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  • Acute Radiation Syndrome Wikipedia
    The loss of cells forming blood cells ( bone marrow ) and the cells in the digestive system ( microvilli , which form part of the wall of the intestines ) is fatal. [ citation needed ] Management [ edit ] Effect of medical care on acute radiation syndrome Treatment usually involves supportive care with possible symptomatic measures employed.
  • Haemophilia Wikipedia
    Her eldest son, Prince Alfonso of Spain, Prince of Asturias , died at the age of 31 from internal bleeding after his car hit a telephone booth. [54] Her youngest son, Infante Gonzalo , died at age 19 from abdominal bleeding following a minor car accident in which he and his sister hit a wall while avoiding a cyclist. Neither appeared injured or sought immediate medical care and Gonzalo died two days later from internal bleeding. [55] Treatment [ edit ] The method for the production of an antihaemophilic factor was discovered by Judith Graham Pool from Stanford University in 1964, [56] and approved for commercial use in 1971 in the United States under the name Cryoprecipitated AHF . [57] Together with the development of a system for transportation and storage of human plasma in 1965, this was the first time an efficient treatment for haemophilia became available. [58] Blood contamination [ edit ] Main article: Contaminated haemophilia blood products Ryan White was an American haemophiliac who became infected with HIV/AIDS through contaminated blood products .
    COX8A, F9, F8, TFPI, F2, ZAP70, AK3, PROC, F3, VWF, CCR5, F10, VIPR1, PROCR, TNF, F5, AAVS1, MTHFR, IFNA2, ADAMTS5, ABR, HAL, PRNP, PROS1, GH1, AMBP, IFNL3, CPB2, SLC4A1, HPSE2, TAL1, C4orf3, ASPG, PRDX2, THBD, IL33, CARD14, UPF3B, KRT20, NT5C2, LAP, HAP1, ARTN, SCLY, CD163, ABCB6, SERPINA10, SOST, FOXP3, ST14, NHS, SELP, GPT, AGRP, APC, APOH, BPI, C4BPA, CALR, MS4A1, CLTC, CSF2, DMD, DPP4, F7, G6PD, HLA-A, CCL3L1, HLA-B, HNF4A, ICAM1, IL2RA, IL6, ISG20, KRT7, LTF, MRC1, NFYA, TNFRSF11B, SERPINA5, SERPINE2, C20orf181
    • Hemophilia Orphanet
      Hemophilia is a genetic disorder characterized by spontaneous hemorrhage or prolonged bleeding due to factor VIII or IX deficiency. Epidemiology Annual incidence is estimated at 1/5,000 male births and the prevalence is estimated at 1/12,000. Clinical description Hemophilia primarily affects males, but female carriers of the disease-causing mutations may also manifest generally milder forms of the disease (symptomatic forms of hemophilia A and B in female carriers; see these terms). In general, onset of the bleeding anomalies occurs when affected infants start to learn to walk. The severity of the clinical manifestations depends on the extent of the coagulation factor deficiency.
    • Hemophilia GARD
      Hemophilia is a bleeding disorder that slows the blood clotting process. People with this disorder experience prolonged bleeding following an injury, surgery, or having a tooth pulled. In severe cases, heavy bleeding occurs after minor trauma or in the absence of injury. Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. The major types of this disorder are hemophilia A and hemophilia B . Although the two types have very similar signs and symptoms, they are caused by mutations in different genes.
    • Hemophilia Mayo Clinic
      Overview Hemophilia is a rare disorder in which the blood doesn't clot in the typical way because it doesn't have enough blood-clotting proteins (clotting factors). If you have hemophilia, you might bleed for a longer time after an injury than you would if your blood clotted properly. Small cuts usually aren't much of a problem. If you have a severe form of the condition, the main concern is bleeding inside your body, especially in your knees, ankles and elbows. Internal bleeding can damage your organs and tissues and be life-threatening. Hemophilia is almost always a genetic disorder. Treatment includes regular replacement of the specific clotting factor that is reduced.
  • Bulimia Nervosa Wikipedia
    This cycle may be repeated several times a week or, in more serious cases, several times a day [12] and may directly cause: Chronic gastric reflux after eating, secondary to vomiting [13] Dehydration and hypokalemia due to renal potassium loss in the presence of alkalosis and frequent vomiting [14] Electrolyte imbalance , which can lead to abnormal heart rhythms , cardiac arrest , and even death Esophagitis , or inflammation of the esophagus Mallory-Weiss tears Boerhaave syndrome , a rupture in the esophageal wall due to vomiting Oral trauma , in which repetitive insertion of fingers or other objects causes lacerations to the lining of the mouth or throat Russell's sign : calluses on knuckles and back of hands due to repeated trauma from incisors [15] [16] Perimolysis , or severe dental erosion of tooth enamel [17] Swollen salivary glands (for example, in the neck, under the jaw line) [17] [18] Gastroparesis , or delayed gastric emptying Constipation or diarrhea Tachycardia or palpitations Hypotension Peptic ulcers Infertility Constant weight fluctuations are common Elevated blood sugar , cholesterol , and amylase levels may occur Hypoglycemia may occur after vomiting These are some of the many signs that may indicate whether someone has bulimia nervosa: [19] A fixation on the number of calories consumed A fixation on and extreme consciousness of one's weight Low self-esteem and/or self-harming Suicidal tendencies An irregular menstrual cycle in women Regular trips to the bathroom, especially soon after eating Depression , anxiety disorders and sleep disorders Frequent occurrences involving consumption of abnormally large portions of food [20] The use of laxatives , diuretics , and diet pills Compulsive or excessive exercise Unhealthy/dry skin, hair, nails and lips Fatigue , or exhaustion As with many psychiatric illnesses, delusions can occur, in conjunction with other signs and symptoms, leaving the person with a false belief that is not ordinarily accepted by others. [21] People with bulimia nervosa may also exercise to a point that excludes other activities. [21] Interoceptive [ edit ] People with bulimia exhibit several interoceptive deficits, in which one experiences impairment in recognizing and discriminating between internal sensations, feelings, and emotions. [22] People with bulimia may also react negatively to somatic and affective states. [23] In relation to interoceptive sensitivity, hyposensitive individuals may not detect feelings of fullness in a normal and timely fashion, and therefore are prone to eating more calories. [22] Examining from a neural basis also connects elements of interoception and emotion; notable overlaps occur in the medial prefrontal cortex , anterior and posterior cingulate , and anterior insula cortices , which are linked to both interoception and emotional eating. [24] Related disorders [ edit ] People with bulimia are more likely than people without bulimia to have an affective disorder , such as depression or general anxiety disorder .
    SLC6A4, CHODL, NKAIN3, BDNF, LEP, OPN1SW, COMT, DRD4, HTR2A, TAL1, SCLY, KRT7, GHRL, HTR2C, MC4R, MCL1, PYY, NR3C1, SLC6A3, HTR1B, BED, ADIPOQ, DRD2, GHSR, GCG, FAAH, DST, CNR1, GLP1R, DPP4, CLOCK, ZGLP1, WASF3, CIT, TBC1D9, OR4G1P, OR2AG1, MBOAT4, CTNNBIP1, GGCT, FTO, LINC00880, EHMT1, NT5C1B, SYTL5, HTR3B, ATP8A2, AGRP, PEA15, MMP9, CCND1, ESR1, ESR2, GH1, GPT, HTR1A, HTR3A, IGF1, IGF2, NTRK2, ST8SIA4, OCA2, OXTR, ALDH1A1, BRD2, SHBG, SLC2A1, SNCA, SULT1A1, TPH1, ABCB1
    • Bulimia Nervosa Mayo Clinic
      Overview Bulimia (boo-LEE-me-uh) nervosa, commonly called bulimia, is a serious, potentially life-threatening eating disorder. People with bulimia may secretly binge — eating large amounts of food with a loss of control over the eating — and then purge, trying to get rid of the extra calories in an unhealthy way. To get rid of calories and prevent weight gain, people with bulimia may use different methods. For example, you may regularly self-induce vomiting or misuse laxatives, weight-loss supplements, diuretics or enemas after bingeing. Or you may use other ways to rid yourself of calories and prevent weight gain, such as fasting, strict dieting or excessive exercise.
  • Air Embolism Wikipedia
    The cavitation may be prevented from spreading by the narrow pores in the walls between vessel elements . The plant xylem sap may be able to detour around the cavitation through interconnections.
  • Mucopolysaccharidosis Type Iva GeneReviews
    Restrictive lung disease results from a small thorax, chest wall anomalies, spine deformities, neuromuscular compromise from cervical myelopathy, and hepatomegaly causing upward displacement of the diaphragm [Walker et al 2003, Hendriksz et al 2013].
    GALNS, GLB1, TRAPPC2L, IDS, RPS27, MPEG1, IDUA, TTK, ARSB, OPRM1, SUMF1, ST3GAL1, ST3GAL2, ST3GAL4, NAGLU, LGSN, LPA, ELF3, APRT
    • Mucopolysaccharidosis Type Iv MedlinePlus
      Mucopolysaccharidosis type IV (MPS IV), also known as Morquio syndrome, is a progressive condition that mainly affects the skeleton. The rate at which symptoms worsen varies among affected individuals. The first signs and symptoms of MPS IV usually become apparent during early childhood. Affected individuals develop various skeletal abnormalities, including short stature, knock knees , and abnormalities of the ribs, chest, spine, hips, and wrists. People with MPS IV often have joints that are loose and very flexible (hypermobile), but they may also have restricted movement in certain joints. A characteristic feature of this condition is underdevelopment (hypoplasia) of a peg-like bone in the neck called the odontoid process.
    • Morquio Syndrome Wikipedia
      Morquio syndrome Other names Mucopolysaccharidosis IV , MPS IV , Morquio-Brailsford syndrome , or Morquio [1] Keratan sulfate builds up in the lysosomes of people with Morquio syndrome, leading to symptoms Specialty Endocrinology Complications Skeletal abnormalities, hearing loss, pulmonary failure, heart disease Usual onset Birth; condition usually becomes apparent between ages 1 and 3 Duration Lifelong Types Type A and Type B Causes Inherited deficiency of enzymes Treatment Elosulfase alfa (Vimizim) for Type A; no approved treatment for Type B Prognosis Reduced lifespan. Usually death occurs in 20s to 30s Frequency 1 in 200,000 to 1 in 300,000 Morquio syndrome , also known as Mucopolysaccharidosis Type IV (MPS IV) , is a rare metabolic disorder in which the body cannot process certain types of sugar molecules called glycosaminoglycans (AKA GAGs, or mucopolysaccharides). In Morquio syndrome, the specific GAG which builds up in the body is called keratan sulfate . This birth defect , which is autosomal recessive , is a type of lysosomal storage disorder . The buildup of GAGs in different parts of the body causes symptoms in many different organ systems. [2] : 544 In the US, the incidence rate for Morquio syndrome is estimated at between 1 in 200,000 and 1 in 300,000 live births. [1] [3] Contents 1 Signs and symptoms 2 Cause 3 Diagnosis 3.1 Classification 4 Treatment 5 Prognosis 6 History 7 See also 8 References 9 External links Signs and symptoms [ edit ] Corneal clouding in a 30-year-old male with MPS VI.
    • Mucopolysaccharidosis Type Iva GARD
      Mucopolysaccharidosis type IVA (MPS IVA, also called Morquio syndrome, type A) is a metabolic condition that primarily affects the skeleton. The severity, age of onset, and associated symptoms vary significantly from person to person and range from a severe and rapidly progressive, early-onset form to a slowly progressive, later-onset form. The severe form is usually diagnosed between ages 1 and 3, while the milder form may not become evident until late childhood or adolescence. Signs and symptoms include various skeletal abnormalities such as short stature, knock knees, pectus carinatum , and malformations of the spine, hips and wrists. Affected people may also experience involvement of other organ systems such as respiratory problems, valvular heart disease , hearing impairment, corneal clouding , dental abnormalities, hepatomegaly , and spinal cord compression.
  • Kabuki Syndrome 1 OMIM
    Mihci et al. (2002) described a 7-year-old boy with Kabuki syndrome whose head MRI showed migration defects, including periventricular nodular heterotopia present along the walls of both lateral ventricles and an underdeveloped corpus callosum.
    KMT2D, KDM6A, RAP1B, RAP1A, KMT2A, KMT2B, MKKS, MACROD2, ANOS1, HTC2, HNRNPK, MAPK1, MAP2K7, TUBA3D, CHD7, TERF2IP, FZR1, ANKRD11, RABGEF1, TNFRSF13B, ZFPM2, POGZ, KDM1A, SEPTIN9, GH1, MBD2, MYH6, POMC, XIST, UTY, EPHB2, TUBA3C, SOX3, SET, RBPJ, ITGB7, BRAF
    • Kabuki Syndrome GeneReviews
      Summary Clinical characteristics. Kabuki syndrome (KS) is characterized by typical facial features (long palpebral fissures with eversion of the lateral third of the lower eyelid; arched and broad eyebrows; short columella with depressed nasal tip; large, prominent, or cupped ears), minor skeletal anomalies, persistence of fetal fingertip pads, mild-to-moderate intellectual disability, and postnatal growth deficiency. Other findings may include: congenital heart defects, genitourinary anomalies, cleft lip and/or palate, gastrointestinal anomalies including anal atresia, ptosis and strabismus, and widely spaced teeth and hypodontia. Functional differences can include: increased susceptibility to infections and autoimmune disorders, seizures, endocrinologic abnormalities (including isolated premature thelarche in females), feeding problems, and hearing loss. Diagnosis/testing. The diagnosis of KS is established in a proband of any age with a history of infantile hypotonia, developmental delay, and/or intellectual disability AND one or both of the following: Typical dysmorphic features (long palpebral fissures with eversion of the lateral third of the lower eyelid, and ≥2 of the following: arched and broad eyebrows with the lateral third displaying notching or sparseness; short columella with depressed nasal tip; large, prominent, or cupped ears; persistent fingertip pads) A heterozygous pathogenic variant in KMT2D or a heterozygous or hemizygous pathogenic variant in KDM6A Management. Treatment of manifestations: Thickened feedings and positioning after meals to treat gastroesophageal reflux; gastrostomy tube placement if feeding difficulties are severe.
    • Kabuki Syndrome 2 OMIM
      A number sign (#) is used with this entry because of evidence that Kabuki syndrome-2 (KABUK2) is caused by mutation in the KDM6A gene (300128) on chromosome Xp11. Description Kabuki syndrome is a congenital mental retardation syndrome with additional features, including postnatal dwarfism, a peculiar facies characterized by long palpebral fissures with eversion of the lateral third of the lower eyelids (reminiscent of the make-up of actors of Kabuki, a Japanese traditional theatrical form), a broad and depressed nasal tip, large prominent earlobes, a cleft or high-arched palate, scoliosis, short fifth finger, persistence of fingerpads, radiographic abnormalities of the vertebrae, hands, and hip joints, and recurrent otitis media in infancy (Niikawa et al., 1981). For a discussion of genetic heterogeneity of Kabuki syndrome, see KABUK1 (147920). Clinical Features Lederer et al. (2012) studied 2 girls and a boy with Kabuki syndrome. The 2-year-old boy and 13-year-old girl had a typical Kabuki syndrome phenotype, including long palpebral fissures, lateral eversion of the lower eyelid, and moderate to severe intellectual disability; they also displayed long halluces.
    • Kabuki Syndrome Orphanet
      A rare multiple congenital anomalies/neurodevelopmental disorder characterized by five major features: intellectual disability (typically mild to moderate), visceral malformations (frequently congenital heart defects), persistence of fetal fingertip pads, post-natal short stature, skeletal anomalies (brachymesophalangy, brachydactyly V, spinal column abnormalities and fifth digit clinodactyly) and specific facial features (arched and broad eyebrows, long palpebral fissures, eversion of the lower eyelid, large prominent, cupped ears, depressed nasal tip and short columella). Various additional features are frequently observed. Epidemiology The prevalence of Kabuki syndrome (KS) is estimated at 1/32000 birth and seems a frequent etiology in malformed fetus. Clinical description Presentation is typically with neonatal/infantile hypotonia and feeding difficulties (affecting more than 70%). KS associates developmental delay and intellectual disability in 90% of patients. Intellectual disability is frequently mild to moderate; however, the spectrum ranges from normal intellect to severe disability.
    • Kabuki Syndrome Wikipedia
      Kabuki syndrome Other names Niikawa–Kuroki syndrome A child with kabuki syndrome displaying the “scrunchy face” Specialty Medical genetics Symptoms Vary widely among patients but may include: Long eyelashes, depressed nasal tip, atypical fingerprints, ear deformity (macrotia or microtia), hypotonia, joint hyperflexibility, ptosis, blue sclera, cafe au lait spot, GU anomalies (e.g. hypospadias or horseshoe kidney), gi anomalies (e.g. anal atresia or intestinal malformation), hearing loss, immune deficiencies (e.g. hypogammaglobinemia), feeding difficulty (infants), obesity (adulthood), short stature, poor sleep, hyperinsulinemia (hypoglycemia), epilepsy, cardiac defects (e.g. coarctation of the aorta), vertebral anamolies (e.g. butterfly vertebrae), sparse lateral eyelash, finger anomaly (e.g. short 5th finger), cleft palate, dental issues, precocious puberty, scoliosis, hip dysplasia Usual onset Conception Types Type 1 (KMT2D), type 2 (KDM6A); other rare mutations unrecognized for now Causes Loss-of-function mutations in KMT2D or KDM6A genes Diagnostic method Clinical findings; genetic testing Frequency 1 in 32,000 births Kabuki syndrome (also previously known as Kabuki-makeup syndrome (KMS) or Niikawa–Kuroki syndrome ) is a congenital disorder of genetic origin. [1] [2] It affects multiple parts of the body, with varying symptoms and severity, although the most common is the characteristic facial appearance. [3] It is quite rare, affecting roughly one in 32,000 births. [4] It was first identified and described in 1981 by two Japanese groups, led by scientists Norio Niikawa and Yoshikazu Kuroki. [5] It is named Kabuki syndrome because of the facial resemblance of affected individuals to stage makeup used in kabuki , a Japanese traditional theatrical form. [4] Contents 1 Signs and symptoms 2 Causes 3 Pathophysiology 4 Diagnosis 5 Screening 6 Management 7 Prognosis 8 Epidemiology 9 Research 10 History 11 Gallery 12 References 13 External links Signs and symptoms [ edit ] Child displaying typical facial phenotype of Kabuki syndrome Specific symptoms for Kabuki syndrome vary, with large differences between affected individuals. [3] Most people with Kabuki syndrome have distinctive facial features that include arched eyebrows, long eyelashes, elongated eyelids with lower lids that turn out, prominent ears, a flat tip of the nose and a downward slant to the mouth. [3] [4] Child displaying elongated eyelids typical of Kabuki syndrome Child displaying distinctive facial features of Kabuki syndrome Other common symptoms are skeletal abnormalities, short stature, heart defects, feeding difficulties and a failure to thrive, vision and hearing difficulties, weak muscle tone ( hypotonia ), small head size ( microcephaly ), and frequent infections. [3] Mild to moderate intellectual disability and mild to severe developmental delay are often associated with Kabuki syndrome. [3] [4] [6] Infants and young children often experience difficulties relating to hypotonia, feeding issues/failure to thrive, infections, surgical repair of heart and palate defects and developmental delays. [ citation needed ] Young children with Kabuki syndrome benefit from early intervention services. School age children tend to have fewer medical issues requiring hospitalization, though frequent infections, hearing loss and feeding issues occur. In addition, intellectual impairment, difficulty with visuospatial tasks and maintaining attention usually require an IEP (individualized education plan) if the child attends public school. Older children and adults report difficulties with anxiety. Endocrine abnormalities and immune system abnormalities such as ITP (idiopathic thrombocytopenia) and CVID (common variable immune deficiency) are medical issues that tend to present in older children, adolescents and adults. [7] Causes [ edit ] Kabuki syndrome is one of the Mendelian disorders of epigenetic machinery. [8] Most cases of Kabuki syndrome occur de novo , that is, the parents are unaffected and the gene was mutated early in embryological development . It is classified as a Mendelian disorder because individuals who have a de novo mutation in a specific gene pass the mutation to offspring according to the laws of Mendelian inheritance .
