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  • Mullerian Anomalies Wikipedia
    The most prevalent form of vaginal agenesis is Mayer–Rokitansky–Kuster–Hauser (MRKH) syndrome and results in congenital aplasia or hypoplasia of mullerian derived structures. [7] MRKH syndrome account for 5% to 10% of all mullerian anomalies. ... "Genetics of Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome". Clinical Genetics . 91 (2): 233–246. doi : 10.1111/cge.12883 . ... "Genetic analysis of Mayer–Rokitansky–Kuster–Hauser syndrome in a large cohort of families" . ... "Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome with septic shock: A case report". ... "Mayer–Rokitansky–Kuster–Hauser syndrome: recent clinical and genetic findings".
  • Alien Hand Syndrome Wikipedia
    Statements consisting only of original research should be removed. ( October 2015 ) ( Learn how and when to remove this template message ) Alien hand syndrome Other names AHS; alien limb syndrome; ALS; Dr. Strangelove syndrome Specialty Psychiatry , Neurology Alien hand syndrome ( AHS ) or Dr. ... "Dr. Strangelove syndrome" was suggested as the official name for AHS. ... "The alien hand syndrome" . Proceedings (Baylor University. ... "Alien hand syndrome of the dominant hand and ideomotor apraxia of the nondominant hand".
  • Gallbladder Neuroendocrine Tumor Orphanet
    Patients may be asymptomatic (diagnosed incidentally after surgical resection of the gallbladder) or may present epigastric pain, abdominal mass and/or non-specific symptoms, such as nausea, jaundice, flushing, cough, wheezing, ascites, and anepithymia. Paraneoplastic syndromes, such as Cushing syndrome, hypercalcemia, acanthosis nigricans, bullous pemphigoid, dermatomyositis and the Leser-Trélat sign, may be associated.
  • Coloboma Of Eyelid Orphanet
    It may occur isolated, be associated with other ocular defects or be part of a craniofacial syndrome, such as Treacher-Collins or Goldenhar syndrome.
    PAX6, SALL2, FZD5, ABCB6, FREM1, ADAR, ADNP, ESCO2, CCNQ, RNASEH2C, RNASEH2B, IFIH1, CHD7, RIPK4, POLR1D, SAMHD1, RNASEH2A, TREX1, CDH11, SEMA3E, POLR1C, ALX1, TCOF1, KRAS, FLI1, FGFR1, DHODH, KCTD1
  • Infantile Nephropathic Cystinosis Orphanet
    A subtype of cystinosis characterized by an accumulation of cystine in the organs and tissues, particularly in the kidneys and eyes, and that clinically manifests from infancy with renal Fanconi syndrome, photophobia, hypothyroidism, impaired growth and rickets, in addition to various other systemic effects. Progressive extra-renal manifestations include hypothyroidism, hypogonadism and male infertility, insulin-dependent diabetes, hepatosplenomegaly with portal hypertension, muscle involvement with distal muscle weakness and atrophy, pharyngeal and oral dysfunction, swallowing difficulties, cerebral involvement with hypotonia, speech and walking difficulties, and cerebellar syndrome.
    CTNS
    • Cystinosis, Nephropathic Omim
      The features resulting from accumulation of cystine in the kidney are those of the Fanconi syndrome (134600). Teree et al. (1970) studied physiologically and anatomically 2 male sibs with cystinosis. ... Reiss et al. (1988) described successful pregnancy in a 20-year-old woman in whom the diagnosis of cystinosis had been made at the age of 6 on the basis of corneal crystals and renal tubular Fanconi syndrome. At the age of 8 years, renal failure required dialysis, and 1 year later she underwent renal allograft from her father. ... In a comprehensive review of cystinosis, Gahl et al. (2002) tabulated the age-related clinical characteristics of untreated nephropathic cystinosis, giving age of onset and prevalence in affected patients: renal Fanconi syndrome, 6 to 12 months, 95%; hypothyroidism, 5 to 10 years, 50%; photophobia, 8 to 12 years, 50%; chronic renal failure, 8 to 12 years, 95%; myopathy, difficulty swallowing, 12 to 40 years, 20%; retinal blindness, 13 to 40 years, 10-15%; diabetes mellitus, 18 to 40 years, 5%; male hypogonadism, 18 to 40 years, 70%; pulmonary dysfunction, 21 to 40 years, 100%; CNS calcifications, 21 to 40 years, 15%; and CNS symptomatic deterioration, 21 to 40 years, 2%. ... In a patient who had atypical nephropathic cystinosis, presenting with Fanconi syndrome (134600) and end-stage renal disease, but surprisingly without extrarenal symptoms even late in life, Kalatzis et al. (2002) detected a missense mutation in the CTNS gene (G110V; 606272.0017). INHERITANCE - Autosomal recessive GROWTH Height - Normal birth length - Short stature in first year of life Weight - Normal birth weight Other - Failure to thrive in first year of life HEAD & NECK Face - Frontal bossing Eyes - Photophobia - Peripheral retinopathy - Decreased visual acuity - Corneal crystals - Recurrent corneal erosions CHEST Ribs Sternum Clavicles & Scapulae - Rachitic rosary ABDOMEN Liver - Hepatomegaly Pancreas - Pancreatic insufficiency Spleen - Splenomegaly GENITOURINARY Kidneys - Renal tubular Fanconi syndrome - Renal failure - Renal calculi (urate and calcium oxalate) SKELETAL - Hypophosphatemic rickets - Delayed bone age Limbs - Metaphyseal widening - Genu valgum SKIN, NAILS, & HAIR Skin - Decreased ability to sweat - Light skin pigmentation compared to unaffected sibs Hair - Light hair pigmentation compared to unaffected sibs MUSCLE, SOFT TISSUES - Muscle wasting - Myopathy - Swallowing difficulties NEUROLOGIC Central Nervous System - Normal intelligence - Cerebral atrophy - Neurologic deterioration in long-term survivors - Specific visual spatial processing defect VOICE - Hypophonic speech METABOLIC FEATURES - Recurrent episodes of acidosis - Recurrent episodes of dehydration - Polyuria - Polydipsia ENDOCRINE FEATURES - Primary hypothyroidism - Insulin dependent diabetes mellitus - Delayed puberty LABORATORY ABNORMALITIES - Proteinuria - Glucosuria - Normal blood glucose - Hyponatremia - Kypokalemia - Carnitine deficiency - Hypophosphatemia - Generalized aminoaciduria - Microscopic hematuria - Elevated white blood cell cystine MISCELLANEOUS - Male infertility - Incidence 1/100,000 - 1/200,000 live births - Presentation in first year of life - Three types of cystinosis are recognized - (1) infantile nephropathic ( 219800 ), (2) juvenile or adolescent nephropathic ( 219900 ), (3) adult nonnephropathic ( 219750 ) MOLECULAR BASIS - Caused by mutation in the cystinosin gene (CTNS, 219800.0001 ) ▲ Close
  • Neuropathy With Hearing Impairment Orphanet
    This syndrome is characterized by the association of sensorineural hearing impairment and peripheral neuropathy. ... Etiology Neuropathy with hearing impairment is caused by mutations in the GJB3 gene (1p34). Genetic counseling The syndrome is transmitted in an autosomal dominant manner.
    GJB3
  • Sixth Nerve Palsy Wikipedia
    Petrous apex [ edit ] The nerve passes adjacent to the mastoid sinus and is vulnerable to mastoiditis , leading to inflammation of the meninges, which can give rise to Gradenigo's syndrome . This condition results in a VIth nerve palsy with an associated reduction in hearing ipsilaterally, plus facial pain and paralysis, and photophobia. ... Possible alternative diagnosis for an abduction deficit would include: 1. Mobius syndrome - a rare congenital disorder in which both VIth and VIIth nerves are bilaterally affected giving rise to a typically 'expressionless' face. 2. Duane syndrome - A condition in which both abduction and adduction are affected arising as a result of partial innervation of the lateral rectus by branches from the IIIrd oculomotor cranial nerve. 3. Cross fixation which develops in the presence of infantile esotropia or nystagmus blockage syndrome and results in habitual weakness of lateral recti. 4. ... Paris. 3 : 749–754, 789–792, 811–816. ; English translation in Wolf JK, ed. (1971). The Classical Brain Stem Syndromes (translations of the original papers with notes on the evolution of clinical Neuroanatomy) .
    • Sixth Nerve Palsy Gard
      Sixth nerve palsy is a nerve disorder that occurs when the sixth cranial nerve is damaged. The disorder prevents some of the muscles that control eye movement from working properly. Affected people cannot turn the eye outwards toward the ear. Other signs and symptoms may include double vision, headaches, and pain around the eye. Sixth nerve palsy may be caused by many things, including stroke, brain aneurysm , diabetic neuropathy , trauma, infections, inflammation, tumors, migraine headaches or intracranial pressure . Eye patches, glasses, corticosteroids, and/or botulinum toxin may be used to ease symptoms.
  • Onychotrichodysplasia And Neutropenia Omim
    Clinical Features Cantu et al. (1975) described a male infant, born of consanguineous parents, with a previously undescribed syndrome consisting of hypoplastic fingernails, trichorrhexis, chronic neutropenia, and psychomotor retardation. In 2 daughters, and perhaps a third, of first-cousin parents, Hernandez et al. (1979) observed the same syndrome. IQ was in the vicinity of 70. ... Verhage et al. (1987) concluded that the chronic neutropenia falls into the category of 'lazy leukocyte syndrome' (150550), a heterogeneous entity.
  • Normochromic Anemia Wikipedia
    Elsevier. 2018. pp. 477–506. v t e Diseases of red blood cells ↑ Polycythemia Polycythemia vera ↓ Anemia Nutritional Micro- : Iron-deficiency anemia Plummer–Vinson syndrome Macro- : Megaloblastic anemia Pernicious anemia Hemolytic (mostly normo- ) Hereditary enzymopathy : Glucose-6-phosphate dehydrogenase deficiency glycolysis pyruvate kinase deficiency triosephosphate isomerase deficiency hexokinase deficiency hemoglobinopathy : Thalassemia alpha beta delta Sickle cell disease / trait Hereditary persistence of fetal hemoglobin membrane : Hereditary spherocytosis Minkowski–Chauffard syndrome Hereditary elliptocytosis Southeast Asian ovalocytosis Hereditary stomatocytosis Acquired AIHA Warm antibody autoimmune hemolytic anemia Cold agglutinin disease Donath–Landsteiner hemolytic anemia Paroxysmal cold hemoglobinuria Mixed autoimmune hemolytic anemia membrane paroxysmal nocturnal hemoglobinuria Microangiopathic hemolytic anemia Thrombotic microangiopathy Hemolytic–uremic syndrome Drug-induced autoimmune Drug-induced nonautoimmune Hemolytic disease of the newborn Aplastic (mostly normo- ) Hereditary : Fanconi anemia Diamond–Blackfan anemia Acquired: Pure red cell aplasia Sideroblastic anemia Myelophthisic Blood tests Mean corpuscular volume normocytic microcytic macrocytic Mean corpuscular hemoglobin concentration normochromic hypochromic Other Methemoglobinemia Sulfhemoglobinemia Reticulocytopenia This article about a disease of the blood or immune system is a stub .
    ALDOA, BPGM, HK1, LCAT, RPL15, TPI1, SF3B1, TET2, EPO
  • Refractory Anemia With Ring Sideroblasts Wikipedia
    Refractory anemia with ring sideroblasts Other names RARS Refractory anemia with ring sideroblasts is a type of myelodysplastic syndrome . RARS is characterized by 5% or less myeloblasts in bone marrow. ... External links [ edit ] Classification D ICD-O : M9982/3 v t e Myeloid -related hematological malignancy CFU-GM / and other granulocytes CFU-GM Myelocyte AML : Acute myeloblastic leukemia M0 M1 M2 APL/M3 MP Chronic neutrophilic leukemia Monocyte AML AMoL/M5 Myeloid dendritic cell leukemia CML Philadelphia chromosome Accelerated phase chronic myelogenous leukemia Myelomonocyte AML M4 MD-MP Juvenile myelomonocytic leukemia Chronic myelomonocytic leukemia Other Histiocytosis CFU-Baso AML Acute basophilic CFU-Eos AML Acute eosinophilic MP Chronic eosinophilic leukemia / Hypereosinophilic syndrome MEP CFU-Meg MP Essential thrombocytosis Acute megakaryoblastic leukemia CFU-E AML Erythroleukemia/M6 MP Polycythemia vera MD Refractory anemia Refractory anemia with excess of blasts Chromosome 5q deletion syndrome Sideroblastic anemia Paroxysmal nocturnal hemoglobinuria Refractory cytopenia with multilineage dysplasia CFU-Mast Mastocytoma Mast cell leukemia Mast cell sarcoma Systemic mastocytosis Mastocytosis : Diffuse cutaneous mastocytosis Erythrodermic mastocytosis Adult type of generalized eruption of cutaneous mastocytosis Urticaria pigmentosa Mast cell sarcoma Solitary mastocytoma Systemic mastocytosis Xanthelasmoidal mastocytosis Multiple/unknown AML Acute panmyelosis with myelofibrosis Myeloid sarcoma MP Myelofibrosis Acute biphenotypic leukaemia This oncology article is a stub .
    SF3B1, TET2, HSPA9, ERBB3, JAK2, RARS1, ABCB7, FTMT, YWHAE, PAFAH1B1, MPL, ASXL1, ALAS2, CD34, FANCB, HLA-DRB1, CDK13, SLC25A38, AR, SLC25A37, FOXP3, IGHV1-12, BCR, SLU7, GDF15, CXCR4, VEGFA, TWIST1, TP53, CSF3, ALAD, POU2AF1, DNMT3A, NRAS, EPOR, RAP1GAP
    • Acquired Idiopathic Sideroblastic Anemia Orphanet
      A rare myelodysplastic syndrome (MDS) characterized by ineffective hemopoiesis affecting one or more blood cell lineages (myeloid, erythroid or megakaryocytic) leading to peripheral blood cytopenias and an increased risk of developing leukaemia.
