAGR1, CYLD, MAPKAP1, APOF, PDCL3, CYP2C19, NOC3L, CYP27A1, DPEP2, MFT2, PROK2, HPSE2, AD14, AKR1C2, ALPI, TRPV4, NTN4, PRM3, PDF, JAM2, ALOX5AP, TSPY10, DEFB4A, DEFB4B, ALOX12, PTBP2, DCN, NECAB3, FKBPL, NEUROG2, DGKQ, SLC25A4, MIR873, MIR301B, CENPK, DAXX, GFRA4, GOLPH3, ERVK-6, MTUS1, DBI, MIR937, ANG, ACE3P, SOD2-OT1, ANK3, DRD2, ZNF608, NAT10, DYM, LOC102724334, TRIT1, EIF4G2, TET2, EIF5, SERPINB1, ELAVL4, PDP1, ACO2, THRA1/BTR, UGT1A1, CCHCR1, CPVL, SMOX, TOLLIP, TERF2IP, SNTG1, EMP1, LOC102723407, EIF4EBP1, MIR6845, EIF2S3, ADCY2, NUDT11, EGR2, MSTO1, ADARB1, SLC6A15, ADA, TAPBPL, TESC, MIR6840, ACVRL1, FOCAD, EIF4A1, CASZ1, QRICH1, PGPEP1, EIF4A2, NDE1, ASIC2, CTTN, ACADVL, GSKIP, LNCRNA-ATB, ATP6V1H, H3P7, TDP2, ERBB2, CINP, ZCCHC17, H3P13, DTL, GPRC5B, ERCC1, DCDC2, NAT8B, GULP1, H3P23, ERG, H3P28, H3P11, PPIL1, STIN2-VNTR, NANS, EPHA8, H2BS1, POLE3, ACACA, SLC29A1, FXYD6, LRP1B, CST12P, SIRT1-AS, INPP5K, MSRB1, ARID4B, EPOR, ABL1, AAVS1, NR2F6, ERVK-32, LOC110366354, MNS16A, EFNA5, SLC47A1, ALAD, EEF1A1, SNHG19, MICA, DNTT, SOX21-AS1, DOCK3, DPYSL3, MIR626, XAB2, MFF, DUSP22, ARNTL2, SPPL2B, MCCC1, TMX2-CTNND1, ANKS1B, DPYSL5, FXYD6-FXYD2, BARHL1, DSC1, TWSG1, TLE5, DNASE1, DNA2, OCLN, NLN, AMIGO1, AHR, PLEKHG5, SLC24A3, SPC25, TTC7A, PELI1, JAG1, TMEM159, RTN4, APMAP, CD177, CAMK1D, PLAAT1, NR0B1, TIGAR, P2RX5-TAX1BP3, PARD3, GKN1, ADH6, INAVA, CDK5RAP2, OGDHL, LINC01080, ATF7IP, IPO9, VAC14, DVL1, PPP4R3A, OPN1MW3, EBM, OTUB1, SOX6, SLC30A10, SMPD3, MEG3, PLIN2, FBXW7, TDP1, ADORA1, DSC3, ACSS2, BTNL2, KIAA1217, ZNF253, CFC1, MIR4668, DSG1, APOM, MYO5C, MIR4487, NOTCH2NLC, USE1, SELENOS, GDNF-AS1, DSPP, ADCY10, ADRA2A, ZNF415, LINC-ROR, NARS2, CSF2RB, MIR616, MIR20A, CDC25C, PROM2, ATP6V1E1, IL23R, GLIS1, PM20D1, PHF13, CDH2, ZNF569, MIR191, CDK9, MIR192, PRIMA1, CDKN2D, MIR196A1, OR2AG1, LAYN, PIWIL4, MIR19B1, GPBAR1, CDC25B, GDF7, ZDHHC15, MIR139, CD63, SGMS2, MIR140, TMPRSS6, RHBDL3, AVPR2, MIR15A, CBLL2, MIR186, PRUNE2, AMOTL1, CD81, MIR18A, SLC2A12, CDA, MIR181A2, ATP5PO, SESN3, ATP6V1B2, UBR1, ATP5PF, PPME1, MIR224, LYZL4, KCNH8, MTERF4, MIR23A, CPO, ACMSD, MIR23B, BHLHE23, MIR25, CFL1, OSCAR, SPNS2, SEZ6, SLC38A10, MSI2, CFTR, MIR27A, MIR223, ALDH7A1, MIR221, SELENOM, ATP5MC2, CACUL1, HECTD2, SREK1, CTCFL, CBLN4, CDSN, ATP5MC1, DEFB104A, OCIAD2, MAGEC3, MIR210, CEACAM5, CECR, PPARGC1B, ATP5F1B, IL31RA, GNPDA2, SCARB2, NSMCE1, SOCS4, UBE2L1, BNC1, CACNA1C, SLC25A20, SERPINA13P, BLM, SREK1IP1, MIF-AS1, C20orf203, SYPL2, ZNF763, CCL4L1, BID, BGN, ZSCAN1, ZADH2, SMIM20, MILR1, PGP, GOLGA6L2, TMEM189-UBE2V1, TMEM189, IL31, C4BPA, BTK, AMIGO2, HCN1, NHLRC2, ATP9B, SBSN, BMP1, OSTN, C5, CFAP410, BARHL2, NANOS3, C9, STING1, GADL1, ARMH1, VPS51, HCAR2, CAPG, LINC00639, TMEM201, LIN28B, CD5L, MIR127, CD19, KIF6, MS4A1, MS4A3, HYLS1, STOX1, FOLH1B, OR8J1, TRIML2, CD28, KHDRBS2, GAPT, CENPV, KLHDC8B, MIR134, CD86, PIKFYVE, SLC29A4, CCNC, KRIT1, PTF1A, DAOA-AS1, BDKRB2, HCA1, BRD3OS, ASPM, BCS1L, SGMS1, BCR, MIRLET7D, MIR122, RUNX1, ANKK1, BCL6, PHYHD1, BAK1, MIR10A, EBF3, CCKAR, MIR28, FRMD6, MIR613, ADAMTS10, TMEM175, XIAP, MAF1, BIRC3, SLA2, ANTXR1, ASCC2, CRHBP, EVA1A, QRFPR, MAGT1, NCALD, LOC646506, ROPN1L, L3MBTL2, GMNC, SCFV, CSE1L, RNF146, PHF6, HOOK3, BRSK1, MBOAT4, COX15, MIR497, MFSD2A, MIR501, ACCS, ARG2, FAM126A, CPB1, CPN1, ECSCR, MAP1LC3A, MIR484, AQP9, CPS1, SNORD35B, CPT1A, ABLIM2, FASLG, NETO1, DOCK8, RNFT2, C1QBP, TM2D3, ASRGL1, PTGES2, PANK2, MIR590, SCD5, CSNK2A1, VCAN, ZC3H14, CSPG4, CTBS, MIR592, MIR598, CAMKMT, CTNS, SLTM, PTCD2, CTNND1, MIR603, NUBPL, WDR26, SPHKAP, GSTT2B, TMEM163, NCF1, LBH, SPAG11A, SFTPA1, CSF3R, ZNF436, CSN2, NDFIP1, MIR545, SLC44A4, SLC19A3, FAM72B, AIRE, IQCJ, CSNK1G2, DNAJC5, CSNK1G3, LINGO1, ATG4C, ATP2B4, MIR346, SERPINC1, CISH, ASPA, CLC, UCN3, TMEM54, ASS1P1, CLCN3, NACC1, ASIP, STX1B, IFT43, MIR133B, MIR151A, CLK2, TP53INP1, MIR330, MIR335, MIR338, MIR93, SLC26A7, OMA1, CHGB, PLD4, TDRD9, CHD1, MIR299, ATIC, ATHS, H4-16, LRIG3, EXOSC6, CHRM3, MIR30B, MIR30E, AGAP2, MIR31, MIR34C, MIR9-1, GRIN3B, GRIN3A, ASAH1, MIR369, H2BC12, KPRP, LRSAM1, MIR429, H4C15, SHF, GADD45GIP1, COL11A1, ZNF628, MIR431, HNP1, NAV2, MIR409, SLC31A1, RPPH1, SNORD14E, SNORD14D, SNORD14C, SNORD14B, COX6B1, MIR485, CNTN1, DNM1P33, CNTFR, CHRDL1, CLN3, MIR361, MYOCD, PRDM6, DNER, SPECC1, MIR377, CLN5, EXOC3L4, CNP, MIR425, ARRB1, ZNF804A, BDNF-AS, NLRP12, CCR6, ABCC2, DEFB104B, LRRC15, POU3F4, HOOK1, TERC, NAT1, MCM2, EZR, MDH1, VEGFC, MDH2, MDM4, MEF2D, UVRAG, UROD, UQCRC1, UGT1A, SLC35A2, UCP2, UBTF, UBP1, MID1, UBE3A, UBE2V1, CXCL9, ATXN3, UBE2D2, UBE2A, UBC, MAP3K10, MC1R, WARS1, WAS, ZMYM2, MANF, SCG2, FZD5, SMAD7, MAG, MAP3K12, MAP1A, MAP1B, ZNF236, ZNF224, ZNF217, RNF112, WEE1, MZF1, ZIC1, MARS1, MAS1, MAT1A, MAT2A, MAZ, XIST, WT1, WNT2B, WNT5A, UBA52, KMT2A, MLLT3, THBS1, TLR3, TLE3, MSH3, TKT, TIMP4, TIMP3, MSR1, MSRA, THRA, THOP1, THBS4, CYTB, MRE11, NUDT1, TGFBI, TGFB3, ND1, TFF3, TFDP1, MTNR1B, MTRR, TRNL1, MUC1, TERF2, TSPAN7, MRC1, TWIST1, TRAF2, TUBA4A, NR3C2, TTN, TSPY1, TSHR, TSG101, TSC1, MMP7, MMP8, TRPC1, TRH, NR2C2, TNFAIP6, MMP13, TPM1, MOG, MOV10, TP53BP2, TP53BP1, MPG, TNR, TNNI3, MPI, MPST, SLBP, REEP5, DEK, SNX3, TNFRSF6B, RAB11A, LDHA, LEPR, LGALS4, LGALS9, GPAA1, RNMT, GBF1, ADAM19, URI1, TRADD, LCK, B3GALT4, LIFR, LIG1, SOCS1, NUMB, LIMS1, AOC3, PDE8B, USO1, TNFSF11, STK16, LCT, CES2, KMO, KLRC1, BRSK2, KCNQ1, KIR2DL2, NOL3, ATP6V0E1, SELENBP1, USP13, KLKB1, CDK5R2, RAB29, MBD2, KIF11, TMEM11, ENDOU, EIF2S2, TAX1BP1, NAE1, KRT14, KRT18, LAMC1, LBR, PROM1, LCAT, SOCS2, PRKRA, DEGS1, DDX39B, PABPN1, EOMES, BAP1, LTF, H4C9, COLQ, DYSF, CHAF1B, LYN, NRIP1, COIL, SLC7A5, AD5, H4C1, FGF23, ADAM12, BRD3, PSCA, ARHGEF5, TFPI2, FZD3, GHS, M6PR, MARCKS, SMAD1, LTC4S, H4C4, BHLHE40, IRS4, MAPKAPK5, LMO4, LOXL1, CST7, DDO, DGKZ, GAS7, PIK3R3, PKP4, PPFIA1, LRPAP1, SORBS2, H4C6, CUL4A, GNPAT, LTB, H4C14, H4C13, H4C5, H4C2, H4C8, H4C3, H4C11, H4C12, TERF1, MUC4, KCNMA1, TDO2, PCP4, CDK18, RBM3, RBL2, RBBP6, RB1, RASGRF1, RASA1, RARRES2, RAN, RAF1, RAD52, PCYT1A, RAD23B, RAC2, PDB1, RAB27B, RAB27A, PDC, PDE2A, PURA, PDGFB, ENPP2, PDYN, PTPN13, PC, PAX6, PARN, RPL15, P2RX1, S100A8, P2RX3, P2RX5, P2RY4, RREB1, RPS23, RPS21, RPS6KB2, P2RY6, RPS3A, RPL13, RET, RPA1, PAFAH1B2, RORA, ROM1, SNORD15A, BRD2, RNASE1, RHO, RHD, PAK3, TRIM27, PTPN11, PENK, PTN, PMM2, PLAUR, PLCL1, PLEK, PRKCE, PRKCD, PLP1, PRKAR1B, PRKACB, PRKACA, PLXNB1, PML, PRG2, PLAT, PMP22, PRB1, PPT1, PPP2R5E, POLG, PPP2R1A, PPP1CB, PPL, PPIC, PPIB, POR, MAP2K3, PLAG1, PFDN5, PSMD2, PFKFB3, PTGER2, PTGER1, PGD, PTGDR, PTCH1, PGR, PHB, PSMD9, PSMD7, PSMD3, PSMB2, PITX2, SERPINE2, SERPINI1, KLK10, PIK3C3, PIK3R1, KLK7, PIK3R2, PRS, PROS2P, PIN4, PROC, S100A10, OXT, OXA1L, SQLE, STAR, ST14, ST2, NDUFA6, SSTR3, SSTR2, NDUFA9, NDUFB8, SRM, SRF, NEDD4, SEPTIN2, STC1, SP4, NEU1, SOX5, SOX3, SOS2, SOS1, SOD3, NFE2L1, NFKB2, SNRPG, SNRNP70, NDUFA5, STIM1, NME1, MYH9, TRBV20OR9-2, TCP1, TCN2, MMUT, MUTYH, TCF4, ELOC, TBX2, MX1, MYH6, TARBP2, MAP3K7, STK11, MYO6, TACR2, NACA, VAMP2, VAMP1, SURF1, ABCC8, SUOX, NDP, STXBP1, STX1A, NINJ2, NME2, SAA2, OMP, SFTPC, TRA2B, SRSF6, SRSF5, SRSF3, SRSF1, SFRP1, OCA2, MAP2K4, ODF1, SELE, OPA1, OAS3, CXCL11, CCL21, CCL20, CCL19, CCL8, CCL1, SCP2, SCN1A, ORM2, OSM, TSPAN31, OAT, SGSH, SUMO2, SLC8A3, SMPD2, SLN, SLIT3, SLC22A5, SLC22A2, NQO2, SLC18A1, SLC16A1, SLC12A3, SLC11A1, SLC10A2, SLC8A1, NUP98, SLC6A12, NPHP1, SLC6A1, SLC5A2, NRCAM, NRDC, SLC1A1, NRF1, PMEL, YBX1, NT5E, NAT8, SEMA5A, ESRRA, RAB31, MACF1, HEY2, BRD4, TRAM1, CBX5, ANGPTL2, OPN1MW, GRIP1, KCNH4, MSTN, GFER, GFRA1, SIRT5, COTL1, GFRA3, GHR, ZNF629, UBR4, GHSR, WASHC4, GLI1, NUP160, CLUH, GLI3, SCFD1, KCTD2, CLCF1, SEC14L2, NR5A1, SLC24A2, PRPF6, TFIP11, MAFF, EID1, RAB38, FSHR, TMEFF2, PLA2G15, SLC7A11, FTH1, SNHG1, TSPAN15, GAST, ACKR1, G6PD, GAB1, NTSR2, GABBR1, GAD2, GALNS, DDAH1, PADI4, GART, NBEAL2, GMPR, PLEKHM2, WDHD1, GPR39, CARD8, ARHGEF15, AAK1, SYNPO, GPX4, ECD, PARK7, KLF8, TREX1, WIF1, WDR45, ATF6, CORO1A, TBC1D8, SLC7A9, GRIA4, FAF1, GRIK4, RER1, GRM1, STMN2, RAPGEF4, ADRM1, MSRB2, RAB3GAP1, GNA12, ZNF423, ATG4B, UBXN4, RCOR1, SEPTIN8, STAB1, GNAI1, MAPK8IP3, GRAMD4, GNB3, NFASC, KIF1B, GOLGA2, GPER1, SETX, GOLGA4, PDZD2, SAMD4A, KDM1A, GPM6A, RAB21, GPR6, P2RX2, GPR20, SNW1, FRK, FBXO7, BRI3, SNX12, SOCS7, CD209, FABP6, TBX21, NOP53, FABP7, SLC2A8, UBQLN2, A1CF, PSAT1, FANCG, HOOK2, DELEC1, FASN, SNX8, NPC1L1, BLNK, MS4A2, FCGR1A, FCGR2A, MYLIP, SCG3, DROSHA, TMEM230, NOX4, PCA3, SPCS1, VRK3, ETFA, SLC25A37, TLR8, SLC22A17, ECSIT, CD320, EZH2, DNAJC27, CLEC1B, NT5C3A, MZB1, F2RL2, HP1BP3, F3, F9, IRAK4, SAR1B, UTP11, F13B, SH3GLB1, SIDT2, SHANK1, TRAT1, F11R, RGCC, TMEM176B, NOCT, FBXO2, NPTN, TPK1, VCX, GREM1, FKBP1AP2, FKBP1AP3, AGO1, SEZ6L2, FKBP1AP4, FGF21, CLDN17, NOC2L, SND1, FOXM1, EPC2, ATRNL1, LRP10, FLNB, FMR1, POU2F3, TXN2, FBXL2, FOLR1, FOLR2, FKBP1AP1, B3GAT1, IGHV1-68, TNFRSF21, FEB1, FES, FGF9, RABGEF1, PRPF19, FGF13, FGFR1, FGFR4, PDLIM3, RND1, KLHL20, COQ2, CACYBP, HCAR1, FHL2, VPS4A, IL37, GLS2, NAAA, CYTH4, DKK2, DKK3, BBC3, SDCBP2, GRM3, IL24, SPAG9, CXCL2, PCLAF, IGFBP1, ACAP1, IGFBP5, SART3, KDM4A, IGHG3, SDC3, SH3PXD2A, RGS6, SNCAIP, TCL1B, IL4R, IL7, BCAR1, CCL4L2, CXCR1, BAG2, IL12B, BAG5, TMEM59, TBPL1, GAL3ST1, AKAP5, STX8, PIEZO1, BMS1, PTDSS1, IDH1, SH2D3C, GNE, SH2B3, IRF8, SRA1, TANK, KCNE3, HNRNPDL, CCS, NUP153, MED12, HS3ST1, TOMM20, RBM8A, IDH2, CFI, SV2B, TECPR2, IFI27, TOMM70, KIAA0319, IFIT3, IFNAR1, IGBP1, INSRR, PCYT1B, IL27RA, CCNE2, NOLC1, TIAF1, JUND, ZMYM3, KCNC4, KCNJ13, HGS, SYNGR3, ATG12, CBFA2T2, RABEP1, P2RX6, RAB11B, SLC16A3, SLC16A4, ATP6V0D1, RGN, USP10, USP2, USP14, DNAJA3, CLDN1, CLDN8, ARTN, JUNB, GPR50, PICK1, ITPKB, IRAK1, HOMER2, IREB2, IRF3, IRF6, IRF7, ITGAV, CYP7B1, ITGB3, NRXN1, SLC22A8, ITPR2, AIMP1, JAG2, ITGBL1, LHX2, SLIT2, TAOK2, CD163, JAK2, GPR37L1, PIWIL1, MAPKAPK2, PDLIM7, IARS1, TNC, IL18BP, CCT2, HCK, NRG3, USP39, DCTN6, CD226, HDC, HDLBP, CAMKK2, HIP1, TXNRD2, NPC2, SLC35A1, HBG2, PRDX4, ZNRD2, HYOU1, HLA-DQA1, SEMA4D, HLA-DQB1, NXF1, HLA-DRA, ATP5PD, COG5, GPNMB, CHL1, HAS3, FAM3C, GYPA, GSK3A, COPS5, GSM1, GSTM2, EBNA1BP2, PRSS21, PRDX3, GSTZ1, GTS, GUSB, C1QL1, GYPB, HAS1, GYPC, CCL27, ALDH1L1, GYPE, HAGH, WASF3, HSPH1, GJB6, HARS1, ARPP19, DHS, HLA-DRB4, HLA-G, PQBP1, MPHOSPH6, STAM2, GLYAT, HOXA@, RABEPK, HPCA, CALCOCO2, HRC, OLIG2, DDX39A, TOPORS, EIF1, HSD17B1, RAMP2, WASF2, HSD17B4, HSPA2, HSP90AB1, DNAJB1, NAMPT, BCAP31, CTDSP2, TSPAN3, ACTR2, CERT1, ABCC4, HNRNPK, HMBS, NPM3, CFDP1, PRMT5, HMGB2, YAP1, IFITM3, SPAG11B, PEMT, RACK1, SYCP2, TUBB4B, SEMA3A, WARS2, HNRNPC, FOXA1, CCL26, TLR6, FOXA2, LAMC3, LANCL1, HNF4A, TCIRG1, APBB3, APC2, HNRNPA2B1, MTCH2
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Av Nodal Reentrant Tachycardia
Wikipedia
Not to be confused with Atrioventricular reentrant tachycardia . AV-nodal reentrant tachycardia Other names Atrioventricular-nodal reentrant tachycardia An example of an ECG tracing typical of uncommon AV nodal reentrant tachycardia. ... The fast pathway is usually located just superior and posterior to the AV node. These pathways are formed from tissue that behaves very much like the AV node, and some authors regard them as part of the AV node. ... In AVNRT, the fast and slow pathways are located within the right atrium close to or within the AV node and exhibit electrophysiologic properties similar to AV nodal tissue. ... "Typical", "common", or "slow-fast" AVNRT uses the slow AV nodal pathway to conduct towards the ventricle (the anterograde limb of the circuit) and the fast AV nodal pathway to conduct to the atria (the retrograde limb). The re-entrant circuit can be reversed such that the fast AV nodal pathway is the anterograde limb and the slow AV nodal pathway is the retrograde limb, referred to as "atypical", "uncommon", or "fast-slow" AVNRT.
