Precursor T-Cell Acute Lymphoblastic Leukemia
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
PHF6,
CNOT3,
TAL1,
TLX1,
NOTCH1,
FBXW7,
ABL1,
MYB,
LMO1,
IL7R,
RPL10,
RPL5,
BAX,
BCL10,
LMO2,
BCL2,
TLX3,
BCL11B,
NUP214,
CDKN2A,
MYC,
STIL,
BCR,
SET,
MLLT10,
FLT3,
TRG,
TRD,
PTPN2,
PICALM
PHF6,
CNOT3,
TAL1,
TLX1,
NOTCH1,
FBXW7,
ABL1,
MYB,
LMO1,
IL7R,
RPL10,
RPL5,
BAX,
BCL10,
LMO2,
BCL2,
TLX3,
BCL11B,
NUP214,
CDKN2A,
MYC,
STIL,
BCR,
SET,
MLLT10,
FLT3,
TRG,
TRD,
PTPN2,
PICALM,
JAK3,
MTOR,
PTPRC,
CCND3,
TRB,
STAT5B,
DNM2,
TYK2,
TRA,
SPI1,
STAT1,
MYCN,
KDM6A,
ZFP36L2,
ABCG2,
TCL1A,
CTCF,
ZBTB16,
DDX3X,
SMARCA4,
SALL2,
ECT2L,
HNRNPH1,
PTEN,
PIK3CA,
AKT1,
PIK3CB,
TMEM132D,
PIK3CG,
PIK3CD,
KRT7,
PMEL,
HOXA@,
CD38,
NOTCH3,
DLL1,
PSMB6,
SCLY,
RUNX1,
TRBV20OR9-2,
LYL1,
TP53,
IL7,
KMT2A,
ETV6,
YY1,
CDKN2B,
NUP98,
CXCR4,
CD34,
MTAP,
ATM,
HES1,
NKX2-5,
MEF2C,
PDLIM5,
IKZF1,
H3P10,
OPN1SW,
TNFSF10,
LINC02605,
MIR223,
IL2,
KLF4,
SNAP91,
CALM3,
CALM2,
NR3C1,
CALM1,
TAL2,
RAP1GDS1,
TNF,
CD47,
ABCB1,
MME,
CDK4,
JAK1,
JAK2,
TARP,
WT1,
GLIS2,
LCK,
MBD2,
TRGC1,
CRLF2,
CDKN1A,
PDIK1L,
TRDC,
DNMT3A,
TRDD3,
SAI1,
IL2RG,
CYLD,
TRDJ1,
CD44,
MTTP,
IGF1R,
S100A4,
HMGA1,
IRAK1,
FOXM1,
MSX1,
HIF1A,
NRAS,
CD46,
MCL1,
FOXO3,
CTNNB1,
FHIT,
CCR9,
CCR7,
RASGRP1,
SOS1,
CDKN1B,
STAT5A,
MIR21,
CD79A,
CD33,
CD19,
CD7,
CD1A,
TERT,
NR2E1,
ADD3,
TNFRSF10B,
ASPG,
SOAT1,
KIT,
MAP2K7,
EZH2,
KDM6B,
USP9X,
TAF1,
PAX5,
NT5C2,
HNF1A,
TCF7,
SUZ12,
TCOF1,
PIM1,
KDM1A,
TFRC,
PAWR,
VAV1,
F2RL3,
USP7,
ALDH1A2,
RTEL1,
MLRL,
FOXP3,
MALT1,
SUB1,
PRKCQ,
RAG2,
MAP3K20,
MRPL28,
PTK7,
OLIG2,
NEUROD1,
CXCL12,
PDCD4,
ST6GAL1,
SKP2,
IKZF3,
TBC1D9,
MAPK8,
STAT3,
MSH2,
MPO,
NXT1,
MAPK1,
MMP1,
CILK1,
KRAS,
DLL4,
FANCD2,
MIR146B,
PLEKHG2,
HOXA10,
HOXA9,
BAALC,
ASRGL1,
XRCC6,
CASP3,
MIR196B,
NRARP,
ARID5B,
CCND2,
FANCB,
CD22,
BMI1,
ETS1,
ERG,
CDK2,
CDK6,
EGFR,
ATN1,
MIR19B1,
MIR150,
TIMM8A,
TET2,
CCR4,
CSF2,
COX8A,
HSF1,
PWAR4,
BCL6,
H3P9,
CCND1,
IGFBP7,
XIAP,
THAP1,
IFNG,
IGF1,
IGH,
DEL11P13,
LDB1,
ABCC5,
MIR181A1,
EDIL3,
MIR2909,
KLRC4-KLRK1,
SMC4,
MIR204,
DNM1L,
PROM1,
MIR200B,
MIR26B,
PTPRU,
MIR663B,
NRP2,
MYB-AS1,
MIR141,
SNHG5,
H3P5,
MIR106A,
TRIM13,
MIR139,
DHRS9,
GATD3B,
MIR142,
MIR20A,
MIR146A,
EBI3,
NALT1,
IL18R1,
FEM1B,
MIR17,
MIR29A,
ALL1,
MIR29B1,
NR1I3,
MIR576,
NUP155,
MIR451A,
MIR452,
MIR485,
TCL1B,
PTGES,
GDF15,
ATG5,
MED12,
CLDN10,
MIR193B,
GRAP2,
COX5A,
LHX2,
ARHGEF2,
CXADRP1,
SOCS5,
HDAC4,
TOX,
MIR20B,
MAGI1,
MAFB,
MIR29B2,
MIR30A,
MIR1290,
MIR664A,
MIR17HG,
MIR708,
ZFAS1,
MIR590,
SLC7A7,
LNCR1,
MIR363,
ZEB2,
MSLN,
MAML1,
AHSA1,
TRIM59,
TRBV16,
TRAV29DV5,
ZMIZ1,
CNOT6,
TRBC1,
STIM2,
POLD4,
PRDM16,
PRDM14,
TRBV7-9,
DEPTOR,
TMEM102,
FRTS1,
IGHJ2,
