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  • Vertebral Artery Dissection Wikipedia
    From 1994 to 2003, the incidence increased threefold; this has been attributed to the more widespread use of modern imaging modalities rather than a true increase. [1] Similarly, those living in urban areas are more likely to receive appropriate investigations, accounting for increased rates of diagnosis in those dwelling in cities. It is suspected that a proportion of cases in people with mild symptoms remains undiagnosed. [2] There is controversy as to whether VAD is more common in men or in women; an aggregate of all studies shows that it is slightly higher incidence in men (56% versus 44%). [1] Men are on average 37–44 years old at diagnosis, and women 34–44.
    COL3A1, COL5A2, C20orf181
  • Female Foeticide In India Wikipedia
    Ultrasound sex discernment technologies were first introduced in major cities of India in 1980s, its use expanded in India's urban regions in 1990s, and became widespread in 2000s. [17] Magnitude estimates for female foeticide [ edit ] Estimates for female foeticide vary by scholar.
  • Transmission And Infection Of H5n1 Wikipedia
    Poultry farming practices [ edit ] There have been a number of farming practices that have changed in response to outbreaks of the H5N1 virus, including: vaccinating poultry against bird flu vaccinating poultry workers against human flu limiting travel in areas where H5N1 is found increasing farm hygiene reducing contact between livestock and wild birds reducing open-air wet markets limiting workers contact with cock fighting reducing purchases of live fowl improving veterinary vaccine availability and cost. [19] For example, after nearly two years of using mainly culling to control the virus, the Vietnamese government in 2005 adopted a combination of mass poultry vaccination, disinfecting, culling, information campaigns and bans on live poultry in cities. [20] Dealing with outbreaks [ edit ] The majority of H5N1 flu cases have been reported in southeast and east Asia.
  • Mesoamerican Nephropathy Wikipedia
    In April 2013, a high-level meeting with regional health ministries, nongovernmental organizations, aid agencies, clinical specialists and researchers was held in San Salvador city, El Salvador , leading the Panamerican Health Organization (PAHO) to finally declare CKDu "a pressing and extremely serious health problem in the region".
  • Red Scare Wikipedia
    Attorney General Alexander Mitchell Palmer , and immigration officials. On June 2, 1919, in eight cities, eight bombs simultaneously exploded .
  • Carbon Monoxide Poisoning Wikipedia
    Causes [ edit ] Concentration Source 0.1 ppm Natural atmosphere level ( MOPITT ) [48] 0.5 to 5 ppm Average level in homes [49] 5 to 15 ppm Near properly adjusted gas stoves in homes [49] 100 to 200 ppm Exhaust from automobiles in the Mexico City central area [50] 5,000 ppm Exhaust from a home wood fire [51] 7,000 ppm Undiluted warm car exhaust without a catalytic converter [51] 30,000 ppm Afterdamp following an explosion in a coal mine [52] Carbon monoxide is a product of combustion of organic matter under conditions of restricted oxygen supply, which prevents complete oxidation to carbon dioxide (CO 2 ). ... "Carbon monoxide poisonings associated with snow-obstructed vehicle exhaust systems—Philadelphia and New York City, January 1996" . MMWR. Morbidity and Mortality Weekly Report . 45 (1): 1–3.
    HMOX1, MBP, NOS1, XDH
    • Carbon Monoxide Poisoning Mayo Clinic
      Overview Carbon monoxide poisoning occurs when carbon monoxide builds up in the blood. When too much carbon monoxide is in the air, the body replaces the oxygen in the red blood cells with carbon monoxide. This can lead to serious tissue damage, or even death. Carbon monoxide is gas that has no odor, taste or color. Burning fuels, including gas, wood, propane or charcoal, make carbon monoxide. Appliances and engines that aren't well vented can cause the gas to build up to dangerous levels.
  • Leprosy Wikipedia
    Located at Balathal, in Rajasthan, northwest India, the discoverers suggest that if the disease did migrate from Africa to India, during the third millennium BCE "at a time when there was substantial interaction among the Indus Civilization, Mesopotamia, and Egypt, there needs to be additional skeletal and molecular evidence of leprosy in India and Africa so as to confirm the African origin of the disease." [105] A proven human case was verified by DNA taken from the shrouded remains of a man discovered in a tomb next to the Old City of Jerusalem dated by radiocarbon methods to 1–50 AD. [106] Distribution of leprosy around the world in 1891 However, a study published in 2018 found the oldest strains of leprosy in remains from Europe, the oldest strain being from Great Chesterford in southeast England and dating back to 415 to 545 AD. ... Further details may exist on the talk page . ( August 2020 ) Medieval leper bell It is believed that a rise in leprosy in Western Europe occurred in the Middle Ages based on the increased number of hospitals created to treat people with leprosy in the 12th and 13th centuries. [128] [129] [130] France alone had nearly 2,000 leprosariums during this period. [131] The social perception of leprosy in medieval communities was generally one of fear, and people infected with the disease were thought to be unclean, untrustworthy, and morally corrupt. [127] Segregation from mainstream society was common, and people with leprosy were often required to wear clothing that identified them as such or carry a bell announcing their presence. [131] The third Lateran Council of 1179 and a 1346 edict by King Edward expelled lepers from city limits. Because of the moral stigma of the disease, methods of treatment were both physical and spiritual, and leprosariums were established under the purview of the Roman Catholic Church . [127] [132] 19th century [ edit ] A 24-year-old man with leprosy (1886) Norway [ edit ] Norway was the location of a progressive stance on leprosy tracking and treatment and played an influential role in European understanding of the disease.
