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  • Multiple Drug Resistance Wikipedia
    A microbial organism's resistance to multiple antimicrobial drugs or a cancer cell's resistance to multiple cytostatics This article is about multiple drug resistance in microorganisms. For multiple drug resistance in tumor/cancer cells, see antineoplastic resistance . ... "Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America" . ... Drugs . 69 (12): 1555–623. doi : 10.2165/11317030-000000000-00000 . ... Pakistan at the verge of potential epidemics by multi-drug resistant pathogenic bacteria (2015).
  • Mixed Transcortical Aphasia Wikipedia
    International Encyclopedia of Rehabilitation. Available online: http://cirrie.buffalo.edu/encyclopedia/en/article/9/#s10 ^ Berthier, Marcelo L.; Starkstein, Sergio E.; Leiguarda, Ramon; Ruiz, Adelaida; Mayberg, Helen S.; Wagner, Henry; Price, Thomas R.; Robinson, Robert G. (1991). ... St Louis, Mo: Mosby/Elsevier. Retrieved March 22, 2015, from: https://books.google.com/books?id=wM9sBQAAQBAJ&pg=PA198 ^ Nussbaum, P. (1997). ... New York: Plenum Press. Retrieved March 22, 2015 from https://books.google.com/books?id=QxR6EaATaUwC&pg=PA545 ^ LaPointe, L (2005). ... New York: Thieme. Retrieved March 22, 2015, from https://books.google.com/books?id=PgRbFxayeQwC&pg=PA181 ^ a b LaPointe, L (2005). ... New York: Thieme. Retrieved March 22, 2015, from https://books.google.com/books?id=PgRbFxayeQwC&pg=PA181 ^ a b c d e f g Farias, et al, (2006).
  • Abortion In Portugal Wikipedia
    Abortion laws in Portugal were liberalized on April 10, 2007, allowing the procedure to be performed on-demand if a woman's pregnancy has not exceeded its tenth week. [1] There is a three-day waiting period for abortions. [2] President Aníbal Cavaco Silva ratified the law allowing abortion, recommending nevertheless that measures should be taken to ensure abortion is the last resort. [3] Despite the liberalization of the laws, as of a 2011 survey, many doctors were refusing to perform abortions – which they are allowed to do under a conscientious objection clause . [4] Abortions at later stages are allowed for specific reasons, such as risk to woman's health reasons, rape and other sexual crimes, or fetal malformation; with restrictions increasing gradually at 12, 16 and 24 weeks. [5] Contents 1 History and progression of legislation 1.1 Laws previous to the carnation revolution 1.2 Carnation revolution and first exception law 1.3 From the 1998 referendum to legalization 1.4 Post legalization 2 Prevalence 3 References History and progression of legislation [ edit ] Laws previous to the carnation revolution [ edit ] Abortion was established as illegal in Sebastian of Portugal 's Regimento de Quadrilheiros (1570), during the Aviz dynasty period. [6] This law was then transposed, with little change, to Philip I of Portugal 's Ordenações Filipinas , during the Iberian Union period. [6] During the Constitutional Monarchy , the article 358 of the Penal Code of Portugal (1852) defined and prohibited abortion, which was punished with time in prison and considered, as a mitigating factor , abortions that were done to hide the dishonor of the mother. [6] The Penal Code of 1886 transposed, with little change, the abortion law of 1852. [6] During the Estado Novo , the 358 article of the 1886 Penal Code was still in force. A law in 1927 ( Decreto de Lei 13/470 ) regulated medication abortion by requiring medical prescription. [6] Another law ( Decreto de Lei 17/636 ), in 1929, prohibited the sale, without medical prescription, and advertising of any substance that had abortion as its off-label use . [6] In 1942, a new law extended these limitations to any medical accessory that could be used to cause abortion. [6] Carnation revolution and first exception law [ edit ] After the Carnation Revolution , the Portuguese Constitution of 1976 mentioned family planning as a right (67th article), but made no reference to abortion. [6] Abortion begins to be publicly discussed after a news report called "Abortion is not a Crime" that aired in 4 February 1976 in RTP , by reporter Antónia Palla, after which multiple organizations voiced their opinions towards the subject. [6] In 1979, the Socialist Party , Portuguese Communist Party , and Popular Democratic Union parties announce their intentions to propose laws to legalize abortion, as a result of the polemic juridical cases of Antónia Palla (sued due to the "Abortion is not a crime" news report, but acquitted) and Conceição Massano (a 22 year old woman who had been anonymously reported to the authorities as having committed an abortion). [6] The Popular Democratic Union (1980) and the Democratic and Socialist Left Union (1982) would present abortion bills that did not make it to the Assembly floor. [6] The Portuguese Communist Party, in 1982, managed to get their abortion bill to the Assembly. [6] The Penal Code of 1983 contained an abortion law similar to the Penal Code of 1886, including the mitigating factor of dishonor. [6] In 1984, the Socialist Party passed a law that allowed abortion in specific cases: in the case of mental or physical health reasons, rape and sexual crimes, and fetal malformation. [5] [6] This would be the first time, in Portugal, that a law exempted abortion from punishment in certain situations. [7] In 1997, a new law increased the period in which abortion could be conducted when there was fetal malformation (from 16 to 24 weeks) and in case of rape (from 12 to 16). [6] Although, when these two laws were in force, the abortion laws in Portugal were relatively similar to those of neighboring Spain, in practice, the law was given a much stricter interpretation in Portugal than in Spain, and obtaining a legal abortion was quite difficult. [8] [6] From the 1998 referendum to legalization [ edit ] The Socialist Youth would present an abortion legalization bill in 1996 that would fail to be approved by one vote, and another bill in 1998 that would be approved. ... WBEZ . 10 August 2011 . Retrieved 5 May 2020 . ^ a b http://www.spdc.pt/files/publicacoes/Pub_AbortionlegislationinEuropeIPPFEN_Feb2009.pdf ^ a b c d e f g h i j k l m n o p q r s t u Baptista, Maria Isabel Rodrigues (2018-09-13). ... Retrieved 2020-08-22 . ^ "Iniciativa ″Direito a Nascer″ baixou à comissão de forma ilegal - JN" . www.jn.pt (in Portuguese) . Retrieved 2020-08-22 . ^ https://abcnews.go.com/Health/wireStory/portugal-lawmakers-overturn-veto-gay-rights-abortion-law-36836277 ^ "Cavaco promulgou adoção gay e alterações à lei do aborto" . ... Retrieved 3 March 2014 . v t e Abortion in Europe Sovereign states Albania Andorra Armenia Austria Azerbaijan Belarus Belgium Bosnia and Herzegovina Bulgaria Croatia Cyprus Czech Republic Denmark Estonia Finland France Georgia Germany Greece Hungary Iceland Ireland Italy Kazakhstan Latvia Liechtenstein Lithuania Luxembourg Malta Moldova Monaco Montenegro Netherlands North Macedonia Norway Poland Portugal Romania Russia San Marino Serbia Slovakia Slovenia Spain Sweden Switzerland Turkey Ukraine United Kingdom England Northern Ireland Scotland Wales Vatican City States with limited recognition Abkhazia Artsakh Kosovo Northern Cyprus South Ossetia Transnistria v t e Abortion Main topics Definitions History Methods Abortion debate Philosophical aspects Abortion law Movements Abortion-rights movements Anti-abortion movements Issues Abortion and mental health Beginning of human personhood Beginning of pregnancy controversy Abortion-breast cancer hypothesis Anti-abortion violence Abortion under communism Birth control Crisis pregnancy center Ethical aspects of abortion Eugenics Fetal rights Forced abortion Genetics and abortion Late-term abortion Legalized abortion and crime effect Libertarian perspectives on abortion Limit of viability Malthusianism Men's rights Minors and abortion Natalism One-child policy Paternal rights and abortion Prenatal development Reproductive rights Self-induced abortion Sex-selective abortion Sidewalk counseling Societal attitudes towards abortion Socialism Toxic abortion Unsafe abortion Women's rights By country Africa Algeria Angola Benin Botswana Burkina Faso Burundi Cameroon Cape Verde Central African Republic Chad Egypt Ghana Kenya Namibia Nigeria South Africa Uganda Zimbabwe Asia Afghanistan Armenia Azerbaijan Bahrain Bangladesh Bhutan Brunei Cambodia China Cyprus East Timor Georgia India Iran Israel Japan Kazakhstan South Korea Malaysia Nepal Northern Cyprus Philippines Qatar Saudi Arabia Singapore Turkey United Arab Emirates Vietnam Yemen Europe Albania Andorra Austria Belarus Belgium Bosnia and Herzegovina Bulgaria Croatia Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland Ireland Italy Kazakhstan Latvia Liechtenstein Lithuania Luxembourg Malta Moldova Monaco Montenegro Netherlands North Macedonia Norway Poland Portugal Romania Russia San Marino Serbia Slovakia Slovenia Spain Sweden Switzerland Ukraine United Kingdom North America Belize Canada Costa Rica Cuba Dominican Republic El Salvador Guatemala Mexico Nicaragua Panama Trinidad and Tobago United States Oceania Australia Micronesia Fiji Kiribati Marshall Islands New Zealand Papua New Guinea Samoa Solomon Islands Tonga Tuvalu Vanuatu South America Argentina Bolivia Brazil Chile Colombia Ecuador Guyana Paraguay Peru Suriname Uruguay Venezuela Law Case law Constitutional law History of abortion law Laws by country Buffer zones Conscientious objection Fetal protection Heartbeat bills Informed consent Late-term restrictions Parental involvement Spousal consent Methods Vacuum aspiration Dilation and evacuation Dilation and curettage Intact D&X Hysterotomy Instillation Menstrual extraction Abortifacient drugs Methotrexate Mifepristone Misoprostol Oxytocin Self-induced abortion Unsafe abortion Religion Buddhism Christianity Catholicism Hinduism Islam Judaism Scientology Category
  • Marker Chromosome Wikipedia
    A marker can be composed of inactive genetic material and have little or no effect, or it can carry active genes and cause genetic conditions such as iso(12p), which is associated with Pallister-Killian syndrome , and iso(18p) , which is associated with mental retardation and syndromic facies . [3] Chromosome 15 has been observed to contribute to a high number of marker chromosomes, but the reason has not been determined. [1] References [ edit ] ^ a b Thompson & Thompson Genetics in Medicine, Chapter 5, 57-74 https://www.clinicalkey.com/#! ... scrollTo=%23hl0000654 ^ a b Nelson Textbook of Pediatrics, Chapter 81, 604-627 https://www.clinicalkey.com/#!/content/book/3-s2.0-B9781455775668000818? ... American Journal of Human Genetics . 82 : 398–410. doi : 10.1016/j.ajhg.2007.10.013 . PMC 2427313 . PMID 18252220 . https://web.archive.org/web/20060926021351/http://www.chromodisorder.org/sytrix/card_list.php3?
