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Severe Acute Respiratory Syndrome
Wikipedia
Retrieved 14 July 2013 . ^ Offeddu V, Yung CF, Low MS, Tam CC (November 2017). "Effectiveness of Masks and Respirators Against Respiratory Infections in Healthcare Workers: A Systematic Review and Meta-Analysis" . ... Archived from the original on 13 May 2016 . Retrieved 11 May 2016 . ^ Low D (2004). Learning from SARS: Preparing for the Next Disease Outbreak: Workshop Summary . ^ "Is Canada ready for MERS?ACE, CXCL6, CXCL1, ACE2, SARS1, VTN, CDSN, SARS2, MBL2, SH2D3A, CXCL10, HLA-A, TMPRSS2, IFNG, CLEC4M, IL6, MX1, IFNB1, HLA-DRB1, MBL3P, CCL2, TNF, OAS1, MYOM2, CCL5, HLA-B, NLRP3, IL10, BST2, IL2, IFNA13, IFNA1, RBM45, ERVK-6, SPECC1, GPT, CD209, EGFR, ERVK-32, MERTK, EBI3, POLDIP2, LINC01672, THPO, COPD, RNF19A, TPO, TRAF3, UBE2I, CBLL2, TRIM25, AIMP2, BCAR3, IL18R1, MUL1, IFIH1, ADAM17, GRAP2, NPIPB3, TMPRSS11D, RIPK3, BAG3, SDS, ISG15, FGL2, MASP2, CKLF, AHSA1, PRRT2, SOCS3, ABCA4, SULT1E1, CR1, FN1, FCER2, ESR1, CTSL, CTRL, MAPK14, CRK, ATF2, CREB1, MAP3K8, RTN2, CD14, CASP3, CASP1, CALR, BCL2L1, B2M, ANPEP, AHSG, AGT, GAPDH, GNL1, GOT1, GPER1, BRD2, RNASEL, RNASE2, RB1, PLAAT4, MAPK1, ACRV1, PRKCA, PPIA, PI4KB, PRKN, NM, NFIC, MIP, IRF3, IL12RB1, CXCL8, IFN1@, ICAM3, PRKCB
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Teratoma
Wikipedia
. ^ Noor, Mohd Rushdan Md; Hseon, Tay Eng; Jeffrey, Low Jen Hui (2014). Gynaecologic Cancer: A Handbook for Students and Practitioners .BCL10, CTNNB1, KIT, STK11, POU5F1, NANOG, SETBP1, FGFR3, POU5F1P4, POU5F1P3, ATN1, SOX2, IGHV1-12, TP53, TRRAP, HSP90B1, PLSCR4, KLF4, DMRT1, AFP, RPE65, SRRM2, GRN, SLC22A3, HDAC1, KRAS, CKAP4, MYC, PSMD10, PTBP1, TP63, UVRAG, PNO1, RBMS3, CDX2, MAK16, BMP2, DND1, LIN28A, MSC, NOG, PRPF4, TIPRL, MBD2, ATOH8, PROM1, FSD1L, CREG1, LHX2, ZFP42, REXO1, NANOS3, MVP, UTF1, GFI1B, LBX1-AS1, HMGA2, XIST, MIR367, MIR373, CHAC2, MIR375, SYCE1L, NKX2-1, PLAA, KLF2, KLHL1, KAT5, CHD7, FBXW7, LSM2, IMP3, MKS1, ESRP1, DDX4, DCDC2, GMNN, DNMT3L, GAS5, TGFB1, PRDM14, FSD1, METTL8, CBX5, SIRT1, MESD, TDGF1P6, CBX3, ASXL3, ITFG1, GADD45G, HPSE, NES, TIMP1, AAVS1, TFAP2C, ERCC1, ABCC2, CSE1L, CSF2RA, DAZL, DHCR24, EGR1, ELF4, ESR1, TCF12, GPC4, FGF2, FHIT, FOXO3, FMOD, NR5A1, FUT1, CISH, CDKN2B, CDKN2A, CDH1, NR0B1, ALPP, ALPG, BIRC5, AQP4, AR, ATM, BAX, BCL2, BRCA1, BRAF, CALD1, CD1A, CD34, CDK1, GABPA, GATA2, GATA6, MRC1, NHS, NOTCH1, PGM1, PIN1, PMAIP1, PTEN, RB1, SLC3A2, SLC5A5, ACAT1, SNAI1, SNRPN, SRY, SSTR2, ZEB1, NFE2L2, MMP9, GDNF, KITLG, GFRA1, GSTP1, HIF1A, MNX1, HMGA1, IL3, JAG2, KRT10, KRT18, LNPEP, EPCAM, MAT1A, MCL1, ME1, MEFV, PSC
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Small-Cell Carcinoma
