Part C, Embryo today : reviews vol. 105,2 (2015): 140–56. doi:10.1002/bdrc.21096 ^ a b c Bren L (28 February 2001). "Frances Oldham Kelsey: FDA Medical Reviewer Leaves Her Mark on History" . ... Retrieved 8 May 2015 . ^ a b Swan, Norman (28 June 2018). "Dr William McBride: The Flawed Character Credited with Linking Thalidomide to Birth Defects." ... Embryology.med.unsw.edu.au. Archived from the original on 28 October 2012 . Retrieved 30 December 2012 . ^ Millikin, Robert (20 February 1993). ... Archived from the original on July 28, 2012 . Retrieved June 6, 2013 . Alt URL ^ a b Zichner L, Rauschmann MA, Thomann KD (2005). ... PMID 12909394 . ^ "The plight of the thalidomide 'sample babies' who don't qualify for gov't compensation" . W5 . Retrieved 28 November 2016 . ^ Warren R (2001).

Minkoff et al. (1980) described a case of congenital intrinsic deficiency of the platelet membrane phospholipid, platelet factor-3, which plays an important role in acceleration of coagulation. The proband, a 28-year-old woman, had had lifelong excessive bleeding, without a family history of same.

All had renal agenesis, which was unilateral in 3 and bilateral in 1. One of the children, born at 28 weeks' gestation, died during the first hour of life. ... Mapping Alazami et al. (2009) performed genomewide multipoint parametric linkage analysis in 3 consanguineous families with BNAR, 1 of which had been previously reported by Al-Gazali et al. (2002), and obtained a maximum lod score of 6.62 between SNP markers rs10124106 and rs10963391, a 4.4-Mb interval on chromosome 9p23-p22.2 encompassing 28 annotated genes. Molecular Genetics In affected members of 3 consanguineous families with bifid nose with or without anorectal and renal anomalies mapping to chromosome 9p23-p22.2, including the Egyptian Arab family originally reported by Al-Gazali et al. (2002), Alazami et al. (2009) sequenced the candidate gene FREM1 (608944) and identified homozygosity for a 1-bp deletion and 2 missense mutations, respectively (608944.0001-608944.0003).

Clinical Features Zaremba et al. (1979) reported 4 affected persons in 3 generations, including a father and his 2 sons. One patient died at age 28 of multiple dilated thin-walled vessels in the cerebral substance; an extensive, irregularly shaped, pink hemangioma planum, which faded on pressure, was present on the skin of the left shoulder, arm and forearm. ... A daughter of the oldest of his sons (who died at age 28) had 3 angiomas in the lumbosacral area and 1 on the left palm.

. ^ a b c d e "Orphanet: Alpha thalassemia intellectual disability syndrome linked to chromosome 16 ATR 16 syndrome" . www.orpha.net . Retrieved 2015-10-28 . ^ a b "OMIM Entry – # 141750 – ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, CHROMOSOME 16-RELATED" . omim.org . Retrieved 2015-10-28 . External links [ edit ] Classification D ICD - 10 : D56.0 OMIM : 141750 MeSH : C563050 External resources Orphanet : 98791