    CCDC88B, SLC11A1, TLR2, TLR1, IL23R, RAB32, BATF3, LTA, HLA-DRB1, LACC1, CCDC122, TNFSF15, C1orf141, HLA-B, PRKN, TNF, RIPK2, SIGLEC5, IL18R1, IL10, IL1RL1, LINC02571, DELEC1, FILIP1, BBS9, COX4I1, CDH18, SLC2A13, RMI2, SNX20, LINC01091, WASF5P, UBE2V1P15, LINC00690, IFNG, NOD2, VDR, LRRK2, SDHD, PACRG, IL6, MBL2, RBM45, TLR4, MICA, ERBB2, IL4, IL12B, BTNL2, HLA-A, HSPD1, HLA-DQA1, IL2, GEM, S100A6, DDX39A, SLC26A3, MRC1, NGF, CFP, CCL4, CFH, DDX39B, TOLLIP, TGFBR2, KIR3DL1, CTLA4, IL17F, SLC7A9, IL2RA, HSD11B2, APOE, IL1B, IL10RB, CXCL10, IL17A, IL12RB2, BCHE, CD209, ACTG2, IL22, CCR2, TOR1B, FOXP3, NT5C3A, POTEM, CD274, IL37, CYP2E1, PARL, CYP19A1, ACAD8, RNU1-1, NUPR1, H3C9P, SPAG8, PTPN22, NLRP1, ACOT7, ACTG1, POTEKP, EMC3, CR1, ADGB, PWAR1, CASP8, APOA1, STING1, CD14, TNFSF8, CD40, IRGM, TIRAP, CD40LG, DEFB1, ACTBL2, IL26, GAL3ST4, SLC52A2, PINK1, CCR5, ANXA2, ZNF410, HAMP, MAVS, AKR1B10, ANXA1, FMNL1, HLA-DQB1, SOCS1, MASP2, MFN2, PCK1, HIF1A, PAEP, NOS2, NFKBIL1, MPZ, MNAT1, MICB, CIITA, LTB, LGALS3, LDLR, KIR3DL2, KIR2DS1, KDR, ISG20, IL15, IL13RA1, IL13, IL10RA, HLA-C, CXCR2, IL5RA, IL1RN, IL1A, IGF1, HSPE1, POLG, PREP, RNU1-4, FLNA, BMS1, FHL5, IL32, MAP3K14, BCL10, NR1I2, F2R, FCN1, FCN2, HLA-DRB4, FCN3, VEGFA, TOP2A, S100A1, CXCR3, GSTM1, TGFBR1, TGFB1, TFAM, TAP1, STAT3, SOD2, SLAMF1, ACACA, CCL3, S100B, SERPINA3
    • Leprosy, Susceptibility To, 1 OMIM
      LPRS1 is a locus for susceptibility to paucibacillary leprosy on chromosome 10p13. In addition to information on LPRS1 (see MAPPING), this entry includes a discussion of susceptibility to leprosy in general and information on genetic heterogeneity (see HETEROGENEITY). Description Leprosy is a disease of peripheral sensory nerves that results from infection with Mycobacterium leprae, which was first detected in Bergen, Norway, in 1873 by Dr. Armauer Hansen. It can be effectively treated with long-term multidrug therapy. In 2006, more than 250,000 new cases of leprosy were reported to the World Health Organization.
    • Leprosy, Susceptibility To, 5 OMIM
      A number sign (#) is used with this entry because this form of susceptibility to leprosy (LPRS5) is associated with a polymorphism in the TLR1 gene (601194). A polymorphism in the TLR1 gene is also associated with protection against leprosy. See 609888 for a discussion of leprosy susceptibility in general and information on genetic heterogeneity. Mapping LPRS5 is associated with a polymorphism in the TLR1 gene, which Taguchi et al. (1996) mapped to chromosome 4p14. Molecular Genetics Schuring et al. (2009) studied association of an asn248-to-ser (N248S; 601194.0002) SNP in the TLR1 gene and leprosy in a Bangladeshi population consisting of 842 patients and 543 controls.
    • Leprosy, Susceptibility To, 2 OMIM
      See 609888 for a discussion of leprosy susceptibility in general and information on genetic heterogeneity. Mapping In a study in a Vietnamese population, Mira et al. (2003) found significant evidence for a susceptibility gene for leprosy on chromosome region 6q25; maximum likelihood binomial (MLB) lod score was 4.31. They confirmed this by family-based association analysis in an independent panel of 208 Vietnamese leprosy simplex families (i.e., families with 2 unaffected parents and 1 affected child). Mira et al. (2003) confirmed the linkage of paucibacillary leprosy to 10p13 (LPRS1; 609888), as reported by Siddiqui et al. (2001). Their evidence suggested that the 6q25 locus is involved in leprosy of both the paucibacillary and multibacillary types.
    • Leprosy, Susceptibility To, 3 OMIM
      A number sign (#) is used with this entry because this form of susceptibility to leprosy (LPRS3) is associated with a polymorphism in the TLR2 gene (603028) on chromosome 4q32. See 609888 for a discussion of leprosy susceptibility in general and information on genetic heterogeneity. Mapping LPRS3 is associated with a polymorphism in the TLR2 gene, which Rock et al. (1998) mapped to chromosome 4q32. Molecular Genetics Kang and Chae (2001) identified an arg677-to-trp polymorphism (R677W; 603028.0001) in the intracellular domain of TLR2 in 10 (22%) of 45 Korean lepromatous leprosy patients, but not in any of 41 Korean tuberculoid patients or 45 Korean controls. They concluded that the R677W polymorphism in TLR2 has a role in susceptibility to lepromatous leprosy.