    • Sideroblastic Anemia Pyridoxine-Refractory Autosomal Recessive Gard
      Sideroblastic anemia pyridoxine-refractory autosomal recessive is an inherited blood disorder that is characterized by an impaired ability of the bone marrow to produce normal red blood cells. The iron inside red blood cells is inadequately used to make hemoglobin , despite adequate or increased amounts of iron. Abnormal red blood cells called sideroblasts are found in the blood of people with this anemia. It is caused by mutations in the SLC25A38 gene. It is inherited in an autosomal recessive fashion. Unlike other forms of sideroblastic anemia, this form is not responsive to vitamin B6 (pyridoxine).
  • Uterine Hyperplasia Wikipedia
    It can be a symptom of medical conditions such as adenomyosis , uterine fibroids , ovarian cysts , and endometrial cancer . [1] See also [ edit ] Uterine hypoplasia References [ edit ] ^ "Enlarged Uterus Causes" . v t e Female diseases of the pelvis and genitals Internal Adnexa Ovary Endometriosis of ovary Female infertility Anovulation Poor ovarian reserve Mittelschmerz Oophoritis Ovarian apoplexy Ovarian cyst Corpus luteum cyst Follicular cyst of ovary Theca lutein cyst Ovarian hyperstimulation syndrome Ovarian torsion Fallopian tube Female infertility Fallopian tube obstruction Hematosalpinx Hydrosalpinx Salpingitis Uterus Endometrium Asherman's syndrome Dysfunctional uterine bleeding Endometrial hyperplasia Endometrial polyp Endometriosis Endometritis Menstruation Flow Amenorrhoea Hypomenorrhea Oligomenorrhea Pain Dysmenorrhea PMS Timing Menometrorrhagia Menorrhagia Metrorrhagia Female infertility Recurrent miscarriage Myometrium Adenomyosis Parametrium Parametritis Cervix Cervical dysplasia Cervical incompetence Cervical polyp Cervicitis Female infertility Cervical stenosis Nabothian cyst General Hematometra / Pyometra Retroverted uterus Vagina Hematocolpos / Hydrocolpos Leukorrhea / Vaginal discharge Vaginitis Atrophic vaginitis Bacterial vaginosis Candidal vulvovaginitis Hydrocolpos Sexual dysfunction Dyspareunia Hypoactive sexual desire disorder Sexual arousal disorder Vaginismus Urogenital fistulas Ureterovaginal Vesicovaginal Obstetric fistula Rectovaginal fistula Prolapse Cystocele Enterocele Rectocele Sigmoidocele Urethrocele Vaginal bleeding Postcoital bleeding Other / general Pelvic congestion syndrome Pelvic inflammatory disease External Vulva Bartholin's cyst Kraurosis vulvae Vestibular papillomatosis Vulvitis Vulvodynia Clitoral hood or clitoris Persistent genital arousal disorder This medical symptom article is a stub .
  • Dilated Pore Wikipedia
    Our Dermatology Online . 3 (Suppl.1): 409–413. doi : 10.7241/ourd.20133.103 . v t e Cancers of skin and associated structures Glands Sweat gland Eccrine Papillary eccrine adenoma Eccrine carcinoma Eccrine nevus Syringofibroadenoma Spiradenoma Apocrine Cylindroma Dermal cylindroma Syringocystadenoma papilliferum Papillary hidradenoma Hidrocystoma Apocrine gland carcinoma Apocrine nevus Eccrine / apocrine Syringoma Hidradenoma or Acrospiroma / Hidradenocarcinoma Ceruminous adenoma Sebaceous gland Nevus sebaceous Muir–Torre syndrome Sebaceous carcinoma Sebaceous adenoma Sebaceoma Sebaceous nevus syndrome Sebaceous hyperplasia Mantleoma Hair Pilomatricoma / Malignant pilomatricoma Trichoepithelioma Multiple familial trichoepithelioma Solitary trichoepithelioma Desmoplastic trichoepithelioma Generalized trichoepithelioma Trichodiscoma Trichoblastoma Fibrofolliculoma Trichilemmoma Trichilemmal carcinoma Proliferating trichilemmal cyst Giant solitary trichoepithelioma Trichoadenoma Trichofolliculoma Dilated pore Isthmicoma Fibrofolliculoma Perifollicular fibroma Birt–Hogg–Dubé syndrome Hamartoma Basaloid follicular hamartoma Folliculosebaceous cystic hamartoma Folliculosebaceous-apocrine hamartoma Nails Neoplasms of the nailbed This Epidermal nevi, neoplasms, cysts article is a stub .
  • Malignant Acrospiroma Wikipedia
    External links [ edit ] Classification D ICD-O : 8402/3 MeSH : D018250 v t e Cancers of skin and associated structures Glands Sweat gland Eccrine Papillary eccrine adenoma Eccrine carcinoma Eccrine nevus Syringofibroadenoma Spiradenoma Apocrine Cylindroma Dermal cylindroma Syringocystadenoma papilliferum Papillary hidradenoma Hidrocystoma Apocrine gland carcinoma Apocrine nevus Eccrine / apocrine Syringoma Hidradenoma or Acrospiroma / Hidradenocarcinoma Ceruminous adenoma Sebaceous gland Nevus sebaceous Muir–Torre syndrome Sebaceous carcinoma Sebaceous adenoma Sebaceoma Sebaceous nevus syndrome Sebaceous hyperplasia Mantleoma Hair Pilomatricoma / Malignant pilomatricoma Trichoepithelioma Multiple familial trichoepithelioma Solitary trichoepithelioma Desmoplastic trichoepithelioma Generalized trichoepithelioma Trichodiscoma Trichoblastoma Fibrofolliculoma Trichilemmoma Trichilemmal carcinoma Proliferating trichilemmal cyst Giant solitary trichoepithelioma Trichoadenoma Trichofolliculoma Dilated pore Isthmicoma Fibrofolliculoma Perifollicular fibroma Birt–Hogg–Dubé syndrome Hamartoma Basaloid follicular hamartoma Folliculosebaceous cystic hamartoma Folliculosebaceous-apocrine hamartoma Nails Neoplasms of the nailbed This Epidermal nevi, neoplasms, cysts article is a stub .
    ESR1
  • Malignant Pilomatricoma Wikipedia
    External links [ edit ] Classification D ICD - 10 : C44 ( ILDS C44.L45) v t e Cancers of skin and associated structures Glands Sweat gland Eccrine Papillary eccrine adenoma Eccrine carcinoma Eccrine nevus Syringofibroadenoma Spiradenoma Apocrine Cylindroma Dermal cylindroma Syringocystadenoma papilliferum Papillary hidradenoma Hidrocystoma Apocrine gland carcinoma Apocrine nevus Eccrine / apocrine Syringoma Hidradenoma or Acrospiroma / Hidradenocarcinoma Ceruminous adenoma Sebaceous gland Nevus sebaceous Muir–Torre syndrome Sebaceous carcinoma Sebaceous adenoma Sebaceoma Sebaceous nevus syndrome Sebaceous hyperplasia Mantleoma Hair Pilomatricoma / Malignant pilomatricoma Trichoepithelioma Multiple familial trichoepithelioma Solitary trichoepithelioma Desmoplastic trichoepithelioma Generalized trichoepithelioma Trichodiscoma Trichoblastoma Fibrofolliculoma Trichilemmoma Trichilemmal carcinoma Proliferating trichilemmal cyst Giant solitary trichoepithelioma Trichoadenoma Trichofolliculoma Dilated pore Isthmicoma Fibrofolliculoma Perifollicular fibroma Birt–Hogg–Dubé syndrome Hamartoma Basaloid follicular hamartoma Folliculosebaceous cystic hamartoma Folliculosebaceous-apocrine hamartoma Nails Neoplasms of the nailbed
    SMUG1, LEF1
    • Pilomatrix Carcinoma Orphanet
      A rare skin tumor characterized by an asymptomatic, solitary, often ulcerated nodule most commonly located in the face, involving the deep dermis, subcutaneous tissue, and skeletal muscle and fascia. Histopathologically, the lesion is composed of aggregates of atypical basaloid cells with numerous mitoses. Typical features include shadow cells, keratin cysts, and trichohyalin and keratohyalin granules. The tumor is locally aggressive and shows a tendency to recur after incomplete excision. Regional lymph node or visceral metastasis has been reported.
  • Kniest-Like Dysplasia, Lethal Omim
    Clinical Features Sconyers et al. (1983) described male and female offspring of nonconsanguineous parents who died in the neonatal period with a severe skeletal dysplasia that radiologically and histologically resembled Kniest syndrome but differed in clinical course and inheritance. Kniest syndrome (156550) is usually not lethal in the neonatal period and is inherited as an autosomal dominant. ... Reference was made to another autosomal recessive Kniest-like dysplasia, the Rolland-Desbuquois syndrome (see 224400). For discussion of another Kniest-like dysplasia, see 245160.
    • Lethal Kniest-Like Dysplasia Orphanet
      A rare, lethal, congenital, chondrodysplasia disorder characterized by dumbbell-shaped long bones with markedly shortened diaphyses and metaphyseal irregularities associated with a 'Swiss cheese' appearance of the cartilage matrix, as well as distinctive changes in the growth plate and resting cartilage, resulting in death in the neonatal period. There have been no further descriptions in the literature since 1983.
  • Neoplasms Of The Nailbed Wikipedia
    You can help Wikipedia by expanding it . v t e v t e Cancers of skin and associated structures Glands Sweat gland Eccrine Papillary eccrine adenoma Eccrine carcinoma Eccrine nevus Syringofibroadenoma Spiradenoma Apocrine Cylindroma Dermal cylindroma Syringocystadenoma papilliferum Papillary hidradenoma Hidrocystoma Apocrine gland carcinoma Apocrine nevus Eccrine / apocrine Syringoma Hidradenoma or Acrospiroma / Hidradenocarcinoma Ceruminous adenoma Sebaceous gland Nevus sebaceous Muir–Torre syndrome Sebaceous carcinoma Sebaceous adenoma Sebaceoma Sebaceous nevus syndrome Sebaceous hyperplasia Mantleoma Hair Pilomatricoma / Malignant pilomatricoma Trichoepithelioma Multiple familial trichoepithelioma Solitary trichoepithelioma Desmoplastic trichoepithelioma Generalized trichoepithelioma Trichodiscoma Trichoblastoma Fibrofolliculoma Trichilemmoma Trichilemmal carcinoma Proliferating trichilemmal cyst Giant solitary trichoepithelioma Trichoadenoma Trichofolliculoma Dilated pore Isthmicoma Fibrofolliculoma Perifollicular fibroma Birt–Hogg–Dubé syndrome Hamartoma Basaloid follicular hamartoma Folliculosebaceous cystic hamartoma Folliculosebaceous-apocrine hamartoma Nails Neoplasms of the nailbed
  • Faciocardiomelic Syndrome Omim
    Clinical Features Garcia-Ortiz et al. (2007) reported a sister and 2 brothers who had neonatal macrosomia, mental retardation, microcephaly, distinctive facial features, large neck, narrow shoulders, prominent trapezoid muscles, polydactyly type A in all extremities, and congenital heart disease consisting of single atrium. Their facial features involved flat nasal bridge, exotropia, palpebral ptosis, short eyelashes, telecanthus, anteverted nostrils, broad nasal fossae, long philtrum, macrostomia, prominent maxilla, dental malocclusion, and micrognathia. Radiologic findings included cuboid-shaped vertebral bodies, hypoplastic pelvis, slender long bones with thin cortices, molding disturbance of metacarpal bones, proximal megaepiphyses of metatarsal bones, hypertrophy of first ray, osteopenia, and delayed and dysharmonic bone age. The unaffected parents were not known to be consanguineous but were born in small villages from the same geographic area. Four other sibs, 1 sister and 3 brothers, were reported to be healthy, without polydactyly or heart defects, and did not resemble the affected sibs facially.
  • Congenital Hypoplastic Anemia Wikipedia
    Associated genes include TERC , TERT , IFNG , NBS1 , PRF1 , and SBDS . [1] Examples include: Fanconi anemia Diamond–Blackfan anemia References [ edit ] ^ Online Mendelian Inheritance in Man (OMIM): 609135 External links [ edit ] Classification D ICD - 10 : D61.0 ICD - 9-CM : 284.0 OMIM : 609135 MeSH : D029502 v t e Diseases of red blood cells ↑ Polycythemia Polycythemia vera ↓ Anemia Nutritional Micro- : Iron-deficiency anemia Plummer–Vinson syndrome Macro- : Megaloblastic anemia Pernicious anemia Hemolytic (mostly normo- ) Hereditary enzymopathy : Glucose-6-phosphate dehydrogenase deficiency glycolysis pyruvate kinase deficiency triosephosphate isomerase deficiency hexokinase deficiency hemoglobinopathy : Thalassemia alpha beta delta Sickle cell disease / trait Hereditary persistence of fetal hemoglobin membrane : Hereditary spherocytosis Minkowski–Chauffard syndrome Hereditary elliptocytosis Southeast Asian ovalocytosis Hereditary stomatocytosis Acquired AIHA Warm antibody autoimmune hemolytic anemia Cold agglutinin disease Donath–Landsteiner hemolytic anemia Paroxysmal cold hemoglobinuria Mixed autoimmune hemolytic anemia membrane paroxysmal nocturnal hemoglobinuria Microangiopathic hemolytic anemia Thrombotic microangiopathy Hemolytic–uremic syndrome Drug-induced autoimmune Drug-induced nonautoimmune Hemolytic disease of the newborn Aplastic (mostly normo- ) Hereditary : Fanconi anemia Diamond–Blackfan anemia Acquired: Pure red cell aplasia Sideroblastic anemia Myelophthisic Blood tests Mean corpuscular volume normocytic microcytic macrocytic Mean corpuscular hemoglobin concentration normochromic hypochromic Other Methemoglobinemia Sulfhemoglobinemia Reticulocytopenia This article about a disease of the blood or immune system is a stub .
    CAD, UMPS, RPS19, RMRP, LPIN2, ADA, DHODH, LOH19CR1
  • Lynch Syndrome Medlineplus
    People with Lynch syndrome also have an increased risk of cancers of the stomach , small intestine , liver , gallbladder ducts , urinary tract , brain , and skin . ... Individuals with Lynch syndrome typically develop cancer in their forties or fifties. People with Lynch syndrome may occasionally have noncancerous (benign) growths in the colon, called colon polyps . ... Frequency In the United States, it is estimated that 1 in 279 individuals have a gene mutation associated with Lynch syndrome. Causes Changes in the MLH1 , MSH2 , MSH6 , PMS2 , or EPCAM gene have been found in people with Lynch syndrome. ... Learn more about the genes associated with Lynch syndrome EPCAM MLH1 MSH2 MSH6 PMS2 Inheritance Pattern Lynch syndrome cancer risk is inherited in an autosomal dominant pattern , which means one inherited copy of the altered gene in each cell is sufficient to increase cancer risk.
