Colchicine Resistance

Watchlist

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Retrieved

2019-09-22

Source

OMIM

Trials

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Genes

ABCB1, ABO, AFP, ABCC6, CRP, FOXC1, MEFV, ABCC1, PAK3, TBC1D9, NOD2, MARCKSL1, WLS

Drugs

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A number sign (#) is used with this entry because mutation in the ABCB1 gene (171050) has been found to cause colchicine resistance.

Chamla et al. (1980) described variants of human cells with altered colchicine sensitivity. These cell lines showed cross-resistance to daunomycin, emetine, vinblastine, and vincristine, and collateral sensitivity to xylocaine. Colchicine-resistant mutants of Chinese hamster ovary (CHO) cells have been found to have a change in the entry of drugs into cells, altered binding of colchicine to its intracellular target, or an altered tubulin. Chamla and Begueret (1982) showed that the 'defect' was one of decreased permeability to the drug.