    • Leprosy, Susceptibility To, 6 OMIM
      See 609888 for a discussion of leprosy susceptibility in general and information on genetic heterogeneity. Mapping Zhang et al. (2009) performed a genomewide association study to identify leprosy susceptibility loci in 706 patients and 1,225 controls, all of whom were self-identified Han Chinese from eastern China. Diagnosis was made on the basis of the consensus of at least 2 dermatologists. Patients and controls reported an absence of M. tuberculosis and other chronic infections. Controls lacked a history of leprosy in themselves and their families, as well as autoimmune and systemic disorders.
    • Leprosy Orphanet
      A chronic infectious disease affecting primarily the skin and peripheral nervous system. Epidemiology Worldwide annual incidence is estimated at 250,000 cases, with a large majority in India and Brazil. Clinical description A wide clinical spectrum has been described from a polar tuberculoid (localized) form (TT) to a polar lepromatous (disseminated) one (LL). Borderline forms exist: borderline tuberculoid, borderline borderline and borderline lepromatous (BT, BB, BL). Tuberculoid leprosy (TLep) or paucibacillary form includes TT and BT and lepromatous leprosy (LLep) or multibacillary form includes LL, BL and BB.
    • Leprosy, Susceptibility To, 4 OMIM
      A number sign (#) is used with this entry because susceptibility to early-onset leprosy is associated with a polymorphism in the LTA gene (153440) on chromosome 6p21.3. This polymorphism accounts, in part, for susceptibility to leprosy linked to chromosome 6p21.3 (LPRS4). However, additional genetic risk factors likely underlie susceptibility to leprosy linked to chromosome 6p21.3. See 609888 for a discussion of leprosy susceptibility in general and information on genetic heterogeneity. Mapping Mira et al. (2003) detected a linkage peak associated with leprosy in the 6p21 chromosomal region, which fine mapping placed close to D6S2427 (lod = 2.7).
    • Hansen's Disease GARD
      Hansen's disease (also known as leprosy) is a rare bacterial infection that affects the skin, nerves and mucous membranes . After exposure, it may take anywhere from 2 to 10 years to develop features of the condition. Once present, common signs and symptoms include skin lesions ; muscle weakness or paralysis; eye problems that may lead to blindness; nosebleeds; severe pain; and/or numbness in the hands, feet, arms and legs. Hansen's disease is caused by the bacterium Mycobacterium leprae; however, the way in which the bacterium is transmitted (spread) is poorly understood. It appears that only about 5% of people are susceptible to the condition.
  • Criminal Transmission Of Hiv Wikipedia
    It has been demonstrated that these types of laws increase HIV stigma and negatively affect public health. [78] [79] HIV non-disclosure laws and criminalization of HIV transmission may make people less likely to access HIV testing [80] and less likely to disclosure their status [78] or discuss sexual health with a healthcare provider. [80] Although women only make up 10% of Canadian non-disclosure prosecutions, there is an overrepresentation of prosecuted sex workers , Indigenous women, and abuse survivors. [80] There is also a higher proportion of women and indigenous people involved in cases based on low levels of blameworthiness (i.e. difficult life circumstance, spontaneous sexual acts, compliance with authorities, condom use, and evidence that the accused was abused by the complainant). [81] South Africa's openly HIV-positive Supreme Court Justice Edwin Cameron argued against criminalisation at the XVII International AIDS Conference in Mexico City. See also [ edit ] STD notifications in dating services Electronic health record (EHR) Electronic medical record (EMR) Criminal transmission of HIV by various people Intentional contagion of infection References [ edit ] ^ "CDC : Centers for Disease Control and Prevention Homepage" . ... External links [ edit ] Criminal Transmission of HIV - list of notable cases HIV and the criminal law (International resource from NAM) Criminal HIV Transmission Research Project Tops 100 Online Profiles Information concerning a number of European countries Information concerning England and Wales More information concerning England and Wales Canadian HIV/AIDS Legal Network HIV & AIDS Legal Clinic (Ontario)Canada The Center for HIV Law & Policy - Positive Justice Project NAM Aids Map - Transmission of HIV as a criminal offence WHO technical consultation - A report by the World Health Organization on Criminalizing HIV Transmission Keele University Research Institute for Law, Politics and Justice - The legal, political and social problems associated with HIV were discussed at a seminar series at Keele University in 2005/6. v t e Sexual ethics Human sexuality Adolescent sexuality Rainbow party Adultery Education Fetishism Incest law Miscegenation Objectification Orientation Pregnancy Abortion Prostitution law Survival sex Child sexuality Child marriage Child pornography law Child prostitution Child sex tourism Sexual abuse Child-on-child sexual abuse Child sexual abuse law Cybersex trafficking Harassment Rape law Sex trafficking Sexual slavery Age of consent ( reform ) Africa Asia Europe North America United States Oceania South America Topical outline v t e HIV / AIDS topics HIV/AIDS HIV HIV Lentivirus structure and genome subtypes CDC classification disease progression rates HIV/AIDS diagnosis management pathophysiology prevention research vaccination PrEP WHO