    MLH1, NRAS, APC, MSH2, DCC, MMP2, SMAD4, PIK3CA, SMAD3, CHEK2, BRAF, CTNNB1, TCF7L2, BUB1, TP53, FGFR3, KLF5, EP300, KDR, MSH6, IGFBP3, AKT1, ABCB1, KRAS, RET, POLD1, POLE, STK11, NAMPT, SLCO1B3, EYA4, BUB1B, SYNE1, EVL, ABCA1, LGR6, ABCB5, DACT1, PRKD1, TCERG1L, IL6ST, PRKCE, PMS2, COX1, COX2, SH3TC1, GUCY1A2, RNF182, PPARG, MLH3, AXIN2, TGFB1, BMP4, GREM1, MCC, CD109, CDH1, PTPRD, SMAD7, HAPLN1, MUTYH, ARID1A, GNAS, DLC1, CCND2, RHPN2, FEN1, LRP1, LPAR1, SLCO2A1, VTI1A, HHIP, TET2, POLD3, TMEM238L, LAMC1, PDGFRL, CUBN, ZMIZ1, NXN, PROM1, XRCC1, EGFR, FADS1, ERCC2, SMAD9, SFRP2, FLCN, PTEN, SFRP1, DCLK1, FADS2, CCND1, ABCG2, PTGS2, SMAD2, SPARC, BCL2, CXCL8, CALR, TYMS, IGF2, TFPI2, CYP1A2, TNF, TLR4, BOC, TLR2, CASP8, MTDH, PARP1, TGFBR2, TGFBR1, CYP1B1, LGR5, FN1, SATB2, TNFSF10, ESR2, AURKA, SRC, WIF1, MYC, DPYD, YAP1, MMP1, CHD1, FBXW7, LEF1, ALDH2, RNF43, GSTM1, ABCC1, NQO1, ODC1, NME1, CYTB, GUCY2C, ND4L, KRT20, MTHFR, TYMP, MTRR, TGM2, ADH1B, NTHL1, BIRC5, TIAM1, ATG5, WNK1, EPHA1, ZEB2, TNFSF13, BMP2, CSF2, SOD2, RRM2, MIR26B, PRKCB, EXO1, MIR106B, AKAP12, FPGS, IDH1, KL, ING4, CSE1L, TLR9, GGH, AKR1B10, CDO1, MPO, MIR93, ACKR3, DHFR, SLC19A1, MMP11, WRN, TK1, GALNT12, KLF2, ABCC3, KMT2C, STRAP, NR4A2, PRKCZ, CHD5, AMACR, ABCC2, PPP2R1B, AKAP9, GATA5, ATAD1, MIR130B, GAPDH, FAT1, RPS6KB1, FOLH1, EPHA3, SESN2, SELENOP, ZNF217, MIR1271, TFRC, BMPR1A, MKI67, TP63, IRS4, CYP2A6, EIF3H, DPEP1, CAPN10, PDGFD, POSTN, TCN2, XAF1, TCF3, LIFR, CFTR, TPX2, PYCARD, PTPRU, LAMA1, ABCB6, CPE, EFEMP1, ARNT, RTN4, RASSF2, RASAL2, BRINP1, APC2, UMPS, SFRP4, EPHB6, SRSF6, TNS4, SELENBP1, PRIMA1, PER1, TENM1, ACSL4, IFNA1, NUSAP1, TRIM28, CTNND2, MTHFD1L, NTNG1, ABCC5, ASAP3, ABCC4, SLC12A5, SLC29A1, EPHA7, SOX17, CENPH, MCRS1, GPNMB, CD9, ZKSCAN3, ACSL5, FZD4, ERCC6, CUX1, CAD, GPX4, CACUL1, SCG5, GATA4, ADAMTS15, PTPRS, PRPS1, SERPINB5, BMP6, GSTM3, GTF2B, P2RX7, NME2, ACACA, ABCA4, TBX1, VWA2, RARB, LRP2, RASGRF2, APOB, RHEB, DDIT3, ACIN1, TXNRD1, GRIN2A, CHL1, FBLN2, HRH1, SFRP5, ATP7B, UNG, ZNF292, NEURL1, SLC11A2, HK3, CD226, FOXH1, GNB4, DHRS2, COL3A1, ADAMTSL3, PTPRT, NFATC1, GLI3, SDF4, CD248, NF1, FBN2, UQCRC2, NR3C2, CD93, CD46, ADORA1, EIF4G1, OBSCN, GHRHR, ADAMTS18, QKI, NCR1, GSE1, SKIV2L, SF3A1, DPYSL2, CDC14A, CTBP1, LIG3, PPP1R14A, F5, FOXL2, KDM6A, RUNX1T1, DMKN, TRPM7, OTOP2, CABLES1, TNFRSF9, ANP32A, BRF1, IFNA2, LY96, PCSK2, ST8SIA4, ABCB4, PRSS1, VPS13A, TTLL3, PKHD1, SETBP1, HDC, NRCAM, ADAM19, ABCB10, ODAM, LRRC3B, LDB1, UHRF2, CSMD3, OVGP1, GNB5, UNC13B, DPAGT1, OSBP, ADAM29, DNASE1L3, DLG3, ARFGEF1, MKRN3, DMD, ZNF155, DNAH8, NODAL, AKAP3, ALDH1L1, DSTN, FANCG, NID1, NELL1, CAMSAP2, LIG1, AGTPBP1, LAMB3, KCND3, KCNH4, ABCA6, ABCA5, KCNA10, CBX5, PIK3R5, HTR5A, ISLR, IPP, ZNF43, FCN1, RAB38, LMO7, LPIN1, NCDN, CNKSR2, NDUFA1, MYO1B, TP53TG1, TFEC, DEFA4, PPM1E, HOXC9, HOXD1, MCF2L2, H1-4, DIP2C, MAP2, HOXD9, SNRNP200, MAP1B, MAF, H1-5, CALCOCO2, ZNHIT1, WNT8B, SNRPB2, SLCO1A2, GABPB1, PAX8, MCM3AP, GABRA6, SMTN, SLC1A7, KALRN, ARHGEF1, GALNS, SLC33A1, ZMYM4, SCNN1G, KCNB2, SCNN1B, RPL6, ABCE1, RCN1, SORL1, SPTBN2, CDKL5, H2BC14, TUBB2A, STAM, FHL3, MLF2, ICAM5, RBM10, GFI1B, FLNC, OR1E2, SULT2B1, HAT1, TCOF1, DCHS1, ABCB11, ETV1, NPAP1, ETFDH, ABCC8, RBP3, RALGDS, DNALI1, BCAS2, PPOX, EDA, GRID1, GRID2, GRIK3, PMM2, GRM1, EFS, PKNOX1, PRG2, TFG, ABCA10, ABCA9, ABCA8, ZNF232, CORO2B, PGM1, PEG3, FCN2, PQBP1, AKAP6, STARD8, MYOT, RAB5C, ABCG1, PPM1F, ZNF432, PZP, ACAP1, CLSTN3, ABCD4, NPBWR2, ABCD3, JAKMIP2, PTPRN2, PSMC5, PSMA2, PAN2, P2RY14, PROS1, NDST3, KDM2A, EML2, ZNF442, CEBPA-DT, SLC66A2, PREX2, CBFA2T3, BPIFB2, TRAF3IP3, ZSCAN16, PBX4, SLC44A4, LAS1L, CAPN6, FBXO30, TOMM40L, TMEM164, HPS3, LZTS2, CCDC62, CACNB2, CACNB1, PIGO, LMNB2, IGSF21, CCNB3, FAM110B, ZNF804A, MYLK3, DSEL, OLFM2, ZFP36L2, CSRNP3, MMRN2, DSCAML1, ZNF385D, NLGN4X, ZNF624, ZNF471, RELCH, CDH7, CDH5, VPS18, HIVEP3, TSKS, EXOC4, DUSP21, DMRTA1, CLSTN2, LRRC4, NCAPG, MS4A5, CHST8, GMCL2, CDH22, ARAP3, PLPPR2, BCL11B, SLC26A10, BOLL, CYREN, GDAP1L1, ZSCAN5A, RIC3, PARP8, SFXN1, ERI2, OMA1, C8orf34, SPNS3, PDILT, AMER2, GJD4, FERD3L, ITPRID1, TTLL10, STK32C, ABCC6, ACTL9, ATP11C, KRT73, CD300E, KRTAP10-8, RASL11A, CCDC9B, CFAP77, C12orf76, AMTN, ANK2, AMPD1, ABCD2, ADORA3, ZBTB8B, ADCY8, ADARB2, MIR1273C, LINC00673, ABCA3, AMZ2P1, SPAG17, VSTM4, ZNF560, CSNK1A1L, SPACA7, B4GALNT2, CYB5D2, NLRP8, KDF1, CPO, EVC2, ZNF572, FRMPD2, SYT9, PHETA1, ZNF480, ZNF569, HTR3C, ABCC13, PUS10, C2CD6, ATP6V1E1, WDR49, CNTN4, JAKMIP1, ABCA13, IQUB, ERICH1, ZNF540, LONRF2, UGT3A2, LRRC47, SLC22A9, PAIP2, PANK4, ZNHIT6, CTSH, PHIP, EDRF1, ARHGEF10L, COL4A6, PCDH11X, VRTN, JPH3, TMEM140, SLC22A15, DNAH3, ZDHHC7, MFN1, INTS13, CCAR1, CINP, CCDC93, SCN3B, GPR87, AMDHD2, SHANK1, NT5C, DONSON, PDZRN4, ERGIC3, CNTN1, TSPEAR, ELOA2, ANAPC4, ZZZ3, SNX8, PEX5L, SETD4, TNNI3K, ETAA1, SALL3, TBX22, CPAMD8, FBXL2, WNT16, KCNQ5, ZDHHC2, SIGLEC7, FSTL5, ABCA12, PAK6, MFF, COL7A1, WAC, RPAP1, CABYR, CNPPD1, SDCBP2, HR, SACS, CORO1B, RNPEPL1, AGER, BAX, CD59, NFE2L2, BRCA2, CCAT2, CDH3, FGFR2, BCL10, SLC22A3, PTPRJ, STS, PLA2G2A, LRIG1, CASC8, COLCA2, HLA-B, NOS1, LAMA5, PCAT1, KRT8, MPRIP, SH2B3, COLCA1, CYP17A1, WWOX, ATF1, EDN1, BMP5, GATA3, UTP23, MZF1, NOTCH4, TMBIM1, CDKN2B-AS1, FMN1, FKBP5, RAD54B, RTEL1, ERAP1, RALY, SHROOM2, C11orf53, TNS3, ELOVL5, TNS1, ETV6, BRIP1, EPHA5, CHRDL2, TFEB, HLA-F, SBF2, HNF1B, HSPA12A, SYMPK, MIR193A, MIR195, MIR20A, MIR17, OGG1, NOTCH1, MIR200C, MIR200B, MIR203A, MIR183, MIR18A, MIR182, GPR143, NTRK1, NDRG2, MIR155, PMP22, PIK3CD, PIK3CG, PKM, PRPF31, PLAU, PLK1, ZBTB20, SIRT1, MALAT1, MIR150, GSTK1, TICAM2, SLC6A18, MACC1, ECT2L, POU5F1, POU5F1B, PPARD, PIK3CB, C17orf97, LINC00511, LINC01121, SERPINE1, MIR149, MACF1, PAK1, PRKN, PCNA, MIR148A, MIR146A, PDCD1, MIR145, MIR143, MIR141, MIR139, MIR137, MIR126, LINC01194, POLDIP2, MIR106A, MIR31, MIR206, LGALS3, LINC01475, EP300-AS1, KCNH1, CRTC3-AS1, KISS1, KIT, TMEM220-AS1, C5orf66, LEP, OBI1-AS1, JUNB, LINC00446, FSBP, RTEL1-TNFRSF6B, COMMD3-BMI1, LRP6, LSAMP, EPCAM, BAALC-AS1, TMED7-TICAM2, JUND, JUN, SMAD6, IL6, H3P10, H3P23, MTCO2P12, IGFBP7, IL1A, IL1B, IL2, LINC01173, IL4, LRP1-AS, JAK2, LINC02264, IL10, CCND2-AS1, IL17A, LINC01500, IRS1, LINC01708, LINC01917, ITGB1, SMUG1, CD24, MIR21, MUC2, MST1, MIR34B, MIR34A, MIR30A, MIR29B2, MTR, MIR29B1, MTX1, MUC1, MUC5AC, MIR17HG, MIR29A, MIR27A, MIR23A, DRG1, MIR224, MIR221, MIR214, NFKB1, NHS, MSH3, MIR133B, MZF1-AS1, CRNDE, RNF19A, HOTAIR, PNKD, UCA1, MCL1, POU5F1P4, MDM2, MET, MGMT, POU5F1P3, MRC1, MIR497, MIR451A, MIR375, MMP3, MMP7, MMP9, MIR338, MIR135B, MPZ, DCBLD1, SGSM3, FAM182A, ZNRD2, USHBP1, TMTC1, CIB1, FSD1L, CXCR4, ARHGAP24, CABLES2, REEP5, AIMP2, C1orf21, B9D2, HMGA2, CD276, UGT1A7, L1TD1, NDRG1, KCNIP4, PPP1R2C, UGT1A1, REG4, EFCAB2, OR1J2, XRCC3, IL23A, TWIST1, TXN, SLC22A16, TOX2, DCTN6, TDP2, TUBA1C, SPSB2, GDE1, VDR, VEGFA, VEGFC, EZR, VIM, WNT5A, XPC, AHSA1, ACTRT3, TTC22, BICC1, GPATCH1, FAM193A, TRAP1, FRY, ACTR1B, GNG12, KLF4, NAT2, GAS5, EIF4ENIF1, ADIPOQ, GRAP2, NTN1, SCO2, DIP2B, GDF15, CLOCK, PREX1, CHPT1, SLC12A9, KIAA0355, PTTG1, NOD2, MYNN, FSD1, DHDDS, NANOG, TNKS, BAALC, BECN1, PLEKHG6, RNGTT, MUL1, ACOXL, CLEC3A, NR1I2, SPHK1, CRTC3, HERC2, MBD2, HSPB3, CFAP44, CLDN1, TRPC6, TANC1, TP73, CXCL12, RAF1, PLCH1, SPIN3, DDX53, IGF1, PCNX1, RELA, REV3L, RNF4, RETREG3, ROS1, DENND5B, CBLL2, BABAM1, S100A4, SATB1, ATXN2, CD274, CCL2, RAD51B, RAD51, RAC1, ZMIZ1-AS1, MAPK1, MAPK3, MAMSTR, MAPK8, MAP2K1, MAP2K7, PRNP, NEAT1, PSG2, HPGDS, ACAD8, PSMD9, PTGS1, TBC1D9, RTKN2, PVT1, MYO16, PDCD4, CCL20, ZNF827, TOP1, NEK10, TCF4, TBX3, SLC25A26, ZEB1, SMR3B, BTBD9, TERT, TFF3, IL17F, LILRB1, LIMA1, HSPH1, TIMP1, TIMP2, TIMP3, SEPTIN9, MFSD4B, IL33, TENM3-AS1, ADIPOR1, STAT3, STAT1, SNAI1, ZHX2, IL22, SCAF8, FOXP3, SLC2A1, CBLN2, RASSF1, RIPOR3, FSCN1, SST, TMED7, SLCO6A1, SOX2, SOX9, PTP4A3, SPP1, PPP1R21, PIGU, IGF1R, NAT1, E2F1, CYP2C9, ATM, HSP90AA1, COL4A2, FGF2, BMI1, HSPB2, CRK, DOCK3, CDC42, RUNX3, CD34, HSPB1, CYP