Presenile Dementia, Kraepelin Type

A nonspecific type of familial presenile dementia apparently distinct from both Alzheimer disease (104300) and Pick disease (172700) was described by Schaumburg and Suzuki (1968) in 6 persons in 3 generations with male-to-male transmission. The histologic changes corresponded to those described for Kraepelin disease ('catatonia of Kraepelin'). In 4 of the 6 persons, onset was at a very early age: 28, 31, 33 and 34 years.