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Second-Degree Atrioventricular Block
Wikipedia
Second-degree atrioventricular block Other names Second-degree heart block ECGs demonstrating forms of second-degree AV block Specialty Cardiology Symptoms Dizziness , Fainting , Shortness of breath Types Type 1 (Wenckebach), Type 2 Causes Fibrosis in AV node, medication, vagal tone , electrolyte disturbances Diagnostic method Electrocardiogram Treatment Avoidance of AV-nodal-blocking medication, pacemaker Second-degree atrioventricular block (AV block) is a disease of the electrical conduction system of the heart . ... It is classified as a block of the AV node and is categorized in between first-degree (slowed conduction) and third degree blocks (complete block). ... Both types are named after Woldemar Mobitz . [3] [4] Type I is also named for Karel Frederik Wenckebach , [5] and type II is also named for John Hay . [6] [7] Type 1 (Mobitz I/Wenckebach) [ edit ] Type 1 Second-degree AV block , also known as Mobitz I or Wenckebach periodicity , is almost always a disease of the AV node . ... The definitive treatment for this form of AV Block is an implanted pacemaker . ... Thus one may leave out the type and refer to 3:1 Mobitz block or 4:3 Mobitz block, for example, without creating ambiguity, except in the case of 2:1 block. 2:1 AV block [ edit ] In the case of 2:1 block (2 P waves for every QRS complex) it is impossible to differentiate type I from type II Mobitz block based solely on the P:QRS ratio or on a pattern of lengthening PR intervals. [12] :182 In this case, a lengthened PR interval with a normal QRS width is most likely indicative of a type I-like pathology, and a normal PR interval with a widened QRS is most likely indicative of a type II-like pathology. [12] :182 See also [ edit ] Electrocardiogram (ECG or EKG) SA node AV node Atrioventricular block First-degree AV block Third-degree AV block References [ edit ] ^ "Lesson VI - ECG Conduction Abnormalities" .
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Ventricular Escape Beat
Wikipedia
Contents 1 Causes 2 Diagnosis 3 Management 3.1 Cilostazol 3.2 Ouabain 4 References Causes [ edit ] Ventricular escape beats occur when the rate of electrical discharge reaching the ventricles (normally initiated by the heart's sinoatrial node (SA node), transmitted to the atrioventricular node (AV node), and then further transmitted to the ventricles) falls below the base rate determined by the rate of Phase 4 spontaneous depolarisation of ventricular pacemaker cells. [1] An escape beat usually occurs 2–3 seconds after an electrical impulse has failed to reach the ventricles. [2] This phenomenon can be caused by the sinoatrial node (SA node) failing to initiate a beat, by a failure of the conductivity from the SA node to the atrioventricular node (AV node), or by atrioventricular block (especially third degree AV block ). Normally, the pacemaker cells of the sinoatrial node discharge at the highest frequency and are thus dominant over other cells with pacemaker activity. The AV node normally has the second fastest discharge rate. When the sinus rate falls below the discharge rate of the AV node, this becomes the dominant pacemaker, and the result is called a junctional escape beat . If the rate from both the SA and AV node fall below the discharge rate of ventricular pacemaker cells, a ventricular escape beat ensues. ... Ventricular pacemaker cells discharge at a slower rate than the SA or AV node. While the SA node typically initiates a rate of 70 beats per minute (BPM), the atrioventricular node (AV node) is usually only capable of generating a rhythm at 40-60 BPM or less.
