Hepatoblastoma
Watchlist
Retrieved
2022-04-26
Source
Trials
—
Genes
CTNNB1,
IGF2,
APC,
TGFA,
PCNA,
GPC3,
TP53,
AXIN1,
ABCB1,
CDKN2A,
HNF1A,
PPARA,
CDK1,
MYC,
CDKN1A,
PTK2,
INSR,
CDH1,
KRAS,
MET,
CASP3,
HNF4A,
DNMT1,
ABCA1,
ENG,
NR1H4,
TERT,
FAS,
XDH,
HAMP
CTNNB1,
IGF2,
APC,
TGFA,
PCNA,
GPC3,
TP53,
AXIN1,
ABCB1,
CDKN2A,
HNF1A,
PPARA,
CDK1,
MYC,
CDKN1A,
PTK2,
INSR,
CDH1,
KRAS,
MET,
CASP3,
HNF4A,
DNMT1,
ABCA1,
ENG,
NR1H4,
TERT,
FAS,
XDH,
HAMP,
SAV1,
TFRC,
IL10,
IL6ST,
TGFBR2,
COL18A1,
HPRT1,
HNRNPD,
HNRNPA2B1,
VAV1,
MTHFD2,
SMAD2,
RGN,
GJB2,
GC,
G6PD,
FTH1,
FOXM1,
FHIT,
MCM9,
GMPS,
MIR106B,
MIR145,
EP300,
HIF1A,
SMAD4,
PTGS2,
NFE2L1,
PTEN,
IQGAP2,
CADM1,
PPAT,
FOXP1,
POLG,
PLAU,
GNMT,
ABCB4,
SRSF1,
PFAS,
SHC1,
TXNIP,
TEK,
LPAR1,
ND5,
COX1,
ING3,
UACA,
MME,
SKP2,
MECP2,
PPP1R9A,
SRF,
MCM7,
CARM1,
A2M,
ABCC3,
CASP9,
MIR96,
AKR1B1,
CTSL,
CTSB,
CSK,
APRT,
MIR195,
MIR25,
ASNS,
MIR93,
AKT2,
ALDOC,
C3,
CAD,
DNMT3A,
CCNE1,
DNMT3B,
MIR181C,
MIR18A,
CAPN3,
CASP8,
CDKN1C,
H19,
KCNQ1OT1,
KCNQ1,
SETBP1,
SKIV2L,
AFP,
SLC37A4,
TTC37,
H19-ICR,
GPC4,
TNF,
IL6,
SELENOI,
TBC1D9,
NQO1,
APOB,
BCL2,
YAP1,
IL1B,
AXIN2,
EGFR,
NFE2L2,
ACTB,
PLAG1,
GATA4,
VEGFA,
THPO,
TAC1,
SMARCB1,
GLUL,
HGF,
PIK3CD,
PSC,
PLK1,
PIK3CG,
EPCAM,
PIK3CA,
PIK3CB,
EPO,
CYP3A4,
PROM1,
MIR21,
APOA1,
CAT,
KRT19,
RASSF1,
APOE,
HSPG2,
ALB,
MYCN,
DCTN6,
SLC22A18,
SERPINA7,
MIR492,
SERPINB3,
SPOP,
GPR162,
ROCK1,
REG1A,
PSMD9,
ADIPOQ,
DKK1,
H3P23,
ZNRD2,
SREBF2,
CCND1,
ATM,
DKK3,
AKT1,
TMED7-TICAM2,
AGT,
POR,
TACR1,
EGF,
MT1G,
CDKN1B,
CDKN2C,
CEBPA,
IGFBP3,
IGFBP2,
IGF1,
IFI27,
ICAM1,
SLC38A1,
HOXD13,
HLF,
GLI1,
GCG,
SLCO6A1,
MTOR,
AMER1,
MIR193A,
TICAM2,
GSTK1,
ELANE,
PIM3,
TMED7,
MLH1,
SERPINA6,
CD44,
TUG1,
MSH2,
MIR214,
GREB1,
PCLAF,
KEAP1,
ASZ1,
MIR19B1,
NR1I3,
GOLM1,
MIR206,
SAR1B,
ZFAS1,
PGR-AS1,
ATRAID,
STUB1,
CTXND1,
SIGMAR1,
TPPP2,
MYCNOS,
MIR378A,
NLRP3,
WDR20,
ZNF197,
SLC35G1,
LAMTOR1,
IL1RL1,
MIR17,
BTRC,
MALAT1,
ERRFI1,
CLDN2,
CLDN1,
NEAT1,
HGS,
PCSK9,
CIB2,
SLC33A1,
PPIG,
CDC20B,
LOC110806263,
ABCG2,
EEF1E1,
PRDX6,
KLK4,
H3P12,
MIR371A,
DERL3,
DNLZ,
MIR302D,
DLK1,
MIR1250,
SIRT1,
MIR34A,
SF3B1,
SMUG1,
OIP5-AS1,
WWTR1,
IL25,
LPIN1,
POTEF,
POU5F1P4,
DRAM1,
CRNDE,
HHIP,