    • Kabuki Syndrome MedlinePlus
      Kabuki syndrome is a disorder that affects many parts of the body. It is characterized by distinctive facial features including arched eyebrows ; long eyelashes ; long openings of the eyelids (long palpebral fissures ) with the lower lids turned out (everted) at the outside edges; a flat, broadened tip of the nose ; and large protruding earlobes. The name of this disorder comes from the resemblance of its characteristic facial appearance to stage makeup used in traditional Japanese Kabuki theater. People with Kabuki syndrome have mild to severe developmental delay and intellectual disability. Affected individuals may also have seizures, an unusually small head size (microcephaly ), or weak muscle tone (hypotonia). Some have eye problems such as rapid, involuntary eye movements (nystagmus) or eyes that do not look in the same direction (strabismus).
    • Kabuki Syndrome GARD
      Kabuki syndrome is a rare disorder that affects multiple parts of the body. It is present from birth. Specific symptoms and severity can vary. Features often include a characteristic facial appearance; skeletal abnormalities; short stature; heart defects; and intellectual disability. Other signs and symptoms may include seizures, microcephaly, weak muscle tone (hypotonia), eye problems, cleft palate, and dental problems. A variety of other health problems may also occur. Kabuki syndrome is most often caused by a mutation in the KMT2D gene, and inherited in an autosomal dominant manner. Some cases are due to a mutation in the KDM6A gene and are inherited in an X-linked dominant manner.
  • Cardiovascular Disease Wikipedia
    In women, the increase continues sharply until age 60 to 65 years. [29] Aging is also associated with changes in the mechanical and structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance and may subsequently lead to coronary artery disease. [30] Sex See also: Cardiovascular disease in women Men are at greater risk of heart disease than pre-menopausal women. [25] [31] Once past menopause , it has been argued that a woman's risk is similar to a man's [31] although more recent data from the WHO and UN disputes this. [25] If a female has diabetes, she is more likely to develop heart disease than a male with diabetes. [32] Coronary heart diseases are 2 to 5 times more common among middle-aged men than women. [29] In a study done by the World Health Organization , sex contributes to approximately 40% of the variation in sex ratios of coronary heart disease mortality. [33] Another study reports similar results finding that sex differences explains nearly half the risk associated with cardiovascular diseases [29] One of the proposed explanations for sex differences in cardiovascular diseases is hormonal difference. [29] Among women, estrogen is the predominant sex hormone.
    NOS3, LPA, APOB, APOE, ADRB1, ICAM1, ALB, LPL, GH1, APOC3, MPO, MTHFR, NPPB, VWF, EDN1, VCAM1, PON1, ACE, CETP, PTGS2, CST3, CCL2, AGT, CRP, HP, CYP2C19, NPY, SELE, CBS, SORT1, PON2, GPX1, GRK2, GRK5, SLC12A2, TNNT2, AGER, HMGCR, CHDH, LDLR, FTO, PCSK9, VDR, ABCG8, FBN2, LIPC, SH2B3, CASZ1, CYP11B2, DNMT1, TNC, DBH, INSR, PRKAG2, ADH1B, MEPE, BACE1, SCAF1, GCKR, MYBPC3, FUT2, CDKAL1, WRN, NPC1, PLPP3, RORA, MRAS, NPR1, SLC7A1, MCF2L, GUCY1A1, COL4A1, SEPTIN9, TNFRSF11B, OPRL1, PLG, TANGO2, EBF1, GOLGA6A, PLA2G2A, PKHD1, AAGAB, IL1B, PIK3CG, ZNF831, SERPINE1, UPF3A, CELSR2, EPHX2, COPD, HNF1A-AS1, PAX2, NDUFAF6, ENPEP, OR10A4, EFCAB13, PRDM16, DPYSL2, HOXB-AS3, BAHCC1, LINC01122, PREX1, CYBA, LINC02245, RBP4, CASC15, REG1A, PTX3, REN, PLEKHG1, REXO1, LIN54, JPH2, RGL3, SAA1, LINC01344, IGF1, DPP4, DECR1, DPEP1, PPARA, PPARG, EBF2, DLG2, HS1BP3, PRKCE, TMBIM1, PTH, CCDC148, OLR1, DBP, THADA, ACE2, CPEB2, ABHD17C, THAP9, LCORL, ESR1, TIMD4, CADPS2, FGD5, PRDM6, GML, HMOX1, GLP1R, LINC01312, FREM1, ZFAND2A, CDCA5, IL6, LSP1, NAV1, DOCK7, UBASH3B, HOXB3, MBL2, ADO, LGALS3, LEP, HOXC4, APOA5, IL18, ARHGAP42, OR10AD1, HIVEP2, INPP5A, HGFAC, IL10, AGAP1, C1QTNF4, LCN2, PHF13, APCDD1L-DT, NLRP3, GTF2I, KNG1, KPNA4, SLC9B1, NR3C1, HOXB5, GCG, ESR2, HPR, FES, NFATC2, NFE2L2, CCDC170, BICC1, NMT1, DBH-AS1, SVEP1, FABP4, FGB, TTC41P, NPNT, F3, RNF214, F2, MECOM, EHMT1, ALG9, MYO9B, MXI1, KDM2B, ANO5, NAA38, NR3C2, MMP2, GABPA, TCHP, UNC13D, MMP9, DCUN1D5, ZCCHC7, TMEM72-AS1, NKAIN4, PDILT, NCALD, MXD3, CABCOCO1, APOLD1, DLEU7, CMIP, NFKBIA, ZDHHC18, ATXN2, SELENBP1, PKD2L1, PDYN-AS1, ATP2B1, RERE, S1PR2, SLC9A3R2, KL, ADIPOQ, DNAJC27-AS1, DDX23, MYEOV, FGF21, GDF15, ZGLP1, GOSR2, USP34, KANK2, PNKD, APOA1, AVP, ZPR1, CACNA1D, MACROD1, VPS51, PLCE1, HSD17B12, AXIN1, MAD1L1, ATL1, APOL1, RUVBL1, UNC5C, DELEC1, UBN1, BDNF, UHRF1, ALDH1A2, LINC00452, HNRNPFP1, HRCT1, APLN, HIPK2, GIT2, C22orf31, HOTTIP, CERT1, CCND2-AS1, CRTC1, ZNF268, PDE10A, ADM, ADK, PLCB1, UTS2, ADCY9, SWAP70, CLUAP1, SORCS3, NT5C2, HSF2BP, LINC02646, ABO, HIBADH, IL1RAPL1, ABCA1, SORBS1, AGTR1, ATG7, C5orf67, ANGPT2, LHFPL2, TSPOAP1-AS1, GLYAT, TARID, DLEU1, LINC02227, LINC01478, LIPC-AS1, AHSG, ALOX5, CFDP1, ZFPM2, C1QTNF7-AS1, ALDH2, LINC01169, LINC02576, SIRT1, FGF23, RPS6, CACNB2, CHI3L1, CD36, TNF, TLR4, CCHCR1, TGFB1, ARL15, TERF2, PLA2G7, PAQR5, PGPEP1, RNF43, TXNL4B, BANK1, MIR21, ZC3HC1, ARMC4, RCBTB1, SPP1, CLCN6, SOS2, TBC1D19, ABCF3, SOX6, SLC5A2, SHBG, SELP, RETN, C1GALT1, CD14, BCAS3, CCND2, SPTBN5, WNT2B, YES1, IRF1-AS1, PALM2AKAP2, WT1-AS, LIMA1, VEGFA, CAD, ANGPTL3, ADAMTS13, MGP, PGR-AS1, IL1A, HGF, ELN, APLNR, DSPP, COX2, FLNA, SMUG1, BMS1, IL6R, TCF7L2, ACACA, BGLAP, IL33, ADRB2, NOX4, PIK3CA, ACTB, CXCL12, SOST, MTCO2P12, SIRT3, CDKN2A, PIK3CB, NHS, TM6SF2, TNNI3, PIK3CD, CDKN2B-AS1, EDNRA, COMT, CX3CR1, RAPGEF5, ROS1, RARRES2, MOK, GPT, SIRT6, HSD11B1, PNPLA3, MIR155, S100A9, S100A12, ANPEP, AGTR2, ANGPTL4, LIPG, GIP, CD40LG, CTSS, F5, HFE, IMPACT, ATM, HIF1A, CXCL8, SCARB1, MIR146A, GNB3, CYP19A1, ADA, PDE5A, THBD, TXN, ANGPTL2, LOX, CHGA, PPIA, ATP6AP2, CP, PLA2G1B, SAA2, UCP2, UMOD, S100A8, SCN5A, SLC33A1, CXCR4, SLC6A4, MTTP, WASF1, UGT1A1, SELENOS, CXCR6, ABCG1, CLOCK, NOS1, MMP1, RMC1, PROS1, THBS1, MMP8, PTGS1, LEPR, NPPC, PTPN1, MMP12, TNFSF11, NTS, KDR, VKORC1, KCNQ1, PPIG, SOD1, PLA2G6, KLF2, STAT3, ANGPT1, ADRA2B, CIMT, FABP3, CD34, MIR126, G6PD, MIR210, AHR, CAV1, NQO1, FBN1, GSTK1, C20orf181, KIF6, CCR5, CFH, SLCO6A1, BTF3P11, MIR499A, CDKN2B, ELANE, ENG, EPO, KLK3, ARSA, HLA-DRB1, HSPD1, FSHMD1A, SOD3, SOD2, COL4A2, SSTR4, TM7SF2, MIR221, TH, MIR34A, MFAP1, FSD1L, FSD1, ACCS, USF1, CAT, CASP1, MAS1, CA2, PLA2G10, BRS3, BRCA2, MIR145, ACKR3, FOXO3, FABP2, PAPPA, SERPINF1, C1QTNF9, DHX40, PLAG1, AGXT2, P2RY12, PPARD, F7, NPR3, F11, MAPK1, NPPA, MAPK3, SHMT1, CYP7A1, CXCL16, NOS2, TRIB3, PTGIS, RAPSN, CTH, CRYGD, GJA1, CCL5, APOM, SELENOP, ACSS2, BRCA1, TYRP1, PSAT1, GPR42, TMEM54, LPAR2, PARP1, POLDIP2, ADRA1A, APRT, NPEPPS, LBP, IRS1, TBPL1, WASF2, PADI4, IL17A, ALOX5AP, KCNH2, CACUL1, ABCC6, PPARGC1A, PLA2G15, HPGDS, F2RL3, TNFRSF11A, DNER, ITGB3, HSPB2, NR1I2, HSPB1, CAPN10, ABCB6, HSPB3, GPER1, B2M, CYP2J2, RFC1, ROCK1, PART1, NAMPT, RENBP, CYBB, MIR122, CTSK, GDF11, AMPD1, TRIB1, SLC35A1, MALAT1, DDAH2, PDE4A, FSTL1, PGF, ABCB1, MMRN1, CST12P, ADD1, PLAT, DUSP1, PLTP, ADH1C, POMC, ADRB3, AHSA1, PRKAA1, CBSL, PEAR1, ABCG5, AKR1B1, NOD1, BRD4, S100A1, CPB2, MAPK14, TP53, MIR22, NOX1, TFPI, CCR2, MIR33A, IL32, IL1RL1, TLR2, TNFRSF1A, TNFRSF1B, IL23A, MIR208A, VCL, CALR, MGAM, CALCR, SLC25A20, AIMP2, GP6, C4B, TSPO, KLF15, GRAP2, FADS2, RNF19A, SI, MIR132, CRK, CRH, KEAP1, PDGFC, APOA4, TNFSF10, COX8A, MIR143, HTR2A, SLC2A1, ST2, SLC2A2, SLC2A4, GAL3ST1, ROCK2, CNR1, SLC17A5, HAVCR1, CLU, NTN1, ARG1, SERPINA5, ANGPTL8, FABP1, INSRR, MSRA, GSTT1, CD180, FN1, EPRS1, FOXO1, FLAD1, BPIFB4, ADM2, PHACTR1, GLUL, FCGR3A, IGFBP3, HSPA5, ADIPOR2, IGFBP1, MMP7, LTA, SPX, IL4, FGG, MUSK, MME, HSPA1A, LCAT, FCGR3B, GOT2, MTR, HABP2, MEG3, WDR1, CNR2, NR1H4, DIANPH, SOAT1, GPR35, MRGPRX3, CUBN, LYPD4, APOA2, TRIM21, MTOR, APOC1, APOC2, LTC4S, ABCC9, SLC22A3, C3, CYP4F3, SLC2A9, HLA-B, INS, ANK2, CXCL5, DDAH1, ANXA1, SELPLG, NRG1, TUBB1, SFRP5, SFTPD, FZD4, COX1, FLNC, FLT1, SLC6A2, CHRNA5, CISD1, SLC6A8, MIR150, MRGPRX4, FMO3, HLP, MIR208B, APP, GHS, IL37, CD47, XPR1, CD44, MAP3K5, GDF2, CD38, GSTM1, CRISP2, TRAF1, HSP90B2P, RHOA, TTR, RNU1-1, MEFV, MEF2A, PDE3A, MDM2, SIRT7, GCH1, VASP, CD5L, ANKRD1, TNFSF12-TNFSF13, VN1R17P, GPR166P, ASIC3, BEST1, MET, CD69, MAOA, HDL3, MIR214, JAK3, TAC1, IL15, MIR222, MIR223, MIR28, TAT, PCSK7, HNF1A, MIR29A, OXER1, GPBAR1, TET2, GAS6, PTPN22, KMT2A, BAG3, CALCA, CDH13, GPX3, PXDN, KCNJ5, GATA4, HOPX, TREM1, HFM, CR1, LTA4H, IL11, IGF2BP2, HSPA4, PON3, IGF2, MRGPRX1, IRS2, PPBP, C1QL1, ETV3, PTPA, MLC1, PRKAA2, PRKAB1, NPR2, PRKCD, MIA3, BID, NOD2, NOTCH3, AOC3, DAPK3, LGR6, PROC, NEDD4L, CYP11B1, PSEN1, NOTCH1, FBLN1, ARSI, PER2, ADAM10, WNK1, LOC110806262, ENPP1, HTR2C, PDZK1, PECAM1, PAH, PF4, P2RX7, RIPK2, SERPINA1, EGR1, ACLY, PITX2, OGN, TNFSF12, RAPGEF4, PLA2G4A, EPOR, PLAU, DKK1, MYOCD, PINK1, IFNG, PLN, ERG, KCNIP3, HAMP, ARMS2, TRPV1, S100B, KLF14, KLF5, RLN2, CCN2, CTF1, MBL3P, DEGS1, POSTN, ALOX12, UCMA, NBN, FBLN5, CRYZ, BSG, IL6ST, MIRLET7G, MIR106A, RPS6KA1, RAPGEF3, PNPLA2, AKR1A1, FADS1, FGA, RGS2, GIPR, IL1RN, LPAR3, PTGIR, GRK3, HMGB1, GPR151, CYP3A4, GPRC6A, CYP2D6, LRP5, ZC3H12A, OGT, CYP2C9, SCD, CYP1B1, CYP1A2, SAT1, FGFR4, NGF, AKT1, ZNF385B, SETD2, NAAA, AGO2, MYLIP, BRD7, PPM1K, SLC27A6, MIR486-1, BTLA, PDCD4, PDLIM3, GGTLC5P, GGT2, SFTPA1, GGTLC3, NCF1, MAT2B, TOR2A, MIR652, CYTOR, SERP1, COA3, UCA1, REM1, MIR642A, MUC16, POTEF, TMEM43, PLB1, TARDBP, CAMTA1, SZT2, PPARGC1B, TP53COR1, PROKR2, TPSD1, TRS-AGA2-3, SFTPA2, FUNDC1, ACTRT1, HIF1A-AS1, MIR499B, TSPAN15, ARL2BP, APOA1-AS, PHLPP1, RBM45, ARL6IP1, LPIN1, ERICD, CNOT1, RN7SL263P, SIRT1-AS, SIRT2, ATF6, LOC107987479, GNPDA2, LOC110599569, CARD8, ADGRL1, TDGF1P6, TTC7B, NRG4, DAPK2, ATRNL1, TUBA3D, AKR1B1P3, TXNRD3, COMMD7, TIRAP, GGTLC4P, CYGB, FBXO8, PSS, OSBPL11, C1QTNF3, TES, CILP2, C1QTNF6, LRIG1, LINC01672, OMA1, SLC22A12, BEAN1, POU2F3, TXN2, PRDX5, SAMM50, GCA, CERNA1, ZNF318, MTCH2, SENP1, BRD7P3, AAA1, MIR483, MIR98, NPS, SLC44A2, LPAL2, SMYD2, MIR130B, PPP1R2C, PDGFD, MIR125A, PDXP, TBX20, MIRLET7C, C1QTNF12, ASRGL1, ARFGEF3, JPH3, AS3MT, AHRR, ZBTB12, SEMA6A, LINC01194, MIR139, SPIRE1, SPHK2, MIR142, ENAH, KDM3A, MIR17, CENPJ, MIR148A, ARID5B, USE1, SESN2, GPRC5C, MIR144, STOX1, APOL6, TBATA, ZEB1-AS1, MYDGF, COL18A1, CLDND1, JCAD, CHD8, CHD7, BTBD8, TAS2R50, BCL11B, IS1, ACD, TNFAIP8L2, HCAR2, GPIHBP1, BPIFA4P, KCTD1, SERPINA13P, UBE2Z, PAGR1, NOX5, KCTD15, SLC22A24, MAPKAP1, MBOAT7, NEAT1, NIBAN2, GORASP1, ECHDC3, NANOS3, STN1, TNRC6C, SPTBN4, IL27, PRM3, FNDC5, TRPV4, HEATR6, SLC27A1, ENHO, FRMD3, FBRS, AGBL2, HHIP, TICAM2, HCP5B, HSD17B13, ATF7IP, PLXNA3, UBIAD1, ANGPT4, MIR378A, UCN2, CRIM1, KLF3, CD320, TLR8, TNFRSF12A, KRT90P, MIR342, MIR99B, WNT16, MIR331, TRPV2, SYNPO2, PCYOX1, DCDC2, ADTRP, MIR17HG, HSPA14, INSIG2, ABHD5, ADIPOR1, DAB2IP, DSE, CERS2, CALML6, RHOD, VSX1, MIR451A, MIR429, BDNF-AS, IL22, MIR383, PAQR7, IRX4, FOXP3, MLXIPL, MIR382, TNNI3K, CNDP1, MIR99A, SLC35E3, PPP6R3, RLS1, MIR216A, RMST, ATG16L1, PRMT6, NADSYN1, SPRED2, NAT10, MIR200B, SCLY, MIR197, ZBTB7C, PRSS55, MGLL, MIR188, MIR185, KIAA1109, GPRC5D, TRPM7, DYM, TRPM4, MARCHF5, MED15, LSR, GHRL, PTCRA, MIR96, SPZ1, ARID4B, ZGPAT, INPP5K, IL17D, TPCN1, FAM3B, HHIPL1, MIR30C2, UGT1A6, MIR30C1, MIR29C, COG2, A2M, NRM, GCLC, GRIA1, FFAR2, GPR15, UTS2R, CXCR3, GP5, GJA5, CXCL2, GJA4, GGT1, GDF10, MSTN, GCK, GC, GRN, GSN, EDNRB, HLA-DQA1, HSD11B2, HRH1, HPD, HOXD13, HNRNPA1, HNF4A, HLA-DMA, HBA1, HLA-C, HDLBP, HDAC2, HTT, HCRTR2, HCRT, GAP43, GALR1, GAD1, ETV2, FAAH, F13A1, F12, F9, F8, F2RL1, FBL, ACKR1, ERCC3, EPHX1, EPHA1, SLC29A1, EGFR, EFNB2, FANCD2, FAT1, FCGR2A, FDFT1, FDXR, FER, FGF2, FHL1, FHL2, VEGFD, FOXC2, FOXM1, FLNB, FLT3LG, FOLH1, FOS, FOSB, HSF1, HSF4, HSPA1B, MC3R, MFAP4, MEN1, MAP3K3, MEIS1, DNAJB9, ADAM11, MBP, LRP1, MB, MAT1A, MAPT, MAP4, EPCAM, LRPAP1, MIF, FOXO4, MMP3, MMP11, MMP13, MMP14, MPI, MPZ, MRC1, MSR1, MST1, MT1A, MT1B, CYTB, ND5, RNR2, MTRR, LRP6, LOXL1, HSPA2, IL5, ITGB4, ITGB2, IRF6, IRF5, CXCL10, TNFRSF9, IL4R, LNPEP, IL1R1, IGFBP4, IGFBP2, IGFALS, IDH2, IDE, ITPA, JAK2, JUN, JUNB, JUND, KCNE1, KCNJ11, KCNMA1, KCNN4, KLKB1, KRT7, LGALS1, LGALS2, LGALS3BP, LIPA, LIPE, LMNA, EEF1A1, EDN2, TRNL2, ATP4A, CCND1, BCHE, BBS4, BBS1, ATP5PF, ALDH7A1, ATP12A, BCL2L1, ATHS, ATF3, ARSD, ARNTL, ARG2, AR, BCL2A1, BCL3, LPAR1, BMPR1A, CAV3, CASR, CAPN1, CAMP, CAPN5, SERPING1, BMP2, TNFRSF17, BHMT, CEACAM1, BGN, CFB, BDKRB2, BCR, AQP7, AQP4, AQP1, ACYP2, AKT2, NR0B1, AGRP, ACAN, ADRA2A, ADAM8, ACVRL1, APOH, ACP1, ACHE, ACAT1, ABL1, ABCA2, AAVS1, ALCAM, ALDH9A1, ALOX15, ALPL, ALPP, AMBP, AMCN, AMD1, AMD1P2, AMH, ANG, ANXA5, ANXA7, AOC2, APCS, APEX1, BIRC3, RUNX1, RUNX3, SERPINH1, NKX2-5, CYP2B6, CYP1A1, CTSL, CTSD, CTRL, CTNNB1, CSTB, CREM, VCAN, CSN3, CSN2, CSF3, CSF1, CRY1, CYP2C18, CYP3A5, CYP27A1, DACH1, DCN, DDT, DES, DHCR7, DMBT1, DMD, TRDMT1, DNMT3A, DRD4, TSC22D3, HBEGF, ECE1, TYMP, CRMP1, CPOX, CD6, CDK8, CENPC, CEBPD, CEBPB, CEBPA, CEACAM5, CDK9, CDC42, CORT, CDC25C, CD74, CD40, CD86, CD28, CD19, CES1, CETN1, CGA, CHGB, CHM, CISH, CLCN3, CLCN7, LTB4R, CMM, COL5A1, COL5A2, COL9A1, COL9A2, COL9A3, COMP, KLF6, TRNL1, MUC1, PACSIN2, MBTPS1, TMEM11, IQGAP1, IL18R1, IL18RAP, CREG1, TNFRSF10B, TNFRSF25, GGH, GALNT4, BECN1, VAMP8, SOCS1, TP63, DENR, SOCS2, CCN6, TNFAIP6, ARTN, DCLK1, OSMR, HGS, ARHGEF1, ANGPTL1, AIP, CCRL2, HDAC3, KALRN, TIMELESS, AP1G2, SPHK1, VNN1, ALKBH1, CYP4F2, RGS5, SOAT2, VDAC1, YWHAZ, XDH, WNT5A, NSD2, VTN, VHL, UTRN, NR0B2, UCP1, UCN, TYMS, TXNRD1, TNFSF4, TRPC1, LRP8, BSND, LEPQTL1, LAG5, TFEB, TFPI2, ARHGEF5, FOSL1, AAAS, HMGA2, AKAP1, TAM, ESS2, KDM5D, DYSF, ACOX2, BRAP, MSC, GPR55, CD163, PROCR, GJB6, NES, TRAF3IP2, OGA, CORIN, TXNIP, CIB1, FSTL3, STK25, FST, PPIH, IFI30, SPON2, APBB3, CCL27, HPSE, PROKR1, GADD45G, COPS8, PRDX3, GPR75, STIP1, KCNQ1OT1, KLK11, ESM1, WDR5, ADAMTS5, WDHD1, SLC2A6, NISCH, WIF1, EFS, SPRY2, SLIT2, H6PD, ELMO1, PCLAF, RIPOR2, NOS1AP, PPP6R2, NUP155, GMFG, SPRY1, ADAMTS1, CHST3, MAP4K4, AIM2, MED23, COX5A, MAGI2, RNF10, MFN2, SLC23A2, SCO2, NAALAD2, SRA1, PDCD6IP, SLC17A4, DNM1L, PTPRU, GPC6, PPIF, LRPPRC, G3BP1, ABI2, PRG4, TRAF6, TLR1, MYH7, PRKD1, EIF2AK2, MAPK10, MAPK9, MAPK8, MAPK7, PRKG1, PRKCA, MASP1, PRKAR2A, PRKAR1A, PREP, PPID, PODXL, SEPTIN4, PRL, RELN, TIMP4, RAC1, RNASE3, RNASE1, RIEG2, RELA, RASGRF1, RARA, PTPN11, HTRA1, PTGER3, PTGER2, PTGDS, TAS2R38, PTAFR, PSMA6, PMP22, PMM2, PLK1, NOTCH4, OPA1, OGG1, NR4A2, NUCB2, NT5E, NPY1R, NNMT, PLIN1, NME1, NM, NFKB1, NF1, MYOD1, MYLK, OPRK1, SLC22A18, OSM, OXA1L, PAEP, SERPINB2, PC, PCBP1, PDE4D, PDGFB, ENPP3, PDR, PEPD, SLC25A3, PIN1, PIP, PLAUR, BRD2, RNU1-4, ROBO1, STAT4, ADAM17, SYT1, ABCC8, SULT1A1, STK11, SULT1E1, SERPINA3, SMS, STAT2, ST13, SSB, SRM, SOS1, SORL1, TACR1, TAGLN, TAL1, TBXAS1, TRA, TERC, TERF1, TERT, TFR2, TFRC, TGFBR1, TGFBR2, THBS2, THBS4, THPO, TIAM1, TIMP1, SNAP25, SMPD1, RPE, SCN2A, CCL20, CCL7, CCL3, SCT, SCN10A, SCN8A, ACSM3, SMO, SAG, RYR3, RYR2, RYR1, RPS20, RPS6KB1, CCL21, CCL22, CCL23, SFRP1, SHC1, SLC1A5, SLC5A1, SLC6A7, SLC8A1, SLC9A1, SLC10A1, SLC12A3, SLC19A1, SLC20A2, SLC22A2, SLPI, SMARCA4, LOC113664106
  • Visceral Leishmaniasis Wikipedia
    The sandfly species Lutzomyia longipalpis is the primary vector of this disease. [9] The larvae grow in warm, moist organic matter (such as old trees, house walls, or waste) making them hard to eradicate. [ citation needed ] Visceral Leishmaniasis/kala-azar samples from India revealed the presence of not only the primary causative protozoan parasite, i.e.
    TNF, IL10, IFNG, SLC11A1, IL1B, HLA-DRB1, IL6, HMOX1, CSF2, HLA-DQA1, CXCL8, IL10RA, CRP, IL4, HSPA4, TLR4, MBL2, FOXP3, HIF1A, SLC6A3, TLR2, LEP, IL17A, IL9, IL2, TLR9, P4HB, CYTB, IL15, LMLN, IL12RB1, DDX56, IGF1, CCR7, CD69, MAPK1, ODC1, DLL1, RAB6A, MPL, NOS2, IL4R, CD58, IFNGR1, RCE1, NUP93, NPEPPS, PDCD1LG2, RABEPK, IL32, UNC13D, CPQ, ZNRD2, CXCL13, DCTN6, TICAM2, LANCL1, SOCS1, ARHGEF2, TGFB1, SMPD2, SPAG1, ST2, STAT3, TARS1, TBP, TGFBI, PKD2L1, H3P23, TP53, TNFSF4, TP63, POP1, HSPB3, TNFSF13B, SMUG1, EBNA1BP2, MON2, MIR155, CDK12, TREM1, ZNF469, FBLIM1, GOPC, HAMP, MIR122, CXCL16, AGMO, ASPG, NOD2, FAM120B, POPDC3, MLST8, PDIA2, TARS2, TMED7-TICAM2, IL33, IL23A, CLEC4D, DICER1, SIRT1, PIGZ, SLC17A5, CD274, RBM45, PADI1, PYDC5, NELFCD, PSAT1, TARS3, NLRP3, SMARCB1, MTCO2P12, TMED7, PRRT2, ARMH1, ACTB, SLAMF1, SGTA, F5, FCN2, FH, FOXO1, G6PD, GABPA, HLA-C, HLA-G, HSPA1A, HSPA1B, HSPA2, HSP90AA1, IFI27, IFNA1, IFNA13, IL2RA, IL2RB, ELF2, EEF1B2, DUSP4, CD14, AHCY, APOA1, KLK3, AQP1, BCS1L, CASP3, CD1A, CD34, DPP4, CD40, CD40LG, CPB1, CTLA4, CTSB, CYP51A1, DDT, IL5, CXCR1, CXCR2, PPARA, NCAM1, NFE2L2, NOTCH3, NRAS, ADA, PHB, PLAG1, PRKCA, COX2, PRKCB, MAPK10, PROS1, PSMD7, PSMD9, RNASE2, CCL2, MYD88, MMP9, IL13, RPSA, IL18, CXCL10, INPP5D, IRF1, IRF5, ISG20, ITGB2, LCK, MMP2, LECT2, LGALS1, LPL, LTA, MATK, MIF, CXCL9, H3P28
  • Cirrhosis Wikipedia
    Blood from the portal venous system may be shunted through the periumbilical veins and ultimately to the abdominal wall veins, manifesting as a pattern that may resemble the head of Medusa . [14] Cruveilhier-Baumgarten bruit is a venous hum heard in the epigastric region (on examination by stethoscope) due to collateral connections forming between the portal system and the periumbilical veins as a result of portal hypertension.
    NFE2L2, AGT, FLT1, MMP2, ALAD, FBN1, ATP7B, LGALS3BP, TGFB1, SERPINA1, HGF, VEGFA, REN, IFNA1, ALB, IL6, F2, CD14, CTNNB1, ABCB4, CCN2, KRT18, KRT8, SPP1, FGF2, F3, VIM, VTN, IGFBP1, LUM, CCL2, CYP1A2, GC, FGFR2, FGF7, F5, COL1A1, PLAU, PTEN, COL1A2, STAT1, THBS1, RGN, NPC1, CNR1, CNR2, LOXL1, COL3A1, MIR29C, CP, F2R, SERPING1, MIR885, MIR30B, AHR, HSD11B2, MIR215, CD9, TGFBR1, TLR4, SERPINH1, SERPINA6, TNFRSF1B, HDAC2, DHCR7, SPARC, CYP27A1, COL5A2, IGFBP2, JUND, PLOD2, CYBA, LAMC2, LGALS1, PCOLCE, CHRM3, NPPA, LOX, SMAD3, C1QB, A2M, ANKS6, ADRA1A, SLC17A2, TRPM7, MIR30C2, ARNT, COMMD1, MIR302C, ARRB1, SLC13A4, CYP2R1, UNC93B1, PEMT, MIR376C, MIR503, TAGLN2, SLC22A8, TMEM67, MIR942, BAMBI, ACTA2, MIR764, SLC30A10, MIR21, GSTM1, FAH, DNMT1, MMP1, SPINT1, MIR145, NOS3, EDN1, FGF19, ELN, LBP, WDR35, CYGB, PDGFB, NQO1, PDIA3, PTN, PDGFD, AKAP12, RAD50, KLKB1, NR1H4, MUC2, GCLC, RGS2, PNPLA3, EGR1, MERTK, RNF7, GPT, DDX60L, FDFT1, IFNA13, GSTP1, ALDH2, IFNG, IL10, EHBP1L1, CYP2E1, IFNL3, HFE, MIR122, IGF1, HLA-DRB1, AFP, VWF, FBL, CRP, CDKN2A, TP53, SLC17A5, TNF, COL13A1, GOLM1, FARSB, CCL4, GLT8D2, CRACR2A, TFAM, ABCB11, IL17A, TM6SF2, PAEP, TERT, EGF, CAV1, TLR2, STAT3, ADH1C, CXCL8, CST3, SOCS1, RBM45, IGF2, IL18, RETN, RASSF1, ADH1B, HP, PTGS2, IL1B, LCN2, SLC25A1, SLC10A1, MBL2, ADIPOQ, AVP, CYP3A4, THPO, ACE, HAMP, ACTB, MTHFR, LOC102724197, GABPA, CCL4L2, ADAMTS13, AKR1A1, ESR1, RSC1A1, HMOX1, PPARG, LEP, IFNA2, MMRN1, PHKG2, CCL4L1, MPO, CXCL10, NOD2, MBOAT7, GGTLC1, LIPA, H3P10, CYP2C19, MDM2, FN1, CYP1A1, PROM1, APOE, GGTLC3, IL4, GGT1, IL1RN, FAS, GPC3, GLS, SOD2, MIR221, VIPR1, HSPA5, VDR, ADRB2, FGF21, GGTLC4P, CASP1, HLA-DQA1, TGFA, HIF1A, GGTLC5P, GGT2, PON1, TIMP1, SERPINE1, COX8A, MMP9, MTCO2P12, COX2, PCNA, CHI3L1, SST, HAVCR2, MIR223, MIR224, SPINK1, NGF, CLTC, CD44, PIK3CD, MST1, PRKN, TERC, CD274, MMP13, MMP8, MMP7, THBD, MMP3, CBLL2, ADAM17, SMN2, PIK3CG, IFI27, MUL1, CYBB, APOB, MIR146A, PIK3CB, PSMD9, MIR155, KDR, PIK3CA, KIR3DL1, AGTR1, CYP2D6, APC, IL2, KRT19, AQP1, TICAM2, SHBG, AQP2, SLC4A1, SMN1, RARRES2, TMED7, TIMP2, GHR, EDNRA, ZNRD2, BMP7, EDNRB, PCSK7, DCTN6, GFER, ZNF267, GEM, MSTN, TNFSF10, TMED7-TICAM2, GCG, FUT1, VIP, UTS2, OPN1SW, BCHE, LOC110806263, GSTT1, TRIO, TLR3, DNMT3B, H3P23, SOCS3, DHDDS, KHDRBS1, XPR1, DCLK1, SPRY2, BCL2, XPO4, TNFSF13B, PLA2G2A, ADIPOR2, CEACAM5, BAGE, PGF, NR3C2, APOA1, MGMT, LYVE1, CXCL9, EHMT1, KEAP1, ALPP, SERPINF1, RAPGEF5, MYC, NAGLU, AZIN2, MTFMT, DEPDC5, MUC16, CLU, CKS2, KLF2, SLC11A2, SYVN1, MINDY4, OSM, OTC, SLCO6A1, YAP1, GDF15, AVPR2, BLVRA, KL, PPIG, PECAM1, BCR, PTX3, PROX1, TAP1, EXTL3, SYNM, DDAH1, GP6, DCTN4, SMUG1, MET, SOST, NUP62, GCA, TALDO1, FOXP3, IL22, TLR7, NOX4, CD34, STS, TFPI, TFR2, TFRC, PYCARD, TNFAIP3, CAT, HPGDS, RUNX3, GNMT, XRCC1, SOX9, SQSTM1, SELP, NR1I2, PTH, CDKN1A, NAAA, RAC1, AKR1B10, BECN1, SLC12A9, CHPT1, SCN7A, CCL5, CXCL11, SFRP2, XRCC5, PDE5A, UGT1A7, AOC3, CAVIN2, ARID4B, GHRL, NBAS, KLRK1, DKK1, AXIN1, ISYNA1, CXCR4, SELENOP, NAMPT, MIR22, MIR203A, GH1, IGFBP3, SMIM1, DNMT3A, POTEF, IGF2R, GSTK1, LAIR1, ARSH, MIR199A1, GAPDH, MIR182, CSF3, DBP, HCC, MTOR, IFNAR1, LGALS3, MIR199A2, E2F1, LINC01672, IRF3, CYP2B6, CXCL1, ZGLP1, GRB2, GPX1, ATN1, MIR148A, UTS2R, GLUL, MIRLET7C, IL2RA, MIR196A2, GLP1R, GLO1, MIR125A, MIR106B, GTF2H1, JAK2, GADL1, HSD17B13, MIR17, COPD, F8, AKT1, TNC, HTR2A, PRMT1, MIR222, CPE, EP300, MIR29A, IL27, ENG, TP53COR1, MIR27A, FCGR3B, MIR34A, FCGR3A, KLRC4-KLRK1, EGFR, DCN, HNF4A, DDX5, BTBD8, MIR338, DDX53, FGFR4, EPHB2, DLAT, CR1, BMPER, ATRNL1, CCR2, HAR1B, MIR744, HOTAIR, MBL3P, MIR454, PTPN22, MIR96, GSPT2, WWTR1, RNA28SN5, CNTNAP2, SH2B1, CHMP2B, SERPINC1, MIR423, ARRB2, MSMP, ACYP2, ADAR, MYLIP, LAMTOR2, HTRA2, SFTPA1, MIR545, RBMS3, TRPM5, MIR331, ADARB1, ICOS, PDLIM3, MIR17HG, MIR571, MIR652, RMC1, KRT8P3, HULC, DKK3, NENF, FOXP1, MIR499A, NOX1, SOCS7, USP21, SLC40A1, NCOA6, SRRM2, GAS5-AS1, CIB1, MICA, NPC2, IGF2BP2, MINCR, CCAT1, CXCR6, SNHG18, CABIN1, OGA, PPP1R13L, CCL27, MIR3667, MIR3648-1, MIR3677, SUB1, VAT1, FST, ERVW-4, LINC-ROR, CALCOCO2, H3P8, SPRY1, DENND4A, RNU6-392P, CDK2AP2, MARCHF6, LARP1BP2, AZU1, AZGP1, AAVS1, PIAS3, IFITM3, IFNL4, GPNMB, RALBP1, KCNQ1OT1, COPS5, ATD, PAXIP1, NT5C2, MIR30A, SETD1B, KIF1B, MCF2L2, TBC1D9, MIR943, ACVRL1, SULF1, NUP210, SIRT3, SIRT1, ANGPTL2, MIR873, SIRT2, ACHE, HOTTIP, SYCE1L, SLC27A5, ABO, ADRM1, ESM1, ATIC, RPP14, FTX, ZWINT, ATHS, MIR1304, MIR1247, WIF1, AKAP13, VASH1, MLXIP, ADH5, PLB1, DERL2, MAGT1, ARHGAP24, NUF2, EIF1, FSD1L, IMMP2L, TMPRSS13, MACC1, NANOS3, LMLN, NANOS1, SARNP, MAK16, TRIM63, GPT2, ABCB5, AOX1, ZNF699, SHARPIN, ENHO, SERPINA13P, TNFAIP8L2, MIR126, CYBRD1, JAG1, DENND2D, MIR101-1, GUCY2EP, ASRGL1, BIRC5, CPEB4, WNT10A, BIRC3, PDCD1LG2, COL18A1, APEX1, FOXD2-AS1, UNC5A, MIR139, MARCHF8, RXFP2, HSPA12A, OSCP1, ALPI, BCL6B, ABCD1, CTAG1A, FOLH1B, ANXA5, VPS37A, CKS1BP7, ALDOB, HT, OR2AG1, TMC4, RNF187, ASPM, SPPL3, GRDX, DCD, ANXA2, CTBP1-AS, BOC, ANGPT2, SFXN1, CAVIN3, IL17F, CAVIN1, NEAT1, NLRP3, ANGPT1, NOSTRIN, ADGRF1, CTHRC1, CLNK, MIR130B, BIRC7, ADRB3, ATG16L1, IL17D, MIR214, TLR9, NANS, MIR210, AGA, PINX1, PIWIL2, TENM3, MIR20A, NAT10, STEAP3, NUDT15, MIR199B, HES6, UBE2Q1, CD244, AFM, DNAJB11, SF3B6, GMNN, ADIPOR1, ANGPTL4, JPT1, MARCHF2, MIR24-1, AR, MIR23B, THEM6, PLA1A, TRPV2, EVL, ALOX5, MIR219A1, AZIN1, TRMU, ALLC, MIR141, AGRP, SCAF1, IL21, MIR150, GER, SH2D4A, GOLPH3, VSIR, HHIP, PAG1, GORASP1, SMURF2, WNK1, FRTS1, MIR142, FSD1, MMEL1, CXCL16, ZNF410, MIR18A, CIP2A, MYDGF, CCL28, APRT, PNO1, MIR196A1, TWSG1, PDSS2, RTN4, AICDA, MAVS, APOH, MIR195, SEMA6A, MIR192, KLHL1, BCL2L12, ETV3, FAM13A, CRH, LIG4, LMNB1, CPT1A, CLDN3, LTA, CYP4F3, EPCAM, MARCKS, SMAD1, CPB1, SMAD4, MAS1, MAT1A, MAT2A, MATN2, MCAM, MCC, MCM2, MEF2A, MFAP1, MFGE8, LIF, CSF1, ENAM, LDLR, IRF7, IRS1, ISG20, ITGA2B, ITGAM, ITGB1, ITK, ITPA, KCNJ5, KIR2DS4, CX3CR1, KNG1, KIF11, CTSL, CTLA4, LAG3, LALBA, CTAG1B, STMN1, CSTB, CSN3, MIF, ATXN3, MLN, KLF6, NOTCH4, CCN3, NPM1, CKS1B, NPPB, NT5E, NUP98, OAS1, OATP1, TNFRSF11B, OPRD1, CISH, PC, PDCD1, PDE4A, PDE1B, CEACAM8, PDGFRA, PDK1, ENPP2, ATP8B1, NOTCH3, NPY, NOS2, MTTP, COMP, MMP14, ABCC2, MPV17, MSH2, MSMB, MSX2, MTAP, CCR5, MTR, NOS1, CMD1B, NCAM1, NELL1, NFATC1, NFE2, NFKBIA, NGFR, NM, NME1, IRF5, IRF1, INSRR, CFHR1, GDF2, GIP, GLB1, GLI1, GLI2, GNB3, GNRH1, GRIN2A, GRIN2B, CXCL2, SLC26A3, GSK3B, GSN, GSTA1, DPP4, GSTM2, HABP2, HARS1, HDAC1, HDLBP, HEXB, GCK, GCDH, TYMP, FDX1, ERBB2, EPAS1, FABP4, ENO1, FAP, FBN2, FCN1, FCN2, ELAVL2, EIF2S3, GALT, EIF2S1, FHIT, FHL2, FOXC2, FOXO3, FMOD, FOLH1, NR5A2, GAST, DNASE1, DMRT1, INS, HGFAC, HTR7, IAPP, ICAM1, DCC, IFNAR2, DGKB, IGF1R, CYP27B1, CYP19A1, CYP17A1, JCHAIN, IL1A, CYP4A11, IL1R1, CXCR1, IL9, IL10RA, TNFRSF9, CYP3A7, CYP2A6, IDO1, NDST1, HSPG2, HSPA9, HLA-DRB3, HIC1, UBE2K, HK3, HLA-A, HLA-C, HLA-DMA, HLA-DPB1, HLA-DQB1, DMBT1, HMBS, HSPA8, HMGB3, HMGCS2, HOXA10, DGUOK, HPD, HPX, DECR1, HSF4, HSPA4, ABCB1, CEACAM7, PHB, PLA2G6, TSC2, TTR, TYR, UCP2, UMOD, UQCRFS1, USF2, VCAM1, DDR1, VEGFC, CA9, TRPV1, KLF9, WNT2, YWHAZ, ZKSCAN1, ZNF148, MANF, ST8SIA4, NR4A3, ADAM12, TSC1, TRH, TRAF6, KLF10, TF, TNFRSF8, CD5L, TGFBI, CD1D, TGM2, CCT, THBS4, THY1, TIMP3, HSP90B1, CASR, TLR5, TM7SF2, CASP3, TNFRSF1A, CALR, TP73, TPMT, TPO, AXIN2, BSG, TEK, NR0B2, CD163, SLIT2, LHX2, PRDM1, GSTO1, AIM2, GGPS1, CIR1, MACROH2A1, CFB, BDNF, KLK4, TTC37, PPIP5K1, HERPUD1, HEPH, MFN2, BCL3, NR1D2, TANK, ABCB6, CYTH2, AURKB, FIBP, NRP1, SMARCA5, DGKE, BPI, NUMB, GPAA1, RIPK1, TNFRSF6B, IQGAP1, NRP2, DLEU2, HGS, APLN, SPHK1, EIF2S2, CCNA1, P4HA2, HSPB3, ARTN, BMP1, ARHGEF1, TEP1, TDGF1P3, PHEX, SAA1, PSMC5, PSMD10, PTBP1, CDKN2B, PTGDS, CDKN1B, QSOX1, RAB27A, RARB, RASGRF2, RB1, RBP1, RBP4, RELA, CDK5, CDH13, RNH1, RNU1-4, RPS27A, RRM2, CDH11, PSG2, KLK10, PROS1, PRRX1, CEACAM3, CEBPA, PIGR, PIN1, PLA2G1B, PLA2G4A, PLG, CDO1, PLXNA2, POMC, PROC, CDKN3, PPP2CA, PRKAA1, PRKAA2, PRKAB1, MAPK1, MAPK8, PRL, PRLR, S100A9, SAA2, TDGF1, TSPAN31, SNCA, SNCG, SOD1, SOX1, CD63, CD47, SPTBN1, SRC, SRY, SSTR2, ST14, ENTPD1, CD36, STAT4, SYK, SYT1, TALDO1P1, TAP2, TAT, TAZ, HNF1A, SIGLEC1, SMARCA4, SMARCA2, SFRP5, SERPINB3, CDH1, CDK1, CCL14, CXCL5, SDC1, CXCL12, AADAC, SFRP1, SRSF3, SMARCA1, SRSF5, ST6GAL1, SKP2, SLC2A4, SLC6A3, CD69, SLC11A1, CD68, SLPI, VPS51