disease staging system for HIV infection and disease Children Teens / Adults Countries by AIDS prevalence rate Conditions Signs and symptoms AIDS-defining clinical condition Diffuse infiltrative lymphocytosis syndrome Lipodystrophy Nephropathy Neurocognitive disorders Pruritus Superinfection Tuberculosis co-infection HIV Drug Resistance Database Innate resistance to HIV Serostatus HIV-positive people Nutrition Pregnancy History History Epidemiology Multiple sex partners Timeline AIDS Museum Timothy Ray Brown Women and HIV/AIDS Social AIDS orphan Catholic Church and HIV/AIDS Circumcision and HIV Criminal transmission Discrimination against people Economic impact Cost of treatment HIV-affected community HIV/AIDS activism HIV/AIDS denialism Red ribbon Safe sex Sex education List of HIV-positive people People With AIDS Self-Empowerment Movement HIV/AIDS in the porn industry Culture Discredited HIV/AIDS origins theories International AIDS Conference International AIDS Society Joint United Nations Programme on HIV/AIDS (UNAIDS) Media portrayal of HIV/AIDS Misconceptions about HIV/AIDS President's Emergency Plan for AIDS Relief (PEPFAR) The SING Campaign Solidays Treatment Action Campaign World AIDS Day YAA/Youthforce "Free Me" Larry Kramer Gay Men's Health Crisis ACT UP Silence=Death Project HIV/AIDS pandemic by region / country Africa Angola Benin Botswana Democratic Republic of the Congo Egypt Eswatini Ethiopia Ghana Guinea Côte d'Ivoire (Ivory Coast) Kenya Lesotho Madagascar Malawi Mali Mozambique Namibia Niger Nigeria Rwanda Senegal Tanzania South Africa Uganda Zambia Zimbabwe North America Canada Mexico El Salvador Guatemala Honduras Nicaragua United States New York City Caribbean Haiti Jamaica Dominican Republic South America Bolivia Brazil Colombia Guyana Peru Asia Afghanistan Armenia Azerbaijan Bahrain Bangladesh Bhutan Cambodia China (PRC) ( Yunnan ) East Timor India Indonesia Iran Iraq Japan Jordan North Korea Laos Malaysia Myanmar (Burma) Nepal Pakistan Philippines Saudi Arabia Sri Lanka Taiwan (ROC) Thailand United Arab Emirates Turkey Vietnam Europe United Kingdom Russia Ukraine Oceania Australia New Zealand Papua New Guinea List of countries by HIV/AIDS adult prevalence rate List of HIV/AIDS cases and deaths registered by region
  • Helminthiasis Wikipedia
    Soil is eaten, for example, by children or pregnant women to counteract a real or perceived deficiency of minerals in their diet. [28] Diagnosis [ edit ] Identification and quantification of helminth eggs at UNAM university in Mexico City, Mexico Specific helminths can be identified through microscopic examination of their eggs (ova) found in faecal samples.
    IL4, IL13, IL5, IL10, IL33, IL9, IFNG, IL25, IL17A, FOXP3, MYDGF, CCL11, BCL11B, NELFCD, GREM1, PRDX5, NMUR1, ADIPOQ, IL1RL1, ABO, FBXW7, EOMES, SUCNR1, RETN, CYSLTR2, CLEC7A, NBEAL1, FUZ, SETD7, NLRP3, LINGO2, SERPINA13P, SUCLA2, STAT6, TYROBP, FCER2, AGXT, ARNTL, TNFRSF8, TNFSF8, CD38, CRP, CSF2, CTSB, EGFR, MS4A2, GAMT, TNFRSF4, GLB1, IL1A, IL1B, IL4R, ITGAX, LTBR, SERPINA1, ADCY9, TGFB1, TNFSF4, MIR155
  • Trichotillomania Wikipedia
    . ^ "Hannah Sussman's Art Imitates Life Join Her For a Screening October 3rd" . Century City News. September 28, 2009. Archived from the original on December 16, 2009 .
    SLITRK1, HOXB8, PTCH1, PHIP, TRAF7, SHANK3, KDR, NOS2, TLR9
    • Trichotillomania OMIM
      A number sign (#) is used with this entry because of evidence that trichotillomania is caused by heterozygous mutation in the SLITRK1 gene (609678) on chromosome 13q31. One such patient has been reported. Description Trichotillomania (TTM) is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. The activity causes distress to the individual and often interferes with functioning. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Tourette syndrome (GTS; 137580) or obsessive-compulsive disorder (OCD; 164230) (review by Novak et al., 2009). Clinical Features Kerbeshian and Burd (1991) reported a 37-year-old woman with trichotillomania manifest as chronic pulling out of her eyebrows and eyelashes.
  • Cysticercosis Wikipedia
    The distribution of cysticercosis coincides with the distribution of T. solium . [53] Cysticercosis is the most common cause of symptomatic epilepsy worldwide. [54] Prevalence rates in the United States have shown immigrants from Mexico, Central and South America, and Southeast Asia account for most of the domestic cases of cysticercosis. [55] In 1990 and 1991, four unrelated members of an Orthodox Jewish community in New York City developed recurrent seizures and brain lesions, which were found to have been caused by T. solium . ... "Neurocysticercosis in an Orthodox Jewish Community in New York City". New England Journal of Medicine . 327 (10): 692–695. doi : 10.1056/NEJM199209033271004 .
    TAC1, DUT, GAMT, OCA2, PDR, SLC12A3, SST, TLR4, PART1, GREM1, SLCO6A1, GSTK1
    • Cysticercosis Orphanet
      Cysticercosis is a parasitic infectious disease characterized by cyst formation in the target tissue of Taenia solium (tapeworm) parasite larvae ingested via the feces of a human with a tapeworm (human-to-human fecal-oral transmission) leading to variable clinical manifestations in muscle, the brain, spinal cord, and eyes. Infection of muscle tissue is generally asymptomatic. Cyst development in the brain and spinal cord is known as neurocysticercosis (NCC) and may cause seizures and headache. NCC can follow a serious course and may be life-threatening. Severe cases of cysticercosis are treated with albendazole and anti-inflammatory drugs.
