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Hiv/aids In Indonesia
Wikipedia
Historically the highest concentration areas have been Papua , Jakarta , East Java , West Java , Bali and Riau . [7] The island of Java, which includes the capital Jakarta, is now home to the highest concentration of HIV cases in Indonesia. Of the 34 provinces spread across the vast territories of Indonesia, two provinces represent more than a quarter (28%) of the national total of people living with HIV – DKI Jakarta and Papua ( [8] A generalised epidemic was already under way in the provinces of Papua and West Papua , where a population-based survey found an adult-prevalence rate of 2.4% in 2006. ... According to the Indonesian Ministry of Health, surveys reported that more than 40% of injecting drug users in Jakarta tested positive for HIV, and about 13% tested positive in West Java . ... Retrieved 17 April 2018 . ^ "Hapless Trade Minister Rahmat Scorned After Saying Used Clothes Transmit HIV - Jakarta Globe" . Jakartaglobe.beritasatu.com . 4 February 2015 . Retrieved 17 April 2018 . ^ "Sex education must be taught in schools: Child protection commission" . The Jakarta Post . Retrieved 17 April 2018 . ^ Schonhardt, Sara (17 April 2018).
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Passive–aggressive Personality Disorder
Wikipedia
Murphy and Loriann Oberlin . [4] Alternatively individuals may simply have difficulty being as directly aggressive or assertive as others. Martin Kantor suggests three areas that contribute to passive–aggressive anger in individuals: conflicts about dependency, control, and competition, and that a person may be termed passive–aggressive if they behave so to few people on most occasions. [5] Murphy and Oberlin also see passive aggression as part of a larger umbrella of hidden anger stemming from ten traits of the angry child or adult. ... (no longer a valid diagnosis in DSM) Treatment [ edit ] Psychiatrist Kantor suggests a treatment approach using psychodynamic , supportive , cognitive , behavioral and interpersonal therapeutic methods. ... Psychiatry , 56 (7): 600–06, doi : 10.1001/archpsyc.56.7.600 , PMID 10401504 ^ Tim, Murphy; Hoff Oberlin, Loriann (2005), Overcoming passive aggression: how to stop hidden anger from spoiling your relationships, career and happiness , New York: Marlowe & Company, p. 48, ISBN 978-1-56924-361-9 , retrieved April 27, 2010 ^ Kantor 2002 , pp. xvi–xvii, 5. ^ Tim, Murphy; Hoff Oberlin, Loriann (2005). [ page needed ] ^ a b "Disorders of adult personality and behaviour (F60–F69). ... CS1 maint: multiple names: authors list ( link ) ^ Kantor 2002 , p. 115. ^ Lane, C (1 February 2009), "The Surprising History of Passive–aggressive Personality Disorder" (PDF) , Theory & Psychology , 19 (1): 55–70, CiteSeerX 10.1.1.532.5027 , doi : 10.1177/0959354308101419 , S2CID 147019317 , archived (PDF) from the original on 2017-09-23 , retrieved 2017-12-06 Bibliography [ edit ] Kantor, Martin (2002), Passive-aggression: a guide for the therapist, the patient and the victim , Westport, CT: Praeger Publishers , ISBN 978-0-275-97422-0 , retrieved December 6, 2017 .
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Cerebral Creatine Deficiency
Wikipedia
Amino Acids . 40 (5): 1315–1324. doi : 10.1007/s00726-011-0852-z . PMID 21390529 . ^ a b c Schulze, Andreas (2009).