    • Cirrhosis Mayo Clinic
      Overview Cirrhosis is severe scarring of the liver. This serious condition can be caused by many forms of liver diseases and conditions, such as hepatitis or chronic alcoholism. Each time your liver is injured — whether by excessive alcohol consumption or another cause, such as infection — it tries to repair itself. In the process, scar tissue forms. As cirrhosis gets worse, more and more scar tissue forms, making it difficult for the liver to do its job. Advanced cirrhosis is life-threatening. The liver damage caused by cirrhosis generally can't be undone. But if liver cirrhosis is diagnosed early and the underlying cause is treated, further damage can be limited.
  • Major Depressive Episode Wikipedia
    American Family Physician . 82 (8): 926–933. PMID 20949886 . ^ a b c Walls, Ron M., MD; Hockberger, Robert S., MD; Gausche-Hill, Marianne, MD, FACEP, FAAP, FAEMS (2018).
    HTR1A, HTR2A, TPH1, S100A10, DRD2, HSPA1B, KYAT3, HSPA1L, HSPA1A, APOA1, CRTC1, APOA4, HTR2C, NOS1, SLC6A4, BDNF, WASF1, TNF, GSK3B, VEGFA, MIXL1, APOE, ATF7IP, TRIT1, TARDBP, PPARGC1A, PDLIM5, CLOCK, XBP1, TSPO, GATA3, TAT, S100B, CACNA1C, PRL, CREB1, MAOA, IL10, CRHR1, FKBP5, HTR1B, ECT
    • Major Depressive Disorder Wikipedia
      For other types of depression, see Mood disorder . Not to be confused with Depression (mood) . Mental disorder involving persistent low mood, low self-esteem and loss of interest Major depressive disorder Other names Clinical depression, major depression, unipolar depression, unipolar disorder, recurrent depression Sorrowing Old Man ('At Eternity's Gate') by Vincent van Gogh (1890) Specialty Psychiatry Clinical psychology Symptoms Low mood , low self-esteem , loss of interest in normally enjoyable activities, low energy, pain without a clear cause [1] Complications Self-harm , suicide [2] Usual onset 20s–30s [3] [4] Duration > 2 weeks [1] Causes Genetic , environmental, and psychological factors [1] Risk factors Family history , major life changes, certain medications , chronic health problems , substance abuse [1] [3] Differential diagnosis Bipolar disorder , ADHD , sadness [3] Treatment Counseling , antidepressant medication , electroconvulsive therapy , exercise [5] [1] Frequency 163 million (2017) [6] Major depressive disorder ( MDD ), also known simply as depression , is a mental disorder characterized by at least two weeks of pervasive low mood . Low self-esteem , loss of interest in normally enjoyable activities, low energy, and pain without a clear cause are common symptoms. [1] Those affected may also occasionally have delusions or hallucinations . [1] Some people have periods of depression separated by years, while others nearly always have symptoms present. [3] Major depression is more severe and lasts longer than sadness , which is a normal part of life. [3] The diagnosis of major depressive disorder is based on the person's reported experiences and a mental status examination . [7] There is no laboratory test for the disorder, [3] but testing may be done to rule out physical conditions that can cause similar symptoms. [7] Those with major depressive disorder are typically treated with counseling and antidepressant medication . [1] Medication appears to be effective, but the effect may only be significant in the most severely depressed. [8] [9] Types of counseling used include cognitive behavioral therapy (CBT) and interpersonal therapy , [1] [10] and electroconvulsive therapy (ECT) may be considered if other measures are not effective. [1] Hospitalization may be necessary in cases with a risk of harm to self and may occasionally occur against a person's wishes . [11] The most common time of onset is in a person's 20s and 30s, [3] [4] with females affected about twice as often as males. [3] [4] Major depressive disorder affected approximately 163 million people (2% of the world's population) in 2017. [6] The percentage of people who are affected at one point in their life varies from 7% in Japan to 21% in France. [4] Lifetime rates are higher in the developed world (15%) compared to the developing world (11%). [4] The disorder causes the second-most years lived with disability , after lower back pain . [12] The term major depressive disorder was introduced by a group of US clinicians in the mid-1970s. [13] The cause of major depressive disorder is believed to be a combination of genetic , environmental, and psychological factors, [1] with about 40% of the risk related to genetics. [3] Risk factors include a family history of the condition, major life changes, certain medications, chronic health problems , and substance abuse . [1] [3] It can negatively affect a person's personal life, work life, or education as well as sleeping, eating habits, and general health. [1] [3] Those currently or previously affected with the disorder may be stigmatized . [14] Contents 1 Symptoms and signs 1.1 Associated conditions 2 Cause 2.1 Genetics 2.2 Other health problems 3 Pathophysiology 4 Diagnosis 4.1 Clinical assessment 4.2 DSM and ICD criteria 4.2.1 Major depressive episode 4.2.2 Subtypes 4.3 Differential diagnoses 5 Screening and prevention 6 Management 6.1 Lifestyle 6.2 Talking therapies 6.2.1 Cognitive behavioral therapy 6.2.2 Variants 6.2.3 Psychoanalysis 6.3 Antidepressants 6.4 Other medications 6.5 Electroconvulsive therapy 6.6 Transcranial magnetic stimulation 6.7 Transcranial direct current stimulation 6.8 Light therapy 6.9 Other 7 Prognosis 8 Epidemiology 9 History 10 Society and culture 10.1 Terminology 10.2 Stigma 11 Elderly 12 Research 12.1 Animals models 13 References 13.1 Cited works Symptoms and signs An 1892 lithograph of a woman diagnosed with depression Major depression significantly affects a person's family and personal relationships , work or school life, sleeping and eating habits, and general health. [15] Its impact on functioning and well-being has been compared to that of other chronic medical conditions, such as diabetes . [16] A person having a major depressive episode usually exhibits a low mood, which pervades all aspects of life, and an inability to experience pleasure in previously enjoyable activities. Depressed people may be preoccupied with—or ruminate over—thoughts and feelings of worthlessness, inappropriate guilt or regret, helplessness or hopelessness. [17] In severe cases, depressed people may have symptoms of psychosis . These symptoms include delusions or, less commonly, hallucinations , usually unpleasant. [18] Other symptoms of depression include poor concentration and memory (especially in those with melancholic or psychotic features), [19] withdrawal from social situations and activities, reduced sex drive , irritability, [20] and thoughts of death or suicide.
  • Parkinson's Disease Wikipedia
    As the disease progresses, Lewy bodies develop in the substantia nigra, areas of the midbrain and basal forebrain and, finally, the neocortex . [70] These brain sites are the main places of neuronal degeneration in PD; however, Lewy bodies may not cause cell death and they may be protective (with the abnormal protein sequestered or walled off). Other forms of alpha-synuclein (e.g., oligomers ) that are not aggregated in Lewy bodies and Lewy neurites may actually be the toxic forms of the protein. [81] [82] In people with dementia, a generalized presence of Lewy bodies is common in cortical areas. ... Therefore, it is recommended that people with PD should perform exercises 45 minutes to one hour after medications when they are at their best. [134] Also, due to the forward flexed posture, and respiratory dysfunctions in advanced Parkinson's disease, deep diaphragmatic breathing exercises are beneficial in improving chest wall mobility and vital capacity. [135] Exercise may improve constipation. [17] It is unclear if exercise reduces physical fatigue in PD. [125] One of the most widely practiced treatments for speech disorders associated with Parkinson's disease is the Lee Silverman voice treatment (LSVT). [129] [136] Speech therapy and specifically LSVT may improve speech. [129] Occupational therapy (OT) aims to promote health and quality of life by helping people with the disease to participate in as many of their daily living activities as possible. [129] There have been few studies on the effectiveness of OT and their quality is poor, although there is some indication that it may improve motor skills and quality of life for the duration of the therapy. [129] [137] Palliative care Palliative care is specialized medical care for people with serious illnesses, including Parkinso
    SNCA, PINK1, DRD2, TH, DDC, MAOB, ATP13A2, PRKN, SLC18A2, PARK7, DRD1, IGF1R, LRRK2, BST1, MAPT, GBA, GAK, HLA-DRA, CYP2D6, CP, PPARGC1A, TNF, SOD2, SOD1, BDNF, ABCB1, VPS35, IL6, NOS1, PARK16, MTHFR, GDNF, GFAP, TMEM230, MAOA, DNM1L, GSTM1, HFE, HMOX1, HSPA9, SLC6A3, DDIT4, GSTP1, CYP2E1, MAP3K5, NGF, AIF1, NQO1, IGF2, GSTA4, TRPM2, IGF2R, INS, HLA-DRB5, GPX1, TCL1B, MIR181C, MTA1, ENO2, BAG5, MAG, FCER2, HGF, HSPA1A, FBP1, INSR, HSPA8, NCAPG2, HBG1, RPL23A, GSK3B, HSPA4, NR4A2, RPS8, COL19A1, TALDO1, SLC30A10, DRAXIN, PITX3, CNTNAP2, NECTIN2, IL1B, ADARB2, CEACAM6, TFAM, MAP2, EDN1, FGB, KCNJ4, RPL6, RPL14, SLC2A14, OPTN, SPR, TWNK, ATG7, GRK5, HTR1A, PENK, GDF5, PPP1R9B, ADH7, DLG4, ABL1, HSF1, LEP, PTN, HSPD1, ND3, GRK6, DLG1, DBN1, ADCY5, HCN3, CCN2, FEZ1, APOE, FASLG, COX10, GJC2, RRN3, RIT2, GCH1, ARPC3, GRK3, GRK2, STK39, LAMP3, SLC41A1, CCDC62, MCCC1, GPNMB, DGKQ, TMEM175, VPS13C, STH, HLA-DRB1, SIPA1L2, CTSB, SREBF1, HIP1R, NUCKS1, MAPT-AS1, RAI1, BCKDK, BIN3, RREB1, TCEANC2, TPM1, PAM, DLG2, ITPKB, MMRN1, KANSL1, FAM47E, ITGA8, LHFPL2, SH3GL2, LMNA, FAM47E-STBD1, NSF, INPP5F, TMC3-AS1, CCDC82, DRD3, SLC50A1, DSCAS, MUL1, RABEP2, NOS2, MANF, ADORA2A, WBP1L, AIMP2, PLPPR1, PTEN, GBF1, EEF1A2, DNAJC1, BAP1, NEFL, SQSTM1, PIP4P2, EIF4G1, PLA2G6, GPR65, MX2, ESR1, PDSS2, NFE2L2, TBC1D5, LINC02224, SMUG1, HTT, SIRT1, TARDBP, SF3B1, GSTT1, LAMC2, GRM5, LRRK2-DT, FRY, FBXO7, GRIN2B, RNF19A, GRN, LINC02451, ACHE, SYNM, RAB29, AHSA1, IL1A, IL10, IGFALS, IGF1, CIT, ITIH1, SIRT2, MCF2L, RET, LOC107987479, TBC1D9, MPHOSPH6, SYT11, TNK2, GPR37, GIGYF2, POLDIP2, MAP4K4, SNCAIP, IP6K2, FYN, MTOR, ATXN3, SYT17, FMR1, FGF20, DCUN1D1, GRAP2, TREM2, MPZ, TET2, CNNM2, GABPA, CHCHD2, GAPDH, ZNF646, GBAP1, GCG, LINC02210-CRHR1, LINC02471, CTNNA3, REM1, HTRA2, HPGDS, GLP1R, CTIF, LY6E, PLEKHM1, LRP2, KCNIP4, ATXN2, ZP3, PARK3, TPTE2P6, PM20D1, LINC02210, MAPK1, TP53, TPO, LINC01121, SLCO6A1, DPY19L2P3, CA8, CDNF, TYW1B, APP, POLG, CNTN1, COL5A2, COL13A1, KLHDC1, COMT, BORCS7, AGAP1, CRHR1, CRK, PIK3CD, CRP, RAB39B, GSTK1, TLR4, CHM, CASP3, PIK3CG, PRSS53, PIK3CB, PIK3CA, TMC3, ALDH1A1, C9orf72, NAT2, ASXL1, PARK10, SPTSSB, SPPL2C, CDH8, CDK5, PRNP, MCIDAS, MDGA2, TMEM229B, PTGS2, CBLL2, THY1, CNKSR3, CASC16, TMPRSS9, SNCA-AS1, NLRP3, RPA2P1, MAPK14, NDUFAF2, UCHL1, SMPD1, YWHAE, BCHE, ALDH2, BCL2, SCN2A, CCL2, AKT1, LINGO1, WNT3, VDR, SLC45A3, CYP17A1, MAPT-IT1, UNC13C, SNCG, CCNT2-AS1, ADAMTSL1, CTSD, TPTE2, BORCS7-ASMT, ZNF165, PREP, SLC2A13, PON1, SNCB, BRINP1, CSF2, ACE, PAFAH1B1, ZSCAN16-AS1, NRTN, CAB39L, DBH, VEGFA, HCRT, GAD1, FUS, SLC11A2, CXCL8, SLC6A4, PARP1, CRMP1, DENR, PPARG, ULK1, DNAJC13, P2RX7, REG1A, IFNG, UTRN, MIR133B, DAPK2, LAMP2, APLN, CTNNB1, TYR, HIF1A, ESR2, PAEP, HNMT, CYP1A2, MC1R, EHMT1, LRRK1, ACMSD, CALB1, USP24, NUP62, CASP9, GRIN2A, TSPO, S100B, CAT, LMX1A, TAC1, GTF2H1, UBE2K, SIRT3, TLR2, LINC01672, DYRK1A, CNR2, ADRB2, CNR1, PDE10A, SYNJ1, HSP90AA1, KHDRBS1, SLC1A2, TPPP, ANG, DNAJB1, ZGLP1, CHRNA4, RMDN3, SCARB2, GIP, LILRB1, DCTN4, PSPN, ROS1, TGFB1, ACTB, SERPINA3, DECR1, IL17A, GRM4, PSPH, CRYZ, STX1B, HTR2A, SLC6A2, BPIFA2, STXBP3, MSMB, MPO, AGER, MAPK8, MEF2D, LMX1B, RIDA, HMGB1, CAV1, CXCR4, CYBB, TOMM40, POTEKP, CCR2, REST, MIR433, AQP4, AGFG1, POTEM, SIGMAR1, ACOT7, ACTG1, MIR34B, ZFPM1, RPS27A, RMDN2, CLOCK, FHL5, NMS, COX2, GSTO2, SUCLA2, SYBU, UBC, BECN1, CST3, CYP1A1, NTS, NNMT, NTF3, DRD4, TFEB, PPP1R2C, RMDN1, MMP9, NQO2, MIR221, TBP, ACTG2, ACTBL2, STAT3, CHMP2B, MFN2, CHCHD10, GSTM2, DNAJC6, GLA, CCK, PLK2, NEDD4, NPC1, VCP, PICALM, NGFR, SYP, SEPTIN4, TRPV1, PTPA, NPY, XBP1, LCN2, TFRC, MAPK3, SKP1, AKR1A1, PRDX2, GDF15, GSTO1, MMP3, LAG3, KLK6, OGA, PSEN1, DNAJB6, PHOX2B, CDK5R1, CXCL12, TCF3, CX3CL1, A2M, REN, CREB1, SNHG1, MIR34A, MIR205, DNM3, MALAT1, NEAT1, GLRX, RLS1, DNAJB1P1, LINGO2, ZNF746, CUX1, SV2C, CYP2D7, DMRT1, NIF3L1, ELAVL4, FKBP1A, ELK3, EPHB1, SLC2A9, FGF2, PTK2B, FABP3, ATF4, RHOT1, MIR4697, HP, HSPA5, ADCYAP1, ICAM1, APOA1, IAPP, CX3CR1, MAP1LC3B, WNT1, AGT, CYP2B6, VIPR2, OGDH, OGG1, VDAC1, APRT, NRGN, P2RX3, VCAM1, AGTR1, UCP2, CTSL, PEBP1, UBB, PINK1-AS, PROKR2, TMEM163, RAB10, NRF1, ADH1B, MOK, RAC1, NR1I2, PARL, F2, ACP3, RAB1A, EPHB2, MARK2, NDUFV2, TRPC1, NEDD9, PVALB, RTN4R, RIC3, HSD3B7, DNMT1, ADH1C, DNAJC5, YWHAZ, TSC2, CLU, PCNA, PACRG, PSMC4, PON2, PPARA, PPARD, MIR29C, PRKAA1, HOTAIR, PRKAA2, PRKAB1, AVP, SMN2, SMN1, PRKAR2A, PRKD1, SGCA, MIR135B, ASAH1, ARNTL, WASH6P, FAS, SKIL, APEX1, MIR200A, SEPTIN5, ATXN8OS, SIAH1, PDE4A, CHRM3, PDYN, TIMP2, ALB, CFP, CDKN2D, CDKN2A, CD38, MIR19B1, WASHC1, USP40, APAF1, PIN1, CASP1, CALCA, SST, PNOC, MIR195, TFR2, IL4, DCTN1, DCDC2, FKBP1AP2, FOXA2, TRAP1, ATG12, GAP43, GRIA2, FKBP1AP3, FKBP1AP4, PRRX2, HMOX2, FTL, MSC, MEFV, FKBP4, ISYNA1, GPX4, NCS1, PPIG, FOXO1, LSAMP, TLR9, LGALS4, MACF1, LAMP1, LRPPRC, ATG5, GRIN2D, MFAP1, BAG3, LDLR, LRP10, GRM2, IREB2, KEAP1, COQ2, FAF1, SBNO2, VPS41, SGSM3, NOX1, SEMA5A, IL1RN, PSIP1, FKBP1AP1, TOMM20, CYP4F3, SLC40A1, PTPN22, GLUD2, SBNO1, IL18, MIR27A, MIR185, MIR137, SNAP25, MIR132, MIR126, TAL1, MIR29A, SP1, SRY, PPIF, MIR204, SPG7, SPP1, FBXO8, MIR21, HDAC6, MIR212, MIR223, USP15, MIR22, RNF11, SOAT1, SNRPF, SNRNP70, SOD3, BDNF-AS, BACE1, FST, ARL6IP5, NLRP1, P2RX5-TAX1BP3, SCD, TXNIP, MGLL, CHP1, MIR4519, HRH3, NES, OPN1MW3, RIPK3, RAB32, TMED10, RNASE4, RNASE1, MTCO2P12, PRSS21, TRIM27, RFC1, LINC02605, H3P13, RENBP, CCL5, P2RX2, ATP6AP2, ABCA7, SMARCA1, CD2AP, SLC22A1, SLC18A3, SRRM2, MIR326, SLC16A1, SLC8A1, MIR494, MIR505, ARC, UCA1, RNF41, MPRIP, HMGXB3, ST3GAL2, MIR563, SI, SHMT2, TRIM32, SHMT1, OPN1MW2, SGTA, SIGLEC7, SPHK1, ERCC6L2, TET1, P2RX6, AXIN2, NEUROG2, NOD2, FBRS, HS1BP3, DDRGK1, SLC52A2, PANK2, MAP3K13, NELFE, H3C1, RAB7A, XPR1, COASY, ZNF184, NDFIP1, EGLN1, MFHAS1, GPR55, KLF4, RNF146, HIVEP3, H3C4, XIST, TMED9, TRPM7, CISD1, RIPK1, DNAJC12, B3GALT4, H3C7, PDE8B, KHSRP, SLC17A6, MGAM, STBD1, H3C3, NOL3, SEMA6A, H3C2, H3C10, H3C12, TMEM106B, H3C8, H3C11, H3C6, TRIB3, C19orf12, SESN2, TCOF1, TIMP3, TRAF2, MZB1, SESN3, GAL, TNFRSF1B, PWAR1, TRAT1, PLB1, TLN1, HDAC4, ATG13, CD200R1, TAS2R13, BMS1, RMC1, EIF2B3, MCAT, MTIF3, ANKK1, PGP, RAB7B, HCAR2, TRH, TTR, PPP1R1B, IL23A, SYVN1, GPR88, HOMER1, SHC3, VIM, ATAD1, MIDN, SELENOT, ROCK2, SLC25A27, DNER, TPH2, USP1, SCLY, UCHL3, FTMT, OPN4, UBE2L3, TXNRD3, VPS26A, CARD16, TXN, TGM2, TGFB2, IDUA, CHRNA5, HK2, LGALS1, BAG1, PLA2G1B, F9, HLA-C, LBP, E2F1, BAX, CLK1, NCL, HCN2, F2R, NR4A1, FOXA1, NDUFA1, NDUFA2, NDUFS3, PLD2, HK1, HOXD13, TOR1A, COL17A1, COL11A2, PPID, FCGR3A, POU2F1, POMC, POLB, ARSA, ASCL1, LGALS3, HCLS1, PLXNA2, LIFR, FAAH, ATM, ATOX1, NRG1, ATP1A3, BNIP3L, NDUFS4, PDIA3, CBS, P2RY2, IL7, KCNJ6, P2RY1, P2RX5, P2RX4, P2RX1, OPRL1, CCKAR, KDR, GPR143, NUCB2, IL13RA1, ISG20, ITGAM, NTRK2, NT5E, CD19, IL2RB, IL2RA, EGF, PCP4, HRES1, NEFM, CHAT, CTSC, ERG, CEBPB, PDC, NFKB1, EGR1, CAST, HTC2, CACNA1A, NHS, HTR1B, KRT7, IDE, CAPN1, NOS3, COX8A, ELAVL2, FRAXE, CBLIF, RBM3, PSMB8, DDIT3, CD200, DAPK1, CSF3, PSEN2, APOD, PSAP, CYTB, GPX7, APOB, DNMT3B, MFGE8, ADCYAP1R1, FXN, GLB1, PTBP1, GLUL, GRP, FTH1, PTPRC, ALOX5, AKR1B1, MSRA, ADH4, MEF2C, GAD2, AHR, GALC, MS, DPEP1, FOSL2, ND1, ATF2, CYP3A4, DRD5, MIF, ACACA, MTRR, NR3C1, MTR, DPYSL2, MAPK10, DPP4, KLK3, ND5, MRC1, FOXO3, OPN1MW, GC, CD55, ND2, CRY1, SLC39A8, FSD1L, SNX6, CYP27B1, KREMEN1, TNMD, DLGAP3, EHHADH, ANO3, GBA2, CYP3A5, TINAGL1, MAK16, DTNBP1, EIF2B1, NEUROD6, LSM2, ATP13A4, MINDY4, DAPK3, TLCD3B, FKBP10, EIF4E, PROK2, EIF4EBP1, HAPLN2, HAMP, LGR6, ACE2, EIF4A2, LIN28A, APH1B, PAGR1, DOCK3, SLC8B1, ASPSCR1, ELOVL7, FA2H, DHRS11, BRCC3, FSD1, CWC22, DHDDS, XYLT2, DVL1, DUSP8, TNFAIP8L2, MCPH1, PEAK1, NEIL1, RTL10, ATN1, DUSP2, DUSP26, DMPK, DLD, TIMM8A, SLC25A28, TFB2M, MS4A6A, EGFR, MEGF8, HIF3A, RAB1B, CSMD1, DAXX, DBI, DCC, DCN, TAS1R2, ZNF436, PDIA2, EEF2, RAPH1, TNKS2, EEF1A1, FYCO1, REL, USP37, FBXO42, FPR2, WWOX, INPP5K, IL17D, PANK1, FN1, PPIL3, IMMTP1, AFF2, FLNB, H2BS1, FKBP5, TREM1, WNT4, FKBP3, ATG16L1, FKBP2, UGT1A9, FKBP1B, FGG, MARCHF5, FGF13, FGF9, FGF8, NDE1, FGF1, GPC4, FDXR, ANKHD1, FCGR3B, VPS29, TRAPPC2L, NUB1, FKBP7, GDF1, DPP7, PSAT1, UBQLN2, UBQLN1, SLC39A2, OBP2A, VSX1, NOX4, ASAP1, GATA2, SOST, TMED7, ST8SIA3, NMD3, POLR1D, GALNS, TFB1M, B4GALNT1, TRIM17, GABBR1, TRAPPC4, G6PD, GAST, HSD17B7, FRAXA, SIRT7, RAB6B, PPIL1, HEATR3, OXR1, SH3RF1, PELI1, EPRS1, NPDC1, TCIM, PNO1, EPO, PAK6, ARNTL2, ZGPAT, RGMA, EPHX2, CASS4, TIGAR, EPHX1, PGLYRP4, ENDOG, THAP1, ANKRD50, VN1R1, MCOLN1, CYP20A1, NDRG2, PPM1H, ZNF512B, NLN, XPO5, GPR158, NUFIP2, NCEH1, ELF4, ELAVL1, ERBB2, ERBB3, CTNNBL1, ZNF253, MTPAP, FCGR2B, MAP1S, FASN, RCBTB1, ADI1, QRSL1, F12, FBXW7, CHDH, YOD1, TRPV6, GPRC5D, SAGE1, SMPD3, F2RL1, SOX6, AMBRA1, EZH2, MECOM, ARFGAP1, MBD5, VPS11, ESRRG, PSENEN, GPRC5C, ERN1, MYO5C, MYDGF, MAP1LC3A, CRY2, EBPL, GET3, MIR342, MIR335, MIR331, ASIP, MIR324, MIR148B, GPR166P, SPAG11A, VN1R17P, ATP5F1B, ATP7A, ATR, MIR96, MIR34C, PLF, MIR425, FBXO48, MIR410, ARRB1, MIR520D, ARR3, MIR486-1, ARG1, POU5F1P3, ARF3, AR, POU5F1P4, CCDC154, NORAD, LINC00273, AQP9, ADGRB1, MIR320A, MIR30E, MIR19A, MIR107, CA12, CA2, MIR134, C4B, MIR142, MIR144, MIR15B, MIR181A2, C4A, MIR183, C1R, MIR190A, KLF9, BRAF, MIR30C2, DST, BMX, BMP2, BMI1, MIR214, MIR217, BGLAP, CFB, MIR222, BCR, MIR27B, BCL2L1, MIR30A, MIR30C1, CXADRP1, AQP1, MIRLET7D, PGR-AS1, LOC102724334, MIR8061, LOC101928100, ADORA1, UCHL1-AS1, TLE5, APLNR, OCM, ERVW-4, MIR4639, ALAD, MICOS10-NBL1, AMFR, BIN1, CBSL, HAGLROS, TP53COR1, APOA1-AS, SNHG14, ADAM10, ADA, ACO2, SIRT1-AS, BUB1B-PAK6, ACO1, ASIC2, LOC110366354, LOC110806262, AOC1, ABCA1, H3P17, MIR3143, ANGPT1, TMED7-TICAM2, PLIN4, MIR545, MIR542, PARK12, MIR561, MIR579, MIR590, MIR599, MIR613, MIR625, MIR626, MIR634, ATXN8, POTEF, APOC3, MIR671, C4B_2, XIAP, VTRNA2-1, MIR543, APC, MUPP, APBB1, ANXA5, ANK2, ANK1, CD24, MIR1224, MFT2, ANGPT2, TIMM23, MIR100, CALB2, SPZ1, KLF6, CCR7, ABCC2, CNGA1, CNTF, GPR139, MTFMT, CPOX, CHI3L1, CRAT, EXOSC6, MRGPRX4, MRGPRX3, RAB3IP, NUS1, GNPDA2, CCR5, GPR151, CCR3, PXDNL, CMA1, SIRPA, STK35, CACUL1, CLN3, CHRNB4, ZFP90, CHRNB3, ZNF569, GLIS1, PDIK1L, FBXO41, PGLYRP3, PGLYRP2, EEF2K, PLXNA4, CYP2C9, USP30, PTPN5, ORAI1, CYP2C19, CYP1B1, PPIL4, DNAJC14, CYLD, CHRFAM7A, CYC1, MCU, IL33, TRIM41, DEPDC7, CRYAB, CXADR, MTDH, CTSZ, CTSK, PRDM6, CTRL, CADPS2, CTNS, CSNK1D, TGS1, NACC1, TRIM9, CSF1R, CSF1, CHIT1, CEL, HSP90AB2P, TMED10P1, CASR, GOLGA6A, CPP, RSPO2, CAV2, RUNX1, PPIL6, SHOC1, FBXW12, ZNF763, LYPD5, CCKBR, CCND3, OR10A4, NANOS3, HSD17B13, PFN3, CASP8, CASP7, SEPTIN14, AMIGO2, HCN1, TICAM2, CASP6, NDUFS7, CALR, CALD1, CALCR, TMEM189, TMEM189-UBE2V1, UOX, CD14, SELENOH, MRGPRX1, ARID2, CDKN1B, CDKN1A, FSIP1, CDK6, CDC42, TMPRSS6, OXER1, CDK1, DDX53, CDA, CD69, RHOV, CD59, CD47, MLKL, GPX6, CDCP2, PRSS55, CD44, CD36, TPCN2, ZUP1, GPRC6A, CD34, IL27, LCLAT1, EBF3, PHYHD1, CD28, GK5, HOOK2, GPR3, USP25, UMOD, VHL, VGF, OPA1, OPRM1, UQCRH, UQCRFS1, UCP1, NPPC, UCN, P2RY6, P4HB, UBTF, UBE3A, UBE2V1, OMP, VIP, VIPR1, VSNL1, WAS, WFS1, NUCB1, WNT5A, NTRK1, NTF4, XK, XRCC1, XRCC3, YWHAG, YWHAH, NPTX2, CNBP, PRDX1, PAH, SERPINE1, TRAF6, PECAM1, TKT, PDR, PDPK1, PDHA1, TM7SF2, PDE1B, PDE7A, PDCD2, PDB1, TPT1, CRISP2, NR2C1, HSP90B1, PCNT, TYROBP, PCMT1, TRPC6, SERPINA5, PAX4, PHLDA2, TST, PAWR, TUBA4A, TUFM, TNFRSF4, REG3A, TXNRD1, TYMS, PAK1, ZSCAN21, NPPB, EIF2S2, MYOC, PEA15, MYL4, EIF3A, HSD17B6, TP63, PSMG1, USO1, NPPA, PRKRA, CASK, NAGLU, PDXK, NBL1, LGR5, MYD88, SNX3, MYCN, MYC, TNFRSF14, FADD, SNAP23, RGS9, MTX1, FGF18, CCN6, TRNL1, ASAP2, MTTP, MTNR1B, FUBP1, EIF2B4, CHST1, DGKD, NUBP1, SLC14A2, MAP3K12, PRDM2, LRP8, TUBA1A, NPM1, NPAS2, NOTCH4, ST8SIA4, NOTCH2, LAP, NKTR, CSRP3, FGF23, SLC7A5, MLRL, CUL1, SYN3, GTPBP6, NFKBIA, AXIN1, NFKB2, FZD4, NFE2L1, NFE2, NEK1, NEFH, NEDD8, NDN, NR0B2, NCK2, SERPINF1, TIMP1, TIAL1, PSMC1, PSMA2, SGK1, SELENOP, SELE, SEL1L, PSMB9, PSMD11, PER1, CCL3, SCN9A, SCN8A, TAS2R38, SCN1A, PTGER2, PSG5, SHH, HTRA1, KLK7, PRSS2, LGMN, PROS1, SLC1A1, PROP1, SLC1A6, SLC2A1, SLC2A4, PROC, PRL, MAP2K7, SLC6A8, SLC6A11, PTGER4, PTH, SATB1, ROCK1, RB1, RAP2B, RAP1B, RAN, RGS2, RGS4, RGS10, RHEB, RAD51B, RING1, RAD51, RAB6A, RNH1, RNY1, RAB3B, SAT1, QDPR, PTX3, RPL32, RPS6, RPS6KB1, PTPRA, RRAS, PTPN6, RTN1, RXRA, S100A9, S100A10, QSOX1, SALL1, SLC6A13, SLC7A1, MAP2K6, DYNLT3, CDKL5, STXBP1, SERPINF2, ABCC8, PLEK, PLG, ADAM17, TACR1, TAF1, PLD1, TAP1, CNTN2, PLAG1, PKD1, PITX2, STAT4, TEF, TMBIM6, TF, PIK3C2B, TFDP2, PIGC, SERPINA1, PHF1, SLC25A3, PHB, PGK1, THAS, THBS1, THOP1, STIM1, PLK1, SLC8A3, PPP3R1, SLC11A1, MAP2K2, PRKCG, SLC19A1, SLC20A2, PRKCD, SLC22A5, PRKAR1B, PRKAR1A, PRKACB, PRKACA, SMPD2, SMS, PPY, PPP4C, STAT1, PPP2R2B, PPP1R1A, PPBP, MED1, POU5F1, SORL1, SOX2, SPN, PODXL, PNMT, SPTBN1, PRRX1, FXYD1, ST13, EIF2B2, ENDOU, GFPT1, SARM1, HLA-A, HLA-B, ACSBG1, HLA-DQB1, KDM6B, CUL9, SMG1, GSR, TNIK, FAIM2, HLF, HNF4A, HNRNPA1, SEPHS1, SATB2, NEDD4L, HEXA, ZNF629, NCSTN, HDAC2, DICER1, SIRT5, HDAC1, HCRTR1, TPSD1, HAS2, ATP1B4, HSD17B10, ABCA5, TRAM1, GTF2H4, TLX2, RPH3A, HPD, RER1, MRPS30, JTB, PNPLA6, SUGT1, PAPOLA, RALBP1, PRDX3, IKBKB, IGHG3, COPS5, IMMT, RAB35, IFNAR1, STMN2, HTR6, DLGAP4, SLC2A6, PTGDR2, HSPB2, HSPB1, COPE, ECD, FKBP9, HSPA1L, PDAP1, TUSC2, GABARAP, HSPA1B, GABARAPL2, RRAS2, ZFYVE26, SEC14L2, MBD2, PDE7B, GLI1, RBMS3, SIT1, GLI2, GPR78, AGO2, CACYBP, LPAR3, CACNG5, B3GAT1, GLS, GLUD1, GNAL, ACAD8, TOX3, GJB2, GJB1, MAT2B, TOR2A, GHSR, GIT1, ACAD9, FLVCR1, MCTS1, DBNL, HIPK2, GHR, SETD2, SCG3, PYCARD, TBK1, ATP2C1, GNAQ, SEC22A, ARIH1, GSPT1, PDSS1, OPN3, MKRN2, GRM8, GRM3, LDOC1, PPP1R15A, SLC7A11, PPIL2, MAFF, GRIN2C, ATXN10, NOCT, TPSG1, CHORDC1, PRDX5, BACE2, PART1, GRIN1, GRIK3, GORASP2, FFAR1, GPER1, MCHR1, GPR17, UTS2R, FBXO2, FBXO9, GPR6, IL9, PPP1R13L, IL13, MICD, MAP3K3, RAB8A, PTGES, MGMT, TMEM59, NPEPPS, TBX4, PPP1R17, MAPK8IP1, MIP, MAP3K11, SH3BP5, KMT2A, AFF1, DNAJB9, ISG15, MCL1, HERPUD1, MBP, SART3, HDAC9, SETD1A, CLSTN3, PHACTR2, MATN3, MAS1, MARK1, PIEZO1, MAP6, MAP1B, CD180, AFDN, NR3C2, MME, MSX1, MTHFD1, NUDT1, USP13, MT3, HSPB3, PGLYRP1, MT2A, SOCS3, MT1E, ERDA1, MT1B, MT1A, PIAS2, USP10, AIFM1, COX5A, OSMR, SLC16A7, SLC33A1, VAPB, MOG, MMP8, GPR37L1, MMP7, MMP2, TAOK2, MMP1, LONP1, KL, ADIPOQ, LTF, LTA, LRPAP1, NXF1, SPRY1, STUB1, DNAJA2, KLC1, DLEU1, KNG1, CCL26, KLK2, NPM3, NDRG1, SPAG11B, UBAC1, KIF2A, KCNMA1, CIB1, CALCOCO2, PROCR, KCNA5, ARFGEF1, NPC2, SCGN, JUP, TRIM3, ITPR3, YKT6, ITPR1, ITGB2, PTGES3, GJB6, CPLX1, KRT10, STX6, HEPH, LPA, PSMD6, SV2B, SRGAP3, RBM19, NCAPD2, SEC16A, LRP6, LRP1, USP3, MVP, NR1I3, SRA1, LPO, BCL2L11, ABCB6, EIF1, LIG4, PTPRU, PQBP1, LIF, TRIM10, LCN1, G3BP1, RPSA, WASF2, LAMB2, LAD1, L1CAM, KRT31, TRIM13, H3P42
    • Parkinson's Disease Mayo Clinic
      Overview Parkinson's disease is a progressive disorder that affects the nervous system and the parts of the body controlled by the nerves. Symptoms start slowly. The first symptom may be a barely noticeable tremor in just one hand. Tremors are common, but the disorder may also cause stiffness or slowing of movement. In the early stages of Parkinson's disease, your face may show little or no expression. Your arms may not swing when you walk. Your speech may become soft or slurred.