IRX3,
BBC3,
MUL1,
EFL1,
LATS2,
NANOG,
GNL3,
TRAJ60,
TRAC,
CD274,
RMC1,
DENR,
BCOR,
PINX1,
MSTO1,
SHQ1,
WWOX,
ASB2,
ATF7IP,
CCAR1,
LEF1,
DIABLO,
APIP,
POLE4,
SLC2A4RG,
NMD3,
POGLUT1,
SLC12A9,
A1CF,
AVEN,
SCD5,
POLDIP2,
AUTS2,
HENMT1,
RASGRP4,
JDP2,
RASSF1,
CTCFL,
CNKSR3,
CBLL2,
NKX2-3,
TNFSF13B,
UBR1,
PRSS55,
KHDRBS1,
CERS6,
GNLY,
CCT4,
FAM133B,
ASPM,
ATG7,
MERTK,
RACK1,
WIF1,
DNER,
SETBP1,
LRSAM1,
CCDC28A,
RNF19A,
PANX1,
DAPK2,
TET1,
VMP1,
ROPN1L,
TCHP,
CARD11,
MAML2,
HEY2,
BRD4,
SIRT1,
DICER1,
USP24,
SPZ1,
ORAI1,
KLRK1,
MCU,
AKR1C3,
ABCA2,
LMO4,
GATA1,
FUT1,
FRAXE,
FOSB,
FOS,
AFF2,
FGFR1,
FCGRT,
FCER2,
EWSR1,
MECOM,
ETV5,
ETS2,
EPHB6,
EPHB2,
EML1,
EIF4A2,
EIF4A1,
DUSP1,
DTX1,
DNTT,
DNMT3B,
DNMT1,
DNASE1L3,
DHFR,
AKR1C1,
GABPA,
GATA3,
MAPK14,
GFER,
IL18,
IL17A,
IL16,
IL10,
CXCL8,
IL4,
IL3RA,
IL2RB,
IL1B,
RBPJ,
IGHM,
IARS1,
HTC2,
HSP90AA1,
HSD17B1,
HRAS,
HPRT1,
HOXD@,
HOXA13,
HOXA11,
HOXA7,
HNMT,
HHEX,
GRIA1,
GPER1,
CXADR,
CRYZ,
ITGAM,
RUNX2,
CALR,
CALCR,
CA12,
C3,
BTG1,
ZFP36L1,
BRCA2,
BRAF,
BRCA1,
BCL2L1,
NKX3-2,
AVPR2,
ASPA,
ASIP,
ARSA,
ARRB1,
ARR3,
FAS,
APRT,
APAF1,
JAG1,
PARP1,
ADD1,
ACTB,
ABL2,
CASR,
CBFB,
CRMP1,
CCK,
CRK,
CREM,
CREBBP,
ATF2,
CPOX,
COL4A5,
CCR6,
CLTC,
CKS2,
CKS1B,
CHRNA4,
CHRM3,
CHKA,
CHEK1,
CFTR,
CDKN2C,
CDC25A,
CD59,
CD6,
CD5,
CD247,
CD3E,
CD3D,
CD2,
CCNC,
INPP5D,
JUN,
IRS4,
TFAP2C,
ZEB1,
TCF3,
TAPBP,
TALDO1,
MAP3K7,
STIM1,
SRC,
SPG7,
SOX4,
SLC9A1,
SLC6A8,
SLC1A2,
SIAH2,
SEMA3F,
ABCA3,
S100A8,
RPS15,
RPS6KA3,
RPL22,
RPL15,
ROS1,
RHO,
REG1A,
RBBP8,
RASGRF1,
TF,
TGM2,
RASA1,
THBS1,
FOXN1,
NR0B2,
GATD3A,
TAM,
CDR3,
SLC7A5,
HMGA2,
AIMP2,
DEK,
ZFX,
ZFP36,
WNT11,
TRPV1,
UTRN,
UFD1,
UCN,
U2AF1,
TYMS,
TSC2,
TSN,
TRAF5,
CRISP2,
TPD52,
TLE1,
NKX2-1,
RASA2,
RAF1,
JUNB,
NHLH1,
NFE2L2,
NFATC3,
NF1,
NCAM1,
NBN,
NAP1L1,
MSX2,
ABCC1,
MPST,
MMP9,
MMP2,
AFDN,
MLLT1,
MAP3K10,
CD99,
MFAP1,
MEIS1,
MCM2,
MATK,
SMAD3,
LTBR,
LTB,
AFF3,
CD82,
JUND,
NFKBIE,
NKX3-1,
RAC1,
NOTCH2,
PTPN11,
PTPN6,
PTPN1,
PSEN1,
PRL,
PRKCA,
PRKAR1A,
PRKAB1,
PRKAA2,
PRKAA1,
PTPA,
PMAIP1,
PLP2,
PLK1,
PITX1,
PIN1,
SLC25A3,
PDGFRA,
PDCD1,
PCNA,
PBX2,
PAX6,
PRKN,
SIX6,
YBX1,
CCL25
Drugs
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Registered!
A rare acute lymphoblastic leukemia characterized by a neoplasm of lymphoblasts committed to the T-cell lineage, involving bone marrow and blood. A value of >25% bone marrow blasts may be used to define leukemia (as opposed to lymphoma) in cases with the presence of a mass lesion in addition to bone marrow involvement. Patients typically present with leukocytosis, and frequently with a large mediastinal or other tissue mass. Lymphadenopathy and hepatosplenomegaly are common.