  • Cancer In Dogs Wikipedia
    Survival rates have also increased due to the increased prevalence of canine cancer treatment centers and breakthroughs in targeted drug development. Canine cancer treatment has become an accepted clinical practice and access to treatment for owners has widely expanded recently. [2] Cancer-targeting drugs most commonly function to inhibit excessive cell proliferation by attacking the replicating cells. [4] There is one canine tumor vaccine approved by the USDA , for preventing canine melanoma. [6] The Oncept vaccine activates T-cell responses and antibodies against tumor-specific tyrosinase proteins. [6] There is limited information about canine tumor antigens, which is the reason for the lack of tumor-specific vaccines and immunotherapy treatment plans for dogs. [6] Success of treatment depends on the form and extent of the cancer and the aggressiveness of the therapy. ... The heterogeneity of tumors makes drug development increasingly complex, especially as new causes are discovered. ... There are a variety of theories aimed to explain the reasoning behind these occurrences, but here are two. ... The Veterinary Journal . 207 : 20–8. doi : 10.1016/j.tvjl.2015.10.008 . PMID 26545847 . ^ https://www.bluecross.org.uk/pet-advice/coping-cancer-dogs External links [ edit ] Cancer in Dogs: Symptoms, Diagnosis and Treatment from Pet Education [1] from Understanding Cancer in Golden Retrievers
  • Abortion In Ecuador Wikipedia
    In Ecuador, there is strong political opposition to abortion; in 2013 then president Rafael Correa threatened to resign if the abortion law was liberalized. [2] As of 2015, nearly 100 criminal cases of illegal abortion were under investigation. [3] In 2015, Ecuador was urged by CEDAW to decriminalize abortion in cases of rape and incest (under current law abortion in this case is legal only if the woman is mentally disabled) and severe fetal impairment (which is also illegal). [4] See also [ edit ] Abortion Abortion by country Abortion law References [ edit ] ^ http://www.womenonwaves.org/en/page/4944/ecuador--abortion-law ^ https://www.bbc.com/news/world-latin-america-24499248 ^ https://www.hrw.org/news/2015/04/22/ecuador-adopt-un-recommendations-abortion-law ^ https://www.hrw.org/news/2015/04/22/ecuador-adopt-un-recommendations-abortion-law [1] [2] v t e Abortion in South America Sovereign states Argentina Bolivia Brazil Chile Colombia Ecuador Guyana Paraguay Peru Suriname Uruguay Venezuela Dependencies and other territories Falkland Islands French Guiana South Georgia and the South Sandwich Islands v t e Abortion Main topics Definitions History Methods Abortion debate Philosophical aspects Abortion law Movements Abortion-rights movements Anti-abortion movements Issues Abortion and mental health Beginning of human personhood Beginning of pregnancy controversy Abortion-breast cancer hypothesis Anti-abortion violence Abortion under communism Birth control Crisis pregnancy center Ethical aspects of abortion Eugenics Fetal rights Forced abortion Genetics and abortion Late-term abortion Legalized abortion and crime effect Libertarian perspectives on abortion Limit of viability Malthusianism Men's rights Minors and abortion Natalism One-child policy Paternal rights and abortion Prenatal development Reproductive rights Self-induced abortion Sex-selective abortion Sidewalk counseling Societal attitudes towards abortion Socialism Toxic abortion Unsafe abortion Women's rights By country Africa Algeria Angola Benin Botswana Burkina Faso Burundi Cameroon Cape Verde Central African Republic Chad Egypt Ghana Kenya Namibia Nigeria South Africa Uganda Zimbabwe Asia Afghanistan Armenia Azerbaijan Bahrain Bangladesh Bhutan Brunei Cambodia China Cyprus East Timor Georgia India Iran Israel Japan Kazakhstan South Korea Malaysia Nepal Northern Cyprus Philippines Qatar Saudi Arabia Singapore Turkey United Arab Emirates Vietnam Yemen Europe Albania Andorra Austria Belarus Belgium Bosnia and Herzegovina Bulgaria Croatia Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland Ireland Italy Kazakhstan Latvia Liechtenstein Lithuania Luxembourg Malta Moldova Monaco Montenegro Netherlands North Macedonia Norway Poland Portugal Romania Russia San Marino Serbia Slovakia Slovenia Spain Sweden Switzerland Ukraine United Kingdom North America Belize Canada Costa Rica Cuba Dominican Republic El Salvador Guatemala Mexico Nicaragua Panama Trinidad and Tobago United States Oceania Australia Micronesia Fiji Kiribati Marshall Islands New Zealand Papua New Guinea Samoa Solomon Islands Tonga Tuvalu Vanuatu South America Argentina Bolivia Brazil Chile Colombia Ecuador Guyana Paraguay Peru Suriname Uruguay Venezuela Law Case law Constitutional law History of abortion law Laws by country Buffer zones Conscientious objection Fetal protection Heartbeat bills Informed consent Late-term restrictions Parental involvement Spousal consent Methods Vacuum aspiration Dilation and evacuation Dilation and curettage Intact D&X Hysterotomy Instillation Menstrual extraction Abortifacient drugs Methotrexate Mifepristone Misoprostol Oxytocin Self-induced abortion Unsafe abortion Religion Buddhism Christianity Catholicism Hinduism Islam Judaism Scientology Category ^ https://aplicaciones.msp.gob.ec/salud/archivosdigitales/documentosDirecciones/dnn/archivos/ac_00005195_2014%2020%20nov.pdf ^ http://www.womenonwaves.org/article-1572-en.html
  • Myasthenia Gravis With Thymus Hyperplasia Omim
    This haplotype is associated with highly prevalent autoimmune diseases (Price et al., 1999). Vandiedonck et al. (2004) localized the MYAS1 gene to a 1.2-Mb genome segment by reconstructing haplotypes and assessing their transmission in 73 simplex families.