However, the Swedish healthcare system received a lower score, questioning if it was sufficient and robust enough to treat the sick and protect health workers. [28] [note 3] In 2013, the Swedish Civil Contingencies Agency investigated Sweden's ability to cope with a pandemic through a simulation where a severe avian influenza infects a third of the population, out of which 190,000 gets severely ill, and up to 10,000 die from the disease. ... The latter had regarded disturbances in the drug supply as one of their biggest concerns in their annual risk assessments. [37] [36] [35] Timeline [ edit ] Main article: Timeline of the COVID-19 pandemic in Sweden COVID-19 cases in Sweden ( v t e ) Deaths Active cases 2020 2020 2021 2021 Feb Feb Mar Mar Apr Apr May May Jun Jun Jul Jul Aug Aug Sep Sep Oct Oct Nov Nov Dec Dec Jan Jan Last 15 days Last 15 days Date # of cases # of deaths 2020-02-04 1 (n.a.) 2020-02-05 1 (=) 2020-02-06 1 (=) 2020-02-07 1 (=) 2020-02-08 1 (=) 2020-02-09 1 (=) 2020-02-10 1 (=) 2020-02-11 1 (=) 2020-02-12 1 (=) 2020-02-13 1 (=) 2020-02-14 1 (=) 2020-02-15 1 (=) 2020-02-16 1 (=) 2020-02-17 1 (=) 2020-02-18 1 (=) 2020-02-19 1 (=) 2020-02-20 1 (=) 2020-02-21 1 (=) 2020-02-22 1 (=) 2020-02-23 1 (=) 2020-02-24 1 (=) 2020-02-25 1 (=) 2020-02-26 2 (+100%) 2020-02-27 3 (+50%) 2020-02-28 ​ 11 (+267%) 2020-02-29 ​ 14 (+27%) 2020-03-01 ​ 14 (=) 2020-03-02 ​ 19 (+36%) 2020-03-03 ​ 32 (+68%) 2020-03-04 ​ 62 (+94%) 2020-03-05 ​ 87 (+40%) 2020-03-06 ​ 146 (+68%) 2020-03-07 ​ 179 (+23%) 2020-03-08 ​ 225 (+26%) 2020-03-09 ​ 326 (+45%) 2020-03-10 ​ 424 (+30%) 2020-03-11 ​ 620 (+46%) 2 (n.a.) 2020-03-12 ​ 771 (+24%) 2 (=) 2020-03-13 ​ 923 (+20%) 3 (+50%) 2020-03-14 ​ 994 (+7.7%) 4 (+33%) 2020-03-15 ​ 1,063 (+6.9%) 6 (+50%) 2020-03-16 ​ 1,146 (+7.8%) 8 (+33%) 2020-03-17 ​ 1,265 (+10%) 9 (+12%) 2020-03-18 ​ ​ 1,410 (+11%) 15 (+67%) 2020-03-19 ​ ​ 1,553 (+10%) 22 (+47%) 2020-03-20 ​ ​ 1,733 (+12%) 31 (+41%) 2020-03-21 ​ ​ 1,869 (+7.8%) 39 (+26%) 2020-03-22 ​ ​ 1,987 (+6.3%) 50 (+28%) 2020-03-23 ​ ​ 2,169 (+9.2%) 61 (+22%) 2020-03-24 ​ ​ 2,399 (+11%) 82 (+34%) 2020-03-25 ​ ​ 2,713 (+13%) 104 (+27%) 2020-03-26 ​ ​ 2,999 (+11%) 135 (+30%) 2020-03-27 ​ ​ 3,364 (+12%) 167 (+24%) 2020-03-28 ​ ​ 3,664 (+8.9%) 202 (+21%) 2020-03-29 ​ ​ 3,944 (+7.6%) 240 (+19%) 2020-03-30 ​ ​ 4,360 (+11%) 285 (+19%) 2020-03-31 ​ ​ 4,835 (+11%) 333 (+17%) 2020-04-01 ​ ​ 5,321 (+10%) 386 (+16%) 2020-04-02 ​ ​ 5,875 (+10%) 456 (+18%) 2020-04-03 ​ ​ 6,476 (+10%) 536 (+18%) 2020-04-04 ​ ​ 6,833 (+5.5%) 606 (+13%) 2020-04-05 ​ ​ 7,173 (+5%) 691 (+14%) 2020-04-06 ​ ​ 7,562 (+5.4%) 781 (+13%) 2020-04-07 ​ ​ 8,300 (+9.8%) 865 (+11%) 2020-04-08 ​ ​ 8,954 (+7.9%) 980 (+13%) 2020-04-09 ​ ​ 9,599 (+7.2%) 1,066 (+8.8%) 2020-04-10 ​ ​ 10,053 (+4.7%) 1,156 (+8.4%) 2020-04-11 ​ ​ 10,448 (+3.9%) 1,258 (+8.8%) 2020-04-12 ​ ​ 10,912 (+4.4%) 1,355 (+7.7%) 2020-04-13 ​ ​ 11,349 (+4%) 1,439 (+6.2%) 2020-04-14 ​ ​ 11,828 (+4.2%) 1,531 (+6.4%) 2020-04-15 ​ ​ 12,432 (+5.1%) 1,646 (+7.5%) 2020-04-16 ​ ​ 13,055 (+5%) 1,757 (+6.7%) 2020-04-17 ​ ​ 13,743 (+5.3%) 1,840 (+4.7%) 2020-04-18 ​ ​ 14,275 (+3.9%) 1,926 (+4.7%) 2020-04-19 ​ ​ 14,663 (+2.7%) 2,013 (+4.5%) 2020-04-20 ​ ​ 15,124 (+3.1%) 2,098 (+4.2%) 2020-04-21 ​ ​ 15,831 (+4.7%) 2,160 (+3%) 2020-04-22 ​ ​ 16,553 (+4.6%) 2,237 (+3.6%) 2020-04-23 ​ ​ 17,311 (+4.6%) 2,323 (+3.8%) 2020-04-24 ​ ​ 18,091 (+4.5%) 2,412 (+3.8%) 2020-04-25 ​ ​ 18,564 (+2.6%) 2,485 (+3%) 2020-04-26 ​ ​ 18,864 (+1.6%) 2,559 (+3%) 2020-04-27 ​ ​ 19,427 (+3%) 2,633 (+2.9%) 2020-04-28 ​ ​ 20,169 (+3.8%) 2,716 (+3.2%) 2020-04-29 ​ ​ 20,968 (+4%) 2,799 (+3.1%) 2020-04-30 ​ ​ 21,604 (+3%) 2,877 (+2.8%) 2020-05-01 ​ ​ 22,136 (+2.5%) 2,955 (+2.7%) 2020-05-02 ​ ​ 22,435 (+1.4%) 3,028 (+2.5%) 2020-05-03 ​ ​ 22,696 (+1.2%) 3,103 (+2.5%) 2020-05-04 ​ ​ 23,173 (+2.1%) 3,187 (+2.7%) 2020-05-05 ​ ​ 23,830 (+2.8%) 3,259 (+2.3%) 2020-05-06 ​ ​ 24,575 (+3.1%) 3,332 (+2.2%) 2020-05-07 ​ ​ 25,359 (+3.2%) 3,412 (+2.4%) 2020-05-08 ​ ​ 26,060 (+2.8%) 3,472 (+1.8%) 2020-05-09 ​ ​ 26,569 (+2%) 3,540 (+2%) 2020-05-10 ​ ​ 26,848 (+1.1%) 3,613 (+2.1%) 2020-05-11 ​ ​ 27,303 (+1.7%) 3,678 (+1.8%) 2020-05-12 ​ ​ 28,057 (+2.8%) 3,739 (+1.7%) 2020-05-13 ​ ​ 28,755 (+2.5%) 3,789 (+1.3%) 2020-05-14 ​ ​ 29,412 (+2.3%) 3,835 (+1.2%) 2020-05-15 ​ ​ 30,100 (+2.3%) 3,893 (+1.5%) 2020-05-16 ​ ​ 30,458 (+1.2%) 3,941 (+1.2%) 2020-05-17 ​ ​ 30,717 (+0.85%) 3,994 (+1.3%) 2020-05-18 ​ ​ 31,147 (+1.4%) 4,053 (+1.5%) 2020-05-19 ​ ​ 31,813 (+2.1%) 4,094 (+1%) 2020-05-20 ​ ​ 32,621 (+2.5%) 4,146 (+1.3%) 2020-05-21 ​ ​ 33,231 (+1.9%) 4,199 (+1.3%) 2020-05-22 ​ ​ 33,763 (+1.6%) 4,255 (+1.3%) 2020-05-23 ​ ​ 34,166 (+1.2%) 4,310 (+1.3%) 2020-05-24 ​ ​ 34,376 (+0.61%) 4,354 (+1%) 2020-05-25 ​ ​ 34,867 (+1.4%) 4,396 (+0.96%) 2020-05-26 ​ ​ 35,613 (+2.1%) 4,424 (+0.64%) 2020-05-27 ​ ​ 36,413 (+2.2%) 4,462 (+0.86%) 2020-05-28 ​ ​ 37,187 (+2.1%) 4,502 (+0.9%) 2020-05-29 ​ ​ 37,960 (+2.1%) 4,543 (+0.91%) 2020-05-30 ​ ​ 38,392 (+1.1%) 4,582 (+0.86%) 2020-05-31 ​ ​ 38,657 (+0.69%) 4,628 (+1%) 2020-06-01 ​ ​ 39,305 (+1.7%) 4,667 (+0.84%) 2020-06-02 ​ ​ 40,205 (+2.3%) 4,703 (+0.77%) 2020-06-03 ​ ​ 41,251 (+2.6%) 4,731 (+0.6%) 2020-06-04 ​ ​ 42,290 (+2.5%) 4,774 (+0.91%) 2020-06-05 ​ ​ 43,436 (+2.7%) 4,811 (+0.78%) 2020-06-06 ​ ​ 44,216 (+1.8%) 4,840 (+0.6%) 2020-06-07 ​ ​ 44,678 (+1%) 4,873 (+0.68%) 2020-06-08 ​ ​ 45,355 (+1.5%) 4,911 (+0.78%) 2020-06-09 ​ ​ 46,292 (+2.1%) 4,944 (+0.67%) 2020-06-10 ​ ​ 47,729 (+3.1%) 4,984 (+0.81%) 2020-06-11 ​ ​ 49,022 (+2.7%) 5,019 (+0.7%) 2020-06-12 ​ ​ 50,351 (+2.7%) 5,048 (+0.58%) 2020-06-13 ​ ​ 51,383 (+2%) 5,081 (+0.65%) 2020-06-14 ​ ​ 51,801 (+0.81%) 5,108 (+0.53%) 2020-06-15 ​ ​ 52,486 (+1.3%) 5,138 (+0.59%) 2020-06-16 ​ ​ 53,695 (+2.3%) 5,166 (+0.54%) 2020-06-17 ​ ​ 55,152 (+2.7%) 5,198 (+0.62%) 2020-06-18 ​ ​ 56,646 (+2.7%) 5,227 (+0.56%) 2020-06-19 ​ ​ 57,855 (+2.1%) 5,257 (+0.57%) 2020-06-20 ​ ​ 58,553 (+1.2%) 5,286 (+0.55%) 2020-06-21 ​ ​ 58,874 (+0.55%) 5,308 (+0.42%) 2020-06-22 ​ ​ 59,674 (+1.4%) 5,328 (+0.38%) 2020-06-23 ​ ​ 60,983 (+2.2%) 5,353 (+0.47%) 2020-06-24 ​ ​ 62,681 (+2.8%) 5,375 (+0.41%) 2020-06-25 ​ ​ 63,959 (+2%) 5,398 (+0.43%) 2020-06-26 ​ ​ 65,163 (+1.9%) 5,409 (+0.2%) 2020-06-27 ​ ​ 65,918 (+1.2%) 5,423 (+0.26%) 2020-06-28 ​ ​ 66,333 (+0.63%) 5,446 (+0.42%) 2020-06-29 ​ ​ 67,060 (+1.1%) 5,462 (+0.29%) 2020-06-30 ​ ​ 67,864 (+1.2%) 5,482 (+0.37%) 2020-07-01 ​ ​ 68,549 (+1%) 5,497 (+0.27%) 2020-07-02 ​ ​ 69,236 (+1%) 5,512 (+0.27%) 2020-07-03 ​ ​ 69,930 (+1%) 5,520 (+0.15%) 2020-07-04 ​ ​ 70,294 (+0.52%) 5,535 (+0.27%) 2020-07-05 ​ ​ 70,609 (+0.45%) 5,544 (+0.16%) 2020-07-06 ​ ​ 70,860 (+0.36%) 5,559 (+0.27%) 2020-07-07 ​ ​ 71,138 (+0.39%) 5,571 (+0.22%) 2020-07-08 ​ ​ 71,671 (+0.75%) 5,582 (+0.2%) 2020-07-09 ​ ​ 72,005 (+0.47%) 5,597 (+0.27%) 2020-07-10 ​ ​ 72,374 (+0.51%) 5,611 (+0.25%) 2020-07-11 ​ ​ 72,682 (+0.43%) 5,621 (+0.18%) 2020-07-12 ​ ​ 72,788 (+0.15%) 5,629 (+0.14%) 2020-07-13 ​ ​ 72,958 (+0.23%) 5,641 (+0.21%) 2020-07-14 ​ ​ 73,270 (+0.43%) 5,649 (+0.14%) 2020-07-15 ​ ​ 73,557 (+0.39%) 5,655 (+0.11%) 2020-07-16 ​ ​ 73,825 (+0.36%) 5,661 (+0.11%) 2020-07-17 ​ ​ 74,109 (+0.38%) 5,668 (+0.12%) 2020-07-18 ​ ​ 74,300 (+0.26%) 5,679 (+0.19%) 2020-07-19 ​ ​ 74,410 (+0.15%) 5,686 (+0.12%) 2020-07-20 ​ ​ 74,541 (+0.18%) 5,692 (+0.11%) 2020-07-21 ​ ​ 74,767 (+0.3%) 5,699 (+0.12%) 2020-07-22 ​ ​ 75,064 (+0.4%) 5,705 (+0.11%) 2020-07-23 ​ ​ 75,284 (+0.29%) 5,710 (+0.09%) 2020-07-24 ​ ​ 75,546 (+0.35%) 5,713 (+0.05%) 2020-07-25 ​ ​ 75,684 (+0.18%) 5,714 (+0.02%) 2020-07-26 ​ ​ 75,726 (+0.06%) 5,716 (+0.04%) 2020-07-27 ​ ​ 75,797 (+0.09%) 5,722 (+0.1%) 2020-07-28 ​ ​ 76,080 (+0.37%) 5,726 (+0.07%) 2020-07-29 ​ ​ 76,381 (+0.4%) 5,727 (+0.02%) 2020-07-30 ​ ​ 76,683 (+0.4%) 5,727 (=) 2020-07-31 ​ ​ 76,941 (+0.34%) 5,729 (+0.03%) 2020-08-01 ​ ​ 77,244 (+0.39%) 5,731 (+0.03%) 2020-08-02 ​ ​ 77,282 (+0.05%) 5,734 (+0.05%) 2020-08-03 ​ ​ 77,447 (+0.21%) 5,738 (+0.07%) 2020-08-04 ​ ​ 77,780 (+0.43%) 5,740 (+0.03%) 2020-08-05 ​ ​ 78,205 (+0.55%) 5,741 (+0.02%) 2020-08-06 ​ ​ 78,583 (+0.48%) 5,745 (+0.07%) 2020-08-07 ​ ​ 78,963 (+0.48%) 5,747 (+0.03%) 2020-08-08 ​ ​ 79,223 (+0.33%) 5,748 (+0.02%) 2020-08-09 ​ ​ 79,296 (+0.09%) 5,752 (+0.07%) 2020-08-10 ​ ​ 79,492 (+0.25%) 5,754 (+0.03%) 2020-08-11 ​ ​ 79,909 (+0.52%) 5,758 (+0.07%) 2020-08-12 ​ ​ 80,352 (+0.55%) 5,761 (+0.05%) 2020-08-13 ​ ​ 80,715 (+0.45%) 5,766 (+0.09%) 2020-08-14 ​ ​ 81,059 (+0.43%) 5,767 (+0.02%) 2020-08-15 ​ ​ 81,285 (+0.28%) 5,768 (+0.02%) 2020-08-16 ​ ​ 81,348 (+0.08%) 5,768 (=) 2020-08-17 ​ ​ 81,522 (+0.21%) 5,771 (+0.05%) 2020-08-18 ​ ​ 81,836 (+0.39%) 5,775 (+0.07%) 2020-08-19 ​ ​ 82,187 (+0.43%) 5,776 (+0.02%) 2020-08-20 ​ ​ 82,520 (+0.41%) 5,778 (+0.03%) 2020-08-21 ​ ​ 82,818 (+0.36%) 5,783 (+0.09%) 2020-08-22 ​ ​ 82,978 (+0.19%) 5,784 (+0.02%) 2020-08-23 ​ ​ 83,035 (+0.07%) 5,787 (+0.05%) 2020-08-24 ​ ​ 83,209 (+0.21%) 5,788 (+0.02%) 2020-08-25 ​ ​ 83,431 (+0.27%) 5,789 (+0.02%) 2020-08-26 ​ ​ 83,675 (+0.29%) 5,791 (+0.03%) 2020-08-27 ​ ​ 83,877 (+0.24%) 5,792 (+0.02%) 2020-08-28 ​ ​ 84,056 (+0.21%) 5,793 (+0.02%) 2020-08-29 ​ ​ 84,187 (+0.16%) 5,794 (+0.02%) 2020-08-30 ​ ​ 84,235 (+0.06%) 5,797 (+0.05%) 2020-08-31 ​ ​ 84,397 (+0.19%) 5,799 (+0.03%) 2020-09-01 ​ ​ 84,568 (+0.2%) 5,802 (+0.05%) 2020-09-02 ​ ​ 84,781 (+0.25%) 5,804 (+0.03%) 2020-09-03 ​ ​ 85,067 (+0.34%) 5,806 (+0.03%) 2020-09-04 ​ ​ 85,329 (+0.31%) 5,806 (=) 2020-09-05 ​ ​ 85,500 (+0.2%) 5,806 (=) 2020-09-06 ​ ​ 85,567 (+0.08%) 5,809 (+0.05%) 2020-09-07 ​ ​ 85,752 (+0.22%) 5,810 (+0.02%) 2020-09-08 ​ ​ 85,988 (+0.28%) 5,811 (+0.02%) 2020-09-09 ​ ​ 86,302 (+0.37%) 5,813 (+0.03%) 2020-09-10 ​ ​ 86,556 (+0.29%) 5,815 (+0.03%) 2020-09-11 ​ ​ 86,847 (+0.34%) 5,819 (+0.07%) 2020-09-12 ​ ​ 87,053 (+0.24%) 5,820 (+0.02%) 2020-09-13 ​ ​ 87,159 (+0.12%) 5,822 (+0.03%) 2020-09-14 ​ ​ 87,379 (+0.25%) 5,824 (+0.03%) 2020-09-15 ​ ​ 87,671 (+0.33%) 5,825 (+0.02%) 2020-09-16 ​ ​ 88,001 (+0.38%) 5,827 (+0.03%) 2020-09-17 ​ ​ 88,390 (+0.44%) 5,828 (+0.02%) 2020-09-18 ​ ​ 88,827 (+0.49%) 5,829 (+0.02%) 2020-09-19 ​ ​ 89,106 (+0.31%) 5,830 (+0.02%) 2020-09-20 ​ ​ 89,239 (+0.15%) 5,834 (+0.07%) 2020-09-21 ​ ​ 89,505 (+0.3%) 5,836 (+0.03%) 2020-09-22 ​ ​ 89,943 (+0.49%) 5,837 (+0.02%) 2020-09-23 ​ ​ 90,496 (+0.61%) 5,837 (=) 2020-09-24 ​ ​ 91,036 (+0.6%) 5,838 (+0.02%) 2020-09-25 ​ ​ 91,666 (+0.69%) 5,842 (+0.07%) 2020-09-26 ​ ​ 91,991 (+0.35%) 5,844 (+0.03%) 2020-09-27 ​ ​ 92,158 (+0.18%) 5,845 (+0.02%) 2020-09-28 ​ ​ 92,536 (+0.41%) 5,846 (+0.02%) 2020-09-29 ​ ​ 93,149 (+0.66%) 5,848 (+0.03%) 2020-09-30 ​ ​ 93,838 (+0.74%) 5,852 (+0.07%) 2020-10-01 ​ ​ 94,471 (+0.67%) 5,853 (+0.02%) 2020-10-02 ​ ​ 95,183 (+0.75%) 5,856 (+0.05%) 2020-10-03 ​ ​ 95,644 (+0.48%) 5,859 (+0.05%) 2020-10-04 ​ ​ 95,800 (+0.16%) 5,862 (+0.05%) 2020-10-05 ​ ​ 96,174 (+0.39%) 5,864 (+0.03%) 2020-10-06 ​ ​ 96,960 (+0.82%) 5,868 (+0.07%) 2020-10-07 ​ ​ 97,791 (+0.86%) 5,871 (+0.05%) 2020-10-08 ​ ​ 98,625 (+0.85%) 5,872 (+0.02%) 2020-10-09 ​ ​ 99,408 (+0.79%) 5,877 (+0.09%) 2020-10-10 ​ ​ 99,917 (+0.51%) 5,882 (+0.09%) 2020-10-11 ​ ​ 100,078 (+0.16%) 5,884 (+0.03%) 2020-10-12 ​ ​ 100,715 (+0.64%) 5,887 (+0.05%) 2020-10-13 ​ ​ 101,631 (+0.91%) 5,888 (+0.02%) 2020-10-14 ​ ​ 102,599 (+0.95%) 5,890 (+0.03%) 2020-10-15 ​ ​ 103,501 (+0.88%) 5,893 (+0.05%) 2020-10-16 ​ ​ 104,680 (+1.1%) 5,895 (+0.03%) 2020-10-17 ​ ​ 105,377 (+0.67%) 5,899 (+0.07%) 2020-10-18 ​ ​ 105,698 (+0.3%) 5,900 (+0.02%) 2020-10-19 ​ ​ 106,469 (+0.73%) 5,904 (+0.07%) 2020-10-20 ​ ​ 107,759 (+1.2%) 5,908 (+0.07%) 2020-10-21 ​ ​ 109,330 (+1.5%) 5,911 (+0.05%) 2020-10-22 ​ ​ 110,996 (+1.5%) 5,920 (+0.15%) 2020-10-23 ​ ​ 112,864 (+1.7%) 5,927 (+0.12%) 2020-10-24 ​ ​ 114,341 (+1.3%) 5,935 (+0.13%) 2020-10-25 ​ ​ 114,855 (+0.45%) 5,943 (+0.13%) 2020-10-26 ​ ​ 115,924 (+0.93%) 5,954 (+0.19%) 2020-10-27 ​ ​ 118,338 (+2.1%) 5,963 (+0.15%) 2020-10-28 ​ ​ 121,728 (+2.9%) 5,972 (+0.15%) 2020-10-29 ​ ​ 124,990 (+2.7%) 5,981 (+0.15%) 2020-10-30 ​ ​ 129,046 (+3.2%) 5,990 (+0.15%) 2020-10-31 ​ ​ 132,033 (+2.3%) 6,003 (+0.22%) 2020-11-01 ​ ​ 133,330 (+0.98%) 6,025 (+0.37%) 2020-11-02 ​ ​ 134,899 (+1.2%) 6,045 (+0.33%) 2020-11-03 ​ ​ 138,507 (+2.7%) 6,064 (+0.31%) 2020-11-04 ​ ​ 142,989 (+3.2%) 6,085 (+0.35%) 2020-11-05 ​ ​ 147,733 (+3.3%) 6,107 (+0.36%) 2020-11-06 ​ ​ 152,187 (+3%) 6,132 (+0.41%) 2020-11-07 ​ ​ 156,638 (+2.9%) 6,159 (+0.44%) 2020-11-08 ​ ​ 158,735 (+1.3%) 6,181 (+0.36%) 2020-11-09 ​ ​ 162,460 (+2.3%) 6,216 (+0.57%) 2020-11-10 ​ ​ 166,957 (+2.8%) 6,251 (+0.56%) 2020-11-11 ​ ​ 172,667 (+3.4%) 6,278 (+0.43%) 2020-11-12 ​ ​ 178,233 (+3.2%) 6,306 (+0.45%) 2020-11-13 ​ ​ 184,963 (+3.8%) 6,339 (+0.52%) 2020-11-14 ​ ​ 188,476 (+1.9%) 6,377 (+0.6%) 2020-11-15 ​ ​ 190,057 (+0.84%) 6,416 (+0.61%) 2020-11-16 ​ ​ 192,602 (+1.3%) 6,453 (+0.58%) 2020-11-17 ​ ​ 197,061 (+2.3%) 6,495 (+0.65%) 2020-11-18 ​ ​ 202,023 (+2.5%) 6,546 (+0.79%) 2020-11-19 ​ ​ 209,639 (+3.8%) 6,591 (+0.69%) 2020-11-20 ​ ​ 215,099 (+2.6%) 6,636 (+0.68%) 2020-11-21 ​ ​ 219,592 (+2.1%) 6,687 (+0.77%) 2020-11-22 ​ ​ 222,014 (+1.1%) 6,746 (+0.88%) 2020-11-23 ​ ​ 225,890 (+1.7%) 6,801 (+0.82%) 2020-11-24 ​ ​ 231,565 (+2.5%) 6,868 (+0.99%) 2020-11-25 ​ ​ 237,631 (+2.6%) 6,938 (+1%) 2020-11-26 ​ ​ 244,534 (+2.9%) 6,997 (+0.85%) 2020-11-27 ​ ​ 250,996 (+2.6%) 7,061 (+0.91%) 2020-11-28 ​ ​ 254,821 (+1.5%) 7,111 (+0.71%) 2020-11-29 ​ ​ 257,575 (+1.1%) 7,162 (+0.72%) 2020-11-30 ​ ​ 261,057 (+1.4%) 7,228 (+0.92%) 2020-12-01 ​ ​ 266,877 (+2.2%) 7,296 (+0.94%) 2020-12-02 ​ ​ 273,424 (+2.5%) 7,367 (+0.97%) 2020-12-03 ​ ​ 280,410 (+2.6%) 7,443 (+1%) 2020-12-04 ​ ​ 287,748 (+2.6%) 7,513 (+0.94%) 2020-12-05 ​ ​ 292,613 (+1.7%) 7,556 (+0.57%) 2020-12-06 ​ ​ 294,416 (+0.62%) 7,636 (+1.1%) 2020-12-07 ​ ​ 298,198 (+1.3%) 7,694 (+0.76%) 2020-12-08 ​ ​ 305,644 (+2.5%) 7,748 (+0.7%) 2020-12-09 ​ ​ 314,040 (+2.7%) 7,823 (+0.97%) 2020-12-10 ​ ​ 320,732 (+2.1%) 7,909 (+1.1%) 2020-12-11 ​ ​ 328,451 (+2.4%) 7,994 (+1.1%) 2020-12-12 ​ ​ 334,989 (+2%) 8,063 (+0.86%) 2020-12-13 ​ ​ 338,046 (+0.91%) 8,131 (+0.84%) 2020-12-14 ​ ​ 341,583 (+1%) 8,224 (+1.1%) 2020-12-15 ​ ​ 348,587 (+2.1%) 8,309 (+1%) 2020-12-16 ​ ​ 357,412 (+2.5%) 8,410 (+1.2%) 2020-12-17 ​ ​ 367,053 (+2.7%) 8,528 (+1.4%) 2020-12-18 ​ ​ 374,971 (+2.2%) 8,599 (+0.83%) 2020-12-19 ​ ​ 380,481 (+1.5%) 8,679 (+0.93%) 2020-12-20 ​ ​ 384,233 (+0.99%) 8,770 (+1%) 2020-12-21 ​ ​ 389,395 (+1.3%) 8,842 (+0.82%) 2020-12-22 ​ ​ 395,992 (+1.7%) 8,928 (+0.97%) 2020-12-23 ​ ​ 407,370 (+2.9%) 9,011 (+0.93%) 2020-12-24 ​ ​ 412,406 (+1.2%) 9,096 (+0.94%) 2020-12-25 ​ ​ 415,200 (+0.68%) 9,198 (+1.1%) 2020-12-26 ​ ​ 418,167 (+0.71%) 9,290 (+1%) 2020-12-27 ​ ​ 421,377 (+0.77%) 9,384 (+1%) 2020-12-28 ​ ​ 428,472 (+1.7%) 9,500 (+1.2%) 2020-12-29 ​ ​ 437,348 (+2.1%) 9,570 (+0.74%) 2020-12-30 ​ ​ 447,806 (+2.4%) 9,645 (+0.78%) 2020-12-31 ​ ​ 454,807 (+1.6%) 9,738 (+0.96%) 2021-01-01 ​ ​ 457,425 (+0.58%) 9,804 (+0.68%) 2021-01-02 ​ ​ 459,958 (+0.55%) 9,884 (+0.82%) 2021-01-03 ​ ​ 462,714 (+0.6%) 9,953 (+0.7%) 2021-01-04 ​ ​ 469,695 (+1.5%) 10,008 (+0.55%) 2021-01-05 ​ ​ 477,239 (+1.6%) 10,046 (+0.38%) 2021-01-06 ​ ​ 482,271 (+1.1%) 10,078 (+0.32%) 2021-01-07 ​ ​ 489,423 (+1.5%) 10,122 (+0.44%) 2021-01-08 ​ ​ 495,124 (+1.2%) 10,160 (+0.38%) 2021-01-09 ​ ​ 499,861 (+0.96%) 10,194 (+0.33%) 2021-01-10 ​ ​ 502,179 (+0.46%) 10,232 (+0.37%) 2021-01-11 ​ ​ 506,830 (+0.93%) 10,254 (+0.22%) 2021-01-12 ​ ​ 512,172 (+1.1%) 10,277 (+0.22%) 2021-01-13 ​ ​ 518,779 (+1.3%) 10,286 (+0.09%) 2021-01-14 ​ ​ 523,486 (+0.91%) 10,289 (+0.03%) Source: Public Health Agency of Sweden – Folkhälsomyndigheten [a] [b] [c] Notes: ^ Data on cases and deaths is compiled by Folkhälsomyndigheten on weekdays (except Mondays) at 14:00 (CET).

