Hypomyelination And Congenital Cataract

Clinical characteristics.

Hypomyelination and congenital cataract (HCC) is usually characterized by bilateral congenital cataracts and normal psychomotor or only mildly delayed development in the first year of life, followed by slowly progressive neurologic impairment manifest as ataxia, spasticity (brisk tendon reflexes and bilateral extensor plantar responses), and mild-to-moderate cognitive impairment. Dysarthria and truncal hypotonia are observed. Cerebellar signs (truncal titubation and intention tremor) and peripheral neuropathy (muscle weakness and wasting of the legs) are present in the majority of affected individuals. Seizures can occur. Cataracts may be absent in some individuals.

Diagnosis/testing.

The diagnosis of HCC can be established in individuals with typical clinical findings, characteristic abnormalities on brain MRI, and biallelic pathogenic variants in FAM126A identified by molecular genetic testing.

Management.

Treatment of manifestations: Cataract extraction usually in the first months of life. Therapy support for developmental delays; special education; physical medicine and rehabilitation for spasticity and ataxia. Consider pharmacologic agents for spasticity; antiepileptic drugs as needed. Treatment for scoliosis and contractures per orthopedist; feeding therapy and or gastrostomy tube as needed.

Surveillance: Eye examinations if cataracts were not identified in neonatal period. Developmental, neurologic, and musculoskeletal assessments at each visit. Growth measurement, nutrition assessment, and assessment of family need for social work support and care coordination at each visit.

Genetic counseling.

HCC is inherited in an autosomal recessive manner. If both parents are known to be heterozygous for a FAM126A pathogenic variant, each sib of an affected individual has at conception a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being unaffected and not a carrier. Once the FAM126A pathogenic variants have been identified in an affected family member, prenatal testing for a pregnancy at increased risk and preimplantation genetic testing are possible.

Suggestive Findings

Hypomyelination and congenital cataract (HCC) should be suspected in individuals with the following clinical findings [Biancheri et al 2007] and characteristic abnormalities on brain MRI [Rossi et al 2008].

Clinical findings

• Bilateral congenital cataracts. One individual had juvenile cataract [Ugur & Tolun 2008]; one individual had only a mild lens opacity, noted at age three years [Biancheri et al 2011].
• Nystagmus present from the first few weeks of life
• Classic presentation shows normal or mildly delayed psychomotor development in the first year of life, followed by slowly progressive neurologic impairment manifest as:
  • Ataxia
  • Spasticity
  • Loss of the ability to walk
  • Mild-to-moderate cognitive impairment
• Uncommon presentations [Biancheri et al 2011]
  • Early-onset severe variant. Hypotonia and feeding difficulties in the neonatal period, developmental delay in the first months of life, and wheelchair dependency in early childhood
  • Late-onset mild variant. Normal development in the first two years of life with subsequent sudden motor regression

MRI findings

• Diffusely abnormal supratentorial white matter in all individuals
• Abnormal white matter signal behavior consistent with hypomyelination:
  • Hyperintense on T₂-weighted images (intermediate hyperintensity between that of myelinated white matter and CSF) (Figure 1)
  • Isointense to slightly hypointense on T₁-weighted images (Figure 2)
• Areas of higher T₂-weighted signal intensity with corresponding low-signal intensity on T₁-weighted images consistent with areas of increased white matter water content of variable extension in some individuals (Figure 3)
• White matter bulk loss in older individuals (Figure 4)
• Medullary centers of the cerebellar hemispheres showing mildly increased T₂-weighted signal intensity, paralleling that of the adjacent cortical gray matter and resulting in a "blurred" gray-white matter interface in some individuals (Figure 5)
• Sparing of the cortical and deep gray matter structures

Figure 1.

Axial T₂-weighted image shows diffuse hyperintensity of supratentorial white matter consistent with hypomyelination.

2. . Axial T1-weighted image shows diffusely isointense white matter with poor demarcation from adjacent gray matter, consistent with hypomyelination.">

Figure 2.

Axial T₁-weighted image shows diffusely isointense white matter with poor demarcation from adjacent gray matter, consistent with hypomyelination.

Figure 3.

Axial T₁-weighted image (panel A) and axial T₂-weighted image (panel B) show areas of increased water content involving the deep frontal white matter.

Figure 4.

Axial T₂-weighted image in a 15-year-old shows enlargement of ventricles and subarachnoid spaces consistent with cerebral atrophy. The periventricular white matter is more hyperintense than the subcortical white matter, suggesting superimposed gliosis. (more...)

Figure 5.

Coronal T₂-weighted image shows poor gray-white matter demarcation at the level of the medullary centers of the cerebellum, suggesting abnormal myelination of the cerebellar white matter.

Establishing the Diagnosis

The diagnosis of HCC is established in a proband with suggestive findings and biallelic pathogenic variants in FAM126A identified by molecular genetic testing (see Table 1).

Note: Identification of biallelic FAM126A variants of uncertain significance (or identification of one known FAM126A pathogenic variant and one FAM126A variant of uncertain significance) does not establish or rule out a diagnosis of this disorder.