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Doping At The Asian Games
Wikipedia
Contents 1 Asian Games 1.1 1974 Tehran 1.2 1994 Hiroshima 1.3 1998 Bangkok 1.4 2002 Busan 1.5 2006 Doha 1.6 2010 Guangzhou 1.7 2014 Incheon 1.8 2018 Jakarta–Palembang 2 See also 3 References Asian Games [ edit ] 1974 Tehran [ edit ] Main article: 1974 Asian Games Name NOC Sport Banned substance Medals Ref Oh Han-nam South Korea Volleyball (Men) [1] Masushi Ouchi Japan Weightlifting Stimulant (Men's 90 kg) (Men's snatch 90 kg) (Men's clean & jerk 90 kg) [2] Kim Joong-iI North Korea Weightlifting Stimulant (Men's 110 kg) (Men's snatch 110 kg) (Men's clean & jerk 110 kg) [3] 1994 Hiroshima [ edit ] Main article: 1994 Asian Games Name NOC Sport Banned substance Medals Ref Han Qing China Athletics Dihydrotestosterone (Women's 400 m hurdles) [4] Zhang Lei China Canoeing Dihydrotestosterone (Men's C-1 500 m) (Men's C-1 1000 m) (Men's C-2 500 m) [4] Qiu Suoren China Canoeing Dihydrotestosterone (Men's C-2 1000 m) [4] Wang Yan China Cycling Dihydrotestosterone (Women's sprint) [4] Sirisak Kadalee Thailand Football Stimulant [5] Fu Yong China Swimming Dihydrotestosterone (Men's 400 m individual medley) [6] Hu Bin China Swimming Dihydrotestosterone (Men's 50 m freestyle) [6] Lü Bin China Swimming Dihydrotestosterone (Women's 50 m freestyle) (Women's 200 m freestyle) (Women's 200 m individual medley) (Women's 4 × 100 m freestyle relay) (Women's 100 m freestyle) (Women's 100 m backstroke) [6] Xiong Guoming China Swimming Dihydrotestosterone (Men's 200 m freestyle) (Men's 200 m individual medley) (Men's 400 m individual medley) (Men's 4 × 200 m freestyle relay) (Men's 4 × 100 m freestyle relay) [6] Yang Aihua China Swimming Dihydrotestosterone (Women's 400 m freestyle) [6] Zhang Bin China Swimming Dihydrotestosterone (Men's 200 m butterfly) [6] Zhou Guanbin China Swimming Dihydrotestosterone (Women's 400 m freestyle) (Women's 800 m freestyle) [6] 1998 Bangkok [ edit ] Main article: 1998 Asian Games Name NOC Sport Banned substance Medals Ref Abdullah Sabt Ghulam United Arab Emirates Athletics Ephedrine [7] Fakhruddin Abdulmajid United Arab Emirates Karate Ephedrine (Men's kumite 75 kg) [7] Ayed Khawaldeh Jordan Weightlifting Triamterene [8] Jaber Al-Ajmi Kuwait Weightlifting Nandrolone [8] 2002 Busan [ edit ] Main article: 2002 Asian Games Name NOC Sport Banned substance Medals Ref Youssef El-Zein Lebanon Bodybuilding Missed the test ( Men's +90 kg ) [9] 2006 Doha [ edit ] Main article: 2006 Asian Games Name NOC Sport Banned substance Medals Ref Santhi Soundarajan India Athletics Male hormone ( Women's 800 m ) [10] Sayed Faisal Husain Bahrain Bodybuilding ( Men's 70 kg ) [11] Faez Abdul-Hassan Iraq Bodybuilding Nandrolone [12] Kim Myong-hun South Korea Bodybuilding ( Men's 90 kg ) [13] Salem Ghanem Al-Shamsi United Arab Emirates Bodybuilding [14] Kyi Kyi Than Myanmar Weightlifting Diuretic [12] Mya Sanda Oo Myanmar Weightlifting Metabolite ( Women's 75 kg ) [12] Elmira Ramileva Uzbekistan Weightlifting Stanozolol [12] Aleksandr Urinov Uzbekistan Weightlifting Cannabis [12] 2010 Guangzhou [ edit ] Main article: 2010 Asian Games Name NOC Sport Banned substance Medals Ref Suresh Sathya India Athletics Nandrolone [15] Ahmed Dheeb Qatar Athletics Testosterone ( Men's discus throw ) [16] Abdelnasser Awajna Palestine Athletics Norandrosterone [16] Masoud Rigi Iran Boxing Nandrolone [17] Shokir Muminov Uzbekistan Judo Methylhexanamine ( Men's 81 kg ) [18] Jakhongir Muminov Uzbekistan Wrestling Methylhexanamine [19] 2014 Incheon [ edit ] Main article: 2014 Asian Games Name NOC Sport Banned substance Medals Ref Betlhem Desalegn United Arab Emirates Athletics Biological passport