    • Cysticercosis GARD
      Cysticercosis is an infection caused by the pork tapeworm, Taenia solium . The condition develops when tapeworm eggs, which can be found in contaminated food, enter the body and form cysticeri (cysts). In most cases, the worms stay in the muscles and do not cause symptoms. However, symptoms may be present when the infection is found in the brain, eyes, heart or spine. Although rare in the United States, cysticercosis is common in many developing countries.
  • Tularemia Wikipedia
    . - Retrieved 3 Jan 2012 ^ Smith S (2005-03-29). "City tells BU to bolster safety of its medical labs" .
  • Marfan Syndrome Wikipedia
    Today, cardiovascular symptoms of Marfan syndrome are still the most significant issues in diagnosis and management of the disease, but adequate prophylactic monitoring and prophylactic therapy offers something approaching a normal lifespan, and more manifestations of the disease are being discovered as more patients live longer. [56] Women with Marfan syndrome live longer than men. [10] Epidemiology [ edit ] Marfan syndrome affects males and females equally, [57] and the mutation shows no ethnic or geographical bias. [6] Estimates indicate about 1 in 5,000 to 10,000 individuals have Marfan syndrome. [3] History [ edit ] Marfan syndrome is named after Antoine Marfan , [7] the French pediatrician who first described the condition in 1896 after noticing striking features in a five-year-old girl. [8] [58] The gene linked to the disease was first identified by Francesco Ramirez at the Mount Sinai Medical Center in New York City in 1991. [59] See also [ edit ] Ehlers–Danlos syndrome Kashin–Beck disease Loeys–Dietz syndrome Mitral valve prolapse References [ edit ] ^ a b c d e f g h i j k l m n o p q "What Is Marfan Syndrome?"
    FBN1, TGFBR2, LTBP2, MMP2, CBS, NOS2, MMP9, SOD2, LAMC1, CAT, SOD1, TGFBR1, MUS81, FBN2, KCNQ1, EGF, ELN, TGFB1, AGTR1, COL1A2, AGT, TGFB2, DCN, SMAD2, COL3A1, COX2, PKD1, MMP14, PPARG, MAPK1, LRP1, TAGLN, TNF, ADAMTS1, SMAD3, MMRN1, ADAMTSL4, CD109, ACTA2, MAPK3, LOX, BGLAP, SLC35A1, FBLN5, RBM8A, GAL3ST1, BRAF, GRAP2, KLF4, SLC33A1, CLDN6, AXIN2, HBHR, AIMP2, VWF, TRPV1, VEGFA, TP53, VPS51, TIMP3, TIMP2, AHSA1, SIRT1, FADS3, PART1, CST12P, CBSL, PGR-AS1, SPESP1, PTPRVP, ALOX5, DCBLD2, FBN3, SPRTN, ANGPT2, P3H2, CASZ1, ATM, NOX4, GPR162, SIGLEC7, POLDIP2, RNF19A, SUMF2, THBS1, TGFBR3, CD34, CD44, NOTCH3, NOTCH1, NOS3, CSF2, NF1, MYBPC3, MTHFR, VCAN, DECR1, MMP13, MMP12, EPHB2, MMP3, FXN, MFAP4, MFAP1, MET, CCN1, LAMC2, MAPK14, PLXNA2, CRP, SLN, TGFBI, TGFB3, CDH5, CNN1, COL1A1, SULT1E1, COL2A1, COX8A, SLC12A3, CRK, SLC3A1, SCD, ACSM3, ROS1, REN, PTGS2, MAP2K7, ACTB, MTCO2P12
    • Marfan Syndrome OMIM
      A number sign (#) is used with this entry because all cases of the Marfan syndrome appear to be due to heterozygous mutation in the fibrillin-1 gene (FBN1; 134797) on chromosome 15q21. Description A heritable disorder of fibrous connective tissue, Marfan syndrome shows striking pleiotropism and clinical variability. The cardinal features occur in 3 systems--skeletal, ocular, and cardiovascular (McKusick, 1972; Pyeritz and McKusick, 1979; Pyeritz, 1993). It shares overlapping features with congenital contractural arachnodactyly (121050), which is caused by mutation in the FBN2 gene (612570). Gray and Davies (1996) gave a general review. They published Kaplan-Meier survival curves for a cohort of British Marfan syndrome patients demonstrating greater survivorship in females than in males; a similar result had been reported by Murdoch et al. (1972) and by Silverman et al. (1995).
    • Marfan Syndrome Orphanet
      Marfan syndrome is a systemic disease of connective tissue characterized by a variable combination of cardiovascular, musculo-skeletal, ophthalmic and pulmonary manifestations. Epidemiology The prevalence is estimated at 1/5,000 and there is no difference between sexes. Clinical description Symptoms can appear at any age and vary greatly between individuals even within the same family. Cardiovascular involvement is characterized by 1) progressive dilation of the aorta accompanied by an increased risk of aortic dissection, which affects prognosis; the aortic dilation can result in a leaky aortic valve; and 2) mitral insufficiency, which can be complicated by arythmias, endocarditis or cardiac insufficiency. Skeletal involvement is often the first sign of the disease and can include dolichostenomelia (excessive length of extremities), large size, arachnodactyly, joint hypermobility, scoliotic deformations, acetabulum protrusion, thoracic deformity (pectus carinatum or pectus excavatum), dolichocephaly of the anteroposterior axis, micrognathism or malar hypoplasia.