24A1, ETS1, RUNX2, CYP2E1, MYRF, ERCC1, DNMT3B, EREG, DNMT1, CDX2, ALOX15, JAG1, EPHA2, CEACAM5, MTOR, CCK, ERCC5, DLD, COL2A1, TMEM258, CRP, ESR1, EGF, HSPA5, COL11A2, HSPA4, ACTB, HPGD, GSTT1, HRAS, CLDN7, CEACAM7, GSK3B, BAAT, GABPA, APEX1, GSTP1, BRCA1, CD68, HES1, CEACAM3, FANCC, ACE, FANCE, CHEK1, GBAP1, GAST, EZH2, FCGR3A, CASP3, FASN, FAP, COX8A, CDK1, XIAP, CASR, CD44, F3, CXCL1, CDX1, GSTM2, HFE, AREG, CDKN1B, CDKN1A, HIF1A, HMGB1, FOSB, FOS, MAPK14, HLA-A, ICAM1, ALDH1A1, EPHB4, CLU, FLT4, EPHB2, IFI27, CDK4, ALB, NR0B1, FLT1, GLI1, FOXM1, CTLA4, EPAS1, FOXO3, IFNG, CYP1A1, CDK8, CDKN2A, FHIT, FGFR4, HGF, ERBB3, ASCL2, HNF4A, ALK, ERBB2, GH1, CREB1, LCN2, SULT1A1, MIR204, CAV1, EPHX1, PSMD10, MIR125A, PPARGC1A, PRDX2, ZFAS1, UNC5C, UGT1A6, ARSA, CXCR3, MIR552, PDGFRB, MYD88, UGT1A, MIR223, AIM2, EIF4E, CDK2, DKK1, SYT1, THBS1, SKP2, LOX, MIR378A, KLF6, NTS, XIST, STAT5A, FZD7, REG1A, MIR215, PROX1, BBC3, CCAT1, MMP13, HMOX1, INSR, NOS2, TNFRSF10B, TNFRSF10A, CNR1, HDAC2, CD82, MIR32, MMP14, USP22, HLA-G, HAVCR2, SOCS1, NDRG4, DNMT3A, GORASP1, HPP1, AGT, SETD2, FMNL2, SNHG6, MYB, FSTL1, ALCAM, NF2, MSMB, MIR140, AKT2, TUG1, MIR222, DPP4, CEACAM1, MIR196B, KLRC4-KLRK1, MEG3, AGR2, CPOX, ANGPT2, ANXA5, MIR144, CCNB1, WNT2, SOX4, TMSB4X, GC, HDAC9, FOXK1, PDXP, PLAGL2, DCN, ERBB4, TNC, DKK4, PXN, MTA1, COX5A, TMPRSS13, LATS2, CD163, IL23R, EPHB3, KEAP1, SNHG1, PRKCA, MBD4, PLA2G4A, CDH13, CCN2, KLRK1, S100A9, LMLN, AR, CRYZ, SOCS3, CLDN2, SLC9A3R1, PRKAA1, IL13, ST6GAL1, KCNH2, STAT5B, FAS, AKR1A1, MIR15A, EGR1, PTPA, MIR96, HDAC1, ATF3, ST13, UVRAG, MIR486-1, ITGA5, NR1H2, AQP5, CXCL10, HMGA1, LRG1, NOS3, CDKN2B, MIR320A, NUDT1, ALOX5, ROBO1, MIR19A, CEMIP, ADAM17, CIP2A, FGFR1, ROCK1, MIR499A, SQSTM1, CYP2B6, MRE11, IL18, ANO1, RETN, TET1, OLFM4, KCNQ1OT1, SELE, NLRP3, PIK3R3, LDLR, CCR6, BIRC3, CCN1, XRCC6, LGALS4, SMARCA4, SUB1, PECAM1, PITX1, BNIP3, SLIT2, SMC1A, SPOP, SIX1, GSTA1, MIR760, FOXQ1, AXIN1, CXCR2, MIR10B, MIR142, KPNA2, BMP3, GATA6, TAZ, CCL5, MYCN, CCL21, PEBP1, IRS2, MIR22, H2AX, COPS5, ACVR2A, ANG, SCD, TRIM21, SDC2, AFAP1-AS1, KRT19, MIR608, THAS, KLK6, RARRES2, PTK2, NEDD9, CTSB, CA9, GLS, PTCH1, TMEFF2, UBE2C, PGR, CCKBR, REG3A, ANXA10, CASP2, PLG, KDM1A, PDCD1LG2, SET, SOD1, SOAT1, SGK1, HLTF, SNAI2, VANGL1, COL18A1, BSG, DDX3X, PRRT2, MIR382, XRCC6P5, UHRF1, NOTCH2, SDC1, RNASE3, TAGLN, PRKDC, MIR34C, BRD4, PRKAB1, PRKAA2, FTH1, MIR455, BLM, ADH1C, CYP19A1, PPARA, VPS51, GRN, PLCE1, PMS1, LIN28A, CST1, HSF1, PER2, BDNF, PPP1R13L, GAB2, FCGR3B, CHFR, ITGB3, TPM3, CFLAR, MIR210, ERCC4, KHDRBS1, MUC4, TP53BP1, CDKN1C, MST1R, HTC2, CLCA1, STMN1, LAG3, MME, RAD50, APOA1, ETV4, XBP1, LASP1, LEPR, BCL9, MIR185, CYP2W1, XRCC2, F2RL1, HNRNPA1, GOLPH3, VIP, MIRLET7B, IFNAR1, APAF1, TKTL1, TACSTD2, ELAVL2, BCAT1, CASC2, ADIPOR2, PIWIL1, FOSL1, NBN, MIR27B, PANDAR, ILK, B2M, THBS2, IDO1, IL1RN, MIR491, SMAD5, STC2, CXCL5, APOE, CREBBP, MIR372, NCOA3, SEMA3F, ADGRE5, KDM3A, PLCG1, SHMT1, MIR216B, SHH, MIR429, SLC1A5, ADGRE2, LOXL2, PLA2G1B, SERPINA1, MIR424, NLRP2, BACH1, DUSP4, MIR873, PGF, TRIM13, PPM1D, HLA-E, DICER1, L1CAM, AICDA, NUP62, PRL, CDK9, REN, TBPL1, RSPO3, DANCR, NOX1, RASA1, MIR622, RHBDD1, SALL4, CTSD, ZEB1-AS1, AURKB, PTBP1, RAD21, MIR532, GJA1, RAB1A, XPR1, IGFBP2, RFC1, EIF4EBP1, MIR202, POTEF, RSPO2, APRT, CD55, STK31, GRB2, DAB2IP, CYP27B1, NR1I3, CCR2, CYTOR, ANGPTL2, CACNA1G, LINC00460, KCNQ1, IQGAP1, NRP2, JAK1, SNHG14, SNHG15, PRKAR1A, ITGA4, CRY2, FABP6, MIR543, SERPINF1, MIR10A, WEE1, RUNX1, WNT1, CD36, TOP2A, TCF7, FOXF1, CHI3L1, PAEP, DCTN4, MIR301A, TNFRSF1B, GZMB, FOXC1, SRY, MIR122, TMEM8B, SMYD3, MIR216A, STAT6, MMP12, HDGF, SYK, CBS, TAC1, AKR1B1, HP, MIR181A2, HOTTIP, MIR211, MIR15B, FGF7, CDCP1, MAP3K7, HOXA9, HMGCR, STIM1, TFAM, SLC35A2, NFATC2, MAX, FLNA, FOXO1, SPINT1, GTF2H1, VTCN1, NEK2, TFF1, SNCG, ATN1, MIR23B, MIR107, ANGPTL4, HOXB13, PTPRZ1, PVR, POFUT1, TPI1, MIR574, MIR212, BGN, NOLC1, TFAP4, PER3, SOCS6, TGFB2, CTAG1B, PTPRC, ADAM28, MIR582, HDAC3, MIR200A, MIR33A, CCN6, MIR197, UCHL1, NRP1, KISS1R, PTPN13, LYPD5, ADM, BTG3, RNH1, RARA, PTPN11, TEK, HGS, RPH3AL, LPAR2, SLC16A4, ELAVL1, TFDP1, LATS1, MOK, MIR217, INPP4B, CXADR, GHR, PTGES, ARHGEF2, IL24, TCF21, MIR30B, TWIST2, TSPAN8, GEM, TLR3, CXADRP1, TFPI, HNF1A, GDNF, RIPK3, ARR3, RPP14, FADD, C12orf75, FILIP1L, PAK4, MIR28, DRD2, SIRT2, E2F4, ANXA3, CDK2AP2, MIR362, MIR483, MIR363, SHMT2, DUSP10, BMP7, PRDM2, RECK, CUL4A, FCGR2A, SPG7, MIR330, MMRN1, MIR425, MIR373, PRMT5, BAK1, SMO, DUSP2, DECR1, SLC16A1, KAT5, MIRLET7E, BAG1, MIR340, DVL2, LIN28B, IKZF1, MIR422A, FUT6, MIR100, RNF41, ECT2, TIMM8A, PDE5A, MIR494, BCL2L11, CTHRC1, SAT1, RIPK1, MIR519D, FEZF1-AS1, ESRRA, TNFSF9, KLK3, WNT3A, ATOH1, FGF13, PLK2, MIR503, MIR506, UGT2B7, AFP, VHL, BCL2L1, IGF2BP2, IFITM1, MAP2K4, MIR485, XRCC4, SSRP1, SELP, MIR132, XPA, KDM4B, PDIK1L, MIR490, NPRL2, PHLPP2, EFNA1, DAPK1, MUC12, GATA2, CYP2C19, CTAG1A, HOXA4, CXCL16, HSPA9, KIR3DL1, CEBPB, AGO2, MARCKSL1, CASC11, CRYAB, CDC73, TP53COR1, ABHD5, MYBPC3, COMETT, MIR650, MIR638, DKK3, MYH11, UGT1A10, MYOD1, ITGAV, POLB, CEACAM6, NCAM1, MAP3K8, ITGA2, LTA, FTO, RETREG1, PBK, LAMTOR2, LGALS1, ESRP1, LDHB, MCTS1, CASP7, SLCO4A1, MSI1, MSX2, GPX1, GPX2, TENM3, PON1, CMAS, MCAT, FAM172A, NR4A1, BLACAT1, SNHG16, SLCO4A1-AS1, HSD17B1, CRY1, GAEC1, LPA, CMA1, CDA, HOXD10, MIR708, CDH17, WLS, IL12B, NFKBIA, CCR7, PCDH10, MDM4, PLS3, PITX2, RMC1, PNPLA2, HOXB7, MIR1290, CMPK1, H3P8, MDK, PLAUR, HSD17B7, CDK6, ZBTB7A, CEACAM4, HK2, YBX1, CD47, CCR5, DEPTOR, NOTCH3, CBR1, MIR944, HIC1, TLR7, NT5E, SF3B6, MIR590, CSNK1E, NEUROG1, HACE1, TNFRSF11B, RAB8A, MIR130A, FRTS1, XRCC5, MTHFD2, HNRNPC, NAT10, UCP2, MIR196A2, PGPEP1, UBE2N, CISH, MIR191, MIR192, BCL3, KMT2A, GNA13, FGF4, CTCF, HOXA5, TYRO3, HOXA@, MIF, VCAM1, SPRY4-IT1, CD86, PINX1, FGA, FGF9, WNT11, WT1, BANP, MFAP1, MIR186, UPP1, CD28, UCK2, ST6GALNAC2, PTPN12, NR2C2, CD14, AHR, NR2F2, TFF2, CDHR5, CYP2R1, TOMM34, NEO1, NEDD4, MIR198, TBL1XR1, CCR1, TIA1, LINC01672, FOXE1, MIR25, RAB40B, CKAP4, TERF2, TEAD1, HLA-C, TDGF1, TDG, TRBV20OR9-2, KIF2C, MIR302A, MIR1260B, TCF12, NLK, DMBT1, AZIN1, TAP2, TAP1, HOTAIRM1, FOXD1, UGT1A8, HPSE, MSX1, MIR199A1, MIR199A2, MT1G, MIR19B1, TTK, FOXA1, TSC1, FHL2, TRPC5, MTHFD1, ALOX12, HSP90B2P, TRAF6, ZG16B, TNFAIP3, ANXA2, DNASE1, MIR205, TPT1, CKS1B, FGL2, HMGCS2, PTPN6, DHRS11, VEGFD, MUC6, MYCL, MIR219A1, UGT1A4, YWHAZ, RASSF7, CHGA, ANKRD36B, CCAR2, MTSS1, VNN1, TRIB3, TUSC7, AQP1, RSPO1, PCBP4, BCL9L, IRF2, RASSF6, GOPC, ITGA6, F2RL3, EIF3E, HNF1A-AS1, HTR1D, APLN, ITGB2, HOXA-AS2, HNRNPDL, ATP5F1A, METTL3, IL21, DLEC1, KCNN4, SIK1B, SETDB1, CES2, HSPD1, CDR1-AS, ZNF410, ERN1, MELK, EIF6, NFE2L3, PRC1, MRPL28, PDLIM7, IDH2, IDUA, ARG1, ADGRF5, CTTN, CDK5, ENG, KIDINS220, INHBB, IGFBP4, ZFYVE9, ADGRG1, IFNA13, IGF2R, LONP1, PPIG, TINCR, IL2RB, BUB3, IL4R, CXCL14, EPO, ING2, FOXK2, TP73-AS1, ARNTL, IL16, IL15, SLC16A3, AIFM1, ATG12, RHBDD2, IL7, H3P9, ROCK2, KIF22, AKT3, TFAP2E, MARCKS, TNFRSF19, CDK2AP1, DSC2, MLRL, ROBO3, SPON2, MAD2L1, TM4SF1, ABI1, LUM, ANAPC10, DUSP5, TUBB3, APBA2, F9, CNPY2, CARM1, MAP6, HDAC7, MLLT10, ZIC1, MECP2, ZNF148, HOXB8, CD40, HOXB9, ZNF654, ACVR1, MCM2, USP7, DEK, MBL2, CEACAM8, TUSC3, ADHFE1, NANOGP8, LMNA, E2F5, SIK1, PLB1, HSD17B13, HUWE1, ASIC2, UBA2, XPO5, GJC1, NUMB, SULF2, SGO1, EWSR1, KRT7, MECOM, SAV1, HDAC6, AQP8, EEF1G, MSLN, EDNRA, F7, PLA2G6, GPA33, SPARCL1, GDF11, NR0B2, AZGP1, DYRK2, PRNCR1, ROR1-AS1, DHX32, LDHA, PAG1, RPSA, LAMC2, GRHL2, IFNGR1, DDX5, MIR449A, TRIM29, B3GAT1, ATF6, MAP1LC3B, RAB3GAP1, MIR630, MIR874, GPC1, GSR, ZG16, PIM1, MIR885, OPN1LW, PIK3R1, DDX58, GPI, AJUBA, MIR20B, SHBG, MIR433, GRP, SRSF3, MAPK9, ADRB2, DUXAP9, ANTXR1, FUT8, PDPK1, SLC46A1, NDUFA13, SNCA, PDGFRA, PLAAT4, PDK1, IKZF3, BMPR2, PDK4, CASP9, SMARCA1, PUF60, RRM2B, SLIT3, KLK10, HNRNPA1P10, BAMBI, CPT1A, MIR361, MUC16, RBL2, MIR384, SLC6A4, SLC25A3, SNHG12, SNORD14C, MIR92B, SLFN11, MIR761, RPN2, MIR146B, DAP, MIR675, SIRT3, BTG1, SIRT4, MIR769, MIR495