POU5F1P3,
NDRG2,
PNPLA2,
APOM,
DESI1,
CAPRIN2,
MYDGF,
ASAP1,
CIB1,
NKD1,
SYVN1,
HTATIP2,
MIR217,
DERL2,
MIR222,
KREMEN1,
POSTN,
ANLN,
RALY,
MIR224,
CXXC4,
MIR4510,
LUCAT1,
UHRF1,
ASRGL1,
DLL1,
PIM2,
NANOG,
CELF1,
PTCH1,
FADD,
GLB1,
NR5A2,
FN1,
FOXG1,
FGFR3,
FAP,
F7,
F2,
EZH2,
ESRRB,
ESR1,
ERBB2,
EPOR,
EPHB2,
EIF4EBP1,
DVL2,
GABPA,
HAL,
BECN1,
HDAC1,
LECT2,
LDLR,
LCN2,
CXCR2,
IGF1R,
IFNG,
MRPL58,
HTC2,
HSPB1,
HSPA5,
HES1,
HMOX1,
HMGCS1,
HK1,
HDAC2,
DPEP1,
DNASE1,
DAPK3,
CYP7A1,
BAK1,
BAAT,
ATP6V0A1,
ATP6V1B1,
ATP4A,
ATP12A,
ARG1,
FASLG,
APOC3,
BIRC5,
ANPEP,
ALPG,
AHR,
AGTR1,
PARP1,
BAX,
BRCA2,
CALCA,
CFTR,
CYP2B6,
CYP1A2,
CYP1A1,
CST3,
CLDN7,
ABCC2,
CFL1,
CCK,
CEBPB,
CDKN3,
CDKN2B,
CDC25C,
CD34,
CCNA2,
LIF,
CYP4F3,
SMAD7,
S100A6,
TGFB1,
TEP1,
TEAD4,
ZEB1,
TBX3,
TAZ,
TAT,
ABCC8,
STAT3,
SOX2,
SOAT1,
SLC6A6,
SHH,
SHBG,
SFRP1,
THY1,
TLR4,
TMSB4X,
YY1,
SOCS1,
TEAD2,
ACOX2,
MAFK,
USP7,
MAP3K12,
WT2,
TOP1,
WNT1,
VIPR1,
UROD,
UCP2,
UBE2I,
TTR,
CXCL5,
RRM1,
CD46,
RPL36A,
SERPINE1,
P2RX5,
OXA1L,
OTC,
NOS2,
NOS1,
NQO2,
NEUROD1,
MTTP,
MT1F,
MT1B,
CITED1,
MPO,
MDM4,
MDM2,
REG3A,
SERPINF1,
ATP8B1,
PSMD10,
RBBP8,
RB1,
PVT1,
NECTIN1,
PTPN13,
PTPN11,
MAPK3,
PIM1,
MAPK1,
PTPA,
PPBP,
PPARG,
POU5F1,
POLD1,
H3P10
Drugs
—
Registered!

Hepatoblastoma is a rare malignant (cancerous) tumor of the liver that usually occurs in the first 3 years of life. In early stages of the condition, there may be no concerning signs or symptoms. As the tumor gets larger, affected children may experience a painful, abdominal lump; swelling of the abdomen; unexplained weight loss; loss of appetite; and/or nausea and vomiting. The exact underlying cause of hepatoblastoma is poorly understood. Risk factors for the tumor include prematurity with a very low birth weight, early exposure to hepatitis B infection, biliary atresia, and several different genetic conditions (i.e. Beckwith-Wiedemann syndrome, familial adenomatous polyposis, Aicardi syndrome, Glycogen storage disease, and Simpson-Golabi-Behmel syndrome). Treatment varies based on the severity of the condition but may include a combination of surgery, watchful waiting, chemotherapy, and/or radiation therapy.