See also: Abortion clinic Between 1982 and 1992, the number of abortion clinics in the state decreased by eight, going from 25 in 1982 to seventeen in 1992. [26] In 2014, the state had thirteen facilities that provided abortions, of which 8 were abortion clinics. [27] [28] In 2014, 88% of the counties in the state did not have an abortion clinic. ... Retrieved 2019-05-25 . ^ "Text-Only NPR.org : Nevada Law Removing Abortion Restrictions Passes State Assembly" . text.npr.org . Retrieved 2019-05-28 . ^ a b Kelly, Caroline. "Nevada passes bill to no longer require doctors to tell women the 'emotional implications' of an abortion" . CNN . Retrieved 2019-05-28 . ^ Veronica Stracqualursi and Chris Boyette. ... Guttmacher Institute . 2016-01-26 . Retrieved 2019-05-28 . ^ "Here's Where Women Have Less Access to Planned Parenthood" . ... Retrieved 2019-06-06 . ^ Low, Matt Donnelly,Gene Maddaus,Elaine; Donnelly, Matt; Maddaus, Gene; Low, Elaine (2019-05-28). "Netflix the Only Hollywood Studio to Speak Out in Attack Against Abortion Rights (Exclusive)" .

The genetic length of the interval between the 2 fragile sites was estimated to be 11 female centimorgans (95% probability interval: 4-28 cM). The estimate is comparable to those obtained by other methods.