    • Marfan Syndrome GARD
      Marfan syndrome is a disorder of the connective tissue. Connective tissue provides strength and flexibility to structures throughout the body such as bones, ligaments, muscles, walls of blood vessels, and heart valves. Marfan syndrome affects most organs and tissues, especially the skeleton, lungs, eyes, heart, and the large blood vessel that distributes blood from the heart to the rest of the body (the aorta). It is caused by mutations in the FBN1 gene, which provides instructions for making a protein called fibrillin-1. Marfan syndrome is inherited in an autosomal dominant pattern. At least 25% of cases are due to a new ( de novo ) mutation. Treatment is based on the signs and symptoms in each person.
    • Marfan Syndrome GeneReviews
      Summary Clinical characteristics. Marfan syndrome, a systemic disorder of connective tissue with a high degree of clinical variability, comprises a broad phenotypic continuum ranging from mild (features of Marfan syndrome in one or a few systems) to severe and rapidly progressive neonatal multiorgan disease. Cardinal manifestations involve the ocular, skeletal, and cardiovascular systems. Ocular findings include myopia (the most common ocular feature); ectopia lentis (seen in approximately 60% of affected individuals); and an increased risk for retinal detachment, glaucoma, and early cataracts. Skeletal system manifestations include bone overgrowth and joint laxity; disproportionately long extremities for the size of the trunk (dolichostenomelia); overgrowth of the ribs that can push the sternum in (pectus excavatum) or out (pectus carinatum); and scoliosis that ranges from mild to severe and progressive. The major morbidity and early mortality in the Marfan syndrome relate to the cardiovascular system and include dilatation of the aorta at the level of the sinuses of Valsalva (predisposing to aortic tear and rupture), mitral valve prolapse with or without regurgitation, tricuspid valve prolapse, and enlargement of the proximal pulmonary artery.
    • Marfan Syndrome MedlinePlus
      Marfan syndrome is a disorder that affects the connective tissue in many parts of the body. Connective tissue provides strength and flexibility to structures such as bones, ligaments, muscles, blood vessels , and heart valves . The signs and symptoms of Marfan syndrome vary widely in severity, timing of onset, and rate of progression. Because connective tissue is found throughout the body, Marfan syndrome can affect many systems, often causing abnormalities in the heart, blood vessels, eyes, bones, and joints. The two primary features of Marfan syndrome are vision problems caused by a dislocated lens (ectopia lentis ) in one or both eyes and defects in the large blood vessel that distributes blood from the heart to the rest of the body (the aorta ).
    • Marfan Syndrome Mayo Clinic
      Overview Marfan syndrome is an inherited disorder that affects connective tissue — the fibers that support and anchor your organs and other structures in your body. Marfan syndrome most commonly affects the heart, eyes, blood vessels and skeleton. People with Marfan syndrome are usually tall and thin with unusually long arms, legs, fingers and toes. The damage caused by Marfan syndrome can be mild or severe. If your aorta — the large blood vessel that carries blood from your heart to the rest of your body — is affected, the condition can become life-threatening. Treatment usually includes medications to keep your blood pressure low to reduce the strain on your aorta.
  • Delayed Puberty Wikipedia
    Children residing closer to the equator, at lower altitudes, in cities and other urban areas generally begin the process of puberty earlier than their counterparts. [7] Mildly obese to morbidly obese children are also more likely to begin puberty earlier than children of normal weight. [11] Variation in genes related to obesity such as FTO or NEGRI have been associated with earlier onset of puberty. [7] Children whose parents started puberty at an earlier age were also more likely to experience it themselves, especially in women where onset of menstruation correlated well between mothers and daughters and between sisters. [7] Causes [ edit ] Pubertal delay can be separated into four categories from most to least common: [2] Constitutional and physiologic delay [ edit ] Children who are healthy but have a slower rate of physical development than average have a constitutional delay with a subsequent delay in puberty.
    IGFALS, KISS1R, KISS1, LEPR, LHB, CRH, BSCL2, FGFR1, DEAF1, RAI1, SEMA3A, PNPLA6, ZMPSTE24, MKRN3-AS1, POLR3A, RPL35, NR0B1, RAB18, RAB3GAP1, HS6ST1, IQSEC2, ZFPM2, GPR161, SPIDR, NPAP1, FLRT3, RAB3GAP2, NIPBL, SEMA3E, BMP15, TRIP4, SMC3, SOX3, SOX9, SOX10, SRY, STAT1, VAMP7, TAC3, TACR3, TAF13, TBX3, TGFB1, WFS1, WT1, MKRN3, USP9X, SMC1A, CUL4B, HESX1, FGF17, HERC2, AIP, NSMF, YARS2, PSMC3IP, NLRP3, DCAF17, PUS1, ASXL3, SPRY4, LAS1L, PHF6, PPP1R15B, LHX4, TSR2, TBC1D20, CDON, PROKR2, PWAR1, VPS13B, CCDC141, SNORD115-1, FEZF1, CISD2, UBA6-AS1, PWRN1, POF1B, CDH23, PROK2, ALX4, GMNN, SMPD1, PHF21A, DACT1, WWOX, ADA2, MAGEL2, IL17RD, RBM28, SETD5, ATAD3A, SLC29A3, CHD7, POLR3B, WDR11, HDAC8, MRPS22, NUP107, DMRT3, SNRPN, SALL1, SLC12A3, HLA-DQB1, GBA, GHR, GHSR, GLA, GLI2, GNRH1, GNRHR, HBB, HLA-DQA1, HSD3B2, GATA1, INSR, IPW, ANOS1, LMNA, MAP3K1, MEN1, KMT2A, MMP1, COX1, GATA4, SLC37A4, MSMO1, CYP11A1, ATM, BRAF, SCARB2, ENTPD1, CLCNKB, COL7A1, CTNS, CTNNB1, CYB5A, CYP17A1, G6PC, DCC, DUSP6, EIF2S3, EXT2, FGD1, FGF8, FLII, FSHR, NR5A1, COX2, COX3, ND1, RPS7, RAD21, ROBO1, RPL5, RPL11, RPL15, RPL18, RPL26, RPL27, RPL35A, RPS10, ND4, RPS15A, RPS17, RPS19, RPS24, RPS26, RPS27, RPS28, RPS29, ALDOA, PTPN11, PROP1, POU1F1, POR, ND5, ND6, TRNF, TRNH, TRNL1, TRNQ, TRNS1, TRNS2, TRNW, NDN, NDP, NONO, NOTCH2, OCRL, OTX2, PCSK1, PGM1, PHKG2, POMC, SNORD116-1
  • Thrombosis Wikipedia
    "The Relationship Between Ambient Air Pollution and Acute Ischemic Stroke: A Time-Stratified Case-Crossover Study in a City-State With Seasonal Exposure to the Southeast Asian Haze Problem".
