Deafness, Autosomal Recessive 85

Clinical Features

Shahin et al. (2010) reported a large consanguineous Palestinian family with autosomal recessive prelingual nonsyndromic hearing loss.

Mapping

By genomewide linkage analysis of a consanguineous Palestinian family with hearing loss, Shahin et al. (2010) found linkage to an 11.1-Mb region on chromosome 17p12-q11.2 (lod score of 7.25) between markers rs230884 and rs12603885, which they designated DFNB85. Although the MYO15A gene (602666) lies in this region, full sequencing revealed no functional mutations. Shahin et al. (2010) concluded that a second gene for hearing loss lies in this region.