abnormalities [20] Khurshed Beknazarov Tajikistan Football Methylhexanamine [21] Nouraddin Al-Kurdi Syria Karate Clenbuterol [22] Yi Sophany Cambodia Soft tennis Sibutramine [23] Park Tae-hwan South Korea Swimming Nebido ( Men's 100 m freestyle ) ( Men's 200 m freestyle ) ( Men's 400 m freestyle ) ( Men's 4 × 100 m freestyle relay ) ( Men's 4 × 200 m freestyle relay ) ( Men's 4 × 100 m medley relay ) [24] Mohammed Jassim Iraq Weightlifting Etiocholanolone [22] Tai Cheau Xuen Malaysia Wushu Sibutramine ( Women's nanquan ) [25] 2018 Jakarta–Palembang [ edit ] Main article: 2018 Asian Games Name NOC Sport Banned substance Medals Ref Kemi Adekoya Bahrain Athletics Stanozolol ( Women's 400 m hurdles ) ( Mixed 4 × 400 m relay ) [26] Sanjivani Jadhav India Athletics Probenecid [26] Nirmala Sheoran India Athletics Drostanolone and Metenolone [27] Kumush Yuldashova Uzbekistan Kurash Stanozolol ( Women's 78 kg ) [28] Pürevdorjiin Orkhon Mongolia Wrestling Stanozolol ( Women's freestyle 62 kg ) [29] Rüstem Nazarow Turkmenistan Wrestling Furosemide [30] See also [ edit ] Asia portal Sports portal Doping at the Commonwealth Games Doping at the Olympics References [ edit ] ^ "South Korea's volleyball silver in the balance" . ... Retrieved 12 April 2013 . ^ "Bodybuilder Syafrizaldy gets Asiad silver" . The Jakarta Post . 16 May 2007. Archived from the original on 7 June 2011 .
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Cyanide Poisoning
Wikipedia
On 5 December 2009, a fire in the night club Lame Horse (Khromaya Loshad) in the Russian city of Perm took the lives of 156 people. ... One of the main causes of death was poisoning from cyanide and other toxic gases released by the burning of plastic and polyurethane foam used in the construction of club interiors. Taking into account the number of deaths, this was the largest fire in post-Soviet Russia. [ citation needed ] On 27 January 2013, a fire at the Kiss nightclub in the city of Santa Maria , in the south of Brazil , caused the poisoning of hundreds of young people by cyanide released by the combustion of soundproofing foam made with polyurethane . ... They also offered courses to the SS in the safe handling and use of the material for fumigation purposes. [50] In April 1941, the German agriculture and interior ministries designated the SS as an authorized applier of the chemical, and thus they were able to use it without any further training or governmental oversight. [51] Hydrogen cyanide gas has been used for judicial execution in some states of the United States, where cyanide was generated by reaction between potassium cyanide (or sodium cyanide [52] [53] ) dropped into a compartment containing sulfuric acid , directly below the chair in the gas chamber . [54] Suicide [ edit ] Cyanide salts are sometimes used as fast-acting suicide devices. ... Robert Ferrante is appealing his conviction. [65] Mirna Salihin died in hospital on 6 January 2016, after drinking a Vietnamese iced coffee at a cafe in a shopping mall in Jakarta . Police reports claim that cyanide poisoning was the most likely cause of her death. ... Terrorism [ edit ] In 1995, a device was discovered in a restroom in the Kayabacho Tokyo subway station, consisting of bags of sodium cyanide and sulfuric acid with a remote controlled motor to rupture them in what was believed to be an attempt by the Aum Shinrikyo cult to produce toxic amounts of hydrogen cyanide gas. [68] In 2003, Al Qaeda reportedly planned to release cyanide gas into the New York City Subway system. The attack was supposedly aborted because there would not be enough casualties. [69] Research [ edit ] Cobinamide is the final compound in the biosynthesis of cobalamin.