Wikipedia
However, most people with the disease relapse and median survival remains low. The overall incidence and mortality rates of SCLC in the United States have decreased during the past few decades. [60] Pie chart showing incidence of small-cell lung cancer (shown in red at right), as compared to other lung cancer types, with fractions of smokers versus non-smokers shown for each type. [61] In limited-stage disease, relative 5-year survival rate (both sexes, all races, all ages) is 21.3%; however, women have higher 5-year survival rates, 26.9%, and men have lower survival rates, 21.3%. [62] The prognosis is far more grim in extensive-stage small-cell lung carcinoma where 5-year relative survival rate (both sexes, all races, all ages) is 2.8%; however, women have higher 5-year survival rates, 3.4%, and men have lower 5-year survival rates, 2.2%. [62] Long term survival of more than 5 years can be achieved with proper treatment.SMARCA4, TP53, PYCARD, RB1, CYP2A6, UGT1A1, NPPA, MTOR, BIRC5, CDKN2A, KIT, PDGFRA, NKX2-1, EGFR, H3P10, TTF1, ERG, CHGA, GSTM1, SMARCA2, TMPRSS2, SYP, CD274, NCAM1, SMARCA1, AR, ASCL1, KRAS, SOX2, EZH2, NUTM1, ERBB2, ENO2, CCND1, BCL2, UVRAG, CKAP4, INSM1, STMN1, TP63, SCLC1, AXL, GRP, PAX5, KLK3, POMC, PTEN, ALK, AURKA, RPE65, FOXA2, CDX2, CD44, CHEK1, EWSR1, EML4, ING5, KRT20, BCOR, FBXW7, LOC110806263, RHBDF2, TLE1, LIN28A, THRA, THBD, TGM2, TGFBR2, SF3B6, TGFB1, TERT, DNER, H3P8, MUC16, SYK, SFXN1, CTAG1A, SNCA, SMARCC1, SMARCB1, H3P23, SCGB1A1, TICAM2, LAMTOR2, VIM, POU5F1P4, TMED7-TICAM2, DICER1, POU5F1P3, SATB2, CIC, RASSF1, RPP14, RIPK3, MIR148B, SUB1, YBX3P1, DCTN6, RPL17-C18orf32, IL23R, IGF2BP3, ZNRD2, CDK2AP2, RAD50, SPATA2, FEZ1, NAPSA, TMED7, ARID1A, C17orf97, SMUG1, ABL1, SLC22A3, IGF1R, CTNNB1, CYP1A1, CYP2D6, CYP2E1, DNMT3B, HBEGF, EGF, ETV4, FGFR1, FHIT, FSHR, SFN, MSH6, FOXA1, HRAS, CTAG1B, CREBBP, CLDN4, CALCA, AKT2, APC, STS, FOXL2, BRAF, BSG, CASP8, CPB2, CAV1, CBR1, CCK, CDK4, CDKN1B, CEACAM5, IFI27, IGFBP2, SKP2, IL6, PDCD1, PIGR, PIK3CA, ADA, PIK3CD, PIK3CG, POU5F1, PPARG, PSMD9, RAF1, RET, RNASE3, RPL17, S100A9, SET, PAX3, NOTCH2, NFATC2, MAP2, CXCL8, CXCR2, ISL1, KRT19, LGALS3, SMAD4, MET, MYCL, CD99, MLH1, MRC1, MSH2, MTHFR, MYB, PIK3CB
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Liver Cancer
Wikipedia