    CFB, HLA-B, MUSK, HLA-DPB1, POMC, FAS, HLA-DRB1, HLA-DQA1, PTPN22, HLA-A, TNIP1, C2, IL10, NFKBIL1, ZNRD1, MUC21, SFTA2, HCG9, PSORS1C1, CTLA4, NOTCH4, MUCL3, CYP21A2, RBM45, BTNL2, GPSM3, MSH5, TSBP1, MICB, LRP4, TRIM31, POU5F1, HLA-DQA2, RNF39, GABBR1, VARS2, LINC00243, ABCF1, IFNG, MSH5-SAPCD1, HCG17, TNFRSF11A, TCF19, BCHE, ATP6V1G2, STK19, TNF, HCG18, GPANK1, SEMA5A, TTN, TSBP1-AS1, RBBP8, ACHE, PRRC2A, CXCL13, IL17A, IL2RA, IL6, ISG20, EIF3K, IL2, FOXP3, AIRE, IL4, CHRNA1, TRBV20OR9-2, HLA-DQB1, THM, LTA, IL1B, CD274, IL22, PDCD1, IL21, TLR9, CHRNE, IL1A, MIR150, AQP4, HT, TGFB1, CDR3, ECD, MIR21, DOK7, TLR4, CD40, TLR3, MBP, CCL21, CHRNA4, TAP2, CXCR4, IGHG3, IFNB1, MAPK1, PDLIM7, IL18R1, IL15, EBI3, IL4R, SMN1, CXCL10, IFNA13, TLR7, TNFRSF13C, FGFR3, MIR146A, ESR1, TSLP, CD40LG, GNAO1, DNMT3B, HLA-DQB2, CAV3, IL23A, MIR125A, ADRB2, IFNA1, IFN1@, HMGB1, C4orf3, DIPK1A, SOCS3, LGI1, MSC, SCO2, CD83, GRAP2, MIR145, MIRLET7C, NTN1, MIR155, PPP6R2, MIR143, MBTPS1, MIR15B, SCFV, LOC102723407, IFNG-AS1, LINC-ROR, C4B_2, C20orf181, TEC, CCR2, DDX39B, MIR653, MIR323B, MIR19B1, MIR338, AIMP2, FOSL1, MIR320A, USO1, TNFRSF25, MIR30E, MALAT1, TNFSF10, DDX39A, RMDN2, MYAS1, CCAR2, RNF19A, CNTNAP2, HIF3A, ROBO3, POLDIP2, IFIH1, IGAN1, B3GAT1, DPYSL5, PART1, RETN, IGHV3-52, TWNK, MSL2, KRT20, ICOS, SLC25A37, VAV1, TMEM109, PPP1R15A, PRSS16, UNC5A, CLEC4C, CDIPT, NXF1, MZB1, TRIM9, AHSA1, IL17F, IL33, TNFSF13B, DDX58, CCR9, FHDC1, LILRB1, FAM136A, SLC7A9, TBC1D9, ICOSLG, SEC14L2, VIP, RAF1, UTRN, CNTFR, CRK, MAPK14, CSF1, CCN2, CTSV, CTSS, CYP3A5, CD55, BRINP1, DCC, DNMT3A, ATN1, TYMP, CTTN, ERBB4, ESR2, FCGR2A, FLNB, FOS, FOSB, CXCR3, GRIA2, GRM2, CXCL1, GZMB, HLA-C, HLA-DOA, HLA-DPA1, HLA-DRB3, CR2, CCR7, HNMT, CCR5, ADCYAP1, AGER, ALB, APOE, APRT, ABCC6, BCL2, TNFRSF17, BDNF, C4A, C4B, C5, CA3, CACNA1S, CALCA, CALCR, CAMP, CASP1, CASP3, CD19, MS4A1, CD28, CD86, CD69, CDS1, CHRNB1, CHRND, CLC, CCR4, HLA-G, HOXD13, TYMS, NTRK1, P2RX7, PAM, PAX7, ABCB1, PMP22, MAPK3, PTPRC, PLAAT4, RELB, S100A8, S100A11, S100B, SCN4A, SCO1, CCL5, CCL17, CCL22, CXCL12, SGCA, SLAMF1, SMN2, SPP1, STAT3, STAT4, TAP1, THBS1, TNFAIP3, TNFSF4, TNFRSF4, OSM, NCAM1, HSPA5, MYOG, IRF8, IFNA2, IFNA17, IFNGR1, IGF1, IGF1R, IGFBP1, IGL, IL1RN, IL2RB, IL7R, IL9, IL12B, IL12RB2, INS, IRF4, ITGAX, JUN, JUNB, JUND, KIT, KRT5, LDLR, LGALS1, LGALS8, LIF, MEFV, MFAP1, MMP10, LOC102724971
    • Myasthenia Gravis Medlineplus
      People can develop myasthenia gravis at any age. For reasons that are unknown, it is most commonly diagnosed in women younger than age 40 and men older than age 60.
    • Myasthenia Gravis Omim
      They concluded that CXCL10/CXCR3 signaling is associated with MG pathogenesis and proposed that CXCL10 and CXCR3 may serve as novel drug targets to treat MG. The CHRNA1 gene (100690) encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis.
    • Myasthenia Gravis Gard
      The condition results from a defect in the transmission of nerve impulses to muscles, which is due to the presence of antibodies against acetylcholine . The exact reason this occurs is not known. Some cases have been linked to tumors in the thymus gland .
    • Myasthenia Gravis Wikipedia
      For instance, the doctor may ask one to look at a fixed point for 30 seconds and to relax the muscles of the forehead, because a person with MG and ptosis of the eyes might be involuntarily using the forehead muscles to compensate for the weakness in the eyelids. [15] The clinical examiner might also try to elicit the "curtain sign" in a person by holding one of the person's eyes open, which in the case of MG will lead the other eye to close. [15] Blood tests [ edit ] If the diagnosis is suspected, serology can be performed: One test is for antibodies against the acetylcholine receptor; [15] the test has a reasonable sensitivity of 80–96%, but in ocular myasthenia, the sensitivity falls to 50%. ... This generally is performed on the eyelids when ptosis is present and is deemed positive if a ≥2-mm rise in the eyelid occurs after the ice is removed. [35] Edrophonium test [ edit ] This test requires the intravenous administration of edrophonium chloride or neostigmine, drugs that block the breakdown of acetylcholine by cholinesterase (acetylcholinesterase inhibitors). [36] This test is no longer typically performed, as its use can lead to life-threatening bradycardia (slow heart rate) which requires immediate emergency attention. [37] Production of edrophonium was discontinued in 2008. [18] Imaging [ edit ] A chest X-ray may identify widening of the mediastinum suggestive of thymoma, but computed tomography or magnetic resonance imaging (MRI) are more sensitive ways to identify thymomas and are generally done for this reason. [38] MRI of the cranium and orbits may also be performed to exclude compressive and inflammatory lesions of the cranial nerves and ocular muscles. [39] Pulmonary function test [ edit ] The forced vital capacity may be monitored at intervals to detect increasing muscular weakness. ... Medication consists mainly of acetylcholinesterase inhibitors to directly improve muscle function and immunosuppressant drugs to reduce the autoimmune process. [42] Thymectomy is a surgical method to treat MG. [43] Medication [ edit ] Neostigmine, chemical structure Azathioprine, chemical structure Worsening may occur with medication such as fluoroquinolones , aminoglycosides , and magnesium. [44] About 10% of people with generalized MG are considered treatment-refractory. [45] Autologous hematopoietic stem cell transplantation (HSCT) is sometimes used in severe, treatment-refractory MG. ... Another medication used for MG, atropine , can reduce the muscarinic side effects of acetylcholinesterase inhibitors. [48] Pyridostigmine is a relatively long-acting drug (when compared to other cholinergic agonists), with a half-life around four hours with relatively few side effects. [49] Generally, it is discontinued in those who are being mechanically ventilated, as it is known to increase the amount of salivary secretions. [49] A few high-quality studies have directly compared cholinesterase inhibitors with other treatments (or placebo); their practical benefit may be such that conducting studies in which they would be withheld from some people would be difficult. [50] Immune suppressants [ edit ] The steroid prednisone might also be used to achieve a better result, but it can lead to the worsening of symptoms for 14 days and takes 6–8 weeks to achieve its maximal effectiveness. [49] Due to the myriad symptoms that steroid treatments can cause, it is not the preferred method of treatment. [49] Other immune suppressing medications may also be used including rituximab . [51] Plasmapheresis and IVIG [ edit ] If the myasthenia is serious (myasthenic crisis), plasmapheresis can be used to remove the putative antibodies from the circulation. ... PMID 25310725 . ^ "Atropine – Myasthenia-gravis medicines and drugs" . NHS Choices. 2014. Archived from the original on 12 July 2015 .
    • Myasthenia Gravis Mayo_clinic
      Overview Myasthenia gravis (my-us-THEE-nee-uh GRAY-vis) causes muscles under your voluntary control to feel weak and get tired quickly. This happens when the communication between nerves and muscles breaks down. There's no cure for myasthenia gravis. Treatment can help with symptoms. These symptoms can include weakness of arm or leg muscles, double vision, drooping eyelids, and problems with speaking, chewing, swallowing and breathing. This disease can affect people of any age, but it's more common in women younger than 40 and in men older than 60.
    • Myasthenia, Limb-Girdle, Autoimmune Omim
      Clinical Features Among 314 patients with classic myasthenia gravis (MG; 254200), Oh and Kuruoglu (1992) found 12 (3.8%) who presented with chronic limb-girdle myasthenia. None of the 12 patients had oculobulbar involvement, which had initially excluded the diagnosis of myasthenia gravis. Disease onset occurred between the ages of 28 and 69 years and was characterized by lower proximal muscle weakness, usually followed by upper proximal muscle weakness. All patients showed a decremental response to repetitive nerve stimulation, and all patients had normal serum creatine kinase. Three patients had thymic hyperplasia, 1 patient had systemic lupus erythematosus (SLE; 152700), and 1 patient had hyperthyroidism.
    • Myasthenia Gravis Orphanet
      These antibodies have been found to play a pathogenic role in all the forms of the disease. MG can also be drug induced (by D-penicillamine, interferon alpha, and bone marrow transplantation).