Other features included movement disorder (44%), such as ataxia or spasticity, sleep disturbances (38%), seizures (25%), structural brain abnormalities (22%), growth delay (13%), macrocephaly (25%), digital anomalies (34%), somatic overgrowth (28%), and inverted nipples (13%). Dysmorphic facial features were common, although variable, and included tented upper lip, brachycephaly, midface hypoplasia, and low-set ears; there was no recognizable gestalt. In addition to the monozygotic twins (patients 27 and 28), there were 3 families in which a less severely affected parent carried the same heterozygous mutation as the proband (patients 1, 5, and 7). ... The patients were ascertained from a cohort of 313 individuals with intellectual disability who underwent trio-based whole-exome sequencing. In 28 patients from 27 unrelated families, including a set of monozygotic twins (patients 27 and 28), with DDVIBA, Vetrini et al. (2019) identified 25 heterozygous mutations in the TCF20 gene (see, e.g., 603107.0004-603107.0006).

Most of the patients are compound heterozygotes for PKHD1 mutations. [10] Patients with two nonsense mutations appear to have an earlier onset of the disease. [10] Diagnosis [ edit ] Autosomal recessive polycystic kidney disease with a normal kidney inset Ultrasonography is the primary method to evaluate autosomal recessive polycystic kidney disease, particularly in the perinatal and neonatal stages. [3] Differential diagnosis [ edit ] The differential diagnoses of this condition include: [5] Glomerulocystic kidney disease Autosomal dominant polycystic kidney disease Diffuse cystic dysplasia Treatment [ edit ] The treatment options for autosomal recessive polycystic kidney disease, given there is no current cure, are: [4] Medications for hypertension Medications and/or surgery for pain Antibiotics for infection Dialysis (if kidney failure is present) Kidney transplantation (in serious cases) References [ edit ] ^ a b "Autosomal recessive polycystic kidney disease - Symptoms - NHS Choices" . www.nhs.uk . Retrieved 2015-07-28 . ^ a b "Polycystic kidney disease" . Genetics Home Reference . Retrieved 2015-07-28 . ^ a b "Imaging in Autosomal Recessive Polycystic Kidney Disease: Overview, Radiography, Computed Tomography" . 2017-03-30. Cite journal requires |journal= ( help ) ^ a b "Polycystic Kidney Disease" . www.niddk.nih.gov . Retrieved 2015-07-28 . ^ a b Sweeney, William (1993). "Polycystic Kidney Disease, Autosomal Recessive" . Polycystic kidney Disease . NIH . Gene Review . Retrieved 28 July 2015 . ^ Bergmann C, Küpper F, Dornia C, Schneider F, Senderek J, Zerres K (March 2005).

