Alk-Positive Large B-Cell Lymphoma
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Drugs
3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione hydrochloride,
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus
3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione hydrochloride,
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus,
Autologous CD4+ and CD8+ T cells expressing a CD19-specific chimeric antigen receptor,
Autologous engineered anti -CD19 Chimeric Antigen Receptor (CAR +) T -cells
(
KYMRIAH
),
Axicabtagene ciloleucel
(
YESCARTA
),
Brentuximab vedotin
(
ADCETRIS
),
Enzastaurin hydrochloride,
Everolimus
(
AFINITOR,
VOTUBIA
),
Humanised Fc engineered monoclonal antibody against CD19,
Humanised anti-CD37 monoclonal antibody conjugated to maytansinoid DM1,
Ibrutinib
(
IMBRUVICA
),
Iodine (131I) tositumomab,
Lenalidomide
(
LENALIDOMIDE ACCORD,
REVLIMID
),
Mocetinostat,
Obinutuzumab
(
GAZYVA,
GAZYVARO
),
Pixantrone dimaleate
(
PIXUVRI
),
Polatuzumab vedotin
(
POLIVY
),
Pralatrexate
(
FOLOTYN
),
Recombinant histidine-tagged idiotype immunoglobulin Fab fragment of clonal B-cell receptors,
Rituximab
(
BLITZIMA,
MABTHERA,
TRUXIMA,
RITEMVIA,
RITUXAN,
RITUZENA,
RIXATHON,
RIXIMYO,
Ruxience
),
Selinexor
(
XPOVIO
),
Tazemetostat
(
TAZVERIK
),
Valproic acid, sodium,
Venetoclax
(
VENCLEXTA,
VENCLYXTO
),
haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate
Registered!
A very rare variant of diffuse large B-cell lymphoma (DLBCL) mainly affecting middle-aged immunocompetent men and characterized by a consistent primary involvement of lymph nodes (mainly in the cervical and mediastinum lymph nodes) and with infrequent extra nodal involvement of the bone marrow and other extra-nodal sites (head and neck region, liver, spleen, and gastrointestinal tract). It has an aggressive disease course, and is associated with a poor prognosis.