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Atrial Septal Defect 7 With Or Without Atrioventricular Conduction Defects
OMIM
His mother had the same mutation and ASD with atrial fibrillation; her elder sister had ASD secundum with AV block and sick sinus syndrome requiring permanent pacemaker implantation, and a nephew had ASD with AV block. ... In 3 members of the other family (see 600584.0010), surgical closure of a secundum ASD had been performed; all 3 had ECG evidence of first- or second-degree AV block. In 1 member of the family, first-degree AV block was the only manifestation of heart disease. Hirayama-Yamada et al. (2005) reported that 4 sibs from a family with ASD and AV conduction defects had the same deletion mutation (600584.0012) in the NKX2E gene. The proband was diagnosed with ASD secundum and first-degree AV block that progressed to second-degree block; in 2 of her sibs, AV block also progressed to second degree, although 1 of those sibs had no cardiac malformation. ... One apparent asymptomatic carrier was found to have first-degree AV block on Holter monitoring. The conduction defect in this family was at the AV node, manifesting as first-degree block and evolving toward second-degree block; 3 patients also had atrial fibrillation, and 1 had unexplained ventricular tachycardia seen on Holter monitoring.
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Junctional Ectopic Tachycardia
Wikipedia
(See electrical conduction system of the heart ). The AV node acts as a gatekeeper, limiting the electrical activity that reaches the ventricles of the heart. This function of the AV node is important, because if the signals generated in the atria of the heart were to increase in rate (as they do during atrial fibrillation or atrial flutter ), the AV node will limit the electrical activity that conducts to the ventricles. For instance, if the atria are electrically activated at 300 beats per minute, half those electrical impulses are blocked by the AV node, so that the ventricles are activated at 150 beats per minute (giving a pulse of 150 beats per minute). Another important property of the AV node is that it slows down individual electrical impulses. ... Tachycardia (from the Greek takhys , meaning "swift", and kardia , meaning heart) means a swift heart rate. [11] By this definition, junctional ectopic tachycardia is an abnormally swift heart rhythm due to cells firing within the heart near the AV node. References [ edit ] ^ Sarubbi B, Vergara P, D'Alto M, Calabro R (2003).
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Aortic Valve Stenosis
GARD
Aortic valve stenosis (AVS) is a condition characterized by narrowing of the heart's aortic valve opening. This narrowing prevents the valve from opening fully, which obstructs blood flow from the heart into the aorta, and onward to the rest of the body. AVS can range from mild to severe. Signs and symptoms typically develop when the narrowing of the opening is severe and may include chest pain (angina) or tightness; shortness of breath or fatigue (especially during exertion); feeling faint or fainting; heart palpitations; and heart murmur. Individuals with less severe congenital AVS (present at birth) may not develop symptoms until adulthood. ... The condition can eventually lead to heart failure. AVS can have several causes including abnormal development before birth (such as having 1 or 2 valve leaflets instead of 3); calcium build-up on the valve in adulthood; and rheumatic fever .TNF, NPPC, VWF, ENO3, NOTCH1, GATA4, EBP, GATA5, FLI1, CCDC22, ROBO4, GLB1, BCOR, GATA6, FOXF1, NPHP3, FGFR1, FBN1, ARHGAP31, IFIH1, CRELD1, IDUA, TAB2, HAAO, WASHC5, NR2F2, WT1, CTSA, CHST3, ADAMTSL2, NOTCH2, SMAD6, CYP24A1, SMAD4, LTBP2, LPA, LMNA, B4GALT7, KRAS, SNIP1, ACTB, CBL, SLC2A10, ADAMTS10, NEK8, CLIC2, GNPTG, NKX2-5, EHMT1, ESCO2, AMER1, REN, NLRP6, CRP, LGALS3, ACE, APOE, AGT, NPPB, TGFB1, TNFRSF11B, APOB, PALMD, SPP1, MMP2, MAS1, FN1, OGN, NR1I2, IL10, CAD, APOA1, MMRN1, PON1, MLC1, SIRT1, MME, CD86, STS, IGF1, ACE2, RETN, MUC16, FCGR3A, FCGR3B, AHSG, SDC4, MIR424, TNNI3, TNNT2, TTN, AKAP12, GDF15, CILP, OGT, TTR, APLN, VDR, PDA1, PDE5A, CNBP, PTDSS1, TNFSF11, SCG2, LINC00273, ADIPOQ, MIR10B, MIR423, CRTAC1, SYPL2, KLF15, TLR2, KLF3, PCSK9, CRYGEP, RNLS, IL17RA, CHDH, MFN1, METTL3, MYL7, TRPV4, FTO, C1QTNF9, CRTC1, HDAC6, MIR19B1, ATP6AP2, PDPN, MIR34A, OGA, PPARGC1A, MIR210, MIR146A, STING1, MIR126, UTS2, ADAMTS13, WIF1, TEX41, DKK1, TBX22, PIK3CB, THOP1, CRYGC, CTH, CTSS, CYP11B2, DMD, ECE1, LPAR1, EDN1, EDNRA, ELN, ENG, ERBB4, ESR1, FH, FLNC, FOS, FOSB, GAPDH, MSTN, GH1, CCN2, CPOX, GUCY2D, CPB2, AGTR2, AKT1, ALOX5, ARSD, BCL2, CFB, BGN, BMP7, BSG, VPS51, DDR1, RUNX2, CBS, CD14, ENTPD1, CHGB, CLTA, CMA1, CNP, GLS, HSPA4, THBS2, NINJ1, SERPINE1, PIK3CA, JAG1, PIK3CD, PIK3CG, PITX1, PLTP, PPARG, PPP3CB, PSAP, PTPN1, PTPRC, S100A9, S100B, CCL2, SDC1, SLC2A1, SLC22A4, SOD3, NT5E, MYH7, HSPD1, MPO, TNC, IL6, IL6R, ITGAM, ITGB3, JARID2, JUN, JUNB, JUND, KDR, LDLR, LEP, LGALS4, LOX, MMP3, MMP9, MMP13, MMP14, MPG, CBSL
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Bradycardia
Wikipedia
This usually appears on an electrocardiogram (EKG) with a normal QRS complex accompanied with an inverted P wave either before, during, or after the QRS complex. [5] An AV-junctional escape beat is a delayed heartbeat originating from an ectopic focus somewhere in the AV junction . It occurs when the rate of depolarization of the SA node falls below the rate of the AV node . [5] This dysrhythmia also may occur when the electrical impulses from the SA node fail to reach the AV node because of SA or AV block . [7] This is a protective mechanism for the heart, to compensate for an SA node that is no longer handling the pacemaking activity, and is one of a series of backup sites that can take over pacemaker function when the SA node fails to do so. ... Those above the bundle of His, also known as junctional, will typically range between 40 and 60 BPM with a narrow QRS complex. [8] [9] In a third-degree heart block , about 61% take place at the bundle branch-Purkinje system, 21% at the AV node, and 15% at the bundle of His. [9] AV block may be ruled out with an EKG indicating "a 1:1 relationship between P waves and QRS complexes." [8] Ventricular bradycardias occurs with sinus bradycardia, sinus arrest, and AV block. ... Second-degree sinoatrial blocks can be detected only by use of a 12-lead EKG. [11] It is difficult and sometimes impossible to assign a mechanism to any particular bradycardia, but the underlying mechanism is not clinically relevant to treatment, which is the same in both cases of sick sinus syndrome: a permanent pacemaker . AV conduction disturbances (AV block; primary AV block , secondary type I AV block , secondary type II AV block , tertiary AV block ) may result from impaired conduction in the AV node, or anywhere below it, such as in the bundle of His. ... Clinical Sports Medicine. p. 259. ^ "AV Junctional Rhythm Disturbances (for Professionals)" .TAC1, CACNA1D, ADORA1, PDYN, HTR1A, KNG1, LHB, AGT, NTS, NISCH, POMC, GCG, PRL, UTS2, TACR1, TRH, GNRH1, GNAI2, EDN2, EDN1, DRD2, CYP2D6, EDN3, CYP1A1, CRH, CHRM2, MC4R, TRPM4, BRAT1, SGO1, TMEM43, GNB5, COQ9, QRICH1, LIPT1, MAGEL2, USP18, BSCL2, PPA2, HTRA2, PAX8, PRKAG2, AGPAT2, NPPA, GLUL, TSPYL1, DST, CACNA1C, CACNA2D1, SLC25A20, CASQ2, CAV1, FOS, CAVIN1, KCNH2, KCNJ2, KCNQ1, LMNA, PPARG, SCN9A, HCN4, SCN5A, ANK2
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Partial Atrioventricular Septal Defect
Orphanet
Shunting is restricted to the atrial level because of fusion of the leaflets of the common AV valve with the crest of the ventricular septum. ... An elevated pulmonary arterial pressure and moderate to severe left atrioventricular valve regurgitation may be observed. First-degree AV block, right bundle branch block, and a superior QRS axis may be noted on electrocardiogram. ... A pacemaker insertion may be required for complete AV block, which may spontaneously develop after repair. ... High morbidity and need for reoperation, often related to residual problems of the systemic AV valve or LAVV regurgitation, may be observed. ... Norwood-type intervention in infancy can be required, as well as prosthetic replacement of the left AV valve.