  • Idiopathic Intracranial Hypertension Wikipedia
    Since then, shunting is recommended predominantly, with occasional exceptions. [5] [9] References [ edit ] ^ a b c d e f g h Wall, M (February 2017). "Update on Idiopathic Intracranial Hypertension" .
    TPTE2P6, TAS2R14, PRR4, RPH3AL, PARP4, TAS2R43, PRH1, LAMC2, FAM8A1, CXCR1, TULP3P1, CSF2, FOXN3, MOG, AQP4, LOC390714, SH3PXD2B, LOC102723407, LOC102724971, MINDY4, SERPINA3, SLC12A3, IGHV3-69-1, IGHV3OR16-7, RNU1-1, PTEN, SERPINF1, LAIR1, IL17A, HMGB1, ENO2, AQP1, LOC105379528
    • Idiopathic Intracranial Hypertension GARD
      Idiopathic intracranial hypertension (IIH) , formerly known as pseudotumor cerebri, is a condition that affects the brain. Pseudotumor cerebri literally translates to "false brain tumor." This term was used because symptoms of IIH resemble those of brain tumors depsite no tumor being present. Symptoms of IIH may include severe headache, nausea and vomiting, altered vision, and pulsating sounds within the head. A person with IIH may also have symptoms such as a stiff neck, back or arm pain, eye pain, and memory problems. If the condition remains untreated, permanent visual loss or blindness may develop.
    • Intracranial Hypertension, Idiopathic OMIM
      Buchheit et al. (1969) described 2 sisters with idiopathic intracranial hypertension with papilledema (pseudotumor cerebri). Traviesa et al. (1976) described 3 affected sisters. The patients are typically young females who are obese and may be pregnant or suffering from chronic dysfunctional uterine bleeding. Johnston and Morgan (1991) described a mother and 2 of 4 daughters who had a diagnosis of pseudotumor cerebri and 1 son who developed communicating hydrocephalus. Warner et al. (2002) quantified vitamin A in the cerebrospinal fluid of patients with idiopathic intracranial hypertension, elevated intracranial pressure of other causes, and normal intracranial pressure. Vitamin A could be detected by high-pressure liquid chromatography in most of the specimens.
    • Idiopathic Intracranial Hypertension Orphanet
      Idiopathic intracranial hypertension is a neurological disorder characterized by isolated increased intracranial pressure manifesting with recurrent and persistent headaches, nausea, vomiting, progressive and transient obstruction of the visual field, papilledema. Visual loss can be irreversible.
  • Systemic Scleroderma Wikipedia
    The colon can be involved, and can cause pseudo-obstruction or ischemic colitis . [5] Rarer complications include pneumatosis cystoides intestinalis , or gas pockets in the bowel wall, wide mouthed diverticula in the colon and esophagus , and liver fibrosis .
    IRF5, STAT4, CD247, TNIP1, PSORS1C1, CCN2, HLA-DQB1, COL1A2, CCN1, RHOB, SIRT1, HDAC5, S1PR5, SIRT7, PHF21A, XYLT2, ACTA2, NECTIN2, FOSL2, FBN1, FLI1, FSTL1, TGFBR1, CSF1, COL3A1, PTPN22, HLA-DPB1, PAH, TNFAIP3, BLK, DNASE1L3, PXK, ITGAM, NOTCH4, LMNA, WRN, JAZF1, TNPO3, LBR, IL12RB2, NFKB1, TYK2, KIAA0319L, SOX5, SMG7, CYP21A2, RNPC3, CRP, LINC01924, AVEN, RBM45, PRR12, VEGFA, PSORS1C2, DGKQ, CSK, IL13, ARHGAP31, ACE, EDN1, GSDMA, SAMD9L, DDX6, TPI1P2, TLR4, IL12RB1, IL10, IL6, IL4, TNF, IL17A, IL1B, IL1A, MSH5, IFNG, CDHR5, TNXB, NUP85, HSPA1L, NAB1, NCF2, HLA-DRB1, UROS, HLA-DRA, HLA-DQB2, HLA-DPA1, LRMDA, HFE, GRB10, GRB2, COL1A1, ZC3H10, CXCL8, MMP1, PHRF1, FN1, UROD, TIMP1, LINC00305, ANKS1A, MUC22, LEMD3, ATG5, TGFB1, IKZF2, AP4B1-AS1, HLA-DPA2, SLC29A3, POLD1, CCL2, GSDMB, SS18L1, AGER, SMAD3, MSH5-SAPCD1, ESYT1, STK19, ACR, IL12A-AS1, SLC12A3, PTPN11, LINC01500, CHRM5, CLCNKB, ICAM1, IFNA1, TOP1, CTLA4, IFNA13, FOXP3, CAV1, NOS3, BTG3, TNFSF13B, MMP9, HGF, PF4, HLA-DQA1, IL2, MMRN1, PPARG, CCL18, ACTB, CD19, CD226, MUC1, MIR21, MAPK1, MS4A1, IL22, KRT20, AIF1, ADIPOQ, CXCL10, HLA-C, SPARC, MMP2, IL33, MMP12, FAM167A, FLII, SMAD2, LGALS3, IL21, GEM, STAT3, AGT, DKK1, TSSK1B, IRAK1, TNC, FAS, POSTN, TGFBI, ENG, MIR29A, MIR155, CD40, BANK1, KIR3DL1, EGF, PLAU, BCL2, HIF1A, PSS, SMAD7, SFTPD, CD40LG, GRAP2, MAPK3, FGF2, TRIM21, DECR1, CDH11, VWF, CENPA, IGFBP3, TLR9, MAPK14, SELE, TNFSF14, AHSA1, CRK, AIMP2, GDF15, MMP3, CCL5, CD34, THBS1, HT, SERPINE1, CD28, CD22, KL, TSLP, FBL, POLDIP2, TNFSF4, RNF19A, FCGR3A, PLOD2, SELP, EXOSC10, AKT1, KIR2DS1, GSTK1, SELL, SLCO6A1, PTGS2, AGTR1, CENPB, IL18, CYCS, CXCR2, IL13RA1, IL2RA, PLG, PTPRC, TNFRSF14, CHI3L1, CXCL13, IL6ST, TRBV20OR9-2, CXCR4, NLRP3, TGFB2, CCL21, CXCL12, CCR7, POLR3A, HLA-A, HLA-B, EDNRA, ESR1, GATA3, IL23R, MUC5B, IRF7, TLR2, CEBPZ, SRF, SPP1, EGR1, HLA-G, MIF, IFNL1, GRN, MTOR, CD69, CD70, KIR2DS2, COL18A1, IL23A, DCN, SNRNP70, EGFR, TGFBR2, PTX3, CASP1, PDGFRB, MECP2, MET, TAP1, SMAD4, DDX19A, TAP2, MCAM, NAT2, TAL1, PRTN3, SERPINE2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PLAUR, SERPINF2, PMP22, HPGDS, SLPI, SERPINF1, RARRES2, REN, TSSK2, ROS1, S100A4, S100A7, S100A9, CCL7, CX3CL1, PI3, ICOS, MPO, NOS2, MPZ, TAGLN, GDE1, MYBL2, SCLY, SLC27A5, NFE2L2, NM, TLR8, TLR7, PDGFRA, EGFL7, TNFRSF11B, ADAMTS13, P4HB, IL21R, NOX4, RO60, TBX21, PDGFA, SRY, IRF8, EDNRB, GSTM1, COMP, CSF2, CTNNB1, DDX46, CYP2B6, CYP2D6, DNMT1, DPP4, LRPPRC, LOX, EPHB2, VDR, EZH2, PTK2B, PLD4, FCGR3B, FCN2, VCAM1, DBA2, IL17F, FOS, FOSB, ACKR1, GABPA, GPI, MIR126, CCR8, CCR6, BLM, TNFSF10, ADAM8, NR0B1, PDE5A, ALOX5, CCR2, AQP3, IKBKG, DHX16, ATM, BCL6, KLF5, CENPC, CD163, CASP3, SERPINH1, CD14, CD86, CD58, CD68, MIR196A1, FGF23, MIR150, CEL, CXCR3, SDC2, GSTT1, KRT7, IFN1@, IFNAR1, JUNB, TNNC1, TNFRSF1B, IGFBP5, IL1R1, KIR3DL2, IL1RN, SEMA4A, SMOC1, IL16, ISG20, ITGA5, TIMP2, KIR2DL2, ITGB2, THY1, KCNA5, JUN, JUND, RETN, KLK1, PARP9, HRAS, ATP8B4, HLA-DRB5, HAX1, TRAF6, ZBP1, LGALS9, LEP, WDR11, GZMA, TP53, TWIST1, GTF2I, COPB2, MSC, ASAP2, SLC33A1, ICOSLG, KLF4, CCL27, APLN, OSMR, EIF2S2, SMG1, KDM6B, UTP14A, PAPOLA, UTS2, EIF2B4, SPAG9, MBD4, ACSBG1, BICD2, EIF2B2, EIF2B5, PLCL2, TIMELESS, SLIT2, FHL5, UBE4A, PPIG, SUB1, TNFSF15, SPIN1, ZNRD2, EBI3, SEMA4D, RPP14, NXF1, LIAS, CDK2AP2, TAB1, ZMPSTE24, EMG1, SEMA3A, UBE4B, CDC42EP1, RNPS1, MAGI2, CNTRL, PLAA, NLRP1, TSIX, NID2, TUSC2, PDAP1, ACOT7, BMS1, TREX1, WIF1, ROCK2, RPP38, CXCL14, SEMA3E, MRPS30, DIABLO, SYNE1, CARD16, H4-16, IL34, LRRC34, SPAAR, HFM1, APOBEC3A, PRSS55, IFNL3, NANOS2, STING1, FCRL6, ACTBL2, LINC01193, DNAAF3, FAM111B, MMP21, CDCA5, MIR130B, PRRT2, SHCBP1, STN1, TRPM3, PDCD1LG2, SLC38A1, TLR10, FCRL4, LOXL4, NT5C1A, IL1F10, SPZ1, TUBA1C, HAVCR2, SYS1, INTS4, ENHO, MIR142, SIRT3, NCF1, MIR542, MIR618, TSPY3, POTEF, MIR708, C20orf181, CD24, TSPY10, MIR3606, OTUD6B-AS1, MIR5196, APOBEC3A_B, PGR-AS1, UPK3B, MTCO2P12, LGALS7B, POTEM, MIR145, MIR483, MIR146A, MIR17, MIR200C, MIR206, MIR26B, MIR30A, MIR17HG, POTEKP, MIR135B, MIR151A, PLF, KIR2DL5B, H4C15, MIR202, MIR193B, SUV39H2, NAA16, GGCT, IL17B, DLL1, TRBV28, TRBV20-1, TRBV3-1, LAMTOR2, FLVCR1, RGCC, SETD2, TBK1, TRPM5, IL19, EFEMP2, KLK12, DUOX2, MBL3P, RBMS3, BBC3, WNK1, DNAI1, CBX5, MMD, SEC14L2, RBFOX2, SMUG1, FAM215A, PLD3, IL17RA, POLR1A, TSKU, LRIT1, PRPF31, ERAL1, GREM1, HAVCR1, ASAP1, TAS2R13, SOST, TNFRSF12A, GOPC, CD248, SMURF1, MRTFA, SPG16, TRIB3, SCAF1, SIGIRR, TRPV4, RXFP1, FBRS, CHST8, GORASP1, SMURF2, IL25, PTLAH, DOK5, IL26, ROBO4, CSAD, OTUD6B, RTRAF, SF3B6, CD244, DUOX1, FBLIM1, IFT122, FAM20A, MTPAP, SLC47A1, CHRNA9, CARMIL1, HHAT, CDK5R1, CXCL5, NRP1, HLA-DMB, HLA-DPB2, HMGB1, HOXA9, HOXD13, HP, HPRT1, HSPA4, HSP90AA1, HSP90AB1, HSPG2, HTR2A, ICAM2, ID2, IFI16, IFIT1, IFNAR2, IGF1, HLA-DOA, HLA-DMA, IL2RB, HDC, FGF6, VEGFD, FKBP1A, FOXC1, FOXO3, FLNB, FLT1, FLT4, FOLR2, FPR2, GAB1, GCHFR, GLB1, GLI1, GSK3B, GYPA, HCL2, IL1RAP, IL3, MMP10, KIR2DS3, KNG1, KRAS, KRT1, LAG3, LGALS7, LIF, LIFR, LOXL2, LTA, SMAD1, MBD1, MBL2, CD46, MEFV, MFGE8, KITLG, MIP, KLRB1, KIR2DL3, IL6R, KDR, IL7R, IL9, IL10RB, IL11, IL12A, IL13RA2, TNFRSF9, IDO1, IRF4, ITGA2, ITGAL, ITGAV, ITGB3, ITGB5, ITGB8, JAK1, JAK2, FCGR2B, FCGR2A, F8, AQP1, ABCC6, RHOA, RHOC, ATF3, BGN, BMP6, BMPR2, BPI, BST2, CALCA, CAPG, CAST, CAT, RUNX3, CBL, CD1A, CD1D, AR, APOH, F2R, APOE, ABL1, ACACA, ACP3, ACTG1, ACTG2, ACVRL1, ADA, ADORA2A, PARP1, APLNR, ALB, ALDH3A2, ALOX5AP, ANGPT1, ANGPT2, ANXA1, AIRE, TNFRSF8, CD36, CD44, CD72, CYP1A1, CYP2C9, DDT, DLAT, DNAH5, ATN1, DSG2, HBEGF, ECE1, EDA, EGR2, EGR3, EIF2B1, ELANE, EP300, EPHA1, ETS1, CYBB, CYBA, CTSV, CHRM3, CDC42, CDH5, CDK5, CDK6, CDKN2A, CDSN, CENPE, CCR3, CTSG, LTB4R, CNR1, CNR2, CRYGD, CST3, CST4, NKX2-5, KMT2A, MMP14, NRP2, TBX1, TEK, TERC, TG, TIMP3, TIMP4, TLR3, TLR5, TM7SF2, TNFRSF1A, TPI1, TPO, CRISP2, TRPC1, TSHR, TSPY1, TTN, TNFRSF4, TRB, ADAM17, SUMO1, TAC1, SNAI2, SMN1, SMN2, SIGLEC1, SOAT1, SOD1, SOD3, SOX2, SP1, SPG7, SRPK2, SSB, STAT5A, STAT5B, STAT6, SULT1E1, SYT1, TXN, SCGB1A1, MNAT1, H4C11, H4C8, H4C2, H4C5, H4C13, H4C14, LTBP4, NR0B2, MMP23B, MMP23A, FCN3, USO1, RTCA, SSNA1, OASL, MBTPS1, TNFSF13, TNFRSF10B, H4C3, H4C12, EZR, H4C6, VIM, VIP, VIPR2, VTN, WNT1, WNT3, XRCC1, XRCC4, YY1, PTP4A1, EOS, ARHGEF5, CDR3, H4C9, AXIN2, H4C1, H4C4, SLC25A1, SLC11A1, SLC6A4, DDR2, OXCT1, P2RX7, PAK3, PAM, REG3A, PCBD1, PCM1, PDCD1, PDE4A, PDGFB, ENPP2, PGF, PGGT1B, PGM1, ABCB1, SERPINA1, PIK3C2B, OAS2, YBX1, ST3GAL1, NPPB, MS, MSN, MSR1, MT1G, MT3, COX2, MTHFR, MUC2, MX1, MYB, MYBPH, MYC, NDN, NFIC, NFIX, NOS1, NOTCH1, PLAT, POMC, PRKCA, PRKCB, S100A6, SCN9A, CCL17, CCL19, CCL24, CCL25, CXCL6, CXCL11, SERPINA3, XCL1, SDC1, SDHC, SELPLG, SFRP1, SFRP4, SFTPB, ST6GAL1, RXRB, RORC, ROCK1, PTBP1, PRKCD, PRKG1, MAP2K7, EIF2AK2, PRL, PRS, PSMB6, PTEN, RNASE3, PTGIR, PVR, PXN, RAC1, RAG2, RELA, RHCE, H3P8
    • Scleroderma, Familial Progressive OMIM
      Description Systemic sclerosis is a clinically heterogeneous connective tissue disorder characterized by immune activation, vascular damage, and fibrosis of the skin and major internal organs. Clinical and experimental data suggest that the disorder is multifactorial, involving both genetic and environmental factors (Fonseca et al., 2007). Gabrielli et al. (2009) provided a detailed review of scleroderma, including clinical manifestations and pathophysiology. See also Reynolds syndrome (613471), which shares some clinical features with scleroderma and CREST syndrome. Clinical Features Greger (1975) described 3 males, including father and son, with progressive systemic scleroderma (systemic sclerosis) in an inbred triracial isolate of southern Maryland, known as the Brandywine group.
