Colorectal Cancer, Susceptibility To, 11

For a phenotypic description and a discussion of genetic heterogeneity of colorectal cancer, see 114500.

Mapping

In a metaanalysis of 2 previously published genomewide association (GWA) studies (Tomlinson et al., 2008; Tenesa et al., 2008) comprising 13,315 individuals, Houlston et al. (2008) found an association between susceptibility to colorectal cancer and rs961253 on chromosome 20p12.3 within an area bereft of genes (p = 8.9 x 10(-7)). Pooling data from 4 independent case-control series comprising 13,408 individuals with the GWA series yielded a combined p value of 2.0 x 10(-10) for rs961253.