Parotitis, Juvenile Recurrent

Clinical Features

Reid et al. (1998) reported 4 individuals from 2 generations of a family who had recurrent episodes of parotitis beginning in childhood and, in the only adult at the time of report, remitting at the age of 14 years. In this individual, however, the episodes recurred during each of 2 pregnancies. Parotid gland ultrasonography demonstrated areas of punctate calcification and abnormality of parotid gland texture. Reid et al. (1998) also reported 2 additional individuals from previous generations of the same family who had experienced recurrent episodes of salivary gland swelling in one case and unilateral facial pain in the other case. A right submandibular calculus was found in the individual who had had episodes of salivary gland swelling.

Inheritance

Reid et al. (1998) stated that the transmission pattern of parotitis in the pedigree they reported was consistent with autosomal dominant inheritance with incomplete penetrance and variable expression since the mother of one affected individual was clinically unaffected but was shown to have flecks of calcification in the parotid gland, consistent with previous parotitis.