  • Post Viral Cerebellar Ataxia Wikipedia
    Other imaging tests like EEG (electroencephalographs) and MRI (magnetic resonance imaging) can also be performed to eliminate possible diagnoses of other severe diseases, such as neuroblastoma , drug intoxication, acute labyrinthitis , and metabolic diseases. ... Treatment includes corticosteroids , intravenous immunoglobulin , or plasma exchange therapy. Drug treatment to improve muscle coordination has a low success rate. However, the following drugs may be prescribed: clonazepam , amantadine , gabapentin , or buspirone . ... PMID 16054817 . Further reading [ edit ] http://health.nytimes.com/health/guides/disease/acute-cerebellar-ataxia/overview.html [ full citation needed ] https://web.archive.org/web/20111021044049/http://www.bettermedicine.com/article/cerebellar-ataxia-syndrome/symptoms%7B%7Bfull%7Cdate%3DAugust 2015}} MedlinePlus Encyclopedia : Acute cerebellar ataxia http://www.lifescript.com/Health/A-Z/Conditions_A-Z/Conditions/A/ Acute_cerebellar_ataxia.aspx [ full citation needed ] v t e Symptoms and signs relating to movement and gait Gait Gait abnormality CNS Scissor gait Cerebellar ataxia Festinating gait Marche à petit pas Propulsive gait Stomping gait Spastic gait Magnetic gait Truncal ataxia Muscular Myopathic gait Trendelenburg gait Pigeon gait Steppage gait Antalgic gait Coordination Ataxia Cerebellar ataxia Dysmetria Dysdiadochokinesia Pronator drift Dyssynergia Sensory ataxia Asterixis Abnormal movement Athetosis Tremor Fasciculation Fibrillation Posturing Abnormal posturing Opisthotonus Spasm Trismus Cramp Tetany Myokymia Joint locking Paralysis Flaccid paralysis Spastic paraplegia Spastic diplegia Spastic paraplegia Syndromes Monoplegia Diplegia / Paraplegia Hemiplegia Triplegia Tetraplegia / Quadruplegia General causes Upper motor neuron lesion Lower motor neuron lesion Weakness Hemiparesis Other Rachitic rosary Hyperreflexia Clasp-knife response
  • Membranoproliferative Glomerulonephritis Wikipedia
    It is believed to be associated with the classical complement pathway . [4] Type II [ edit ] See also: Eculizumab § Dense-deposit disease (DDD) Also called recently as ‘C3 nephropathy’ The preferred name is "dense deposit disease." [5] Most cases of dense deposit disease do not show a membranoproliferative pattern. [6] A 2012 review considers DDD to be in a continuum with C3 glomerulonephritis , [7] one reason the use of the type I to type III classification system is falling out of favour. [ citation needed ] Most cases are associated with the dysregulation of the alternative complement pathway . [8] [9] DDD is associated with deposition of complement C3 within the glomeruli with little or no staining for immunoglobulin. ... Diagnosis [ edit ] The GBM is rebuilt on top of the deposits, causing a " tram tracking " appearance under the microscope. [17] Mesangial cellularity is increased. [18] Treatment [ edit ] Primary MPGN is treated with steroids, plasma exchange and other immunosuppressive drugs. Secondary MPGN is treated by treating the associated infection, autoimmune disease or neoplasms. ... Molecular Immunology, 48(14), 1604–1610. http://doi.org/10.1016/j.molimm.2011.04.005/ ^ Swainson CP, Robson JS, Thomson D, MacDonald MK (1983). ... Kidney International, 84(6), 1079–1089. http://doi.org/10.1038/ki.2013.377 ^ Neary JJ, Conlon PJ, Croke D, et al. ... Kidney Dis . 40 (1): e1.1–e1.6. doi : 10.1053/ajkd.2002.33932 . PMID 12087587 . ^ https://www.uptodate.com/contents/clinical-presentation-classification-and-causes-of-membranoproliferative-glomerulonephritis#H455985652 ^ "Membranoproliferative_glomerulonephritis_type_I of the Kidney" .
    CFH, TSLP, ALB, CFB, PON1, DNASE2, C1QA, FN1, EP300, PFN1, IL1B, TGFBR2, CCL2, F5, SPARC, EDN1, MYOC, CCN2, CCR6, CDKN1B, CDK2, PRF1, ANGPT2, CXCR1, LMNB2, SOX18, PGM3, IGAN1, IL6, C3, VWF, CFHR3, ADAMTS13, VTN, VEGFA, THY1, TLR9, CFHR5, TAGLN, AFP, MPO, RIT2, PTEN, PIK3CG, PIK3CD, PIK3CB, PIK3CA, AKT1, MMP9, IGHG3, HRAS, HLA-DRB1, HLA-DQB1, CFHR1, CSF3, CGA, RBM45
    • Cfhr5 Deficiency Omim
      A number sign (#) is used with this entry because CFHR5 deficiency is caused by heterozygous mutation in the CFHR5 gene (608593) on chromosome 1q32. Clinical Features Gale et al. (2010) reported 2 unrelated families with an autosomal dominant form of glomerulonephritis resulting in renal failure. Both families had ancestors from the Troodos mountains of Cyprus. Additional patients of Cypriot origin with a similar disorder were subsequently identified. In all, there were 26 patients from 11 families. All had microscopic hematuria, and many developed macroscopic hematuria following upper respiratory tract infections. Renal biopsies showed glomerulonephritis with C3 (120700) deposits in the subendothelium and mesangium.
    • Primary Membranoproliferative Glomerulonephritis Orphanet
      Membranoproliferative glomerulonephritis (MPGN) is a chronic progressive kidney disorder characterized by glomerular capillary wall structural changes and mesangial cell proliferation leading to nephrotic syndrome, hypocomplementemia, hypertension, proteinuria and end-stage kidney disease. MPGN can be due to either idiopathic (type 1, 2 and 3 MPGN; see these terms) or secondary (associated with infectious and immune complex diseases) causes.
    • Membranoproliferative Glomerulonephritis, X-Linked Omim
      Description Habib et al. (1973) recognized 2 morphologic classes for the glomerular changes seen in patients with mesangiocapillary (membranoproliferative) glomerulonephritis (MPGN). Type I is characterized by double contour appearance of the capillary walls due to mesangial cell interposition, with nonargyrophilic subendothelial deposits which are finely granular on electron microscopy. Type II is characterized by linear dense deposits within the basement membrane and only rare double contours. These 2 types appear to be distinct with no conversion of one type to another on serial biopsy. Strife et al. (1977) described a third variety in which there are not only subendothelial deposits but also numerous subepithelial and intramembranous deposits, associated with replication of the lamina densa and frequently disruption of the whole basement membrane.
  • Podoconiosis Wikipedia
    Using light microscopy, Dr Ernest W Price [23] discovered macrophage cells laden with micro-particles in lymph nodes of the affected extremity. ... Transactions of the Royal Society of Tropical Medicine and Hygiene . 101 (12): 1175–80. doi : 10.1016/j.trstmh.2007.08.013 . PMID 17976670 . ^ a b Price EW (1975). "The mechanism of lymphatic obstruction in endemic elephantiasis of the lower legs". ... PMID 16827714 . ^ Vernon, Gervase (2019). "Dr E W Price, the discoverer of podoconiosis". ... Sage publications: 096777201988840. doi : 10.1177/0967772019888406 . PMID 31735101 . ^ Price EW, Henderson WJ (1978). "The elemental content of lymphatic tissues of barefooted people in Ethiopia, with reference to endemic elephantiasis of the lower legs". Transactions of the Royal Society of Tropical Medicine and Hygiene . 72 (2): 132–6. doi : 10.1016/0035-9203(78)90048-2 . PMID 653784 . ^ Price, Dr E W (1990). Podoconiosis . Oxford: Oxford University Press.
  • Histamine Intolerance Wikipedia
    ] ) may delay the breakdown of histamine, or release histamine in the body. [ citation needed ] Alcohol consumption increases the permeability of the cell membrane and thus lowers the histamine tolerance limit, which is why particularly strong reactions can occur when mixing alcohol and histamine-rich foods (e.g. red wine and cheese). [12] Incompatibility of anti-inflammatory and analgesic medications in persons with histamine intolerance: Anti-inflammatory / analgesic drugs that increase allergen-specific histamine release in allergy sufferers are reaction inducing: List from page 125 in: [8] Active ingredient Drugs containing the active ingredient Mefenamic acid Parkemed Diclofenac Dedolor, Deflamat, Diclo B, Diclobene, Diclomelan, Diclostad, Diclovit, Dolo-Neurobion, Neurofenac, Tratul, Voltaren Indometacin Flexidin, Indobene, Indocid, Indohexal, Indomelan, Idometacin, Indoptol, Luiflex, Ralicid Acetyl salicylic acid Aspirin Anti-inflammatory/analgesic drugs that inhibit the allergen-specific histamine release in people with allergies are not reaction inducing. List from page 126 in: [8] Active ingredient Drugs containing the active ingredient Fenbufen Lederfen Levamisole Ergamisol Ibuprofen Avallone, Brufen, Dismenol new, Dolgit, Ibudol, Ibumetin, Ibupron, Ibuprofen Genericon, Kratalgin, Nurofen, Tabcin, Ubumetin, Urem Contrast agents – X-ray contrast allergy: R. ... "Contrast agents release histamine. The reason why, in most cases, nothing happens when administering contrast media is that most patients have no histamine intolerance. But if a patient reacts, anaphylactic shock is inevitable. "For safety reasons, an antihistamine should always be given to people with histamine intolerance prior to examination with an X-ray contrast medium. ... Figure 1: Mediator release from mast cells Figure 2: Model of genesis of mast cell secretory granules Figure 3: Lipid body biogenesis Table 2: Stimuli-selective mediator release from mast cells ^ Healthline https://www.healthline.com/health/histamine-intolerance#symptoms .