Retrieved 11 May 2006 . old-form url ^ a b c d e [1] American Cancer Society . Retrieved 28 March 2013. ^ a b Gupta P, K Singhal, AK Jangra, V Nautiyal and A Pandey (2012) "Shark liver oil: A review" Archived 2013-01-23 at the Wayback Machine Asian Journal of Pharmaceutical Education and Research , 1 (2): 1-15. ^ a b Shark liver oil WebMD . Retrieved 28 March 2013. ^ PE-shark liver oil-cocoa buttr Rect WebMD . Retrieved 28 March 2013. ^ Hemorrhoidal suppository Daily Med . Retrieved 28 March 2013. ^ Oguri, M (1990) "A review of selected physiological characteristics unique to elasmobranchs" In: Elasmobranchs as living resources: advances in the biology, ecology, systematics and the status of the fisheries , eds.

Archived from the original (PDF) on 2007-09-29 . Retrieved 2007-01-28 . ^ Affolter, Verena K. (2004). "Histiocytic Proliferative Diseases in Dogs and Cats" . Proceedings of the 29th World Congress of the World Small Animal Veterinary Association . Retrieved 2007-01-28 . ^ Kearns, Shawn Ann; Ewing, Patty (Feb 2006). ... Compendium on Continuing Education for the Practicing Veterinarian . Veterinary Learning Systems. 28 (2): 122–133. ^ a b Cronin, Kim (Dec 2006).

There are several causes of blood loss including menstrual bleeding, gastrointestinal bleeding, stomach ulcers, and bleeding disorders. [28] The bleeding may occur quickly or slowly. ... Typically colon cancer occurs in older individuals [30] In addition, some bleeding disorders can cause gastrointestinal bleeding. [28] Two examples of bleeding disorders are von Willebrand disease and polycythemia vera . [28] Diet [ edit ] In many countries, wheat flour is fortified with iron. [31] The body normally gets the iron it requires from foods. ... NHLBI . 26 March 2014. Archived from the original on 28 July 2017 . Retrieved 17 July 2017 . ^ a b Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, et al. ... NHLBI . 26 March 2014. Archived from the original on 28 July 2017 . Retrieved 17 July 2017 . ^ "Iron" . ... "Iron deficiency and child development". Food and Nutrition Bulletin . 28 (4 Suppl): S560-71. doi : 10.1177/15648265070284S409 .

