T-Cell Large Granular Lymphocyte Leukemia

Watchlist

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Retrieved

2021-01-23

Source

Orphanet

Trials

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Genes

STAT3, STAT5B, NCAM1, SOAT1, IL15, STAT1, B3GAT1, TRBV20OR9-2, MS4A1, IL2, VDR, KRT20, TNFAIP3, TRG, TRD, NCR1, KLRK1, CNTN2, PKHD1L1, MICA, CASP8, SBF1, RAB4A, MAP3K5, JAK3, IL15RA, IFNG, HTC2, HRES1, CXCR3

Drugs

Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus, Iodine (131I) tositumomab, Pralatrexate ( FOLOTYN )

Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus, Iodine (131I) tositumomab, Pralatrexate ( FOLOTYN ), Siplizumab, haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate

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T-cell large granular lymphocyte leukemia (T-cell LGL leukemia) is a lymphoproliferative malignancy that arises from the mature T-cell (CD3+) lineage.