    AOC1
  • Abortion In Venezuela Wikipedia
    Please help to ensure that disputed statements are reliably sourced . ( April 2019 ) ( Learn how and when to remove this template message ) Abortion in Venezuela is currently illegal except in some specific cases outlined in the Venezuelan Constitution. [1] The Latin American/Caribbean region holds one of the highest rates of induced abortion in the world; it is calculated that for every 1,000 live births, there are just over 300 abortions, many of which are illegal and/or clandestine abortions. [2] There is not a clear statistic for Venezuela-specific abortion rates, possibly due to a great majority of the abortions that occur going undocumented. [3] The punishment for a woman who has an abortion for any other reason is a prison sentence lasting anywhere between six months and two years. ... For instance, a three-pack of condoms can cost several weeks’ worth of minimum wage pay, [31] and a box of birth control pills can cost almost a year's worth of pay at the same rate, making them virtually unaffordable for citizens. [32] Sterilization and abortion [ edit ] For most, the high prices of contraceptives force them to resort to abstinence or sterilization. ... This group, along with many others, advocates for ending dangerous clandestine abortion. [33] Similarly, Venezuela's National Constituent Assembly (ANC), formed in July 2017, advocates for the reformation of Venezuela's constitution to include women's right to abort beyond those outlined by the “indications model.” [34] Other efforts to support the movement include the efforts of one group to use a telephone hotline to inform women on how to safely have an abortion. [35] Misoprostol is a drug that can be used to induce labor and cause a medical abortion, which is any abortion done via drug. [36] [37] This hotline provides women with the ability to make an informed decision about proceeding with an abortion. ... Guttmacher Institute . Retrieved 13 November 2018 . ^ https://www.un.org/esa/population/publications/abortion/doc/venezuela.doc ^ Kelly, Annie (2018-08-09). ... See also [ edit ] Abortion Abortion by country Abortion law Crisis in Venezuela Abortion in the United States v t e Abortion in South America Sovereign states Argentina Bolivia Brazil Chile Colombia Ecuador Guyana Paraguay Peru Suriname Uruguay Venezuela Dependencies and other territories Falkland Islands French Guiana South Georgia and the South Sandwich Islands v t e Abortion Main topics Definitions History Methods Abortion debate Philosophical aspects Abortion law Movements Abortion-rights movements Anti-abortion movements Issues Abortion and mental health Beginning of human personhood Beginning of pregnancy controversy Abortion-breast cancer hypothesis Anti-abortion violence Abortion under communism Birth control Crisis pregnancy center Ethical aspects of abortion Eugenics Fetal rights Forced abortion Genetics and abortion Late-term abortion Legalized abortion and crime effect Libertarian perspectives on abortion Limit of viability Malthusianism Men's rights Minors and abortion Natalism One-child policy Paternal rights and abortion Prenatal development Reproductive rights Self-induced abortion Sex-selective abortion Sidewalk counseling Societal attitudes towards abortion Socialism Toxic abortion Unsafe abortion Women's rights By country Africa Algeria Angola Benin Botswana Burkina Faso Burundi Cameroon Cape Verde Central African Republic Chad Egypt Ghana Kenya Namibia Nigeria South Africa Uganda Zimbabwe Asia Afghanistan Armenia Azerbaijan Bahrain Bangladesh Bhutan Brunei Cambodia China Cyprus East Timor Georgia India Iran Israel Japan Kazakhstan South Korea Malaysia Nepal Northern Cyprus Philippines Qatar Saudi Arabia Singapore Turkey United Arab Emirates Vietnam Yemen Europe Albania Andorra Austria Belarus Belgium Bosnia and Herzegovina Bulgaria Croatia Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland Ireland Italy Kazakhstan Latvia Liechtenstein Lithuania Luxembourg Malta Moldova Monaco Montenegro Netherlands North Macedonia Norway Poland Portugal Romania Russia San Marino Serbia Slovakia Slovenia Spain Sweden Switzerland Ukraine United Kingdom North America Belize Canada Costa Rica Cuba Dominican Republic El Salvador Guatemala Mexico Nicaragua Panama Trinidad and Tobago United States Oceania Australia Micronesia Fiji Kiribati Marshall Islands New Zealand Papua New Guinea Samoa Solomon Islands Tonga Tuvalu Vanuatu South America Argentina Bolivia Brazil Chile Colombia Ecuador Guyana Paraguay Peru Suriname Uruguay Venezuela Law Case law Constitutional law History of abortion law Laws by country Buffer zones Conscientious objection Fetal protection Heartbeat bills Informed consent Late-term restrictions Parental involvement Spousal consent Methods Vacuum aspiration Dilation and evacuation Dilation and curettage Intact D&X Hysterotomy Instillation Menstrual extraction Abortifacient drugs Methotrexate Mifepristone Misoprostol Oxytocin Self-induced abortion Unsafe abortion Religion Buddhism Christianity Catholicism Hinduism Islam Judaism Scientology Category
  • Nutritional Anemia Wikipedia
    Hydrocortisones and valproic acid are also two drugs that cause moderate bleeding from the gut. ... The Free Dictionary. Accessed March 31, 2017. http://medical-dictionary.thefreedictionary.com/nutritionalanemia. ^ a b “What are the symptoms of anemia?” Health Grades, INC. Accessed March 31, 2017. https://www.healthgrades.com/conditions/anemia--symptoms. ^ "Health Library: Symptoms of Nutritional Anemia" . ... Retrieved 27 April 2017 . ^ “Micronutrient deficiencies” World Health Organization. Accessed March 31, 2017. http://www.who.int/nutrition/topics/ida/en/. ^ Kraft, Sy. ... Right Diagnosis. Assessed March 31, 2017. http://www.rightdiagnosis.com/n/nutritional_anemia/treatments.htm External links [ edit ] Classification D ICD - 10 : D50 - D53 ICD - 9-CM : 280 - 281 v t e Diseases of red blood cells ↑ Polycythemia Polycythemia vera ↓ Anemia Nutritional Micro- : Iron-deficiency anemia Plummer–Vinson syndrome Macro- : Megaloblastic anemia Pernicious anemia Hemolytic (mostly normo- ) Hereditary enzymopathy : Glucose-6-phosphate dehydrogenase deficiency glycolysis pyruvate kinase deficiency triosephosphate isomerase deficiency hexokinase deficiency hemoglobinopathy : Thalassemia alpha beta delta Sickle cell disease / trait Hereditary persistence of fetal hemoglobin membrane : Hereditary spherocytosis Minkowski–Chauffard syndrome Hereditary elliptocytosis Southeast Asian ovalocytosis Hereditary stomatocytosis Acquired AIHA Warm antibody autoimmune hemolytic anemia Cold agglutinin disease Donath–Landsteiner hemolytic anemia Paroxysmal cold hemoglobinuria Mixed autoimmune hemolytic anemia membrane paroxysmal nocturnal hemoglobinuria Microangiopathic hemolytic anemia Thrombotic microangiopathy Hemolytic–uremic syndrome Drug-induced autoimmune Drug-induced nonautoimmune Hemolytic disease of the newborn Aplastic (mostly normo- ) Hereditary : Fanconi anemia Diamond–Blackfan anemia Acquired: Pure red cell aplasia Sideroblastic anemia Myelophthisic Blood tests Mean corpuscular volume normocytic microcytic macrocytic Mean corpuscular hemoglobin concentration normochromic hypochromic Other Methemoglobinemia Sulfhemoglobinemia Reticulocytopenia
    EPO, NUCB2, ABCD4, TCN2, HAMP
  • Exudative Vitreoretinopathy 4 Omim
    Mapping In an Asian family with FEVR, Price et al. (1996) found linkage to chromosome 11 (maximum 2-point lod score of 5.55 at D11S533) within the region of the EVR1 locus. ... By high-resolution genotyping of the family reported by Price et al. (1996), Toomes et al. (2004) determined that the disease locus was not EVR1, but rather a distinct locus approximately 10 cM centromeric to the FZD4 gene (604579), which represents EVR1. ... One of the families had been reported by Price et al. (1996). In affected members of the 3 families with autosomal recessive EVR studied by Shastry and Trese (1997) and de Crecchio et al. (1998), Jiao et al. (2004) identified 3 different homozygous mutations in the LRP5 gene: R570Q (603506.0022), R752G (603506.0023), and E1367K (603506.0024).
    LRP5, RCBTB1, ZNF408, CTNNB1, ABCA4, FZD4, TSPAN12, NDP, PRSS23, KIF11, FZD5, FZD1, MAOA, PLXNA2, JAG1, VEGFA, STK39, ILK, OPN1LW
    • Exudative Vitreoretinopathy 5 Omim
      A number sign (#) is used with this entry because familial exudative vitreoretinopathy-5 (EVR5) is caused by heterozygous mutations in the TSPAN12 gene (613138) on chromosome 7q31. Severely affected individuals with homozygous or compound heterozygous mutations in TSPAN12 have also been reported. Description Familial exudative vitreoretinopathy is an inherited blinding disorder caused by defects in the development of retinal vasculature. There is extensive variation in disease severity among patients, even between members of the same family. Severely affected individuals often are registered as blind during infancy and can present with a phenotype resembling retinal dysplasia.