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Abortion In Mexico
Wikipedia
"The Decriminalisation of Abortion in Mexico City: How Did Abortion Rights Become a Political Priority?". ... Christian Science Monitor . Mexico City . Retrieved 2009-10-17 . ^ a b "State Legislation" . ... "Judges uphold abortion rights in Mexico City" . The Guardian . Retrieved 2009-10-17 . ^ "Population of Mexico City as a percentage of the national population of Mexico" . ... El Financiero en línea (in Spanish). Mexico City. 2009-10-13. Archived from the original on 2018-10-02 . ... PMID 21972670 . ^ a b ELISABETH MALKIN; NACHA CATTAN (24 August 2008). "Mexico City Struggles With Law on Abortion" .
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Alcohol Myopia
Wikipedia
PMID 14647967 . S2CID 25817991 . ^ Schmitt, WA; CA Brinkley; JP Newman (1999). "Testin Demasio's somatic marker hypothesis with psychopathic individuals: risk takers or risk averse?". ... Brain Research . 508 (1): 65–69. doi : 10.1016/0006-8993(90)91118-z . PMID 2337793 . ^ Sevincer, A. Timur; Oettingen, Gabriele; Lerner, Tobias (2012). ... CiteSeerX 10.1.1.380.3494 . doi : 10.1037/a0025931 . PMID 22004115 . ^ Sevincer, A. Timur; Oettingen, Gabriele (2009). "Alcohol breeds empty goal commitments".
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Klippel-Trenaunay-Weber Syndrome
OMIM
Subsequent progression to right leg hypertrophy was noted in the first 5 years of life. Timur et al. (2004) identified a de novo supernumerary ring chromosome in a patient with mild mental retardation, long tapering fingers, elongated and thin feet, and KTS. ... The de novo translocation t(8;14)(q22.3;q13), reported by Timur et al. (2000) and Wang et al. (2001), points to a pair of chromosomes different from those focused on by Whelan et al. (1995) as the possible site of the Klippel-Trenaunay gene.
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Alopecia, Androgenetic, 1
OMIM
TDT results showed a marginally significant association between androgenetic alopecia and variants 3379-29G/T (P = 0.024) and 2611-68C/T (P = 0.047). These results, however, did not remain significant after applying the conservative Bonferroni correction for multiple testing.SRD5A2, AR, ABCC2, SUPV3L1, VDR, ZFP36, MTHFR, TNFRSF10A, BRD4, ZDHHC13, HR, PRKAR1A, CRH, PARP1, RHOA, WNT10A, C1orf127, FAF1, MKLN1-AS, TBX15, HOXD-AS2, ARL17B, LINC01432, SSPN, SLC14A2, FAM53B, EMC2, HDAC9, EDAR, MAPT-AS1, DRAIC, DKK2, KLF15, MEMO1, RSPO2, KANSL1, MRPS22, LINC00670, LRMDA, OFCC1, DPY30, GORAB, SPPL2C, THADA, GORAB-AS1, EBF1, RUNX1, MAPT, MKLN1, EIF3E, OPHN1, IRF4, FGF5, AGA, EDA2R, KLK3, TGFB1, GGCT, CD200, DKK1, CTNNB1, IGF1, CD34, DPP4, CYP27B1, COX8A, CRP, COL17A1, CARD14, PRNP, NLRP3, FGF2, CDKN2A, MS4A1, CASP3, C4BPA, MIR223, MIR451A, MIR146B, BDNF, XIAP, AGXT, AGT, AKR1C4, IL1B, KRT20, VEGFA, PTPN1, SHBG, SRD5A1, PPARA, ABCB1, OTC, PRDX2, TGFB1I1, TLR4, TNF, TP53, WNT10B, GHR, NFE2L2, NCOA4, LEP, KRT5, ABCB6, DHRS9, IL17A, MMRN1, TBC1D9, PTGDS, HPGDS, TGFBR1
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Fumarase Deficiency
Wikipedia