Signs and symptoms [ edit ] Signs and symptoms of DVT, while highly variable, include pain or tenderness, swelling, warmth, dilation of surface veins, redness or discoloration, and cyanosis with fever. [5] However, some with DVT have no symptoms. [18] Signs and symptoms alone are not sufficiently sensitive or specific to make a diagnosis, but when considered in conjunction with pre-test probability , can help determine the likelihood of DVT. [18] In most suspected cases, DVT is ruled out after evaluation, [21] and symptoms are more often due to other causes, such as ruptured Baker's cyst , cellulitis , hematoma , lymphedema , and chronic venous insufficiency . [1] Other differential diagnoses include tumors, venous or arterial aneurysms , and connective tissue disorders . [22] Causes [ edit ] Depiction of a deep vein thrombosis The three factors of Virchow's triad — venous stasis , hypercoagulability , and changes in the endothelial blood vessel lining—contribute to VTE and are used to explain its formation. [23] Venous stasis is the most consequential of these three factors. [9] Other related causes include activation of immune system components, the state of microparticles in the blood, the concentration of oxygen, and possible platelet activation. [24] Various risk factors contribute to VTE, including genetic and environmental factors, though many with multiple risk factors never develop it. [25] [12] Acquired risk factors include the strong risk factor of older age, [5] which alters blood composition to favor clotting. [26] Previous VTE, particularly unprovoked VTE, is a strong risk factor. [27] Major surgery and trauma increase risk because of tissue factor from outside the vascular system entering the blood. [28] Minor injuries, [29] lower limb amputation, [30] hip fracture , and long bone fractures are also risks. [8] In orthopedic surgery , venous stasis can be temporarily provoked by a cessation of blood flow as part of the procedure. [24] Inactivity and immobilization contribute to venous stasis, as with orthopedic casts , [31] paralysis, sitting, long-haul travel, bed rest, hospitalization, [28] and in survivors of acute stroke . [32] Conditions that involve compromised blood flow in the veins are May–Thurner syndrome , where a vein of the pelvis is compressed, and venous thoracic outlet syndrome , which includes Paget–Schroetter syndrome , where compression occurs near the base of the neck. [33] [34] [35] Cancer can grow in and around veins, causing venous stasis, and can also stimulate increased levels of tissue factor. [36] Cancers of the bone, ovary, brain, pancreas, and lymphomas are especially associated with increased VTE risk. [30] Chemotherapy treatment also increases risk. [37] Obesity increases the potential of blood to clot, as does pregnancy. ... Deficiencies in antithrombin , protein C , and protein S [c] are rare but strong, or moderately strong, risk factors. [28] [24] These three deficiencies increase the risk of VTE by about 10 times. [40] Factor V Leiden , which makes factor V resistant to inactivation by activated protein C , [39] mildly increases VTE risk by about three times. [10] [39] Having a non-O blood type roughly doubles VTE risk. [24] Non-O blood type is common globally, making it an important risk factor. [41] Individuals without O blood type have higher blood levels of von Willebrand factor and factor VIII than those with O blood type, increasing the likelihood of clotting. [41] Those homozygous for the common fibrinogen gamma gene variant rs2066865 have about a 1.6 times higher risk of VTE. [42] The genetic variant prothrombin G20210A , which increases prothrombin levels, [28] increases risk by about 2.5 times. [10] Additionally, approximately 5% of people have been identified with a background genetic risk comparable to the factor V Leiden and prothrombin G20210A mutations. [10] Blood alterations including dysfibrinogenemia , [31] low free protein S, [12] activated protein C resistance , [12] homocystinuria , [43] hyperhomocysteinemia , [28] high fibrinogen levels, [28] high factor IX levels, [28] and high factor XI levels [28] are associated with increased risk. ... The cephalic and basilic veins, however, are superficial veins. [11] The causes of arterial thrombosis , such as with heart attacks , are more clearly understood than those of venous thrombosis. [83] With arterial thrombosis, blood vessel wall damage is required, as it initiates coagulation , [83] but clotting in the veins mostly occurs without any such damage. [28] The beginning of venous thrombosis is thought to be caused by tissue factor, which leads to conversion of prothrombin to thrombin, followed by fibrin deposition. [37] Red blood cells and fibrin are the main components of venous thrombi, [28] and the fibrin appears to attach to the blood vessel wall lining (endothelium), a surface that normally acts to prevent clotting. [83] Platelets and white blood cells are also components. ... The score is used in suspected first lower extremity DVT (without any PE symptoms) in primary care and outpatient settings, including the emergency department . [1] [5] The numerical result (possible score −2 to 9) is most commonly grouped into either "unlikely" or "likely" categories. [1] [5] A Wells score of two or more means DVT is considered "likely" (about a 28% chance), while those with a lower score are considered "unlikely" to have DVT (about a 6% chance). [21] In those unlikely to have DVT, a diagnosis is excluded by a negative D-dimer blood test. [1] In people with likely DVT, ultrasound is the standard imaging used to confirm or exclude a diagnosis. [5] Imaging is also needed for hospital inpatients with suspected DVT and those initially categorized as unlikely to have DVT but who have a positive D-dimer test. [1] While the Wells score is the predominant and most studied clinical prediction rule for DVT, [21] [86] it does have drawbacks.

Mapping Hutchings et al. (2005) performed genomewide linkage analysis in 28 families with keratoconus recruited in France, Spain, and Guadeloupe (West Indies), representing a mixed, outbred population (Caucasian, Arab, and Caribbean African).

References [ edit ] ^ "Orthokeratosis (Concept Id: C1843359) - MedGen - NCBI" . www.ncbi.nlm.nih.gov . Retrieved 2019-10-28 . This cutaneous condition article is a stub .

The dystonic symptoms had remained focal in all cases over 9 years of disease duration on the average. Age of onset ranged between 28 and 70 years, with a mean of 58 years in generation II, 37 years in generation III, and 43 years in total. ... INHERITANCE - Autosomal dominant HEAD & NECK Eyes - Blepharospasm Mouth - Oromandibular dystonia Neck - Torticollis MUSCLE, SOFT TISSUES - Hypertrophic muscles NEUROLOGIC Central Nervous System - Cranial dystonia - Torsion dystonia - Dysphonia - Clumsiness - Tremor - Postural hand tremor - Dystonic writer's cramp MISCELLANEOUS - Age of onset 28 to 70 years - Symptoms remain focal ▲ Close

A number sign (#) is used with this entry because this disorder is caused by copy number increase of a 5.1-Mb region of chromosome Xq27.3-q28 encompassing at least 28 genes, including FMR1 (309550). Description Chromosome Xq27.3-q28 duplication syndrome is an X-linked recessive neurodevelopmental disorder characterized by mild mental retardation, mild facial dysmorphism, short stature, and primary testicular failure manifest as high-pitched voice, sparse body hair, abdominal obesity, and small testes. ... Cytogenetics Using array CGH in a French family with X-linked syndromic mental retardation, Rio et al. (2010) identified a 5.1-Mb duplication of chromosome Xq27.3-q28 encompassing at least 28 genes. The region included the FMR1 (309550), FMR2 (AFF2; 300806), IDS (300823), and MTM1 (300415) genes, but not MECP2 (300005).

The New England Journal of Medicine . 369 (6): 517–28. doi : 10.1056/nejmoa1211115 . PMC 3889161 . ... The New England Journal of Medicine . 369 (6): 517–28. doi : 10.1056/nejmoa1211115 . PMC 3889161 .

Dysmorphic facial features included frontal bossing, a large anterior fontanel, slight hypertelorism, anteverted nares, flat nasal bridge, and slight micrognathia. At 28 months, he presented with dimples on the sides of his ankles, as well as fat pads on the dorsa of feet and toes and pronounced plantar creases on both sides. ... Tissue abundance of the mutated DICER DNA ranged from 21 to 37% in patient 1 and 28 to 47% in patient 2 in blood, tumor, and unaffected kidney samples.