, SIRT5, PPP1R1A, SNORD14D, SOX7, TRAPPC9, DACH1, RPS18, ATG4B, RPS24, NBEAL2, HIPK2, NOB1, PHLPP1, PPBP, CCL4, CAPS, CYP3A4, CAPN2, ATF2, PLD2, MIR147B, SLC39A14, SNX10, RASSF10, IL37, SNORD14E, NR3C1, NKD2, CRIP1, CXCL11, PRRX1, TNIK, PCDH17, KLF9, NXT1, MAGT1, PODXL, CCL19, RPE65, CCL15, BTF3, MIR342, SLC25A21, SNORD35B, ARL11, SREBF1, PAX6, CTNND1, ADAMTS5, CPEB4, PTK7, NTSR1, ANIB1, AKAP10, MIR592, CSK, PBX3, GALNT6, MIR7-3, PADI2, MIR7-2, MIR324, TAS2R38, GCLM, ROR2, LINC00328, BMP1, DOT1L, MIR598, MIR551B, CXCR5, COMT, RAB27A, MIR1246, GCLC, GSDME, OGN, FURIN, PTX3, PIM3, STC1, MIR600, ADAR, STEAP1, WWTR1, PSMB8, MIR7-1, FOXD3, MIR339, COL1A1, GUCA2A, MIR335, SIRT7, PTPN3, FOXD2-AS1, SYP, MIR328, SPINK1, PTPN1, PSMA7, SP1, PART1, PTPRG, FRZB, VCAN, EDNRB, MAP3K21, SRPX2, GSTO1, SELENOS, CTNNA1, RANBP9, KRT23, ITGBL1, ATP6V0C, LCS1, BCAP31, RGCC, EGFL6, LYPD4, MTA3, EMX2, DPPA2, EML4, CENPA, BEX2, IL17C, CDC6, CDC25C, PDCD6IP, SUZ12, FGF21, MAP4K4, AXL, NAV2, ABCC10, BZW2, APOM, DCP1A, SPZ1, ALX4, MIIP, RASGRP1, CYP3A5, CYP7A1, TGFBRAP1, ATR, EEF1A1, TSPAN1, ARL4C, ROPN1L, PROK2, WASF2, ATP6AP2, ENO1, ZNF518B, MIB1, TDP1, FAM126A, CRMP1, EEF1B2P2, AVP, EFNB2, CAPNS1, EBI3, RABGEF1, RCC2, FBXO8, ARHGEF12, RPPH1, BHLHE22, CA8, MVP, ATP5PF, ANKS1B, FANCM, PARP6, SND1, ARNTL2, ORAI1, BAG3, KIF4A, IL17RA, TOX, EIF4A3, DLGAP5, CX3CR1, PNO1, PLA2G15, RNF40, ENAH, FOXP1, CALCR, ECRG4, NLRC5, MED19, CDKN3, MINDY4, CTSL, ASIP, CD177, CSF1, KLK5, PAK5, RGS6, CYTIP, IL17RC, NLRC3, EIF5A, CTSK, SPDEF, ASNS, PLXDC1, CDH10, LINC00467, ASPA, RAB3D, ASS1, PRSS55, TIGAR, CBX8, SPATA2, EIF2AK3, PROK1, LPAR3, BCCIP, CNRIP1, CA2, MEGF8, RPRD1B, KIF14, MPEG1, ARHGAP25, ABHD11-AS1, SNHG7, NDRG3, LY6G6D, SBDSP1, SNORD14B, CDK7, ZNF281, CDC27, HRH4, SEMA6A, CASP8AP2, EIF5A2, UBAP2L, NUAK1, PATZ1, TRIM14, ADAMTS3, ADAMTS4, CD2AP, FAM30A, MAEL, HAMP, RAD18, POT1, SPHK2, ARHGDIB, SLC2A4RG, FITM1, PDSS1, DKK2, RAB22A, MUC13, NUPR1, SLC5A8, TMPRSS4, ESRP2, DROSHA, SMOC2, CASP6, SRCIN1, ASPN, GGCT, CD3EAP, CLCA4, MGLL, AZIN2, TRPM8, POLR1D, GAL, MLXIPL, CLDN4, TMEM54, BTG4, BUD23, KLF8, SARDH, KLF12, CKS2, CD247, CORO7, LYVE1, SH3GLB1, MECR, DES, VASH1, CLDN3, PSMD14, SETD7, CMPK2, MAPRE1, TESC, FAM83D, CD209, USP39, TXNDC5, POLQ, FAN1, PLK4, IQGAP3, KLF17, YTHDF1, BCR, RUFY3, PLA2G3, STK33, CPT2, TP53INP1, MS4A1, BCYRN1, ASAP1, CAVIN3, EGFL8, TRAT1, PAF1, CAT, DDX56, ING3, COL6A3, HAND2-AS1, COPS6, SIX4, MAP3K20, CDC37, MAPRE2, NAA40, PEAK1, UBR5, TRAPPC4, IMMT, POLK, ISYNA1, PARD3B, NHEJ1, MFSD13A, LINC00472, WDR76, VTA1, TOPBP1, TRIM31, ESM1, SIRT6, COL1A2, SHC3, P2RY13, BVES, EHMT2, GALNT14, FAT4, IRAK3, CCNG2, CPSF4, JTB, FZD10, BRD8, CLN3, PABPC1L, SLC31A1, EGFL7, CORO1A, H4-16, LMTK3, SUV39H2, PALB2, TREM1, SLC25A22, RALBP1, RERGL, WNT10A, COL11A1, MYSM1, MARCHF1, BRS3, USP47, CKS1BP7, CD63, RASSF5, RACK1, PIAS3, ST3GAL6, ADGRB1, CARD9, DUSP1, ZC3H13, IL17RB, DSC3, TRPM6, VAV3, KDM4C, BATF3, MAD2L2, PDLIM2, CRTAP, TRPV6, RHBDF1, ZNF331, UPRT, AMER1, RNF183, IMPACT, SPART, NOD1, BTK, E2F7, SAPCD2, TRIB1, UCN2, CCDC88A, STARD13, SPRY2, C3, CTSC, MOAP1, SIGMAR1, FMNL3, E2F3, ITLN1, DDX27, PIWIL4, CD70, VSIR, TLR6, CGA, FERMT1, CRIP2, OTUB1, BAD, TSPO, STYK1, NEBL, DOCK2, ATG7, A1CF, OBP2A, TLR10, PDLIM5, ADAMTS12, TRIM3, DCLRE1C, CSMD1, VMP1, TXNIP, NDST4, PDPN, ANAPC1, NUCKS1, PRMT6, CHKA, SMURF2, IGF2BP1, GALM, CHRM3, RPIA, CELF2, CXCR6, SLC52A1, ATG16L1, BCL2L2, MOB1A, HNRNPLL, BST2, PRSS50, UBD, CRHR2, USP33, CD40LG, CDCA3, TCF7L1, BCHE, ANP32B, LINC00312, HTATIP2, SLC25A24, SCGN, PSPC1, SPEN, CXCL13, DNER, MRGBP, ENTPD1, SLC26A3, CD38, SLC34A2, PSAT1, DDB2, CD8A, APOD, RBP4, MIR367, SRI, FUS, MIR148B, MIR3666, MIR302C, SPTAN1, HLA-DRB1, SPOCK1, MIR326, SPN, MIR331, FUT4, NEU1, SNX1, G6PD, TLE5, SSAV1, LINC01133, MIR99B, CBR3-AS1, PANTR1, MIR98, NR5A2, MIR99A, STK3, STAT4, SSTR2, EIF2AK4, LUCAT1, NCL, MIAT, SSX2, SSTR4, NEUROD1, SMARCC1, AGTR1, SMARCB1, HNP1, GAS1, MIR452, MIR409, MIR410, NONO, MIR488, MIR489, GATA1, CX3CL1, MIR511, CCL24, CCL22, CCN3, CCL11, MIR18B, PGM5-AS1, H4C15, MIR3163, ACYP2, SLC22A5, SLC22A4, NFIL3, MIR466, NGF, MIR383, SIM2, SLC5A5, MIR423, DUXAP8, SLC2A4, DUXAP10, SKI, TAPBP, MIR30D, CCL3, LINC00707, WNT3, VWF, MIR4500, AMFR, MIR152, MIR154, HNRNPK, HNRNPD, MIR181C, ALPP, ALPI, MIR187, USP4, FOXA2, UBE2V1, FES, ANPEP, MIR136, CNBP, FBLN1, FBN1, MIR1-1, MAP3K11, TRIM25, FCGRT, ZFX, MMP16, ZFP36, HOXA6, YY1, MMP8, ANXA1, MIR4478, UBA52, HMMR, MYO6, FGL1, PPA1, FLT3, TFCP2, MIR29C, TFAP2A, TERF1, TERC, TEAD4, PPP1R11, TCP1, TCN1, FOLR2, FOSL2, MIR30C1, MIR30C2, TGFA, MVD, MIR296, TP53BP2, MIR199B, TTF1, TRAF1, HSP90B1, CRISP2, HMGB3, MUC3A, TGFBI, FOXF2, NKX2-1, FOXC2, TRIM37, THPO, AHSG, CCL7, SCTR, PTK2B, PIN1, PTN, PGK1, PGM5, PHF2, GLP1R, PTH, MIR597, PTGER4, PTGER2, GLUD1, PSPH, GMDS, PSMD4, MIR939, SERPINE2, PGC, MIR579, MIR577, GHSR, PDE4B, PDE4D, MIR411, RAD52, RAD51C, TRAP, RAB27B, GLI2, GJB2, PF4, GLB1, NECTIN1, KIR2DS2, PTPRK, MIR603, MIR942, PDE4A, MIR605, UTS2R, MIR663A, FXYD3, PLOD1, MUC5B, GPR42, PLXNA1, ARHGAP35, PPP2R2A, GGTLC3, MIR766, GGT2, POMC, HULC, GGTLC4P, PLD1, PLCL1, MAP2K2, MIR625, GNA12, MIR374B, HTRA1, KLK7, RELN, CXCL3, GOLGA2, MAP2K5, LGMN, MIR627, MIR629, GOT2, PRODH, MIR744, RAP1A, RAP1GAP, GBP1, ADRA1A, MIR520G, GCG, RRM1, RPS27, RPS20, RPS15A, MIR505, MIR508, HCC, RPLP0, RPL29, MIR1827, RPL22, OPA1, RPL10, RXRA, SORT1, NUP88, MIR181D, NPC1, NPM1, SCN1A, NPR3, HGD, ADRA2B, MIR498, DDR2, NRL, NTRK2, NTRK3, S100A11, ROR1, S100A10, LEF1-AS1, PURPL, PCYT1A, RP1, RCN2, MIR539, PAM, MIR544A, PAWR, RBM3, RBBP6, MIR487B, RB1, PCCA, LINC01630, RASGRF1, RARG, GGT1, GUCA2B, REG1B, GFI1, SNHG20, MIR1229, RORA, SNORD15A, GDF1, MIR1297, RNF6, MIR1258, OTX1, UPF1, RNASEL, NORAD, GGTLC5P, P4HB, REST, MIR1914, FZD5, MED1, BIRC2, CLMAT3, INPPL1, CUL1, OGT, PRMT1, ACP3, FOXP4-AS1, CBX4, PKMYT1, AP3B1, LINC00265, IAPP, LIPC, LIMK2, IREB2, PWAR4, LIMK1, KHSRP, ANGPTL1, LIG4, IRF1, IRF3, GPRC5A, CADPS, HCA1, CYP4F3, LTBP2, H4C14, H4C3, H4C8, HOXD8, H4C2, H4C5, IL1RL1, COX7A2L, ACTN4, H4C13, LOC110806263, MAFG, SNHG5, ILF3, HPS1, MAD1L1, CBFA2T2, ING1, ASPM, ABL1, LTBP4, TMEM189-UBE2V1, TMEM189, WSPAR, HSPA1A, H4C12, IRF7, JAG2, MIR6869, TRIM59, CASC19, FUBP1, RAB11A, ARHGEF7, TNFRSF6B, TRIM24, TPTEP2-CSNK1E, ANOS1, CDKL1, MIR6803, KIR2DS1, FGF18, SOCS2, CCN5, CBSL, DLX6-AS1, KSR1, GHET1, HSP90AB1, ACAT1, ESRRB, GACAT3, CCNA1, LBP, FBXL19-AS1, CISD3, EXTL3, LCT, DYNLL1, LCP1, EIF3G, ITGA1, PEA15, ACLY, HSPA1B, ITGB4, ITGA3, ITGA7, ITGAE, LAMB1, BTRC, HSPA2, ITGAL, CERNA3, PERCC1, ADGRE4P, H4C11, FASLG, H4C6, IFIT2, USP9X, CXCR1, FABP2, KITLG, HOXB6, MGP, MEIS2, H4C9, FABP4, H3P47, IGFBP5, GTF2H5, NNT-AS1, GCNT3, CIITA, SHOC2, HOXD3, BCAR4, MAPKAPK2, FZD1, IL6R, MEIS1, RICTOR, SLC7A5, MAP3K1, IHH, MEN1, MEP1A, IKBKB, H4C4, HAGLR, MFGE8, NRIP1, RHOA, COPS2, MELTF, ME1, ID1, APBA1, IL9, EPHA8, CCDC6, MBNL1, MIRLET7C, IL32, FEZF1, MATN1, MAS1, MIP, C2orf68, SNHG17, EPHB1, SLC16A7, ACSL1, OSMR, LINC00365, AANAT, H4C1, IFNB1, FZD6, CDR3, CXCL9, IL11, FAAH, MC4R, NCOA4, MIR1182, DYNLRB1, NUF2, MIR1288, CASP1, CBFB, MIR1307, H3P28, MIR1275, MIR1296, NUBPL, EPG5, ADD1, TP53INP2, IBD27, FAM3D-AS1, ZGLP1, MIR1295A, MIR298, JAM3, NRIP2, ADARB1, NCOA5, SCUBE2, SNORD12B, MED28, MIR1256, ULBP2, MIR1249, EFHD1, CXXC4, CAV2, MIR1247, ACADM, WDR82, RGPD2, MUC3B, SNORD126, ZNF398, ADD2, MIR454, CDK5RAP3, H19-ICR, PTBP2, MIR1976, SNHG8, NLRC4, CAST, CASC21, USP28, SLC25A25-AS1, OLA1P2, MIR365B, CASP5, CDH4, XIAP-AS1, ALPK1, GDPD5, LOC112543491, LINC02605, STIM2, HM13, CDH15, MIR877, CLPTM1L, WNT5B, FAM83H-AS1, VPS9D1-AS1, CASP4, CDH12, ACTL8, TRIM8, MIR938, MIR935, MNS16A, NETO2, LOC111365171, WDR48, MIR940, MIR889, TRMT9B, LOC110599580, NECTIN4, LOC110283621, MIR297, SNORD138, SLAIN2, KTN1-AS1, MIPEPP2, LOC100288966, CALCOCO1, DIP, ACAA1, AFA1, RAB1B, CCEPR, MIR888, QTRT1, LINC02418, LNPK, CHD8, ABCF1, ACACB, SEMA4G, MIR450B, METTL14, KIF18A, CASP10, MYH7B, TAOK1, EP400, LUADT1, ABO, ADCY3, FOXO6, DDHD1, NR4A1AS, LOC106128905, ZBTB2, ADCY1, UXT-AS1, MAP3K14-AS1, RNF146, MIR875, SPRY4, H3P13, GINS3, IATPR, RUNX1-IT1, PCAT6, LINC01234, ST3GAL6-AS1, DSCAM-AS1, LIFR-AS1, TCTN1, LINC00400, OCLN, SAP130, DDX11-AS1, LINC01354, CD58, NOC3L, GIHCG, DLEU7-AS1, FALEC, TTN-AS1, TTPAL, MELTF-AS1, MMP28, DHX58, CERS4, CCT6A, OVOL2, LINC01503, IQCJ-SCHIP1, FN3K, CA3-AS1, GAPLINC, SH3PXD2A-AS1, FOXD3-AS1, MAGI2-AS3, RIOX1, TINAGL1, DNAH17-AS1, LINC00649, STEAP4, LINC00958, CCT, LINC-ROR, BANCR, BEND5, IQCJ-SCHIP1-AS1, MCPH1, STARD13-AS, ADAMTS9-AS2, MAPKAP1, ITIH4-AS1, PSC, ACVRL1, POU6F2-AS2, RTN4R, PINK1, CD80, MIR4487, MRPL41, MIR4717, MIR4666A, MIR2467, HEIH, CD33, DCLRE1B, LINC00659, MIR4775, MIR4492, SIGLEC6, USP46, MIR378F, MIR4658, ACY1, BCL2L2-PABPN1, UBE2Z, HIF1A-AS1, MEG8, RNF26, DSCC1, MIR5191, ENTPD5, METTL16, CT47A12, SECISBP2, CUEDC2, HIF1A-AS2, VIM-AS1, SOX21-AS1, CAHM, RPL17-C18orf32, TMX2-CTNND1, CD27, CDH24, POC1B-GALNT4, ZSCAN18, MIR3150B, SLC39A8, E2F8, AK6, CDC25A, MIR6852, NCRUPAR, SEPTIN7, MIR6787, WWC2, RMI1, MIR663B, MIR6165, MYMX, SATB1-AS1, STN1, MIR4474, APOBEC3G, BRCA3, RINT1, ACHE, BOK-AS1, ZBED6, ADAM8, ADAM10, AFAP1, CDC25B, ZNF606, MIR1266, CHD9, MIR6868, HKDC1, CWH43, MIR1179, ASRGL1, MIR6778, MIR1236, SERPINH1, PTGES2, MIR6716, MIR8075, MIR1910, ZNF703, NTN4, FTX, MIR8064, MIR7702, CDC5L, ACR, CCNE1, MIR3679, ACOX1, ADA, CAMKMT, EHMT1, CCNC, PARVG, MIR3621, MIR3678, MIR642B, CD81, FKBP10, EZR-AS1, SHCBP1, CARF, MIR3940, LSINCT5, ACP5, OPN1MW3, ELMO3, NPY4R2, PRDM14, CASC9, MIR4282, MIR4261, SMAP1, HEATR6, MIR4319, KRIT1, MIR3191, SLC17A9, ELFN1-AS1, CNTD2, MIR514B, DOK3, CCNA2, GALNT11, XPNPEP3, CYBRD1, ACO2, MAP9, MIR4316, MIR4260, NEK11, CD2, SPDYA, OIP5-AS1, STK35, DACT3, ZNF582-AS1, AVPR2, CCBE1, NOTUM, ACF, C10orf143, KMT5A, ZNF785, TMED6, IL34, CMTM2, CMTM4, ZFP90, LINC00052, LINC00355, KRT80, CCL4L1, MUC15, XRRA1, DPP10-AS1, BEND4, PSMA8, FLT1P1, EIF5AL1, MIR100HG, GSEC, ZNF583, USP17L2, MIA3, ZFP57, STING1, POTEA, APP, ASPRV1, APOC3, RFPL4A, GPBAR1, ATP6V0A1, ARL6IP6, CYCSP51, CDKL4, ACTBL2, SATB2-AS1, ZNF829, ZDHHC8P1, APOC1, ATRX, GEN1, APOBEC1, LINC00654, RTN4RL2, ZACN, APOA4, BNIPL, DND1, PTPRQ, ST20, FENDRR, ANKLE1, ANXA13, AFAP1L1, PPARGC1B, IL31RA, AASDH, MIR133A2, MIR134, CPEB2, TMEM207, ANGPT1, BCL6, ANCR, AMT, RBM45, BIN1, AMELX, MIR153-1, AMCN, AMBP, ALX3, DIS3L2, MIR184, ZNF280A, TNFRSF17, PROKR2, SNHG11, NAXE, MIR188, GPR151, MIR125B1, MIR124-1, CASC15, ANXA11, ROMO1, LINC00668, LINC00909, ADAMTS14, ANXA7, MACROD2, CTCFL, GCNT7, ANXA6, S100A16, MUC17, ACTRT1, MUCL3, HOXB-AS3, GAB3, FOXR2, PASD1, TAF1L, MIRLET7D, VPS37A, MIRLET7I, MIR103A2, ANXA4, CLDN23, KLF14, BTLA, GADL1, MAP3K20-AS1, ATP6V1A, SGMS1, ENKUR, MRGPRX1, COPD, HIPK1, STEAP2, BEST4, SELENOH, TIGIT, ARRB1, TRIM23, TRIM65, SBF2-AS1, ARSB, FBXO45, RPL22L1, CRYGEP, ART1, TXLNA, DAND5, H19, ASAH1, B4GALNT3, IMMP1L, B3GNT6, PGAM5, EWSAT1, ARF6, UNC5B, LY6G6F, MCM9, RHOB, RHOC, GPRC6A, LNX2, IL27, TMEM9, FNDC5, CERS6, PRR15, VSTM2A, YTHDF3, THSD7A, LPCAT4, RHOH, HOXA11-AS, LINC00957, ARHGDIA, CT47A11, BCL6B, HNRNPUL2, JMJD1C, RNF152, HEPACAM, CBY2, ARHGAP30, TAB3, PGP, ADAMTS16, ASL, ZNF746, SLC35G1, SCARA5, NKX2-3, FIRRE, SBSPON, ATP2A3, EIF4E3, ESCO2, CDCA2, PEBP4, POTED, AGR3, ATP2B4, GRASP, SNAI3, CHSY3, TAS2R64P, ATP5F1B, SHISA3, PAQR3, ANO9, ATP5F1C, FFAR4, VSX2, JMJD8, ARMH1, FAM83H, DNAAF4, LINC00858, SLC9A9, CAVIN1, FAM27E5, AQP9, AQP6, DACT2, MIER3, SGMS2, ZFP82, ADGRA3, NWD1, DNAJB8, UBXN2A, FAM171B, LINC00996, OXER1, ATD, EPHA6, HFM1, SASS6, CITED4, CCDC66, RPL34-AS1, RGMB, ATF4, LINC00174, FSIP1, MIR190A, ALOX15B, SPANXA2, IL1F10, MIR545, TMEM25, RIOX2, TRIM52, MIR503HG, SFT2D3, MIR542, POLR2J4, SCARNA2, C19orf48, LINC00488, SNORA80E, MIR33B, CACNA1F, DDR1, MIR421, LNX1, MIR567, GPT2, MYO18B, PPP1R9B, HINT2, MIR568, ACCS, MIR572, SLC25A20, GLYR1, CA7, ATOH8, UTP4, MYLK2, TSPYL5, MIR484, TMEM75, ZIC5, ADRA1B, GAS8-AS1, NKD1, NR2F2-AS1, PHGR1, H3P16, EIF3J-DT, MNX1-AS1, LGALS12, SEMA3D, COL27A1, WFDC21P, TPTE2P1, CA4, LYPD8, NUDCD1, LINC00273, ADK, CT47A7, CA6, NME1-NME2, MASTL, MFSD14B, MIR584, HSPB6, AFAP1L2, KAT8, CALM3, CEP78, ADH7, USP44, CAMK2B, SSX2B, CT47A10, WDR54, CAMP, CT47A9, CT47A8, CT47A6, CAPG, CAPN1, CT47A5, CT47A4, CT47A3, CT47A2, CT47A1, DEFA1B, ANGPTL6, OPN1MW2, MEMO1P1, SETDB2, ATG10, CRISPLD2, MIR647, MIR646, PPP1R1B, MIR601, MIR585, MIR587, MAK16, MIR595, MRPL43, ACSS1, HOPX, ACRBP, CALB2, BRSK1, CALCA, RAB11FIP4, COG8, MIR637, MIEN1, PHF6, CALD1, CALM1, TCHP, FLYWCH1, MAF1, MIR612, MIR618, CALM2, LOXL4, RNASEH2C, SNORA21, MPPED2, MIR502, SSH2, AGAP3, AGRP, SNAP47, MIR95, BIK, PHACTR3, BATF2, ALPK2, LINC01555, ARHGEF25, PRKCQ-AS1, TRIM67, MAP1LC3C, FBXO32, SORCS1, VN1R17P, CSMD2, GPR166P, PKD1L2, AEBP1, MIR155HG, TIRAP, BMPR1B, MAL2, MIR323A, LACTB, TXNRD3, MIR30E, TADA1, MRGPRX3, C14orf28, TNFAIP8L1, MIR196A1, ZNF543, GJD3, SPNS2, BDKRB1, CCDC43, ALDOB, LRRC28, ALDH1A3, ALDH1B1, DEGS2, MIR24-1, MRGPRX4, MIR24-2, MIR26A1, SPIC, AHCY, FAM186A, BID, SLC36A4, GSTO2, MMP21, BORCS5, APLNR, GALNT15, MIR337, AP2A1, CDCA5, MIR519C, TIMD4, BTF3P11, MIR492, MIR493, MIR496, ISX, TRIM47, CCDC34, MIR193B, C1R, MIR520E, LINC00473, BMF, MTG1, IFT20, DCAF15, MIR519B, UNC5A, MIR520B, PHLDB2, MIR524, NAV3, MIR522, MIR500A, MIR501, SCIN, BTC, SPECC1, NACC1, TRIM72, MIR345, TP53RK, KRT71, MIR369, MIR370, SAT2, MIR374A, POTEE, SUMO1P3, EGLN3, EGLN2, BOK, CHAC2, MAFG-DT, ADRB3, HTRA3, MIR376A1, TTYH2, FOXP2, MIR4435-2HG, CKMT1A, MIR31HG, MIR448, NAPRT, UBE2Q2, MIR431, RPTOR, DGKB, MTUS1, SULT2A1, SUV39H1, TACR2, TACR1, TAF1, TAT, FPR2, TBL1X, TBX2, TBX5, FPR1, FOLR1, FMO5, FMO3, TDGF1P3, TFAP2C, FLT3LG, TGFB1I1, TGFB3, FLII, SUPT4H1, STYX, THBS4, STXBP1, SREBF2, SRPK1, SSBP1, ITPRID2, SSR1, ST8, ST14, FUCA1, STAT2, FTL, STATH, STAU1, SULT1E1, NEK4, STK4, CENPI, AURKC, STRN, STX1A, THBD, THM, FUT1, TPTE, TRAF5, CCT3, TRIO, TRIP6, TSC2, TTR, TULP3, FGR, TNFSF4, TNFRSF4, TYK2, TYRP1, UBE2I, UCN, UCP1, UGT2B15, UGT2B17, FGF12, UQCRB, TRC-GCA24-1, TPO, THOP1, TPM2, TIE1, FOXJ1, FOXL1, TLE1, TLE4, TLR1, FOXD4, TLR5, TM4SF4, CLEC3B, TNFRSF1A, TNNI3, TNNT1, TOP2B, FKBP3, TPBG, TPD52, TPH1, TPM1, SQLE, SPTBN1, RPS2, SERPINB3, SCN10A, SRL, CCL1, CXCL6, SDHB, SDHC, SDHD, SEMG1, GAS8, SFPQ, GAS6, GAS2, LRRC32, SRSF1, GALNT3, GALNT1, SH3GL3, SHC1, SI, SCN7A, ATXN7, ST3GAL4, GBP2, RPS6, RPS6KA3, GCNT1, RPS6KB2, RPS7, RPS27A, RRAS, RRBP1, RTN1, RYR3, S100A1, GCDH, S100A6, S100B, SAA1, SAA2, SAI1, SALL1, SBF1, SIAH1, ST8SIA1, SPTA1, SLC18A1, SLC25A1, GABBR1, GAB1, SLC22A2, SLIT1, SLPI, SMS, SNCB, SNRPA1, FUT7, SOS1, FUT5, SOX5, SOX10, SOX15, SOX12, FUT3, SPP2, FUT2, GABRA1, SLC14A1, SIPA1, SLC12A3, GALR1, SLC1A1, SLC1A2, SLC1A3, GALK1, GAGE7, SLC2A3, SLC3A2, SLC4A1, SLC5A2, GAD2, SLC6A2, SLC6A6, SLC6A8, SLC6A12, SLC7A1, SLC7A2, SLC8A1, SLC10A2, UQCRC1, FGF10, UQCRFS1, NCOA1, EIF3D, EIF3J, SLC4A4, ETV5, HYAL2, GALNT4, B4GALT3, B4GALT2, B3GALT4, SNX3, EED, ETS2, RNMT, GPAA1, HRK, TNFSF14, ADAM23, ADAM15, PABPC4, EIF3A, EYA1, TNFRSF14, AOC3, GAS7, DGKE, CST7, YBX3, BARX2, APOL1, F2R, F2, CDK10, DEGS1, DENR, MKNK1, CASK, AKR7A2, PLA2G4C, EYA2, JRK, RTCA, EIF4EBP3, CD164, TNFRSF11A, UROD, NR2F6, EPS8, TAF1C, TAF1B, TM4SF5, PKD2L1, SPAG9, ARTN, AIP, SYT7, CLDN12, CLDN8, SART1, USP14, USP2, FCGR2C, RGN, MTMR7, NMI, INA, NOL3, WASL, IL18R1, USP13, BANF1, CCN4, DLEU2, TSC22D1, KAT2B, AKAP4, ASAP2, ERG, IER3, SYNJ2, ERCC3, EIF2S2, CPNE3, MTMR3, PRPF4B, SGCE, RTL8C, WASF1, H3C7, MMP23A, MMP23B, ENC1, WNT6, XBP1P1, XDH, XK, GPC4, XPO1, FECH, FDXR, YWHAE, ZAP70, ZIC2, ZBTB16, FCGR2B, FBP1, ZYX, MEMO1, SCLC1, MAPKAPK3, BPTF, SLC39A7, WNT2B, FGB, TPST1, NSD2, USF2, USP1, UTRN, VASP, VCL, VCP, VDAC1, FGF8, VEGFB, VIL1, FGF3, VIPR1, VLDLR, TRPV1, VSNL1, VTN, WIPF1, EIF4H, LAT2, NTT, FAH, FZD3, ST7, F13A1, H3C1, H3C4, H3C3, H3C6, H3C11, H3C8, H3C12, H3C10, H3C2, PLA2G10, UXT, ANXA9, SNHG3, STK24, RASAL1, CUL4B, CUL3, CUL2, FZD8, EOMES, CDC45, GPR68, PSCA, FANCD2, PDHX, MFAP5, USP5, FXR1, YEATS4, FANCA, TCL1A, CDC7, SLC14A2, FABP5, MIA, TAM, PUDP, USP11, NAA10, FABP1, RPS4X, RPL27A, INTS2, MNAT1, MPG, MPL, HNRNPL, MPP3, CITED1, SLC29A2, HNMT, MSN, ONECUT1, MT1X, ND1, ND2, MTTP, TRNF, HMGB2, MUC7, MMUT, MXI1, GADD45B, CD200, MN1, MYH9, MMP19, HOXD@, MCM4, MCM7, MDFI, MEF2A, MEF2C, MEF2D, MFAP3, SCGB2A1, MGST1, MICB, MID1, HOXB@, HPCA, MLN, FOXO4, HOXA10, HOXA2, MMP15, MYH6, MYO1A, MARS1, HLA-DOA, MNX1, NFYB, NGFR, NINJ2, NIT1, NM, HK1, NME3, NME4, NNMT, HINT1, CNOT3, NPY, NRG1, NPAS2, NPTX1, NPTX2, NRDC, HELLS, NFIB, NFATC3, MYO5A, HLA-DQB1, MYO5B, MYO10, PPP1R12A, PPP1R12B, HNRNPM, NAP1L1, NAP1L2, NARS1, NUBP1, NCF4, NCK1, NDN, NDUFA4, NDUFB2, HLA-DRB4, SEPTIN2, NEDD8, NELL2, HLA-DRA, MAT1A, MARK1, RPL19, IRAK2, IRF5, IRF6, HYAL1, ITGA2B, ITGAM, ITGAX, ITGB6, ITGB8, ITK, ITPR3, IVD, HTN3, JAK3, HSPG2, KCNA3, KCNA5, HSP90AA2P, KCNMA1, KIF2A, IRF4, PDX1, KIR3DL2, INSRR, IGFBP1, IGFBP6, IGKC, RBPJ, IL2RG, ID4, MRPL58, IL7R, ICA1, IL10RA, IL12A, IL13RA2, IBSP, IARS1, IMPDH2, INCENP, INHBA, INPP1, INS, KIR2DL2, KLK1, MANBA, HSD17B4, HSD17B2, LLGL1, LMO1, LMO2, LPP, HSD11B2, HSD11B1, LRP5, LTA4H, BCAM, LYN, HRH2, MXD1, SMAD1, HRG, HPX, HOXD13, MAGEA3, MAL, LIPE, HSF4, KLRC1, LIF, KNG1, KIF11, KPNB1, KPNA3, IPO5, KRT5, KRT6B, KRT17, KRT18, LAMA2, LAMA3, HSPA1L, LAMP1, LBR, LCK, LECT2, DNAJA1, LGALS3BP, LGALS9, NUCB2, NUP98, OAS2, PRSS2, PSEN2, GNAT1, PYY, PSMC2, GML, PSMD7, PTGDR, PTGDS, PTGIS, PTHLH, PTMA, PTPN4, PTPN9, PTPN14, PTPRA, PTPRB, GLO1, PTPRH, PTPRO, PSD, PRS, PTS, GOT1, PPP2R2B, PPP2R5E, PPP3CA, PPP4C, PPY, NPY4R, PRCP, SRGN, PRKACB, FFAR1, GPR31, GPER1, PRLHR, MAPK7, GPR4, MAPK13, MAP2K3, DNAJC3, GP2, PTPRR, GPC3, OCA2, RGS2, RHO, RING1, RNASE1, BRD2, MSTN, RNPEP, ROBO2, RORB, RORC, OPN1MW, RPGR, RPA1, RPA3, GCNT2, RPL7A, RPL9, RPL11, RPL17, RPL18, RGS16, RGS1, PYCR1, RFX5, RAB5A, GIP, RAD51D, B4GALT1, RAN, RANBP2, RAP1B, RAP2B, RASA2, GFRA3, ARID4A, RBBP8, GFRA2, GFRA1, RENBP, GFAP, RFC3, RFC4, TRIM27, GRK6, PPP2CA, PPP1R8, PCK1, PCNT, PDC, PDE2A, PDE7A, PDGFA, ENPP1, GSTT2, PENK, PFDN1, PFDN4, ATP8B1, PFKFB3, PFN1, PFN2, CDK14, PGAM1, GSTA4, PHB, PHKB, GUSB, PCCB, PPP1R3C, PCBP1, HAS2, OGDH, HADHB, OLR1, OPRD1, SLC22A18, ORM2, H3-3B, OTC, CLDN11, H3-3A, P2RX5, H2AZ1, P2RY6, PA2G4, PRDX1, SERPINB2, GYPA, PAX3, PI3, SERPINA4, GSTA2, SERPINB9, SEPTIN4, GRB14, POLG, POLH, POLR2A, POLR2B, POLR2F, PON3, POU2F2, GPX3, PPAT, CTSA, PPIA, PPIB, PPL, PPM1A, GPT, PPP1CA, PPP1R3A, GRIN2B, PML, PMAIP1, PKLR, SERPINI1, PIGF, PIK3C3, GSPT1, PIK3R2, PIP, PKD1, PKD2, GRPR, PLXNA2, PDIA3, PLAGL1, PLAT, PLCD1, GRM2, FXYD1, PLOD2, PLSCR1, PRPF4, STX2, PDCD5, CXXC1, SOCS7, CTAG2, STOML2, KLK12, NOX4, PNPLA8, TAS2R16, TAS2R14, F11R, CPM, BHD, ASCC1, DERL2, ISOC1, DESI2, RPS27L, MEMO1, APIP, LACTB2, CR1, SOX8, ASB3, SPANXA1, CPS1-IT1, C1GALT1C1, TMEM208, BRD7, CTNNA3, RACGAP1, CARD10, PARVB, CYP2S1, ZDHHC1, GRHL1, CNOT7, EEF2K, HILPDA, NRBP1, CRAT, BICRA, ERO1A, TBX21, SAR1B, IRAK4, KLF15, SNX9, NAT8B, NELFCD, DTL, NCKIPSD, ANAPC11, RAB14, ACKR4, CNR2, CYRIB, CNN3, PLK3, RASD1, ZFR, ASB4, TPPP3, CPSF3, CNGB1, CYB5R1, RAB23, MAGEC2, AMOTL2, INSIG2, COMMD10, CKLF, CPA4, COL12A1, IGF2-AS, GLTP, PIPOX, KLF3, MAPKAPK5-AS1, GOLM1, CD320, BPIFA1, KCNK9, ARMCX1, TLR8, MEX3C, COL10A1, THEM6, UCHL5, COL5A2, ATAD2, MACROD1, SLC28A2, TMEM158, CTNNA1P1, ADGRA2, SH2B1, TSKU, TENM4, L3MBTL1, CSTB, RAB11FIP5, APPL1, CST4, CHTOP, CST3, LRIT1, LDLRAP1, CSRP1, CSNK2A1, INTS1, DGCR5, FBXL3, SAMHD1, TRIM58, PHGDH, LETMD1, CADM1, CTSZ, ARHGAP8, CTSS, TFIP11, FJX1, CBY1, CFAP45, CIZ1, GCA, LMOD1, TNFAIP8, ARIH1, MTO1, ASF1A, MOB4, PARM1, BRMS1, SUMF2, ARL5A, HIBCH, DBNL, PALD1, GLS2, SIGLEC9, IL17B, GPR162, SPINK4, RBMS3, CRX, TNRC6A, RPS6KA6, UBE2S, POLL, TMEM97, DESI1, MAT2B, SLCO3A1, IGHD1-14, DLL1, TRIB2, GIT1, NAAA, CRYGC, VPS33B, CACYBP, CSNK1D, MYCBP, HEYL, RGS17, MYEOV, CSN2, CKAP2, OR7C1, HAVCR1, SNORD44, SNORD33, RNU6-6P, HBP1, PABPC1, CSF3, LAT, PELP1, ANKRD1, NSG1, CAB39, UPB1, GHRL, OGDHL, CETN1, CES1, CENPF, ST6GALNAC1, FOXJ2, ARHGAP15, USE1, WSB2, GPRC5C, CENPE, THSD1, ACSS2, NXF2, MYDGF, PDGFC, PCDHGA7, PCDHG@, PCDHA@, PCDHB3, H2AJ, CETP, RNF20, ARFGAP1, LGR4, HES6, MACROH2A2, GPRC5D, KLK15, ENOSF1, CDV3, UBE2Q1, TENT5A, PRR5, THUMPD1, ZNF407, CHD7, HIF1AN, KDM4D, CEP72, CFL1, BTBD7, VPS35, GSDMC, PARD3, CNC2, ADAMTS9, CIAPIN1, TWSG1, KNL1, RAB25, APMAP, SCYL3, SLURP1, SMURF1, ZNFX1, VANGL2, LYRM2, SMAGP, ZNF304, GJD2, BIRC6, TENM2, PPM1H, CRACD, ARID1B, CDKN2D, CTNNBIP1, LTB4R2, CDS1, CTPS2, CEBPD, CHST7, DIABLO, KCNK12, AKIP1, JPH1, FMN2, CEBPA, TCIM, DPYSL5, NDUFA4L2, C1GALT1, EXOSC5, PMEPA1, DUSP22, EMSY, POGLUT1, CDC42SE2, TMEM176A, CHDH, CHD4, UGT2B28, RBM47, PCDH18, EXOSC4, TPP1, ROBO4, DLL4, CLIC1, EGLN1, UGT1A9, TMEM106B, CRLS1, CLC, RBFOX1, MPHOSPH8, EPDR1, FBLIM1, IL17RD, TRIM44, PPP1R12C, SMOX, CHPF2, VPS53, RNF216, ARID4B, LUC7L3, LTB4R, KDM3B, GALNT7, BCL11A, IL17D, MYO3A, SLC37A1, CCR4, CCR3, DCUN1D1, ERRFI1, TREM2, SOX18, CYTL1, WNT4, SSH1, MIEF1, RNF111, TRPM4, DCHS2, AHI1, CHRNA7, TMEM45A, FEZF2, KIF26B, AKIRIN2, PIWIL2, TRIM68, MTPAP, CEP55, RIF1, PBRM1, APPL2, CHIT1, MAP1S, DPPA4, SLC38A7, STEAP3, PACC1, IMP3, ANKRD40CL, CHUK, GID8, SLC66A1, NDE1, ERCC6L, CKMT1B, CDHR2, NXPE4, SYTL2, NSUN2, ALKBH5, CASZ1, CT55, CDKAL1, NSD3, FOCAD, TRMT10C, LPCAT2, CKB, SSH3, TIPIN, NTSR2, DAPK2, CYBA, TANK, TROAP, PIGK, DNAJB6, SMC4, EFNB1, DNM1L, NR1H3, GPC6, EEF2, ARPC4, ACTR2, KIF20A, HIPK3, LRPPRC, EDN3, ABI2, S1PR1, SLC25A13, TNK2, BCL2L10, CELSR3, TSHZ1, PTBP3, TRIM66, DDX46, KBTBD11, MFN2, MEGF6, DCLRE1A, WDR1, HS3ST2, USP3, SLC23A2, FGF19, TNFSF15, MED12, MED13, NUP153, CCS, FGFBP1, THOC1, RCE1, TXNDC9, PSME3, HYOU1, DUSP8, NDC80, WFDC2, IFITM3, OLFM1, ACAA2, HAX1, MERTK, SLC30A9, DSC1, TIMM44, SEC23A, CAP1, STK25, NCOA2, SEMA3C, FBLN5, CIB2, ARID3A, DDX17, TUBB4B, DUSP9, NME6, DVL1, ECM1, EIF1, FLOT1, CD96, NBR2, ECE1, RABEPK, SPRY1, EBF1, IRX5, RAMP3, ZMPSTE24, STUB1, STAG1, LILRB2, DLEU1, VPS26C, LANCL1, DYRK1A, MAGI2, FARP2, MFAP3L, SLC9A3R2, ENPEP, KIF3B, TM9SF2, SELENOF, TJP2, CYP7B1, MYLKP1, ELK4, ELK3, HOMER2, ELK1, HAND2, ELF3, ONECUT2, KIF23, TBX4, PAGE4, ADAMTS1, ELANE, TXNL1, RPL23, ZBTB24, DMTN, FIBP, LRRFIP1, MSC, RPS6KA5, CACNA2D2, AIMP1, MFHAS1, STK17B, STK17A, CYTH2, COPB2, GPR55, EPHA4, STOM, TRIP13, TRIP10, B4GALT6, B4GALT5, TCEAL1, GOSR1, BAG4, GMFG, EI24, MICAL2, ZNF516, VGLL4, BZW1, ULK2, EIF4A2, USP6NL, SEMA3E, EIF4A1, EIF2S3, SUSD6, PCLAF, EIF2S1, BMS1, TOMM20, SCRN1, TSC22D2, RB1CC1, EGR2, SH3PXD2A, IKBKE, CLCA2, KIF20B, TP53I3, IGDCC3, CHD1L, CCL4L2, BCAR1, GTF2IRD1, SOX13, RBM39, CREB5, SEC24C, PRDX6, EIF5, PITPNM1, RIN1, NCOR1, RNF7, EIF4EBP2, KLK4, DEAF1, IPO7, CASP14, CARD8, SEPHS1, CCT5, DDX1, GADD45A, AKR1C1, RAB21, PALLD, DAXX, PDS5B, NMNAT2, ZNF609, GGA2, SETD1B, MYCBP2, PHF8, KDM6B, EPB41L3, LRCH1, CIC, DDX6, RPH3A, SEPTIN6, DIS3, PDAP1, TUSC2, CBX3, U2AF2, EXOSC8, DEFB1, LAMB4, MRAS, DEFA6, RAB11FIP2, DEFA1, CPEB3, CHSY1, ADGRL1, NLRP1, ATG14, DDX11, MORC2, DHX9, DGKG, IFNGR2, NOP56, NOMO1, SF3B1, HEY1, TRAM1, ETHE1, SEC11A, PES1, CBX7, SPIDR, SRRM2, CYP3A7, SEC14L2, MAPK8IP2, DNPEP, PSD4, RASD2, TSPAN12, PIGN, GTPBP4, PADI4, RHOQ, ADNP, MESD, MAU2, RCOR1, DAB2, ARL6IP1, RRS1, SULF1, NUP210, DAB1, ARC, PACS2, BOP1, ATP11A, ANKRD12, CAMTA1, CYP51A1, ICOSLG, TRIM2, TTC28, LARP1, PPP1R13B, PHB2, COPE, PARK7, STAG2, RAI2, MASP2, TRDMT1, GIPC1, NES, KDM5B, SRSF10, IQGAP2, VAMP5, CCR9, DNM2, WASF3, UTP14A, DYNC1H1, PDE10A, CYP46A1, NMU, MRPS30, MALT1, SIX2, OGA, SLC6A14, FUT9, BATF, GLRX3, ARL6IP5, SLC19A2, CCT7, CCT2, TXNRD2, SMC2, ERN2, DPH1, SLCO1B1, PAICS, RBCK1, IVNS1ABP, DOK1, IGF2BP3, SPINT2, TNFSF13B, EBP, MTMR11, PAPOLA, MAGED2, FASTK, CD160, DIAPH1, KAT7, PLAAT3, HHLA2, DHODH, NUDT6, NUDT5, DGUOK, LZTS1, MAP4K1, CELF3, PTENP1, CFD, KLK8, TREX2, GALNT5, RASSF8, PDCD10, DIO2, BTN3A1, FGFR1OP, ATF7, ERP29, MLLT11, STIP1, EBNA1BP2, FERMT2, METAP2, SLC27A4, LILRB4, TENT4A, PRDM5, ADRM1, WWP1, DEPP1, TRIOBP, DIDO1, WDR5, ADAMTS13, ADAMTS8, H3P40
    • Familial Colorectal Cancer Gard