    • Exudative Vitreoretinopathy 1 Omim
      A number sign (#) is used with this entry because familial exudative vitreoretinopathy-1 (EVR1) is caused by heterozygous mutation in the frizzled-4 gene (FZD4; 604579) on chromosome 11q14. A form of retinopathy of prematurity is also caused by mutation in the FZD4 gene. Description Familial exudative vitreoretinopathy (FEVR) is an inherited disorder characterized by the incomplete development of the retinal vasculature. Its clinical appearance varies considerably, even within families, with severely affected patients often registered as blind during infancy, whereas mildly affected patients with few or no visual problems may have such a small area of avascularity in their peripheral retina that it is visible only by fluorescein angiography. It is believed that this peripheral avascularity is the primary anomaly in FEVR and results from defective retinal angiogenesis.
    • Familial Exudative Vitreoretinopathy Orphanet
      Familial exudative vitreoretinopathy (FEVR) is a rare hereditary vitreoretinal disorder characterized by abnormal or incomplete vascularization of the peripheral retina leading to variable clinical manifestations ranging from no effects to minor anomalies, or even retinal detachment with blindness. Epidemiology The prevalence of FEVR is unknown. It is usually inherited dominantly and many asymptomatic individuals may not come to medical attention as a result of non-penetrance. Males and females appear to be affected equally, except in the X-linked form which only affects males. Clinical description The clinical manifestations of FEVR are highly variable among patients in the same family and even between the two eyes. In many patients, retinal abnormalities do not affect vision. Most symptomatic individuals with FEVR present at an early age with peripheral vision disturbances, and flashes or floaters.
    • Exudative Vitreoretinopathy 7 Omim
      A number sign (#) is used with this entry because of evidence that exudative vitreoretinopathy-7 (EVR7) is caused by heterozygous mutation in the CTNNB1 gene (116806) on chromosome 3p22. For a general phenotypic description and a discussion of genetic heterogeneity of exudative vitreoretinopathy, see EVR1 (133780). Clinical Features Panagiotou et al. (2017) studied 2 unrelated families, 1 Japanese (family F410) and 1 Hawaiian of Japanese origin (family F258), segregating autosomal dominant nonsyndromic exudative vitreoretinopathy. In family F410, the proband presented at age 11 with very low vision, and funduscopy showed retinal avascularity, exudation, retinal holes, and bilateral retinal detachment. He had 1 brother who was similarly affected, with retinal avascularity, exudation, and bilateral tractional folds; another brother was clinically unaffected and had a normal fundus examination at age 9 years.
    • Exudative Vitreoretinopathy 6 Omim
      A number sign (#) is used with this entry because of evidence that exudative vitreoretinopathy-6 (EVR6) is caused by heterozygous mutation in the ZNF408 gene (616454) on chromosome 11p11. One such family has been reported. Homozygous mutation in the ZNF408 gene has been reported to cause retinitis pigmentosa (see RP72, 616469). For a general phenotypic description and discussion of genetic heterogeneity of exudative vitreoretinopathy, see EVR1 (133780). Clinical Features Van Nouhuys (1982) described a large 6-generation Dutch pedigree (family D) with exudative vitreoretinopathy (EVR) and provided detailed descriptions of 16 affected individuals. Visual acuity varied widely, with some patients reporting reduced vision from early childhood, whereas others had 20/20 vision on examination.
    • Familial Exudative Vitreoretinopathy Wikipedia
      Familial exudative vitreoretinopathy Other names FEVR (initialism) , Criswick-Schepens syndrome Retina (located at top of diagram) Pronunciation (initialism) / ˈ f iː v ər / Specialty Ophthalmology Prevention treatment = laser surgery Familial exudative vitreoretinopathy ( FEVR , pronounced as fever ) is a genetic disorder affecting the growth and development of blood vessels in the retina of the eye. [1] This disease can lead to visual impairment and sometimes complete blindness in one or both eyes. FEVR is characterized by exudative leakage and hemorrhage of the blood vessels in the retina , along with incomplete vascularization of the peripheral retina. The disease process can lead to retinal folds, tears, and detachments. Treatment Currently laser surgery can be performed in order to prevent further retinal detachment. Future treatment is possible with genetically tailored medications, and ultimately with genetic modifications.
    • Exudative Vitreoretinopathy 2, X-Linked Omim
      A number sign (#) is used with this entry because of evidence that exudative vitreoretinopathy-2 (EVR2) is caused by mutation in the NDP gene (300658), which is also mutant in Norrie disease (310600), on Xp11. Description Familial exudative vitreoretinopathy (FEVR) is an inherited disorder characterized by the incomplete development of the retinal vasculature. Its clinical appearance varies considerably, even within families, with severely affected patients often registered as blind during infancy, whereas mildly affected patients with few or no visual problems may have such a small area of avascularity in their peripheral retina that it is visible only by fluorescein angiography. It is believed that this peripheral avascularity is the primary anomaly in FEVR and results from defective retinal angiogenesis. The sight-threatening features of the FEVR phenotype are considered secondary to retinal avascularity and develop because of the resulting retinal ischemia; they include the development of hyperpermeable blood vessels, neovascularization, vitreoretinal traction, retinal folds, and retinal detachments (summary by Poulter et al., 2010).
    • Exudative Vitreoretinopathy 3 Omim
      Description Familial exudative vitreoretinopathy (FEVR) is an inherited disorder characterized by the incomplete development of the retinal vasculature. Its clinical appearance varies considerably, even within families, with severely affected patients often registered as blind during infancy, whereas mildly affected patients with few or no visual problems may have such a small area of avascularity in their peripheral retina that it is visible only by fluorescein angiography. It is believed that this peripheral avascularity is the primary anomaly in FEVR and results from defective retinal angiogenesis. The sight-threatening features of the FEVR phenotype are considered secondary to retinal avascularity and develop because of the resulting retinal ischemia; they include the development of hyperpermeable blood vessels, neovascularization, vitreoretinal traction, retinal folds, and retinal detachments (summary by Poulter et al., 2010). For a discussion of genetic heterogeneity of familial exudative vitreoretinopathy, see EVR1 (133780).
  • Cardiofaciocutaneous Syndrome 4 Omim
    Two individuals with mutations in this pedigree developed cancer: the proband's maternal great grandmother developed a large B-cell lymphoma at age 70 and the proband's maternal great uncle died of acute lymphoblastic leukemia (ALL) at age 41 years. Linden and Price (2011) reported the second family showing vertical transmission of CFC4. ... His 40-year-old brother and 68-year-old mother had similar features. Linden and Price (2011) emphasized the mild cognitive phenotype in these patients, suggesting greater reproductive success. ... One of the mutation carriers died of acute lymphocytic leukemia (ALL) at age 41 years, which Rauen et al. (2010) postulated may have resulted from increased activity of the RAS pathway. Linden and Price (2011) reported another family with autosomal dominant transmission of CFC associated with a heterozygous mutation in the MEK2 gene (G132D; 601263.0005).
    BRAF, MAP2K1, KRAS, MAP2K2, HRAS, PTPN11, NRAS, RAF1, SOS1, SHOC2, RRAS, A2ML1, MRAS, LZTR1, SOS2, RASA2, RIT1, RASA1, PPP1CB, EPHB2, MAPK1, MAP2K7, SGSM3, ZHX2, YWHAZ, CFC1, NPPC, KANSL1
    • Cardiofaciocutaneous Syndrome 1 Omim
      Most cases occur sporadically, but autosomal dominant transmission has been rarely reported (Linden and Price, 2011). Roberts et al. (2006) provided a detailed review of CFC syndrome, including a discussion of the phenotypic overlap of CFC syndrome with Noonan syndrome (NS1; 163950) and Costello syndrome (218040).
    • Cardiofaciocutaneous Syndrome Wikipedia
      Cardiofaciocutaneous syndrome Cardiofaciocutaneous syndrome is inherited in an autosomal dominant manner [1] Specialty Medical genetics Cardiofaciocutaneous ( CFC ) syndrome is an extremely rare genetic disorder . [2] [3] It is characterized by the following: Distinctive facial appearance Unusually sparse, brittle, curly scalp hair A range of skin abnormalities from dermatitis to thick, scaly skin over the entire body (generalized ichthyosis ) Heart malformations ( congenital or appearing later) especially an obstruction of the normal flow of blood from the lower right ventricle of the heart to the lungs (valvar pulmonary stenosis ) Delayed growth Foot abnormalities (extra toe or fusion of two or more toes) Contents 1 Presentation 2 Genetic 3 Diagnosis 4 Management 5 References 6 External links Presentation [ edit ] Individuals with the disorder usually have distinctive malformations of the craniofacial area including an unusually large head (macrocephaly), prominent forehead, and abnormal narrowing of both sides of the forehead (bitemporal constriction); The nose can be upturned and short with a low nasal bridge; and large ears that are abnormally rotated toward the back of the head. In many cases, affected individuals also have downward slanting eyelid folds, widely spaced eyes, drooping of the upper eyelids, inward deviation of the eyes, and other eye abnormalities including absent eyebrows and eyelashes. [ citation needed ] Genetic [ edit ] Costello and Noonan syndrome are similar to CFC and their phenotypic overlap may be due to the biochemical relationship of the genes mutated in each syndrome to each other. Genes that are mutated in all three of these syndromes encode proteins that function in the MAP kinase pathway. Mutations that cause CFC are found in the KRAS , BRAF , MEK1 and MEK2 genes. Costello syndrome is caused by mutations in HRAS . Mutations that cause Noonan syndrome have been found in PTPN11 and SOS1 .