    F2, SERPINC1, P2RY12, PLAU, FGA, F5, F3, PROC, VWF, SERPINE1, PROCR, SELP, PLAT, ADAMTS13, PROS1, TNF, PF4, FCGR2A, PTGS2, THBD, VHL, CRP, MERTK, GAS6, GP1BA, PDE3A, P2RY1, AGT, PTGER3, PODXL, HMOX1, TYRO3, KLF4, SIRT1, VKORC1, KLKB1, MAS1, HGF, FUT4, BDKRB2, CD2, CYP2C19, CYP3A5, EPO, F9, F10, FLT3, BCRP3, GUCY1A1, APOH, CD40LG, TBXAS1, C5AR1, PIK3CB, ACE2, JAK2, MTHFR, NOS3, ITGA2, ITGB3, CPB2, VASP, TFPI, F8, P2RX1, MPL, TNFSF14, SCUBE2, CD177, GP6, C1QBP, C4B, IL1B, SCUBE1, TUBB1, IL6, KLF2, MRVI1, CANT1, LPA, DCN, PLA2G6, F11, LEPR, LEP, FGG, PECAM1, FGB, F13A1, PTGS1, ITGA2B, ICAM4, EGR1, SLC19A1, TBXA2R, ANXA5, CD55, ENG
  • West Nile Fever Wikipedia
    The American outbreak began in College Point, Queens in New York City and was later spread to the neighboring states of New Jersey and Connecticut . ... PMID 16230476 . ^ Glass, WG; McDermott DH; Lim JK; Lekhong S; Yu SF; Frank WA; Pape J; Cheshier RC; Murphy PM (January 23, 2006). ... S2CID 37751889 . ^ "2012 DOHMH Advisory #8: West Nile Virus" (PDF) . New York City Department of Health and Mental Hygiene. ... Archived from the original on 2013-04-15. ^ Oklahoma State University : Mosquitoes and West Nile virus ^ Benedict MQ, Levine RS, Hawley WA, Lounibos LP (2007). "Spread of the tiger: global risk of invasion by the mosquito Aedes albopictus " . ... "The outbreak of West Nile virus infection in the New York City area in 1999" . N. Engl. J. Med . 344 (24): 1807–14. doi : 10.1056/NEJM200106143442401 .
    CCR5, ERVK-32, ROBO3, MAVS, DDX58, PLAAT4, IFIT2, ERVK-6, STAT1, SPP1, OAS1, IL1B, IFNB1, RNASEL, CASP8, HLA-DRB1, PELI1, SELENBP1, ARHGEF2, LRRFIP1, NAMPT, TRAIP, RIPK3, SEC14L2, CSF1R, LAMP3, ERVW-1, FOXP3, ZMYND10, DDX56, CCR7, VCP, CDKN2A, IFIH1, DHX58, ZBP1, HAVCR2, PIK3IP1, NLRP3, TNFRSF13C, TRIM6, RBM45, CCR2, ERVK-20, ERVK-18, VAMP8, TNFRSF1A, IFNA1, TNF, IFNA13, HLA-DQA1, IL1A, HLA-C, IL10, IL17A, IL18, IRF3, IRF5, KIR2DL2, KIR3DL1, KIR3DS1, LSAMP, CD180, SMAD4, MMP9, HLA-A, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PZP, GLS, CASP1, SNCA, GEM, DDX3X, TAP1, TLR3, ATF4
  • Panic Attack Wikipedia
    The term "agora" refers to the place where ancient Greeks used to gather and talk about issues of the city, so it applies to any or all public places; however, the essence of agoraphobia is a fear of panic attacks especially if they occur in public as the victim may feel like he or she has no escape.
    ADORA2A, ADRA2A, CCKBR, COMT, INS, DNAJC6, SDHC, SDHD, SNCA, TP53, UCHL1, VHL, SLC25A11, SGCE, KIF1B, PARK7, RET, SPART, CIZ1, HTRA2, VPS13C, SDHAF2, TMEM127, PINK1, KCTD17, LRRK2, SDHA, SDHB, SLC25A42, PODXL, PRKN, MDH2, DLST, DRD2, MAX, TOR1A, FH, CCK, PTK7, HTR1A, KRT7, MAOA, TAL1, SCLY, CYP2D6, COPD, TPH2, AGT, DST, DUSP26, SLC6A1, ACE, DBI, IGFBP2, SLC6A4, SNAP25, LEP, HCRTR1, GLO1
  • Postpartum Depression Wikipedia
    Recent findings have also identified blunted activity in anterior cingulate cortex, striatum , orbitofrontal cortex , and insula in mothers with PPD when viewing images of their own infants. [18] More robust studies on neural activation regarding PPD have been conducted with rodents than humans and has allowed for greater isolation of specific brain regions, neurotransmitters , hormones , and steroids . [18] [19] Onset and duration [ edit ] Postpartum depression onset usually begins between two weeks to a month after delivery. [20] A study done at an inner-city mental health clinic has shown that 50% of postpartum depressive episodes there began prior to delivery. [21] Therefore, in the DSM-5 postpartum depression is diagnosed under "depressive disorder with peripartum onset", in which "peripartum onset" is defined as anytime either during pregnancy or within the four weeks following delivery. ... "Onset and persistence of postpartum depression in an inner-city maternal health clinic system". The American Journal of Psychiatry . 158 (11): 1856–63. doi : 10.1176/appi.ajp.158.11.1856 .