You can help by adding to it . ( July 2017 ) Treatment [ edit ] There is a deficiency of malate in patients because fumarase enzyme can't convert fumarate into it therefore treatment is with oral malic acid which will allow the Krebs cycle to continue, and eventually make ATP. [ citation needed ] Epidemiology [ edit ] Fumarase deficiency is extremely rare - until around 1990 there had only been 13 diagnosed and identified cases worldwide. [ citation needed ] A cluster of 20 cases has since been documented in the twin towns of Colorado City, Arizona and Hildale, Utah among an inbred community of 10,000 members of the Fundamentalist Church of Jesus Christ of Latter Day Saints . [11] [12] [13] [14] Nicknamed "Polygamist's Down's", the syndrome has been blamed on cousin marriage , but in a larger sense is related to the reproductive isolation of a community among whom 85% are blood relatives of John Y. ... "Fumarate Hydratase Deficiency" . GeneReviews . Seattle WA: University of Washington . PMID 20301679 . ^ Online Mendelian Inheritance in Man (OMIM): Fumarase Deficiency - 606812 ^ Devlin, Thomas M. (2006). ... "Hereditary Leiomyomatosis and Renal Cell Cancer" . GeneReviews . Seattle WA: University of Washington . PMID 20301430 .
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Disseminated Superficial Actinic Porokeratosis
Wikipedia
The thread-like ring is very thin, much like fabric thread for sewing, and raised such that it is both palpable and visible. The interior of the ring may be rough like sandpaper, or smooth. The interior is often discolored, though colors vary from patient to patient.
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2016 Munich Shooting
Wikipedia
Police reportedly used a robot to examine it, [28] and a total of 300 rounds of ammunition were found inside. [29] Police officials warned of "an acute terror situation" and initially thought that there were up to three attackers, but later confirmed that there was only one gunman. [10] [30] The Munich U-Bahn , tram service, bus service, and services on the central portion of the S-Bahn in Munich were stopped. [31] [32] Munich main station was evacuated and all trains were cancelled in and out of Munich. Regional and inter-city trains ceased their service to and from the region of the shooting. [33] Deutsche Bahn provided accommodation trains for stranded commuters and tourists where they could seek refuge. ... He said that he had spent more than four hours in the operations centre on 22 July, and thanked the forces for acting with professionalism and calm. The Interior Minister of Bavaria, Joachim Herrmann , announced an investigation into why there had been numerous false alarms. [86] The German Depression-Help Trust ( Stiftung Deutsche Depressionshilfe ) warned of stigmatizing mentally ill people in reaction to the shooting. [87] After the shooter was revealed to have been born in Germany, the right-wing politician André Poggenburg was condemned and mocked in German media for having previously blamed Merkel's open refugee policy for the shooting. [88] International [ edit ] The U.S. Department of State warned Americans in Munich to "shelter in place". [89] President Barack Obama said in a statement that he pledged support for those affected by the shooting. [28] [90] [91] Czech Interior Minister Milan Chovanec said his country would reinforce its borders to prevent the perpetrator(s) from fleeing into that country, according to German television station n-tv . [27] The Czech Foreign Ministry set up an emergency hotline and urged Czechs to avoid public places. [92] The Iranian Ministry of Foreign Affairs condemned the attack. ... "Munich shooting: 'Shots fired' at OEZ shopping centre in German city" . The Independent . Retrieved 22 July 2016 . ^ "Shooter who killed 9 in Munich was 18-year-old with dual Iranian German nationality" . ... Written inquiry of Katharina Schulze from Mai 2, 2018 with answers of the Bavarian Ministry of the Interior with understanding of the Bavarian Ministry of Justice from 24 July 2018. ^ Joshua Kellogg (17 April 2018).