    • Cardiofaciocutaneous Syndrome Gard
      Cardiofaciocutaneous (CFC) syndrome is a disorder that affects many parts of the body, particularly the heart, face, skin, and hair. People with this condition also have developmental delay and intellectual disability, usually ranging from moderate to severe. The signs and symptoms of CFC syndrome overlap significantly with those of two other conditions, Costello syndrome and Noonan syndrome . These syndromes belong to a group of related conditions called the RASopathies , which are distinguished by their genetic causes and specific pattern of features. It can sometimes be hard to tell these conditions apart in infancy. CFC syndrome is usually caused by a mutation in the BRAF gene, but can also be due to a mutation in the MAP2K1 , MAP2K2 or KRAS g ene.
    • Cardiofaciocutaneous Syndrome Gene_reviews
      Summary Clinical characteristics. Cardiofaciocutaneous (CFC) syndrome is characterized by cardiac abnormalities (pulmonic stenosis and other valve dysplasias, septal defects, hypertrophic cardiomyopathy, rhythm disturbances), distinctive craniofacial appearance, and cutaneous abnormalities (including xerosis, hyperkeratosis, ichthyosis, keratosis pilaris, ulerythema ophryogenes, eczema, pigmented moles, hemangiomas, and palmoplantar hyperkeratosis). The hair is typically sparse, curly, fine or thick, woolly or brittle; eyelashes and eyebrows may be absent or sparse. Nails may be dystrophic or fast growing. Some form of neurologic and/or cognitive delay (ranging from mild to severe) is seen in all affected individuals. Neoplasia, mostly acute lymphoblastic leukemia, has been reported in some individuals. Diagnosis/testing. Diagnosis is based on clinical findings and molecular genetic testing.
    • Cardiofaciocutaneous Syndrome Medlineplus
      Cardiofaciocutaneous syndrome is a disorder that affects many parts of the body, particularly the heart (cardio-), facial features (facio-), and the skin and hair (cutaneous). People with this condition also have delayed development and intellectual disability, usually ranging from moderate to severe. Heart defects occur in most people with cardiofaciocutaneous syndrome. The heart problems most commonly associated with this condition include malformations of one of the heart valves that impairs blood flow from the heart to the lungs (pulmonic stenosis), a hole between the two upper chambers of the heart (atrial septal defect ), and a form of heart disease that enlarges and weakens the heart muscle (hypertrophic cardiomyopathy). Cardiofaciocutaneous syndrome is also characterized by distinctive facial features.
    • Cardiofaciocutaneous Syndrome 3 Omim
      A number sign (#) is used with this entry because of evidence that cardiofaciocutaneous syndrome-3 (CFC3) is caused by heterozygous mutation in the MAP2K1 gene (176872) on chromosome 15q22. For a general phenotypic description and a discussion of genetic heterogeneity of cardiofaciocutaneous syndrome, see CFC1 (115150). Description Cardiofaciocutaneous syndrome (CFC) is a complex developmental disorder involving characteristic craniofacial features, cardiac anomalies, hair and skin abnormalities, postnatal growth deficiency, hypotonia, and developmental delay. Distinctive features of CFC3 include macrostomia and horizontal shape of palpebral fissures (Schulz et al., 2008). Clinical Features Rodriguez-Viciana et al. (2006) reported 2 patients with CFC3.
    • Cardiofaciocutaneous Syndrome 2 Omim
      A number sign (#) is used with this entry because this form of cardiofaciocutaneous syndrome (CFC2) is caused by heterozygous mutation in the KRAS gene (190070) on chromosome 12p12.1. For a general phenotypic description and a discussion of genetic heterogeneity of cardiofaciocutaneous syndrome, see CFC1 (115150). Description Cardiofaciocutaneous (CFC) syndrome is a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects, and mental retardation (summary by Niihori et al., 2006). In a phenotypic comparison of BRAF (164757)-positive and KRAS-positive individuals with CFC, Niihori et al. (2006) observed that patients with KRAS mutations did not have the skin abnormalities, such as ichthyosis, hyperkeratosis, and hemangioma, that were present in patients with BRAF mutation. Clinical Features Wieczorek et al. (1997) described a female patient (patient 2) with cardiofaciocutaneous syndrome.
    • Cardiofaciocutaneous Syndrome Orphanet
      A rare, multiple congenital anomalies syndrome characterized by craniofacial dysmorphology, congenital heart disease, dermatological abnormalities (most commonly hyperkeratotic skin and sparse, curly hair), neurological manifestations (hypotonia, seizures), failure to thrive and intellectual disability. Epidemiology Around 300 cases have been published in the literature to date. Prevalence has been estimated at 1/810,000 people in Japan. However prevalence is believed to be higher. Clinical description Cardiofaciocutaneous (CFC) syndrome displays wide phenotypic variability. Polyhydramnios is often reported. Neonates present at birth with relative macrocephaly, short webbed neck and distinctive dysmorphic craniofacial features (i.e. coarse facial appearance, large forehead, low-set ears, ptosis, downslanting of eyes, epicanthal folds, short nose with depressed nasal bridge, prominent philtrum, high arched palate, thick lower lip).
  • Abortion In Kentucky Wikipedia
    (b) For the stage subsequent to approximately the end of the first trimester, the State, in promoting its interest in the health of the mother, may, if it chooses, regulate the abortion procedure in ways that are reasonably related to maternal health. (c) For the stage subsequent to viability, the State in promoting its interest in the potentiality of human life may, if it chooses, regulate, and even proscribe, abortion except where it is necessary, in appropriate medical judgement, for the preservation of the life or health of the mother. ... Retrieved 2019-05-24 . ^ "TRAP Laws Gain Political Traction While Abortion Clinics—and the Women They Serve—Pay the Price" . Guttmacher Institute . 2013-06-27 . ... Senate Bill 9, known as the “fetal heartbeat bill”, was passed by the Kentucky House on Thursday, March 14, by a vote of 71-19. ^ https://www.aclu.org/cases/emw-womens-surgical-center-v-meier-six-week-ban-and-reason-ban ^ "2019 Regular Session - House Bill 100" . ... Retrieved 2019-05-23 . ^ Jr, Perry Bacon (2019-05-16). "Three Reasons There's A New Push To Limit Abortion In State Legislatures" . ... ISSN 1546-0738 . PMID 31774741 . ^ http://www.crossthebridgeforlife.com/ ^ Bacon, John.
  • Dual Diagnosis Wikipedia
    More often than not psychiatric disorders among drug or alcohol abusers disappear with prolonged abstinence. ... OCLC 899586899 . ^ Austin, Infinite Recovery; USA –206-9063, Austin Drug Rehab. "Sober Living Austin" . Infinite Recovery . ... "Results from the 2011 National Survey on Drug Use and Health: Mental Health Findings" . ... "Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study". ... Addiction . 105 (1): 6–13. doi : 10.1111/j.1360-0443.2009.02673.x . PMID 19712126 . ^ a b http://robertwhitaker.org/robertwhitaker.org/Anatomy%20of%20an%20Epidemic.html ^ "Supersensitivity Psychosis: The Evidence" . 5 November 2010. ^ "Evidence of Neuroleptic Drug-Induced Brain Damage" . 20 January 2000. ^ Steiner W (1990).
