Glioma Susceptibility 4

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Retrieved
2019-09-22
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For a general phenotypic description and a discussion of genetic heterogeneity of glioma, see GLM1 (137800).

Mapping

Pannu et al. (2002) studied genetic linkage in 15 familial glioma pedigrees ascertained through patients operated on at Tampere University Hospital and drawn from an area of 1 million inhabitants in western Finland. They hypothesized that the patients might carry the same low penetrance susceptibility allele. Pannu et al. (2002) used a 2-stage strategy for gene mapping. A genome screen in 4 families revealed 4 areas of interest; additional markers in these regions provided evidence of significant linkage to chromosome 15q23-q26.3 with a maximum nonparametric linkage score of 3.35 with marker D15S130. Investigation of all 15 glioma families by association analysis (haplotype pattern mining) and through use of the transmission-disequilibrium test gave further evidence of significant association/transmission distortion at the same 15q locus. No evidence of involvement of known tumor syndromes was obtained from the data provided by the linkage analysis or hospital records.