Within two years, there is a risk for cancer arising from these nodules of 30–40%. [25] Obesity has emerged as an important risk factor, as it can lead to steatohepatitis . [15] [26] Diabetes increases the risk for HCC. [26] Smoking increases the risk for HCC compared to non-smokers and previous smokers. [26] There is around 5-10% lifetime risk of cholangiocarcinoma in people with primary sclerosing cholangitis . [27] Liver fluke infection increases the risk for cholangiocarcinoma, and this is the reason why Thailand has particularly high rates of this cancer. [28] Children [ edit ] Increased risk for liver cancer in children can be caused by Beckwith–Wiedemann syndrome (associated with hepatoblastoma), [29] [30] familial adenomatous polyposis (associated with hepatoblastoma), [30] low birth weight (associated with hepatoblastoma), [31] Progressive familial intrahepatic cholestasis (associated with HCC) [32] and Trisomy 18 (associated with hepatoblastoma). [30] Diagnosis [ edit ] Further information: Hepatocellular carcinoma § Diagnosis Many imaging modalities are used to aid in the diagnosis of primary liver cancer.TP53, CDKN2A, MYC, TERT, GNMT, PPARA, TGFA, IGF2, FHIT, NR1H4, KRAS, ASNS, APC, STAT3, TNF, CTNNB1, TNFSF10, CCND1, NFE2L2, MALAT1, PPARG, IL2, JUN, IFNA1, AHR, NR1I3, HULC, CYP2E1, ANXA2, HGF, SCD, RAF1, BRAF, NEAT1, ATP7B, MIR29A, IFT88, ANXA7, TCF4, MAPK14, SLC2A1, TOP1, DACT2, ATF3, PTPRO, HRAS, ESR1, FOSB, NDRG1, CDKN1B, HCFC1, OAT, SNX10, GSTM1, LARGE1, PHGDH, HEBP2, CRABP1, DICER1, EXOSC2, PTER, CCNH, TOX3, NCOR1, CPT1B, NUDCD3, WSCD1, TTC39A, ESM1, YIF1A, CGREF1, CHN2, HERC3, TNK2, FST, CCR4, CIDEA, EFNB2, CSF3, LTF, MYO5B, GJB1, GPC3, GPX2, GPX3, GRIK2, KRT18, NAT2, KRT8, HIF1A, ITIH1, IL12B, IL12A, HMOX1, SLC11A2, SERPINE1, ABCB1, PLS1, PRKCE, PSMA4, PTEN, PTGS2, SIX3, SRMS, ZDHHC2, TOP2A, TRIO, UGDH, XPA, XPC, BAP1, SLC40A1, CSF2, CCDC134, TMEM132D, DPP10, MACIR, FLCN, DCD, TTLL9, TRMT11, CLSTN2, WDR17, DDX54, EGLN3, SLC38A9, ZSCAN22, HIGD2A, ADAMTS17, PDRG1, PRICKLE2, RTP3, ASH1L, HSDL2, BTBD11, MACROD2, STAC3, ANXA4, ABL1, APCS, SNHG11, NOP16, GADL1, NUDT7, ACOT1, SPATA21, LINGO2, HNF4A, MET, CASP3, FOXM1, AKR1B1, COL18A1, CADM1, PCNA, MIR145, SRSF1, MIR25, HNF1A, RGN, G6PD, PLAU, PTK2, CASP8, CARM1, DNMT3A, SKP2, CCNE1, SAV1, IL10, FAS, DNMT1, SMAD2, GMPS, MIR93, HNRNPA2B1, ING3, IL6ST, ABCC3, ENG, CTSB, CDKN1A, CASP9, ABCB4, APRT, IQGAP2, TXNIP, SRF, SHC1, EP300, GC, MIR106B, ND5, HNRNPD, ABCA1, INSR, MIR96, SMAD4, MCM7, MECP2, MME, COX1, MIR195, PPAT, GJB2, AKT2, NFE2L1, MIR181C, MIR18A, PFAS, ALDOC, FTH1, POLG, MCM9, A2M, TEK, VAV1, XDH, CAPN3, ACOT12, CDK1, CDH1, MTHFD2, UACA, CTSL, CAD, CSK, HPRT1, PPP1R9A, LPAR1, HAMP, C3, FOXP1, SLC66A3, ASIP, TFRC, TGFBR2, DNMT3B, PIK3CD, PIK3CG, PIK3CA, SLC5A5, PROM1, EPCAM, BCL2, ALB, DLC1, AKT1, MIR122, EGFR, YAP1, CD44, AFP, MIR21, VEGFA, PIK3CB, MAPK1, TGFB1, THY1, MIR34A, COX2, EPHB2, IL6, SIRT1, PKM, GABPA, GRN, MIR221, MTCO2P12, DLEC1, E2F1, ADAM17, HOTAIR, DNLZ, DYNLL1, IL24, IFI27, MIR146A, MTDH, SPP1, HMGA2, ICAM1, ARHGAP1, TBC1D9, TRIB2, KLRC4-KLRK1, CXCL8, TMED7-TICAM2, HSPA5, MEG3, H3P23, KLRK1, ALDH2, MIR155, BMI1, TFDP1, TICAM2, EZH2, PSMD10, PSMD9, MAPK8, ANPEP, SPHK1, TMED7, PNPLA3, NANOG, DCTN6, ZNRD2, MAT2A, XRCC1, MAPK3, MDM2, MTHFR, IFNA13, COMMD3-BMI1, GASAL1, ROS1, SOX2, GOLM1, MIR200A, TAZ, AXIN2, PRKAB1, MAT1A, PRKAA2, PRKAA1, KDR, MMP9, MIR15A, MIR375, HDAC3, PHB, LDHA, MCL1, SQSTM1, MIR27A, PDCD1, SLC9A3R1, MMP2, H3P10, MTOR, GPT, HDAC2, HK2, CDK2, HFE, EGF, TBX3, ACHE, CAV1, HGS, PTPN11, DKK1, LCN2, HSPB3, NOTCH1, ALCAM, CEACAM5, JAG1, PAEP, TLR4, USP22, MUL1, MBD2, JAK1, MIR148A, STK11, REG3A, RUNX3, CCK, SETD2, POU5F1P3, POU5F1P4, UCA1, CXADRP1, SERPINB3, MIR7-3HG, SATB1, MIRLET7B, TRIM13, MEF2D, MIR449A, PPARGC1A, SPG7, GSTP1, ARR3, CCR2, CBLL2, MIR424, NDRG2, CD274, PRKN, DNAJB1, IGF1R, IGF1, MIR203A, FOXA1, FGR, STARD13, SIRT7, CXADR, POU5F1, BECN1, HSPB2, SIRT6, HSPB1, MIR214, NCOA2, CKS1B, MIR22, PLK1, OGT, LOC110806263, FSD1, FOXO1, FSD1L, GAS5, TWIST1, PRKAR1A, AKR1C2, NR1I2, HMGB1, MAP2K7, CASR, MIR33A, MIR199A2, NR1H3, DNM1L, RPL29, SRA1, CLIP1, XAF1, GSTK1, MIR152, PLXNB1, FAH, SPRY2, MIR199A1, XIAP, CCL2, CPQ, FGF19, EEF1AKNMT, RFC1, MIR183, RELA, PTK2B, GRK2, FBP1, FGFR4, MIR15B, MIR204, MSLN, FASN, MIR137, PTGER3, MIR125A, MIR149, PLAAT4, PTBP1, MIR10B, PARP1, MIR182, RDX, POMC, MFN2, RECQL, RASAL1, YOD1, AQP5, CCN2, VCAM1, TNFRSF10B, MAK16, TNFRSF10A, UGT2B7, SPZ1, TTK, KAT2B, CLIP2, HSP90B1, FUBP1, NQO1, TM4SF4, TLR1, SALL4, SMURF1, TNFRSF6B, SPRTN, ZEB2, AIMP2, NR0B2, CUL4A, AXIN1, TET1, SLC7A5, AKR1C3, HHIP, CXCR4, DCN, IRS2, VSIR, BSG, ZFP36, ALX4, RIPK1, XPO1, CDCA5, CIAPIN1, SPAG9, SLC5A2, PIN1, CALD1, APOBEC3B, LAPTM4B, FOXK1, CREB1, CTTN, IFNL3, AKR1B10, AR, EPAS1, SHMT2, EPHA3, PCLAF, EPHB6, SFPQ, SOAT1, SOD2, GDF15, APOBEC3A, DPYD, BAX, UNC119, PNO1, ZEB1, ATM, SLCO6A1, METTL3, EGR1, AURKA, ST13, ASPH, ASL, SRC, ABCG2, FOXO3, PSG2, MIR222, CD151, ATAD2, IGFBP3, GGTLC5P, MIR544A, HNRNPA1P10, MIR590, MICA, TIAM2, CCNB1, CXCR2, MKI67, CXCL9, HPGDS, KITLG, MST1, CBX5, MIR483, HMGA1, MIR503, WWP2, MIR885, MIR499A, MUC1, PES1, SUZ12, CEACAM3, MYCN, APOBEC3A_B, PRDX3, MIR490, SRRM2, RBMS3, GGTLC3, LNCNEF, KISS1, MARCKS, CDKN3, HDAC1, MIR675, SULF1, LGALS3BP, MIR300, IL17A, RPIA, MIR1247, KLRC1, MIR216B, TPX2, KDM1A, CD82, JUNB, JAK2, HLA-A, ACAT1, MXD1, HOTTIP, LATS2, SMAD3, GTF2H1, FLT4, SMAD7, GGTLC4P, ZHX2, GGT2, NUPR1, ILF2, GJA1, IFNG, CEBPA, MIR346, GAPDH, NUP62, KAT5, GATA4, WWTR1, NPC2, MIR372, HSD17B4, MLXIPL, MIR302A, MIR30A, MIR378A, MIR338, DCTN4, CPA4, CELF1, PDGFRA, KHDRBS1, GCK, PBX3, POSTN, NUSAP1, NOTCH3, MIR34B, GGT1, GH1, YTHDF2, HSPA9, PERCC1, HSPG2, CEACAM7, HPSE, CD34, FN1, FOXP3, SERPINA1, STOML2, HNRNPA1, SMUG1, FOS, RTN4R, ELOVL6, XPO5, PINK1, SLC17A5, SND1, MAVS, WNK1, BIRC6, LAT, MARCKSL1, RAB22A, LETMD1, TIGAR, AICDA, CENPM, PLXDC1, AHNAK, MMEL1, CLIC4, RNF19A, FOXL2, POLDIP2, HACE1, CTDSP1, GORASP1, CLEC7A, ZBTB20, SCPEP1, CSMD1, KRT23, PRPF31, MTMR14, BTG1, BTF3P11, ARHGAP9, XPO4, APOBEC3G, NCAPG, ATRNL1, RPRD1B, PHF19, MRPL38, CD19, JCAD, GAS8-AS1, VPS33B, SAMHD1, USP28, GOLPH3, MRPS5, SFMBT2, GPR107, PCDH20, ETNPPL, GATAD1, VPS51, B3GAT3, FNDC3B, CIP2A, DEPDC1, ACKR3, RIN2, MBD3, FXYD5, DUOX1, PPIL3, PCA3, TREM1, GEMIN4, IL22, NOX4, TERF2IP, MIEF1, SLC12A9, CAMK4, UGT1A7, UGT1A9, UGT1A1, CDHR2, SYTL2, OSGIN1, TEX10, NSD3, YTHDF1, DERL2, TM6SF2, NDUFA13, RTEL1, MAGEC2, CAPN6, UFC1, DTL, ANAPC11, AMOTL2, TRPV2, TNFRSF12A, PLAC8, CASP4, IER5, VRK3, GDE1, MED15, ZFR, LEF1, CHCHD2, ANGPTL4, NLK, WWOX, CRYL1, SARS2, TMOD3, PINX1, SLC39A4, NLRP2, URGCP, BTBD7, OGDHL, BBC3, CAND1, LDLRAD4, PBK, ZNF395, ACSS2, SULF2, TEX11, RNF17, CD14, CCL28, SPHK2, B9D1, FSTL5, TCIM, PSMG2, CHPT1, DKK4, DKK3, MARCHF1, ASAP3, TMEM176B, CCNA2, CALML3, IGHVIV-44-1, ANO1, MAT2B, MSTO1, RABGEF1, MAP1S, NAT10, YY1AP1, VPS53, DRAM1, TMEM176A, PDLIM3, PDCD4, CD5L, RBM38, PLXNA3, DKK2, DDR1, EPS8L3, GTSF1, CERS4, POTEKP, MIR26B, ADARB1, MIR27B, ADAR, MIR29C, MIR30D, MIR31, MIR32, MIR320A, ADAM10, ACYP2, ACVRL1, MIR99A, MIR17HG, MIR330, MIR24-2, MIR340, MIR342, MIR370, MIR373, CISD2, ACTG2, MIR382, DUXAP9, MIR429, MIR448, MIR363, MIR20B, MIR433, MIR451A, ADH1C, MIR23B, MIR410, BIN1, LIN28B, ZCCHC13, ST20, HAGLR, ANXA6, MIRLET7C, ANXA5, MIR107, MIR10A, ANXA3, MIR126, ANXA1, ANGPT2, MIR150, ALPP, MIR23A, ALDH1A1, MIR185, MIR186, MIR196A1, MIR196A2, MIR199B, MIR20A, MIR205, MIR210, MIR181A1, MIR217, MIR219A1, ADORA2B, MIR224, MIR409, MIR493, HMBOX1, LINC00554, MIR1258, MIR1307, MIR1228, BAALC-AS1, MIR3664, LUCAT1, THORLNC, LINC00665, SNHG16, MINCR, GMDS-DT, ACADL, ACACA, HEIH, ZNF385D-AS2, CD24, LINC-ROR, LINC00210, ROR1-AS1, PCBP2-OT1, LOC102724197, TP53COR1, WSPAR, CCEPR, ABO, LOC108004545, CNE-2, MAPK6-DT, LNCARSR, SERPINA3, TSPY10, ACTA2-AS1, MIR193B, MIR637, MIR498, MIR525, MIR500A, MIR506, MIR486-1, ACTG1, POTEM, SNHG6, PURPL, CRNDE, MIR421, MIR589, MIR608, MIR613, MIR639, MIR760, MIR92B, MAFIP, TSPY3, MAGED4, ACTB, ACOX1, MIR454, MIR766, CDKN2B-AS1, MIR665, MIR374B, MIR920, MIR935, MIR543, TMEM82, APEX1, BIRC3, HAVCR2, TLN2, SESN2, MARVELD1, ZNF484, LOXL4, SETD3, BGLAP, RPAIN, ACRBP, AFAP1L2, KISS1R, RNASE7, USP30, RIOX2, MASTL, CDCA3, UBASH3B, NKD1, WNT3A, KCNK17, SLC25A21, BCL2A1, PYGO2, IL33, DEPDC7, GGTLC1, BCHE, MTG1, TP53INP1, BCAT1, CEACAM1, TCF7L1, ASPG, CEBPA-DT, GALNT14, TNFAIP8L2, SUV39H2, LIN28A, HAND2-AS1, VASH2, CPSF7, BMPR2, HDAC11, BMPR1A, DHDDS, PDZD7, WLS, SVEP1, ASRGL1, KIF18A, PREX2, CPEB4, BMP4, SRCIN1, BMP2, DUSP16, MOB2, MAGED4B, TXNDC5, BLVRA, MAP1LC3B, NUAK2, SLCO5A1, SHARPIN, CYTOR, CMTM7, NLRP3, TIPRL, TIGD1, ALG1L, RHOA, MPEG1, LTO1, OTUD1, ZEB1-AS1, HOXA11-AS, GPC2, CTAG1A, ARF6, TMEM9, AREG, SERPINA11, AQP9, CYGB, SLC13A5, DLX6-AS1, FAM83H, SCARA5, MT1DP, ABCB5, RSPO2, APOE, ACTBL2, H3P44, PCNAP1, IRF2BP2, NDUFS7, NCR3LG1, ARID2, ARNT, STS, ARSF, VASN, ZNF689, TOP1MT, MRGPRF, THEM4, BAG1, ATRX, PRDX5, ATR, MSI2, OSCP1, KLF17, ALDH7A1, DIS3L2, KCNH8, ATHS, CKS1BP7, FUNDC1, BRI3BP, ATF4, PRICKLE1, E2F7, GSC, SPC24, RNF187, LRATD1, SERPINC1, TMEM74, DEUP1, FBXL2, HOXA7, RAD54B, RASA1, RIT1, RHO, RHEB, RET, KDM5A, RASA2, RARB, NECTIN2, RARA, RAP1A, RAN, RALA, ERCC2, RAC1, RNASE3, ROBO1, ERBB2, RPA1, RPE, RPS27, RRBP1, S100A6, S100B, SAFB, ACSM3, SARS1, SERPINB4, EPS8, SCT, SCTR, CCL20, PYCR1, ERG, XCL1, POLE, PPOX, FHL1, FHL2, POU2F1, POLR2E, FHL3, PRRX1, PTMAP4, FOXC1, PLEC, PIK3R1, PIM1, FOLR1, FOLR2, PPP2R3A, FGA, FER, PRKCI, MAPK6, MAP2K1, MAP2K3, PRL, ACSL1, PSMD4, FABP4, F2, PSMD12, ESRRG, ESRRA, ESR2, PTMA, CXCL11, SDC1, CD80, TAGLN, HNF1B, EDNRB, TBL1X, TBCA, TAT, TARBP1, EIF2S1, TRIM21, SYT1, SYCP1, SULT1A3, STIM1, STAT5B, STAT5A, TCF7L2, PPP1R11, PRDX2, TMBIM6, EDNRA, TERF2, ECHS1, TFCP2, NR2F2, E2F2, DVL1, DPYS, TGFB2, TGFBR1, DPP4, DLD, TIMP1, EIF2S3, SRY, CXCL12, SLC2A4, SMARCA1, SLPI, SLC22A1, SLC19A1, SLC10A1, SLC3A2, ENO1, EIF4E, ENSA, ST6GAL1, SHH, SHBG, SELENOP, SELP, SMARCA4, SMPD1, SUMO3, SUMO2, SNAI1, SNCG, FSCN1, SORD, SOX1, ELK3, SOX4, SOX10, SP1, SPINK1, ELK1, SRD5A2, ELANE, PHKB, PGM5, PGK1, KRT10, LEPR, LEP, LDLR, CFH, STMN1, KRT19, HGFAC, ITGA7, KRT6A, HIC1, KPNA2, KIT, KIR3DL1, HK1, LGALS1, LGALS9, LMNB1, LOX, SMAD1, H2AZ1, MAFG, MAGEA1, MAN2A1, GSTT1, MBL2, GSTA3, GSR, GRP, GRM5, MEN1, MFAP1, JUND, ITGA2, PGF, HSPA1B, IDH2, IDH1, ID1, HTC2, HNRNPC, HSPA4, HSF1, IRS1, AGFG1, HNRNPK, HNRNPU, HPR, HPD, HOXA13, IDUA, FOXA2, NR4A1, IFNB1, IGF2R, IGFBP1, IL1A, HMGCS2, IL2RA, HMGCR, HMGB3, CXCR1, HMBS, HLF, HLA-DRB4, ILK, HLA-DRB1, MGMT, MLH1, MAP3K10, NUP98, ORM1, OPRM1, TNFRSF11B, OGG1, ODC1, GDF2, NRAS, FOXO4, GEM, NPM1, NONO, NME1, NM, NFKBIA, OSM, P4HB, PEBP1, PRDX1, PCK1, PCK2, GATA3, PDCD2, PDE6D, PDGFRB, PDK1, PDK4, ENPP2, SERPINF1, GATA1, ATP8B1, PFKM, NFKB1, NF2, NEK2, GP1BA, GPER1, CXCR3, XCR1, MMP14, MNT, MPL, MPO, MPP1, MPST, MRC1, ABCC1, MSH2, MSI1, MT1H, GLUL, NEDD9, GLI3, GLI2, MTR, MTRR, MUC4, MUTYH, GLI1, GADD45B, MYLK, NASP, NBN, NCK1, NEDD4, SEPTIN2, TIMP2, TIMP3, TJP1, CHAF1A, LRPPRC, ARL4C, ACTR3, ABCB6, GJC1, SMC4, TROAP, CPS1, HDAC6, NR2E3, AKT3, HNRNPDL, RBX1, CLEC2B, TRAP1, BCAP31, CLDN3, PSMD14, GDF11, CD96, SF3B4, RAMP3, LILRB2, RTN3, CITED2, COMT, CCR7, RACK1, PEMT, NDC80, CLIC1, CLDN7, CPT1A, PCSK7, PPIG, NTN1, GRAP2, RECQL4, ADIPOQ, ATF2, KL, TRIP10, NUAK1, CRK, PIWIL1, MAPKAPK2, PTTG1, NOLC1, CRMP1, NCR1, GGPS1, FHL5, PCYT1B, TBPL1, CHD1L, KIF20B, WTAP, AKAP12, NUP155, ISG15, SOCS5, KDM4A, DCAF1, HDAC9, HDAC4, MAML1, CLU, CIRBP, HOXA10, MORC2, LARP4B, SEPTIN6, SCAP, ATF6, CEBPB, CARD8, TDGF1P6, SIVA1, OIP5, CBX3, ACOT7, SLCO2B1, PADI2, POLG2, SASH1, SYNE1, CDK4, CDH17, SIRT5, SIRT4, NCS1, KCNH4, GRIP1, BRD4, RBFOX2, KLHDC2, DAPK2, SNHG1, TRIM29, SLC7A11, SH3BP4, ANXA10, RASSF1, STRAP, AKR1C4, AHSA1, SLCO1B1, TRIM3, CHUK, IGF2BP1, CAMKK2, CXCR6, CTCF, CHI3L1, CHEK1, PLK4, MAP3K2, NES, PLK2, CHD4, NUDT6, CCL27, LYVE1, GADD45G, EHMT2, SPIN1, APOBEC2, ATF7, OGFR, UBE2C, CEBPD, CD160, ZWINT, HHLA2, PTP4A3, XPR1, EXO1, TLN1, ZNF224, CUL5, ADAM12, TFPI2, DEK, MANF, PAX8, ZMYM2, DGKQ, ZNF148, ZBTB16, ZIC2, ZFX, XRCC5, XRCC4, CYP19A1, CYP17A1, NCOA3, TAM, CHAF1B, AKAP17A, ARID1A, TRRAP, CYP2D6, CYP2C9, FZD6, H3C1, H3C4, H3C3, H3C6, H3C11, H3C8, XRCC3, DAPK1, CCNE2, TPT1, TSG101, TRO, DECR1, TRAF6, TRAF3, TRAF2, TPO, AKR1C1, TPM3, DEFB1, CFD, TNFRSF1A, DIO3, TMSB4X, TSPY1, TTR, TXNRD1, SUMO1, UCN, UCP1, DHX9, UGP2, UQCRB, UTRN, DDX3X, VDAC1, VDR, VHL, VRK1, WEE1, WT1, H3C12, H3C10, H3C2, SOCS2, VCAN, CTAG1B, IER3, CTBS, CCN6, CFLAR, CTLA4, MAD1L1, IQGAP1, TRIM24, DLK1, FADD, ADAM9, CTNND1, EIF2B5, EIF2S2, AP1M1, CSE1L, BTRC, H3C7, P4HA2, SOCS3, TM4SF5, PKD2L1, PRC1, CLDN1, DIRAS3, LDB2, CRYZ, LATS1, SLC16A3, TNFSF13, RNGTT, EED, PARG, PLA2G6, SLC25A11, SPOP, TAGLN2, CYP2B6, GNPAT, DYRK2, CUL3, KLF11, RAE1, RGS5, MAP4K3, PPFIA1, PIK3R3, ENC1, TNFRSF25, IKBKG, LGR5, DENR, KMO, AKR7A2, RUVBL1, NCOA1, NUMB, CYP1B1, TNKS, EIF3I, PEA15, MARCO, TRADD, LAMTOR5
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Hepatotoxicity
Wikipedia
Patterns of injury [ edit ] Patterns of drug-induced liver disease Type of injury: Hepatocellular Cholestatic Mixed ALT ≥ Twofold rise Normal ≥ Twofold rise ALP Normal ≥ Twofold rise ≥ Twofold rise ALT: ALP ratio High, ≥5 Low, ≤2 2–5 Examples [45] Acetaminophen Allopurinol Amiodarone HAART NSAID Anabolic steroid Chlorpromazine Clopidogrel Erythromycin Hormonal contraception Amitriptyline , Enalapril Carbamazepine Sulfonamide Phenytoin Chemicals produce a wide variety of clinical and pathological hepatic