  • Abortion In Belarus Wikipedia
    Abortion is allowed on request up to 12 weeks, and in specific circumstances, on a variety of grounds, until 28 weeks. [2] The 1987 law allows abortion for the traditional reasons of harm or death to the fetus and/or mother, rape and incest , as well as: the death of the husband during pregnancy , a jail sentence for either the mother or father, a court order stripping the pregnant woman of parental rights , if a household already exceeds five children, if the relationship between mother and father ends in divorce , or a family history which includes mental or physical disabilities . [1] Once a popular method of birth control , abortions exceeded live births two-to-one in 1995. [3] The rate had fallen by over 75%, with abortions numbering 42,000 (or 39% of the live birth rate) in 2008. [3] As of 2010 [update] , the abortion rate was 14.7 abortions per 1000 women aged 15–44 years. [4] References [ edit ] ^ a b Belarus - ABORTION POLICY - United Nations ^ http://www.womenonwaves.org/en/page/4757/belarus--abortion-law ^ a b Fewer Abortions In Belarus, But More Single Mothers ^ "World Abortion Policies 2013" . ... Retrieved 3 March 2014 . v t e Abortion in Europe Sovereign states Albania Andorra Armenia Austria Azerbaijan Belarus Belgium Bosnia and Herzegovina Bulgaria Croatia Cyprus Czech Republic Denmark Estonia Finland France Georgia Germany Greece Hungary Iceland Ireland Italy Kazakhstan Latvia Liechtenstein Lithuania Luxembourg Malta Moldova Monaco Montenegro Netherlands North Macedonia Norway Poland Portugal Romania Russia San Marino Serbia Slovakia Slovenia Spain Sweden Switzerland Turkey Ukraine United Kingdom England Northern Ireland Scotland Wales Vatican City States with limited recognition Abkhazia Artsakh Kosovo Northern Cyprus South Ossetia Transnistria v t e Abortion Main topics Definitions History Methods Abortion debate Philosophical aspects Abortion law Movements Abortion-rights movements Anti-abortion movements Issues Abortion and mental health Beginning of human personhood Beginning of pregnancy controversy Abortion-breast cancer hypothesis Anti-abortion violence Abortion under communism Birth control Crisis pregnancy center Ethical aspects of abortion Eugenics Fetal rights Forced abortion Genetics and abortion Late-term abortion Legalized abortion and crime effect Libertarian perspectives on abortion Limit of viability Malthusianism Men's rights Minors and abortion Natalism One-child policy Paternal rights and abortion Prenatal development Reproductive rights Self-induced abortion Sex-selective abortion Sidewalk counseling Societal attitudes towards abortion Socialism Toxic abortion Unsafe abortion Women's rights By country Africa Algeria Angola Benin Botswana Burkina Faso Burundi Cameroon Cape Verde Central African Republic Chad Egypt Ghana Kenya Namibia Nigeria South Africa Uganda Zimbabwe Asia Afghanistan Armenia Azerbaijan Bahrain Bangladesh Bhutan Brunei Cambodia China Cyprus East Timor Georgia India Iran Israel Japan Kazakhstan South Korea Malaysia Nepal Northern Cyprus Philippines Qatar Saudi Arabia Singapore Turkey United Arab Emirates Vietnam Yemen Europe Albania Andorra Austria Belarus Belgium Bosnia and Herzegovina Bulgaria Croatia Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland Ireland Italy Kazakhstan Latvia Liechtenstein Lithuania Luxembourg Malta Moldova Monaco Montenegro Netherlands North Macedonia Norway Poland Portugal Romania Russia San Marino Serbia Slovakia Slovenia Spain Sweden Switzerland Ukraine United Kingdom North America Belize Canada Costa Rica Cuba Dominican Republic El Salvador Guatemala Mexico Nicaragua Panama Trinidad and Tobago United States Oceania Australia Micronesia Fiji Kiribati Marshall Islands New Zealand Papua New Guinea Samoa Solomon Islands Tonga Tuvalu Vanuatu South America Argentina Bolivia Brazil Chile Colombia Ecuador Guyana Paraguay Peru Suriname Uruguay Venezuela Law Case law Constitutional law History of abortion law Laws by country Buffer zones Conscientious objection Fetal protection Heartbeat bills Informed consent Late-term restrictions Parental involvement Spousal consent Methods Vacuum aspiration Dilation and evacuation Dilation and curettage Intact D&X Hysterotomy Instillation Menstrual extraction Abortifacient drugs Methotrexate Mifepristone Misoprostol Oxytocin Self-induced abortion Unsafe abortion Religion Buddhism Christianity Catholicism Hinduism Islam Judaism Scientology Category This abortion -related article is a stub .
  • Abortion In Bosnia And Herzegovina Wikipedia
    Between ten and twenty weeks, an abortion must be approved by a committee, and is permitted when the woman's life or health is threatened, when the fetus is severely impaired, when the pregnancy results from a crime, and for psychosocial reasons. In all cases, women must undergo counseling first. [1] After 20 weeks, abortion is only permitted to save the woman's life or health. ... United Nations. 2013 . Retrieved 3 March 2014 . ^ http://assets.pewresearch.org/wp-content/uploads/sites/11/2017/05/09154356/Central-and-Eastern-Europe-Topline_FINAL-FOR-PUBLICATION.pdf v t e Abortion in Europe Sovereign states Albania Andorra Armenia Austria Azerbaijan Belarus Belgium Bosnia and Herzegovina Bulgaria Croatia Cyprus Czech Republic Denmark Estonia Finland France Georgia Germany Greece Hungary Iceland Ireland Italy Kazakhstan Latvia Liechtenstein Lithuania Luxembourg Malta Moldova Monaco Montenegro Netherlands North Macedonia Norway Poland Portugal Romania Russia San Marino Serbia Slovakia Slovenia Spain Sweden Switzerland Turkey Ukraine United Kingdom England Northern Ireland Scotland Wales Vatican City States with limited recognition Abkhazia Artsakh Kosovo Northern Cyprus South Ossetia Transnistria v t e Abortion Main topics Definitions History Methods Abortion debate Philosophical aspects Abortion law Movements Abortion-rights movements Anti-abortion movements Issues Abortion and mental health Beginning of human personhood Beginning of pregnancy controversy Abortion-breast cancer hypothesis Anti-abortion violence Abortion under communism Birth control Crisis pregnancy center Ethical aspects of abortion Eugenics Fetal rights Forced abortion Genetics and abortion Late-term abortion Legalized abortion and crime effect Libertarian perspectives on abortion Limit of viability Malthusianism Men's rights Minors and abortion Natalism One-child policy Paternal rights and abortion Prenatal development Reproductive rights Self-induced abortion Sex-selective abortion Sidewalk counseling Societal attitudes towards abortion Socialism Toxic abortion Unsafe abortion Women's rights By country Africa Algeria Angola Benin Botswana Burkina Faso Burundi Cameroon Cape Verde Central African Republic Chad Egypt Ghana Kenya Namibia Nigeria South Africa Uganda Zimbabwe Asia Afghanistan Armenia Azerbaijan Bahrain Bangladesh Bhutan Brunei Cambodia China Cyprus East Timor Georgia India Iran Israel Japan Kazakhstan South Korea Malaysia Nepal Northern Cyprus Philippines Qatar Saudi Arabia Singapore Turkey United Arab Emirates Vietnam Yemen Europe Albania Andorra Austria Belarus Belgium Bosnia and Herzegovina Bulgaria Croatia Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland Ireland Italy Kazakhstan Latvia Liechtenstein Lithuania Luxembourg Malta Moldova Monaco Montenegro Netherlands North Macedonia Norway Poland Portugal Romania Russia San Marino Serbia Slovakia Slovenia Spain Sweden Switzerland Ukraine United Kingdom North America Belize Canada Costa Rica Cuba Dominican Republic El Salvador Guatemala Mexico Nicaragua Panama Trinidad and Tobago United States Oceania Australia Micronesia Fiji Kiribati Marshall Islands New Zealand Papua New Guinea Samoa Solomon Islands Tonga Tuvalu Vanuatu South America Argentina Bolivia Brazil Chile Colombia Ecuador Guyana Paraguay Peru Suriname Uruguay Venezuela Law Case law Constitutional law History of abortion law Laws by country Buffer zones Conscientious objection Fetal protection Heartbeat bills Informed consent Late-term restrictions Parental involvement Spousal consent Methods Vacuum aspiration Dilation and evacuation Dilation and curettage Intact D&X Hysterotomy Instillation Menstrual extraction Abortifacient drugs Methotrexate Mifepristone Misoprostol Oxytocin Self-induced abortion Unsafe abortion Religion Buddhism Christianity Catholicism Hinduism Islam Judaism Scientology Category This abortion -related article is a stub .
  • Bochdalek Hernia Wikipedia
    Children's Hospital of Wisconsin, Wisconsin. 3 Feb. 2007 < http://www.chw.org/display/PPF/DocID/22791/router.asp > ^ a b Jeffrey, Mark E., and Wilbur A. ... HealthSystems. 24 Nov. 2006. UVA Health. 3 Feb. 2007. < http://www.healthsystem.virginia.edu/UVAHealth/peds_digest/diaphrag.cfm >. ^ Larrazábal, Natasha. ... Diaphragmatic hernia. 6 Feb. 2007 < http://www.thefetus.net/page.php?id=1218 > Archived July 27, 2009, at the Wayback Machine . ^ a b Hekmatnia, Ali, and Kieran McHugh. "Congenital Diaphragmatic Hernia." EMedicine (2003). 8 Feb. 2007 < http://www.emedicine.com/RADIO/topic187.htm >. ^ Klein, Jaquier M. ... J Formos Med Assoc. 2001;100(3):173-175. ^ http://www.perinatology.com/calculators/LHRnrew.htm ^ https://eapsa.org/apsa/media/Documents/APSA-CDH-Brochure_Updated-Jul2018_FNL.pdf ^ https://fetus.ucsf.edu/cdh#a2 ^ http://www.perinatology.com/calculators/LHRnrew.htm ^ https://eapsa.org/apsa/media/Documents/APSA-CDH-Brochure_Updated-Jul2018_FNL.pdf ^ https://eapsa.org/apsa/media/Documents/APSA-CDH-Brochure_Updated-Jul2018_FNL.pdf ^ https://www.texaschildrens.org/sites/default/files/uploads/documents/outcomes/standards/CDH_Dec2017.pdf ^ https://www.texaschildrens.org/sites/default/files/uploads/documents/outcomes/standards/CDH_Dec2017.pdf External links [ edit ] Classification D ICD - 10 : Q79.0 ICD - 9-CM : 756.6 DiseasesDB : 31492 v t e Congenital diaphragm and abdominal wall defects, abdominopelvic cavity Thoracic diaphragm Hernia Congenital diaphragmatic hernia Bochdalek hernia Abdominal wall Omphalocele Gastroschisis Prune belly syndrome
    RHOA, CCN2, KCNQ5, FGFRL1, WT1, WNT11, STAT3, CCL2, PIM1, MYOD1, INSR, IGF2R, IGF1R, GATA4, FOXC2, FOXF1, EPO, DES, FREM1, RPS19, DISP1
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