    SLC6A4, TTC9B, HP1BP3, HTR1A, OPRM1, PER2, MTHFR, GABRD, IL10, OXTR, TPO, BDNF, SAGE1, NR3C1, CCN6, ADIPOQ, FHL5, ACOT7, PART1, MARCHF11, AGO2, POTEKP, TAL1, SCLY, ARID4B, KRT88P, CREB3L1, POTEM, COPD, ACTBL2, VSX1, SERPINA3, PRL, ABO, ACTG1, ACTG2, ATP5F1A, OPN1SW, TSPO, SERPINA6, CRH, CRP, EGR3, ESR1, GALR1, GATA3, HPD, HSD11B1, IL6, KRT7, NR3C2, MPI, NPPA, STIN2-VNTR
    • Postpartum Depression Mayo Clinic
      Overview The birth of a baby can start a variety of powerful emotions, from excitement and joy to fear and anxiety. But it can also result in something you might not expect — depression. Most new moms experience postpartum "baby blues" after childbirth, which commonly include mood swings, crying spells, anxiety and difficulty sleeping. Baby blues usually begin within the first 2 to 3 days after delivery and may last for up to two weeks. But some new moms experience a more severe, long-lasting form of depression known as postpartum depression.
  • Diphtheria Wikipedia
    Nora Wattie Principal Medical Officer (Maternity and Child Welfare) introduced immunisation clinics across Glasgow , and promoted mother and child health education, resulting in virtual eradication of the infection in the city. [52] In 1943, diphtheria outbreaks accompanied war and disruption in Europe.
    EGF, PPP1R42, IL2, TOX, ITGAM, ITGAX, HBEGF, CSF2, IL3, FOXP3, IL3RA, IL13, PRDX2, CARD14, CD207, ABCB6, C4BPA, PRNP, LGR5, IL2RA, EEF2, HSPA4, CCR2, IGF2, VEGFA, EGFR, ISG20, LYZ, SIGLEC1, H19, PLAUR, POMC, AFP, CLEC9A, EPX, HSP90AA1, CD19, HCRT, ATN1, RAD51, TNF, GCG, MRC1, PPIL1, GLP1R, TEK, TBCA, TERC, TAT, SFTPC, TG, XRCC2, APOL1, SST, UCP1, TRAF6, TP53, NPHS2, ABL1, FADD, RECQL4, LINC01672, ZGLP1, SNORD116@, SLC26A5, GSTK1, SLC35D3, GCNT7, ZBTB46, SLCO6A1, KRT71, SFXN1, TSLP, EHMT1, PTCPRN, TSPYL2, PLXNA3, ENOSF1, SAGE1, FEV, CD274, BHLHE22, HPGDS, MSLN, FARP2, SNCAIP, RAG1, MUC1, PTPRC, COL11A2, FOXO1, FOXD1, FGF2, FCGR1A, F11, F2R, DPH2, DMP1, CX3CR1, CSF3, CSF2RA, CSF1R, CCR4, GCNT1, CDKN2A, CD40, CD1D, CAV2, CASP8, CASP3, ATP6V0B, KLK3, APP, ANK1, ALB, AGRP, GCGR, GFAP, PTN, MAP6, PIK3CA, ENPP3, PAX3, P4HB, NPHS1, NPY, NOTCH1, NFATC1, MMUT, PARP1, MOG, MECP2, LGALS4, GH1, JAK3, ITIH4, IL7, IL4, IGHG3, IFNA13, IFNA1, HDC, GRP, GPT, GPI, GLB1, H3P10
    • Diphtheria Orphanet
      A rare bacterial infectious disease characterized by an affliction of the upper respiratory tract mediated by the toxin of Corynebacterium diphtheriae . Symptoms include formation of an inflammatory pseudomembrane, fever, sore throat, headaches, coughing, dysphagia, dyspnea, and prominently swollen cervical lymph nodes. The disease may lead to respiratory failure and severe toxin-mediated damage of internal organs, including the heart and kidneys. A cutaneous form of diphtheria is more common in tropical climates and usually follows an indolent course.
    • Diphtheria Mayo Clinic
      Overview Diphtheria (dif-THEER-e-uh) is a serious bacterial infection that usually affects the mucous membranes of the nose and throat. Diphtheria is extremely rare in the United States and other developed countries thanks to widespread vaccination against the disease. However, many countries with limited health care or vaccination options still experience high rates of diphtheria. Diphtheria can be treated with medications. But in advanced stages, diphtheria can damage the heart, kidneys and nervous system. Even with treatment, diphtheria can be deadly, especially in children.
  • Rickets Wikipedia
    Persistent thick fog and heavy industrial smog permeating the city blocked out significant amounts of sunlight to such an extent that up to 80 percent of children at one time had varying degrees of rickets in one form or the other. [ citation needed ] It is sometimes known "the English Disease" in some foreign languages (e.g.
    CYP27B1, VDR, FAM20C, CYP3A4, SMS, TRPV5, RSS
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