      In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes (mutations) in the APC , MYH , MLH1 , MSH2 , MSH6 , PMS2 , EPCAM , PTEN , STK11 , SMAD4 , BMPR1A , NTHL1 , POLE , and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable mutation in a gene known to cause a hereditary predisposition to colon cancer.
    • Colorectal Cancer Omim
      Genetic Heterogeneity of Colorectal Cancer Mutations in a single gene result in a marked predisposition to colorectal cancer in 2 distinct syndromes: familial adenomatous polyposis (FAP; 175100) and hereditary nonpolyposis colorectal cancer (HNPCC; see 120435). ... Epigenetic silencing of MSH2 results in a form of HNPCC (see HNPCC8, 613244). Other colorectal cancer syndromes include autosomal recessive adenomatous polyposis (608456), which is caused by mutations in the MUTYH gene (604933), and oligodontia-colorectal cancer syndrome (608615), which is caused by mutations in the AXIN2 gene (604025). ... Sivak et al. (1981) studied a kindred with the familial cancer syndrome in which every confirmed affected member had at least 1 primary carcinoma of the colon. ... The patients with cancer family syndrome were young, accounting for 29 to 39% of the patients under 50 years of age, and their tumors were located predominantly (65%) in the right hemicolon. ... This region includes the locus associated with hereditary mixed polyposis syndrome (HMPS; 601228) in families of Ashkenazi descent.
    • Colorectal Cancer Wikipedia
      The most common of these is hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome) which is present in about 3% of people with colorectal cancer. [18] Other syndromes that are strongly associated with colorectal cancer include Gardner syndrome and familial adenomatous polyposis (FAP). [30] For people with these syndromes, cancer almost always occurs and makes up 1% of the cancer cases. [31] A total proctocolectomy may be recommended for people with FAP as a preventative measure due to the high risk of malignancy. Colectomy, removal of the colon, may not suffice as a preventative measure because of the high risk of rectal cancer if the rectum remains. [32] The most common polyposis syndrome affecting the colon is serrated polyposis syndrome , [33] which is associated with a 25-40% risk of CRC. [34] Mutations in the pair of genes ( POLE and POLD1 ) have been associated with familial colon cancer. [35] Most deaths due to colon cancer are associated with metastatic disease. ... The common theme among these genes, across both tumor types, is their involvement in Wnt and TGF-β signaling pathways, which results in increased activity of MYC , a central player in colorectal cancer. [47] Mismatch repair (MMR) deficient tumours are characterized by a relatively high amount of poly-nucleotide tandem repeats. [48] This is caused by a deficiency in MMR proteins – which are typically caused by epigenetic silencing and or inherited mutations (e.g. Lynch syndrome ). [49] 15 to 18 percent of colorectal cancer tumours have MMR deficiencies, with 3 percent developing due to Lynch syndrome. [50] The role of the mismatch repair system is to protect the integrity of the genetic material within cells (i.e.: error detecting and correcting). [49] Consequently, a deficiency in MMR proteins may lead to an inability to detect and repair genetic damage, allowing for further cancer-causing mutations to occur and colorectal cancer to progress. [49] The polyp to cancer progression sequence is the classical model of colorectal cancer pathogenesis. [51] The polyp to cancer sequence describes the phases of transition from benign tumours into colorectal cancer over many years. [51] Central to the polyp to CRC sequence are gene mutations, epigenetic alterations and local inflammatory changes. [51] The polyp to CRC sequence can be used as an underlying framework to illustrate how specific molecular changes lead to various cancer subtypes. [51] Field defects [ edit ] Longitudinally opened freshly resected colon segment showing a cancer and four polyps. ... PMID 28922695 . ^ Juhn E, Khachemoune A (2010). "Gardner syndrome: skin manifestations, differential diagnosis and management". ... "Preventive surgery for colon cancer in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer syndrome"
  • Alcohol-Related Dementia Wikipedia
    Please consider expanding the lead to provide an accessible overview of all important aspects of the article. ( September 2014 ) Alcohol-related dementia ( ARD ) is a form of dementia caused by long-term, excessive consumption of alcoholic beverages , resulting in neurological damage and impaired cognitive function. [1] Contents 1 Terminology 2 Signs and symptoms 3 Pathophysiology 4 Diagnosis 4.1 Diagnostic criteria 5 Treatment 6 Epidemiology 7 Notable sufferers 8 References 9 External links Terminology [ edit ] Alcohol-related dementia is a broad term currently preferred among medical professionals. [2] Many experts use the terms alcohol (or alcoholic) dementia to describe a specific form of ARD, characterized by impaired executive function (planning, thinking, and judgment). [3] Another form of ARD is known as wet brain ( Wernicke–Korsakoff syndrome ), characterized by short term memory loss and thiamine (vitamin B1) deficiency. ... Other types of alcohol-related dementia such as Korsakoff's Syndrome cause the destruction of certain areas of the brain, where changes in memory, primarily a loss of short-term memory, [5] are the main symptom. ... External links [ edit ] Alcoholism & Substance Abuse: Alcohol Dementia Alzheimer's Society factsheet — What is Korsakoff's syndrome? Kato N (June 1991). "[Clinical concept of alcoholic dementia]". ... PMID 1892448 . v t e Psychoactive substance-related disorder General SID Substance intoxication / Drug overdose Substance-induced psychosis Withdrawal : Craving Neonatal withdrawal Post-acute-withdrawal syndrome (PAWS) SUD Substance abuse / Substance-related disorders Physical dependence / Psychological dependence / Substance dependence Combined substance use SUD Polysubstance dependence SID Combined drug intoxication (CDI) Alcohol SID Cardiovascular diseases Alcoholic cardiomyopathy Alcohol flush reaction (AFR) Gastrointestinal diseases Alcoholic liver disease (ALD): Alcoholic hepatitis Auto-brewery syndrome (ABS) Endocrine diseases Alcoholic ketoacidosis (AKA) Nervous system diseases Alcohol-related dementia (ARD) Alcohol intoxication Hangover Neurological disorders Alcoholic hallucinosis Alcoholic polyneuropathy Alcohol-related brain damage Alcohol withdrawal syndrome (AWS): Alcoholic hallucinosis Delirium tremens (DTs) Fetal alcohol spectrum disorder (FASD) Fetal alcohol syndrome (FAS) Korsakoff syndrome Positional alcohol nystagmus (PAN) Wernicke–Korsakoff syndrome (WKS, Korsakoff psychosis) Wernicke encephalopathy (WE) Respiratory tract diseases Alcohol-induced respiratory reactions Alcoholic lung disease SUD Alcoholism (alcohol use disorder (AUD)) Binge drinking Caffeine SID Caffeine-induced anxiety disorder Caffeine-induced sleep disorder Caffeinism SUD Caffeine dependence Cannabis SID Cannabis arteritis Cannabinoid hyperemesis syndrome (CHS) SUD Amotivational syndrome Cannabis use disorder (CUD) Synthetic cannabinoid use disorder Cocaine SID Cocaine intoxication Prenatal cocaine exposure (PCE) SUD Cocaine dependence Hallucinogen SID Acute intoxication from hallucinogens (bad trip) Hallucinogen persisting perception disorder (HPPD) Nicotine SID Nicotine poisoning Nicotine withdrawal SUD Nicotine dependence Opioids SID Opioid overdose SUD Opioid use disorder (OUD) Sedative / hypnotic SID Kindling (sedative–hypnotic withdrawal) benzodiazepine : SID Benzodiazepine overdose Benzodiazepine withdrawal SUD Benzodiazepine use disorder (BUD) Benzodiazepine dependence barbiturate : SID Barbiturate overdose SUD Barbiturate dependence Stimulants SID Stimulant psychosis amphetamine : SUD Amphetamine dependence Volatile solvent SID Sudden sniffing death syndrome (SSDS) Toluene toxicity SUD Inhalant abuse
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