Molecular testing approaches can include a combination of gene-targeted testing (single-gene testing or multigene panel) and comprehensive genomic testing (exome sequencing, genome sequencing) depending on the phenotype.

Gene-targeted testing requires that the clinician determine which gene(s) are likely involved, whereas genomic testing does not. Individuals with the distinctive findings described in Suggestive Findings are likely to be diagnosed using gene-targeted testing (see Option 1), whereas those with a phenotype indistinguishable from many other inherited disorders with cataracts and/or leukodystrophy are more likely to be diagnosed using genomic testing (see Option 2).

Clinical Description

Hypomyelination and congenital cataract (HCC) phenotype is quite consistent in the affected individuals described to date.

Prenatal/perinatal. All affected individuals have normal prenatal and perinatal histories.

Ophthalmologic. Bilateral congenital cataracts identified at birth or within the first month of life are the first clinical sign. All children underwent ocular surgery in the first months of life with the exception of the one child who had adolescent-onset cataracts [Ugur & Tolun 2008].

Psychomotor development is normal up until the end of the first year of life, when developmental delays appear [Biancheri et al 2007]. The ability to walk with support is achieved between ages 12 and 24 months. Independent walking is not achieved in all individuals. Slowly progressive neurologic impairment then becomes apparent with gradual loss of the ability to walk. Most individuals become wheelchair bound between ages eight and nine years [Biancheri et al 2007].

Feeding issues occur due to neurologic impairment. Swallowing may become difficult, and growth may be affected by suboptimal intake.

Cognitive skills. All individuals have mild-to-moderate intellectual disability without deterioration in cognitive ability over time.

Neurologic findings. Clinical examination reveals the following from the onset of the disease course:

• Dysarthria
• Truncal hypotonia
• Pyramidal signs and spasticity. Tendon reflexes may be decreased or lost due to peripheral neuropathy.
• Cerebellar signs/ataxia (including truncal titubation and intention tremor)
• Peripheral neuropathy, present in most individuals, manifest as muscle weakness, wasting of the legs and ataxia. Peripheral neuropathy is absent in individuals with a milder form of the disorder (see Genotype-Phenotype Correlations).

Seizures including those triggered by fever may occur, but are not a predominant clinical feature.

Neurophysiologic investigations show the following from the onset of the disease course:

• Motor nerve conduction velocity. Slightly to markedly slowed in most individuals, with lower values in older persons
• Compound muscle action potentials. Reduced amplitude
• Electromyography. Signs of denervation in the absence of spontaneous activity
• Waking EEG. Irregular background activity; multifocal epileptiform discharges may be recorded.
• Brain stem auditory evoked potentials. Increased I-V interpeak conduction time in individuals older than age two years
• Electroretinogram. Normal

Neuropathologic findings

• Sural nerve biopsy of individuals with peripheral neuropathy shows a slight-to-severe reduction in density of myelinated fibers, with several axons surrounded by a thin myelin sheath or devoid of myelin.
• Uncompaction of the myelin sheath, which in some fibers appears redundant and irregularly folded, is occasionally seen.
• Electron microscopy confirms the presence of axons devoid of myelin, together with thinly myelinated fibers, sometimes surrounded by few Schwann cells processes, forming small onion bulbs.

Orthopedic issues. A slowly progressive scoliosis appears concurrently with the loss of the ability to walk [Biancheri et al 2007].

Life expectancy is unknown; the oldest living affected individual is age 34 years.

Genotype-Phenotype Correlations

Pathogenic variants leading to the complete absence of FAM126A protein expression are associated with the full phenotype of bilateral cataract, central nervous system hypomyelination, and peripheral nerve hypomyelination.

Pathogenic variants leading to a partial protein deficiency are associated with the milder form without peripheral nervous system involvement.

An individual with deletion of exons 8 and 9 did not have congenital cataracts; cataracts developed at age nine years. A second individual had congenital unilateral cataract. However, of the four children in this family who survived beyond age two years, none was able to walk even with support after age six years [Ugur & Tolun 2008].

Because of the limited number of individuals with HCC described so far, these correlations should be further confirmed.

Penetrance

Penetrance is complete.

Prevalence

HCC is likely a rare disorder. No epidemiologic studies are available.

Evaluations Following Initial Diagnosis

To establish the extent of disease and needs in an individual diagnosed with hypomyelination and congenital cataract (HCC), the evaluations summarized in Table 4 (if not performed as part of the evaluation that led to the diagnosis) are recommended.

Treatment of Manifestations

Surveillance

Agents/Circumstances to Avoid

None are known. Some individuals are prone to febrile seizures.

Evaluation of Relatives at Risk

See Genetic Counseling for issues related to testing of at-risk relatives for genetic counseling purposes.

Therapies Under Investigation

Search ClinicalTrials.gov in the US and EU Clinical Trials Register in Europe for access to information on clinical studies for a wide range of diseases and conditions