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Echopraxia
Wikipedia
. ^ Tanner CM, Chamberland J (May 2001). "Latah in Jakarta, Indonesia". Mov. Disord . 16 (3): 526–9. doi : 10.1002/mds.1088 .
- Chandler's Syndrome GARD
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Hiv/aids In Bolivia
Wikipedia
The most recent example is the joint signing in February 2007 of an agreement to implement the Adoption of Attitudes and Practices to Prevent HIV-AIDS at the Interior of the Armed Forces project by the Ministry of National Defense, the Ministry of Health and Sports, the Commander-In-Chief of the Armed Forces, and UNAIDS. [1] Bolivia has been able to mobilise support from the international community, and a large proportion of its funding comes from external sources. ... This article incorporates text from this source, which is in the public domain . v t e HIV/AIDS in South America Sovereign states Argentina Bolivia Brazil Chile Colombia Ecuador Guyana Paraguay Peru Suriname Uruguay Venezuela Dependencies and other territories Falkland Islands French Guiana South Georgia and the South Sandwich Islands v t e HIV / AIDS topics HIV/AIDS HIV HIV Lentivirus structure and genome subtypes CDC classification disease progression rates HIV/AIDS diagnosis management pathophysiology prevention research vaccination PrEP WHO disease staging system for HIV infection and disease Children Teens / Adults Countries by AIDS prevalence rate Conditions Signs and symptoms AIDS-defining clinical condition Diffuse infiltrative lymphocytosis syndrome Lipodystrophy Nephropathy Neurocognitive disorders Pruritus Superinfection Tuberculosis co-infection HIV Drug Resistance Database Innate resistance to HIV Serostatus HIV-positive people Nutrition Pregnancy History History Epidemiology Multiple sex partners Timeline AIDS Museum Timothy Ray Brown Women and HIV/AIDS Social AIDS orphan Catholic Church and HIV/AIDS Circumcision and HIV Criminal transmission Discrimination against people Economic impact Cost of treatment HIV-affected community HIV/AIDS activism HIV/AIDS denialism Red ribbon Safe sex Sex education List of HIV-positive people People With AIDS Self-Empowerment Movement HIV/AIDS in the porn industry Culture Discredited HIV/AIDS origins theories International AIDS Conference International AIDS Society Joint United Nations Programme on HIV/AIDS (UNAIDS) Media portrayal of HIV/AIDS Misconceptions about HIV/AIDS President's Emergency Plan for AIDS Relief (PEPFAR) The SING Campaign Solidays Treatment Action Campaign World AIDS Day YAA/Youthforce "Free Me" Larry Kramer Gay Men's Health Crisis ACT UP Silence=Death Project HIV/AIDS pandemic by region / country Africa Angola Benin Botswana Democratic Republic of the Congo Egypt Eswatini Ethiopia Ghana Guinea Côte d'Ivoire (Ivory Coast) Kenya Lesotho Madagascar Malawi Mali Mozambique Namibia Niger Nigeria Rwanda Senegal Tanzania South Africa Uganda Zambia Zimbabwe North America Canada Mexico El Salvador Guatemala Honduras Nicaragua United States New York City Caribbean Haiti Jamaica Dominican Republic South America Bolivia Brazil Colombia Guyana Peru Asia Afghanistan Armenia Azerbaijan Bahrain Bangladesh Bhutan Cambodia China (PRC) ( Yunnan ) East Timor India Indonesia Iran Iraq Japan Jordan North Korea Laos Malaysia Myanmar (Burma) Nepal Pakistan Philippines Saudi Arabia Sri Lanka Taiwan (ROC) Thailand United Arab Emirates Turkey Vietnam Europe United Kingdom Russia Ukraine Oceania Australia New Zealand Papua New Guinea List of countries by HIV/AIDS adult prevalence rate List of HIV/AIDS cases and deaths registered by region
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Upington Disease