injury.ABCB1, CA3, CYP2E1, NAT2, CYP2B6, NFE2L2, TNF, DGAT2, MTPN, SLC25A29, SGF29, RDH13, SNX18, CADPS2, ATOH8, TMEM164, TMEM117, NFXL1, SLC10A7, SESN2, MAP1LC3B, UNC93B1, UBA5, TCTN1, SENP2, COQ9, MCCC1, CCDC80, PPTC7, ALDH1L2, ECHDC1, MIR143, MIR142, MIR141, MIR132, MIR130B, MIR130A, MIR125B2, MIR125B1, MIR122, MIR1-1, MIR10B, MIR10A, MIR107, MIR100, MIRLET7I, MIRLET7G, MIRLET7D, MIRLET7C, MIRLET7B, MALAT1, H19, PTF1A, ZDHHC23, DNAJC12, OCIAD1, TMEM38B, PUM1, TUBB4B, BPNT1, AASS, ACTR3, NR1H3, ABI1, NR1H4, NR1I3, XYLB, PAN2, EDEM1, MIR149, GDA, ATG5, GSTO1, FADS2, SLC22A8, ADIPOQ, NREP, LRAT, FCMR, AIFM1, CAP1, PDLIM5, PNRC1, IMMT, UGT1A9, SPIN2A, DHRS7, ATP6V1D, HAO2, LAP3, TMED7, IL22, NOX4, CFAP20, ERLEC1, EIF2AK1, HAVCR1, SLC13A4, HACL1, PANX1, BRD4, GANAB, CCT5, PARK7, RIPK3, MIR148A, MIR152, MIR150, CCR2, MIR1306, MIR1307, MIR1249, MIR1247, MIR1246, MIR1468, MIR885, MIR877, MIR744, MIR766, MIR660, MIR1291, MIR651, MIR629, MIR627, MIR625, MIR592, MIR589, MIR574, MIR532, MIR421, MIR33B, MIR1285-1, MIR1260A, MIR484, MIR3591, MIR1273H, MIR7977, MIR4433B, MIR7704, MIR6852, MIR6815, MIR5196, MIR5588, MIR1343, MIR4492, MIR378I, MIR1304, MIR4516, MIR151B, MIR4507, MIR4448, MIR3615, MIR1260B, MIR378C, MIR764, MIR1303, MIR1290, MIR455, MIR483, F2RL3, MIR210, MIR29C, MIR29B2, MIR27B, MIR23B, MIR23A, MIR222, MIR221, MIR22, MIR218-1, MIR217, MIR21, MIR30A, MIR200C, MIR19A, MIR194-1, MIR193A, MIR192, MIR191, MIR188, MIR181C, MIR18A, MIR17, MIR301A, MIR30B, MIR505, MIR367, MIR503, MIR499A, MIR497, MIR193B, MIR410, MIR452, MIR362, MIR423, MIR378A, MIR361, MIR345, MIR320A, MIR342, MIR338, MIR337, MIR335, MIR328, SULT1C3, MIR99A, MIR93, MIR34C, MIR34A, RGN, WASL, SELENBP1, FLT1, GPT, GRK4, GPD1, GOT1, GCLM, GCLC, GDI1, GC, NR5A2, FMO3, FGA, IL1B, FASN, ACSL1, F3, ERN1, EPHX1, ENO1, CELA1, EIF4EBP2, ECHS1, E2F1, CXCL1, GSN, GSR, GSTA4, IGF1, ACTB, IFNA2, HSPA5, HRH2, HPX, HPD, HMOX1, HMGB1, HLA-DRB1, HLA-DQB1, HLA-B, HLA-A, CFH, HADHA, GSTT1, GSTP1, GSTM4, GSTM3, GSTM2, GSTM1, DSC2, DLAT, DHFR, CANX, SERPING1, BTD, BLVRB, BDKRB2, BDH1, BAX, ARNT, ARG1, APOH, APOE, APOA1, ANXA6, ANXA2, AMBP, ALDOB, ALDH9A1, ALB, AHR, AGT, ADAM8, ACTN4, C3, CAT, GADD45A, SERPINA6, DDB1, DBT, CYP8B1, CYP3A4, CYP2C9, CYP2C19, CYP2A6, CYP1A2, CTSE, CTNNB1, CSF3, CRP, CPS1, CP, COL3A1, ABCC2, CLU, CKB, CHRM3, CDS1, CDC25B, IL1A, IFNG, IL4, S100A11, SRP72, SPP1, SORL1, SORD, SOD3, SOD2, SOD1, SLPI, SHC1, CCL2, RBP1, PLS3, RASA1, PZP, PYGL, PTGS2, PRKDC, PRKCD, MED1, PPARA, PON1, IL6, SULT1E1, SULT2B1, SUOX, TALDO1, NR1I2, GGH, PEX11A, NR0B2, TAGLN2, ACOX3, USP5, REEP5, IL1R2, TUBA1A, VWF, VIM, VEGFA, COL14A1, TTR, CCT3, TLR5, TGFBR1, NR2F2, TF, TBXA2R, POLG, POLR2G, PLG, ABCC1, PLAT, MAP3K5, ME1, MDH1, DNAJB9, MAT1A, LTF, FADS1, LGALS3, LCN2, LBP, KRT18, KRT8, KNG1, JUND, ITPR1, IRAK1, CXCL10, IL18, IL17A, IL11, MMP9, MMP2, MST1, OGDH, PGM1, PDK4, PCYT1A, PCOLCE, PC, PAH, P4HB, MIR6741, NDUFS3, NME2, MST1R, MTHFR, PNP, NOTCH1, KITLG, OR51E2, HPRT1, CYP2A7, OAS1, LTB4R, FTL, HBA2, GABPA, PPIG, HSPA1L, HPGDS, PECAM1, TLR4