    • Systemic Sclerosis Orphanet
      Systemic sclerosis (SSc) is a generalized disorder of small arteries, microvessels and connective tissue, characterized by fibrosis and vascular obliteration in the skin and organs, particularly the lungs, heart, and digestive tract. There are two main subsets of SSc: diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc) (see these terms). A third subset of SSc has also been observed, called limited Systemic Sclerosis (lSSc) or systemic sclerosis sine scleroderma (see these terms). Epidemiology The prevalence is estimated at about 1/6,500 adults. Women are predominantly affected (F/M sex ratio around 4:1). Clinical description The disease usually manifests between 40 and 50 years of age.
    • Systemic Scleroderma GARD
      Systemic scleroderma is an autoimmune disorder that affects the skin and internal organs. It is characterized by the buildup of scar tissue (fibrosis) in the skin and other organs. The fibrosis is caused by the body's production of too much collagen, which normally strengthens and supports connective tissues. The signs and symptoms of systemic scleroderma usually begin with episodes of Raynaud's phenomenon , which can occur weeks to years before fibrosis. This may be followed by puffy or swollen hands before the skin becomes thickened and hard.
  • Tetanus Wikipedia
    The "spatula test" is a clinical test for tetanus that involves touching the posterior pharyngeal wall with a soft-tipped instrument and observing the effect.
    ABO
    • Tetanus Mayo Clinic
      Overview Tetanus is a serious disease of the nervous system caused by a toxin-producing bacterium. The disease causes muscle contractions, particularly of your jaw and neck muscles. Tetanus is commonly known as lockjaw. Severe complications of tetanus can be life-threatening. There's no cure for tetanus. Treatment focuses on managing symptoms and complications until the effects of the tetanus toxin resolve. Because of the widespread use of vaccines, cases of tetanus are rare in the United States and other parts of the developed world.
    • Tetanus Orphanet
      A toxin-mediated infection due to the anaerobic bacteria Clostridium tetani and characterized by spasms and contractions of the skeletal muscles, the disease is often lethal. Epidemiology Tetanus has almost disappeared from countries where a vaccination policy is ensured and implemented. Annual incidence in developed countries is less than 1 / 1,000,000 inhabitants, and mainly affects patients over 70 years of age. The annual incidence is 100 to 200 times higher in the poorest countries. There are no international statistics on the number of adult cases. In 2015, the number of newborn deaths recorded was 34,000.
  • Bubonic Plague Wikipedia
    Common themes include the breakdown of society, institutions, and individuals during the plague, the cultural and psychological existential confrontation with mortality, and the allegorical use of the plague in reference to contemporary moral or spiritual questions. [ citation needed ] Biological warfare Some of the earliest instances of biological warfare were said to have been products of the plague, as armies of the 14th century were recorded catapulting diseased corpses over the walls of towns and villages to spread the pestilence.
    CCR5, IL1A, IL1B
  • Community-Acquired Pneumonia Wikipedia
    Palpating the chest as it expands and tapping the chest wall to identify dull, non-resonant areas can identify stiffness and fluid, signs of CAP.
    CRP, COPD, TNF, IL6, ACE, IL10, HMGB1, MBL2, MMP9, ALB, TLR4, ADM, LNPEP, IRF5, SFTPB, SERPINB6, IL1RN, SLC9A6, HACD1, GRN, SLC2A10, SORBS1, BRD4, CTAA1, ANGPT2, COL4A5, CAP1, AVP, DELEC1, SDC4, NLRP3, SFTPD, SMPD1, TIMP1, TLR9, FGF21, HAVCR1, VDR, ARHGEF5, BHLHE40, BECN1, TIMELESS, SAFB, RGS6, RTN3, CCL18, A2M, RASA1, RARB, AGTR1, AMBP, BAG1, CAMP, CFTR, CHI3L1, DDX3X, FCGR2A, FCN2, HSPA1A, HSPA1B, HSPA2, TNC, IL1B, IL4, CXCL8, IL13, LTA, MCL1, MEFV, MRC1, MUC1, MYLK, SERPINE1, PTX3, MIF
  • Gonorrhea Wikipedia
    Culture (growing colonies of bacteria in order to isolate and identify them) and Gram-stain (staining of bacterial cell walls to reveal morphology) can also be used to detect the presence of N. gonorrhoeae in all specimen types except urine. [30] [31] If Gram-negative, oxidase-positive diplococci are visualized on direct Gram stain of urethral pus (male genital infection), no further testing is needed to establish the diagnosis of gonorrhea infection. [32] [33] However, in the case of female infection direct Gram stain of cervical swabs is not useful because the N. gonorrhoeae organisms are less concentrated in these samples.
    ERBB2, BCL6, SULT2A1, ZAP70, NR3C1, BCL2, SPG21, IRF4, SPACA9, IL6, TLR4, IL10, CD274, MME, PWWP3A, TNF, CXCL8, CFH, NOD2, GKN1, ESR1, VOPP1, LEP, CTNNB1, MET, ABCB1, GPRASP1, CD163, MTA2, SDC1, TP53, MUC16, HOXA10, CDH1, CEACAM3, C4BPA, C4BPB, THEMIS, RD3, CIB2, CKAP5, ZEB2, MIR503, SCO2, HDAC6, MPZL2, NOD1, YAP1, MCRS1, POSTN, CIB1, ATG5, AHCYL1, ARPP21, HSPH1, PPARGC1A, MALT1, MIR489, MIR451A, CKAP4, MIR377, MIR33B, MIR589, MIR371A, VPS9D1-AS1, LOC107987479, TNFAIP3, CCAT2, TP73, TTR, TXN, TYMS, NNT-AS1, UMPS, UVRAG, VDAC1, VIP, XRCC1, MIR1298, MFT2, CUL4B, PPFIA3, TP63, BECN1, URI1, APLN, SQSTM1, SOCS3, PRDM4, SIRT1, GPR182, HAVCR2, IFIH1, FRTS1, FTO, FSD1, MIR195, MIR139, ARHGAP24, FSD1L, BRSK1, HDGFL2, MALAT1, NPVF, WDR20, SOX2-OT, CDCA5, CPXM2, GSC, RASSF6, MLKL, TIGIT, IL27, ADGRF1, MIR200C, TNMD, NID2, MIR224, TFAP2E, RAI14, MIR93, IL22, FOXP3, SOST, TMEM8B, IL17D, LZTFL1, MIR23B, MIR215, CPAT1, SARS2, KIF26B, FBXW7, TLR2, INTS13, MYDGF, MIR214, MIR21, SLC12A9, IL21, ABCA4, SPP1, TGFB2, ERBB4, CYP2D6, DPYD, ATN1, TSC22D3, E2F1, TYMP, EGF, EGFR, EGR1, EMP1, DMTN, ERBB3, ERCC2, CSF3R, FDPS, FES, FKBP5, FOXF1, FOXO1, FLT4, MSTN, GLI2, GNA12, GRN, HINT1, HLA-F, CYLD, CSF3, IFNG, FOXL2, ABO, ADM, ADRB2, AFP, AGER, AHR, AMH, KLK3, ATM, CCND1, CEACAM1, PRDM1, BRCA1, CCR4, CALCR, CAT, CCND2, CD40LG, CD44, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDX2, CEACAM5, CLU, HMGB1, IGF2, TGFB1, SARS1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PTCH1, PTH, PTGS2, MOK, RAP1B, RGS3, RPE65, RRM1, CXCL12, SLC26A4, SKP2, SLPI, SNAI2, ABL1, STAT3, TAZ, ZEB1, TRBV20OR9-2, TEAD4, TFF3, TFPI, TFRC, SERPINA1, FURIN, IL2, MATN1, IL15, IL16, IL17A, ILF2, INPPL1, INSRR, IRF1, IRF2, ITGAV, JUN, KIF2A, L1CAM, MAX, NPR2, CD46, MMP8, MMP9, ABCC1, MTHFR, MTRR, MUC4, MUTYH, MYC, NDUFAB1, NFE2L2, NME1, H3P10
    • Gonorrhea Mayo Clinic
      Overview Gonorrhea is a sexually transmitted infection (STI), also known as a sexually transmitted disease (STD). Gonorrhea is caused by a bacterium that infects both males and females. Gonorrhea most often affects the urethra, rectum or throat. In females, gonorrhea can also infect the cervix. Gonorrhea is most commonly spread during vaginal, oral or anal sex. But babies of infected mothers can be infected during childbirth. In babies, gonorrhea most commonly affects the eyes. Abstaining from sex, using a condom if you have sex and being in a mutually monogamous relationship are the best ways to prevent sexually transmitted infections.
  • Esophageal Cancer Wikipedia
    This involves the passing of a flexible tube with a light and camera down the esophagus and examining the wall, and is called an esophagogastroduodenoscopy .
    CDKN2A, EGFR, PTGS2, WWOX, TP53, LZTS1, DCC, RNF6, TGFBR2, ADH1B, ALDH2, CASP8, MIR21, ERBB2, BCL2, CCND1, MIR145, ABCB1, XIAP, PRDX1, RUNX3, MET, LGALS3, PRDX2, SOX2, MMP14, KDR, XRCC3, BAX, SOD2, SERPINB3, MIR200C, TPM1, CDH13, MLH3, NR1I2, WIF1, CXCL2, ABL1, ACTB, ZNF667-AS1, MARCHF8, ALOX15, SFN, MIR98, PTGS1, GAPDH, GNG7, TNFRSF10A, CCNH, UCHL1, TPM4, GRIK2, CYP19A1, CYP26A1, PHB, MAP3K3, TGM2, MT1G, SST, CSF3, NOS2, CRYAB, SNAI2, NOS3, TUFM, ENO1, AKAP13, SMYD2, SLC30A7, MACIR, BCL2A1, AQP3, RPRM, TRMT11, GHRL, BBC3, ADH7, MYC, IL5, CXCL1, MXI1, HMOX1, CTNNA1, PLCE1, STK11, MUC1, RHBDF2, SLC52A3, HLA-A, RUNX1, SLC39A6, ADH4, CHEK2, PCAT1, ERCC1, FKBP1A, MGMT, FLACC1, PEBP4, TMC1, MTHFR, LINC01504, MTAP, CCDC63, DGKH, GSTM1, SDCBP2-AS1, TSPAN11, STEAP1B, MCC, HECTD4, KIT, TEX41, IL6, LINC01405, OCA2, PLCE1-AS1, SLC25A24P1, GSTT1, GSTP1, JAZF1, PIK3CD, PDE4D, TBL2, TFDP1, HEATR3, SEMA5B, TNF, TRPC4, CD274, XBP1, ZFAND5, STAT3, CUBN, SMUG1, IL18R1, PES1, SMG6, KANK1, IKZF3, ABCC8, SREBF2, PDGFRA, PTPN2, SGF29, PIK3CA, PIK3CB, PIK3CG, MAPK1, PTEN, AGBL4, SPINK7, ACAD10, ST6GAL2, SDHA, SDHB, SDHC, ST6GAL1, FAM167A-AS1, FAM167A, VEGFA, H3P10, CYP2E1, AKT1, CDH17, AMPH, CLN3, CRP, CSNK1A1, CTNNB1, AHR, CYP1A1, CALR, CALCR, MDM2, CEACAM5, SLC6A8, HIF1A, TGFB1, NQO1, MIR203A, COX2, EGF, EPHX1, CDKN1A, APC, XRCC1, IGF1, VEGFC, AKR1A1, EPHB2, FHIT, PRM3, MIR34A, RAD51, RARB, IL10, UCA1, TERT, MIR375, IGF2, MMP2, TP73, MTCO2P12, GLI1, CXCR4, PPARG, CCK, EPCAM, MMP7, BMI1, IGFBP3, PCNA, RASSF1, HPSE, OGG1, DNMT1, TMPRSS11A, HPGDS, ECRG4, YAP1, SLC12A9, CDH1, TWIST1, BSG, NAT2, FGF2, EZH2, EGR1, DPYD, IGF1R, ARHGAP24, E2F1, CDK2, MMP9, AURKA, MALAT1, PDCD4, COMMD3-BMI1, BRCA2, FAS, IL1B, MIR93, MIR143, IL18, CDKN2B, TLR4, CKAP4, S100A4, MAPK3, KRAS, FOXA1, PDPK1, ERCC2, ALB, TP63, TNFSF10, ALDH1A1, IFNG, SOX4, PROX1, BHLHE40, CTAG1A, IL1RN, CST3, SOX17, CXCL8, AVP, TYMS, SLCO6A1, CTAG1B, IDO1, VDR, GSTK1, CASP3, BAGE4, PRKCI, CTTN, MIR141, CASC9, PDK1, GNAS, ATAD1, AR, LATS2, MIR139, ADH1C, LOXL2, CDK4, ZNRD1, MIR10B, DELEC1, PLCL1, ABCG2, HMGB1, CYP2A6, LINC01194, MIR214, TERC, CDKN1B, MIR155, ORAI1, PLK1, CXCL12, SERPINB4, CEACAM3, F2RL1, BIRC5, FOXQ1, NKD2, SKIL, CDKN3, SKP2, FASLG, CCNB1, IL27, IL23R, PRKAA2, LGMN, MIRLET7C, MIR100, MIR107, PRKCA, PRKAB1, PRKAA1, PSMB8, POU5F1, POLR2E, POLB, PLAU, MIR144, PKM, PSG2, PTK2, PAQR3, CEACAM7, ANXA2, RPS6KB1, ANXA1, ANGPT1, RPE65, DACT2, RNF2, PTK7, REG1A, RBBP6, RB1, FAP, RARA, SLC39A5, HAVCR2, CDC34, SOX9, ZEB2, CTAG2, CRNN, GEMIN4, CLOCK, KLF4, PTTG1, MTA1, BCL2L1, IL17D, HSPB3, BAG1, SPHK1, RUNX2, KAT2B, PROM1, CCN4, UGT1A1, IST1, BRCA1, SPP1, NXT1, NLRP1, RIPK3, DKK1, RAB40B, SUB1, TBC1D9, ENG, SIRT1, MRPL28, SNHG1, NDRG1, TUBB3, PSMD14, BUB1B, UBE2S, CHAF1A, FRAT1, ERBB4, TNFRSF10B, FEV, LY6K, ANKRD36B, EIF4EBP1, GAS5, TTK, TRAF6, BHLHE41, TP53BP1, CDC25B, TNFAIP3, ZC3H12A, TGM3, PDCD1LG2, CLPTM1L, EIF4E, CDK6, AFAP1-AS1, SRC, UNG, UVRAG, CD38, FERMT1, AXL, ZNF654, FBXW7, AXIN2, MEG3, ADAM12, TUSC3, TENM3, WNT1, MYDGF, DIABLO, XRCC4, EYA4, XK, CD34, TP73-AS1, PIN1, SATB1, MIR146A, MIR29C, IL17A, CXCL10, IRF2, MIR148A, JUN, JUNB, JUND, POU5F1P4, POU5F1P3, KRT16, MIR483, MIR193B, SMAD4, MIR451A, MAGEA3, MAL, CTSB, MDK, MKI67, MLH1, MIR377, ABCC1, MSH2, FGF13, MIR301A, MIR576, IL12B, CXCR2, HGF, H3P9, GJB2, GML, GRB7, CCAT2, FALEC, GSN, GSTM2, GSTM3, H2AX, HDAC1, MTOR, IL2, UBE2K, ADAMTS9-AS2, CD24, HRAS, HSPB1, HSPB2, HSP90AA1, HOTAIR, FOSB, FOS, IL1A, MAPK14, SNORD116@, CASP10, MIR199A1, MIR199A2, MIR183, PEBP1, ODC1, NQO2, CRYZ, FGF7, NRDC, MIR27A, FBXL19, UGT1A8, MIR200A, GAEC1, DLL4, AKT2, MIR20A, MIR873, MARCHF5, OTUD4, MIR122, MIR543, CRCT1, KRT20, TLR9, PARP1, SIRT6, NT5C3A, SLC25A37, DACT1, LINC00184, CHST15, ZMYND10, UBR5, IL23A, SYCE1L, MIR1294, ELK1, MIR126, SPA17, ADAR, XAF1, NANS, TDRG1, FBLIM1, NBAT1, CT47A4, SAGE1, SOX6, MIR206, OTUB1, DSG3, CT47A5, MFN1, CT47A6, CHFR, ACSS2, CT47A8, ERBIN, CT47A9, STK31, CT47A10, MIR210, BDH2, ZNF331, TMEM176A, HULC, LAPTM4B, ACP6, TRIM44, RNF111, SYTL2, MAGED4, TUG1, CT47A1, MIR204, SLC52A1, ANO1, SBNO1, NAT10, QRSL1, MIR205, CT47A2, CHDH, CT47A3, IGF2-AS, LINC01234, PANTR1, BNIP3, CSAG2, SEMA3B-AS1, LINC01617, KCNH4, SLC44A1, ANGPTL2, SLC25A20, SEC14L2, PADI4, CA2, MIR186, PLA2G15, TMEFF2, C4BPA, LINC-ROR, MIR187, PRDX5, MPRIP, CERNA3, PEG10, SBNO2, OIP5, RRAS2, CASP1, PUF60, H3P17, ZHX2, MIR150, MMRN1, MIR16-2, RAB3GAP1, MIR152, TPX2, TPM1-AS, DNMT3B, KDM1A, SMG1, RNF19A, MTHFD1L, POLDIP2, IL22, MIR197, PSAT1, CT47A12, MIR129-2, MIR198, STOML2, MIR127, CYHR1, MIR140, CCAT1, DDX11-AS1, F11R, FOXP3, NDUFA13, LEF1, ATP6V0C, HOOK2, ACTA2, ZBTB20, EMP3, RGS22, PHGDH, NKX2-8, ABO, DNM3OS, MIR550A3, PABPC1, LAMP3, DROSHA, MIR192, IL37, RPL17-C18orf32, EMP1, MIR196A1, MIR196A2, ACACA, C1GALT1, MIR296, ELANE, RHOXF2, MIR423, TSPAN18, EMILIN3, ABCB5, DHCR24, WDR20, MIR382, FFAR4, MTDH, SCGB3A1, NAF1, MIR361, PRRT2, MIR374A, MIR373, FBXO32, APEX1, TSLP, DUXAP8, BAGE3, PWAR4, MIR494, ARG1, MIR202, MIR146B, ACCS, CCDC54, MIR491, RIOX2, DUXAP10, SOX2-OT, MIR433, VSIG1, AQP4, MIR20B, MIR363, SNHG7, MIR372, KLF17, OSR1, JMJD1C, ZFP82, ATN1, MIR96, ADAMTS16, MIR34B, DSC2, MIR31, ALOX15B, CBLL2, FOXK1, MIR30E, MIR30B, MIR302A, CT47A11, ALOX5, MIR24-1, MIR17HG, LRATD2, EPHA2, LINC00261, KCNH8, MIR340, CKS1BP7, CTCFL, TMED10P1, RPL34-AS1, MIR339, OR2AG1, AGER, DACT3, ANXA7, MIR338, PDIK1L, MIR335, MIR326, MIR302B, LINC-PINT, MIR498, CRISP1, MIR499A, USP28, KIAA1522, MIR574, SUGP1, MIR556, IL21, RERE, ZNF667, MIR219A1, GOLPH3, MIR542, MIR539, GORASP1, CDCP1, MARCKSL1, RSRC2, VLDLR-AS1, MIR212, KLHL1, MIB1, SLC44A2, ADAMTS9, IS1, ACKR3, MIR655, AKR1B10, MIRLET7G, CYSLTR2, MIR625, POTEG, MIR601, DANCR, S100A14, NDRG2, TENM2, INTS2, MIR593, WNK1, TRPM8, FSD1, MIR506, MIR487A, ZFHX3, MIR486-1, MAGED4B, NECTIN4, TSC22D4, MIR224, MIR502, ALPK1, ARSA, ARNTL, CRISPLD2, USP26, FSD1L, PHF6, SARNP, WNT10A, RNF34, ALCAM, VTCN1, MUL1, CT47A7, FAT4, DPP4, MIR221, ATM, NEIL1, LIN28A, CSAG3, FBXO31, RASSF10, NANOG, WLS, GRHL2, NAA25, C17orf97, SSX2B, XRCC6, CAV1, PDHA1, CDK14, PGD, PGF, COL11A2, COL6A3, CNTN1, CNR1, PIM1, ABCC2, LTB4R, PLA2G2A, PLG, PRRX1, PON3, POR, POU2F1, POU5F1B, PPL, PRKCB, CCR5, MAPK8, MAP2K1, MAP2K3, PECAM1, PDGFRB, MAP2K7, CLDN4, TRIM37, CSF2, MYD88, GADD45B, NF2, NGF, NOTCH1, NPAS2, CRMP1, FGF4, SLC22A18, CRK, PAH, SERPINE1, PRKN, PAWR, PAX2, PBX1, FGF3, PCYT1A, PDCD1, PDE4A, CREB1, MAP2K6, EIF2AK2, FGF12, RMRP, RPA1, RPL15, RPL17, RPL34, RPN2, RRAD, RRAS, S100A9, SAFB, SALL2, SAI1, TSPAN31, SAT1, CCL1, CCL2, CCL11, CCL15, CCL18, CCL20, CXCL11, CFTR, CEBPB, F3, ABCE1, RIT1, HTRA1, RELB, KLK10, PSMB9, PSMD4, PTCH1, FEN1, CKS1B, CHRNA3, CHGA, PTPN6, PVT1, RAC1, RAC3, RAD9A, RAD23B, FASN, RAF1, RAP1A, RARRES2, RBL2, RBM3, RBM4, RBP2, RELA, MUC4, MTR, DDX5, FOXA2, HOXA1, HOXA9, HOXA13, HOXD13, HP, HPGD, ERAS, HSPG2, ICAM1, ICAM2, ICAM3, ID1, IFNB1, IFNGR1, IGFBP1, FLT1, CCN1, IL3, CYP1B1, FLNB, IL7R, IL9, FOXO1, FOXA3, HLA-G, IL12A, HLA-DRB1, GAS6, GJA1, G6PD, GLI2, GNA12, DCK, DAPK1, GPR39, GRN, DAP, NR3C1, DACH1, DAB2, GRP, GSK3B, GSR, CYP24A1, FZD2, CYP2C9, HDGF, CYP2C19, HLA-DOA, HLA-DQA1, IL11, IL12RB1, MTTP, MCM7, FOXC1, CTNNA2, MFGE8, CCN2, MAP3K11, MMP1, ACE, FGFR4, MMP10, MMP13, CTBP2, MPO, MSH3, MSI1, MST1, MT1E, MT2A, MT3, CSTA, CYTB, MTHFD1, ND4, ND5, FOXC2, SMAD7, IL13, SMAD5, IL15, IL15RA, PDX1, ITGA6, IVL, JAK1, JAK2, CYLD, CXADR, KRT1, KRT7, KRT10, KRT19, STMN1, CTSL, LGALS9, LLGL2, LLGL1, LMX1B, LOX, TM4SF1, FOXM1, MAD2L1, SEL1L, SHH, SHMT2, F2RL3, GPRC5A, PIAS2, CLDN1, CCNE2, DCLK1, AURKB, NOLC1, RAB11B, IL32, NOG, MSC, UBE2L6, DCN, GRAP2, MAP4K4, MAGED1, PTGES, CHD1L, AKAP12, ISG15, MDC1, PCLAF, RASSF2, MAP3K14, LIMD1, BMS1, BCL10, LTBP4, RECK, CUL4A, CUL2, PPM1D, IFITM1, STC2, USO1, AKR1C3, BECN1, URI1, RIPK1, TNFRSF14, TNFRSF6B, TNFRSF11A, SCEL, GADD45A, BANF1, NRP1, CCN5, HDAC3, CDK5R1, PER2, EIF4A3, MAML1, CDX2, NXF1, ARL6IP5, AHSA1, TXNIP, PDPN, POSTN, CELF1, PTGES3, HSPH1, EPHA3, JTB, GADD45G, FASTK, BTG3, MLLT11, TMED10, FERMT2, KCNQ1OT1, SPINK5, IL24, CNMD, CD160, FSTL1, CAV2, CIB1, DDIT3, SPATA2, RAPGEF3, FARP2, RBX1, HDAC6, PDCD6, PARP2, DNAJB6, ABCB6, DNM1L, TSPAN1, ARL4C, TRAP1, ARFRP1, G3BP1, GDF11, TRIB1, MSLN, AKAP8, BCAS2, APC2, PAK4, TNIP1, ERBB3, RACK1, FZD7, BAP1, AXIN1, TCF4, ZEB1, TCF21, TRBV20OR9-2, TDO2, TERF1, EVPL, CDH3, TGFA, ETV1, TGFBI, TGFBR1, ETS1, CDC42, THRB, THY1, TIMP1, TIMP2, TLE2, TSPAN7, TSPAN8, TM7SF2, TMPO, TMSB4X, TCF7L2, TAP1, TAM, TAGLN, SIX1, SIX3, SLC1A5, SLC3A2, SLC11A1, SLC22A1, SMARCA2, SMARCA4, SIGLEC1, SNAI1, SNCA, SNCG, FSCN1, SOAT1, CDKN1C, SPRR3, SSR1, F2R, SSX2, STAT1, STC1, SULT1A1, SYT1, TOP1, ERCC5, CDC25A, TPM2, WRN, XIST, XPC, CD80, XRCC5, YES1, YES1P1, PCGF2, ZBTB17, ZNF208, CD3E, PRDM2, IL1R2, MANF, USP7, ST8SIA4, AIMP2, TFPI2, CCNG2, HMGA2, SLC7A5, MIA, NRIP1, WNT2B, WNT10B, VRK1, CD59, CDC20, TPT1, TRH, CD63, TRPC6, TSC1, ABCA4, ERCC4, UBE2D3, UBE2E2, UCP1, VIM, SLC35A2, UGT1A, UGT2B4, UMOD, UMPS, USP4, NR1H2, ERCC3, VHL, EZR, MAPKAPK2
    • Carcinoma Of Esophagus Orphanet
      Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). Epidemiology The estimated annual incidence of EC in Europe is approximately 1/13,300. Clinical description The disease usually presents between the ages of 50-70 years. It is often asymptomatic until it has reached an advanced disease stage with the first symptoms usually being difficulty in swallowing (dysphagia), especially present when swallowing dry foods. Unintentional weight loss is also common. Manifestations of back or chest pain, hoarseness of voice, unexplained coughing, protracted hiccups, and severe reflux may be presenting or associated symptoms.
    • Esophageal Cancer Mayo Clinic
      Overview Esophageal cancer is cancer that occurs in the esophagus — a long, hollow tube that runs from your throat to your stomach. Your esophagus helps move the food you swallow from the back of your throat to your stomach to be digested. Esophageal cancer usually begins in the cells that line the inside of the esophagus. Esophageal cancer can occur anywhere along the esophagus. More men than women get esophageal cancer. Esophageal cancer is the sixth most common cause of cancer deaths worldwide.
  • Guillain–barré Syndrome Wikipedia
    The key four gangliosides against which antibodies have been described are GM1 , GD1a, GT1a, and GQ1b, with different anti-ganglioside antibodies being associated with particular features; for instance, GQ1b antibodies have been linked with Miller Fisher variant GBS and related forms including Bickerstaff encephalitis. [8] The production of these antibodies after an infection probably is the result of molecular mimicry , where the immune system is reacting to microbial substances, but the resultant antibodies also react with substances occurring naturally in the body. [8] [24] After a Campylobacter infection, the body produces antibodies of the IgA class; only a small proportion of people also produce IgG antibodies against bacterial substance cell wall substances (e.g. lipooligosaccharides ) that crossreact with human nerve cell gangliosides.
    PMP22, CD86, AIRE, TNF, IL17A, CSF2, LAMC2, CD1E, ALB, CD1A, HLA-DQB1, IL1B, CD1C, TLR4, IL10, CD1B, ICAM1, IL23A, ISG20, FCGR2A, CRP, IL4, IL2RA, IL17D, HLA-DRB1, IL6, MAPK1, NFASC, GFAP, ITGAM, COX2, MYDGF, PTGS2, FCGR3A, APOE, IL27, FAS, MTCO2P12, CNTNAP1, YY1, YWHAZ, CXCR4, AIMP2, RETN, SELENBP1, TNFRSF1B, MIR155, GRAP2, GLDN, NOD1, VIM, MIR642B, SIGLEC14, AHSA1, OCLN, TLR2, TH, TGFB1, STAT3, SPP1, SMPD2, CXCL6, CCL2, PTPN11, MIF-AS1, IVNS1ABP, CSGALNACT1, POLDIP2, SMPD3, NS2, IL21, ISYNA1, FOXP3, IL22, ICOS, DLL1, ERVK-6, SIGLEC9, ST6GALNAC4, PTGS1, RNF19A, TUBGCP2, NOD2, SUMF2, FTSJ1, IL33, CADM1, FCRL3, FTSJ3, RBM45, HT, CABIN1, PLB1, YWHAQ, SIGLEC7, NOS2, PSMB6, F2R, HMGB1, HLA-DQB2, HLA-DQA1, HLA-DOA, CXCL2, CXCL1, NR3C1, GOLGA4, GNAO1, GLO1, GJB1, GALE, FOLH1, FCGR3B, ESR1, HPRT1, EPHB2, ENO2, CST3, MAPK14, CRK, COX8A, CNTN1, CDC42, CD59, CD80, CD14, CACNA1A, SERPING1, FASLG, HP, HSPA4, MAP2K7, MMP2, MAPK8, PRKD1, POMC, PLA2G1B, PKD1, PGF, PDCD1, NPPB, NPY, NOS3, NEFL, COX1, MRC1, MMP9, NR3C2, HSPD1, MIF, MBL2, LEP, ITGB2, ITGAL, IRF6, INSRR, CXCL10, IL18, IL12B, IL12A, IL2, IGHG3, IFNG, ERVK-32
    • Guillain-Barré Syndrome Orphanet
      A clinically heterogeneous spectrum of rare post-infectious neuropathies that usually occur in otherwise healthy patients and encompasses acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), Miller-Fisher syndrome (MFS) and some other regional variants. Epidemiology The overall annual incidence of GBS varies between 1/91,000 and 1/55,000. In Europe and North America, AIDP is the most frequent form of GBS (accounting for around 90% of cases) and thus the term GBS in general is synonymous with AIDP in Western countries. The axonal forms account for only 3-5% of cases in Western countries but are much more frequent (30%-50% of GBS cases) in Asia and Latin America. Etiology In the majority of cases, an infectious disease precedes the onset of limb weakness with Campylobacter jejuni infection being the most frequently identified initiating event.
    • Guillain-Barre Syndrome GARD
      Guillain-Barré syndrome (GBS) is a rare syndrome in which the body’s immune system attacks part of the peripheral nervous system . The peripheral nervous system carries signals from the brain to the muscles. Symptoms of GBS include muscle weakness, numbness, and tingling sensations, which can increase in intensity until the muscles cannot be used at all ( paralysis ). The exact cause of Guillain-Barré syndrome is unknown. In most cases, GBS occurs a few days or weeks after symptoms of a viral infection. In rare cases, GBS may run in families. A diagnosis of GBS is suspected when a person has symptoms suggestive of the syndrome.
    • Guillain-Barre Syndrome Mayo Clinic
      Overview Guillain-Barre (gee-YAH-buh-RAY) syndrome is a rare disorder in which your body's immune system attacks your nerves. Weakness and tingling in your hands and feet are usually the first symptoms. These sensations can quickly spread, eventually paralyzing your whole body. In its most severe form Guillain-Barre syndrome is a medical emergency. Most people with the condition must be hospitalized to receive treatment.
  • Immune Thrombocytopenic Purpura Wikipedia
    This is because the underlying autoimmune mechanism that is destroying the patient's platelets will also destroy donor platelets, and so platelet transfusions are not considered a long-term treatment option. [ citation needed ] H. pylori eradication [ edit ] In adults, particularly those living in areas with a high prevalence of Helicobacter pylori (which normally inhabits the stomach wall and has been associated with peptic ulcers ), identification and treatment of this infection has been shown to improve platelet counts in a third of patients.
    FCGR2C, ADAMTS13, CTLA4, MS4A1, FOXP3, CD19, ICOS, TNFRSF13B, STAT3, FAS, STAT1, TNFRSF13C, KRAS, TPP2, KMT2D, GALC, RFXANK, ZAP70, KDM6A, FCGR2A, TNFSF12, ARHGEF1, RASGRP1, RFX5, THPO, TPO, IL4, CIITA, MPL, IL10, NFKB1, IL7R, NFKB2, PNP, TNF, NRAS, PRKCD, IFNG, ACP5, RFXAP, SMPD1, CR2, FCGR3A, ITGA2B, ADA, CASP10, CD81, FASLG, IL2, TNFSF13B, IL18, IL17A, IL1B, IL22, IL21, DNMT3B, IL6, FCGR2B, TGFB1, HLA-DRB1, ITGB3, HAVCR2, LTA, IL17D, ISG20, ABCB1, GP1BA, CD86, IL17F, IL1RN, CD40, FCGRT, KRT20, IL27, IL2RA, IL11, CXCL12, SELP, RBM45, HT, NCAM1, PRB2, HPSE, HLA-A, CD40LG, NR3C1, GP9, MSC, FCGR1A, GP6, SYK, FCGR1B, IL18BP, GATA3, CD72, CD274, CSF2, CXCR4, PTPN22, ACSBG1, IL37, LEP, KIR2DS2, KIR3DL2, KIR3DL1, CXCL13, KIR2DL2, MIR146A, NOTCH1, MBD4, IL23R, IGHV3-69-1, IGHJ4, TNFSF13, NLRP3, PDCD1, VWF, IL33, PTEN, RAPH1, CCL2, IL23A, MYDGF, ABO, TNFRSF17, FCGR3B, CD44, IL1A, CD47, APOH, CXCR3, GATA2, CD69, CDKN2B, HES1, HOXD13, GZMB, GEM, CNR2, CRP, CD34, HLA-DOA, DNMT3A, CXCL10, CD38, RUNX3, TRDV3, TRDV2, RUNX1, CLEC1B, TRDV1, CD28, TBX21, NXT1, PYCARD, ENTPD1, MBL3P, DLL1, JAK2, IGHV3OR16-7, IGHJ6, CCR6, OPTN, TSHZ1, TCIRG1, IKZF1, SEMA4D, ATG7, ANP32B, MRPL28, CXCR6, CCR5, IGHV4-28, MALT1, SUB1, CCR3, CUL9, TBC1D9, CD70, HAVCR1, CD68, CASP3, RTEL1, MEG3, CAMP, TRIT1, MIR212, MIR221, MIR33A, MIR99A, MIR382, MIR409, ADAM10, MIR92B, CARMN, CCR2, MIR765, ACTN1, MIR1185-2, MIR3162, MIR3125, MICA, COMMD3-BMI1, IFNG-AS1, LOC102723407, GATD3B, LOC102724971, UPK3B, MTCO2P12, MIR200C, MIR195, MIR183, BCL2, SCAMP2, BMI1, CXCL16, CXCR5, HPSE2, CARD9, BID, GGCT, TRPM8, BCL6, CDCA5, ADRB3, STS, AR, DNMT3AP1, ANXA1, AHCY, JAG1, MIR106B, MIR125A, MIR130A, MIR142, CX3CR1, F2RL3, SCAMP1, MAPK1, NELL1, CXCL8, IL5, IL4R, NOTCH2, IL2RB, IL1R1, SERPINE1, IKBKB, IGH, MAPK8, SELE, IFNB1, PTGS1, PTGS2, PTPRC, RHD, ROS1, S100A8, HOXB4, CCL11, CCL18, IL9, NAP1L1, MYH9, COX2, KIR2DL3, KIR2DS1, KIR2DS3, KIR2DS5, IRF4, INSRR, KLRD1, IDO1, LGALS9, IL16, SMAD7, MAP6, MBL2, MDM2, IL12A, MIF, MMP9, MNAT1, IL10RA, MRC1, COX1, HOXA5, HLA-DRB3, CD83, FCN2, GATA4, RNF112, FKBP5, EOS, ARHGEF5, FGF2, CDR3, GATD3A, GFI1B, IKBKG, FCER1G, SIAH2, NRP1, CDK5R1, VNN1, TIMELESS, BCL10, EPHB2, MBD2, ITGA2, DECR1, DDX5, VEGFA, VDR, GCHFR, TNFRSF4, SLC7A4, HLA-DPB1, TRIM21, RO60, HLA-B, STAT4, HIF1A, TBXT, TRBV20OR9-2, TRGV1, TRGV2, TG, THBD, GRN, TIMP3, TLR4, TNFAIP3, TP53, GP5, TRAF6, TNFSF4, H3P9
    • Thrombocytopenic Purpura, Autoimmune OMIM
      Description Autoimmune thrombocytopenic purpura is characterized by a low platelet count, normal bone marrow, and the absence of other causes of thrombocytopenia. It is principally a disorder of increased platelet destruction mediated by autoantibodies to platelet-membrane antigens (George et al., 1994). Clinical Features In children, AITP is usually acute and self-limited, whereas in adults, it is most often chronic. The presenting features are bruising, petechiae, and/or mucosal bleeding (epistaxis, hematuria, and rarely intracerebral hemorrhage) (George et al., 1994). Cines and Blanchette (2002) and Imbach et al. (2002) provided comprehensive reviews.
    • Immune Thrombocytopenia MedlinePlus
      Immune thrombocytopenia is a disorder characterized by a blood abnormality called thrombocytopenia, which is a shortage of blood cells called platelets that are needed for normal blood clotting. Affected individuals can develop red or purple spots on the skin caused by bleeding just under the skin's surface. Small spots of bleeding under the skin are called purpura and larger spots are called ecchymoses. People with immune thrombocytopenia can have significant bleeding episodes, such as nose bleeds (epistaxis) or bleeding in the moist lining (mucosae) of the mouth. In severe cases, individuals may have gastrointestinal bleeding or blood in the urine or stool, or heavy and prolonged menstrual bleeding (menorrhagia).
    • Immune Thrombocytopenia Orphanet
      A rare autoimmune coagulation disorder characterized by isolated thrombocytopenia (a platelet count <100,000/microL), in the absence of any underlying disorder that may be associated with thrombocytopenia. Epidemiology The annual incidence is estimated at between 1/25,600-37,000 in Europe, with a female to male ratio of 1.3:1. Although immune thrombocytopenia (ITP) can occur at any age, incidence shows an age-specific bimodal distribution for men with two incidence peaks observed in boys (under 18 years old) and among those older than 60 years of age. Clinical description ITP exposes to a risk of bleeding. It is defined as severe when the presence of bleeding symptoms at presentation is sufficient to warrant treatment or when the occurrence of new bleeding symptoms requires additional therapeutic intervention. It is asymptomatic in one-third of cases. Mucocutaneous hemorrhage with purpura is the most frequent clinical manifestation, usually occurring when the platelet count is below 30,000/microL.
    • Idiopathic Thrombocytopenic Purpura GARD
      Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder characterized by too few platelets in the blood. This is because platelets are being destroyed by the immune system. Symptoms may include bruising, nosebleed or bleeding in the mouth, bleeding into the skin, and abnormally heavy menstruation . With treatment, the chance of remission (a symptom-free period) is good. Rarely, ITP may become a chronic ailment in adults and reappear, even after remission.
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