OMIM
INHERITANCE - Autosomal dominant SKELETAL - Enchondromata (cartilaginous tumor growing from interior of bone) - Ecchondromata (cartilaginous tumor projecting under periosteum) - Arthralgias (hips, knees) Pelvis - Premature closure of the capital femoral epiphyses - Widened femoral necks - Flattened femoral heads MISCELLANEOUS - Onset at age 5 years - Majority of cases have bilateral involvement ▲ Close
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Desmosis
Wikipedia
. : “Pathology of Chronic Constipation in Pediatric and Adult Coloproctology“, Karger 2005 ^ Meier-Ruge WA. (1998). "Desmosis of the colon: a working hypothesis of primary chronic constipation". Eur J Pediatr Surg.8; 299-303 ^ Meier-Ruge WA, Bruder E. (2007). "The morphological characteristics of aplastic and atrophic desmosis of the intestine". Pathologe 28: 149-54 ^ Meier-Ruge WA, Bruder E. (2005). "Atrophic desmosis as secondary connective tissue atrophy in muscularis propria".
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Prepapillary Vascular Loops
OMIM
Lambert et al. (1983) reported a family in which a 62-year-old black man had prepapillary vascular loop on the right; his 31-year-old asymptomatic daughter had 'a superior temporal artery distribution that spiraled around the superior temporal vein in several places;' her 28-year-old brother had a right temporal artery that spiraled around its attendant vein twice before bifurcating; and her 6-year-old daughter had 2 small vascular loops at the interior nasal margin of the left optic disc.
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Trichoodontoonychial Dysplasia With Bone Deficiency
OMIM
Although not known to be related, the parents were both born in an 'endogamous community of the interior of Brazil.' Inheritance The inheritance of ectodermal dysplasia in the family described by Pinheiro et al. (1983) appeared to be autosomal recessive.
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Hereditary Mucoepithelial Dysplasia
Wikipedia
Hereditary mucoepithelial dysplasia Other names Urban-Schosser-Spohn syndrome, HMD Structure and location of desmosomes Gap junctions, connecting the interior of two cells Malformation of desmosomes and gap junctions are caused in this condition Specialty Dermatology Hereditary mucoepithelial dysplasia ( HMD ), or simply mucoepithelial dysplasia , [1] [2] is a rare autosomal dominant multiepithelial disorder causing systemic maldevelopment of the epithelia and mucous membranes that line the surface of tissues and structures throughout the body, particularly affecting systems affiliated with mucosa, which includes the respiratory , digestive , urinary , reproductive and immune systems . [2] [3] [4] [5] [6] The disorder is attributed to improper formation of desmosomes and gap junctions , which prevents proper cornification of the epithelial layer of the skin. [5] [7] Contents 1 Pathophysiology 2 Diagnosis 3 Treatment 4 References 5 External links Pathophysiology [ edit ] Desmosomes are extracellular protein structures responsible for cellular adhesion , whereby cells of the same type are held closely together. [8] Gap junctions are specialized channels located within the cell membrane of many animal cell types, which serve as gateways that connect the cytoplasmic interior of two adjacent cells, allowing the passage of small molecules such as ions , nucleotides , second messengers and others. [9] [10] The movement and exchange of small molecules between cells is an important part of intracellular communication processes like cell signaling . [11] Diagnosis [ edit ] This section is empty.